$641+ Cheap flights from Greenville (GSP) to Panama City (PTY)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
Oct 10 — Oct 171
Round-trip
1 adult, Economy
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Find cheap flights from Greenville to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greenville to Panama City
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Best
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Cheapest flights from Greenville to Panama CityExplore the most affordable flight options available from Greenville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from Greenville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:05 am -
1 stop5h 54m
Thu 11/123:29 pm -
1 stop8h 24m
Deal found 9/10![Delta logo]()
$655
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:35 pm -
2 stops24h 56m
Thu 11/1210:00 am -
1 stop13h 00m
Deal found 9/10![United Airlines logo]()
$659
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2211:30 am -
1 stop9h 01m
Thu 10/293:41 pm -
1 stop23h 47m
Deal found 9/7![United Airlines logo]()
$666
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:00 am -
1 stop14h 31m
Thu 10/229:45 am -
1 stop12h 28m
Deal found 9/6![United Airlines logo]()
$673
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:21 pm -
2 stops19h 41m
Thu 10/222:02 pm -
2 stops17h 22m
Deal found 9/6![American Airlines logo]()
$677
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:49 am -
1 stop7h 56m
Tue 11/1710:00 am -
1 stop13h 47m
Deal found 9/7![United Airlines logo]()
$690
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:33 pm -
2 stops17h 29m
Fri 10/302:02 pm -
2 stops20h 06m
Deal found 9/8![American Airlines logo]()
$702
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1511:30 am -
1 stop9h 01m
Thu 10/159:45 am -
1 stop12h 28m
Deal found 9/7![United Airlines logo]()
$711
Best flights from Greenville to Panama CityDiscover carefully curated flight deals from Greenville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from Greenville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/186:30 am -
2 stops13h 32m
Mon 3/159:30 am -
1 stop12h 49m
Deal found 9/9![United Airlines logo]()
$641
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:05 am -
1 stop5h 54m
Thu 11/123:29 pm -
1 stop8h 24m
Deal found 9/10![Delta logo]()
$655
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
1 stop8h 02m
Fri 10/302:02 pm -
2 stops25h 33m
Deal found 9/8![American Airlines logo]()
$659
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:35 pm -
2 stops24h 56m
Thu 11/1210:00 am -
1 stop13h 00m
Deal found 9/10![United Airlines logo]()
$659
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:00 am -
1 stop8h 02m
Fri 10/232:02 pm -
1 stop7h 50m
Deal found 9/6![American Airlines logo]()
$673
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:00 am -
1 stop14h 31m
Thu 10/293:41 pm -
2 stops24h 15m
Deal found 9/7![United Airlines logo]()
$678
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/187:29 pm -
1 stop19h 45m
Mon 3/151:44 pm -
1 stop9h 15m
Deal found 9/9![American Airlines logo]()
$705
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:00 am -
1 stop8h 02m
Mon 10/122:02 pm -
1 stop7h 50m
Deal found 9/8![American Airlines logo]()
$716
Last-minute flights from Greenville to Panama CityDiscover last-minute flight deals from Greenville to Panama City. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to Panama City. Data last updated September 10, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1511:30 am -
1 stop9h 01m
Thu 10/159:45 am -
1 stop12h 28m
Deal found 9/7![United Airlines logo]()
$711
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:00 am -
1 stop8h 02m
Mon 10/122:02 pm -
1 stop7h 50m
Deal found 9/6![American Airlines logo]()
$716
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:00 am -
1 stop14h 31m
Thu 10/229:45 am -
1 stop12h 28m
Deal found 9/6![United Airlines logo]()
$673
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:21 pm -
2 stops19h 41m
Thu 10/222:02 pm -
2 stops17h 22m
Deal found 9/6![American Airlines logo]()
$677
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:05 am -
1 stop5h 54m
Thu 11/123:29 pm -
1 stop8h 24m
Deal found 9/10![Delta logo]()
$655
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:35 pm -
2 stops24h 56m
Thu 11/1210:00 am -
1 stop13h 00m
Deal found 9/10![United Airlines logo]()
$659
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2211:30 am -
1 stop9h 01m
Thu 10/293:41 pm -
1 stop23h 47m
Deal found 9/7![United Airlines logo]()
$666
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:33 pm -
2 stops17h 29m
Fri 10/302:02 pm -
2 stops20h 06m
Deal found 9/8![American Airlines logo]()
$702
One-way flights from Greenville to Panama CitySearch for one-way flight options from Greenville to Panama City. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
Search for one-way flight options from Greenville to Panama City. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/285:40 am -
