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Panama City

$164+ Cheap flights from South Carolina to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/28. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from South Carolina to Panama City

Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated June 12, 2025.

Round-trip from

$369
(United Airlines)

One-way from

$164
(Delta)

Popular in

February

Cheapest in

August

Average price

$651
From South Carolina to Panama City Tocumen Intl
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One-way flight from South Carolina to Panama City Tocumen Intl
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Highest demand for flights based on searches. 7% potential increase in price ($49 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from South Carolina to Panama City

Cheapest flights from South Carolina to Panama City
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/246:15 amCHS - PTY
1 stop8h 35mUnited Airlines
Tue 7/297:55 amPTY - CHS
1 stop13h 50mUnited Airlines
Deal found 6/10$369
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/196:18 pmCHS - PTY
2 stops21h 12mAmerican Airlines
Fri 8/293:30 pmPTY - CHS
2 stops21h 20mAmerican Airlines
Deal found 6/9$374
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/286:45 amGSP - PTY
1 stop12h 53mUnited Airlines
Wed 11/58:55 amPTY - GSP
1 stop13h 04mUnited Airlines
Deal found 6/12$391
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/136:44 pmGSP - PTY
2 stops20h 46mAmerican Airlines
Tue 8/193:30 pmPTY - GSP
2 stops19h 11mAmerican Airlines
Deal found 6/12$396
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/127:59 pmGSP - PTY
1 stop24h 31mDelta
Fri 6/202:23 pmPTY - GSP
1 stop8h 34mDelta
Deal found 6/12$450
This Avianca Connect deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/269:32 pmCLT - PTY
2 stops16h 03mMultiple Airlines
Sun 6/291:30 pmPTY - CLT
2 stops17h 39mMultiple Airlines
Deal found 6/12$452
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/37:00 amCLT - PTY
1 stop6h 52mDelta
Wed 12/103:17 pmPTY - CLT
1 stop17h 21mDelta
Deal found 6/11$457
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/129:10 amSAV - PTY
1 stop8h 02mUnited Airlines
Tue 8/197:55 amPTY - SAV
1 stop13h 04mUnited Airlines
Deal found 6/10$467
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2810:25 pmCLT - PTY
1 stop17h 05mAmerican Airlines
Tue 9/23:30 pmPTY - CLT
1 stop16h 43mAmerican Airlines
Deal found 6/12$467
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/127:28 pmSAV - PTY
2 stops20h 02mAmerican Airlines
Tue 8/193:30 pmPTY - SAV
2 stops19h 07mAmerican Airlines
Deal found 6/12$472
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/56:30 amCLT - PTY
1 stop8h 15mUnited Airlines
Wed 12/104:40 pmPTY - CLT
1 stop18h 12mUnited Airlines
Deal found 6/11$487
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/227:34 pmCAE - PTY
2 stops19h 56mAmerican Airlines
Fri 8/293:30 pmPTY - CAE
2 stops17h 22mAmerican Airlines
Deal found 6/11$492

