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$264+ Cheap flights from Greenville (GSP) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/24. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
Aug 29 — Sep 51
Sat 8/29
Sat 9/5
1 adult, Economy
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Cheap flight deals from Greenville to Panama

Cheapest flights from Greenville to Panama
Explore the most affordable flight options available from Greenville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2026.

This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:00 am
GSP
-
PTY
1 stop13h 31m
United Airlines
Wed 9/309:45 am
PTY
-
GSP
1 stop12h 28m
United Airlines
Deal found 7/28$587
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2410:04 am
GSP
-
PTY
1 stop27h 51m
Delta
Wed 8/262:20 pm
PTY
-
GSP
1 stop19h 20m
Delta
Deal found 7/27$594
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:00 am
GSP
-
PTY
1 stop13h 31m
United Airlines
Wed 9/169:45 am
PTY
-
GSP
1 stop12h 30m
United Airlines
Deal found 7/25$595
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:00 am
GSP
-
PTY
1 stop13h 31m
United Airlines
Thu 10/153:30 pm
PTY
-
GSP
1 stop29h 28m
United Airlines
Deal found 7/25$597
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:00 am
GSP
-
PTY
1 stop13h 31m
United Airlines
Wed 9/29:45 am
PTY
-
GSP
1 stop12h 18m
United Airlines
Deal found 7/26$603
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:45 am
GSP
-
PTY
1 stop8h 00m
United Airlines
Tue 11/310:00 am
PTY
-
GSP
1 stop13h 47m
United Airlines
Deal found 7/26$613
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:00 am
GSP
-
PTY
1 stop6h 58m
Delta
Thu 10/152:24 pm
PTY
-
GSP
1 stop7h 27m
Delta
Deal found 7/29$615

Find flight deals from Greenville to Panama

Keep the following information in mind while searching for Greenville to Panama flight deals. Data was last updated July 30, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$587
(United Airlines)

One-way from

$264
(United Airlines)

Popular in

December

Cheapest in

September

Average price

$695
Provider with most accurate pricing for Greenville-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Panama City Tocumen Intl flights.
Search Deals
From Greenville to Panama
Search Deals
One-way flight from Greenville to Panama
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($160 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($65 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
Use the filters below to find and compare flights from Greenville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 9/15

7:00 am-12:58 pm

1 stop6h 58m

Panama City Tocumen Intl

Thu 10/15

2:24 pm-10:51 pm

1 stop7h 27m

$587

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 9/23

7:00 am-7:31 pm

1 stop13h 31m

Panama City Tocumen Intl

Wed 9/30

9:45 am-11:13 pm

1 stop12h 28m

$587

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 9/23

7:00 am-12:58 pm

1 stop6h 58m

Panama City Tocumen Intl

Wed 9/30

2:23 pm-10:55 pm

1 stop7h 32m

$587

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 9/15

6:30 am-6:37 pm

2 stops13h 07m

Panama City Tocumen Intl

Thu 10/15

9:45 am-9:58 am

2 stops23h 13m

$591

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 9/9

6:20 am-7:31 pm

2 stops14h 11m

Panama City Tocumen Intl

Wed 9/16

10:00 am-9:58 pm

1 stop10h 58m

$599

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 1/5

5:00 am-1:53 pm

1 stop8h 53m

Panama City Tocumen Intl

Fri 2/5

2:27 pm-11:57 pm

1 stop9h 30m

$603
Cheapest one-way

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 8/26

10:25 am-7:31 pm

2 stops10h 06m

$264

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 8/24

11:25 am-4:04 am

1 stop17h 39m

$264
Quickest one-way

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 8/25

6:55 am-12:55 pm

1 stop7h 00m

$269

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 8/25

10:25 am-4:04 am

2 stops18h 39m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Showing 1-10 of 12 resultsSorted by cheapest first
1
2

Best time to book a flight from Greenville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Panama

What is the cheapest month to book a flight from Greenville to Panama?

Currently, September is the cheapest month in which you can book a flight from Greenville to Panama (average of $235). Flying from Greenville to Panama in December is currently the most expensive (average of $1,387). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated July 30, 2026.
Read reviews from past customers who have flown American Airlines from Greenville to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,848 reviews

Overall

7.1

Boarding

7.5

Comfort

7.2

Entertainment

6.8

Crew

7.9

Food

6.4

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go
American Airlines
7.1
Good
11,848 reviews
American Airlines
7.1
Good
11,848 reviews

Overall

7.1

Boarding

7.5

Comfort

7.2

Entertainment

6.8

Crew

7.9

Food

6.4

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go

Related info for your journey

Find useful and relevant information for your journey from Greenville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Panama?

    Greenville (GSP), located 10.4 mi from the city center, is the airport you fly out of when you book flights from Greenville to Panama.

  • How long is the flight from Greenville to Panama?

    There are many flights that can get you from Greenville to Panama in 6h 58m. Fly via United Airlines or Delta to get the fastest option. Airlines will cover a distance of 1792 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Greenville to Panama that include hotel bookings?

    Yes. In addition to deals on Greenville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Panama.

  • Can I find deals for business class flights from Greenville to Panama?

    Yes. Cheapflights offers flight deals from Greenville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Panama?

    Currently, September is the cheapest month in which you can book a flight from Greenville to Panama (average of $235). Flying from Greenville to Panama in December is currently the most expensive (average of $1,387). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top airline flying from Greenville to Panama

Discover the top airline that operate flights from Greenville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$495Average$664FlexibilityNo cancel feeOn-time71%

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