$257+ Cheap flights from South Carolina to Panama City (PTY)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/1. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Oct 10 — Oct 171
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Panama City
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Cheapest flights from South Carolina to Panama CityExplore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:45 am -
1 stop7h 14m
Mon 11/23:24 pm -
1 stop18h 46m
Deal found 9/6![Delta logo]()
$581
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:40 am -
1 stop8h 05m
Mon 12/710:00 am -
1 stop11h 06m
Deal found 9/7![United Airlines logo]()
$589
This Expedia deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/122:20 pm -
2 stops35h 50m
Sun 11/153:55 pm -
2 stops21h 30m
Deal found 9/9![Multiple Airlines logo]()
$590
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:22 pm -
1 stop30h 40m
Mon 11/1610:00 am -
1 stop11h 41m
Deal found 9/8![United Airlines logo]()
$597
This Expedia deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/312:42 pm -
2 stops13h 28m
Mon 12/73:55 pm -
2 stops19h 57m
Deal found 9/5![Multiple Airlines logo]()
$600
This Travelocity deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/262:05 pm -
2 stops21h 25m
Sat 10/243:50 pm -
2 stops20h 35m
Deal found 9/5![Multiple Airlines logo]()
$600
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:50 am -
1 stop14h 12m
Mon 11/1610:00 am -
1 stop13h 29m
Deal found 9/9![United Airlines logo]()
$601
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:30 pm -
2 stops24h 32m
Wed 2/38:55 am -
2 stops25h 42m
Deal found 9/8![United Airlines logo]()
$605
This oojo deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/12:28 pm -
2 stops21h 02m
Sun 10/43:50 pm -
2 stops20h 17m
Deal found 9/9![Multiple Airlines logo]()
$606
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am -
1 stop13h 02m
Mon 12/710:00 am -
1 stop13h 59m
Deal found 9/5![United Airlines logo]()
$607
This Expedia deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1411:21 am -
2 stops47h 14m
Sat 1/305:30 am -
2 stops13h 58m
Deal found 9/5![Multiple Airlines logo]()
$607
This Orbitz deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:08 am -
2 stops24h 22m
Sun 9/273:50 pm -
2 stops17h 27m
Deal found 9/9![Multiple Airlines logo]()
$608
Best flights from South Carolina to Panama CityDiscover carefully curated flight deals from South Carolina to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from South Carolina to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This Expedia deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/310:10 am -
2 stops16h 00m
Tue 2/93:55 pm -
2 stops17h 25m
Deal found 9/8![Multiple Airlines logo]()
$582
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:55 pm -
2 stops24h 07m
Mon 11/164:41 pm -
1 stop18h 08m
Deal found 9/8![United Airlines logo]()
$593
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/85:20 am -
1 stop8h 43m
Wed 12/163:29 pm -
1 stop8h 19m
Deal found 9/7![Delta logo]()
$631
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
1 stop8h 02m
Fri 10/302:02 pm -
2 stops25h 33m
Deal found 9/8![American Airlines logo]()
$659
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/17:00 pm -
2 stops19h 45m
Mon 3/811:35 am -
2 stops22h 28m
Deal found 9/7![United Airlines logo]()
$593
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:52 am -
1 stop9h 10m
Mon 11/1610:00 am -
2 stops23h 46m
Deal found 9/9![United Airlines logo]()
$593
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/13:36 pm -
2 stops22h 00m
Sun 2/284:04 pm -
2 stops20h 08m
Deal found 9/6![American Airlines logo]()
$663
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/286:00 am -
1 stop7h 55m
Thu 2/43:20 pm -
1 stop8h 15m
Deal found 9/7![Delta logo]()
$678
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:50 am -
1 stop14h 12m
Mon 11/1610:00 am -
1 stop13h 29m
Deal found 9/9![United Airlines logo]()
$601
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:00 am -
1 stop8h 02m
Fri 10/232:02 pm -
1 stop7h 50m
Deal found 9/6![American Airlines logo]()
$673
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:47 pm -
1 stop22h 15m
Mon 11/163:29 pm -
1 stop21h 45m
Deal found 9/9![Delta logo]()
$725
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/256:15 am -
2 stops13h 47m
Wed 2/34:41 pm -
2 stops24h 15m
Deal found 9/6![United Airlines logo]()
$605
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/83:53 pm -
2 stops22h 20m
Wed 12/163:13 pm -
2 stops26h 37m
Deal found 9/7![American Airlines logo]()
$714
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/36:30 am -
1 stop10h 42m
Tue 2/910:00 am -
1 stop13h 19m
Deal found 9/8![United Airlines logo]()
$607
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:40 am -
1 stop8h 19m
Sun 11/13:24 pm -
1 stop8h 23m
Deal found 9/9![Delta logo]()
$746
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:00 am -
1 stop8h 02m
Mon 10/122:02 pm -
1 stop7h 50m
Deal found 9/8![American Airlines logo]()
$716
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am -
