$329+ Cheap flights from Greenville (GSP) to Panama
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
Nov 28 — Dec 51
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
Last-minute
One-way
Cheapest flights from Greenville to PanamaExplore the most affordable flight options available from Greenville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2026.
Explore the most affordable flight options available from Greenville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2026.
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/83:41 pm -
2 stops22h 32m
Tue 12/153:13 pm -
2 stops19h 53m
Deal found 10/24![American Airlines logo]()
$710
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:30 am -
1 stop8h 15m
Tue 12/158:55 am -
1 stop13h 04m
Deal found 10/24![United Airlines logo]()
$715
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/174:37 pm -
2 stops21h 36m
Tue 12/153:13 pm -
2 stops19h 16m
Deal found 10/25![American Airlines logo]()
$735
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:49 am -
1 stop12h 49m
Tue 12/1511:35 am -
1 stop10h 24m
Deal found 10/25![United Airlines logo]()
$740
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:31 pm -
2 stops17h 42m
Thu 12/174:33 pm -
2 stops19h 10m
Deal found 10/25![American Airlines logo]()
$752
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:20 am -
2 stops13h 42m
Mon 11/304:41 pm -
2 stops26h 32m
Deal found 10/26![United Airlines logo]()
$763
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:30 am -
1 stop10h 42m
Tue 12/1510:00 am -
1 stop13h 40m
Deal found 10/26![United Airlines logo]()
$765
This KAYAK deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:30 am -
2 stops13h 08m
Tue 12/1511:35 am -
1 stop10h 24m
Deal found 10/24![Copa Airlines logo]()
$769
Best flights from Greenville to PanamaDiscover carefully curated flight deals from Greenville to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 29, 2026.
Discover carefully curated flight deals from Greenville to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 29, 2026.
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/187:00 am -
1 stop12h 38m
Mon 3/157:55 am -
1 stop12h 50m
Deal found 10/28![United Airlines logo]()
$685
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/45:50 am -
1 stop14h 12m
Thu 1/2110:00 am -
1 stop13h 34m
Deal found 10/27![United Airlines logo]()
$697
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/207:00 am -
1 stop12h 37m
Wed 4/2110:55 pm -
1 stop17h 24m
Deal found 10/25![United Airlines logo]()
$697
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/115:50 am -
1 stop14h 12m
Wed 1/2710:00 am -
1 stop13h 34m
Deal found 10/26![United Airlines logo]()
$697
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/126:30 am -
1 stop10h 42m
Thu 1/288:55 am -
1 stop13h 04m
Deal found 10/25![United Airlines logo]()
$697
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/196:30 am -
2 stops13h 32m
Tue 1/264:41 pm -
2 stops26h 26m
Deal found 10/28![United Airlines logo]()
$702
Last-minute flights from Greenville to PanamaDiscover last-minute flight deals from Greenville to Panama. Data last updated October 29, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to Panama. Data last updated October 29, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:20 am -
2 stops13h 18m
Mon 11/164:41 pm -
2 stops17h 10m
Deal found 10/28![United Airlines logo]()
$842
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:40 am -
1 stop8h 22m
Mon 11/163:29 pm -
1 stop6h 43m
Deal found 10/28![Delta logo]()
$885
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:20 am -
2 stops13h 18m
Sun 11/154:41 pm -
2 stops16h 49m
Deal found 10/28![United Airlines logo]()
$899
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:20 am -
2 stops13h 18m
Sat 11/144:41 pm -
2 stops16h 49m
Deal found 10/28![United Airlines logo]()
$940
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:40 am -
1 stop14h 22m
Mon 11/1610:00 am -
1 stop13h 47m
Deal found 10/28![United Airlines logo]()
$872
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:40 am -
1 stop14h 22m
Sun 11/1510:00 am -
1 stop13h 47m
Deal found 10/28![United Airlines logo]()
$929
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/174:37 pm -
2 stops21h 36m
Tue 12/153:13 pm -
2 stops19h 16m
Deal found 10/25![American Airlines logo]()
$735
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:49 am -
1 stop12h 49m
Tue 12/1511:35 am -
1 stop10h 24m
Deal found 10/25![United Airlines logo]()
$740
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:20 am -
2 stops13h 42m
Mon 11/304:41 pm -
2 stops26h 32m
Deal found 10/26![United Airlines logo]()
$763
One-way flights from Greenville to PanamaSearch for one-way flight options from Greenville to Panama. Find affordable one-way fares based on user searches. Data last updated October 29, 2026.
