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Panama City

$216+ Cheap flights from South Carolina to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Jun 29 — Jul 61
Mon 6/29
Mon 7/6
1 adult, Economy
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Cheap flight deals from South Carolina to Panama City

Cheapest flights from South Carolina to Panama City
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 30, 2026.

This United Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:00 am
CHS
-
PTY
1 stop13h 31m
United Airlines
Thu 9/109:45 am
PTY
-
CHS
1 stop13h 14m
United Airlines
Deal found 5/27$497
This United Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:10 am
CHS
-
PTY
1 stop17h 54m
United Airlines
Mon 9/710:55 pm
PTY
-
CHS
2 stops21h 39m
United Airlines
Deal found 5/28$501
This Kiwi.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:48 pm
CLT
-
PTY
1 stop14h 18m
Multiple Airlines
Fri 7/245:30 am
PTY
-
CLT
2 stops10h 42m
Multiple Airlines
Deal found 5/25$508
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/208:13 pm
CHS
-
PTY
1 stop17h 01m
American Airlines
Fri 7/241:14 pm
PTY
-
CHS
2 stops20h 02m
American Airlines
Deal found 5/26$510
This United Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/133:34 pm
CHS
-
PTY
1 stop13h 30m
United Airlines
Mon 7/2010:00 am
PTY
-
CHS
1 stop11h 15m
United Airlines
Deal found 5/29$514
This Kiwi.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:48 pm
CLT
-
PTY
1 stop14h 42m
Multiple Airlines
Tue 7/283:10 pm
PTY
-
CLT
2 stops25h 02m
Multiple Airlines
Deal found 5/25$516
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:48 pm
CLT
-
PTY
1 stop14h 42m
Multiple Airlines
Thu 7/235:30 am
PTY
-
CLT
2 stops10h 42m
Multiple Airlines
Deal found 5/27$518
This United Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/277:00 am
CLT
-
PTY
1 stop13h 31m
United Airlines
Wed 7/299:45 am
PTY
-
CLT
1 stop9h 37m
United Airlines
Deal found 5/27$519
This KAYAK deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:00 am
CHS
-
PTY
1 stop13h 31m
Copa Airlines
Mon 9/73:30 pm
PTY
-
CHS
2 stops18h 11m
Copa Airlines
Deal found 5/28$520
This United Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:55 pm
CLT
-
PTY
2 stops24h 36m
United Airlines
Thu 8/273:30 pm
PTY
-
CLT
2 stops21h 35m
United Airlines
Deal found 5/27$523
This Delta deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:55 am
GSP
-
PTY
1 stop7h 00m
Delta
Tue 8/252:20 pm
PTY
-
GSP
1 stop7h 39m
Delta
Deal found 5/29$527
This United Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:00 am
CLT
-
PTY
1 stop22h 04m
United Airlines
Tue 7/289:45 am
PTY
-
CLT
1 stop10h 08m
United Airlines
Deal found 5/27$527

Find flight deals from South Carolina to Panama City

Keep the following information in mind while searching for South Carolina to Panama City flight deals. Data was last updated May 30, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$497
(United Airlines)

One-way from

$216
(Delta)
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
Search Deals
From South Carolina to Panama City Tocumen Intl
Search Deals
One-way flight from South Carolina to Panama City Tocumen Intl
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 30, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 9/15

7:00 am-7:31 pm

1 stop13h 31m

Panama City Tocumen Intl

Wed 10/7

10:00 am-10:12 pm

1 stop11h 12m

$497

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Wed 9/16

4:12 pm-12:15 pm

2 stops21h 03m

Panama City Tocumen Intl

Wed 10/7

3:35 pm-5:29 pm

2 stops24h 54m

$501

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Wed 9/2

11:10 am-4:04 am

1 stop17h 54m

Panama City Tocumen Intl

Mon 9/7

3:30 pm-10:41 am

2 stops18h 11m

$501

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Mon 7/13

3:34 pm-4:04 am

1 stop13h 30m

Panama City Tocumen Intl

Mon 7/20

10:00 am-10:15 pm

1 stop11h 15m

$514

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 8/3

7:09 am-4:12 pm

1 stop10h 03m

Panama City Tocumen Intl

Tue 8/11

3:30 pm-10:08 am

2 stops17h 38m

$523

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 8/24

6:00 am-7:31 pm

2 stops14h 31m

Panama City Tocumen Intl

Thu 8/27

3:30 pm-10:08 am

2 stops17h 38m

$523
Quickest round-trip

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 8/11

6:55 am-12:55 pm

1 stop7h 00m

Panama City Tocumen Intl

Wed 8/19

2:20 pm-10:59 pm

1 stop7h 39m

$527

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 9/15

5:45 am-12:56 pm

1 stop8h 11m

Panama City Tocumen Intl

Thu 10/15

2:21 pm-11:37 pm

1 stop8h 16m

$527

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 8/11

8:29 pm-4:04 am

1 stop8h 35m

Panama City Tocumen Intl

Wed 8/19

3:30 pm-9:35 am

2 stops17h 05m

$531

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Mon 8/24

7:00 am-7:31 pm

1 stop13h 31m

Panama City Tocumen Intl

Tue 8/25

10:55 pm-5:02 pm

2 stops17h 07m

$531

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/28

Showing 1-10 of 52 resultsSorted by cheapest first
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Best time to book a flight from South Carolina to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Panama City

What is the cheapest month to book a flight from South Carolina to Panama City?

Currently, July is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $172). Flying from South Carolina to Panama City in December is currently the most expensive (average of $496). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from South Carolina to Panama City?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from South Carolina?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Panama City from South Carolina.

  • How long is the flight from South Carolina to Panama City?

    A quick flight from South Carolina to Panama City can take about 7h. United Airlines provides one of the quickest options available for as low as $527. There are 1792 mi between South Carolina and Panama City. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from South Carolina to Panama City?

    The most popular route from South Carolina to Panama City is Charlotte Douglas - Panama City Tocumen Intl. You may also consider Columbia Metropolitan - Panama City Tocumen Intl or Greenville - Panama City Tocumen Intl.

  • Can I find deals for flights from South Carolina to Panama City that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama City.

  • Can I find deals for business class flights from South Carolina to Panama City?

    Yes. Cheapflights offers flight deals from South Carolina to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama City?

    Currently, July is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $172). Flying from South Carolina to Panama City in December is currently the most expensive (average of $496). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Panama City

Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 30, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$309Average$557FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$389Average$608FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$389Average$511FlexibilityNo cancel feeOn-time69%

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