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$246+ Cheap flights from Greenville (GSP) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
Jul 13 — Jul 201
Mon 7/13
Mon 7/20
1 adult, Economy
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Cheap flight deals from Greenville to Panama

Cheapest flights from Greenville to Panama
Explore the most affordable flight options available from Greenville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2026.

This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:46 am
GSP
-
PTY
1 stop8h 09m
Delta
Wed 8/192:20 pm
PTY
-
GSP
1 stop7h 39m
Delta
Deal found 6/8$557
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:00 am
GSP
-
PTY
1 stop8h 14m
United Airlines
Wed 8/1910:55 pm
PTY
-
GSP
2 stops13h 37m
United Airlines
Deal found 6/8$561
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:49 pm
GSP
-
PTY
1 stop9h 15m
United Airlines
Wed 7/297:55 am
PTY
-
GSP
1 stop14h 24m
United Airlines
Deal found 6/8$565
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:00 am
GSP
-
PTY
1 stop13h 31m
United Airlines
Thu 10/153:30 pm
PTY
-
GSP
1 stop29h 28m
United Airlines
Deal found 6/11$567
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/197:44 pm
GSP
-
PTY
1 stop18h 21m
Delta
Tue 7/282:24 pm
PTY
-
GSP
1 stop7h 31m
Delta
Deal found 6/8$571
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1511:18 am
GSP
-
PTY
1 stop17h 46m
United Airlines
Thu 7/2310:55 pm
PTY
-
GSP
1 stop10h 42m
United Airlines
Deal found 6/8$573
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:41 pm
GSP
-
PTY
2 stops17h 43m
American Airlines
Thu 10/153:35 pm
PTY
-
GSP
2 stops20h 20m
American Airlines
Deal found 6/10$577
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/197:44 pm
GSP
-
PTY
1 stop18h 21m
Delta
Wed 7/292:24 pm
PTY
-
GSP
1 stop19h 33m
Delta
Deal found 6/8$578
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/197:44 pm
GSP
-
PTY
1 stop18h 21m
Delta
Thu 7/232:24 pm
PTY
-
GSP
1 stop6h 51m
Delta
Deal found 6/8$579
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:49 pm
GSP
-
PTY
1 stop24h 42m
United Airlines
Mon 7/1310:55 pm
PTY
-
GSP
1 stop10h 42m
United Airlines
Deal found 6/8$581
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/177:49 pm
GSP
-
PTY
1 stop9h 15m
United Airlines
Tue 7/287:55 am
PTY
-
GSP
1 stop14h 24m
United Airlines
Deal found 6/8$583

Find flight deals from Greenville to Panama

Keep the following information in mind while searching for Greenville to Panama flight deals. Data was last updated June 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$557
(Delta)

One-way from

$246
(United Airlines)

Popular in

December

Cheapest in

July

Average price

$648
Provider with most accurate pricing for Greenville-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Panama City Tocumen Intl flights.
Search Deals
From Greenville to Panama
Search Deals
One-way flight from Greenville to Panama
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($182 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 12% potential price decrease ($73 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2026.
Use the filters below to find and compare flights from Greenville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Thu 7/30

7:49 pm-4:04 am

1 stop9h 15m

Panama City Tocumen Intl

Mon 8/3

10:55 pm-10:37 am

1 stop10h 42m

$557

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 8/11

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Wed 8/19

3:30 pm-1:32 pm

2 stops21h 02m

$561

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 7/15

7:49 pm-4:04 am

1 stop9h 15m

Panama City Tocumen Intl

Wed 7/29

7:55 am-11:19 pm

1 stop14h 24m

$565

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 7/27

7:40 pm-2:14 pm

2 stops19h 34m

Panama City Tocumen Intl

Mon 8/3

7:55 am-9:55 am

2 stops25h 00m

$569

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 7/21

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Tue 7/28

10:55 pm-9:26 pm

2 stops21h 31m

$569

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 7/20

7:40 pm-4:12 pm

2 stops21h 32m

Panama City Tocumen Intl

Mon 7/27

7:55 am-11:19 pm

1 stop14h 24m

$577

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 7/6

7:49 pm-7:31 pm

1 stop24h 42m

Panama City Tocumen Intl

Mon 7/13

10:55 pm-10:37 am

1 stop10h 42m

$581
Cheapest one-way

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 9/15

6:30 am-7:31 pm

2 stops14h 01m

$246

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 8/5

6:55 am-12:55 pm

1 stop7h 00m

$246
Quickest one-way

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Sun 10/4

7:00 am-12:56 pm

1 stop6h 56m

$272

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/9

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

Best time to book a flight from Greenville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Panama
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated June 13, 2026.
Read reviews from past customers who have flown United Airlines and American Airlines from Greenville to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,815 reviews

Overall

7.4

Food

6.6

Comfort

7.3

Boarding

7.7

Entertainment

7.1

Crew

8.1

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.
United Airlines
7.4
Good
9,815 reviews
United Airlines
7.4
Good
9,815 reviews

Overall

7.4

Food

6.6

Comfort

7.3

Boarding

7.7

Entertainment

7.1

Crew

8.1

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.
American Airlines
7.1
Good
11,649 reviews
United Airlines
7.4
Good
9,815 reviews

Overall

7.4

Food

6.6

Comfort

7.3

Boarding

7.7

Entertainment

7.1

Crew

8.1

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Panama?

    Greenville (GSP), located 10.4 mi from the city center, is the airport you fly out of when you book flights from Greenville to Panama.

  • How long is the flight from Greenville to Panama?

    There are many flights that can get you from Greenville to Panama in 9h 15m. Fly via United Airlines to get the fastest option. Airlines will cover a distance of 1792 mi.

  • Can I find deals for flights from Greenville to Panama that include hotel bookings?

    Yes. In addition to deals on Greenville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Panama.

  • Can I find deals for business class flights from Greenville to Panama?

    Yes. Cheapflights offers flight deals from Greenville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 2 airlines flying from Greenville to Panama

Discover the top 2 airlines that operate flights from Greenville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$391Average$485FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$421Average$664FlexibilityNo cancel feeOn-time71%

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