What are the cheapest airlines flying from Myrtle Beach to Panama City round-trip?

Cheapflights users have booked flights from Myrtle Beach to Panama City round-trip from $492. Other airlines that can offer you cheap pricing are Delta, from $727, and United Airlines, from $1,039. Users have found that American Airlines is 21% cheaper than the other options available to this destination.

What is the cheapest day to fly from Myrtle Beach to Panama City?

Travelers seeking maximum savings on their Myrtle Beach to Panama City flight should consider departing on Wednesday mornings when fares are most often at their lowest. Thursday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What is the cheapest day to fly round-trip from Myrtle Beach to Panama City?

Wednesday flights are generally found to be more expensive for flights from Myrtle Beach to Panama City. This shouldn’t discourage you from searching, as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to Panama City.

What is the cheapest month to fly from Myrtle Beach to Panama City?

August is one of the best times of the year to fly to Panama City from Myrtle Beach. Prices for August average $625 per person but you can even find prices for as low as $457. The most expensive prices can be found in the month of February. Opting for a August flight can save you 24% on your journey compared to booking in February

What is the cheapest time of day to fly from MYR to PTY?

When flying from Myrtle Beach to Panama City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Can I find deals for flights from Myrtle Beach to Panama City that include hotel bookings?

Yes. In addition to deals on Myrtle Beach to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Myrtle Beach to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Panama City.

Can I find deals for business class flights from Myrtle Beach to Panama City?

Yes. Cheapflights offers flight deals from Myrtle Beach to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$492+ Flights from Myrtle Beach to Panama City

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Cheap flight deals from Myrtle Beach to Panama City

Round-trip from	$492 (American Airlines)
Popular in	February
Cheapest in	August
Average price	$631

From Myrtle Beach Intl to Panama City Tocumen Intl

Search Deals

Highest demand for flights based on searches. 7% potential increase in price ($49 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($16 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in July 2025

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Find flight deals from Myrtle Beach to Panama City

Cheapest flights from Myrtle Beach to Panama City
Explore the most affordable flight options available from Myrtle Beach to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 8, 2025.

Thu 8/218:20 pmMYR - PTY

2 stops19h 10mAmerican Airlines

Thu 8/283:30 pmPTY - MYR

2 stops16h 26mAmerican Airlines

Deal found 7/6

$492

Thu 8/216:50 amMYR - PTY

3 stops15h 20mMultiple Airlines

Thu 8/2810:05 pmPTY - MYR

2 stops21h 04mMultiple Airlines

Deal found 7/6

$557

Thu 8/216:00 amMYR - PTY

1 stop7h 50mDelta

Thu 8/282:05 pmPTY - MYR

1 stop8h 44mDelta

Deal found 7/6

$727

Sat 7/1910:23 amMYR - PTY

1 stop10h 08mUnited Airlines

Thu 7/2410:55 pmPTY - MYR

1 stop10h 01mUnited Airlines

Deal found 7/7

$1,039

Best flights from Myrtle Beach to Panama City
Discover carefully curated flight deals from Myrtle Beach to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 8, 2025.

Thu 8/218:20 pmMYR - PTY

2 stops19h 10mAmerican Airlines

Thu 8/283:30 pmPTY - MYR

2 stops16h 26mAmerican Airlines

Deal found 7/6

$492

Thu 8/216:50 amMYR - PTY

3 stops15h 20mMultiple Airlines

Thu 8/2810:05 pmPTY - MYR

2 stops21h 04mMultiple Airlines

Deal found 7/6

$557

Thu 8/216:00 amMYR - PTY

1 stop7h 50mDelta

Thu 8/282:05 pmPTY - MYR

1 stop8h 44mDelta

Deal found 7/6

$727

Sat 7/1910:23 amMYR - PTY

1 stop10h 08mUnited Airlines

Thu 7/2410:55 pmPTY - MYR

1 stop10h 01mUnited Airlines

Deal found 7/7

$1,039

Last-minute flights from Myrtle Beach to Panama City
Discover last-minute flight deals from Myrtle Beach to Panama City. Data last updated July 8, 2025 and is based on user searches.

