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$351+ Cheap flights from Panama City (PTY) to Greenville (GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/13. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — GSP
Aug 19 — Aug 261
Wed 8/19
Wed 8/26
1 adult, Economy
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Cheap flight deals from Panama City to Greenville

Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 20, 2026.

This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:55 am
PTY
-
GSP
3 stops24h 51m
United Airlines
Mon 11/22:20 pm
GSP
-
PTY
2 stops24h 25m
United Airlines
Deal found 7/15$586
This United Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:55 pm
PTY
-
GSP
1 stop23h 08m
United Airlines
Thu 9/107:00 am
GSP
-
PTY
1 stop13h 31m
United Airlines
Deal found 7/19$643
This United Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/103:30 pm
PTY
-
GSP
2 stops21h 02m
United Airlines
Fri 8/286:30 am
GSP
-
PTY
2 stops13h 07m
United Airlines
Deal found 7/18$714
This Mytrip deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:30 am
PTY
-
GSP
3 stops32h 23m
Multiple Airlines
Mon 8/246:58 pm
GSP
-
PTY
3 stops16h 32m
Multiple Airlines
Deal found 7/19$1,642

Find flight deals from Panama City to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$586
(United Airlines)

One-way from

$351
(United Airlines)
Provider with most accurate pricing for Panama City Tocumen Intl-Greenville flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Greenville flights.
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From Panama City Tocumen Intl to Greenville
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One-way flight from Panama City Tocumen Intl to Greenville
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 20, 2026.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 10/29

9:30 am-11:37 pm

1 stop13h 07m

Greenville

Mon 11/2

2:20 pm-2:45 pm

2 stops24h 25m

$586

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 9/3

10:55 pm-11:03 pm

1 stop23h 08m

Greenville

Thu 9/10

7:00 am-7:31 pm

1 stop13h 31m

$643
Quickest round-trip

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Mon 8/10

3:30 pm-1:32 pm

2 stops21h 02m

Greenville

Fri 8/28

6:30 am-6:37 pm

2 stops13h 07m

$714
Cheapest one-way

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Sun 9/13

3:30 pm-9:58 pm

1 stop29h 28m

$351

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Sun 9/13

1:16 pm-10:23 am

2 stops20h 07m

$371
Quickest one-way

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Mon 8/31

4:25 am-7:33 pm

2 stops14h 08m

$407

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Mon 8/31

3:30 pm-5:20 pm

1 stop24h 50m

$408

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Sun 9/13

9:33 pm-5:14 pm

3 stops42h 41m

$453

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Sun 7/26

9:45 am-10:37 am

1 stop23h 52m

$498

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Sun 7/26

4:25 am-5:39 pm

3 stops36h 14m

$593

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/17

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Panama City-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Greenville?

    For as low as $586, United Airlines can have you in Greenville from Panama City in 17h 05m. There are 1792 mi between Panama City and Greenville.

  • Can I find deals for flights from Panama City to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

  • Can I find deals for business class flights from Panama City to Greenville?

    Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Greer
Simpsonville
Greenwood
Duncan
Seneca

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