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Florence

$304+ Cheap flights from Ohio to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/19. Fares are subject to change and may not be available on all flights or dates of travel.
CVG — FLO
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Ohio to Florence

Cheapest flights from Ohio to Florence
Explore the most affordable flight options available from Ohio to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/196:15 am
DTW
-
FLO
2 stops11h 35m
American Airlines
Tue 2/246:15 am
FLO
-
DTW
1 stop6h 01m
American Airlines
Deal found 1/26$304
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2911:30 am
DTW
-
FLO
1 stop5h 39m
American Airlines
Sat 1/315:36 pm
FLO
-
DTW
1 stop6h 20m
American Airlines
Deal found 1/26$382
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/1011:54 am
PIT
-
FLO
2 stops10h 49m
American Airlines
Sat 2/145:16 am
FLO
-
PIT
2 stops13h 52m
American Airlines
Deal found 1/26$391
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/3011:30 am
DTW
-
FLO
1 stop5h 39m
American Airlines
Sun 2/15:36 pm
FLO
-
DTW
1 stop4h 22m
American Airlines
Deal found 1/26$409
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/106:00 am
CLE
-
FLO
2 stops11h 09m
American Airlines
Sat 2/145:16 am
FLO
-
CLE
2 stops10h 11m
American Airlines
Deal found 1/25$438
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/211:07 am
PIT
-
FLO
2 stops12h 55m
American Airlines
Wed 9/95:31 am
FLO
-
PIT
2 stops12h 16m
American Airlines
Deal found 1/26$460
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/1011:40 am
CMH
-
FLO
2 stops11h 03m
American Airlines
Sat 2/145:16 am
FLO
-
CMH
2 stops12h 59m
American Airlines
Deal found 1/26$468
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:07 am
PIT
-
FLO
2 stops17h 55m
American Airlines
Sat 9/52:34 pm
FLO
-
PIT
1 stop3h 27m
American Airlines
Deal found 1/26$474
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/317:00 am
PIT
-
FLO
2 stops7h 09m
American Airlines
Wed 9/95:31 am
FLO
-
PIT
2 stops9h 09m
American Airlines
Deal found 1/26$486
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:01 am
PIT
-
FLO
2 stops14h 01m
American Airlines
Sat 9/55:14 am
FLO
-
PIT
2 stops16h 34m
American Airlines
Deal found 1/26$488
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:54 pm
CAK
-
FLO
1 stop5h 08m
American Airlines
Wed 9/911:20 am
FLO
-
CAK
1 stop6h 39m
American Airlines
Deal found 1/26$495
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:51 pm
DAY
-
FLO
1 stop6h 05m
American Airlines
Thu 7/302:36 pm
FLO
-
DAY
1 stop6h 07m
American Airlines
Deal found 1/26$495

Find flight deals from Ohio to Florence

Keep the following information in mind while searching for Ohio to Florence flight deals. Data was last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$304
(American Airlines)
Provider with most accurate pricing for Cleveland Hopkins Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Cleveland Hopkins Intl-Florence flights.
Search Deals
From Ohio to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Ohio to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Ohio to Florence that are best for you.

Fly from

Ohio

Fly to

Florence

Route

Depart

Return

Price

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 2/19

6:15 am-5:50 pm

2 stops11h 35m

Florence

Tue 2/24

6:15 am-12:16 pm

1 stop6h 01m

$304

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Tue 2/10

11:54 am-10:43 pm

2 stops10h 49m

Florence

Sat 2/14

5:16 am-7:08 pm

2 stops13h 52m

$391

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 2/6

6:17 pm-10:43 pm

1 stop4h 26m

Florence

Sun 2/8

5:36 pm-9:58 pm

1 stop4h 22m

$409

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 1/30

11:30 am-5:09 pm

1 stop5h 39m

Florence

Sun 2/1

5:36 pm-9:58 pm

1 stop4h 22m

$409

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Tue 2/10

6:00 am-5:09 pm

2 stops11h 09m

Florence

Sat 2/14

5:16 am-3:27 pm

2 stops10h 11m

$438

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Tue 2/10

11:40 am-10:43 pm

2 stops11h 03m

Florence

Sat 2/14

5:16 am-6:15 pm

2 stops12h 59m

$468

DaytonFlorence

DAY - FLO

DAYFLO

Dayton

Tue 6/30

5:51 pm-11:56 pm

1 stop6h 05m

Florence

Thu 7/30

2:36 pm-8:43 pm

1 stop6h 07m

$495

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Fri 4/10

7:39 pm-11:53 pm

1 stop4h 14m

Florence

Mon 4/13

5:24 am-9:43 am

1 stop4h 19m

$501

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 4/9

6:00 am-3:50 pm

2 stops9h 50m

Florence

Sun 4/12

5:24 am-9:15 am

1 stop3h 51m

$520

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Fri 3/13

6:55 pm-11:57 pm

1 stop5h 02m

Florence

Sun 3/15

6:20 pm-12:34 am

1 stop6h 14m

$545

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Showing 1-10 of 15 results
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Best time to book a flight from Ohio to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Ohio with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Ohio to Florence

What is the cheapest month to book a flight from Ohio to Florence, South Carolina?

Currently, October is the cheapest month in which you can book a flight from Ohio to Florence, South Carolina (average of $41). Flying from Ohio to Florence, South Carolina in November is currently the most expensive (average of $86). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Ohio to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Ohio?

    If you book a flight to Florence from Ohio, you will be flying to Florence, which is the city’s only airport. Florence (FLO) is located 2.3 mi from the center of Florence.

  • How long is the flight from Ohio to Florence, South Carolina?

    Airlines like American Airlines fly from Ohio to Florence, South Carolina in about 11h 35m. The time it takes to get you to your destination can typically vary by up to . The distance between Ohio and Florence, South Carolina is about 589 mi.

  • What are the most popular routes from Ohio to Florence, South Carolina?

    While some choose either Detroit Metropolitan Wayne County - Florence or Columbus - Florence, Cleveland Hopkins Intl - Florence is the most popular route from Ohio to Florence, South Carolina.

  • Can I find deals for flights from Ohio to Florence that include hotel bookings?

    Yes. In addition to deals on Ohio to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Ohio to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Ohio to Florence.

  • Can I find deals for business class flights from Ohio to Florence?

    Yes. Cheapflights offers flight deals from Ohio to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Ohio to Florence, South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Ohio to Florence, South Carolina (average of $41). Flying from Ohio to Florence, South Carolina in November is currently the most expensive (average of $86). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Alternative routes for Ohio to Florence

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Ohio to Florence

Discover the top airline that operate flights from Ohio to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$377Average$490FlexibilityNo cancel feeOn-time71%

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