1 stop13h 02m
Tue 12/88:55 am -
1 stop12h 59m
Deal found 9/5![United Airlines logo]()
$607
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1310:00 am -
1 stop28h 02m
Sun 11/153:29 pm -
1 stop26h 58m
Deal found 9/9![Delta logo]()
$781
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am -
1 stop13h 02m
Mon 12/710:00 am -
1 stop13h 59m
Deal found 9/5![United Airlines logo]()
$607
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:16 pm -
2 stops18h 46m
Fri 10/162:02 pm -
2 stops19h 31m
Deal found 9/9![American Airlines logo]()
$762
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/35:20 am -
1 stop8h 43m
Wed 12/163:29 pm -
1 stop8h 19m
Deal found 9/7![Delta logo]()
$791
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:56 pm -
2 stops24h 06m
Mon 12/710:00 am -
1 stop13h 59m
Deal found 9/5![United Airlines logo]()
$611
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:00 am -
1 stop14h 02m
Mon 11/1610:00 am -
1 stop11h 41m
Deal found 9/9![United Airlines logo]()
$619
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:12 pm -
1 stop18h 50m
Mon 11/163:29 pm -
1 stop8h 18m
Deal found 9/9![Delta logo]()
$858
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:00 am -
1 stop14h 02m
Sat 12/58:55 am -
1 stop12h 56m
Deal found 9/5![United Airlines logo]()
$619
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2712:41 pm -
2 stops25h 10m
Sat 1/94:55 pm -
2 stops22h 22m
Deal found 9/9![American Airlines logo]()
$973
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:40 am -
1 stop8h 05m
Tue 11/104:41 pm -
1 stop18h 08m
Deal found 9/6![United Airlines logo]()
$619
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:30 am -
1 stop8h 32m
Sun 11/153:29 pm -
1 stop8h 18m
Deal found 9/9![Delta logo]()
$1,010
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:25 am -
1 stop14h 06m
Wed 10/287:55 am -
1 stop13h 04m
Deal found 9/6![United Airlines logo]()
$629
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:00 am -
1 stop13h 31m
Thu 10/297:55 am -
2 stops26h 24m
Deal found 9/7![United Airlines logo]()
$633
Last-minute flights from South Carolina to Panama CityDiscover last-minute flight deals from South Carolina to Panama City. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Panama City. Data last updated September 10, 2026 and is based on user searches.
This Orbitz deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:08 am -
2 stops24h 22m
Sun 9/273:50 pm -
2 stops17h 27m
Deal found 9/9![Multiple Airlines logo]()
$608
This Travelocity deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/262:05 pm -
2 stops21h 25m
Sat 10/243:50 pm -
2 stops20h 35m
Deal found 9/5![Multiple Airlines logo]()
$600
This Orbitz deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/282:05 pm -
2 stops21h 25m
Thu 10/13:50 pm -
2 stops20h 37m
Deal found 9/7![Multiple Airlines logo]()
$638
This oojo deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/12:28 pm -
2 stops21h 02m
Sun 10/43:50 pm -
2 stops20h 17m
Deal found 9/9![Multiple Airlines logo]()
$606
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:30 am -
1 stop7h 29m
Wed 10/282:24 pm -
1 stop8h 35m
Deal found 9/5![Delta logo]()
$629
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:25 am -
1 stop14h 06m
Wed 10/287:55 am -
1 stop13h 04m
Deal found 9/6![United Airlines logo]()
$629
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:50 pm -
2 stops25h 41m
Wed 10/289:30 am -
1 stop13h 29m
Deal found 9/5![United Airlines logo]()
$633
This Expedia deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:42 pm -
2 stops30h 13m
Thu 10/295:30 am -
2 stops26h 14m
Deal found 9/7![Multiple Airlines logo]()
$625
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:45 am -
1 stop7h 14m
Mon 11/23:24 pm -
1 stop18h 46m
Deal found 9/6![Delta logo]()
$581
This Expedia deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:35 pm -
2 stops30h 35m
Sun 11/15:30 am -
2 stops27h 14m
Deal found 9/8![Multiple Airlines logo]()
$617
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:40 am -
1 stop8h 05m
Mon 11/910:00 am -
1 stop11h 41m
Deal found 9/7![United Airlines logo]()
$619
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:00 am -
1 stop8h 02m
Sun 11/13:13 pm -
1 stop16h 59m
Deal found 9/9![American Airlines logo]()
$624
One-way flights from South Carolina to Panama CitySearch for one-way flight options from South Carolina to Panama City. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
Search for one-way flight options from South Carolina to Panama City. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:00 am -
1 stop14h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$257
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/49:30 pm -
1 stop16h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$262
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:50 pm -
2 stops24h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![United Airlines logo]()
$263
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/206:00 am -
1 stop7h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$267
