How long is the flight from South Carolina to Panama City?

A quick flight from South Carolina to Panama City can take about 7h 17m. American Airlines provides one of the quickest options available for as low as $391. There are 1792 mi between South Carolina and Panama City. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines to fly from South Carolina to Panama City one-way?

The cheapest airlines for a one-way flight from South Carolina to Panama City are United Airlines ($169), American Airlines ($169), and Delta ($205).

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the most popular routes from South Carolina to Panama City?

The most popular route from South Carolina to Panama City is Charlotte Douglas - Panama City Tocumen Intl. You may also consider Charleston - Panama City Tocumen Intl or Columbia Metropolitan - Panama City Tocumen Intl.

What are the most popular airlines that fly from South Carolina to Panama City?

American Airlines, Delta and United Airlines are the most popular airlines when flying from South Carolina to Panama City.

What airport do you fly into for flights to Panama City from South Carolina?

Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Panama City from South Carolina.

Can I find deals for flights from South Carolina to Panama City that include hotel bookings?

Yes. In addition to deals on South Carolina to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from South Carolina to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama City.

Can I find deals for business class flights from South Carolina to Panama City?

Yes. Cheapflights offers flight deals from South Carolina to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$167+ Cheap Flights from South Carolina to Panama City

Q: How much does it cost to fly round-trip from South Carolina to Panama City?

Airfare is below average for this route at the moment. South Carolina to Panama City flights typically cost between $456 and $475 in January. The cheapest round-trip price found within the last 3 days was $374 on American Airlines (Jan 8-Jan 30).

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Cheap flight deals from South Carolina to Panama City

Round-trip from	$374 (American Airlines)
One-way from	$167 (Kiwi.com)

From South Carolina to Panama City Tocumen Intl

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One-way flight from South Carolina to Panama City Tocumen Intl

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Find flight deals from South Carolina to Panama City

Cheapest flights from South Carolina to Panama City
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

Mon 9/17:00 amCLT - PTY

2 stops18h 45mMultiple Airlines

Sun 9/75:25 pmPTY - CLT

2 stops18h 20mMultiple Airlines

Deal found 8/16

$391

Mon 10/207:54 pmCHS - PTY

2 stops19h 09mAmerican Airlines

Mon 10/273:15 pmPTY - CHS

2 stops19h 20mAmerican Airlines

Deal found 8/17

$394

Thu 10/27:44 pmGSP - PTY

2 stops19h 47mAmerican Airlines

Thu 10/93:15 pmPTY - GSP

1 stop7h 06mAmerican Airlines

Deal found 8/18

$396

Wed 10/15:45 amCLT - PTY

2 stops16h 25mMultiple Airlines

Wed 10/85:25 pmPTY - CLT

2 stops18h 14mMultiple Airlines

Deal found 8/16

$397

Wed 9/176:00 amCHS - PTY

1 stop8h 50mUnited Airlines

Sat 9/203:30 pmPTY - CHS

1 stop24h 05mUnited Airlines

Deal found 8/17

$398

Wed 9/1010:46 amCLT - PTY

2 stops14h 59mMultiple Airlines

Sun 9/145:25 pmPTY - CLT

2 stops18h 20mMultiple Airlines

Deal found 8/17

$398

Wed 9/176:16 pmCHS - PTY

2 stops21h 15mAmerican Airlines

Sun 9/213:31 pmPTY - CHS

2 stops26h 11mAmerican Airlines

Deal found 8/17

$399

Thu 10/166:15 amCLT - PTY

2 stops15h 55mMultiple Airlines

Sat 10/252:55 amPTY - CLT

2 stops17h 05mMultiple Airlines

Deal found 8/17

$407

Sun 10/199:42 amCHS - PTY

1 stop5h 21mAmerican Airlines

Mon 10/273:15 pmPTY - CHS

1 stop16h 46mAmerican Airlines

Deal found 8/17

$409

Mon 8/186:00 amGSP - PTY

1 stop8h 50mUnited Airlines

Mon 8/253:30 pmPTY - GSP

1 stop23h 16mUnited Airlines

Deal found 8/17

$412

Mon 9/157:44 pmGSP - PTY

2 stops18h 11mAmerican Airlines

Sun 9/213:31 pmPTY - GSP

2 stops25h 59mAmerican Airlines

Deal found 8/16

$419

Fri 10/1010:37 amCHS - PTY

1 stop28h 26mAmerican Airlines

Mon 10/133:15 pmPTY - CHS

2 stops17h 16mAmerican Airlines

Deal found 8/17

$422

Best flights from South Carolina to Panama City
Discover carefully curated flight deals from South Carolina to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 18, 2025.

