$297+ Cheap flights from South Carolina to Panama City (PTY)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Oct 23 — Oct 301
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Panama City with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to Panama CityExplore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
This Expedia deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:40 am -
2 stops18h 30m
Wed 12/95:30 am -
2 stops16h 52m
Deal found 9/21![Multiple Airlines logo]()
$582
This Expedia deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/119:40 am -
2 stops16h 30m
Mon 11/165:30 am -
2 stops14h 01m
Deal found 9/21![Multiple Airlines logo]()
$600
This Expedia deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:43 pm -
3 stops19h 12m
Fri 10/163:50 pm -
2 stops17h 25m
Deal found 9/18![Multiple Airlines logo]()
$606
This Expedia deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:43 pm -
3 stops19h 12m
Sat 10/245:30 am -
2 stops26h 14m
Deal found 9/20![Multiple Airlines logo]()
$616
This Travelocity deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/279:40 am -
2 stops17h 30m
Sat 10/313:55 pm -
2 stops40h 49m
Deal found 9/18![Multiple Airlines logo]()
$625
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/277:21 am -
1 stop7h 13m
Wed 12/23:13 pm -
1 stop6h 45m
Deal found 9/22![American Airlines logo]()
$627
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/212:15 pm -
2 stops28h 57m
Mon 12/78:55 am -
2 stops26h 08m
Deal found 9/22![United Airlines logo]()
$631
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/311:12 am -
1 stop8h 50m
Tue 11/108:55 am -
1 stop13h 04m
Deal found 9/19![United Airlines logo]()
$639
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/13:02 pm -
2 stops29h 00m
Mon 12/711:35 am -
2 stops22h 14m
Deal found 9/22![United Airlines logo]()
$640
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:49 am -
1 stop12h 49m
Wed 12/28:55 am -
1 stop13h 04m
Deal found 9/22![United Airlines logo]()
$657
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:19 pm -
1 stop18h 43m
Thu 11/263:29 pm -
1 stop6h 43m
Deal found 9/22![Delta logo]()
$664
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:05 am -
1 stop5h 54m
Thu 12/33:29 pm -
1 stop6h 53m
Deal found 9/21![Delta logo]()
$665
Best flights from South Carolina to Panama CityDiscover carefully curated flight deals from South Carolina to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
Discover carefully curated flight deals from South Carolina to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:56 pm -
2 stops24h 06m
Mon 12/711:35 am -
1 stop10h 24m
Deal found 9/19![United Airlines logo]()
$631
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:05 am -
1 stop5h 54m
Thu 12/33:29 pm -
1 stop6h 53m
Deal found 9/21![Delta logo]()
$665
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/15:06 pm -
2 stops20h 19m
Sun 2/284:04 pm -
2 stops19h 40m
Deal found 9/20![American Airlines logo]()
$683
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1211:12 am -
1 stop8h 50m
Tue 11/178:55 am -
2 stops29h 01m
Deal found 9/18![United Airlines logo]()
$631
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/186:30 am -
2 stops13h 32m
Mon 3/159:30 am -
1 stop12h 49m
Deal found 9/20![United Airlines logo]()
$649
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:00 am -
1 stop6h 59m
Mon 11/93:29 pm -
1 stop8h 24m
Deal found 9/18![Delta logo]()
$714
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:00 am -
1 stop13h 02m
Wed 11/410:00 am -
1 stop13h 59m
Deal found 9/20![United Airlines logo]()
$651
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:00 am -
1 stop8h 03m
Tue 12/153:29 pm -
1 stop8h 22m
Deal found 9/18![Delta logo]()
$732
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/16:46 pm -
2 stops22h 26m
Fri 3/1211:55 pm -
1 stop18h 11m
Deal found 9/22![United Airlines logo]()
$653
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:00 am -
1 stop6h 59m
Thu 11/123:29 pm -
1 stop8h 24m
Deal found 9/21![Delta logo]()
$786
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:40 am -
1 stop14h 22m
Tue 12/110:00 am -
1 stop13h 40m
Deal found 9/22![United Airlines logo]()
$657
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:10 am -
2 stops9h 03m
Tue 11/173:13 pm -
2 stops20h 29m
Deal found 9/18![American Airlines logo]()
$973
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:40 am -
1 stop14h 22m
Tue 12/110:00 am -
1 stop13h 40m
Deal found 9/22![United Airlines logo]()
$657
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/16:00 am -
1 stop7h 55m
Sun 2/283:20 pm -
1 stop8h 15m
Deal found 9/19![Delta logo]()
$820
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:49 am -
1 stop12h 49m
Wed 2/178:55 am -
1 stop12h 51m
