$167+ Cheap flights from South Carolina to Panama City (PTY)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/11. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Apr 25 — May 21
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from South Carolina to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Panama City
Cheapest
Best
Last-minute
One-way
Cheapest flights from South Carolina to Panama CityExplore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2026.
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2026.
This Trip.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:30 am
CLT
- PTY
2 stops19h 05m
Multiple Airlines
Sun 4/2610:10 am
PTY
- CLT
2 stops24h 35m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$394
This Trip.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:30 am
CLT
- PTY
2 stops19h 05m
Multiple Airlines
Sat 5/95:30 am
PTY
- CLT
3 stops29h 15m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$396
This Trip.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:30 am
CLT
- PTY
3 stops20h 25m
Multiple Airlines
Sun 5/175:30 am
PTY
- CLT
3 stops29h 15m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$412
This Trip.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:30 am
CLT
- PTY
2 stops19h 05m
Multiple Airlines
Sat 5/25:55 pm
PTY
- CLT
2 stops16h 50m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$418
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:30 am
CLT
- PTY
1 stop10h 24m
Multiple Airlines
Sun 4/269:33 pm
PTY
- CLT
1 stop13h 12m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$432
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:05 am
CLT
- PTY
1 stop8h 41m
American Airlines
Fri 5/221:14 pm
PTY
- CLT
2 stops16h 08m
American Airlines
Deal found 3/24![American Airlines logo]()
$440
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:30 am
CLT
- PTY
1 stop15h 05m
Multiple Airlines
Fri 5/88:10 am
PTY
- CLT
1 stop8h 03m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$442
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/317:00 am
CLT
- PTY
1 stop14h 37m
Multiple Airlines
Tue 4/73:41 pm
PTY
- CLT
1 stop7h 44m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$446
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:25 pm
CLT
- PTY
1 stop16h 55m
American Airlines
Tue 8/183:20 pm
PTY
- CLT
1 stop14h 49m
American Airlines
Deal found 3/23![American Airlines logo]()
$449
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:17 am
CLT
- PTY
1 stop10h 03m
American Airlines
Wed 8/193:20 pm
PTY
- CLT
2 stops14h 09m
American Airlines
Deal found 3/25![American Airlines logo]()
$453
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:15 am
CHS
- PTY
1 stop8h 35m
Delta
Wed 5/202:15 pm
PTY
- CHS
1 stop18h 23m
Delta
Deal found 3/23![Delta logo]()
$460
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:00 am
CHS
- PTY
1 stop7h 46m
American Airlines
Fri 5/151:49 pm
PTY
- CHS
1 stop9h 35m
American Airlines
Deal found 3/23![American Airlines logo]()
$467
Best flights from South Carolina to Panama CityDiscover carefully curated flight deals from South Carolina to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 26, 2026.
Discover carefully curated flight deals from South Carolina to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 26, 2026.
This Trip.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:30 am
CLT
- PTY
2 stops19h 05m
Multiple Airlines
Sun 5/174:25 am
PTY
- CLT
2 stops30h 20m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$394
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:15 am
CHS
- PTY
1 stop8h 35m
Delta
Wed 5/202:15 pm
PTY
- CHS
1 stop18h 23m
Delta
Deal found 3/23![Delta logo]()
$460
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:50 am
CHS
- PTY
1 stop12h 47m
United Airlines
Tue 8/1810:55 pm
PTY
- CHS
1 stop8h 57m
United Airlines
Deal found 3/23![United Airlines logo]()
$467
This American Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:16 am
CLT
- PTY
1 stop9h 54m
American Airlines
Sun 9/203:40 pm
PTY
- CLT
1 stop15h 42m
American Airlines
Deal found 3/22![American Airlines logo]()
$484
