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$333+ Cheap flights from Ohio to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/7. Fares are subject to change and may not be available on all flights or dates of travel.
CVG — FLO
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
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Cheap flight deals from Ohio to Florence

Cheapest flights from Ohio to Florence
Explore the most affordable flight options available from Ohio to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/174:47 pmDTW - FLO
1 stop6h 06mAmerican Airlines
Sun 12/215:15 amFLO - DTW
1 stop5h 56mAmerican Airlines
Deal found 12/2$362
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:23 amCMH - FLO
1 stop4h 03mAmerican Airlines
Sun 1/46:30 pmFLO - CMH
1 stop6h 02mAmerican Airlines
Deal found 12/2$517
This American Airlines deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:38 amPIT - FLO
1 stop5h 48mAmerican Airlines
Tue 12/235:15 amFLO - PIT
1 stop4h 24mAmerican Airlines
Deal found 12/4$519
This American Airlines deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:46 pmCAK - FLO
1 stop4h 29mAmerican Airlines
Sun 12/286:30 pmFLO - CAK
1 stop3h 42mAmerican Airlines
Deal found 12/4$520
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:36 amCMH - FLO
1 stop6h 06mAmerican Airlines
Sat 1/35:15 amFLO - CMH
2 stops6h 54mAmerican Airlines
Deal found 12/2$522

Find flight deals from Ohio to Florence

Keep the following information in mind while searching for Ohio to Florence flight deals. Data was last updated December 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$333
(American Airlines)
Provider with most accurate pricing for Cleveland Hopkins Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Cleveland Hopkins Intl-Florence flights.
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From Ohio to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Ohio to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Ohio to Florence that are best for you.

Fly from

Ohio

Fly to

Florence

Route

Depart

Return

Price

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 1/7

11:30 am-5:09 pm

1 stop5h 39m

Florence

Sat 1/10

5:36 pm-11:56 pm

1 stop6h 20m

$333

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 12/17

4:47 pm-10:53 pm

1 stop6h 06m

Florence

Sun 12/21

5:15 am-11:11 am

1 stop5h 56m

$362

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Tue 1/27

6:00 am-5:09 pm

2 stops11h 09m

Florence

Sat 1/31

6:15 am-9:30 pm

2 stops15h 15m

$418

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Fri 1/2

6:00 am-6:05 pm

2 stops12h 05m

Florence

Sun 1/4

5:15 am-3:14 pm

2 stops9h 59m

$457

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Sat 2/14

5:14 pm-11:58 pm

1 stop6h 44m

Florence

Tue 2/17

5:58 pm-7:33 am

2 stops13h 35m

$462

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Sun 2/1

11:00 am-10:43 pm

2 stops11h 43m

Florence

Wed 2/4

6:15 am-7:02 pm

2 stops12h 47m

$466

CincinnatiFlorence

CVG - FLO

CVGFLO

Cincinnati Cinci./N. Kentucky

Tue 1/27

5:08 pm-10:43 pm

1 stop5h 35m

Florence

Sat 1/31

6:15 am-12:37 pm

1 stop6h 22m

$475

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Mon 12/29

8:23 am-12:26 pm

1 stop4h 03m

Florence

Sun 1/4

6:30 pm-12:32 am

1 stop6h 02m

$517

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Fri 12/19

6:38 am-12:26 pm

1 stop5h 48m

Florence

Tue 12/23

5:15 am-9:39 am

1 stop4h 24m

$519

AkronFlorence

CAK - FLO

CAKFLO

Akron/Canton

Tue 12/23

7:46 pm-12:15 am

1 stop4h 29m

Florence

Sun 12/28

6:30 pm-10:12 pm

1 stop3h 42m

$520

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/1

Showing 1-10 of 12 results
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Best time to book a flight from Ohio to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Ohio with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Ohio to Florence

What is the cheapest month to book a flight from Ohio to Florence, South Carolina?

Currently, October is the cheapest month in which you can book a flight from Ohio to Florence, South Carolina (average of $41). Flying from Ohio to Florence, South Carolina in November is currently the most expensive (average of $86). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Ohio to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Ohio?

    If you book a flight to Florence from Ohio, you will be flying to Florence, which is the city’s only airport. Florence (FLO) is located 2.3 mi from the center of Florence.

  • How long is the flight from Ohio to Florence, South Carolina?

    Airlines like American Airlines fly from Ohio to Florence, South Carolina in about 5h 39m. The time it takes to get you to your destination can typically vary by up to . The distance between Ohio and Florence, South Carolina is about 589 mi.

  • What are the most popular routes from Ohio to Florence, South Carolina?

    While some choose either Columbus - Florence or Akron/Canton - Florence, Cleveland Hopkins Intl - Florence is the most popular route from Ohio to Florence, South Carolina.

  • Can I find deals for flights from Ohio to Florence that include hotel bookings?

    Yes. In addition to deals on Ohio to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Ohio to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Ohio to Florence.

  • Can I find deals for business class flights from Ohio to Florence?

    Yes. Cheapflights offers flight deals from Ohio to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Ohio to Florence, South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Ohio to Florence, South Carolina (average of $41). Flying from Ohio to Florence, South Carolina in November is currently the most expensive (average of $86). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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