How long is the flight from South Carolina to Panama City?

A quick flight from South Carolina to Panama City can take about 9h 02m. United Airlines provides one of the quickest options available for as low as $378. There are 1645 mi between South Carolina and Panama City. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the most popular routes from South Carolina to Panama City?

The most popular route from South Carolina to Panama City is Charlotte Douglas - Panama City Tocumen Intl. You may also consider Charleston - Panama City Tocumen Intl or Myrtle Beach Intl - Panama City Tocumen Intl.

What are the most popular airlines that fly from South Carolina to Panama City?

Delta, American Airlines and United Airlines are the most popular airlines when flying from South Carolina to Panama City.

What airport do you fly into for flights to Panama City from South Carolina?

Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Panama City from South Carolina.

Can I find deals for flights from South Carolina to Panama City that include hotel bookings?

Yes. In addition to deals on South Carolina to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from South Carolina to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama City.

Can I find deals for business class flights from South Carolina to Panama City?

Yes. Cheapflights offers flight deals from South Carolina to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$169+ Flights from South Carolina to Panama City

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Cheap flight deals from South Carolina to Panama City

Cheapest flights from South Carolina to Panama City
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 15, 2025.

lun. 12/156:33 amCLT - PTY

1 stop7h 48mDelta

mar. 12/163:46 pmPTY - CLT

1 stop7h 56mDelta

Deal found 12/13

$404

lun. 12/154:51 pmCLT - PTY

1 stop24h 16mUnited Airlines

jue. 12/188:55 amPTY - CLT

1 stop12h 47mUnited Airlines

Deal found 12/15

$412

lun. 12/155:15 amCLT - PTY

1 stop8h 32mAmerican Airlines

mar. 12/162:50 pmPTY - CLT

2 stops15h 39mAmerican Airlines

Deal found 12/13

$468

lun. 12/155:15 amCLT - PTY

1 stop10h 27mAmerican Airlines

jue. 12/184:55 pmPTY - CLT

2 stops13h 38mAmerican Airlines

Deal found 12/14

$508

vie. 12/196:45 amGSP - PTY

1 stop8h 00mUnited Airlines

dom. 12/218:55 amPTY - GSP

1 stop8h 08mUnited Airlines

Deal found 12/15

$558

mié. 12/177:58 pmCLT - PTY

1 stop19h 56mAmerican Airlines

vie. 12/194:55 pmPTY - CLT

1 stop15h 16mAmerican Airlines

Deal found 12/13

$558

sáb. 12/278:04 pmGSP - PTY

1 stop19h 50mAmerican Airlines

mié. 12/314:55 pmPTY - GSP

2 stops17h 52mAmerican Airlines

Deal found 12/15

$563

lun. 12/225:44 pmGSP - PTY

1 stop21h 01mUnited Airlines

mar. 1/64:41 pmPTY - GSP

1 stop29h 16mUnited Airlines

Deal found 12/15

$566

sáb. 12/134:51 pmCLT - PTY

1 stop26h 47mUnited Airlines

lun. 1/124:41 pmPTY - CLT

1 stop18h 04mUnited Airlines

Deal found 12/13

$575

mié. 12/177:58 pmCLT - PTY

1 stop19h 56mAmerican Airlines

mar. 3/173:13 pmPTY - CLT

1 stop21h 18mAmerican Airlines

Deal found 12/13

$588

jue. 12/256:22 amCLT - PTY

1 stop8h 23mUnited Airlines

mié. 12/3111:55 pmPTY - CLT

1 stop9h 19mUnited Airlines

Deal found 12/14

$598

vie. 12/194:45 pmCLT - PTY

1 stop26h 53mUnited Airlines

mar. 12/234:41 pmPTY - CLT

1 stop29h 01mUnited Airlines

Deal found 12/14

$628

Best flights from South Carolina to Panama City
Discover carefully curated flight deals from South Carolina to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated diciembre 15, 2025.