This Gurufare deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2310:50 am
CAE
- PTY
2 stops18h 14m
Copa Airlines
Thu 4/303:30 pm
PTY
- CAE
2 stops17h 18m
Copa Airlines
Deal found 3/24![Copa Airlines logo]()
$581
This KAYAK deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:40 am
AGS
- PTY
1 stop8h 22m
LATAM Airlines
Sat 4/252:27 pm
PTY
- AGS
1 stop17h 49m
LATAM Airlines
Deal found 3/22![LATAM Airlines logo]()
$653
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:00 am
CHS
- PTY
2 stops13h 37m
United Airlines
Wed 5/209:45 am
PTY
- CHS
2 stops13h 14m
United Airlines
Deal found 3/24![United Airlines logo]()
$471
This American Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:49 pm
GSP
- PTY
2 stops19h 21m
American Airlines
Thu 10/153:35 pm
PTY
- GSP
1 stop6h 39m
American Airlines
Deal found 3/22![American Airlines logo]()
$501
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:30 am
CLT
- PTY
1 stop9h 00m
Multiple Airlines
Mon 5/119:33 pm
PTY
- CLT
2 stops15h 06m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$514
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/135:30 am
CLT
- PTY
1 stop8h 32m
Delta
Mon 4/272:27 pm
PTY
- CLT
1 stop8h 26m
Delta
Deal found 3/25![Delta logo]()
$519
This United Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:00 am
CHS
- PTY
1 stop8h 14m
United Airlines
Sun 8/2310:55 pm
PTY
- CHS
1 stop8h 57m
United Airlines
Deal found 3/22![United Airlines logo]()
$494
This Mytrip deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:30 am
CLT
- PTY
2 stops32h 45m
Multiple Airlines
Fri 5/110:10 am
PTY
- CLT
2 stops33h 39m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$524
This American Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2010:52 am
GSP
- PTY
2 stops26h 21m
American Airlines
Sat 5/301:14 pm
PTY
- GSP
2 stops20h 36m
American Airlines
Deal found 3/21![American Airlines logo]()
$525
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/47:35 pm
GSP
- PTY
2 stops24h 02m
United Airlines
Thu 5/710:00 am
PTY
- GSP
2 stops22h 47m
United Airlines
Deal found 3/24![United Airlines logo]()
$507
This Delta deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:50 am
AGS
- PTY
1 stop7h 12m
Delta
Wed 5/132:15 pm
PTY
- AGS
1 stop8h 37m
Delta
Deal found 3/22![Delta logo]()
$567
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:12 pm
GSP
- PTY
2 stops20h 34m
American Airlines
Wed 5/61:49 pm
PTY
- GSP
2 stops17h 46m
American Airlines
Deal found 3/24![American Airlines logo]()
$550
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:33 pm
CLT
- PTY
2 stops15h 42m
Multiple Airlines
Sun 5/1712:15 pm
PTY
- CLT
1 stop22h 50m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$550
This United Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:30 am
GSP
- PTY
2 stops22h 34m
United Airlines
Mon 4/273:30 pm
PTY
- GSP
2 stops17h 16m
United Airlines
Deal found 3/21![United Airlines logo]()
$507
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:00 am
MYR
- PTY
2 stops8h 46m
American Airlines
Fri 5/151:49 pm
PTY
- MYR
2 stops21h 15m
American Airlines
Deal found 3/24![American Airlines logo]()
$551
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:50 am
CAE
- PTY
1 stop7h 12m
Delta
Thu 5/212:15 pm
PTY
- CAE
1 stop8h 34m
Delta
Deal found 3/23![Delta logo]()
$617
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:50 am
CHS
- PTY
1 stop12h 47m
United Airlines
Sat 7/117:55 am
PTY
- CHS
1 stop13h 20m
United Airlines
Deal found 3/25![United Airlines logo]()
$521
This American Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/68:08 pm
AGS
- PTY
2 stops17h 38m
American Airlines
Wed 5/131:49 pm
PTY
- AGS
2 stops21h 38m
American Airlines
Deal found 3/22![American Airlines logo]()
$551
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:00 am
MYR
- PTY
1 stop7h 50m
Delta
Fri 5/152:15 pm
PTY
- MYR
1 stop8h 43m
Delta
Deal found 3/24![Delta logo]()
$627
This United Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:35 pm
GSP
- PTY
2 stops21h 37m
United Airlines
Thu 5/143:30 pm
PTY
- GSP
1 stop29h 44m
United Airlines
Deal found 3/22![United Airlines logo]()