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/215:06 pm -
2 stops20h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![American Airlines logo]()
$268
This Expedia deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:42 pm -
2 stops14h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$276
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/316:19 pm -
1 stop25h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$276
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/113:36 pm -
2 stops22h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![American Airlines logo]()
$286
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:40 am -
1 stop12h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$292
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
1 stop8h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![American Airlines logo]()
$293
This Orbitz deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/242:05 pm -
2 stops21h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$297
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/47:47 pm -
2 stops24h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$297
Find flight deals from South Carolina to Panama City
Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated September 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $581 (Delta) |
One-way from | $257 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlottePanama City
CLT Charlotte Douglas - PTY Panama City Tocumen Intl
CLTPTY
Charlotte Douglas
Wed 11/4
6:00 am-8:02 pm
1 stop14h 02m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$262
CharlottePanama City
CLT Charlotte Douglas - PTY Panama City Tocumen Intl
CLTPTY
Charlotte Douglas
Wed 12/2
7:50 pm-8:02 pm
2 stops24h 12m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$263
CharlestonPanama City
CHS Charleston - PTY Panama City Tocumen Intl
CHSPTY
Charleston
Fri 10/23
8:42 pm-10:30 am
2 stops14h 48m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$276
Myrtle BeachPanama City
MYR Myrtle Beach Intl - PTY Panama City Tocumen Intl
MYRPTY
Myrtle Beach Intl
Mon 1/11
1:56 pm-1:36 pm
2 stops23h 40m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$286
CharlottePanama City
CLT Charlotte Douglas - PTY Panama City Tocumen Intl
CLTPTY
Charlotte Douglas
Sun 11/15
6:40 am-7:38 pm
1 stop12h 58m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$292
SavannahPanama City
SAV Savannah/Hilton Head - PTY Panama City Tocumen Intl
SAVPTY
Savannah/Hilton Head
Thu 9/24
2:05 pm-10:30 am
2 stops21h 25m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$297
CharlottePanama City
CLT Charlotte Douglas - PTY Panama City Tocumen Intl
CLTPTY
Charlotte Douglas
Thu 2/4
7:47 pm-8:02 pm
2 stops24h 15m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$297
Myrtle BeachPanama City
MYR Myrtle Beach Intl - PTY Panama City Tocumen Intl
MYRPTY
Myrtle Beach Intl
Mon 1/11
6:00 am-1:55 pm
1 stop7h 55m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$330
CharlestonPanama City
CHS Charleston - PTY Panama City Tocumen Intl
CHSPTY
Charleston
Sat 12/12
7:40 am-10:35 am
2 stops26h 55m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$330
CharlottePanama City
CLT Charlotte Douglas - PTY Panama City Tocumen Intl
CLTPTY
Charlotte Douglas
Wed 1/20
10:23 am-2:10 am
2 stops15h 47m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$339
Showing 1-10 of 56 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
CLT-PTY
MYR-PTY
CHS-PTY
SAV-PTY
AGS-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Panama City
USSC-PTY
CLT-PTY
MYR-PTY
CHS-PTY
SAV-PTY
What is the cheapest month to book a flight from South Carolina to Panama City?
Currently, March is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $487). Flying from South Carolina to Panama City in December is currently the most expensive (average of $803). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from South Carolina to Panama City?
Airfare is below average for this route at the moment.
South Carolina to Panama City flights typically cost between $608 and $845 in January.The cheapest round-trip price found within the last 5 days was $582 on Multiple Airlines (Jan 14-Jan 19).
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Panama City flight routes
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Alternative routes for South Carolina to Panama City
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Panama City by cabin class
Find flights from South Carolina to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Panama City flights
Browse other South Carolina and Panama City flight options. Last updated on September 10, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
South Carolina to Panama City flights
Consider these flights traveling from South Carolina to Panama City.
Top 3 airlines flying from South Carolina to Panama City
Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$299 | Average$639 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$369 | Average$630 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$399 | Average$696 | FlexibilityNo cancel fee | On-time71% |