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$465+ Cheap flights from Cleveland to Florence, SC (CLE - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel.
CLE — FLO
May 20 — May 271
Wed 5/20
Wed 5/27
1 adult, Economy
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Cheap flight deals from Cleveland to Florence

Cheapest flights from Cleveland to Florence
Explore the most affordable flight options available from Cleveland to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 20, 2026.

This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:52 am
CLE
-
FLO
2 stops11h 50m
American Airlines
Sat 5/95:20 am
FLO
-
CLE
2 stops9h 56m
American Airlines
Deal found 4/20$465
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1811:02 am
CLE
-
FLO
2 stops10h 45m
American Airlines
Tue 5/196:15 am
FLO
-
CLE
2 stops12h 14m
American Airlines
Deal found 4/17$535
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/210:05 am
CLE
-
FLO
1 stop5h 45m
American Airlines
Wed 5/64:16 pm
FLO
-
CLE
1 stop5h 49m
American Airlines
Deal found 4/17$541
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:06 pm
CLE
-
FLO
1 stop3h 36m
American Airlines
Tue 4/284:02 pm
FLO
-
CLE
1 stop5h 31m
American Airlines
Deal found 4/18$599
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2110:48 am
CLE
-
FLO
1 stop4h 44m
American Airlines
Sun 4/264:16 pm
FLO
-
CLE
1 stop5h 49m
American Airlines
Deal found 4/18$609
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/212:02 pm
CLE
-
FLO
2 stops8h 40m
American Airlines
Mon 4/275:20 am
FLO
-
CLE
1 stop3h 55m
American Airlines
Deal found 4/18$614
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/710:05 am
CLE
-
FLO
1 stop5h 45m
American Airlines
Sun 5/104:16 pm
FLO
-
CLE
1 stop5h 49m
American Airlines
Deal found 4/16$619

Find flight deals from Cleveland to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Cleveland (CLE) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$465
(American Airlines)
Provider with most accurate pricing for Cleveland Hopkins Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Cleveland Hopkins Intl-Florence flights.
Search Deals
From Cleveland Hopkins Intl to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Cleveland to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 20, 2026.
Use the filters below to find and compare flights from Cleveland to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Mon 5/18

11:02 am-9:47 pm

2 stops10h 45m

Florence

Tue 5/19

6:15 am-6:29 pm

2 stops12h 14m

$535
Quickest round-trip

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Tue 5/5

10:48 am-3:32 pm

1 stop4h 44m

Florence

Sat 5/9

5:20 am-9:15 am

1 stop3h 55m

$541

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Sat 5/2

7:00 am-3:50 pm

2 stops8h 50m

Florence

Wed 5/6

4:16 pm-10:05 pm

1 stop5h 49m

$546

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Sat 5/2

7:00 am-3:50 pm

2 stops8h 50m

Florence

Mon 5/4

4:16 pm-11:59 pm

2 stops7h 43m

$619

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 5/7

10:05 am-3:50 pm

1 stop5h 45m

Florence

Sun 5/10

4:16 pm-10:05 pm

1 stop5h 49m

$619

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/17

Sorted by cheapest first

Compare providers for flights from Cleveland to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Cleveland to Florence in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Cleveland-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Cleveland-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Cleveland-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Cleveland-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Cleveland-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Cleveland to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Cleveland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Cleveland to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Cleveland to Florence, South Carolina?

    For as low as $541, American Airlines can have you in Florence, South Carolina from Cleveland in 4h 44m. Cleveland and Florence, South Carolina are separated by a distance of 512 mi.

  • Can I find deals for flights from Cleveland to Florence that include hotel bookings?

    Yes. In addition to deals on Cleveland to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cleveland to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cleveland to Florence.

  • Can I find deals for business class flights from Cleveland to Florence?

    Yes. Cheapflights offers flight deals from Cleveland to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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