$182+ Cheap flights from Myrtle Beach to San Diego (MYR - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/10. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SAN
Aug 22 — Aug 291
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Myrtle Beach to San Diego
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Cheapest flights from Myrtle Beach to San DiegoExplore the most affordable flight options available from Myrtle Beach to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.
Explore the most affordable flight options available from Myrtle Beach to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:01 pm
MYR
- SAN
1 stop7h 47m
American Airlines
Mon 9/2810:27 pm
SAN
- MYR
1 stop8h 19m
American Airlines
Deal found 7/22![American Airlines logo]()
$363
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:23 am
MYR
- SAN
2 stops14h 47m
United Airlines
Wed 8/269:45 pm
SAN
- MYR
1 stop8h 59m
United Airlines
Deal found 7/22![United Airlines logo]()
$368
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:15 pm
MYR
- SAN
2 stops9h 44m
American Airlines
Mon 8/176:45 am
SAN
- MYR
1 stop6h 40m
American Airlines
Deal found 7/22![American Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/118:08 am
MYR
- SAN
1 stop7h 40m
American Airlines
Sat 8/2210:45 pm
SAN
- MYR
1 stop9h 49m
American Airlines
Deal found 7/19![American Airlines logo]()
$414
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/273:20 pm
MYR
- SAN
1 stop10h 25m
Southwest
Sun 8/3010:40 pm
SAN
- MYR
1 stop8h 35m
Southwest
Deal found 7/20![Southwest logo]()
$415
This Southwest deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:55 am
MYR
- SAN
2 stops10h 15m
Southwest
Fri 9/116:45 am
SAN
- MYR
1 stop7h 50m
Southwest
Deal found 7/18![Southwest logo]()
$416
This Southwest deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:50 am
MYR
- SAN
1 stop7h 25m
Southwest
Mon 9/219:00 pm
SAN
- MYR
2 stops10h 05m
Southwest
Deal found 7/18![Southwest logo]()
$418
Best flights from Myrtle Beach to San DiegoDiscover carefully curated flight deals from Myrtle Beach to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 23, 2026.
Discover carefully curated flight deals from Myrtle Beach to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 23, 2026.
This Delta deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:34 am
MYR
- SAN
1 stop10h 01m
Delta
Mon 9/2810:20 pm
SAN
- MYR
1 stop9h 16m
Delta
Deal found 7/18![Delta logo]()
$413
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:10 am
MYR
- SAN
1 stop7h 15m
Southwest
Sun 8/3010:40 pm
SAN
- MYR
1 stop8h 35m
Southwest
Deal found 7/19![Southwest logo]()
$440
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:23 am
MYR
- SAN
1 stop7h 34m
United Airlines
Sat 8/299:45 pm
SAN
- MYR
1 stop8h 59m
United Airlines
Deal found 7/22![United Airlines logo]()
$473
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/811:25 am
MYR
- SAN
2 stops11h 24m
United Airlines
Tue 12/1510:30 pm
SAN
- MYR
1 stop9h 07m
United Airlines
Deal found 7/21![United Airlines logo]()
$478
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/136:50 pm
MYR
- SAN
1 stop7h 15m
Southwest
Sun 9/208:55 pm
SAN
- MYR
2 stops10h 20m
Southwest
Deal found 7/19![Southwest logo]()
$482
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/47:02 pm
MYR
- SAN
1 stop6h 58m
Delta
Thu 8/1312:32 pm
SAN
- MYR
1 stop7h 58m
Delta
Deal found 7/20![Delta logo]()
$500
This Southwest deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2410:35 am
MYR
- SAN
1 stop13h 35m
Southwest
Tue 12/16:30 am
SAN
- MYR
2 stops9h 55m
Southwest
Deal found 7/18![Southwest logo]()
$488
This Southwest deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:10 pm
MYR
- SAN
1 stop7h 45m
Southwest
Sat 11/286:35 am
SAN
- MYR
1 stop9h 55m
Southwest
Deal found 7/18![Southwest logo]()
$492
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:10 pm
MYR
- SAN
1 stop7h 45m
Southwest
Sun 11/2910:35 pm
SAN
- MYR
1 stop12h 45m
Southwest
Deal found 7/20![Southwest logo]()
$528
Last-minute flights from Myrtle Beach to San DiegoDiscover last-minute flight deals from Myrtle Beach to San Diego. Data last updated July 23, 2026 and is based on user searches.
