How long is the flight from Panama City to Greenville?

For as low as $604, United Airlines can have you in Greenville from Panama City in 24h 15m. There are 1792 mi between Panama City and Greenville.

In terms of precipitation, rainfall in Greenville ranges from 3.6 - 5.1 inches per month. March is typically the wettest month, when rainfall can reach 5.1 in. November is typically the driest time to visit Greenville when rainfall is around 3.6 in.

If weather is an important factor for your trip to Greenville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

What is the cheapest time of day to fly from PTY to GSP?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Greenville as you normally would.

Most accurate provider : When it comes to deals on Panama City-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Greenville flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Panama City-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Panama City to Greenville that include hotel bookings?

Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to Greenville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

Can I find deals for business class flights from Panama City to Greenville?

Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$346+ Cheap Flights from Panama City to Greenville

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Cheap flight deals from Panama City to Greenville

Cheapest

Best

Last-minute

One-way

Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.

Mon 11/910:00 am -

1 stop13h 00m

Sun 11/225:37 pm -

2 stops26h 25m

Deal found 9/12

$604

Thu 11/1210:00 am -

1 stop13h 00m

Mon 11/165:37 pm -

2 stops21h 08m

Deal found 9/13

$618

Thu 10/292:02 pm -

1 stop28h 36m

Thu 11/58:12 pm -

1 stop18h 01m

Deal found 9/16

$717

Thu 10/293:41 pm -

2 stops20h 49m

Thu 11/52:51 pm -

2 stops23h 54m

Deal found 9/16

$729

One-way flights from Panama City to Greenville
Search for one-way flight options from Panama City to Greenville. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.

Wed 12/210:00 am -

1 stop13h 40m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 9/17

$346

Tue 1/124:41 pm -

2 stops28h 05m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 9/12

$424

Sat 11/283:34 pm -

1 stop9h 25m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 9/17

$543

Sat 11/287:00 pm -

3 stops49h 12m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 9/17

$622

Tue 1/124:00 pm -

3 stops41h 32m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 9/12

$624

Find flight deals from Panama City to Greenville

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$604 (United Airlines)
One-way from	$346 (United Airlines)

Provider with most accurate pricing for Panama City Tocumen Intl-Greenville flight deals.

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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Greenville flights.

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From Panama City Tocumen Intl to Greenville

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One-way flight from Panama City Tocumen Intl to Greenville

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Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Wed 12/2

8:55 am-8:59 pm

2 stops12h 04m

Greenville

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$346

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Tue 1/12

4:41 pm-8:46 pm

2 stops28h 05m

Greenville

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$424

Quickest round-trip

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Sat 11/28

3:34 pm-12:59 am

1 stop9h 25m

Greenville

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$543

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Mon 11/9

4:41 pm-4:56 pm

2 stops24h 15m

Greenville

Sun 11/22

5:37 pm-8:02 pm

2 stops26h 25m

$604

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Thu 11/12

10:00 am-11:00 pm

1 stop13h 00m

Greenville

Mon 11/16

5:37 pm-2:45 pm

2 stops21h 08m

$618

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Sat 11/28

7:00 pm-8:12 pm

3 stops49h 12m

Greenville

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$622

Panama CityGreenville

PTY Panama City Tocumen Intl - GSP Greenville

PTYGSP

Panama City Tocumen Intl

Tue 1/12

4:00 pm-9:32 am

3 stops41h 32m

Greenville

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$624

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Sorted by cheapest first

Most accurate provider: When it comes to deals on Panama City-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Greenville flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Panama City-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.

PTY-GSP

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

How long is the flight from Panama City to Greenville?
For as low as $604, United Airlines can have you in Greenville from Panama City in 24h 15m. There are 1792 mi between Panama City and Greenville.
Can I find deals for flights from Panama City to Greenville that include hotel bookings?
Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Greenville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.
Can I find deals for business class flights from Panama City to Greenville?
Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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$346+ Cheap flights from Panama City (PTY) to Greenville (GSP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/2. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Greenville with Cheapflights

1. Tell us where you want to go

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3. Compare prices and book

Cheap flight deals from Panama City to Greenville

Cheapest flights from Panama City to GreenvilleExplore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.

Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.

Best flights from Panama City to GreenvilleDiscover carefully curated flight deals from Panama City to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.

Discover carefully curated flight deals from Panama City to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.

Last-minute flights from Panama City to GreenvilleDiscover last-minute flight deals from Panama City to Greenville. Data last updated September 17, 2026 and is based on user searches.

Discover last-minute flight deals from Panama City to Greenville. Data last updated September 17, 2026 and is based on user searches.

One-way flights from Panama City to GreenvilleSearch for one-way flight options from Panama City to Greenville. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.

Search for one-way flight options from Panama City to Greenville. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.

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Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.

Related info for your journey

How long is the flight from Panama City to Greenville?

Can I find deals for flights from Panama City to Greenville that include hotel bookings?

How can I find direct flights from Panama City to Greenville?

Can I find deals for business class flights from Panama City to Greenville?

Traveling to a place near Greenville?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama City to Greenville

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Complete your trip

Complete your trip to Greenville by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Panama City to Greenville by cabin class

Find flights from Panama City to Greenville, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Other flights to Greenville

Explore flights to Greenville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 17, 2026.

Panama City and Greenville flights

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Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.

Best flights from Panama City to Greenville
Discover carefully curated flight deals from Panama City to Greenville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.

Last-minute flights from Panama City to Greenville
Discover last-minute flight deals from Panama City to Greenville. Data last updated September 17, 2026 and is based on user searches.

One-way flights from Panama City to Greenville
Search for one-way flight options from Panama City to Greenville. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.