HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$180+ Cheap flights from South Carolina to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/24. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Mar 7 — Mar 141
Sat 3/7
Sat 3/14
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from South Carolina to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from South Carolina to Panama City

Cheapest flights from South Carolina to Panama City
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.

This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/511:10 am
CHS
-
PTY
1 stop8h 52m
United Airlines
Thu 3/123:41 pm
PTY
-
CHS
1 stop23h 27m
United Airlines
Deal found 2/3$399
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/107:49 pm
GSP
-
PTY
1 stop9h 15m
United Airlines
Wed 8/1210:55 pm
PTY
-
GSP
1 stop10h 42m
United Airlines
Deal found 2/4$413
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/148:17 pm
CHS
-
PTY
2 stops19h 03m
American Airlines
Tue 3/173:10 pm
PTY
-
CHS
1 stop7h 49m
American Airlines
Deal found 2/4$415
This American Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:05 pm
GSP
-
PTY
2 stops19h 41m
American Airlines
Wed 5/201:49 pm
PTY
-
GSP
1 stop9h 10m
American Airlines
Deal found 2/5$417
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:50 am
GSP
-
PTY
1 stop10h 17m
United Airlines
Tue 8/1110:55 pm
PTY
-
GSP
1 stop10h 42m
United Airlines
Deal found 2/2$419
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:40 pm
CHS
-
PTY
1 stop9h 24m
United Airlines
Sun 4/193:30 pm
PTY
-
CHS
1 stop29h 29m
United Airlines
Deal found 2/2$420
This Gurufare deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/711:10 am
CHS
-
PTY
1 stop18h 00m
Multiple Airlines
Mon 3/99:30 am
PTY
-
CHS
1 stop13h 00m
Multiple Airlines
Deal found 2/3$421
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:12 pm
CLT
-
PTY
2 stops22h 48m
Multiple Airlines
Tue 3/32:55 am
PTY
-
CLT
2 stops17h 17m
Multiple Airlines
Deal found 2/3$424
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:44 pm
GSP
-
PTY
1 stop20h 36m
American Airlines
Wed 8/123:20 pm
PTY
-
GSP
2 stops25h 20m
American Airlines
Deal found 2/4$426
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/234:36 pm
GSP
-
PTY
1 stop27h 02m
United Airlines
Tue 8/1110:55 pm
PTY
-
GSP
1 stop10h 42m
United Airlines
Deal found 2/2$427
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:21 pm
CHS
-
PTY
2 stops17h 25m
American Airlines
Sun 4/191:49 pm
PTY
-
CHS
1 stop19h 45m
American Airlines
Deal found 2/2$429
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:00 am
CHS
-
PTY
1 stop12h 37m
United Airlines
Sun 6/147:55 am
PTY
-
CHS
1 stop13h 17m
United Airlines
Deal found 2/3$431

Find flight deals from South Carolina to Panama City

Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated February 5, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$399
(United Airlines)

One-way from

$180
(United Airlines)
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
Search Deals
From South Carolina to Panama City Tocumen Intl
Search Deals
One-way flight from South Carolina to Panama City Tocumen Intl
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