Discover last-minute flight deals from Myrtle Beach to San Diego. Data last updated July 23, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/118:08 am
MYR
- SAN
1 stop7h 40m
American Airlines
Sat 8/2210:45 pm
SAN
- MYR
1 stop9h 49m
American Airlines
Deal found 7/19![American Airlines logo]()
$414
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/134:23 pm
MYR
- SAN
1 stop9h 07m
American Airlines
Mon 8/176:45 am
SAN
- MYR
1 stop6h 40m
American Airlines
Deal found 7/22![American Airlines logo]()
$363
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:23 am
MYR
- SAN
2 stops14h 47m
United Airlines
Wed 8/269:45 pm
SAN
- MYR
1 stop8h 59m
United Airlines
Deal found 7/22![United Airlines logo]()
$368
This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/273:20 pm
MYR
- SAN
1 stop10h 25m
Southwest
Sun 8/3010:40 pm
SAN
- MYR
1 stop8h 35m
Southwest
Deal found 7/20![Southwest logo]()
$415
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/274:23 pm
MYR
- SAN
1 stop9h 07m
American Airlines
Sun 8/309:43 am
SAN
- MYR
2 stops9h 09m
American Airlines
Deal found 7/22![American Airlines logo]()
$423
This United Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:23 am
MYR
- SAN
2 stops11h 07m
United Airlines
Sun 8/309:45 pm
SAN
- MYR
1 stop8h 59m
United Airlines
Deal found 7/21![United Airlines logo]()
$425
One-way flights from Myrtle Beach to San DiegoSearch for one-way flight options from Myrtle Beach to San Diego. Find affordable one-way fares based on user searches. Data last updated July 23, 2026.
Search for one-way flight options from Myrtle Beach to San Diego. Find affordable one-way fares based on user searches. Data last updated July 23, 2026.
This American Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:01 pm
MYR
- SAN
1 stop9h 54m
American Airlines
Deal found 7/19![American Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:41 pm
MYR
- SAN
3 stops39h 24m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$183
This Delta deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:56 pm
MYR
- SAN
1 stop6h 58m
Delta
Deal found 7/22![Delta logo]()
$187
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/141:48 pm
MYR
- SAN
3 stops37h 11m
Multiple Airlines
Deal found 7/19![Multiple Airlines logo]()
$188
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/13:53 pm
MYR
- SAN
3 stops34h 58m
Multiple Airlines
Deal found 7/19![Multiple Airlines logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:41 pm
MYR
- SAN
3 stops39h 24m
Multiple Airlines
Deal found 7/18![Multiple Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/309:07 pm
MYR
- SAN
3 stops38h 58m
Multiple Airlines
Deal found 7/19![Multiple Airlines logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/281:13 pm
MYR
- SAN
2 stops49h 11m
Multiple Airlines
Deal found 7/19![Multiple Airlines logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:30 pm
MYR
- SAN
2 stops30h 21m
Frontier
Deal found 7/19![Frontier logo]()
$204
Find flight deals from Myrtle Beach to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $363 (American Airlines) |
One-way from | $179 (Kiwi.com) |
Popular in | December |
Cheapest in | September |
Average price | $502 |
Cheapflights Fare Finder
Customize your flight search to find flights from Myrtle Beach to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
Use the filters below to find and compare flights from Myrtle Beach to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Myrtle BeachSan Diego
MYR - SAN
MYRSAN