1 stop8h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Delta logo]()
$687
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/295:40 am -
1 stop8h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Delta logo]()
$943
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/285:40 am -
3 stops56h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$1,062
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/305:40 am -
1 stop8h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Delta logo]()
$1,196
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/295:40 am -
3 stops56h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$1,308
This WestJet deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure WestJet is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/285:40 am -
2 stops26h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![WestJet logo]()
$4,353
This WestJet deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure WestJet is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:05 am -
2 stops25h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![WestJet logo]()
$4,918
Find flight deals from Greenville to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $637 (American Airlines) |
Popular in | December |
Cheapest in | February |
Average price | $764 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from Greenville to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Thu 2/18
6:30 am-8:02 pm
2 stops13h 32m
Panama City Tocumen Intl
Mon 3/15
9:30 am-11:19 pm
1 stop12h 49m
$641
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Tue 10/20
8:05 am-12:59 pm
1 stop5h 54m
Panama City Tocumen Intl
Thu 11/12
3:29 pm-11:53 pm
1 stop8h 24m
$655
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Fri 10/23
6:00 am-1:02 pm
1 stop8h 02m
Panama City Tocumen Intl
Fri 10/30
2:02 pm-4:35 pm
2 stops25h 33m
$659
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Tue 10/20
7:35 pm-7:31 pm
2 stops24h 56m
Panama City Tocumen Intl
Thu 11/12
10:00 am-11:00 pm
1 stop13h 00m
$659
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Tue 10/20
6:00 am-1:02 pm
1 stop8h 02m
Panama City Tocumen Intl
Fri 10/23
2:02 pm-10:52 pm
1 stop7h 50m
$673
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Thu 10/22
6:00 am-7:31 pm
1 stop14h 31m
Panama City Tocumen Intl
Thu 10/29
3:41 pm-4:56 pm
2 stops24h 15m
$678
Quickest round-trip
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Sat 11/28
5:40 am-2:02 pm
1 stop8h 22m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$687
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Thu 2/18
7:29 pm-3:14 pm
1 stop19h 45m
Panama City Tocumen Intl
Mon 3/15
1:44 pm-11:59 pm
1 stop9h 15m
$705
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Tue 10/6
6:00 am-1:02 pm
1 stop8h 02m
Panama City Tocumen Intl
Mon 10/12
2:02 pm-10:52 pm
1 stop7h 50m
$716
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Sun 11/29
5:40 am-2:02 pm
1 stop8h 22m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$943
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Greenville to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Panama City in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greenville-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Greenville with our price prediction graph.
GSP-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to Panama City
What is the cheapest month to book a flight from Greenville to Panama City?
Currently, February is the cheapest month in which you can book a flight from Greenville to Panama City (average of $485). Flying from Greenville to Panama City in December is currently the most expensive (average of $1,387). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Greenville to Panama City?
Airfare is below average for this route at the moment.
Greenville to Panama City flights typically cost between $758 and $813 in January.The cheapest round-trip price found within the last 5 days was $637 on American Airlines (Jan 5-Feb 5).
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 10, 2026.
Read reviews from past customers who have flown American Airlines from Greenville to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.4
Crew
7.9
Overall
7.1
Boarding
7.5
Comfort
7.2
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Food
6.4
Crew
7.9
Overall
7.1
Boarding
7.5
Comfort
7.2
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Greenville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
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Find flights from Greenville to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Greenville and Panama City flights
Browse other Greenville and Panama City flight options. Last updated on September 10, 2026.
Other flights from Greenville
Browse through other flights departing from Greenville. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Greenville to Panama City
Discover the top airline that operate flights from Greenville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$495 | Average$745 | FlexibilityNo cancel fee | On-time71% |