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$497+ Cheap flights from Greenville (GSP) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — PTY
May 30 — Jun 61
Sat 5/30
Sat 6/6
1 adult, Economy
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Cheap flight deals from Greenville to Panama

Cheapest flights from Greenville to Panama
Explore the most affordable flight options available from Greenville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.

This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:49 pm
GSP
-
PTY
1 stop9h 15m
United Airlines
Mon 7/1310:55 pm
PTY
-
GSP
1 stop10h 42m
United Airlines
Deal found 4/28$497
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:30 am
GSP
-
PTY
2 stops14h 01m
United Airlines
Thu 10/159:45 am
PTY
-
GSP
1 stop12h 44m
United Airlines
Deal found 4/28$501
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:00 am
GSP
-
PTY
1 stop12h 37m
United Airlines
Tue 8/253:30 pm
PTY
-
GSP
1 stop29h 23m
United Airlines
Deal found 4/29$506
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:00 am
GSP
-
PTY
1 stop14h 31m
United Airlines
Wed 5/279:45 am
PTY
-
GSP
1 stop12h 44m
United Airlines
Deal found 4/29$539
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:32 pm
GSP
-
PTY
2 stops17h 42m
American Airlines
Fri 8/141:24 pm
PTY
-
GSP
2 stops20h 37m
American Airlines
Deal found 4/28$545
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:20 am
GSP
-
PTY
1 stop14h 11m
United Airlines
Wed 6/2410:00 am
PTY
-
GSP
2 stops23h 14m
United Airlines
Deal found 4/29$547
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:30 am
GSP
-
PTY
1 stop14h 01m
United Airlines
Thu 6/183:30 pm
PTY
-
GSP
2 stops24h 30m
United Airlines
Deal found 4/27$549
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:00 am
GSP
-
PTY
1 stop10h 12m
United Airlines
Mon 5/119:45 am
PTY
-
GSP
1 stop12h 20m
United Airlines
Deal found 4/28$555
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:00 am
GSP
-
PTY
1 stop14h 31m
United Airlines
Mon 5/43:30 pm
PTY
-
GSP
2 stops17h 27m
United Airlines
Deal found 4/27$559
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:05 pm
GSP
-
PTY
2 stops19h 19m
American Airlines
Sat 8/151:24 pm
PTY
-
GSP
2 stops20h 37m
American Airlines
Deal found 4/28$563

Find flight deals from Greenville to Panama

Keep the following information in mind while searching for Greenville to Panama flight deals. Data was last updated April 30, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$497
(United Airlines)

Popular in

December

Cheapest in

August

Average price

$667
Provider with most accurate pricing for Greenville-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Panama City Tocumen Intl flights.
Search Deals
From Greenville to Panama
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($226 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 14% potential price decrease ($78 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
Use the filters below to find and compare flights from Greenville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 9/15

5:55 am-2:10 pm

1 stop9h 15m

Panama City Tocumen Intl

Thu 10/15

3:35 pm-11:14 pm

1 stop6h 39m

$497

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 7/6

7:49 pm-4:04 am

1 stop9h 15m

Panama City Tocumen Intl

Mon 7/13

10:55 pm-10:37 am

1 stop10h 42m

$497

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 5/20

6:00 am-7:31 pm

1 stop14h 31m

Panama City Tocumen Intl

Wed 5/27

9:45 am-11:29 pm

1 stop12h 44m

$539

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 6/17

6:20 am-7:31 pm

1 stop14h 11m

Panama City Tocumen Intl

Wed 6/24

10:00 am-10:14 am

2 stops23h 14m

$547

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/25

Sorted by cheapest first

Best time to book a flight from Greenville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Panama
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated April 30, 2026.
Read reviews from past customers who have flown Delta from Greenville to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,464 reviews

Crew

8.5

Entertainment

7.8

Overall

7.9

Comfort

7.9

Food

7.2

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,464 reviews
Delta
7.9
Good
8,464 reviews

Crew

8.5

Entertainment

7.8

Overall

7.9

Comfort

7.9

Food

7.2

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to Panama?

    Greenville (GSP), located 10.4 mi from the city center, is the airport you fly out of when you book flights from Greenville to Panama.

  • How long is the flight from Greenville to Panama?

    There are many flights that can get you from Greenville to Panama in 9h 15m. Fly via American Airlines or United Airlines to get the fastest option. Airlines will cover a distance of 1792 mi.

  • Can I find deals for flights from Greenville to Panama that include hotel bookings?

    Yes. In addition to deals on Greenville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Panama.

  • Can I find deals for business class flights from Greenville to Panama?

    Yes. Cheapflights offers flight deals from Greenville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Greenville to Panama

Discover the top airline that operate flights from Greenville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$183Average$424FlexibilityNo cancel feeOn-timeN/A

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