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

South Carolina

Fly to

Panama City

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 7/24

6:15 am-1:50 pm

1 stop8h 35m

Panama City Tocumen Intl

Tue 7/29

7:55 am-10:45 pm

1 stop13h 50m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 8/19

6:18 pm-2:30 pm

2 stops21h 12m

Panama City Tocumen Intl

Fri 8/29

3:30 pm-1:50 pm

2 stops21h 20m

$374

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 10/28

6:45 am-6:38 pm

1 stop12h 53m

Panama City Tocumen Intl

Wed 11/5

8:55 am-9:59 pm

1 stop13h 04m

$391

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 8/13

6:44 pm-2:30 pm

2 stops20h 46m

Panama City Tocumen Intl

Tue 8/19

3:30 pm-11:41 am

2 stops19h 11m

$396

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 6/26

9:32 pm-12:35 pm

2 stops16h 03m

Panama City Tocumen Intl

Sun 6/29

1:30 pm-8:09 am

2 stops17h 39m

$452

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 12/3

7:00 am-1:52 pm

1 stop6h 52m

Panama City Tocumen Intl

Wed 12/10

3:17 pm-8:38 am

1 stop17h 21m

$457

SavannahPanama City

SAV - PTY

SAVPTY

Savannah/Hilton Head

Tue 8/12

9:10 am-4:12 pm

1 stop8h 02m

Panama City Tocumen Intl

Tue 8/19

7:55 am-9:59 pm

1 stop13h 04m

$467

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 8/28

10:25 pm-2:30 pm

1 stop17h 05m

Panama City Tocumen Intl

Tue 9/2

3:30 pm-9:13 am

1 stop16h 43m

$467

SavannahPanama City

SAV - PTY

SAVPTY

Savannah/Hilton Head

Tue 8/12

7:28 pm-2:30 pm

2 stops20h 02m

Panama City Tocumen Intl

Tue 8/19

3:30 pm-11:37 am

2 stops19h 07m

$472

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Fri 12/5

6:30 am-2:45 pm

1 stop8h 15m

Panama City Tocumen Intl

Wed 12/10

4:40 pm-10:52 am

1 stop18h 12m

$487

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Showing 1-10 of 37 results
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Best time to book a flight from South Carolina to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama City

What is the cheapest month to book a flight from South Carolina to Panama City?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $478). Flying from South Carolina to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to PTY?

Find hourly flight availability from South Carolina to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

When flying from South Carolina to Panama City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated June 12, 2025.
See what other customers who have flown with Alaska Airlines, Delta and United Airlines from South Carolina to Panama City have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Crew

8.5

Overall

8.0

Comfort

7.8

Boarding

8.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

Surinder,May 2025

SEA - YYZ

My wife wanted the aile seat and I always prefer window seat. Luckily we both got the best seats we wanted. The plane was very nice and we enjoyed the best take off and the smooth landing at Toronto. All the services by the staff inside the aeroplane were very nice well appreciated. Thanks again and hope to see you soon.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Crew

8.5

Overall

8.0

Comfort

7.8

Boarding

8.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

Surinder,May 2025

SEA - YYZ

My wife wanted the aile seat and I always prefer window seat. Luckily we both got the best seats we wanted. The plane was very nice and we enjoyed the best take off and the smooth landing at Toronto. All the services by the staff inside the aeroplane were very nice well appreciated. Thanks again and hope to see you soon.
Delta
8.0
Very good
7,950 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Crew

8.5

Overall

8.0

Comfort

7.8

Boarding

8.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

Surinder,May 2025

SEA - YYZ

My wife wanted the aile seat and I always prefer window seat. Luckily we both got the best seats we wanted. The plane was very nice and we enjoyed the best take off and the smooth landing at Toronto. All the services by the staff inside the aeroplane were very nice well appreciated. Thanks again and hope to see you soon.
United Airlines
7.4
Good
8,790 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Crew

8.5

Overall

8.0

Comfort

7.8

Boarding

8.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

Surinder,May 2025

SEA - YYZ

My wife wanted the aile seat and I always prefer window seat. Luckily we both got the best seats we wanted. The plane was very nice and we enjoyed the best take off and the smooth landing at Toronto. All the services by the staff inside the aeroplane were very nice well appreciated. Thanks again and hope to see you soon.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Crew

8.5

Overall

8.0

Comfort

7.8

Boarding

8.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

Surinder,May 2025

SEA - YYZ

My wife wanted the aile seat and I always prefer window seat. Luckily we both got the best seats we wanted. The plane was very nice and we enjoyed the best take off and the smooth landing at Toronto. All the services by the staff inside the aeroplane were very nice well appreciated. Thanks again and hope to see you soon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from South Carolina?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Panama City from South Carolina.

  • What are the cheapest airlines to fly from South Carolina to Panama City one-way?

    The cheapest airlines for a one-way flight from South Carolina to Panama City are Delta ($164), United Airlines ($169), and American Airlines ($198).

  • What are the most popular routes from South Carolina to Panama City?

    The most popular route from South Carolina to Panama City is Charlotte Douglas - Panama City Tocumen Intl. You may also consider Greenville - Panama City Tocumen Intl or Charleston - Panama City Tocumen Intl.

  • Can I find deals for flights from South Carolina to Panama City that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama City.

  • Can I find deals for business class flights from South Carolina to Panama City?

    Yes. Cheapflights offers flight deals from South Carolina to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama City?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $478). Flying from South Carolina to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Panama City

Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$285Average$406FlexibilityNo cancel feeOn-time69%
DeltaCheapest$331Average$591FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$352Average$562FlexibilityNo cancel feeOn-time71%

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