$159+ Cheap flights from Myrtle Beach to San Diego (MYR - SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SAN
Nov 24 — Dec 11
Round-trip
1 adult, Economy
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Find cheap flights from Myrtle Beach to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Myrtle Beach to San Diego
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Cheapest flights from Myrtle Beach to San DiegoExplore the most affordable flight options available from Myrtle Beach to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from Myrtle Beach to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1312:47 pm -
1 stop9h 17m
Sat 11/219:45 pm -
1 stop9h 35m
Deal found 10/20![American Airlines logo]()
$419
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:27 am -
1 stop10h 42m
Wed 11/119:40 pm -
1 stop9h 41m
Deal found 10/20![United Airlines logo]()
$447
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/257:25 am -
2 stops11h 08m
Thu 12/319:35 am -
2 stops10h 20m
Deal found 10/20![American Airlines logo]()
$461
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/511:27 am -
1 stop9h 28m
Thu 11/1210:10 pm -
1 stop9h 30m
Deal found 10/21![Delta logo]()
$477
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:27 am -
2 stops14h 00m
Wed 11/189:40 pm -
1 stop9h 41m
Deal found 10/21![United Airlines logo]()
$482
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/141:52 pm -
1 stop9h 54m
Thu 11/199:30 am -
2 stops9h 33m
Deal found 10/20![American Airlines logo]()
$496
Best flights from Myrtle Beach to San DiegoDiscover carefully curated flight deals from Myrtle Beach to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from Myrtle Beach to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/136:00 am -
1 stop10h 08m
Tue 1/1910:40 pm -
1 stop8h 28m
Deal found 10/23![Delta logo]()
$317
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/138:07 am -
2 stops10h 27m
Tue 1/196:15 am -
1 stop7h 05m
Deal found 10/23![American Airlines logo]()
$362
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:27 am -
1 stop10h 42m
Wed 11/119:40 pm -
1 stop9h 41m
Deal found 10/23![United Airlines logo]()
$447
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/411:27 am -
2 stops14h 13m
Mon 11/910:20 pm -
1 stop9h 01m
Deal found 10/19![United Airlines logo]()
$482
Last-minute flights from Myrtle Beach to San DiegoDiscover last-minute flight deals from Myrtle Beach to San Diego. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from Myrtle Beach to San Diego. Data last updated October 25, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/511:27 am -
1 stop9h 28m
Thu 11/1210:10 pm -
1 stop9h 30m
Deal found 10/21![Delta logo]()
$477
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:27 am -
2 stops14h 00m
Wed 11/189:40 pm -
1 stop9h 41m
Deal found 10/21![United Airlines logo]()
$482
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:27 am -
1 stop10h 42m
Wed 11/119:40 pm -
1 stop9h 41m
Deal found 10/20![United Airlines logo]()
$447
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1312:47 pm -
1 stop9h 17m
Sat 11/219:45 pm -
1 stop9h 35m
Deal found 10/20![American Airlines logo]()
$419
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1311:27 am -
2 stops14h 03m
Sat 11/2110:20 pm -
1 stop9h 01m
Deal found 10/20![United Airlines logo]()
$497
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/141:52 pm -
1 stop9h 54m
Thu 11/199:30 am -
2 stops9h 33m
Deal found 10/20![American Airlines logo]()
$496
One-way flights from Myrtle Beach to San DiegoSearch for one-way flight options from Myrtle Beach to San Diego. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from Myrtle Beach to San Diego. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/161:54 pm -
1 stop9h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![American Airlines logo]()
$159
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2610:52 am -
1 stop8h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Delta logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/302:41 pm -
3 stops46h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$235
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:27 am -
2 stops13h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![United Airlines logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:25 pm -
2 stops24h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:33 pm -
3 stops35h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Multiple Airlines logo]()
$248
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:59 pm -
1 stop7h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Delta logo]()
$249
