$152+ Cheap flights from San Francisco to Greenville (SFO - GSP)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — GSP
Nov 21 — Nov 281
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from San Francisco to Greenville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Greenville
Cheapest
Best
Last-minute
One-way
Cheapest flights from San Francisco to GreenvilleExplore the most affordable flight options available from San Francisco to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2026.
Explore the most affordable flight options available from San Francisco to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2026.
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1512:10 pm -
1 stop7h 50m
Wed 11/1811:20 am -
1 stop7h 30m
Deal found 10/21![Southwest logo]()
$303
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/110:59 pm -
1 stop7h 41m
Tue 12/157:00 am -
1 stop8h 47m
Deal found 10/21![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:40 pm -
1 stop8h 31m
Sun 11/157:20 am -
1 stop10h 06m
Deal found 10/20![Delta logo]()
$384
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/110:59 pm -
1 stop7h 41m
Thu 12/35:40 am -
2 stops10h 44m
Deal found 10/20![Delta logo]()
$392
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:35 am -
1 stop7h 52m
Sun 11/153:58 pm -
1 stop10h 01m
Deal found 10/20![American Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:35 am -
1 stop7h 52m
Wed 11/186:29 am -
1 stop8h 54m
Deal found 10/21![American Airlines logo]()
$477
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2611:46 pm -
1 stop8h 27m
Thu 12/315:22 pm -
1 stop9h 02m
Deal found 10/19![American Airlines logo]()
$494
This American Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/111:52 am -
1 stop10h 03m
Thu 12/35:17 pm -
1 stop8h 14m
Deal found 10/17![American Airlines logo]()
$497
Best flights from San Francisco to GreenvilleDiscover carefully curated flight deals from San Francisco to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 22, 2026.
Discover carefully curated flight deals from San Francisco to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 22, 2026.
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/110:59 pm -
1 stop7h 41m
Tue 12/157:00 am -
1 stop8h 47m
Deal found 10/21![Delta logo]()
$317
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/119:25 pm -
1 stop9h 45m
Sun 11/156:40 am -
2 stops9h 25m
Deal found 10/19![Southwest logo]()
$589
This Alaska Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:29 pm -
2 stops20h 46m
Tue 12/151:55 pm -
2 stops22h 05m
Deal found 10/18![Alaska Airlines logo]()
$679
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 am -
1 stop9h 09m
Wed 11/185:40 am -
2 stops10h 35m
Deal found 10/21![Delta logo]()
$598
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1212:10 pm -
1 stop7h 50m
Sun 11/156:40 am -
2 stops10h 45m
Deal found 10/20![Southwest logo]()
$608
This Southwest deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/112:10 pm -
1 stop7h 45m
Thu 11/56:40 am -
2 stops10h 45m
Deal found 10/17![Southwest logo]()
$642
This Alaska Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/15:44 pm -
2 stops14h 28m
Tue 1/511:43 am -
2 stops14h 13m
Deal found 10/17![Alaska Airlines logo]()
$728
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/69:40 am -
2 stops10h 20m
Sat 11/77:05 am -
2 stops10h 25m
Deal found 10/21![Southwest logo]()
$647
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2111:59 pm -
1 stop8h 08m
Mon 11/307:19 pm -
1 stop7h 39m
Deal found 10/19![Delta logo]()
$719
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/229:25 pm -
1 stop9h 45m
Fri 11/276:40 am -
2 stops11h 50m
Deal found 10/20![Southwest logo]()
$729
Last-minute flights from San Francisco to GreenvilleDiscover last-minute flight deals from San Francisco to Greenville. Data last updated October 22, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Greenville. Data last updated October 22, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:35 am -
1 stop7h 52m
Wed 11/186:29 am -
1 stop8h 54m
Deal found 10/21![American Airlines logo]()
$477
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/610:25 pm -
1 stop8h 36m
Wed 11/115:40 am -
2 stops10h 35m
Deal found 10/22![Delta logo]()
$551
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:35 am -
1 stop7h 52m
Sun 11/153:58 pm -
1 stop10h 01m
Deal found 10/20![American Airlines logo]()
$409
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/119:25 pm -
1 stop9h 45m
Sun 11/156:40 am -
2 stops9h 25m
Deal found 10/19![Southwest logo]()
$589
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:40 pm -
1 stop8h 31m
Sun 11/157:20 am -
1 stop10h 06m
Deal found 10/20![Delta logo]()
$384
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1312:10 pm -
1 stop7h 50m
Sun 11/156:40 am -
2 stops9h 25m
Deal found 10/18![Southwest logo]()
$537
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/131:22 pm -
1 stop7h 05m
Sun 11/153:58 pm -
1 stop10h 01m
Deal found 10/18![American Airlines logo]()
$569
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1512:10 pm -
1 stop7h 50m
Wed 11/1811:20 am -
1 stop7h 30m
Deal found 10/21![Southwest logo]()
$303
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:45 pm -
2 stops11h 25m
Fri 11/276:40 am -
2 stops11h 50m
Deal found 10/21![Southwest logo]()
$577
One-way flights from San Francisco to GreenvilleSearch for one-way flight options from San Francisco to Greenville. Find affordable one-way fares based on user searches. Data last updated October 22, 2026.