lun. 1/2611:00 amCHS - PTY

1 stop9h 02mUnited Airlines

jue. 1/294:41 pmPTY - CHS

1 stop29h 16mUnited Airlines

Deal found 12/12

$378

sáb. 3/147:02 pmCHS - PTY

2 stops20h 20mAmerican Airlines

mar. 3/171:44 pmPTY - CHS

2 stops19h 33mAmerican Airlines

Deal found 12/15

$394

lun. 4/66:58 pmMYR - PTY

1 stop18h 57mDelta

jue. 4/162:20 pmPTY - MYR

1 stop26h 38mDelta

Deal found 12/14

$450

mar. 2/247:00 amCLT - PTY

2 stops18h 00mMultiple Airlines

sáb. 2/282:55 amPTY - CLT

2 stops15h 07mMultiple Airlines

Deal found 12/13

$472

mié. 1/216:49 amGSP - PTY

1 stop12h 49mUnited Airlines

mié. 2/49:55 amPTY - GSP

1 stop12h 02mUnited Airlines

Deal found 12/14

$392

mié. 1/217:42 pmGSP - PTY

2 stops19h 56mAmerican Airlines

mié. 2/42:27 pmPTY - GSP

2 stops21h 40mAmerican Airlines

Deal found 12/14

$396

mié. 1/286:49 amGSP - PTY

1 stop10h 18mUnited Airlines

mié. 2/49:55 amPTY - GSP

1 stop12h 02mUnited Airlines

Deal found 12/14

$392

mié. 1/286:23 pmGSP - PTY

2 stops19h 04mAmerican Airlines

mié. 2/42:27 pmPTY - GSP

1 stop9h 30mAmerican Airlines

Deal found 12/14

$396

sáb. 5/25:40 amCAE - PTY

1 stop8h 15mDelta

jue. 5/212:20 pmPTY - CAE

1 stop8h 35mDelta

Deal found 12/13

$456

mar. 1/274:40 pmGSP - PTY

2 stops20h 47mAmerican Airlines

mar. 2/172:50 pmPTY - GSP

2 stops21h 27mAmerican Airlines

Deal found 12/14

$396

lun. 1/56:45 amGSP - PTY

1 stop12h 53mUnited Airlines

jue. 1/154:41 pmPTY - GSP

1 stop29h 16mUnited Airlines

Deal found 12/12

$406

lun. 2/95:25 amCLT - PTY

1 stop8h 30mDelta

mié. 2/113:20 pmPTY - CLT

1 stop17h 20mDelta

Deal found 12/15

$468

lun. 1/194:50 pmGSP - PTY

1 stop24h 17mUnited Airlines

jue. 1/224:41 pmPTY - GSP

1 stop29h 16mUnited Airlines

Deal found 12/13

$408

vie. 4/107:03 pmGSP - PTY

2 stops18h 12mAmerican Airlines

mié. 4/151:55 pmPTY - GSP

2 stops18h 57mAmerican Airlines

Deal found 12/14

$414

mar. 5/197:50 pmMYR - PTY

1 stop18h 05mDelta

vie. 5/222:20 pmPTY - MYR

1 stop20h 59mDelta

Deal found 12/15

$470

jue. 1/86:30 amCHS - PTY

1 stop10h 37mUnited Airlines

jue. 1/154:41 pmPTY - CHS