Sat 7/1910:23 amMYR - PTY

1 stop10h 08mUnited Airlines

Thu 7/2410:55 pmPTY - MYR

1 stop10h 01mUnited Airlines

Deal found 7/7

$1,039

Thu 8/218:20 pmMYR - PTY

2 stops19h 10mAmerican Airlines

Thu 8/283:30 pmPTY - MYR

2 stops16h 26mAmerican Airlines

Deal found 7/6

$492

Thu 8/216:50 amMYR - PTY

3 stops15h 20mMultiple Airlines

Thu 8/2810:05 pmPTY - MYR

2 stops21h 04mMultiple Airlines

Deal found 7/6

$557

Thu 8/216:00 amMYR - PTY

1 stop7h 50mDelta

Thu 8/282:05 pmPTY - MYR

1 stop8h 44mDelta

Deal found 7/6

$727

One-way flights from Myrtle Beach to Panama City
Search for one-way flight options from Myrtle Beach to Panama City. Find affordable one-way fares based on user searches. Data last updated July 8, 2025.

Fri 7/1811:00 amMYR - PTY

1 stop9h 31mDelta

Deal found 7/6

$591

Cheapflights Fare Finder

Use the filters below to find and compare flights from Myrtle Beach to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 8/21

8:20 pm-2:30 pm

2 stops19h 10m

Panama City Tocumen Intl

Thu 8/28

3:30 pm-8:56 am

2 stops16h 26m

$492

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 8/21

6:50 am-9:10 pm

3 stops15h 20m

Panama City Tocumen Intl

Thu 8/28

10:05 pm-8:09 pm

2 stops21h 04m

$557

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 8/21

6:00 am-12:50 pm

1 stop7h 50m

Panama City Tocumen Intl

Thu 8/28

2:05 pm-11:49 pm

1 stop8h 44m

$727

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sat 7/19

10:23 am-7:31 pm

1 stop10h 08m

Panama City Tocumen Intl

Thu 7/24

10:55 pm-9:56 am

1 stop10h 01m

$1,039

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Fri 7/18

11:00 am-7:31 pm

1 stop9h 31m

$591

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/6

Best time to book a flight from Myrtle Beach to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Myrtle Beach with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Panama City

What is the cheapest month to book a flight from Myrtle Beach to Panama City?

Currently, October is the cheapest month in which you can book a flight from Myrtle Beach to Panama City (average of $478). Flying from Myrtle Beach to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Myrtle Beach to Panama City?

Reviews of airlines servicing Panama City

Read through reviews of airlines operating flights from Myrtle Beach to Panama City, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,962 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,962 reviews

Delta

8.0

Very good

7,962 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,844 reviews

Delta

8.0

Very good

7,962 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,962 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from Myrtle Beach to Panama City round-trip?
Cheapflights users have booked flights from Myrtle Beach to Panama City round-trip from $492. Other airlines that can offer you cheap pricing are Delta, from $727, and United Airlines, from $1,039. Users have found that American Airlines is 21% cheaper than the other options available to this destination.
Can I find deals for flights from Myrtle Beach to Panama City that include hotel bookings?
Yes. In addition to deals on Myrtle Beach to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Myrtle Beach to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Panama City.
Can I find deals for business class flights from Myrtle Beach to Panama City?
Yes. Cheapflights offers flight deals from Myrtle Beach to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Myrtle Beach to Panama City?
Currently, October is the cheapest month in which you can book a flight from Myrtle Beach to Panama City (average of $478). Flying from Myrtle Beach to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from Myrtle Beach to Panama City

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$437	Average$570	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$457	Average$617	FlexibilityNo cancel fee	On-timeN/A

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$492+ Cheap flights from Myrtle Beach (MYR) to Panama City (PTY)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/21. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Myrtle Beach to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Myrtle Beach to Panama City

Round-trip from

Popular in

Cheapest in

Average price

Find flight deals from Myrtle Beach to Panama City

Cheapest flights from Myrtle Beach to Panama CityExplore the most affordable flight options available from Myrtle Beach to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 8, 2025.

Explore the most affordable flight options available from Myrtle Beach to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 8, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Myrtle Beach to Panama City that are best for you.

Best time to book a flight from Myrtle Beach to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Myrtle Beach with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Panama City

What is the cheapest month to book a flight from Myrtle Beach to Panama City?

How much does it cost to fly round-trip from Myrtle Beach to Panama City?

Reviews of airlines servicing Panama City

Read through reviews of airlines operating flights from Myrtle Beach to Panama City, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Myrtle Beach to Panama City round-trip?

Can I find deals for flights from Myrtle Beach to Panama City that include hotel bookings?

How can I find direct flights from Myrtle Beach to Panama City?

Can I find deals for business class flights from Myrtle Beach to Panama City?

What is the cheapest month to book a flight from Myrtle Beach to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Myrtle Beach to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Myrtle Beach to Panama City

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Book with Flexibility

Travel Smart

Cheapest flights from Myrtle Beach to Panama City
Explore the most affordable flight options available from Myrtle Beach to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 8, 2025.