$242+ Cheap flights from Cleveland to Florence, SC (CLE - FLO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
CLE — FLO
Oct 6 — Oct 131
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Cleveland to Florence with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Cleveland to Florence
Cheapest
Best
Last-minute
One-way
Cheapest flights from Cleveland to FlorenceExplore the most affordable flight options available from Cleveland to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
Explore the most affordable flight options available from Cleveland to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 6, 2026.
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/189:39 am -
1 stop3h 39m
Sun 9/205:09 am -
1 stop6h 19m
Deal found 9/5![American Airlines logo]()
$649
Best flights from Cleveland to FlorenceDiscover carefully curated flight deals from Cleveland to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
Discover carefully curated flight deals from Cleveland to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 6, 2026.
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/189:39 am -
1 stop3h 39m
Sun 9/205:09 am -
1 stop6h 19m
Deal found 9/5![American Airlines logo]()
$649
Last-minute flights from Cleveland to FlorenceDiscover last-minute flight deals from Cleveland to Florence. Data last updated September 6, 2026 and is based on user searches.
Discover last-minute flight deals from Cleveland to Florence. Data last updated September 6, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/189:39 am -
1 stop3h 39m
Sun 9/205:09 am -
1 stop6h 19m
Deal found 9/5![American Airlines logo]()
$649
One-way flights from Cleveland to FlorenceSearch for one-way flight options from Cleveland to Florence. Find affordable one-way fares based on user searches. Data last updated September 6, 2026.
Search for one-way flight options from Cleveland to Florence. Find affordable one-way fares based on user searches. Data last updated September 6, 2026.
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/712:51 pm -
2 stops11h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![American Airlines logo]()
$242
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:59 pm -
2 stops18h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![American Airlines logo]()
$317
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/84:59 pm -
2 stops22h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![American Airlines logo]()
$412
Find flight deals from Cleveland to Florence
Discover tips and strategies to find the most affordable flight options for your journey from Cleveland (CLE) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $649 (American Airlines) |
One-way from | $242 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Cleveland to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 6, 2026.
Use the filters below to find and compare flights from Cleveland to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ClevelandFlorence
CLE Cleveland Hopkins Intl - FLO Florence
CLEFLO
Cleveland Hopkins Intl
Wed 10/7
12:51 pm-11:57 pm
2 stops11h 06m
Florence
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$242
ClevelandFlorence
CLE Cleveland Hopkins Intl - FLO Florence
CLEFLO
Cleveland Hopkins Intl
Mon 11/9
8:59 pm-3:16 pm
2 stops18h 17m
Florence
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$317
ClevelandFlorence
CLE Cleveland Hopkins Intl - FLO Florence
CLEFLO
Cleveland Hopkins Intl
Sun 11/8
4:59 pm-3:09 pm
2 stops22h 10m
Florence
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$412
Quickest round-trip
ClevelandFlorence
CLE Cleveland Hopkins Intl - FLO Florence
CLEFLO
Cleveland Hopkins Intl
Fri 9/18
9:39 am-1:18 pm
1 stop3h 39m
Florence
Sun 9/20
5:09 am-11:28 am
1 stop6h 19m
$649
Sorted by cheapest first
Compare providers for flights from Cleveland to Florence
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Cleveland to Florence in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Cleveland-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Cleveland-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Cleveland-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Cleveland-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Cleveland-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Cleveland to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from Cleveland with our price prediction graph.
CLE-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Cleveland to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Florence?
Book flights to Florence if you plan to visit one of these locationsSumter
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Florence flight routes
Other flight options
Other flights from Cleveland
Popular flights