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South Carolina

$311+ Cheap flights from Panama City (PTY) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/23. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Aug 20 — Aug 271
Thu 8/20
Thu 8/27
1 adult, Economy
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Cheap flight deals from Panama City to South Carolina

Cheapest flights from Panama City to South Carolina
Explore the most affordable flight options available from Panama City to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 21, 2026.

This Copa Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:41 pm
PTY
-
CLT
1 stop14h 03m
Copa Airlines
Fri 10/166:00 am
CLT
-
PTY
1 stop8h 31m
Copa Airlines
Deal found 7/16$560
This United Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/169:45 am
PTY
-
CLT
1 stop9h 59m
United Airlines
Mon 10/57:00 am
CLT
-
PTY
1 stop13h 31m
United Airlines
Deal found 7/16$572
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:23 pm
PTY
-
CLT
1 stop26h 51m
Delta
Wed 9/169:38 am
CLT
-
PTY
1 stop28h 20m
Delta
Deal found 7/20$573
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:30 am
PTY
-
GSP
1 stop13h 07m
United Airlines
Mon 11/22:20 pm
GSP
-
PTY
2 stops24h 25m
United Airlines
Deal found 7/15$586
This Copa Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:46 pm
PTY
-
CLT
1 stop15h 18m
Copa Airlines
Mon 11/97:55 pm
CLT
-
PTY
1 stop17h 36m
Copa Airlines
Deal found 7/17$589
This American Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:16 pm
PTY
-
CLT
1 stop20h 04m
American Airlines
Mon 9/149:55 pm
CLT
-
PTY
1 stop15h 31m
American Airlines
Deal found 7/18$591
This Delta deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:20 pm
PTY
-
CHS
1 stop8h 39m
Delta
Mon 9/75:10 am
CHS
-
PTY
1 stop8h 45m
Delta
Deal found 7/17$598
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/193:30 pm
PTY
-
CHS
2 stops21h 28m
United Airlines
Tue 8/257:00 am
CHS
-
PTY
1 stop13h 31m
United Airlines
Deal found 7/20$613
This Delta deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/152:23 pm
PTY
-
MYR
1 stop8h 06m
Delta
Tue 9/226:00 am
MYR
-
PTY
1 stop7h 58m
Delta
Deal found 7/16$630
This Delta deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/152:23 pm
PTY
-
AGS
1 stop8h 31m
Delta
Mon 9/215:40 am
AGS
-
PTY
1 stop8h 18m
Delta
Deal found 7/16$630
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:55 pm
PTY
-
CHS
1 stop24h 04m
United Airlines
Sun 8/237:00 am
CHS
-
PTY
1 stop22h 04m
United Airlines
Deal found 7/17$632
This United Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:55 pm
PTY
-
GSP
1 stop23h 08m
United Airlines
Thu 9/107:00 am
GSP
-
PTY
1 stop13h 31m
United Airlines
Deal found 7/19$643

Find flight deals from Panama City to South Carolina

Keep the following information in mind while searching for Panama City to South Carolina flight deals. Data was last updated July 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$560
(Copa Airlines)

One-way from

$319
(Delta)
Provider with most accurate pricing for Panama City Tocumen Intl-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Myrtle Beach Intl flights.
Search Deals
From Panama City Tocumen Intl to South Carolina
Search Deals
One-way flight from Panama City Tocumen Intl to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 21, 2026.
Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Sat 9/26

6:41 pm-9:44 am

1 stop14h 03m

Charlotte Douglas

Fri 10/16

6:00 am-1:31 pm

1 stop8h 31m

$560

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Tue 10/20

10:00 am-10:08 am

2 stops23h 08m

Charlotte Douglas

Thu 10/22

10:25 am-7:31 pm

2 stops10h 06m

$572

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 10/29

7:55 am-9:46 am

3 stops24h 51m

Greenville

Mon 11/2

2:20 pm-2:45 pm

2 stops24h 25m

$586

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Mon 8/31

2:20 pm-11:59 pm

1 stop8h 39m

Charleston

Mon 9/7

5:10 am-12:55 pm

1 stop8h 45m

$598

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 12/23

11:35 am-10:48 am

1 stop23h 13m

Charlotte Douglas

Sat 1/2

6:40 am-7:38 pm

1 stop12h 58m

$604

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Sat 10/31

7:55 am-10:33 pm

3 stops37h 38m

Charlotte Douglas

Mon 11/9

6:00 am-8:02 pm

2 stops14h 02m

$604

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 8/19

3:30 pm-1:58 pm

2 stops21h 28m

Charleston

Tue 8/25

7:00 am-7:31 pm

1 stop13h 31m

$613

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 9/2

9:45 am-8:44 pm

1 stop9h 59m

Charlotte Douglas

Thu 9/17

7:00 am-7:31 pm

1 stop13h 31m

$616

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 9/2

3:30 pm-10:54 am

1 stop18h 24m

Charlotte Douglas

Wed 9/16

9:54 am-7:31 pm

1 stop10h 37m

$625

Panama CityMyrtle Beach

PTY - MYR

PTYMYR

Panama City Tocumen Intl

Tue 9/15

2:23 pm-11:29 pm

1 stop8h 06m

Myrtle Beach Intl

Tue 9/22

6:00 am-12:58 pm

1 stop7h 58m

$630

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/20

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Panama City to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South Carolina

What is the cheapest month to book a flight from Panama City to South Carolina?

Currently, December is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $376). Flying from Panama City to South Carolina in March is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Panama City to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated July 21, 2026.
Read through reviews of airlines operating flights from Panama City to South Carolina, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,836 reviews

Crew

7.9

Entertainment

6.8

Comfort

7.2

Food

6.4

Boarding

7.5

Overall

7.1

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go
American Airlines
7.1
Good
11,836 reviews
American Airlines
7.1
Good
11,836 reviews

Crew

7.9

Entertainment

6.8

Comfort

7.2

Food

6.4

Boarding

7.5

Overall

7.1

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go

Related info for your journey

Find useful and relevant information for your journey from Panama City to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South Carolina?

    Panama City Tocumen Intl (PTY) is the airport you will fly out of if you book a flight from Panama City to South Carolina. It is only a 11.4 mi journey to Tocumen Intl (PTY) from Panama City’s city center.

  • How long is the flight from Panama City to South Carolina?

    Copa Airlines, United Airlines, and Delta can get you from Panama City to South Carolina in just under 8h 39m. Your travel time can differ by up to 5h 24m. The distance between Panama City and South Carolina is about 1645 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Panama City to South Carolina?

    The most popular flight routes from Panama City to South Carolina are Panama City Tocumen Intl - Charlotte Douglas, Panama City Tocumen Intl - Greenville and Panama City Tocumen Intl - Charleston.

  • Can I find deals for flights from Panama City to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama City to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South Carolina.

  • Can I find deals for business class flights from Panama City to South Carolina?

    Yes. Cheapflights offers flight deals from Panama City to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $376). Flying from Panama City to South Carolina in March is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Panama City to South Carolina

Discover the top airline that operate flights from Panama City to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$397Average$577FlexibilityNo cancel feeOn-time71%

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