Search for one-way flight options from San Francisco to Greenville. Find affordable one-way fares based on user searches. Data last updated October 22, 2026.
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/169:25 pm -
1 stop10h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Southwest logo]()
$152
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1110:40 am -
2 stops9h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Southwest logo]()
$157
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1410:59 pm -
1 stop9h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Delta logo]()
$159
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:20 am -
2 stops8h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Southwest logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:02 am -
2 stops10h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/149:16 pm -
3 stops55h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$192
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/136:30 am -
2 stops34h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Multiple Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/410:17 pm -
2 stops30h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$210
Find flight deals from San Francisco to Greenville
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $303 (Southwest) |
One-way from | $152 (Southwest) |
Popular in | May |
Cheapest in | January |
Average price | $547 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 22, 2026.
Use the filters below to find and compare flights from San Francisco to Greenville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San FranciscoGreenville
SFO San Francisco - GSP Greenville
SFOGSP
San Francisco
Sun 12/13
9:25 pm-10:45 am
1 stop10h 20m
Greenville
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$152
San FranciscoGreenville
SFO San Francisco - GSP Greenville
SFOGSP
San Francisco
Mon 11/16
9:25 pm-10:45 am
1 stop10h 20m
Greenville
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$152
Quickest round-trip
San FranciscoGreenville
SFO San Francisco - GSP Greenville
SFOGSP
San Francisco
Mon 12/14
10:59 pm-11:13 am
1 stop9h 14m
Greenville
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$159
San FranciscoGreenville
SFO San Francisco - GSP Greenville
SFOGSP
San Francisco
Tue 10/27
7:14 pm-7:59 pm
3 stops45h 45m
Greenville
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$214
San FranciscoGreenville
SFO San Francisco - GSP Greenville
SFOGSP
San Francisco
Sun 12/6
9:05 am-11:00 pm
2 stops10h 55m
Greenville
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$232
San FranciscoGreenville
SFO San Francisco - GSP Greenville
SFOGSP
San Francisco
Tue 11/3
10:17 pm-7:53 am
3 stops30h 36m
Greenville
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$243
San FranciscoGreenville
SFO San Francisco - GSP Greenville
SFOGSP
San Francisco
Thu 12/24
9:25 pm-10:45 am
1 stop10h 20m
Greenville
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$249
San FranciscoGreenville
SFO San Francisco - GSP Greenville
SFOGSP
San Francisco
Tue 12/1
10:59 pm-9:40 am
1 stop7h 41m
Greenville
Tue 12/15
7:00 am-12:47 pm
1 stop8h 47m
$317
San FranciscoGreenville
SFO San Francisco - GSP Greenville
SFOGSP
San Francisco
Wed 11/11
9:25 pm-10:10 am
1 stop9h 45m
Greenville
Sun 11/15
6:40 am-1:05 pm
2 stops9h 25m
$589
San FranciscoGreenville
SFO San Francisco - GSP Greenville
SFOGSP
San Francisco
Wed 11/4
6:00 am-6:09 pm
1 stop9h 09m
Greenville
Wed 11/18
5:40 am-1:15 pm
2 stops10h 35m
$598
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Greenville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Greenville in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Francisco-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Greenville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Greenville
Have a flexible travel schedule? Discover the best time to fly to Greenville from San Francisco with our price prediction graph.
SFO-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Greenville
What is the cheapest month to book a flight from San Francisco to Greenville?
Currently, January is the cheapest month in which you can book a flight from San Francisco to Greenville (average of $393). Flying from San Francisco to Greenville in May is currently the most expensive (average of $698). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Francisco to Greenville?
Airfare is below average for this route at the moment.
San Francisco to Greenville flights typically cost between $510 and $713 in November.The cheapest round-trip price found within the last 5 days was $303 on Southwest (Nov 15-Nov 18).
Reviews of airlines servicing Greenville
Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated October 22, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from San Francisco to Greenville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Comfort
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Comfort
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Comfort
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentMichael,Sep 2023
SMF - ATL
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Greenville?
Book flights to Greenville if you plan to visit one of these locationsGreer
Simpsonville
Greenwood
Duncan
Anderson
Seneca
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Greenville flight routes
Other flight options
Other flights from San Francisco
Popular flights
Alternative routes for San Francisco to Greenville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Greenville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from San Francisco to Greenville by cabin class
Find flights from San Francisco to Greenville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Greenville
Explore flights to Greenville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 22, 2026.
San Francisco and Greenville flights
Browse other San Francisco and Greenville flight options. Last updated on October 22, 2026.
Other flights from San Francisco
Browse through other flights departing from San Francisco. Flights are based on user searches made on Cheapflights and were last updated on October 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from San Francisco to Greenville
Discover the top 3 airlines that operate flights from San Francisco to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$336 | Average$566 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$339 | Average$546 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$424 | Average$511 | FlexibilityNo cancel fee | On-time69% |