South Carolina

Fly to

Panama City

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 3/5

11:10 am-8:02 pm

1 stop8h 52m

Panama City Tocumen Intl

Thu 3/12

3:41 pm-4:08 pm

1 stop23h 27m

$399

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 4/21

7:40 pm-4:04 am

1 stop9h 24m

Panama City Tocumen Intl

Thu 4/23

3:30 pm-4:11 pm

1 stop23h 41m

$399

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 5/6

6:00 am-12:46 pm

1 stop7h 46m

Panama City Tocumen Intl

Wed 5/20

1:49 pm-11:59 pm

1 stop9h 10m

$413

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 3/14

6:45 pm-2:20 pm

2 stops20h 35m

Panama City Tocumen Intl

Tue 3/17

1:40 pm-11:34 am

2 stops20h 54m

$415

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 2/24

6:50 am-7:38 pm

1 stop12h 48m

Panama City Tocumen Intl

Wed 8/5

10:55 pm-10:37 am

1 stop10h 42m

$419

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 2/24

6:50 am-5:07 pm

1 stop10h 17m

Panama City Tocumen Intl

Tue 8/11

10:55 pm-10:37 am

1 stop10h 42m

$419

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 4/21

6:40 am-2:14 pm

1 stop8h 34m

Panama City Tocumen Intl

Fri 4/24

3:30 pm-9:59 pm

1 stop29h 29m

$420

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 4/16

7:40 pm-4:04 am

1 stop9h 24m

Panama City Tocumen Intl

Sun 4/19

3:30 pm-9:59 pm

1 stop29h 29m

$420

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 2/24

6:50 am-7:38 pm

1 stop12h 48m

Panama City Tocumen Intl

Mon 8/10

3:30 pm-3:18 pm

1 stop22h 48m

$427

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 2/23

4:36 pm-5:07 pm

1 stop24h 31m

Panama City Tocumen Intl

Wed 8/5

10:55 pm-10:37 am

1 stop10h 42m

$427

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/3

Showing 1-10 of 44 results
1
2
3
...
5

Best time to book a flight from South Carolina to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama City

What is the cheapest month to book a flight from South Carolina to Panama City?

Currently, July is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $230). Flying from South Carolina to Panama City in December is currently the most expensive (average of $482). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from South Carolina to Panama City?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from South Carolina?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Panama City from South Carolina.

  • How long is the flight from South Carolina to Panama City?

    A quick flight from South Carolina to Panama City can take about 7h 19m. United Airlines provides one of the quickest options available for as low as $477. There are 1596 mi between South Carolina and Panama City. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from South Carolina to Panama City?

    The most popular route from South Carolina to Panama City is Charlotte Douglas - Panama City Tocumen Intl. You may also consider Charleston - Panama City Tocumen Intl or Greenville - Panama City Tocumen Intl.

  • Can I find deals for flights from South Carolina to Panama City that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama City.

  • Can I find deals for business class flights from South Carolina to Panama City?

    Yes. Cheapflights offers flight deals from South Carolina to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama City?

    Currently, July is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $230). Flying from South Carolina to Panama City in December is currently the most expensive (average of $482). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Panama City flights
Newark to Panama City flights
Dulles Intl to Panama City flights
LaGuardia to Panama City flights
Miami to Panama City flights
O'Hare Intl to Panama City flights
Boston to Panama City flights
Los Angeles to Panama City flights
Baltimore to Panama City flights
Dallas/Fort Worth to Panama City flights
Orlando to Panama City flights
Atlanta to Panama City flights
Hobby to Panama City flights
Reagan-National to Panama City flights
Tampa to Panama City flights
George Bush Intcntl to Panama City flights
San Francisco to Panama City flights
Austin to Panama City flights
Denver to Panama City flights
Fort Lauderdale to Panama City flights
Raleigh to Panama City flights
Norfolk to Panama City flights
Midway to Panama City flights
Seattle to Panama City flights
Nashville to Panama City flights
Charlotte to Panama City flights
San Diego to Panama City flights
Jacksonville to Panama City flights
Ontario to Panama City flights
San Antonio to Panama City flights
Greensboro to Panama City flights
Philadelphia to Panama City flights
Detroit to Panama City flights
Cleveland to Panama City flights
Las Vegas to Panama City flights
St. Louis to Panama City flights
Sky Harbor Intl to Panama City flights
Indianapolis to Panama City flights
Columbus to Panama City flights
Minneapolis to Panama City flights
Cincinnati to Panama City flights
Hartford to Panama City flights
Omaha to Panama City flights
Louisville to Panama City flights
West Palm Beach to Panama City flights
Fayetteville to Panama City flights
Des Moines to Panama City flights
Charleston to Panama City flights
Fargo to Panama City flights
Greenville to Panama City flights

Top 3 airlines flying from South Carolina to Panama City

Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$309Average$519FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$353Average$575FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$369Average$466FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2026 Cheapflights