$368+ Cheap flights from Panama City (PTY) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Nov 29 — Dec 61
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to South Carolina
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Cheapest flights from Panama City to South CarolinaExplore the most affordable flight options available from Panama City to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from Panama City to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/174:41 pm -
2 stops21h 19m
Sun 1/36:00 am -
1 stop14h 02m
Deal found 10/28![United Airlines logo]()
$719
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/34:41 pm -
2 stops26h 42m
Mon 12/75:45 pm -
2 stops26h 17m
Deal found 10/29![United Airlines logo]()
$792
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:55 am -
1 stop7h 08m
Wed 12/92:57 pm -
1 stop29h 22m
Deal found 10/28![Multiple Airlines logo]()
$813
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:55 am -
1 stop7h 08m
Fri 12/116:12 pm -
2 stops26h 07m
Deal found 10/28![Multiple Airlines logo]()
$827
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:55 am -
1 stop7h 08m
Mon 12/76:12 pm -
2 stops26h 07m
Deal found 10/28![Multiple Airlines logo]()
$831
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/23:29 pm -
1 stop18h 38m
Mon 12/76:57 pm -
1 stop19h 06m
Deal found 10/28![Delta logo]()
$844
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:55 am -
1 stop7h 08m
Thu 12/106:25 pm -
2 stops22h 40m
Deal found 10/28![Multiple Airlines logo]()
$853
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1310:00 am -
1 stop13h 59m
Mon 11/167:00 am -
1 stop13h 02m
Deal found 10/29![United Airlines logo]()
$857
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/13:29 pm -
1 stop18h 38m
Mon 12/76:57 pm -
1 stop19h 06m
Deal found 10/28![Delta logo]()
$875
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/43:29 pm -
1 stop7h 18m
Mon 12/76:57 pm -
1 stop19h 06m
Deal found 10/28![Delta logo]()
$876
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1312:10 pm -
1 stop19h 53m
Sun 12/208:10 pm -
1 stop20h 55m
Deal found 10/29![Multiple Airlines logo]()
$882
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/112:10 pm -
1 stop21h 18m
Tue 12/84:03 pm -
1 stop28h 16m
Deal found 10/28![Multiple Airlines logo]()
$884
Best flights from Panama City to South CarolinaDiscover carefully curated flight deals from Panama City to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from Panama City to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/168:55 am -
1 stop13h 04m
Wed 2/244:58 pm -
1 stop26h 40m
Deal found 10/28![United Airlines logo]()
$680
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/13:29 pm -
1 stop18h 38m
Fri 12/116:59 pm -
1 stop19h 04m
Deal found 10/28![Delta logo]()
$1,223
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/612:10 pm -
1 stop19h 53m
Sun 12/136:25 pm -
1 stop13h 53m
Deal found 10/28![Multiple Airlines logo]()
$1,292
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/214:41 pm -
2 stops21h 43m
Mon 1/252:26 pm -
2 stops24h 19m
Deal found 10/29![United Airlines logo]()
$682
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/194:41 pm -
1 stop23h 19m
Thu 1/217:51 pm -
2 stops21h 21m
Deal found 10/29![United Airlines logo]()
$719
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/34:41 pm -
2 stops26h 42m
Mon 12/75:45 pm -
2 stops26h 17m
Deal found 10/29![United Airlines logo]()
$792
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/53:29 pm -
1 stop22h 04m
Fri 12/116:59 pm -
1 stop19h 04m
Deal found 10/28![Delta logo]()
$1,224
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/710:00 am -
1 stop24h 49m
Sun 12/136:15 pm -
1 stop25h 47m
Deal found 10/28![United Airlines logo]()
$1,616
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/510:00 am -
1 stop24h 49m
Sun 12/136:15 pm -
1 stop25h 47m
Deal found 10/28![United Airlines logo]()
$1,648
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1310:00 am -
1 stop24h 49m
Sun 12/204:02 pm -
1 stop13h 08m
Deal found 10/29![United Airlines logo]()
$2,116
Last-minute flights from Panama City to South CarolinaDiscover last-minute flight deals from Panama City to South Carolina. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to South Carolina. Data last updated October 30, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/23:13 pm -
2 stops19h 00m
Sat 11/76:37 pm -
2 stops19h 36m
Deal found 10/27![American Airlines logo]()
$1,226
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/210:00 am -
1 stop25h 41m
Sat 11/75:37 pm -
2 stops26h 01m
Deal found 10/27![United Airlines logo]()
$1,230
This BusinessClass deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/29:11 am -
1 stop9h 57m
Sat 11/77:54 pm -
1 stop17h 37m
Deal found 10/26![Copa Airlines logo]()
$1,362
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/610:00 am -
1 stop24h 21m
Mon 11/911:27 am -
1 stop8h 35m
Deal found 10/29![United Airlines logo]()
$1,689
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1310:00 am -
1 stop13h 59m
Mon 11/167:00 am -
1 stop13h 02m
Deal found 10/29![United Airlines logo]()
$857
One-way flights from Panama City to South CarolinaSearch for one-way flight options from Panama City to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
Search for one-way flight options from Panama City to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1410:00 am -
2 stops27h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![United Airlines logo]()
$368
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/248:55 am -
1 stop13h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![United Airlines logo]()
$373
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/177:55 am -
1 stop12h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![United Airlines logo]()