$532
This American Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:05 am
CLT
- PTY
1 stop8h 41m
American Airlines
Sat 5/301:14 pm
PTY
- CLT
1 stop18h 20m
American Airlines
Deal found 3/21![American Airlines logo]()
$551
This Expedia deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/210:42 am
SAV
- PTY
2 stops24h 48m
Multiple Airlines
Fri 7/3111:25 am
PTY
- SAV
3 stops29h 28m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$703
This Delta deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/47:59 pm
CLT
- PTY
1 stop18h 14m
Delta
Sun 9/62:28 pm
PTY
- CLT
1 stop17h 10m
Delta
Deal found 3/22![Delta logo]()
$650
This United Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:50 am
CHS
- PTY
1 stop8h 24m
United Airlines
Sun 6/1410:55 pm
PTY
- CHS
1 stop8h 56m
United Airlines
Deal found 3/22![United Airlines logo]()
$538
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:03 pm
CAE
- PTY
2 stops19h 11m
American Airlines
Sun 5/311:14 pm
PTY
- CAE
2 stops21h 48m
American Airlines
Deal found 3/24![American Airlines logo]()
$566
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:49 pm
GSP
- PTY
1 stop9h 15m
United Airlines
Mon 7/1310:55 pm
PTY
- GSP
2 stops17h 05m
United Airlines
Deal found 3/24![United Airlines logo]()
$539
Last-minute flights from South Carolina to Panama CityDiscover last-minute flight deals from South Carolina to Panama City. Data last updated March 26, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Panama City. Data last updated March 26, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/266:45 am
GSP
- PTY
1 stop7h 18m
Delta
Wed 4/12:28 pm
PTY
- GSP
1 stop8h 26m
Delta
Deal found 3/24![Delta logo]()
$535
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/317:00 am
CLT
- PTY
1 stop14h 37m
Multiple Airlines
Tue 4/73:41 pm
PTY
- CLT
1 stop7h 44m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$446
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/110:55 am
CLT
- PTY
1 stop9h 25m
Multiple Airlines
Wed 4/88:10 am
PTY
- CLT
1 stop15h 15m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$456
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/110:55 am
CLT
- PTY
1 stop10h 40m
Multiple Airlines
Mon 4/610:25 am
PTY
- CLT
1 stop9h 09m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$472
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/110:55 am
CLT
- PTY
1 stop10h 40m
Multiple Airlines
Tue 4/73:41 pm
PTY
- CLT
1 stop7h 44m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$477
This United Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/17:42 pm
GSP
- PTY
2 stops19h 32m
United Airlines
Wed 4/83:30 pm
PTY
- GSP
2 stops17h 16m
United Airlines
Deal found 3/22![United Airlines logo]()
$519
This Trip.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:30 am
CLT
- PTY
2 stops19h 05m
Multiple Airlines
Sun 4/2610:10 am
PTY
- CLT
2 stops24h 35m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:30 am
GSP
- PTY
2 stops22h 34m
United Airlines
Mon 4/273:30 pm
PTY
- GSP
2 stops17h 16m
United Airlines
Deal found 3/21![United Airlines logo]()
$507
This Trip.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:30 am
CLT
- PTY
2 stops19h 05m
Multiple Airlines
Sat 5/95:30 am
PTY
- CLT
3 stops29h 15m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$396
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:30 am
CLT
- PTY
1 stop10h 24m
Multiple Airlines
Sun 4/269:33 pm
PTY
- CLT
1 stop13h 12m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$432
This Trip.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:30 am
CLT
- PTY
2 stops19h 05m
Multiple Airlines
Sat 5/25:55 pm
PTY
- CLT
2 stops16h 50m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$418
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:30 am
CLT
- PTY
1 stop15h 05m
Multiple Airlines
Fri 5/88:10 am
PTY
- CLT
1 stop8h 03m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$442
One-way flights from South Carolina to Panama CitySearch for one-way flight options from South Carolina to Panama City. Find affordable one-way fares based on user searches. Data last updated March 26, 2026.