1 stop23h 36mUnited Airlines

Deal found 12/13

$410

vie. 1/167:42 pmCHS - PTY

2 stops20h 10mAmerican Airlines

dom. 2/14:50 pmPTY - CHS

1 stop15h 57mAmerican Airlines

Deal found 12/13

$419

vie. 1/165:13 pmCHS - PTY

1 stop26h 25mUnited Airlines

dom. 2/14:41 pmPTY - CHS

1 stop29h 16mUnited Airlines

Deal found 12/13

$427

mar. 1/274:33 pmSAV - PTY

2 stops20h 54mAmerican Airlines

mar. 2/32:27 pmPTY - SAV

1 stop9h 31mAmerican Airlines

Deal found 12/13

$460

lun. 5/186:00 amMYR - PTY

1 stop7h 55mDelta

mié. 5/272:20 pmPTY - MYR

1 stop8h 18mDelta

Deal found 12/15

$578

mar. 1/2711:43 amSAV - PTY

1 stop7h 55mUnited Airlines

mar. 2/38:55 amPTY - SAV

1 stop9h 10mUnited Airlines

Deal found 12/13

$456

sáb. 5/26:33 pmCAE - PTY

2 stops18h 42mAmerican Airlines

jue. 5/211:50 pmPTY - CAE

2 stops19h 17mAmerican Airlines

Deal found 12/13

$460

mar. 4/77:00 amCAE - PTY

1 stop6h 55mDelta

jue. 4/162:20 pmPTY - CAE

1 stop8h 35mDelta

Deal found 12/12

$578

dom. 2/17:33 pmAGS - PTY

2 stops37h 47mWestJet

jue. 2/510:20 amPTY - AGS

2 stops32h 32mWestJet

Deal found 12/14

$1,707

jue. 1/227:10 pmCAE - PTY

2 stops18h 17mAmerican Airlines

jue. 2/122:50 pmPTY - CAE

2 stops19h 37mAmerican Airlines

Deal found 12/12

$460

lun. 2/166:33 amCLT - PTY

1 stop8h 12mUnited Airlines

jue. 2/2610:00 amPTY - CLT

1 stop11h 09mUnited Airlines

Deal found 12/15

$468

lun. 4/66:58 pmMYR - PTY

1 stop18h 57mDelta

mié. 4/152:20 pmPTY - MYR

1 stop8h 18mDelta

Deal found 12/14

$585

jue. 1/296:21 pmCAE - PTY

2 stops19h 06mAmerican Airlines

jue. 2/52:27 pmPTY - CAE

2 stops19h 15mAmerican Airlines

Deal found 12/15

$460

mar. 2/246:33 amCLT - PTY

1 stop8h 12mUnited Airlines

mié. 2/254:41 pmPTY - CLT

1 stop18h 06mUnited Airlines

Deal found 12/15

$468

dom. 5/177:50 pmMYR - PTY

1 stop18h 05mDelta

mié. 5/272:20 pmPTY - MYR

1 stop8h 18mDelta

Deal found 12/15

$585

Last-minute flights from South Carolina to Panama City
Discover last-minute flight deals from South Carolina to Panama City. Data last updated diciembre 15, 2025 and is based on user searches.