Deal found 9/18![United Airlines logo]()
$657
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:40 am -
1 stop8h 19m
Sun 11/153:29 pm -
1 stop8h 24m
Deal found 9/19![Delta logo]()
$832
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:40 am -
1 stop14h 22m
Tue 12/18:55 am -
2 stops24h 57m
Deal found 9/22![United Airlines logo]()
$661
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
1 stop7h 59m
Sun 11/83:24 pm -
1 stop8h 23m
Deal found 9/20![Delta logo]()
$832
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:40 am -
1 stop14h 22m
Tue 11/1010:00 am -
1 stop13h 00m
Deal found 9/19![United Airlines logo]()
$665
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am -
1 stop7h 03m
Sun 12/133:29 pm -
1 stop8h 22m
Deal found 9/20![Delta logo]()
$839
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:56 pm -
2 stops24h 06m
Tue 12/158:55 am -
2 stops12h 26m
Deal found 9/19![United Airlines logo]()
$665
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:00 pm -
2 stops25h 02m
Tue 11/244:41 pm -
2 stops21h 15m
Deal found 9/19![United Airlines logo]()
$665
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/57:47 pm -
2 stops24h 15m
Fri 2/510:00 am -
2 stops23h 51m
Deal found 9/21![United Airlines logo]()
$674
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2111:30 am -
1 stop9h 01m
Tue 1/194:41 pm -
1 stop29h 05m
Deal found 9/22![United Airlines logo]()
$676
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:45 pm -
2 stops21h 00m
Tue 12/1510:00 am -
1 stop25h 45m
Deal found 9/18![United Airlines logo]()
$740
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1211:27 am -
1 stop8h 35m
Tue 11/1710:00 am -
1 stop24h 21m
Deal found 9/18![United Airlines logo]()
$749
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2012:02 pm -
1 stop8h 29m
Sat 11/148:55 am -
2 stops25h 04m
Deal found 9/22![United Airlines logo]()
$759
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2110:23 am -
2 stops10h 08m
Sat 11/148:55 am -
2 stops25h 04m
Deal found 9/22![United Airlines logo]()
$759
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:38 pm -
2 stops21h 36m
Mon 11/94:41 pm -
2 stops21h 36m
Deal found 9/22![United Airlines logo]()
$804
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:38 pm -
2 stops21h 36m
Thu 11/1210:00 am -
1 stop25h 41m
Deal found 9/22![United Airlines logo]()
$838
Last-minute flights from South Carolina to Panama CityDiscover last-minute flight deals from South Carolina to Panama City. Data last updated September 23, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Panama City. Data last updated September 23, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:08 am -
2 stops24h 22m
Mon 9/283:50 pm -
2 stops17h 27m
Deal found 9/18![Multiple Airlines logo]()
$687
This Expedia deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:43 pm -
3 stops19h 12m
Fri 10/163:50 pm -
2 stops17h 25m
Deal found 9/18![Multiple Airlines logo]()
$606
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:44 pm -
2 stops19h 18m
Thu 10/222:02 pm -
1 stop8h 57m
Deal found 9/19![American Airlines logo]()
$688
This Expedia deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:43 pm -
3 stops19h 12m
Sat 10/245:30 am -
2 stops26h 14m
Deal found 9/20![Multiple Airlines logo]()
$616
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1910:23 am -
2 stops10h 08m
Wed 11/1110:00 am -
2 stops23h 59m
Deal found 9/22![United Airlines logo]()
$699
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2011:05 am -
1 stop9h 26m
Tue 10/277:55 am -
1 stop13h 04m
Deal found 9/22![United Airlines logo]()
$651
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2012:02 pm -
1 stop8h 29m
Wed 11/1110:00 am -
2 stops23h 59m
Deal found 9/22![United Airlines logo]()
$697
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop14h 31m
Tue 1/194:41 pm -
2 stops28h 05m
Deal found 9/22![United Airlines logo]()
$669
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:59 pm -
2 stops20h 03m
Wed 11/113:13 pm -
2 stops19h 00m
Deal found 9/22![American Airlines logo]()
$689
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:38 pm -
2 stops26h 53m
Wed 11/1110:00 am -
2 stops23h 59m
Deal found 9/22![United Airlines logo]()
$722
This Travelocity deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/279:40 am -
2 stops17h 30m
Sat 10/313:55 pm -
2 stops40h 49m
Deal found 9/18![Multiple Airlines logo]()
$625
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:12 am -
1 stop8h 50m
Sat 10/313:41 pm -
2 stops22h 47m
Deal found 9/18![United Airlines logo]()
$690
One-way flights from South Carolina to Panama CitySearch for one-way flight options from South Carolina to Panama City. Find affordable one-way fares based on user searches. Data last updated September 23, 2026.
