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Panama City

$152+ Cheap flights from South Carolina to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/5. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
nov. 28 — dic. 51
vie. 11/28
vie. 12/5
1 adult, Economy
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Find flight deals from South Carolina to Panama City

Cheapest flights from South Carolina to Panama City
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 29, 2025.

This Avianca Connect deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/159:57 pmCLT - PTY
2 stops10h 53mMultiple Airlines
mar. 11/182:55 pmPTY - CLT
2 stops22h 05mMultiple Airlines
Deal found 10/27$352
This Avianca Connect deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/187:59 pmCLT - PTY
2 stops18h 01mMultiple Airlines
dom. 11/232:55 pmPTY - CLT
2 stops17h 54mMultiple Airlines
Deal found 10/27$372
This Avianca Connect deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/139:38 pmCLT - PTY
2 stops16h 22mMultiple Airlines
mar. 11/185:50 pmPTY - CLT
2 stops19h 10mMultiple Airlines
Deal found 10/26$373
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/117:53 pmCHS - PTY
2 stops19h 49mAmerican Airlines
jue. 12/182:53 pmPTY - CHS
2 stops17h 42mAmerican Airlines
Deal found 10/27$374
This Avianca Connect deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/278:52 pmCLT - PTY
2 stops17h 08mMultiple Airlines
mié. 12/32:55 amPTY - CLT
2 stops16h 15mMultiple Airlines
Deal found 10/28$382
This Avianca Connect deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/79:38 pmCLT - PTY
2 stops16h 22mMultiple Airlines
mié. 11/265:50 pmPTY - CLT
2 stops14h 59mMultiple Airlines
Deal found 10/28$391
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/105:10 amGSP - PTY
1 stop8h 37mAmerican Airlines
mar. 12/162:50 pmPTY - GSP
1 stop9h 09mAmerican Airlines
Deal found 10/27$392
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/105:10 amGSP - PTY
1 stop8h 37mAmerican Airlines
mar. 1/132:27 pmPTY - GSP
2 stops21h 40mAmerican Airlines
Deal found 10/28$396
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/195:00 amGSP - PTY
1 stop8h 49mAmerican Airlines
mié. 11/262:43 pmPTY - GSP
1 stop9h 16mAmerican Airlines
Deal found 10/29$398
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/76:33 amCLT - PTY
1 stop7h 48mDelta
mar. 12/93:46 pmPTY - CLT
1 stop7h 56mDelta
Deal found 10/27$400
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/45:00 amGSP - PTY
1 stop8h 49mAmerican Airlines
mié. 11/52:49 pmPTY - GSP
1 stop9h 10mAmerican Airlines
Deal found 10/29$404
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/85:15 amCLT - PTY
1 stop8h 32mAmerican Airlines
mié. 12/104:43 pmPTY - CLT
2 stops13h 46mAmerican Airlines
Deal found 10/27$404

Cheap flight deals from South Carolina to Panama City

Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated octubre 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$352
(Avianca Connect)

One-way from

$152
(United Airlines)
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
Search Deals
From South Carolina to Panama City Tocumen Intl
Search Deals
One-way flight from South Carolina to Panama City Tocumen Intl
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Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 29, 2025.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

South Carolina

Fly to

Panama City

Route

Depart

Return

Price

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

sáb. 11/15

9:57 pm-8:50 am

2 stops10h 53m

Panama City Tocumen Intl

mar. 11/18

2:55 pm-1:00 pm

2 stops22h 05m

$352

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

jue. 12/11

8:10 pm-1:47 pm

1 stop17h 37m

Panama City Tocumen Intl

jue. 12/18

4:55 pm-8:47 am

1 stop15h 52m

$377

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

jue. 11/27

8:52 pm-2:00 pm

2 stops17h 08m

Panama City Tocumen Intl

mié. 12/3

2:55 am-7:10 pm

2 stops16h 15m

$382

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mar. 1/13

4:55 pm-7:38 pm

1 stop26h 43m

Panama City Tocumen Intl

lun. 1/19

4:41 pm-9:57 pm

1 stop29h 16m

$386

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

sáb. 3/14

7:25 pm-4:10 am

1 stop9h 45m

Panama City Tocumen Intl

mar. 3/17

10:55 pm-9:15 am

1 stop9h 20m

$390

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

sáb. 3/14

7:25 pm-4:10 am

1 stop9h 45m

Panama City Tocumen Intl

mar. 3/24

10:55 pm-9:15 am

1 stop9h 20m

$390

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 12/10

5:10 am-1:47 pm

1 stop8h 37m

Panama City Tocumen Intl

mar. 12/16

2:50 pm-11:59 pm

1 stop9h 09m

$392

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 1/21

7:00 am-1:27 pm

1 stop6h 27m

Panama City Tocumen Intl

mié. 2/4

2:27 pm-11:57 pm

1 stop9h 30m

$392

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

sáb. 3/14

6:31 pm-12:10 pm

2 stops18h 39m

Panama City Tocumen Intl

mar. 3/17

1:50 pm-10:59 am

2 stops20h 09m

$394

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 11/19

5:00 am-1:49 pm

1 stop8h 49m

Panama City Tocumen Intl

mié. 11/26

2:43 pm-11:59 pm

1 stop9h 16m

$398

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama City

What is the cheapest month to book a flight from South Carolina to Panama City?

Currently, November is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $228). Flying from South Carolina to Panama City in May is currently the most expensive (average of $419). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to PTY?

Find hourly flight availability from South Carolina to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 29, 2025.

It’s optimal to fly from South Carolina to Panama City in the afternoon. By choosing this option you can save up to 10% on the cost of your flight, compared to a flight at noon.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from South Carolina?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Panama City from South Carolina.

  • How long is the flight from South Carolina to Panama City?

    A quick flight from South Carolina to Panama City can take about 6h 15m. American Airlines provides one of the quickest options available for as low as $400. There are 1808 mi between South Carolina and Panama City. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Panama City one-way?

    The cheapest airlines for a one-way flight from South Carolina to Panama City are United Airlines ($152), Delta ($152), and American Airlines ($152).

  • What are the most popular routes from South Carolina to Panama City?

    The most popular route from South Carolina to Panama City is Charlotte Douglas - Panama City Tocumen Intl. You may also consider Charleston - Panama City Tocumen Intl or Columbia Metropolitan - Panama City Tocumen Intl.

  • Can I find deals for flights from South Carolina to Panama City that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama City.

  • Can I find deals for business class flights from South Carolina to Panama City?

    Yes. Cheapflights offers flight deals from South Carolina to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama City?

    Currently, November is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $228). Flying from South Carolina to Panama City in May is currently the most expensive (average of $419). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Panama City

Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$352Average$439FlexibilityNo cancel feeOn-time69%
DeltaCheapest$369Average$540FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$383Average$561FlexibilityNo cancel feeOn-time71%

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