Thu 1/87:46 pmCHS - PTY

2 stops17h 24mAmerican Airlines

Fri 1/302:45 pmPTY - CHS

1 stop8h 27mAmerican Airlines

Deal found 8/17

$374

Wed 1/216:45 amGSP - PTY

1 stop7h 17mDelta

Wed 2/43:27 pmPTY - GSP

1 stop8h 09mDelta

Deal found 8/16

$391

Mon 9/17:00 amCLT - PTY

2 stops18h 45mMultiple Airlines

Sun 9/75:25 pmPTY - CLT

2 stops18h 20mMultiple Airlines

Deal found 8/16

$391

Mon 12/14:59 pmCHS - PTY

2 stops20h 37mAmerican Airlines

Sat 12/132:45 pmPTY - CHS

2 stops17h 46mAmerican Airlines

Deal found 8/17

$394

Wed 10/15:45 amCLT - PTY

2 stops16h 25mMultiple Airlines

Wed 10/85:25 pmPTY - CLT

2 stops18h 14mMultiple Airlines

Deal found 8/16

$397

Wed 9/175:37 pmCHS - PTY

2 stops21h 54mAmerican Airlines

Sat 9/203:31 pmPTY - CHS

2 stops18h 48mAmerican Airlines

Deal found 8/17

$394

Thu 10/166:15 amCLT - PTY

2 stops15h 55mMultiple Airlines

Sun 10/265:55 pmPTY - CLT

2 stops17h 44mMultiple Airlines

Deal found 8/17

$397

Wed 10/15:30 amGSP - PTY

1 stop8h 25mDelta

Wed 10/82:21 pmPTY - GSP

1 stop8h 33mDelta

Deal found 8/16

$454

Mon 10/207:54 pmCHS - PTY

2 stops19h 09mAmerican Airlines

Mon 10/273:15 pmPTY - CHS

2 stops19h 20mAmerican Airlines

Deal found 8/17

$394

Wed 9/1010:46 amCLT - PTY

2 stops14h 59mMultiple Airlines

Sun 9/145:25 pmPTY - CLT

2 stops18h 20mMultiple Airlines

Deal found 8/17

$398

Tue 11/46:40 amSAV - PTY

1 stop7h 16mDelta

Tue 11/183:17 pmPTY - SAV

1 stop8h 42mDelta

Deal found 8/18

$467

Wed 1/216:24 pmGSP - PTY

2 stops21h 11mAmerican Airlines

Wed 2/44:40 pmPTY - GSP

2 stops17h 53mAmerican Airlines

Deal found 8/16

$396

Last-minute flights from South Carolina to Panama City
Discover last-minute flight deals from South Carolina to Panama City. Data last updated August 18, 2025 and is based on user searches.

