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Panama City

$214+ Cheap flights from South Carolina to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/31. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
jul. 8 — jul. 151
mar. 7/8
mar. 7/15
1 adult, Economy
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Cheap flight deals from South Carolina to Panama City

Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated julio 3, 2025.

Round-trip from

$327
(American Airlines)

One-way from

$214
(Kiwi.com)

Popular in

February

Cheapest in

August

Average price

$631
From South Carolina to Panama City Tocumen Intl
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One-way flight from South Carolina to Panama City Tocumen Intl
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Highest demand for flights based on searches. 7% potential increase in price ($49 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from South Carolina to Panama City

Cheapest flights from South Carolina to Panama City
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 3, 2025.

This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/156:00 amCHS - PTY
1 stop9h 00mAmerican Airlines
sáb. 10/253:19 pmPTY - CHS
1 stop7h 40mAmerican Airlines
Deal found 7/1$327
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/26:20 amCHS - PTY
1 stop7h 30mDelta
lun. 9/82:05 pmPTY - CHS
1 stop8h 46mDelta
Deal found 7/1$369
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/297:00 amCHS - PTY
1 stop12h 37mUnited Airlines
mar. 8/53:30 pmPTY - CHS
1 stop30h 15mUnited Airlines
Deal found 7/1$378
This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/285:45 amGSP - PTY
1 stop8h 02mDelta
mié. 11/53:12 pmPTY - GSP
1 stop8h 25mDelta
Deal found 7/2$391
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/137:24 pmGSP - PTY
2 stops20h 06mAmerican Airlines
mar. 8/193:30 pmPTY - GSP
2 stops18h 22mAmerican Airlines
Deal found 7/2$396
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/135:34 pmGSP - PTY
1 stop26h 03mUnited Airlines
mar. 8/193:30 pmPTY - GSP
1 stop29h 30mUnited Airlines
Deal found 7/1$408
This Avianca Connect deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/87:08 amCLT - PTY
2 stops18h 37mMultiple Airlines
vie. 9/123:25 amPTY - CLT
2 stops17h 34mMultiple Airlines
Deal found 7/1$448
This United Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/277:00 amSAV - PTY
1 stop8h 14mUnited Airlines
mié. 9/1010:00 amPTY - SAV
1 stop10h 59mUnited Airlines
Deal found 7/3$467
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/2810:25 pmCLT - PTY
1 stop17h 05mAmerican Airlines
mar. 9/23:30 pmPTY - CLT
1 stop7h 29mAmerican Airlines
Deal found 7/2$467
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/277:28 pmSAV - PTY
2 stops20h 02mAmerican Airlines
mié. 9/101:45 pmPTY - SAV
2 stops19h 22mAmerican Airlines
Deal found 7/3$472
This Delta deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/235:30 amCLT - PTY
1 stop8h 17mDelta
dom. 10/262:12 pmPTY - CLT
1 stop8h 42mDelta
Deal found 7/3$487
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/256:15 amCAE - PTY
2 stops9h 15mAmerican Airlines
mar. 8/263:30 pmPTY - CAE
2 stops17h 30mAmerican Airlines
Deal found 7/2$492

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 3, 2025.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

South Carolina

Fly to

Panama City

Route

Depart

Return

Price

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mié. 10/15

6:00 am-2:00 pm

1 stop9h 00m

Panama City Tocumen Intl

sáb. 10/25

3:19 pm-11:59 pm

1 stop7h 40m

$327

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mar. 9/2

6:20 am-12:50 pm

1 stop7h 30m

Panama City Tocumen Intl

lun. 9/8

2:05 pm-11:51 pm

1 stop8h 46m

$369

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mar. 7/29

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

mar. 8/5

3:30 pm-10:45 pm

1 stop30h 15m

$378

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 8/13

6:30 am-2:30 pm

1 stop9h 00m

Panama City Tocumen Intl

mar. 8/19

3:30 pm-11:35 pm

1 stop7h 05m

$391

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mié. 8/13

5:34 pm-6:37 pm

1 stop26h 03m

Panama City Tocumen Intl

mar. 8/19

3:30 pm-10:00 pm

1 stop29h 30m

$408

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

vie. 9/19

5:30 am-12:55 pm

1 stop8h 25m

Panama City Tocumen Intl

sáb. 9/27

2:10 pm-11:34 pm

1 stop8h 24m

$427

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

lun. 9/8

7:08 am-12:45 am

2 stops18h 37m

Panama City Tocumen Intl

vie. 9/12

3:25 am-9:59 pm

2 stops17h 34m

$448

SavannahPanama City

SAV - PTY

SAVPTY

Savannah/Hilton Head

mié. 8/27

7:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

mié. 9/10

10:00 am-9:59 pm

1 stop10h 59m

$467

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

jue. 8/28

10:25 pm-2:30 pm

1 stop17h 05m

Panama City Tocumen Intl

mar. 9/2

3:30 pm-11:59 pm

1 stop7h 29m

$467

SavannahPanama City

SAV - PTY

SAVPTY

Savannah/Hilton Head

mié. 8/27

7:28 pm-2:30 pm

2 stops20h 02m

Panama City Tocumen Intl

mié. 9/10

1:45 pm-10:07 am

2 stops19h 22m

$472

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Showing 1-10 of 35 results
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Best time to book a flight from South Carolina to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama City

What is the cheapest month to book a flight from South Carolina to Panama City?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $478). Flying from South Carolina to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to PTY?

Find hourly flight availability from South Carolina to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 3, 2025.

When flying from South Carolina to Panama City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated julio 3, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from South Carolina to Panama City have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,982 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,861 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Avianca
6.7
Okay
2,363 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from South Carolina?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Panama City from South Carolina.

  • What are the cheapest airlines to fly from South Carolina to Panama City one-way?

    The cheapest airlines for a one-way flight from South Carolina to Panama City are United Airlines ($221), American Airlines ($227), and Delta ($331).

  • What are the most popular routes from South Carolina to Panama City?

    The most popular route from South Carolina to Panama City is Charlotte Douglas - Panama City Tocumen Intl. You may also consider Columbia Metropolitan - Panama City Tocumen Intl or Greenville - Panama City Tocumen Intl.

  • Can I find deals for flights from South Carolina to Panama City that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama City.

  • Can I find deals for business class flights from South Carolina to Panama City?

    Yes. Cheapflights offers flight deals from South Carolina to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama City?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $478). Flying from South Carolina to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Panama City

Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$268Average$422FlexibilityNo cancel feeOn-time69%
DeltaCheapest$331Average$586FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$352Average$560FlexibilityNo cancel feeOn-time71%

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