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Panama City

$142+ Cheap flights from South Carolina to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/28. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from South Carolina to Panama City

Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated May 1, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$349
(Delta)

One-way from

$142
(Delta)

Popular in

March

Cheapest in

June

Average price

$437
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
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From South Carolina to Panama City Tocumen Intl
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One-way flight from South Carolina to Panama City Tocumen Intl
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Highest demand for flights based on searches. 22% potential increase in price ($176 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($18 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from South Carolina to Panama City

Cheapest flights from South Carolina to Panama City
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/37:39 amCHS - PTY
1 stop6h 09mDelta
Tue 6/102:23 pmPTY - CHS
1 stop8h 36mDelta
Deal found 4/29$349
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/38:43 pmCHS - PTY
2 stops16h 36mAmerican Airlines
Tue 6/101:50 pmPTY - CHS
2 stops19h 46mAmerican Airlines
Deal found 4/29$354
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/135:45 amGSP - PTY
1 stop8h 09mDelta
Tue 8/192:12 pmPTY - GSP
1 stop8h 33mDelta
Deal found 4/29$371
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/137:39 pmGSP - PTY
2 stops19h 41mAmerican Airlines
Tue 8/193:40 pmPTY - GSP
2 stops24h 06mAmerican Airlines
Deal found 4/29$376
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/511:26 amGSP - PTY
1 stop9h 05mUnited Airlines
Thu 5/83:30 pmPTY - GSP
1 stop29h 45mUnited Airlines
Deal found 4/29$392
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:36 pmAGS - PTY
2 stops20h 44mAmerican Airlines
Tue 11/112:45 pmPTY - AGS
2 stops19h 29mAmerican Airlines
Deal found 4/29$420
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/288:27 pmCAE - PTY
2 stops17h 27mAmerican Airlines
Wed 7/301:55 pmPTY - CAE
2 stops19h 16mAmerican Airlines
Deal found 4/29$420
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/37:00 amCHS - PTY
1 stop10h 12mUnited Airlines
Mon 5/510:00 amPTY - CHS
1 stop10h 40mUnited Airlines
Deal found 4/29$433
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:21 pmSAV - PTY
2 stops18h 59mAmerican Airlines
Mon 12/152:45 pmPTY - SAV
2 stops19h 40mAmerican Airlines
Deal found 4/29$440
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2811:47 amCLT - PTY
1 stop7h 50mUnited Airlines
Wed 7/307:55 amPTY - CLT
1 stop13h 02mUnited Airlines
Deal found 4/29$447
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/59:02 amCLT - PTY
1 stop8h 24mMultiple Airlines
Wed 6/116:32 pmPTY - CLT
1 stop12h 45mMultiple Airlines
Deal found 4/29$449
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/275:58 pmCLT - PTY
1 stop20h 05mDelta
Thu 7/312:23 pmPTY - CLT
1 stop8h 35mDelta
Deal found 4/29$454

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

South Carolina

Fly to

Panama City

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 6/3

7:39 am-12:48 pm

1 stop6h 09m

Panama City Tocumen Intl

Tue 6/10

2:23 pm-11:59 pm

1 stop8h 36m

$349

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 6/3

8:43 pm-12:19 pm

2 stops16h 36m

Panama City Tocumen Intl

Tue 6/10

1:50 pm-10:36 am

2 stops19h 46m

$354

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 8/13

5:45 am-12:54 pm

1 stop8h 09m

Panama City Tocumen Intl

Tue 8/19

2:12 pm-11:45 pm

1 stop8h 33m

$371

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 8/13

7:39 pm-2:20 pm

2 stops19h 41m

Panama City Tocumen Intl

Tue 8/19

3:40 pm-4:46 pm

2 stops24h 06m

$376

ColumbiaPanama City

CAE - PTY

CAEPTY

Columbia Metropolitan

Mon 7/28

8:27 pm-12:54 pm

2 stops17h 27m

Panama City Tocumen Intl

Wed 7/30

1:55 pm-10:11 am

2 stops19h 16m

$420

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Wed 6/11

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Mon 6/16

3:30 pm-10:00 pm

1 stop29h 30m

$443

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 7/28

6:52 am-1:03 pm

1 stop7h 11m

Panama City Tocumen Intl

Tue 7/29

2:23 pm-8:56 am

1 stop17h 33m

$447

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 6/5

9:02 am-4:26 pm

1 stop8h 24m

Panama City Tocumen Intl

Wed 6/11

6:32 pm-8:17 am

1 stop12h 45m

$449

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sun 5/25

6:05 am-4:12 pm

1 stop11h 07m

Panama City Tocumen Intl

Sat 5/31

10:00 am-10:15 pm

1 stop11h 15m

$453

AugustaPanama City

AGS - PTY

AGSPTY

Augusta Bush Field

Mon 7/28

12:45 pm-12:54 pm

2 stops25h 09m

Panama City Tocumen Intl

Thu 7/31

1:55 pm-5:43 pm

2 stops26h 48m

$460

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 27 results
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Best time to book a flight from South Carolina to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama City

What is the cheapest month to book a flight from South Carolina to Panama City?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $478). Flying from South Carolina to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to PTY?

Find hourly flight availability from South Carolina to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

When flying from South Carolina to Panama City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated May 1, 2025.
See what other customers who have flown with Delta, United Airlines and American Airlines from South Carolina to Panama City have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,317 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from South Carolina?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Panama City from South Carolina.

  • What are the cheapest airlines to fly from South Carolina to Panama City one-way?

    The cheapest airlines for a one-way flight from South Carolina to Panama City are Delta ($142), American Airlines ($148), and United Airlines ($301).

  • What are the most popular routes from South Carolina to Panama City?

    The most popular route from South Carolina to Panama City is Charlotte Douglas - Panama City Tocumen Intl. You may also consider Greenville - Panama City Tocumen Intl or Charleston - Panama City Tocumen Intl.

  • Can I find deals for flights from South Carolina to Panama City that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama City.

  • Can I find deals for business class flights from South Carolina to Panama City?

    Yes. Cheapflights offers flight deals from South Carolina to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama City?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $478). Flying from South Carolina to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Panama City

Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$281Average$403FlexibilityNo cancel feeOn-time69%
DeltaCheapest$331Average$588FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$351Average$557FlexibilityNo cancel feeOn-time71%

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