$510+ Cheap flights from Detroit Metropolitan Wayne County Airport to Florence, SC (DTW - FLO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — FLO
Nov 12 — Nov 191
Round-trip
1 adult, Economy
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Find cheap flights from Detroit to Florence with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to Florence
Cheapest
Best
Last-minute
Cheapest flights from Detroit to FlorenceExplore the most affordable flight options available from Detroit to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 13, 2026.
Explore the most affordable flight options available from Detroit to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 13, 2026.
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/281:49 pm -
1 stop5h 45m
Sun 11/12:35 pm -
1 stop4h 25m
Deal found 10/13![American Airlines logo]()
$555
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:49 pm -
1 stop3h 45m
Tue 11/36:24 am -
1 stop4h 06m
Deal found 10/11![American Airlines logo]()
$571
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/87:30 am -
1 stop6h 40m
Sun 11/155:09 am -
1 stop4h 36m
Deal found 10/9![American Airlines logo]()
$585
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:16 am -
1 stop6h 53m
Thu 11/52:35 pm -
1 stop4h 25m
Deal found 10/11![American Airlines logo]()
$620
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:49 pm -
1 stop3h 45m
Wed 11/46:24 am -
2 stops9h 22m
Deal found 10/11![American Airlines logo]()
$648
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:15 am -
1 stop3h 55m
Wed 11/46:24 am -
1 stop4h 06m
Deal found 10/11![American Airlines logo]()
$687
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:15 am -
1 stop3h 55m
Thu 11/52:35 pm -
1 stop4h 25m
Deal found 10/11![American Airlines logo]()
$721
Best flights from Detroit to FlorenceDiscover carefully curated flight deals from Detroit to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 13, 2026.
Discover carefully curated flight deals from Detroit to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 13, 2026.
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2310:18 am -
1 stop3h 52m
Tue 3/92:35 pm -
1 stop4h 39m
Deal found 10/9![American Airlines logo]()
$510
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/281:49 pm -
1 stop5h 45m
Sun 11/12:35 pm -
1 stop4h 25m
Deal found 10/13![American Airlines logo]()
$555
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:49 pm -
1 stop3h 45m
Tue 11/36:24 am -
1 stop4h 06m
Deal found 10/11![American Airlines logo]()
$571
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/87:30 am -
1 stop6h 40m
Sun 11/155:09 am -
1 stop4h 36m
Deal found 10/9![American Airlines logo]()
$585
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:49 pm -
1 stop3h 45m
Wed 11/46:24 am -
2 stops9h 22m
Deal found 10/11![American Airlines logo]()
$648
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:40 pm -
1 stop6h 16m
Tue 11/36:24 am -
1 stop4h 06m
Deal found 10/11![American Airlines logo]()
$687
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:25 pm -
1 stop4h 34m
Wed 11/46:24 am -
1 stop4h 06m
Deal found 10/11![American Airlines logo]()
$687
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:25 pm -
1 stop4h 34m
Thu 11/52:35 pm -
1 stop4h 25m
Deal found 10/11![American Airlines logo]()
$721
Last-minute flights from Detroit to FlorenceDiscover last-minute flight deals from Detroit to Florence. Data last updated October 13, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to Florence. Data last updated October 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/281:49 pm -
1 stop5h 45m
Sun 11/12:35 pm -
1 stop4h 25m
Deal found 10/13![American Airlines logo]()
$555
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:49 pm -
1 stop3h 45m
Tue 11/36:24 am -
1 stop4h 06m
Deal found 10/11![American Airlines logo]()
$571
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:16 am -
1 stop6h 53m
Thu 11/52:35 pm -
1 stop4h 25m
Deal found 10/11![American Airlines logo]()
$620
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:15 am -
1 stop3h 55m
Wed 11/46:24 am -
1 stop4h 06m
Deal found 10/11![American Airlines logo]()
$687
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:15 am -
1 stop3h 55m
Thu 11/52:35 pm -
1 stop4h 25m
Deal found 10/11![American Airlines logo]()
$721
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/87:30 am -
1 stop6h 40m
Sun 11/155:09 am -
1 stop4h 36m
Deal found 10/9![American Airlines logo]()
$585
Find flight deals from Detroit to Florence
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTW) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $510 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 13, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Tue 2/23
10:18 am-2:10 pm
1 stop3h 52m
Florence
Tue 3/9
2:35 pm-7:14 pm
1 stop4h 39m
$510
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Wed 10/28
1:49 pm-7:34 pm
1 stop5h 45m
Florence
Sun 11/1
2:35 pm-7:00 pm
1 stop4h 25m
$555
Quickest round-trip
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Sat 10/31
1:49 pm-5:34 pm
1 stop3h 45m
Florence
Tue 11/3
6:24 am-10:30 am
1 stop4h 06m
$571
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Sun 11/8
7:30 am-2:10 pm
1 stop6h 40m
Florence
Sun 11/15
5:09 am-9:45 am
1 stop4h 36m
$585
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Sat 10/31
1:49 pm-5:34 pm
1 stop3h 45m
Florence
Wed 11/4
6:24 am-3:46 pm
2 stops9h 22m
$648
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Sun 11/1
5:40 pm-11:56 pm
1 stop6h 16m
Florence
Tue 11/3
6:24 am-10:30 am
1 stop4h 06m
$687
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Mon 11/2
6:25 pm-10:59 pm
1 stop4h 34m
Florence
Wed 11/4
6:24 am-10:30 am
1 stop4h 06m
$687
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Mon 11/2
6:25 pm-10:59 pm
1 stop4h 34m
Florence
Thu 11/5
2:35 pm-7:00 pm
1 stop4h 25m
$721
Sorted by cheapest first
Compare providers for flights from Detroit to Florence
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Florence in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit Metropolitan Wayne County Airport-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from Detroit with our price prediction graph.
DTW-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Detroit to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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