Search for one-way flight options from South Carolina to Panama City. Find affordable one-way fares based on user searches. Data last updated September 23, 2026.
This Expedia deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/711:09 am -
3 stops28h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$297
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/116:00 am -
1 stop7h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Delta logo]()
$302
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/115:55 pm -
2 stops22h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![American Airlines logo]()
$318
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:20 am -
2 stops13h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![United Airlines logo]()
$352
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:00 am -
1 stop14h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![United Airlines logo]()
$355
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:00 am -
1 stop12h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![United Airlines logo]()
$370
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/116:12 pm -
3 stops40h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$411
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:32 pm -
2 stops17h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$421
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:52 pm -
3 stops24h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Multiple Airlines logo]()
$429
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2012:02 pm -
1 stop8h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![United Airlines logo]()
$447
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/206:45 am -
3 stops37h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$454
This KAYAK deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/48:28 pm -
2 stops17h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![GOL logo]()
$483
Find flight deals from South Carolina to Panama City
Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated September 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $582 (Expedia) |
One-way from | $297 (Expedia) |
Popular in | November |
Cheapest in | March |
Average price | $777 |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 23, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Myrtle BeachPanama City
MYR Myrtle Beach Intl - PTY Panama City Tocumen Intl
MYRPTY
Myrtle Beach Intl
Mon 1/11
6:00 am-1:55 pm
1 stop7h 55m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$302
CharlestonPanama City
CHS Charleston - PTY Panama City Tocumen Intl
CHSPTY
Charleston
Wed 10/7
11:09 am-10:30 am
2 stops24h 21m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$312
Myrtle BeachPanama City
MYR Myrtle Beach Intl - PTY Panama City Tocumen Intl
MYRPTY
Myrtle Beach Intl
Mon 1/11
5:55 pm-3:55 pm
2 stops22h 00m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$318
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Fri 10/30
6:20 am-6:38 pm
2 stops13h 18m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$352
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Mon 10/5
6:00 am-7:31 pm
1 stop14h 31m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$355
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Tue 10/6
6:00 am-7:31 pm
1 stop14h 31m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$355
CharlestonPanama City
CHS Charleston - PTY Panama City Tocumen Intl
CHSPTY
Charleston
Wed 10/7
7:00 am-6:37 pm
1 stop12h 37m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$370
Myrtle BeachPanama City
MYR Myrtle Beach Intl - PTY Panama City Tocumen Intl
MYRPTY
Myrtle Beach Intl
Mon 1/11
6:12 pm-10:40 am
3 stops40h 28m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$411
ColumbiaPanama City
CAE Columbia Metropolitan - PTY Panama City Tocumen Intl
CAEPTY
Columbia Metropolitan
Thu 12/10
8:32 pm-2:13 pm
2 stops17h 41m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$421
ColumbiaPanama City
CAE Columbia Metropolitan - PTY Panama City Tocumen Intl
CAEPTY
Columbia Metropolitan
Tue 10/20
5:18 pm-1:02 pm
2 stops20h 44m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$447
Showing 1-10 of 46 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
MYR-PTY
CHS-PTY
GSP-PTY
CAE-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Panama City
USSC-PTY
MYR-PTY
CHS-PTY
GSP-PTY
CAE-PTY
What is the cheapest month to book a flight from South Carolina to Panama City?
Currently, March is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $487). Flying from South Carolina to Panama City in December is currently the most expensive (average of $838). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from South Carolina to Panama City?
Airfare is typical for this route at the moment.
South Carolina to Panama City flights typically cost between $530 and $762 in December.The cheapest round-trip price found within the last 5 days was $582 on Multiple Airlines (Dec 4-Dec 9).
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
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Panama City flight routes
Popular flights
Top destinations
Alternative routes for South Carolina to Panama City
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Panama City by cabin class
Find flights from South Carolina to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Panama City flights
Browse other South Carolina and Panama City flight options. Last updated on September 23, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Panama City flights
Consider these flights traveling from South Carolina to Panama City.
Top 3 airlines flying from South Carolina to Panama City
Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$299 | Average$639 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$369 | Average$630 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$399 | Average$696 | FlexibilityNo cancel fee | On-time71% |