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Panama City

$196+ Cheap flights from South Carolina to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
oct. 17 — oct. 241
vie. 10/17
vie. 10/24
1 adult, Economy
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Cheap flight deals from South Carolina to Panama City

Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated septiembre 17, 2025.

Round-trip from

$369
(Delta)

One-way from

$196
(Kiwi.com)
From South Carolina to Panama City Tocumen Intl
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One-way flight from South Carolina to Panama City Tocumen Intl
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Find flight deals from South Carolina to Panama City

Cheapest flights from South Carolina to Panama City
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 17, 2025.

This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/276:30 amCHS - PTY
1 stop13h 08mUnited Airlines
mar. 11/258:55 amPTY - CHS
1 stop13h 04mUnited Airlines
Deal found 9/14$369
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/35:39 pmCHS - PTY
2 stops20h 10mAmerican Airlines
vie. 11/72:49 pmPTY - CHS
2 stops17h 40mAmerican Airlines
Deal found 9/16$374
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/268:03 pmCHS - PTY
1 stop17h 53mDelta
lun. 11/243:37 pmPTY - CHS
1 stop7h 11mDelta
Deal found 9/14$376
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/306:30 amCHS - PTY
1 stop13h 08mUnited Airlines
jue. 11/274:41 pmPTY - CHS
1 stop23h 35mUnited Airlines
Deal found 9/14$378
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/157:41 pmCHS - PTY
2 stops19h 22mAmerican Airlines
mié. 10/223:15 pmPTY - CHS
2 stops16h 01mAmerican Airlines
Deal found 9/16$382
This Avianca Connect deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/225:45 amCLT - PTY
2 stops20h 00mMultiple Airlines
dom. 10/262:55 amPTY - CLT
2 stops19h 33mMultiple Airlines
Deal found 9/17$388
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/275:35 amCHS - PTY
1 stop8h 21mDelta
sáb. 11/223:37 pmPTY - CHS
1 stop8h 20mDelta
Deal found 9/14$389
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/115:00 amGSP - PTY
1 stop8h 49mAmerican Airlines
jue. 11/202:43 pmPTY - GSP
1 stop9h 16mAmerican Airlines
Deal found 9/15$391
This Vliegwinkel deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Vliegwinkel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/301:49 pmCLT - PTY
1 stop7h 48mMultiple Airlines
jue. 11/68:25 amPTY - CLT
1 stop7h 36mMultiple Airlines
Deal found 9/15$392
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/296:30 amCHS - PTY
2 stops8h 33mAmerican Airlines
lun. 11/242:43 pmPTY - CHS
2 stops21h 12mAmerican Airlines
Deal found 9/14$394
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/205:30 amCLT - PTY
1 stop8h 26mDelta
jue. 10/232:21 pmPTY - CLT
1 stop8h 29mDelta
Deal found 9/16$395
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/268:03 pmCHS - PTY
1 stop17h 53mDelta
sáb. 11/228:05 amPTY - CHS
1 stop7h 12mDelta
Deal found 9/14$396

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

South Carolina

Fly to

Panama City

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mié. 10/29

6:40 am-12:56 pm

1 stop7h 16m

Panama City Tocumen Intl

jue. 11/27

3:37 pm-10:48 pm

1 stop7h 11m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mié. 10/29

6:00 am-1:55 pm

1 stop8h 55m

Panama City Tocumen Intl

mar. 11/25

8:55 am-9:59 pm

1 stop13h 04m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mié. 10/29

6:40 am-12:56 pm

1 stop7h 16m

Panama City Tocumen Intl

lun. 11/24

3:37 pm-11:57 pm

1 stop8h 20m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

lun. 10/27

6:30 am-6:38 pm

1 stop13h 08m

Panama City Tocumen Intl

mar. 11/25

8:55 am-9:59 pm

1 stop13h 04m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mar. 10/28

5:35 am-12:56 pm

1 stop8h 21m

Panama City Tocumen Intl

jue. 11/27

3:37 pm-10:48 pm

1 stop7h 11m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

jue. 10/30

6:30 am-6:38 pm

1 stop13h 08m

Panama City Tocumen Intl

mar. 11/25

8:55 am-9:59 pm

1 stop13h 04m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mar. 10/28

5:35 am-12:56 pm

1 stop8h 21m

Panama City Tocumen Intl

mié. 11/26

3:37 pm-11:57 pm

1 stop8h 20m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

lun. 11/3

5:09 pm-1:49 pm

2 stops20h 40m

Panama City Tocumen Intl

vie. 11/7

2:49 pm-12:23 pm

2 stops21h 34m

$374

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mar. 10/28

6:40 am-12:56 pm

1 stop7h 16m

Panama City Tocumen Intl

mar. 11/25

3:37 pm-9:31 am

1 stop17h 54m

$376

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

dom. 10/26

8:03 pm-12:56 pm

1 stop17h 53m

Panama City Tocumen Intl

jue. 11/27

3:37 pm-10:48 pm

1 stop7h 11m

$376

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Showing 1-10 of 40 results
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Best time to book a flight from South Carolina to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama City

What is the cheapest month to book a flight from South Carolina to Panama City?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $478). Flying from South Carolina to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to PTY?

Find hourly flight availability from South Carolina to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 17, 2025.

When flying from South Carolina to Panama City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from South Carolina?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Panama City from South Carolina.

  • How long is the flight from South Carolina to Panama City?

    A quick flight from South Carolina to Panama City can take about 7h 16m. Delta provides one of the quickest options available for as low as $369. There are 1645 mi between South Carolina and Panama City. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from South Carolina to Panama City?

    The most popular route from South Carolina to Panama City is Charlotte Douglas - Panama City Tocumen Intl. You may also consider Columbia Metropolitan - Panama City Tocumen Intl or Charleston - Panama City Tocumen Intl.

  • Can I find deals for flights from South Carolina to Panama City that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama City.

  • Can I find deals for business class flights from South Carolina to Panama City?

    Yes. Cheapflights offers flight deals from South Carolina to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama City?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $478). Flying from South Carolina to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Panama City

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Top 3 airlines flying from South Carolina to Panama City

Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$352Average$439FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$361Average$553FlexibilityNo cancel feeOn-time71%
DeltaCheapest$369Average$575FlexibilityNo cancel feeOn-timeN/A

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