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Greenville

$360+ Cheap flights from Panama City (PTY) to Greenville (GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/13. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — GSP
May 19 — May 261
Tue 5/19
Tue 5/26
1 adult, Economy
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Cheap flight deals from Panama City to Greenville

Cheapest flights from Panama City to Greenville
Explore the most affordable flight options available from Panama City to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 19, 2026.

This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/13:40 pm
PTY
-
GSP
2 stops22h 11m
American Airlines
Sun 10/48:40 pm
GSP
-
PTY
2 stops18h 20m
American Airlines
Deal found 4/14$500
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:15 pm
PTY
-
GSP
1 stop25h 02m
Delta
Tue 5/195:40 am
GSP
-
PTY
1 stop8h 10m
Delta
Deal found 4/14$561
This KAYAK deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/12:21 pm
PTY
-
GSP
1 stop18h 06m
LATAM Airlines
Sun 10/46:45 am
GSP
-
PTY
1 stop7h 11m
LATAM Airlines
Deal found 4/14$589
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:15 pm
PTY
-
GSP
1 stop20h 50m
Delta
Sun 5/175:40 am
GSP
-
PTY
1 stop8h 10m
Delta
Deal found 4/14$593
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/141:49 pm
PTY
-
GSP
2 stops25h 11m
American Airlines
Sun 5/176:45 pm
GSP
-
PTY
1 stop19h 01m
American Airlines
Deal found 4/14$641
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:15 pm
PTY
-
GSP
1 stop25h 02m
Delta
Mon 5/187:42 pm
GSP
-
PTY
1 stop18h 08m
Delta
Deal found 4/14$643
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/161:49 pm
PTY
-
GSP
2 stops20h 12m
American Airlines
Sun 4/195:20 am
GSP
-
PTY
2 stops8h 26m
American Airlines
Deal found 4/15$644
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/162:15 pm
PTY
-
GSP
1 stop17h 49m
Delta
Tue 5/195:40 am
GSP
-
PTY
1 stop8h 10m
Delta
Deal found 4/14$670
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:55 am
PTY
-
GSP
1 stop13h 19m
United Airlines
Fri 5/156:27 pm
GSP
-
PTY
1 stop10h 37m
United Airlines
Deal found 4/14$672
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:15 pm
PTY
-
GSP
1 stop17h 52m
Delta
Sun 5/177:42 pm
GSP
-
PTY
1 stop18h 08m
Delta
Deal found 4/14$675
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/121:49 pm
PTY
-
GSP
2 stops28h 55m
American Airlines
Mon 5/186:45 pm
GSP
-
PTY
1 stop19h 01m
American Airlines
Deal found 4/14$678
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/162:27 pm
PTY
-
GSP
1 stop6h 46m
Delta
Sun 4/196:51 am
GSP
-
PTY
1 stop7h 11m
Delta
Deal found 4/15$685

Find flight deals from Panama City to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 19, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$500
(American Airlines)

One-way from

$360
(Delta)
Provider with most accurate pricing for Panama City Tocumen Intl-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Greenville flights.
Search Deals
From Panama City Tocumen Intl to Greenville
Search Deals
One-way flight from Panama City Tocumen Intl to Greenville
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 19, 2026.
Use the filters below to find and compare flights from Panama City to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Wed 5/13

2:15 pm-11:43 pm

1 stop8h 28m

Greenville

Tue 5/19

5:40 am-12:50 pm

1 stop8h 10m

$561

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Sat 5/16

2:15 pm-9:04 am

1 stop17h 49m

Greenville

Tue 5/19

5:40 am-12:50 pm

1 stop8h 10m

$670

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Mon 5/11

7:55 am-10:14 pm

1 stop13h 19m

Greenville

Tue 5/19

7:00 am-6:37 pm

1 stop12h 37m

$672

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 5/12

7:55 am-10:14 pm

1 stop13h 19m

Greenville

Wed 5/20

5:45 pm-2:14 pm

2 stops21h 29m

$672

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Wed 5/13

10:00 am-10:14 pm

1 stop11h 14m

Greenville

Wed 5/20

5:45 pm-2:14 pm

2 stops21h 29m

$672

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 5/15

7:55 am-10:14 pm

1 stop13h 19m

Greenville

Tue 5/19

2:45 pm-2:14 pm

2 stops24h 29m

$693

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Mon 5/11

7:55 am-10:14 pm

1 stop13h 19m

Greenville

Thu 5/14

7:00 am-4:12 pm

1 stop10h 12m

$786

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Mon 6/15

1:14 pm-10:50 am

2 stops20h 36m

Greenville

Fri 6/19

7:32 pm-12:14 pm

2 stops17h 42m

$831
Cheapest one-way

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Wed 5/13

10:00 am-10:14 pm

1 stop11h 14m

$364

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Wed 5/13

1:49 pm-12:19 pm

2 stops21h 30m

$374

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/14

Showing 1-10 of 12 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Panama City-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City-Greenville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City to Greenville?

    For as low as $589, American Airlines can have you in Greenville from Panama City in 18h 06m. There are 1792 mi between Panama City and Greenville. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Panama City to Greenville that include hotel bookings?

    Yes. In addition to deals on Panama City to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Greenville.

  • Can I find deals for business class flights from Panama City to Greenville?

    Yes. Cheapflights offers flight deals from Panama City to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Greer
Simpsonville
Duncan
Seneca
Anderson

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See prices for flight routes from nearby airports that may be better suited for you.
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