Mon 8/186:00 amGSP - PTY

1 stop8h 50mUnited Airlines

Mon 8/253:30 pmPTY - GSP

1 stop23h 16mUnited Airlines

Deal found 8/17

$412

Fri 8/225:38 amCHS - PTY

1 stop9h 52mAmerican Airlines

Fri 8/293:30 pmPTY - CHS

2 stops26h 35mAmerican Airlines

Deal found 8/17

$438

Mon 9/17:00 amCLT - PTY

2 stops18h 45mMultiple Airlines

Sun 9/75:25 pmPTY - CLT

2 stops18h 20mMultiple Airlines

Deal found 8/16

$391

Mon 9/16:05 pmGSP - PTY

1 stop21h 25mAmerican Airlines

Sun 9/73:31 pmPTY - GSP

2 stops19h 15mAmerican Airlines

Deal found 8/16

$442

Wed 9/1010:46 amCLT - PTY

2 stops14h 59mMultiple Airlines

Sun 9/145:25 pmPTY - CLT

2 stops18h 20mMultiple Airlines

Deal found 8/17

$398

Wed 9/105:37 pmCHS - PTY

2 stops21h 54mAmerican Airlines

Sun 9/143:31 pmPTY - CHS

2 stops24h 14mAmerican Airlines

Deal found 8/16

$431

Wed 9/105:16 pmCHS - PTY

1 stop21h 58mUnited Airlines

Sun 9/143:30 pmPTY - CHS

1 stop24h 05mUnited Airlines

Deal found 8/17

$439

Mon 9/157:44 pmGSP - PTY

2 stops18h 11mAmerican Airlines

Sun 9/213:31 pmPTY - GSP

2 stops25h 59mAmerican Airlines

Deal found 8/16

$419

Mon 9/1510:20 pmCLT - PTY

1 stop10h 51mMultiple Airlines

Sun 9/219:33 pmPTY - CLT

1 stop9h 38mMultiple Airlines

Deal found 8/16

$435

Wed 9/175:37 pmCHS - PTY

2 stops21h 54mAmerican Airlines

Sat 9/203:31 pmPTY - CHS

2 stops18h 48mAmerican Airlines

Deal found 8/17

$394

Wed 9/176:00 amCHS - PTY

1 stop8h 50mUnited Airlines

Sat 9/203:30 pmPTY - CHS

1 stop24h 05mUnited Airlines

Deal found 8/17

$398

Wed 9/176:16 pmCHS - PTY

2 stops21h 15mAmerican Airlines

Sun 9/213:31 pmPTY - CHS

2 stops26h 11mAmerican Airlines

Deal found 8/17

$399

One-way flights from South Carolina to Panama City
Search for one-way flight options from South Carolina to Panama City. Find affordable one-way fares based on user searches. Data last updated August 18, 2025.

