$174+ Cheap flights from South Carolina to Panama City (PTY)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
apr. 12 — apr. 191
Round-trip
1 adult, Economy
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Cheapest flights from South Carolina to Panama CityExplore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on mars 13, 2026.
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on mars 13, 2026.
This Trip.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 4/176:30 am
CLT
- PTY
2 stops19h 05m
Multiple Airlines
sø. 4/263:10 pm
PTY
- CLT
2 stops19h 35m
Multiple Airlines
Deal found 3/11![Multiple Airlines logo]()
$403
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 4/110:55 am
CLT
- PTY
1 stop9h 25m
Multiple Airlines
on. 4/83:41 pm
PTY
- CLT
1 stop7h 44m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$419
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 4/116:00 am
CLT
- PTY
1 stop10h 54m
Multiple Airlines
sø. 4/269:33 pm
PTY
- CLT
1 stop13h 12m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$428
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 3/309:47 pm
CLT
- PTY
1 stop11h 19m
Multiple Airlines
ma. 4/69:33 pm
PTY
- CLT
1 stop13h 34m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$431
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 4/110:55 am
CLT
- PTY
1 stop9h 25m
Multiple Airlines
on. 4/159:33 pm
PTY
- CLT
1 stop13h 12m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$433
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 4/172:28 pm
CLT
- PTY
1 stop7h 07m
Multiple Airlines
sø. 4/199:33 pm
PTY
- CLT
1 stop13h 12m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$435
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 3/317:00 am
CLT
- PTY
1 stop14h 37m
Multiple Airlines
lø. 4/43:41 pm
PTY
- CLT
1 stop8h 12m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$436
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 4/297:25 am
CHS
- PTY
1 stop6h 37m
Delta
to. 5/72:15 pm
PTY
- CHS
1 stop8h 44m
Delta
Deal found 3/9![Delta logo]()
$441
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 4/108:42 pm
CLT
- PTY
1 stop12h 24m
Multiple Airlines
sø. 4/199:33 pm
PTY
- CLT
1 stop13h 12m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$442
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 3/287:00 am
CLT
- PTY
1 stop13h 20m
Multiple Airlines
lø. 4/43:41 pm
PTY
- CLT
1 stop8h 12m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$443
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 5/16:10 am
CLT
- PTY
1 stop7h 36m
American Airlines
on. 5/61:49 pm
PTY
- CLT
1 stop9h 10m
American Airlines
Deal found 3/9![American Airlines logo]()
$449
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 4/146:40 am
CHS
- PTY
1 stop10h 32m
United Airlines
ma. 4/2010:00 am
PTY
- CHS
1 stop10h 59m
United Airlines
Deal found 3/9![United Airlines logo]()
$461
Best flights from South Carolina to Panama CityDiscover carefully curated flight deals from South Carolina to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated mars 13, 2026.
Discover carefully curated flight deals from South Carolina to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated mars 13, 2026.
This Trip.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 4/176:30 am
CLT
- PTY
2 stops19h 05m
Multiple Airlines
sø. 4/265:30 am
PTY
- CLT
3 stops29h 15m
Multiple Airlines
Deal found 3/11![Multiple Airlines logo]()
$428
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 6/186:50 am
CHS
- PTY
1 stop12h 47m
United Airlines
ma. 6/227:55 am
PTY
- CHS
1 stop13h 20m
United Airlines
Deal found 3/9![United Airlines logo]()
$441
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 5/55:42 am
GSP
- PTY
1 stop8h 20m
Delta
to. 5/142:15 pm
PTY
- GSP
1 stop8h 28m
Delta
Deal found 3/10![Delta logo]()
$483
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sø. 4/266:39 pm
HHH
- PTY
2 stops19h 07m
American Airlines
sø. 5/31:49 pm
PTY
- HHH
2 stops19h 43m
American Airlines
Deal found 3/12![American Airlines logo]()
$616
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 4/157:44 pm