lun. 12/156:45 amCLT - PTY

1 stop10h 22mUnited Airlines

jue. 12/188:55 amPTY - CLT

1 stop12h 47mUnited Airlines

Deal found 12/14

$404

lun. 1/56:45 amGSP - PTY

1 stop12h 53mUnited Airlines

jue. 1/154:41 pmPTY - GSP

1 stop29h 16mUnited Airlines

Deal found 12/12

$406

mié. 1/74:50 pmGSP - PTY

1 stop24h 17mUnited Airlines

jue. 1/154:41 pmPTY - GSP

1 stop29h 16mUnited Airlines

Deal found 12/12

$414

jue. 1/87:42 pmCHS - PTY

2 stops19h 56mAmerican Airlines

jue. 1/152:27 pmPTY - CHS

2 stops19h 21mAmerican Airlines

Deal found 12/13

$406

jue. 1/86:30 amCHS - PTY

1 stop10h 37mUnited Airlines

jue. 1/154:41 pmPTY - CHS

1 stop23h 36mUnited Airlines

Deal found 12/13

$410

vie. 1/96:49 amGSP - PTY

1 stop10h 18mUnited Airlines

jue. 1/154:41 pmPTY - GSP

1 stop29h 16mUnited Airlines

Deal found 12/12

$418

lun. 1/127:00 pmGSP - PTY

2 stops18h 27mAmerican Airlines

lun. 1/192:27 pmPTY - GSP

2 stops21h 40mAmerican Airlines

Deal found 12/15

$421

vie. 1/165:41 pmCHS - PTY

2 stops19h 46mAmerican Airlines

dom. 2/14:50 pmPTY - CHS

2 stops16h 58mAmerican Airlines

Deal found 12/13

$419

lun. 1/194:50 pmGSP - PTY

1 stop26h 48mUnited Airlines

jue. 1/224:41 pmPTY - GSP

1 stop22h 54mUnited Airlines

Deal found 12/14

$408

mié. 1/216:49 amGSP - PTY

1 stop10h 18mUnited Airlines

mié. 2/49:55 amPTY - GSP

1 stop12h 02mUnited Airlines

Deal found 12/15

$392

mié. 1/216:23 pmGSP - PTY

2 stops21h 15mAmerican Airlines

mié. 2/42:27 pmPTY - GSP

2 stops20h 57mAmerican Airlines

Deal found 12/15

$396

lun. 1/2611:00 amCHS - PTY

1 stop9h 02mUnited Airlines

jue. 1/2911:35 amPTY - CHS

1 stop28h 42mUnited Airlines

Deal found 12/14

$378

One-way flights from South Carolina to Panama City
Search for one-way flight options from South Carolina to Panama City. Find affordable one-way fares based on user searches. Data last updated diciembre 15, 2025.

mar. 12/306:45 amGSP - PTY

1 stop12h 53mUnited Airlines

Deal found 12/15

$169

lun. 2/96:31 pmCLT - PTY

2 stops19h 29mMultiple Airlines

Deal found 12/15

$180

dom. 12/287:59 pmGSP - PTY

1 stop24h 01mDelta

Deal found 12/15

$181

mar. 1/66:30 amCHS - PTY

1 stop8h 15mUnited Airlines

Deal found 12/14

$184

vie. 1/25:45 amGSP - PTY

1 stop8h 12mDelta

Deal found 12/15

$189

dom. 2/89:19 pmCLT - PTY

2 stops16h 41mMultiple Airlines

Deal found 12/15

$192

mié. 1/72:57 pmCLT - PTY

2 stops27h 58mMultiple Airlines

Deal found 12/13

$195

jue. 3/126:00 amSAV - PTY

1 stop7h 40mAmerican Airlines

Deal found 12/13

$205

mar. 2/105:54 pmCLT - PTY

3 stops20h 06mMultiple Airlines

Deal found 12/15

$213

jue. 1/15:39 amGSP - PTY

2 stops10h 15mAmerican Airlines

Deal found 12/15

$218

lun. 2/95:25 amCLT - PTY

1 stop8h 30mDelta

Deal found 12/15

$221

mar. 12/309:02 amGSP - PTY

2 stops28h 51mAmerican Airlines

Deal found 12/15

$224

Find flight deals from South Carolina to Panama City

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$378 (United Airlines)
One-way from	$169 (United Airlines)

Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.

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From South Carolina to Panama City Tocumen Intl

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One-way flight from South Carolina to Panama City Tocumen Intl

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Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