Search for one-way flight options from South Carolina to Panama City. Find affordable one-way fares based on user searches. Data last updated March 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:00 am
CLT
- PTY
2 stops28h 15m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$167
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:45 am
CLT
- PTY
2 stops27h 30m
Multiple Airlines
Deal found 3/23![Multiple Airlines logo]()
$168
This Mytrip deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:30 am
CLT
- PTY
2 stops27h 45m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$189
This American Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/510:25 pm
CLT
- PTY
1 stop16h 55m
American Airlines
Deal found 3/21![American Airlines logo]()
$192
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:30 am
CLT
- PTY
2 stops32h 45m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$193
This Mytrip deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/127:00 am
CLT
- PTY
3 stops28h 30m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:30 am
CLT
- PTY
3 stops20h 25m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/314:45 pm
CLT
- PTY
2 stops17h 30m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$210
This United Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:00 am
GSP
- PTY
1 stop8h 14m
United Airlines
Deal found 3/22![United Airlines logo]()
$215
This American Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:12 pm
GSP
- PTY
2 stops20h 34m
American Airlines
Deal found 3/22![American Airlines logo]()
$219
This United Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:40 am
CHS
- PTY
1 stop12h 57m
United Airlines
Deal found 3/22![United Airlines logo]()
$240
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:26 pm
SAV
- PTY
2 stops18h 47m
American Airlines
Deal found 3/24![American Airlines logo]()
$251
Find flight deals from South Carolina to Panama City
Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated March 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $394 (Trip.com) |
One-way from | $167 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
Thu 5/14
6:30 am-12:35 am
2 stops19h 05m
Panama City Tocumen Intl
Sun 5/17
4:25 am-11:45 am
2 stops30h 20m
$394
CharlestonPanama City
CHS - PTY
CHSPTY
Charleston
Thu 5/14
5:15 am-12:50 pm
1 stop8h 35m
Panama City Tocumen Intl
Wed 5/20
2:15 pm-9:38 am
1 stop18h 23m
$460
CharlestonPanama City
CHS - PTY
CHSPTY
Charleston
Mon 8/10
6:50 am-6:37 pm
1 stop12h 47m
Panama City Tocumen Intl
Tue 8/18
10:55 pm-8:52 am
1 stop8h 57m
$467
CharlestonPanama City
CHS - PTY
CHSPTY
Charleston
Wed 5/13
6:00 am-6:37 pm
2 stops13h 37m
Panama City Tocumen Intl
Wed 5/20
9:45 am-11:59 pm
2 stops13h 14m
$471
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
Thu 9/17
5:16 am-2:10 pm
1 stop9h 54m
Panama City Tocumen Intl
Sun 9/20
3:40 pm-8:22 am
1 stop15h 42m
$484
CharlestonPanama City
CHS - PTY
CHSPTY
Charleston
Mon 8/17
7:00 am-2:14 pm
1 stop8h 14m
Panama City Tocumen Intl
Sun 8/23
10:55 pm-8:52 am
1 stop8h 57m
$494
GreenvillePanama City
GSP - PTY
GSPPTY
Greenville
Tue 9/15
7:49 pm-2:10 pm
2 stops19h 21m
Panama City Tocumen Intl
Thu 10/15
3:35 pm-11:14 pm
1 stop6h 39m
$501
GreenvillePanama City
GSP - PTY
GSPPTY
Greenville
Mon 5/4
7:35 pm-6:37 pm
2 stops24h 02m
Panama City Tocumen Intl
Thu 5/7
10:00 am-9:47 am
2 stops22h 47m
$507
GreenvillePanama City
GSP - PTY
GSPPTY
Greenville
Mon 4/20
6:30 am-4:04 am
2 stops22h 34m
Panama City Tocumen Intl
Mon 4/27
3:30 pm-9:46 am
2 stops17h 16m
$507
CharlottePanama City
CLT - PTY
CLTPTY
Charlotte Douglas
Fri 5/8
6:30 am-2:30 pm
1 stop9h 00m
Panama City Tocumen Intl
Mon 5/11
9:33 pm-1:39 pm
2 stops15h 06m
$514
Showing 1-10 of 58 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
CLT-PTY
CHS-PTY
CAE-PTY
AGS-PTY
GSP-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Panama City
USSC-PTY
CLT-PTY
CHS-PTY
CAE-PTY
AGS-PTY
What is the cheapest month to book a flight from South Carolina to Panama City?
Currently, July is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $245). Flying from South Carolina to Panama City in December is currently the most expensive (average of $482). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from South Carolina to Panama City?
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Panama City flight routes
Popular flights
Top destinations
Alternative routes for South Carolina to Panama City
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Panama City by cabin class
Find flights from South Carolina to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Panama City flights
Browse other South Carolina and Panama City flight options. Last updated on March 26, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Panama City flights
Consider these flights traveling from South Carolina to Panama City.
Top 3 airlines flying from South Carolina to Panama City
Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$309 | Average$519 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$353 | Average$579 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$369 | Average$513 | FlexibilityNo cancel fee | On-time69% |