HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$497+ Cheap flights from Greenville (GSP) to Panama City (PTY)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/6. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
Μαϊ 29 — Ιουν 51
Παρ 5/29
Παρ 6/5
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Greenville to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Greenville to Panama City

Cheapest flights from Greenville to Panama City
Explore the most affordable flight options available from Greenville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on Απρίλιος 29, 2026.

This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Δευ 7/67:49 pm
GSP
-
PTY
1 stop9h 15m
United Airlines
Δευ 7/1310:55 pm
PTY
-
GSP
1 stop10h 42m
United Airlines
Deal found 4/28$497
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Τρι 9/156:30 am
GSP
-
PTY
2 stops14h 01m
United Airlines
Πεμ 10/159:45 am
PTY
-
GSP
1 stop12h 44m
United Airlines
Deal found 4/28$501
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Σαβ 6/206:49 am
GSP
-
PTY
1 stop7h 10m
Delta
Τετ 6/242:24 pm
PTY
-
GSP
1 stop19h 35m
Delta
Deal found 4/25$534
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Παρ 6/1911:44 am
GSP
-
PTY
1 stop26h 15m
Delta
Τετ 6/242:24 pm
PTY
-
GSP
1 stop17h 54m
Delta
Deal found 4/25$541
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Παρ 7/317:32 pm
GSP
-
PTY
2 stops17h 42m
American Airlines
Παρ 8/141:24 pm
PTY
-
GSP
2 stops20h 37m
American Airlines
Deal found 4/28$545
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Πεμ 6/116:30 am
GSP
-
PTY
1 stop14h 01m
United Airlines
Πεμ 6/183:30 pm
PTY
-
GSP
2 stops24h 30m
United Airlines
Deal found 4/27$549
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Πεμ 5/77:00 am
GSP
-
PTY
1 stop10h 12m
United Airlines
Δευ 5/119:45 am
PTY
-
GSP
1 stop12h 20m
United Airlines
Deal found 4/28$555
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Τρι 4/286:00 am
GSP
-
PTY
1 stop14h 31m
United Airlines
Δευ 5/43:30 pm
PTY
-
GSP
2 stops17h 27m
United Airlines
Deal found 4/27$559
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Κυρ 8/96:05 pm
GSP
-
PTY
2 stops19h 19m
American Airlines
Σαβ 8/151:24 pm
PTY
-
GSP
2 stops20h 37m
American Airlines
Deal found 4/28$563

Find flight deals from Greenville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated Απρίλιος 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$497
(United Airlines)

Popular in

December

Cheapest in

August

Average price

$667
Provider with most accurate pricing for Greenville-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Panama City Tocumen Intl flights.
Search Deals
From Greenville to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($226 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 14% potential price decrease ($78 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Απρίλιος 29, 2026.
Use the filters below to find and compare flights from Greenville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Δευ 7/6

7:49 pm-4:04 am

1 stop9h 15m

Panama City Tocumen Intl

Δευ 7/13

10:55 pm-10:37 am

1 stop10h 42m

$497

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Σαβ 6/20

6:49 am-12:59 pm

1 stop7h 10m

Panama City Tocumen Intl

Τετ 6/24

2:24 pm-10:59 am

1 stop19h 35m

$534

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Παρ 6/19

11:44 am-12:59 pm

1 stop26h 15m

Panama City Tocumen Intl

Τετ 6/24

2:24 pm-9:18 am

1 stop17h 54m

$541

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Τετ 6/10

11:18 am-7:31 pm

1 stop9h 13m

Panama City Tocumen Intl

Τετ 6/17

9:45 am-11:29 pm

1 stop12h 44m

$608

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Τετ 6/24

5:41 pm-2:14 pm

2 stops21h 33m

Panama City Tocumen Intl

Τετ 7/29

9:45 am-2:20 pm

2 stops27h 35m

$613

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Πεμ 6/11

8:15 pm-12:13 pm

1 stop16h 58m

Panama City Tocumen Intl

Τρι 6/16

1:15 pm-10:08 am

2 stops19h 53m

$614

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Τετ 6/17

8:15 pm-12:14 pm

1 stop16h 59m

Panama City Tocumen Intl

Τετ 6/24

1:14 pm-12:24 pm

2 stops22h 10m

$614

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Sorted by cheapest first

Compare providers for flights from Greenville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Panama City in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Panama City

How much does it cost to fly round-trip from Greenville to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated Απρίλιος 29, 2026.
Read reviews from past customers who have flown Delta from Greenville to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,467 reviews

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Overall

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,467 reviews
Delta
7.9
Good
8,467 reviews

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Overall

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Panama City?

    United Airlines and Delta can get you from Greenville to Panama City in just under 7h 10m. Your travel time can differ by up to 2h 05m. Greenville and Panama City are separated by a distance of 1792 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Greenville to Panama City round-trip?

    Flying on Delta is currently your cheapest option to Panama City, with prices starting at $183. Delta is priced at 70% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Greenville to Panama City that include hotel bookings?

    Yes. In addition to deals on Greenville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Panama City.

  • Can I find deals for business class flights from Greenville to Panama City?

    Yes. Cheapflights offers flight deals from Greenville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Greenville to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to Panama City flights
Columbia to Panama City flights
Charleston to Panama City flights
Savannah to Panama City flights
Augusta to Panama City flights
Myrtle Beach to Panama City flights

Top airline flying from Greenville to Panama City

Discover the top airline that operate flights from Greenville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Απρίλιος 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$183Average$424FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.