$329+ Cheap flights from Greenville (GSP) to Panama City (PTY)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
Nov 27 — Dec 41
Round-trip
1 adult, Economy
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Find cheap flights from Greenville to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greenville to Panama City
Cheapest
Best
Last-minute
One-way
Cheapest flights from Greenville to Panama CityExplore the most affordable flight options available from Greenville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2026.
Explore the most affordable flight options available from Greenville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2026.
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/83:41 pm -
2 stops22h 32m
Tue 12/153:13 pm -
2 stops19h 53m
Deal found 10/24![American Airlines logo]()
$710
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:30 am -
1 stop8h 15m
Tue 12/158:55 am -
1 stop13h 04m
Deal found 10/24![United Airlines logo]()
$715
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/174:37 pm -
2 stops21h 36m
Tue 12/153:13 pm -
2 stops19h 16m
Deal found 10/25![American Airlines logo]()
$735
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:49 am -
1 stop12h 49m
Tue 12/1511:35 am -
1 stop10h 24m
Deal found 10/25![United Airlines logo]()
$740
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/104:54 pm -
2 stops21h 19m
Thu 12/174:33 pm -
1 stop8h 26m
Deal found 10/25![American Airlines logo]()
$752
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:20 am -
2 stops13h 42m
Mon 11/304:41 pm -
2 stops26h 32m
Deal found 10/26![United Airlines logo]()
$763
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:30 am -
1 stop10h 42m
Tue 12/1510:00 am -
1 stop13h 40m
Deal found 10/26![United Airlines logo]()
$765
This KAYAK deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:30 am -
2 stops13h 08m
Tue 12/1511:35 am -
1 stop10h 24m
Deal found 10/24![Copa Airlines logo]()
$769
Best flights from Greenville to Panama CityDiscover carefully curated flight deals from Greenville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 28, 2026.
Discover carefully curated flight deals from Greenville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 28, 2026.
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/187:00 am -
1 stop12h 38m
Mon 3/157:55 am -
1 stop12h 50m
Deal found 10/28![United Airlines logo]()
$685
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/45:50 am -
1 stop14h 12m
Thu 1/2110:00 am -
1 stop13h 34m
Deal found 10/27![United Airlines logo]()
$697
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/207:00 am -
1 stop12h 37m
Wed 4/2110:55 pm -
1 stop17h 24m
Deal found 10/25![United Airlines logo]()
$697
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/115:50 am -
1 stop14h 12m
Wed 1/2710:00 am -
1 stop13h 34m
Deal found 10/26![United Airlines logo]()
$697
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/126:30 am -
1 stop10h 42m
Thu 1/288:55 am -
1 stop13h 04m
Deal found 10/25![United Airlines logo]()
$697
Last-minute flights from Greenville to Panama CityDiscover last-minute flight deals from Greenville to Panama City. Data last updated October 28, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to Panama City. Data last updated October 28, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/155:17 pm -
2 stops20h 56m
Sun 11/293:34 pm -
2 stops19h 04m
Deal found 10/26![American Airlines logo]()
$1,031
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/174:37 pm -
2 stops21h 36m
Tue 12/153:13 pm -
2 stops19h 16m
Deal found 10/25![American Airlines logo]()
$735
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:49 am -
1 stop12h 49m
Tue 12/1511:35 am -
1 stop10h 24m
Deal found 10/25![United Airlines logo]()
$740
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:20 am -
2 stops13h 42m
Mon 11/304:41 pm -
2 stops26h 32m
Deal found 10/26![United Airlines logo]()
$763
This BusinessClass deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:49 am -
1 stop7h 56m
Sat 12/510:00 am -
1 stop13h 40m
Deal found 10/28![Copa Airlines logo]()
$1,821
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:49 am -
1 stop7h 56m
Sat 12/510:00 am -
1 stop13h 40m
Deal found 10/28![United Airlines logo]()
$1,847
This Travelocity deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/305:37 pm -
2 stops23h 38m
Sat 12/56:10 pm -
2 stops50h 49m
Deal found 10/28![Avianca logo]()
$4,283
One-way flights from Greenville to Panama CitySearch for one-way flight options from Greenville to Panama City. Find affordable one-way fares based on user searches. Data last updated October 28, 2026.
Search for one-way flight options from Greenville to Panama City. Find affordable one-way fares based on user searches. Data last updated October 28, 2026.
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:43 pm -
2 stops24h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![United Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:35 pm -
2 stops17h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![American Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:20 am -
2 stops13h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![United Airlines logo]()
$375
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:43 pm -
2 stops24h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![United Airlines logo]()
$380
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:20 am -
2 stops13h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![United Airlines logo]()
$385
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/173:26 pm -
2 stops22h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![American Airlines logo]()
$390
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/228:44 am -
3 stops40h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Multiple Airlines logo]()
$451
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:41 pm -
2 stops18h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![American Airlines logo]()
$530
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:50 pm -
3 stops22h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$1,294
Find flight deals from Greenville to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $665 (United Airlines) |
One-way from | $339 (American Airlines) |
Popular in | December |
Cheapest in | November |
Average price | $836 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 28, 2026.
Use the filters below to find and compare flights from Greenville to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Wed 11/25
7:43 pm-8:02 pm
2 stops24h 19m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$329
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Wed 11/25
8:35 pm-2:34 pm
2 stops17h 59m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$339
Quickest round-trip
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Tue 11/17
6:49 am-2:45 pm
1 stop7h 56m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$375
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Wed 11/11
5:40 am-8:02 pm
1 stop14h 22m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$385
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Wed 11/18
6:20 am-8:02 pm
2 stops13h 42m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$385
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Tue 11/17
3:26 pm-2:13 pm
2 stops22h 47m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$390
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Sun 11/22
5:12 pm-7:38 pm
1 stop26h 26m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$394
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Thu 2/18
7:00 am-7:38 pm
1 stop12h 38m
Panama City Tocumen Intl
Mon 3/15
7:55 am-9:45 pm
1 stop12h 50m
$685
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Mon 1/4
5:50 am-8:02 pm
1 stop14h 12m
Panama City Tocumen Intl
Thu 1/21
10:00 am-11:34 pm
1 stop13h 34m
$697
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Tue 4/20
7:00 am-6:37 pm
1 stop12h 37m
Panama City Tocumen Intl
Wed 4/21
10:55 pm-5:19 pm
1 stop17h 24m
$697
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Greenville to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Panama City in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greenville-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Greenville with our price prediction graph.
GSP-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to Panama City
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated October 28, 2026.
Read reviews from past customers who have flown American Airlines from Greenville to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Entertainment
6.8
Overall
7.0
Boarding
7.4
Food
6.4
Comfort
7.1
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Crew
7.9
Entertainment
6.8
Overall
7.0
Boarding
7.4
Food
6.4
Comfort
7.1
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Greenville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Greenville to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Greenville and Panama City flights
Browse other Greenville and Panama City flight options. Last updated on October 28, 2026.
Other flights from Greenville
Browse through other flights departing from Greenville. Flights are based on user searches made on Cheapflights and were last updated on October 28, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Greenville to Panama City
Discover the top airline that operate flights from Greenville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$543 | Average$747 | FlexibilityNo cancel fee | On-time71% |