lun. 1/26

11:00 am-8:02 pm

1 stop9h 02m

Panama City Tocumen Intl

jue. 1/29

4:41 pm-9:57 pm

1 stop29h 16m

$378

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 1/21

6:49 am-7:38 pm

1 stop12h 49m

Panama City Tocumen Intl

mié. 2/4

9:55 am-9:57 pm

1 stop12h 02m

$392

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 1/28

6:49 am-5:07 pm

1 stop10h 18m

Panama City Tocumen Intl

mié. 2/4

9:55 am-9:57 pm

1 stop12h 02m

$392

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

sáb. 3/14

7:02 pm-2:22 pm

2 stops20h 20m

Panama City Tocumen Intl

mar. 3/17

1:44 pm-10:17 am

2 stops19h 33m

$394

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 1/21

7:42 pm-3:38 pm

2 stops19h 56m

Panama City Tocumen Intl

mié. 2/4

2:27 pm-12:07 pm

2 stops21h 40m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 1/28

6:23 pm-1:27 pm

2 stops19h 04m

Panama City Tocumen Intl

mié. 2/4

2:27 pm-11:57 pm

1 stop9h 30m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mar. 1/27

4:40 pm-1:27 pm

2 stops20h 47m

Panama City Tocumen Intl

mar. 2/17

2:50 pm-12:17 pm

2 stops21h 27m

$396

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

lun. 1/5

6:45 am-7:38 pm

1 stop12h 53m

Panama City Tocumen Intl

jue. 1/15

4:41 pm-9:57 pm

1 stop29h 16m

$406

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

lun. 1/19

4:50 pm-5:07 pm

1 stop24h 17m

Panama City Tocumen Intl

jue. 1/22

4:41 pm-9:57 pm

1 stop29h 16m

$408

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

jue. 1/8

6:30 am-5:07 pm

1 stop10h 37m

Panama City Tocumen Intl

jue. 1/15

4:41 pm-4:17 pm

1 stop23h 36m

$410

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 60 results

...

Best time to book a flight from South Carolina to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama City

What is the cheapest month to book a flight from South Carolina to Panama City?

Currently, July is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $230). Flying from South Carolina to Panama City in May is currently the most expensive (average of $419). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to PTY?

It’s optimal to fly from South Carolina to Panama City in the afternoon. By choosing this option you can save up to 10% on the cost of your flight, compared to a flight at noon.

Related info for your journey

What airport do you fly into for flights to Panama City from South Carolina?
Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Panama City from South Carolina.
How long is the flight from South Carolina to Panama City?
A quick flight from South Carolina to Panama City can take about 9h 02m. United Airlines provides one of the quickest options available for as low as $378. There are 1645 mi between South Carolina and Panama City. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the most popular routes from South Carolina to Panama City?
The most popular route from South Carolina to Panama City is Charlotte Douglas - Panama City Tocumen Intl. You may also consider Charleston - Panama City Tocumen Intl or Myrtle Beach Intl - Panama City Tocumen Intl.
Can I find deals for flights from South Carolina to Panama City that include hotel bookings?
Yes. In addition to deals on South Carolina to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from South Carolina to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama City.
Can I find deals for business class flights from South Carolina to Panama City?
Yes. Cheapflights offers flight deals from South Carolina to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from South Carolina to Panama City?
Currently, July is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $230). Flying from South Carolina to Panama City in May is currently the most expensive (average of $419). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from South Carolina to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$349	Average$521	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$353	Average$559	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$369	Average$446	FlexibilityNo cancel fee	On-time69%

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$169+ Cheap flights from South Carolina to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/30. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from South Carolina to Panama City

Cheapest flights from South Carolina to Panama CityExplore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 15, 2025.

Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 15, 2025.

Find flight deals from South Carolina to Panama City

Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated diciembre 15, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Best time to book a flight from South Carolina to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama City

What is the cheapest month to book a flight from South Carolina to Panama City?

What is the cheapest time of day to fly from SC to PTY?

Find hourly flight availability from South Carolina to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 15, 2025.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Panama City from South Carolina?

How long is the flight from South Carolina to Panama City?

What are the most popular routes from South Carolina to Panama City?

Can I find deals for flights from South Carolina to Panama City that include hotel bookings?

How can I find direct flights from South Carolina to Panama City?

Can I find deals for business class flights from South Carolina to Panama City?

What is the cheapest month to book a flight from South Carolina to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from South Carolina to Panama City

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Cheapest flights from South Carolina to Panama City
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 15, 2025.