$378
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/153:13 pm -
2 stops19h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![American Airlines logo]()
$382
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/173:24 pm -
2 stops17h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$388
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/88:00 am -
1 stop28h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![Delta logo]()
$405
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/88:00 am -
1 stop11h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Delta logo]()
$413
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/242:41 pm -
2 stops26h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$423
This KAYAK deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1510:00 am -
1 stop25h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Copa Airlines logo]()
$451
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/810:25 am -
3 stops45h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![Multiple Airlines logo]()
$474
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/912:03 pm -
1 stop7h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Multiple Airlines logo]()
$477
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/109:31 pm -
3 stops35h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![Multiple Airlines logo]()
$488
Find flight deals from Panama City to South Carolina
Keep the following information in mind while searching for Panama City to South Carolina flight deals. Data was last updated October 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $680 (United Airlines) |
One-way from | $368 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityColumbia
PTY Panama City Tocumen Intl - CAE Columbia Metropolitan
PTYCAE
Panama City Tocumen Intl
Tue 12/15
4:41 pm-5:09 pm
2 stops24h 28m
Columbia Metropolitan
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$368
Panama CityColumbia
PTY Panama City Tocumen Intl - CAE Columbia Metropolitan
PTYCAE
Panama City Tocumen Intl
Mon 12/14
10:00 am-11:45 am
1 stop25h 45m
Columbia Metropolitan
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$368
Panama CityCharleston
PTY Panama City Tocumen Intl - CHS Charleston
PTYCHS
Panama City Tocumen Intl
Thu 12/24
8:55 am-10:02 pm
1 stop13h 07m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$373
Panama CityCharleston
PTY Panama City Tocumen Intl - CHS Charleston
PTYCHS
Panama City Tocumen Intl
Wed 3/17
7:55 am-9:45 pm
1 stop12h 50m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$378
Panama CityColumbia
PTY Panama City Tocumen Intl - CAE Columbia Metropolitan
PTYCAE
Panama City Tocumen Intl
Tue 12/15
3:13 pm-10:14 am
2 stops19h 01m
Columbia Metropolitan
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$382
Panama CityCharleston
PTY Panama City Tocumen Intl - CHS Charleston
PTYCHS
Panama City Tocumen Intl
Wed 3/17
3:24 pm-10:23 am
2 stops17h 59m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$388
Panama CityColumbia
PTY Panama City Tocumen Intl - CAE Columbia Metropolitan
PTYCAE
Panama City Tocumen Intl
Sun 1/10
8:00 am-10:07 am
1 stop26h 07m
Columbia Metropolitan
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$405
Panama CityColumbia
PTY Panama City Tocumen Intl - CAE Columbia Metropolitan
PTYCAE
Panama City Tocumen Intl
Fri 1/8
8:00 am-12:15 pm
1 stop28h 15m
Columbia Metropolitan
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$405
Panama CityCharleston
PTY Panama City Tocumen Intl - CHS Charleston
PTYCHS
Panama City Tocumen Intl
Sun 1/10
8:00 am-3:51 pm
1 stop7h 51m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$413
Panama CityCharleston
PTY Panama City Tocumen Intl - CHS Charleston
PTYCHS
Panama City Tocumen Intl
Fri 1/8
8:00 am-7:54 pm
1 stop11h 54m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$413
Showing 1-10 of 29 resultsSorted by cheapest first
Best time to book a flight from Panama City to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama City with our price prediction graph.
PTY-CHS
PTY-CAE
PTY-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to South Carolina
PTY-USSC
PTY-CHS
PTY-CAE
PTY-MYR
What is the cheapest month to book a flight from Panama City to South Carolina?
Currently, December is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $376). Flying from Panama City to South Carolina in October is currently the most expensive (average of $869). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 30, 2026.
Read through reviews of airlines operating flights from Panama City to South Carolina, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Crew
7.9
Comfort
7.1
Overall
7.0
Boarding
7.4
Food
6.4
Reviews
1 / 20
2.0
MediocreSherif,Aug 2026
YYZ - ORD
Entertainment
6.8
Crew
7.9
Comfort
7.1
Overall
7.0
Boarding
7.4
Food
6.4
Reviews
1 / 20
2.0
MediocreSherif,Aug 2026
YYZ - ORD
Related info for your journey
Find useful and relevant information for your journey from Panama City to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Panama City to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama City to South Carolina by cabin class
Find flights from Panama City to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama City and South Carolina flights
Browse other Panama City and South Carolina flight options. Last updated on October 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Panama City to South Carolina flights
Consider these flights traveling from Panama City to South Carolina.
Top airline flying from Panama City to South Carolina
Discover the top airline that operate flights from Panama City to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$431 | Average$642 | FlexibilityNo cancel fee | On-time71% |