Sun 8/311:43 pmCLT - PTY

2 stops27h 47mMultiple Airlines

Deal found 8/18

$167

Thu 9/46:08 amGSP - PTY

1 stop8h 42mUnited Airlines

Deal found 8/16

$169

Fri 9/510:20 pmCLT - PTY

2 stops19h 10mMultiple Airlines

Deal found 8/18

$178

Thu 9/45:45 amCLT - PTY

2 stops16h 25mMultiple Airlines

Deal found 8/18

$179

Fri 9/191:50 pmCLT - PTY

2 stops11h 55mMultiple Airlines

Deal found 8/17

$181

Tue 9/27:00 amCLT - PTY

2 stops18h 10mMultiple Airlines

Deal found 8/18

$184

Sun 9/2110:20 pmCLT - PTY

3 stops15h 15mMultiple Airlines

Deal found 8/17

$188

Sat 9/201:50 pmCLT - PTY

2 stops23h 45mMultiple Airlines

Deal found 8/17

$190

Mon 10/135:45 amCAE - PTY

1 stop8h 11mDelta

Deal found 8/18

$205

Mon 9/11:49 pmCLT - PTY

3 stops23h 46mMultiple Airlines

Deal found 8/16

$207

Wed 9/39:10 amCLT - PTY

3 stops32h 20mMultiple Airlines

Deal found 8/16

$212

Mon 10/138:05 pmCAE - PTY

2 stops18h 58mAmerican Airlines

Deal found 8/18

$221

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 1/8

7:46 pm-1:10 pm

2 stops17h 24m

Panama City Tocumen Intl

Fri 1/30

2:45 pm-11:12 pm

1 stop8h 27m

$374

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:45 am-2:02 pm

1 stop7h 17m

Panama City Tocumen Intl

Wed 2/4

3:27 pm-11:36 pm

1 stop8h 09m

$391

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 9/1

7:00 am-12:45 am

2 stops18h 45m

Panama City Tocumen Intl

Sun 9/7

5:25 pm-12:45 pm

2 stops18h 20m

$391

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 12/1

4:59 pm-1:36 pm

2 stops20h 37m

Panama City Tocumen Intl

Sat 12/13

2:45 pm-8:31 am

2 stops17h 46m

$394

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Wed 9/17

5:37 pm-2:31 pm

2 stops21h 54m

Panama City Tocumen Intl

Sat 9/20

3:31 pm-11:19 am

2 stops18h 48m

$394

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 10/20

7:54 pm-2:03 pm

2 stops19h 09m

Panama City Tocumen Intl

Mon 10/27

3:15 pm-11:35 am

2 stops19h 20m

$394

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 1/21

6:24 pm-3:35 pm

2 stops21h 11m

Panama City Tocumen Intl

Wed 2/4

4:40 pm-10:33 am

2 stops17h 53m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 10/2

7:44 pm-2:31 pm

2 stops19h 47m

Panama City Tocumen Intl

Thu 10/9

3:15 pm-11:21 pm

1 stop7h 06m

$396

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 10/1

5:45 am-9:10 pm

2 stops16h 25m

Panama City Tocumen Intl

Wed 10/8

5:25 pm-12:39 pm

2 stops18h 14m

$397

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 10/16

6:15 am-9:10 pm

2 stops15h 55m

Panama City Tocumen Intl

Sun 10/26

5:55 pm-12:39 pm

2 stops17h 44m

$397

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/18

Showing 1-10 of 50 results

...

Best time to book a flight from South Carolina to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama City

What is the cheapest month to book a flight from South Carolina to Panama City?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $478). Flying from South Carolina to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to PTY?

When flying from South Carolina to Panama City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from South Carolina to Panama City?

Related info for your journey

What airport do you fly into for flights to Panama City from South Carolina?
Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Panama City from South Carolina.
How long is the flight from South Carolina to Panama City?
A quick flight from South Carolina to Panama City can take about 7h 17m. American Airlines provides one of the quickest options available for as low as $391. There are 1792 mi between South Carolina and Panama City. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines to fly from South Carolina to Panama City one-way?
The cheapest airlines for a one-way flight from South Carolina to Panama City are United Airlines ($169), American Airlines ($169), and Delta ($205).
What are the most popular routes from South Carolina to Panama City?
The most popular route from South Carolina to Panama City is Charlotte Douglas - Panama City Tocumen Intl. You may also consider Charleston - Panama City Tocumen Intl or Columbia Metropolitan - Panama City Tocumen Intl.
Can I find deals for flights from South Carolina to Panama City that include hotel bookings?
Yes. In addition to deals on South Carolina to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from South Carolina to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama City.
Can I find deals for business class flights from South Carolina to Panama City?
Yes. Cheapflights offers flight deals from South Carolina to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from South Carolina to Panama City?
Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $478). Flying from South Carolina to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from South Carolina to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$349	Average$588	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$352	Average$448	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$361	Average$554	FlexibilityNo cancel fee	On-time71%

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$167+ Cheap flights from South Carolina to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from South Carolina to Panama City

Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated August 18, 2025.

Round-trip from

One-way from

Find flight deals from South Carolina to Panama City

Cheapest flights from South Carolina to Panama CityExplore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Best time to book a flight from South Carolina to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama City

What is the cheapest month to book a flight from South Carolina to Panama City?

What is the cheapest time of day to fly from SC to PTY?

Find hourly flight availability from South Carolina to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 18, 2025.

How much does it cost to fly round-trip from South Carolina to Panama City?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Panama City from South Carolina?

How long is the flight from South Carolina to Panama City?

What are the cheapest airlines to fly from South Carolina to Panama City one-way?

What are the most popular routes from South Carolina to Panama City?

Can I find deals for flights from South Carolina to Panama City that include hotel bookings?

How can I find direct flights from South Carolina to Panama City?

Can I find deals for business class flights from South Carolina to Panama City?

What is the cheapest month to book a flight from South Carolina to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from South Carolina to Panama City

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Cheapest flights from South Carolina to Panama City
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.