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South Carolina

$359+ Cheap flights from Panama City (PTY) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/18. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Jun 27 — Jul 41
Sat 6/27
Sat 7/4
1 adult, Economy
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Cheap flight deals from Panama City to South Carolina

Cheapest flights from Panama City to South Carolina
Explore the most affordable flight options available from Panama City to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 28, 2026.

This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/235:30 am
PTY
-
CLT
2 stops10h 42m
Multiple Airlines
Sat 8/16:48 pm
CLT
-
PTY
1 stop14h 18m
Multiple Airlines
Deal found 5/26$508
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:21 pm
PTY
-
CLT
1 stop8h 36m
Delta
Mon 9/146:55 am
CLT
-
PTY
1 stop7h 01m
Delta
Deal found 5/27$530
This United Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/79:45 am
PTY
-
CHS
1 stop13h 07m
United Airlines
Tue 7/1411:13 am
CHS
-
PTY
1 stop17h 51m
United Airlines
Deal found 5/23$549
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:35 pm
PTY
-
CLT
1 stop15h 50m
American Airlines
Wed 10/215:16 am
CLT
-
PTY
1 stop9h 44m
American Airlines
Deal found 5/27$552
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:16 pm
PTY
-
CLT
2 stops16h 07m
American Airlines
Mon 9/141:30 pm
CLT
-
PTY
1 stop23h 54m
American Airlines
Deal found 5/27$554
This American Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/203:35 pm
PTY
-
CLT
1 stop21h 12m
American Airlines
Tue 11/310:14 pm
CLT
-
PTY
2 stops15h 22m
American Airlines
Deal found 5/23$555
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/245:30 am
PTY
-
CLT
2 stops10h 42m
Multiple Airlines
Sat 8/16:48 pm
CLT
-
PTY
1 stop14h 18m
Multiple Airlines
Deal found 5/26$564
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/83:10 pm
PTY
-
CLT
2 stops25h 02m
Multiple Airlines
Sun 7/126:48 pm
CLT
-
PTY
1 stop14h 42m
Multiple Airlines
Deal found 5/23$568
This United Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/177:55 am
PTY
-
CHS
1 stop13h 20m
United Airlines
Tue 11/36:43 pm
CHS
-
PTY
2 stops25h 19m
United Airlines
Deal found 5/26$568
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/254:25 am
PTY
-
CLT
2 stops15h 42m
Multiple Airlines
Sat 8/16:48 pm
CLT
-
PTY
1 stop14h 42m
Multiple Airlines
Deal found 5/26$571
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:16 pm
PTY
-
CLT
2 stops16h 07m
American Airlines
Sat 9/195:20 am
CLT
-
PTY
1 stop7h 55m
American Airlines
Deal found 5/24$575
This United Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/211:35 am
PTY
-
CHS
1 stop10h 19m
United Airlines
Sat 12/56:43 pm
CHS
-
PTY
2 stops22h 24m
United Airlines
Deal found 5/23$582

Find flight deals from Panama City to South Carolina

Keep the following information in mind while searching for Panama City to South Carolina flight deals. Data was last updated May 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$508
(Kiwi.com)

One-way from

$359
(American Airlines)
Provider with most accurate pricing for Panama City Tocumen Intl-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Myrtle Beach Intl flights.
Search Deals
From Panama City Tocumen Intl to South Carolina
Search Deals
One-way flight from Panama City Tocumen Intl to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 28, 2026.
Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 9/10