CHS
- PTY
2 stops21h 28m
United Airlines
on. 4/299:45 am
PTY
- CHS
2 stops13h 14m
United Airlines
Deal found 3/12![United Airlines logo]()
$465
This Trip.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 3/2810:17 am
CLT
- PTY
2 stops23h 58m
Multiple Airlines
fr. 4/33:05 am
PTY
- CLT
2 stops20h 48m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$498
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 4/148:00 am
CHS
- PTY
2 stops11h 37m
United Airlines
on. 4/1510:55 pm
PTY
- CHS
2 stops23h 37m
United Airlines
Deal found 3/10![United Airlines logo]()
$465
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 5/25:38 am
CAE
- PTY
1 stop8h 24m
Delta
to. 5/212:15 pm
PTY
- CAE
1 stop8h 27m
Delta
Deal found 3/9![Delta logo]()
$527
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 5/115:07 pm
CHS
- PTY
1 stop22h 07m
United Airlines
ma. 5/1810:00 am
PTY
- CHS
2 stops25h 17m
United Airlines
Deal found 3/11![United Airlines logo]()
$475
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 5/286:30 am
CLT
- PTY
3 stops20h 25m
Multiple Airlines
to. 6/116:15 pm
PTY
- CLT
1 stop16h 30m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$548
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 5/2310:39 pm
CLT
- PTY
1 stop14h 34m
American Airlines
lø. 5/301:14 pm
PTY
- CLT
1 stop18h 20m
American Airlines
Deal found 3/12![American Airlines logo]()
$627
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 4/137:40 pm
CHS
- PTY
1 stop9h 24m
United Airlines
sø. 4/1910:55 pm
PTY
- CHS
1 stop8h 56m
United Airlines
Deal found 3/11![United Airlines logo]()
$481
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 3/316:50 am
CAE
- PTY
1 stop7h 13m
Delta
to. 4/162:27 pm
PTY
- CAE
1 stop8h 29m
Delta
Deal found 3/9![Delta logo]()
$587
This KAYAK deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 7/24:00 pm
AGS
- PTY
1 stop22h 05m
LATAM Airlines
sø. 7/52:20 pm
PTY
- AGS
1 stop17h 58m
LATAM Airlines
Deal found 3/10![LATAM Airlines logo]()
$1,346
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 5/304:45 pm
CLT
- PTY
3 stops34h 10m
Multiple Airlines
on. 6/39:33 pm
PTY
- CLT
1 stop13h 12m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$576
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 4/14:31 pm
AGS
- PTY
2 stops21h 09m
American Airlines
on. 4/81:49 pm
PTY
- AGS
2 stops22h 29m
American Airlines
Deal found 3/11![American Airlines logo]()
$641
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 6/66:50 am
CHS
- PTY
1 stop8h 24m
United Airlines
sø. 6/143:30 pm
PTY
- CHS
1 stop29h 45m
United Airlines
Deal found 3/8![United Airlines logo]()
$490
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 4/255:40 am
AGS
- PTY
1 stop8h 22m
Delta
lø. 5/22:27 pm
PTY
- AGS
1 stop8h 31m
Delta
Deal found 3/11![Delta logo]()
$627
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 3/266:52 am
GSP
- PTY
1 stop12h 46m
United Airlines
on. 4/13:30 pm
PTY
- GSP
2 stops19h 24m
United Airlines
Deal found 3/12![United Airlines logo]()
$499
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 6/92:44 pm
CLT
- PTY
1 stop6h 53m
Multiple Airlines
sø. 6/149:33 pm
PTY
- CLT
1 stop10h 44m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$613
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 5/66:36 am
GSP
- PTY
2 stops13h 55m
United Airlines
fr. 5/810:55 pm
PTY
- GSP
2 stops17h 02m
United Airlines
Deal found 3/10![United Airlines logo]()
$505
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 6/1510:29 pm
CLT
- PTY
2 stops14h 44m
American Airlines
fr. 6/191:14 pm
PTY
- CLT
1 stop19h 40m
American Airlines
Deal found 3/13![American Airlines logo]()
$746
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 5/96:36 am
GSP
- PTY
2 stops13h 55m
United Airlines
on. 5/1310:00 am
PTY
- GSP
2 stops22h 58m
United Airlines
Deal found 3/10![United Airlines logo]()
$505
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 4/19:34 pm
CLT
- PTY
1 stop16h 06m
American Airlines
on. 4/81:49 pm
PTY
- CLT
2 stops15h 37m
American Airlines
Deal found 3/9![American Airlines logo]()
$760
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 5/277:00 am