Myrtle Beach Intl
Wed 9/23
11:34 am-6:35 pm
1 stop10h 01m
San Diego
Mon 9/28
10:20 pm-10:36 am
1 stop9h 16m
$413
Myrtle BeachSan Diego
MYR - SAN
MYRSAN
Myrtle Beach Intl
Thu 8/27
8:10 am-12:25 pm
1 stop7h 15m
San Diego
Sun 8/30
10:40 pm-10:15 am
1 stop8h 35m
$440
Myrtle BeachSan Diego
MYR - SAN
MYRSAN
Myrtle Beach Intl
Wed 8/26
10:23 am-2:57 pm
1 stop7h 34m
San Diego
Sat 8/29
9:45 pm-9:44 am
1 stop8h 59m
$473
Myrtle BeachSan Diego
MYR - SAN
MYRSAN
Myrtle Beach Intl
Tue 12/8
11:25 am-7:49 pm
2 stops11h 24m
San Diego
Tue 12/15
10:30 pm-10:37 am
1 stop9h 07m
$478
Myrtle BeachSan Diego
MYR - SAN
MYRSAN
Myrtle Beach Intl
Sun 9/13
6:50 pm-11:05 pm
1 stop7h 15m
San Diego
Sun 9/20
8:55 pm-10:15 am
2 stops10h 20m
$482
Myrtle BeachSan Diego
MYR - SAN
MYRSAN
Myrtle Beach Intl
Tue 11/24
10:35 am-9:10 pm
1 stop13h 35m
San Diego
Tue 12/1
6:30 am-7:25 pm
2 stops9h 55m
$488
Myrtle BeachSan Diego
MYR - SAN
MYRSAN
Myrtle Beach Intl
Sat 11/21
7:10 pm-11:55 pm
1 stop7h 45m
San Diego
Sat 11/28
6:35 am-7:30 pm
1 stop9h 55m
$492
Quickest round-trip
Myrtle BeachSan Diego
MYR - SAN
MYRSAN
Myrtle Beach Intl
Tue 8/4
7:02 pm-11:00 pm
1 stop6h 58m
San Diego
Thu 8/13
12:32 pm-11:30 pm
1 stop7h 58m
$500
Myrtle BeachSan Diego
MYR - SAN
MYRSAN
Myrtle Beach Intl
Sat 11/21
7:10 pm-11:55 pm
1 stop7h 45m
San Diego
Sun 11/29
10:35 pm-2:20 pm
1 stop12h 45m
$528
Cheapest one-way
Quickest one-way
Myrtle BeachSan Diego
MYR - SAN
MYRSAN
Myrtle Beach Intl
Mon 9/14
6:56 pm-10:54 pm
1 stop6h 58m
$182
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Myrtle Beach to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to San Diego in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Myrtle Beach-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Myrtle Beach-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Myrtle Beach to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Myrtle Beach with our price prediction graph.
MYR-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Myrtle Beach to San Diego
What is the cheapest month to book a flight from Myrtle Beach to San Diego?
Currently, September is the cheapest month in which you can book a flight from Myrtle Beach to San Diego (average of $365). Flying from Myrtle Beach to San Diego in December is currently the most expensive (average of $642). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Myrtle Beach to San Diego?
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated July 23, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Myrtle Beach to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Myrtle Beach to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
Poway
La Mesa
Coronado
Santee
San Ysidro
Julian
Lemon Grove
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Myrtle Beach and San Diego flights
Browse other Myrtle Beach and San Diego flight options. Last updated on July 23, 2026.
Other flights from Myrtle Beach
Browse through other flights departing from Myrtle Beach. Flights are based on user searches made on Cheapflights and were last updated on July 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 23, 2026.
Top 3 airlines flying from Myrtle Beach to San Diego
Discover the top 3 airlines that operate flights from Myrtle Beach to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$296 | Average$495 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$298 | Average$492 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$456 | Average$522 | FlexibilityNo cancel fee | On-time63% |