2:21 pm-11:57 pm

1 stop8h 36m

Charlotte Douglas

Mon 9/14

5:30 am-12:56 pm

1 stop8h 26m

$530

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 10/21

2:21 pm-11:53 pm

1 stop8h 32m

Charlotte Douglas

Wed 11/4

5:30 am-1:56 pm

1 stop8h 26m

$530

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Tue 10/20

2:21 pm-11:53 pm

1 stop8h 32m

Charlotte Douglas

Tue 11/3

5:30 am-1:56 pm

1 stop8h 26m

$530

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 7/7

10:55 pm-11:52 pm

1 stop23h 57m

Charleston

Tue 7/14

11:31 am-4:04 am

2 stops17h 33m

$549

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 7/29

7:55 am-10:23 am

2 stops25h 28m

Charleston

Wed 8/5

6:00 am-4:04 am

2 stops23h 04m

$549

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 7/17

7:55 am-10:15 pm

1 stop13h 20m

Charleston

Tue 11/3

6:43 pm-8:02 pm

2 stops25h 19m

$568
Quickest round-trip

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 6/17

2:24 pm-12:36 am

1 stop9h 12m

Charleston

Mon 6/29

7:20 am-1:09 pm

1 stop6h 49m

$622

Panama CityMyrtle Beach

PTY - MYR

PTYMYR

Panama City Tocumen Intl

Tue 6/16

1:15 pm-11:47 am

2 stops21h 32m

Myrtle Beach Intl

Tue 7/14

7:07 pm-12:14 pm

2 stops18h 07m

$633

Panama CityColumbia

PTY - CAE

PTYCAE

Panama City Tocumen Intl

Wed 10/28

3:41 pm-2:10 pm

2 stops21h 29m

Columbia Metropolitan

Sun 11/1

7:35 pm-8:02 pm

2 stops24h 27m

$633

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 9/10

9:45 am-9:44 am

2 stops22h 59m

Charlotte Douglas

Mon 9/14

7:55 pm-7:31 pm

2 stops24h 36m

$654

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/26

Showing 1-10 of 39 resultsSorted by cheapest first
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Best time to book a flight from Panama City to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South Carolina

What is the cheapest month to book a flight from Panama City to South Carolina?

Currently, December is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $148). Flying from Panama City to South Carolina in March is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Panama City to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated May 28, 2026.
Read through reviews of airlines operating flights from Panama City to South Carolina, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,639 reviews

Comfort

7.2

Crew

7.9

Food

6.4

Entertainment

6.9

Boarding

7.5

Overall

7.1

Reviews

1 / 20
10.0
Excellent

Beatriz,May 2026

HEL - DFW

Very modern and confortable plane. Dinner was delicious. Whole crew were polite and perfect.
American Airlines
7.1
Good
11,639 reviews
American Airlines
7.1
Good
11,639 reviews

Comfort

7.2

Crew

7.9

Food

6.4

Entertainment

6.9

Boarding

7.5

Overall

7.1

Reviews

1 / 20
10.0
Excellent

Beatriz,May 2026

HEL - DFW

Very modern and confortable plane. Dinner was delicious. Whole crew were polite and perfect.

Related info for your journey

Find useful and relevant information for your journey from Panama City to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South Carolina?

    Panama City Tocumen Intl (PTY) is the airport you will fly out of if you book a flight from Panama City to South Carolina. It is only a 11.4 mi journey to Tocumen Intl (PTY) from Panama City’s city center.

  • How long is the flight from Panama City to South Carolina?

    Delta, United Airlines, and American Airlines can get you from Panama City to South Carolina in just under 8h 36m. Your travel time can differ by up to 15h 21m. The distance between Panama City and South Carolina is about 1808 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Panama City to South Carolina?

    The most popular flight routes from Panama City to South Carolina are Panama City Tocumen Intl - Charlotte Douglas, Panama City Tocumen Intl - Charleston and Panama City Tocumen Intl - Columbia Metropolitan.

  • Can I find deals for flights from Panama City to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama City to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South Carolina.

  • Can I find deals for business class flights from Panama City to South Carolina?

    Yes. Cheapflights offers flight deals from Panama City to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $148). Flying from Panama City to South Carolina in March is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top airline flying from Panama City to South Carolina

Discover the top airline that operate flights from Panama City to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$397Average$577FlexibilityNo cancel feeOn-time71%

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