GSP
- PTY
1 stop10h 12m
United Airlines
fr. 6/57:55 am
PTY
- GSP
2 stops25h 16m
United Airlines
Deal found 3/11![United Airlines logo]()
$505
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 5/1311:42 am
SAV
- PTY
1 stop7h 55m
United Airlines
ti. 5/197:55 am
PTY
- SAV
1 stop9h 27m
United Airlines
Deal found 3/8![United Airlines logo]()
$507
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 4/307:35 pm
GSP
- PTY
2 stops19h 39m
United Airlines
lø. 5/93:30 pm
PTY
- GSP
2 stops17h 17m
United Airlines
Deal found 3/10![United Airlines logo]()
$523
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 4/217:00 am
SAV
- PTY
1 stop8h 14m
United Airlines
ti. 4/287:55 am
PTY
- SAV
1 stop13h 04m
United Airlines
Deal found 3/8![United Airlines logo]()
$527
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 6/175:41 pm
GSP
- PTY
2 stops23h 31m
United Airlines
on. 6/243:30 pm
PTY
- GSP
2 stops24h 30m
United Airlines
Deal found 3/12![United Airlines logo]()
$530
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 4/16:50 am
AGS
- PTY
1 stop7h 13m
Delta
on. 4/82:28 pm
PTY
- AGS
1 stop7h 02m
Delta
Deal found 3/11![Delta logo]()
$1,322
Last-minute flights from South Carolina to Panama CityDiscover last-minute flight deals from South Carolina to Panama City. Data last updated mars 13, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Panama City. Data last updated mars 13, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 3/177:00 am
CLT
- PTY
1 stop10h 06m
Multiple Airlines
fr. 3/209:33 pm
PTY
- CLT
1 stop11h 14m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$452
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 3/287:00 am
CLT
- PTY
1 stop13h 20m
Multiple Airlines
lø. 4/43:41 pm
PTY
- CLT
1 stop8h 12m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$443
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 3/309:47 pm
CLT
- PTY
1 stop11h 19m
Multiple Airlines
ma. 4/69:33 pm
PTY
- CLT
1 stop13h 34m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$431
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 3/317:00 am
CLT
- PTY
1 stop14h 37m
Multiple Airlines
lø. 4/43:41 pm
PTY
- CLT
1 stop8h 12m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$436
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 4/110:55 am
CLT
- PTY
1 stop9h 25m
Multiple Airlines
on. 4/83:41 pm
PTY
- CLT
1 stop7h 44m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$419
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 4/110:55 am
CLT
- PTY
1 stop9h 25m
Multiple Airlines
on. 4/159:33 pm
PTY
- CLT
1 stop13h 12m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$433
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 4/108:42 pm
CLT
- PTY
1 stop12h 24m
Multiple Airlines
sø. 4/199:33 pm
PTY
- CLT
1 stop13h 12m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$442
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 4/116:00 am
CLT
- PTY
1 stop10h 54m
Multiple Airlines
sø. 4/269:33 pm
PTY
- CLT
1 stop13h 12m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$428
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 4/146:40 am
CHS
- PTY
1 stop10h 32m
United Airlines
ma. 4/2010:00 am
PTY
- CHS
1 stop10h 59m
United Airlines
Deal found 3/9![United Airlines logo]()
$461
This Trip.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 4/176:30 am
CLT
- PTY
2 stops19h 05m
Multiple Airlines
sø. 4/263:10 pm
PTY
- CLT
2 stops19h 35m
Multiple Airlines
Deal found 3/11![Multiple Airlines logo]()
$403
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 4/172:28 pm
CLT
- PTY
1 stop7h 07m
Multiple Airlines
sø. 4/199:33 pm
PTY
- CLT
1 stop13h 12m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$435
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 4/297:25 am
CHS
- PTY
1 stop6h 37m
Delta
to. 5/72:15 pm
PTY
- CHS
1 stop8h 44m
Delta
Deal found 3/9![Delta logo]()
$441
One-way flights from South Carolina to Panama CitySearch for one-way flight options from South Carolina to Panama City. Find affordable one-way fares based on user searches. Data last updated mars 13, 2026.