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:50 am -
2 stops10h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Southwest logo]()
$254
Find flight deals from Myrtle Beach to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $317 (Delta) |
One-way from | $159 (American Airlines) |
Popular in | October |
Cheapest in | February |
Average price | $719 |
Cheapflights Fare Finder
Customize your flight search to find flights from Myrtle Beach to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from Myrtle Beach to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Myrtle BeachSan Diego
MYR Myrtle Beach Intl - SAN San Diego
MYRSAN
Myrtle Beach Intl
Wed 12/16
1:54 pm-8:48 pm
1 stop9h 54m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$159
Quickest round-trip
Myrtle BeachSan Diego
MYR Myrtle Beach Intl - SAN San Diego
MYRSAN
Myrtle Beach Intl
Thu 12/17
6:59 pm-11:38 pm
1 stop7h 39m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$193
Myrtle BeachSan Diego
MYR Myrtle Beach Intl - SAN San Diego
MYRSAN
Myrtle Beach Intl
Thu 11/26
10:52 am-4:33 pm
1 stop8h 41m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$204
Myrtle BeachSan Diego
MYR Myrtle Beach Intl - SAN San Diego
MYRSAN
Myrtle Beach Intl
Wed 1/13
6:00 am-1:08 pm
1 stop10h 08m
San Diego
Tue 1/19
10:40 pm-10:08 am
1 stop8h 28m
$317
Myrtle BeachSan Diego
MYR Myrtle Beach Intl - SAN San Diego
MYRSAN
Myrtle Beach Intl
Wed 1/13
8:07 am-3:34 pm
2 stops10h 27m
San Diego
Tue 1/19
6:15 am-4:20 pm
1 stop7h 05m
$362
Myrtle BeachSan Diego
MYR Myrtle Beach Intl - SAN San Diego
MYRSAN
Myrtle Beach Intl
Tue 11/10
11:27 am-7:09 pm
1 stop10h 42m
San Diego
Wed 11/11
9:40 pm-10:21 am
1 stop9h 41m
$447
Myrtle BeachSan Diego
MYR Myrtle Beach Intl - SAN San Diego
MYRSAN
Myrtle Beach Intl
Wed 11/4
11:27 am-10:40 pm
2 stops14h 13m
San Diego
Mon 11/9
10:20 pm-10:21 am
1 stop9h 01m
$482
Sorted by cheapest first
Compare providers for flights from Myrtle Beach to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to San Diego in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Myrtle Beach-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Myrtle Beach-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Myrtle Beach to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Myrtle Beach with our price prediction graph.
MYR-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Myrtle Beach to San Diego
What is the cheapest month to book a flight from Myrtle Beach to San Diego?
Currently, February is the cheapest month in which you can book a flight from Myrtle Beach to San Diego (average of $395). Flying from Myrtle Beach to San Diego in October is currently the most expensive (average of $719). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Myrtle Beach to San Diego?
Airfare is below average for this route at the moment.
Myrtle Beach to San Diego flights typically cost between $517 and $712 in January.The cheapest round-trip price found within the last 5 days was $317 on Delta (Jan 13-Jan 19).
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated October 25, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Myrtle Beach to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Entertainment
7.4
Crew
8.6
Overall
7.9
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Entertainment
7.4
Crew
8.6
Overall
7.9
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Entertainment
7.4
Crew
8.6
Overall
7.9
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Entertainment
7.4
Crew
8.6
Overall
7.9
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Myrtle Beach to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
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Julian
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Lemon Grove
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Complete your trip
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Search flights from Myrtle Beach to San Diego by cabin class
Find flights from Myrtle Beach to San Diego, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Myrtle Beach and San Diego flights
Browse other Myrtle Beach and San Diego flight options. Last updated on October 25, 2026.
Other flights from Myrtle Beach
Browse through other flights departing from Myrtle Beach. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Top 3 airlines flying from Myrtle Beach to San Diego
Discover the top 3 airlines that operate flights from Myrtle Beach to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$298 | Average$466 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$327 | Average$527 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$456 | Average$516 | FlexibilityNo cancel fee | On-time63% |