Search for one-way flight options from Greenville to Panama. Find affordable one-way fares based on user searches. Data last updated October 29, 2026.
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:43 pm -
2 stops24h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![United Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:35 pm -
2 stops17h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![American Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:20 am -
2 stops13h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![United Airlines logo]()
$375
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:43 pm -
2 stops24h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![United Airlines logo]()
$380
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:20 am -
2 stops13h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![United Airlines logo]()
$385
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/173:26 pm -
2 stops22h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![American Airlines logo]()
$390
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/228:44 am -
3 stops40h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Multiple Airlines logo]()
$451
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:41 pm -
2 stops18h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![American Airlines logo]()
$530
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:50 pm -
3 stops22h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$1,294
Find flight deals from Greenville to Panama
Keep the following information in mind while searching for Greenville to Panama flight deals. Data was last updated October 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $685 (United Airlines) |
One-way from | $329 (United Airlines) |
Popular in | December |
Cheapest in | November |
Average price | $836 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 29, 2026.
Use the filters below to find and compare flights from Greenville to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Wed 11/25
7:43 pm-8:02 pm
2 stops24h 19m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$329
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Wed 11/25
8:35 pm-2:34 pm
2 stops17h 59m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$339
Quickest round-trip
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Tue 11/17
6:49 am-2:45 pm
1 stop7h 56m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$375
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Wed 11/11
5:40 am-8:02 pm
1 stop14h 22m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$385
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Wed 11/18
6:20 am-8:02 pm
2 stops13h 42m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$385
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Tue 11/17
3:26 pm-2:13 pm
2 stops22h 47m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$390
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Sun 11/22
5:12 pm-7:38 pm
1 stop26h 26m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$394
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Thu 2/18
7:00 am-7:38 pm
1 stop12h 38m
Panama City Tocumen Intl
Mon 3/15
7:55 am-9:45 pm
1 stop12h 50m
$685
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Mon 1/4
5:50 am-8:02 pm
1 stop14h 12m
Panama City Tocumen Intl
Thu 1/21
10:00 am-11:34 pm
1 stop13h 34m
$697
GreenvillePanama City
GSP Greenville - PTY Panama City Tocumen Intl
GSPPTY
Greenville
Tue 4/20
7:00 am-6:37 pm
1 stop12h 37m
Panama City Tocumen Intl
Wed 4/21
10:55 pm-5:19 pm
1 stop17h 24m
$697
Showing 1-10 of 14 resultsSorted by cheapest first
Best time to book a flight from Greenville to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Greenville with our price prediction graph.
GSP-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to Panama
GSP-PA0
GSP-PTY
What is the cheapest month to book a flight from Greenville to Panama?
Currently, November is the cheapest month in which you can book a flight from Greenville to Panama (average of $452). Flying from Greenville to Panama in December is currently the most expensive (average of $1,387). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Panama
Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated October 29, 2026.
Read reviews from past customers who have flown American Airlines from Greenville to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.1
Overall
7.0
Boarding
7.4
Crew
7.9
Entertainment
6.8
Food
6.4
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Comfort
7.1
Overall
7.0
Boarding
7.4
Crew
7.9
Entertainment
6.8
Food
6.4
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Greenville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Panama by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Greenville to Panama, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Greenville and Panama flights
Browse other Greenville and Panama flight options. Last updated on October 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Greenville to Panama
Discover the top airline that operate flights from Greenville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$543 | Average$747 | FlexibilityNo cancel fee | On-time71% |