Search for one-way flight options from South Carolina to Panama City. Find affordable one-way fares based on user searches. Data last updated mars 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 5/116:30 am
CLT
- PTY
2 stops20h 25m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$174
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 4/93:08 pm
CLT
- PTY
2 stops24h 07m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 4/116:00 am
CLT
- PTY
3 stops20h 55m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$191
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 5/118:45 pm
CLT
- PTY
1 stop17h 01m
American Airlines
Deal found 3/12![American Airlines logo]()
$192
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 4/108:42 pm
CLT
- PTY
3 stops30h 13m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$196
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 4/156:30 am
GSP
- PTY
2 stops13h 07m
United Airlines
Deal found 3/10![United Airlines logo]()
$209
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sø. 4/267:00 am
GSP
- PTY
1 stop8h 14m
United Airlines
Deal found 3/12![United Airlines logo]()
$227
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 3/187:47 pm
CHS
- PTY
2 stops18h 58m
United Airlines
Deal found 3/10![United Airlines logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 4/86:15 am
CLT
- PTY
2 stops28h 00m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$233
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 3/216:52 am
GSP
- PTY
1 stop12h 46m
United Airlines
Deal found 3/12![United Airlines logo]()
$235
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 6/16:36 pm
SAV
- PTY
2 stops18h 37m
American Airlines
Deal found 3/9![American Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 4/234:55 pm
GSP
- PTY
3 stops41h 20m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$254
Find flight deals from South Carolina to Panama City
Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated mars 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $403 (Trip.com) |
One-way from | $174 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated mars 13, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
fr. 4/17
6:30 am-12:35 am
2 stops19h 05m
Panama City Tocumen Intl
sø. 4/26
5:30 am-11:45 am
3 stops29h 15m
$428
CharlestonPanama City
CHS - PTY
CHSPTY
Charleston
to. 6/18
6:50 am-6:37 pm
1 stop12h 47m
Panama City Tocumen Intl
ma. 6/22
7:55 am-10:15 pm
1 stop13h 20m
$441
CharlestonPanama City
CHS - PTY
CHSPTY
Charleston
on. 4/15
7:44 pm-4:12 pm
2 stops21h 28m
Panama City Tocumen Intl
on. 4/29
9:45 am-11:59 pm
2 stops13h 14m
$465
CharlestonPanama City
CHS - PTY
CHSPTY
Charleston
ti. 4/14
8:00 am-6:37 pm
2 stops11h 37m
Panama City Tocumen Intl
on. 4/15
10:55 pm-11:32 pm
2 stops23h 37m
$465
CharlestonPanama City
CHS - PTY
CHSPTY
Charleston
ma. 5/11
5:07 pm-2:14 pm
1 stop22h 07m
Panama City Tocumen Intl
ma. 5/18
10:00 am-12:17 pm
2 stops25h 17m
$475
CharlestonPanama City
CHS - PTY
CHSPTY
Charleston
ma. 4/13
7:40 pm-4:04 am
1 stop9h 24m
Panama City Tocumen Intl
sø. 4/19
10:55 pm-8:51 am
1 stop8h 56m
$481
GreenvillePanama City
GSP - PTY
GSPPTY
Greenville
ti. 5/5
5:42 am-1:02 pm
1 stop8h 20m
Panama City Tocumen Intl
to. 5/14
2:15 pm-11:43 pm
1 stop8h 28m
$483
CharlestonPanama City
CHS - PTY
CHSPTY
Charleston
lø. 6/6
6:50 am-2:14 pm
1 stop8h 24m
Panama City Tocumen Intl
sø. 6/14
3:30 pm-10:15 pm
1 stop29h 45m
$490
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
lø. 3/28
10:17 am-9:15 am
2 stops23h 58m
Panama City Tocumen Intl
fr. 4/3
3:05 am-12:53 am
2 stops20h 48m
$498
GreenvillePanama City
GSP - PTY
GSPPTY
Greenville
to. 3/26
6:52 am-6:38 pm
1 stop12h 46m
Panama City Tocumen Intl
on. 4/1
3:30 pm-11:54 am
2 stops19h 24m
$499
Showing 1-10 of 55 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
CLT-PTY
CHS-PTY
GSP-PTY
SAV-PTY
CAE-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Panama City
USSC-PTY
CLT-PTY
CHS-PTY
GSP-PTY
SAV-PTY
What is the cheapest month to book a flight from South Carolina to Panama City?
Currently, July is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $245). Flying from South Carolina to Panama City in December is currently the most expensive (average of $482). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
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Panama City flight routes
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Top destinations
Alternative routes for South Carolina to Panama City
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Panama City by cabin class
Find flights from South Carolina to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Panama City flights
Browse other South Carolina and Panama City flight options. Last updated on mars 13, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on mars 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Panama City flights
Consider these flights traveling from South Carolina to Panama City.
Top 3 airlines flying from South Carolina to Panama City
Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated mars 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$309 | Average$525 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$353 | Average$587 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$369 | Average$466 | FlexibilityNo cancel fee | On-time69% |