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Panama City

$237+ Cheap flights from South Carolina to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/2. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Aug 17 — Aug 241
Mon 8/17
Mon 8/24
1 adult, Economy
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Cheap flight deals from South Carolina to Panama City

Cheapest flights from South Carolina to Panama City
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 18, 2026.

This Copa Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:00 am
CLT
-
PTY
1 stop14h 35m
Copa Airlines
Wed 11/186:46 pm
PTY
-
CLT
1 stop15h 18m
Copa Airlines
Deal found 7/13$533
This Copa Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2610:24 am
CLT
-
PTY
1 stop10h 11m
Copa Airlines
Sat 12/56:46 pm
PTY
-
CLT
1 stop14h 58m
Copa Airlines
Deal found 7/14$539
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/33:59 pm
CLT
-
PTY
1 stop13h 05m
United Airlines
Mon 9/73:30 pm
PTY
-
CLT
2 stops17h 54m
United Airlines
Deal found 7/13$543
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/87:05 am
CHS
-
PTY
1 stop6h 53m
Delta
Mon 9/282:23 pm
PTY
-
CHS
1 stop8h 34m
Delta
Deal found 7/15$557
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/159:55 pm
CLT
-
PTY
1 stop15h 31m
American Airlines
Fri 9/181:16 pm
PTY
-
CLT
1 stop9h 38m
American Airlines
Deal found 7/15$559
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:45 am
CHS
-
PTY
2 stops14h 46m
United Airlines
Tue 9/299:45 am
PTY
-
CHS
1 stop13h 14m
United Airlines
Deal found 7/15$561
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/64:56 pm
CHS
-
PTY
1 stop20h 59m
Delta
Thu 9/102:23 pm
PTY
-
CHS
1 stop8h 34m
Delta
Deal found 7/14$564
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:30 am
CHS
-
PTY
2 stops22h 34m
United Airlines
Mon 8/313:30 pm
PTY
-
CHS
2 stops21h 28m
United Airlines
Deal found 7/13$565
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:29 pm
GSP
-
PTY
1 stop8h 35m
United Airlines
Mon 9/710:55 pm
PTY
-
GSP
1 stop15h 08m
United Airlines
Deal found 7/13$567
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:00 am
CHS
-
PTY
1 stop13h 31m
United Airlines
Thu 10/83:30 pm
PTY
-
CHS
1 stop29h 51m
United Airlines
Deal found 7/14$567
This United Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:25 am
CLT
-
PTY
1 stop9h 06m
United Airlines
Mon 9/149:45 am
PTY
-
CLT
1 stop30h 15m
United Airlines
Deal found 7/16$567
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1711:10 am
CHS
-
PTY
1 stop17h 54m
United Airlines
Thu 9/179:45 am
PTY
-
CHS
1 stop13h 14m
United Airlines
Deal found 7/15$569

Find flight deals from South Carolina to Panama City

Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated July 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$533
(Copa Airlines)

One-way from

$237
(Copa Airlines)
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
Search Deals
From South Carolina to Panama City Tocumen Intl
Search Deals
One-way flight from South Carolina to Panama City Tocumen Intl
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 18, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 9/3

7:00 am-7:31 pm

1 stop13h 31m

Panama City Tocumen Intl

Mon 9/7

10:55 pm-5:00 pm

1 stop17h 05m

$539

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Fri 9/25

6:00 am-8:35 pm

1 stop15h 35m

Panama City Tocumen Intl

Wed 9/30

6:41 pm-9:44 am

1 stop14h 03m

$539

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 11/26

10:24 am-8:35 pm

1 stop10h 11m

Panama City Tocumen Intl

Sat 12/5

6:46 pm-9:44 am

1 stop14h 58m

$539

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 9/23

9:54 am-7:31 pm

1 stop10h 37m

Panama City Tocumen Intl

Wed 9/30

9:45 am-10:08 am

2 stops23h 23m

$543

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 11/26

7:55 pm-1:31 pm

1 stop17h 36m

Panama City Tocumen Intl

Sun 12/6

10:29 pm-9:44 am

1 stop11h 15m

$559

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 10/1

10:20 am-7:31 pm

2 stops10h 11m

Panama City Tocumen Intl

Mon 10/12

3:30 pm-10:40 am

2 stops18h 10m

$561

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Thu 9/10

7:00 am-7:31 pm

1 stop13h 31m

Panama City Tocumen Intl

Mon 9/14

10:00 am-10:24 am

2 stops23h 24m

$563

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Thu 8/27

7:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Mon 8/31

3:30 pm-1:58 pm

2 stops21h 28m

$565

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 9/2

8:29 pm-4:04 am

1 stop8h 35m

Panama City Tocumen Intl

Mon 9/7

10:55 pm-3:03 pm

1 stop15h 08m

$567

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 9/23

7:00 am-7:31 pm

1 stop13h 31m

Panama City Tocumen Intl

Wed 9/30

9:45 am-10:59 pm

1 stop12h 14m

$567

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/13

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from South Carolina to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama City

What is the cheapest month to book a flight from South Carolina to Panama City?

Currently, March is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $487). Flying from South Carolina to Panama City in December is currently the most expensive (average of $861). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from South Carolina?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Panama City from South Carolina.

  • How long is the flight from South Carolina to Panama City?

    A quick flight from South Carolina to Panama City can take about 8h 09m. United Airlines provides one of the quickest options available for as low as $583. There are 1792 mi between South Carolina and Panama City. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from South Carolina to Panama City?

    The most popular route from South Carolina to Panama City is Charlotte Douglas - Panama City Tocumen Intl. You may also consider Charleston - Panama City Tocumen Intl or Columbia Metropolitan - Panama City Tocumen Intl.

  • Can I find deals for flights from South Carolina to Panama City that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama City.

  • Can I find deals for business class flights from South Carolina to Panama City?

    Yes. Cheapflights offers flight deals from South Carolina to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama City?

    Currently, March is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $487). Flying from South Carolina to Panama City in December is currently the most expensive (average of $861). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Panama City

Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$235Average$605FlexibilityNo cancel feeOn-time69%
DeltaCheapest$396Average$568FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$399Average$633FlexibilityNo cancel feeOn-time71%

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