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$316+ Cheap flights from Florence, SC (FLO) to Ohio

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/1. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — CLE
Jun 6 — Jun 131
Sat 6/6
Sat 6/13
1 adult, Economy
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Cheap flight deals from Florence to Ohio

Cheapest flights from Florence to Ohio
Explore the most affordable flight options available from Florence to Ohio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2026.

This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:05 am
FLO
-
DTW
2 stops11h 36m
American Airlines
Sun 5/319:18 am
DTW
-
FLO
2 stops12h 42m
American Airlines
Deal found 5/6$478
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:20 am
FLO
-
DTW
1 stop4h 07m
American Airlines
Mon 5/1110:11 am
DTW
-
FLO
1 stop5h 39m
American Airlines
Deal found 5/2$489
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2112:51 pm
FLO
-
PIT
2 stops10h 18m
American Airlines
Mon 12/288:04 am
PIT
-
FLO
2 stops10h 01m
American Airlines
Deal found 5/4$547
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:35 pm
FLO
-
CAK
1 stop5h 41m
American Airlines
Sun 5/314:00 pm
CAK
-
FLO
1 stop6h 00m
American Airlines
Deal found 5/6$605
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:20 am
FLO
-
CVG
1 stop4h 22m
American Airlines
Sun 5/2410:06 am
CVG
-
FLO
2 stops11h 54m
American Airlines
Deal found 5/5$615
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:20 am
FLO
-
DTW
1 stop4h 07m
American Airlines
Mon 5/1111:57 am
DTW
-
FLO
1 stop3h 53m
American Airlines
Deal found 5/7$639
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/312:35 pm
FLO
-
PIT
1 stop4h 54m
American Airlines
Sun 6/79:44 am
PIT
-
FLO
1 stop4h 26m
American Airlines
Deal found 5/3$640
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:05 am
FLO
-
HTS
1 stop41h 04m
American Airlines
Mon 6/112:21 pm
HTS
-
FLO
1 stop25h 49m
American Airlines
Deal found 5/5$881
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:20 am
FLO
-
DTW
1 stop5h 57m
American Airlines
Fri 5/224:17 pm
DTW
-
FLO
1 stop5h 43m
American Airlines
Deal found 5/2$955

Find flight deals from Florence to Ohio

Keep the following information in mind while searching for Florence to Ohio flight deals. Data was last updated May 7, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$478
(American Airlines)

One-way from

$316
(American Airlines)
Provider with most accurate pricing for Florence-Cleveland Hopkins Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-Cleveland Hopkins Intl flights.
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From Florence to Ohio
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One-way flight from Florence to Ohio
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Ohio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 7, 2026.
Use the filters below to find and compare flights from Florence to Ohio that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceDetroit

FLO - DTW

FLODTW

Florence

Wed 5/27

5:05 am-4:41 pm

2 stops11h 36m

Detroit Metropolitan Wayne County

Sun 5/31

9:18 am-10:00 pm

2 stops12h 42m

$478

FlorenceAkron

FLO - CAK

FLOCAK

Florence

Fri 5/29

2:35 pm-8:16 pm

1 stop5h 41m

Akron/Canton

Sun 5/31

4:00 pm-10:00 pm

1 stop6h 00m

$605

FlorenceCincinnati

FLO - CVG

FLOCVG

Florence

Wed 5/20

5:20 am-9:42 am

1 stop4h 22m

Cincinnati Cinci./N. Kentucky

Sun 5/24

10:06 am-10:00 pm

2 stops11h 54m

$615

FlorencePittsburgh

FLO - PIT

FLOPIT

Florence

Sun 5/31

5:05 am-8:54 am

1 stop3h 49m

Pittsburgh

Sun 6/7

6:12 am-2:10 pm

2 stops7h 58m

$645

FlorenceHuntington

FLO - HTS

FLOHTS

Florence

Tue 5/26

5:05 am-10:09 pm

1 stop41h 04m

Huntington Tri State

Mon 6/1

12:21 pm-2:10 pm

1 stop25h 49m

$881
Quickest round-trip

FlorenceDetroit

FLO - DTW

FLODTW

Florence

Mon 5/18

5:20 am-11:17 am

1 stop5h 57m

Detroit Metropolitan Wayne County

Fri 5/22

4:17 pm-10:00 pm

1 stop5h 43m

$955
Cheapest one-way
Quickest one-way

FlorenceDetroit

FLO - DTW

FLODTW

Florence

Sat 8/1

2:35 pm-7:18 pm

1 stop4h 43m

$444

FlorenceDayton

FLO - DAY

FLODAY

Florence

Sun 5/17

4:16 pm-10:03 pm

1 stop5h 47m

$478

FlorenceDetroit

FLO - DTW

FLODTW

Florence

Thu 6/11

2:35 pm-7:18 pm

1 stop4h 43m

$478

FlorenceDetroit

FLO - DTW

FLODTW

Florence

Sun 5/17

5:20 am-5:02 pm

2 stops11h 42m

$483

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/3

Sorted by cheapest first

Best time to book a flight from Florence to Ohio

Have a flexible travel schedule? Discover the best time to fly to Ohio from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Ohio
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Florence to Ohio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Ohio?

    Most people fly from Florence (FLO) if they book a flight from Florence to Ohio. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Florence, South Carolina to Ohio?

    There are many flights that can get you from Florence, South Carolina to Ohio in 11h 36m. Fly via American Airlines to get the fastest option. The distance between Florence, South Carolina and Ohio is about 589 mi.

  • What are the most popular routes from Florence, South Carolina to Ohio?

    The most popular flight routes from Florence, South Carolina to Ohio are Florence - Akron/Canton, Florence - Dayton and Florence - Cincinnati Cinci./N. Kentucky.

  • Can I find deals for flights from Florence to Ohio that include hotel bookings?

    Yes. In addition to deals on Florence to Ohio flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Ohio?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Ohio.

  • Can I find deals for business class flights from Florence to Ohio?

    Yes. Cheapflights offers flight deals from Florence to Ohio by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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