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Florence

$286+ Cheap flights from Ohio to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.
CVG — FLO
Nov 12 — Nov 191
Wed 11/12
Wed 11/19
1 adult, Economy
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Find flight deals from Ohio to Florence

Cheapest flights from Ohio to Florence
Explore the most affordable flight options available from Ohio to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 13, 2025.

This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:01 amDTW - FLO
1 stop6h 25mAmerican Airlines
Tue 12/306:30 pmFLO - DTW
1 stop6h 14mAmerican Airlines
Deal found 10/11$421
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:00 amCVG - FLO
1 stop3h 50mAmerican Airlines
Sat 12/1311:16 amFLO - CVG
1 stop5h 59mAmerican Airlines
Deal found 10/12$475
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:00 amDAY - FLO
1 stop3h 50mAmerican Airlines
Sat 12/136:31 pmFLO - DAY
1 stop4h 11mAmerican Airlines
Deal found 10/12$475
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3112:57 pmDTW - FLO
1 stop5h 57mAmerican Airlines
Fri 11/710:29 amFLO - DTW
2 stops11h 47mAmerican Airlines
Deal found 10/11$494
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/311:12 pmDTW - FLO
2 stops21h 34mAmerican Airlines
Sat 11/85:15 amFLO - DTW
2 stops12h 26mAmerican Airlines
Deal found 10/11$497
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:40 pmDTW - FLO
1 stop4h 33mAmerican Airlines
Thu 11/65:15 amFLO - DTW
1 stop4h 33mAmerican Airlines
Deal found 10/11$499
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:00 amDTW - FLO
1 stop4h 46mAmerican Airlines
Sat 11/85:15 amFLO - DTW
1 stop4h 33mAmerican Airlines
Deal found 10/11$511
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3112:57 pmDTW - FLO
1 stop5h 57mAmerican Airlines
Sun 11/95:15 amFLO - DTW
1 stop5h 58mAmerican Airlines
Deal found 10/11$520
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/265:51 pmPIT - FLO
1 stop5h 50mAmerican Airlines
Sun 11/305:15 amFLO - PIT
1 stop3h 14mAmerican Airlines
Deal found 10/11$577
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/266:54 amPIT - FLO
1 stop3h 52mAmerican Airlines
Thu 10/303:19 pmFLO - PIT
1 stop5h 41mAmerican Airlines
Deal found 10/11$765

Cheap flight deals from Ohio to Florence

Keep the following information in mind while searching for Ohio to Florence flight deals. Data was last updated October 13, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$421
(American Airlines)

One-way from

$286
(American Airlines)
Provider with most accurate pricing for Cleveland Hopkins Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Cleveland Hopkins Intl-Florence flights.
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From Ohio to Florence
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One-way flight from Ohio to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Ohio to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 13, 2025.
Use the filters below to find and compare flights from Ohio to Florence that are best for you.

Fly from

Ohio

Fly to

Florence

Route

Depart

Return

Price

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 12/25

11:12 am-6:05 pm

2 stops6h 53m

Florence

Tue 12/30

5:15 am-9:21 am

1 stop4h 06m

$426

CincinnatiFlorence

CVG - FLO

CVGFLO

Cincinnati Cinci./N. Kentucky

Wed 12/10

5:04 pm-10:53 pm

1 stop5h 49m

Florence

Sat 12/13

11:16 am-5:15 pm

1 stop5h 59m

$475

DaytonFlorence

DAY - FLO

DAYFLO

Dayton

Wed 12/10

7:04 pm-10:53 pm

1 stop3h 49m

Florence

Sat 12/13

6:31 pm-10:42 pm

1 stop4h 11m

$475

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 10/31

12:57 pm-6:54 pm

1 stop5h 57m

Florence

Sat 11/8

5:15 am-5:41 pm

2 stops12h 26m

$494

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 10/31

1:12 pm-10:46 am

2 stops21h 34m

Florence

Fri 11/7

6:15 am-4:57 pm

2 stops10h 42m

$497

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 10/30

6:40 pm-11:13 pm

1 stop4h 33m

Florence

Thu 11/6

5:15 am-9:48 am

1 stop4h 33m

$499

AkronFlorence

CAK - FLO

CAKFLO

Akron/Canton

Tue 3/17

5:48 pm-11:38 pm

1 stop5h 50m

Florence

Sat 3/21

2:30 pm-7:39 pm

1 stop5h 09m

$505

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 11/1

6:00 am-10:46 am

1 stop4h 46m

Florence

Sat 11/8

5:15 am-9:48 am

1 stop4h 33m

$511

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 10/31

12:57 pm-6:54 pm

1 stop5h 57m

Florence

Sun 11/9

5:15 am-11:13 am

1 stop5h 58m

$520

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Wed 3/18

10:41 am-2:05 pm

1 stop3h 24m

Florence

Sat 3/21

2:30 pm-7:33 pm

1 stop5h 03m

$521

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/12

Showing 1-10 of 22 results
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Best time to book a flight from Ohio to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Ohio with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Ohio to Florence

What is the cheapest month to book a flight from Ohio to Florence, South Carolina?

Currently, October is the cheapest month in which you can book a flight from Ohio to Florence, South Carolina (average of $41). Flying from Ohio to Florence, South Carolina in December is currently the most expensive (average of $89). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Ohio to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Ohio?

    If you book a flight to Florence from Ohio, you will be flying to Florence, which is the city’s only airport. Florence (FLO) is located 2.3 mi from the center of Florence.

  • How long is the flight from Ohio to Florence, South Carolina?

    Airlines like American Airlines fly from Ohio to Florence, South Carolina in about 6h 53m. The time it takes to get you to your destination can typically vary by up to . The distance between Ohio and Florence, South Carolina is about 589 mi.

  • What are the most popular routes from Ohio to Florence, South Carolina?

    While some choose either Columbus - Florence or Cincinnati Cinci./N. Kentucky - Florence, Detroit Metropolitan Wayne County - Florence is the most popular route from Ohio to Florence, South Carolina.

  • Can I find deals for flights from Ohio to Florence that include hotel bookings?

    Yes. In addition to deals on Ohio to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Ohio to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Ohio to Florence.

  • Can I find deals for business class flights from Ohio to Florence?

    Yes. Cheapflights offers flight deals from Ohio to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Ohio to Florence, South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Ohio to Florence, South Carolina (average of $41). Flying from Ohio to Florence, South Carolina in December is currently the most expensive (average of $89). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Alternative routes for Ohio to Florence

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Top airline flying from Ohio to Florence

Discover the top airline that operate flights from Ohio to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$325Average$479FlexibilityNo cancel feeOn-time71%

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