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Florence

$323+ Cheap flights from Ohio to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/1. Fares are subject to change and may not be available on all flights or dates of travel.
CLE — FLO
Jun 4 — Jun 111
Thu 6/4
Thu 6/11
1 adult, Economy
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Cheap flight deals from Ohio to Florence

Cheapest flights from Ohio to Florence
Explore the most affordable flight options available from Ohio to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.

This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/14:17 pm
DTW
-
FLO
1 stop5h 43m
American Airlines
Tue 7/72:35 pm
FLO
-
DTW
1 stop4h 38m
American Airlines
Deal found 5/1$323
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/34:17 pm
DTW
-
FLO
1 stop5h 43m
American Airlines
Wed 6/102:35 pm
FLO
-
DTW
1 stop4h 43m
American Airlines
Deal found 5/4$343
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:00 am
DTW
-
FLO
2 stops8h 10m
American Airlines
Sun 7/52:35 pm
FLO
-
DTW
1 stop4h 43m
American Airlines
Deal found 5/1$358
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/210:01 am
DTW
-
FLO
1 stop4h 09m
American Airlines
Sun 6/72:35 pm
FLO
-
DTW
1 stop4h 43m
American Airlines
Deal found 5/3$373
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:12 am
DTW
-
FLO
1 stop4h 20m
American Airlines
Sat 5/235:05 am
FLO
-
DTW
1 stop4h 12m
American Airlines
Deal found 5/4$415
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/110:49 am
PIT
-
FLO
2 stops11h 11m
American Airlines
Sun 6/75:05 am
FLO
-
PIT
2 stops9h 53m
American Airlines
Deal found 5/2$425
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:49 am
CVG
-
FLO
1 stop3h 32m
American Airlines
Sat 9/196:31 pm
FLO
-
CVG
1 stop5h 30m
American Airlines
Deal found 5/1$481
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/59:09 am
PIT
-
FLO
2 stops12h 51m
American Airlines
Sat 6/65:05 am
FLO
-
PIT
2 stops11h 05m
American Airlines
Deal found 4/30$493
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1910:52 am
CLE
-
FLO
2 stops11h 50m
American Airlines
Sat 5/235:05 am
FLO
-
CLE
1 stop5h 46m
American Airlines
Deal found 5/4$503
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/278:02 am
CAK
-
FLO
1 stop6h 08m
American Airlines
Mon 6/292:35 pm
FLO
-
CAK
1 stop5h 41m
American Airlines
Deal found 5/2$518
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:08 am
PIT
-
FLO
1 stop4h 24m
American Airlines
Sat 5/235:05 am
FLO
-
PIT
1 stop3h 49m
American Airlines
Deal found 5/4$529
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:21 am
CMH
-
FLO
1 stop4h 11m
American Airlines
Sat 5/235:05 am
FLO
-
CMH
1 stop6h 14m
American Airlines
Deal found 5/4$541

Find flight deals from Ohio to Florence

Keep the following information in mind while searching for Ohio to Florence flight deals. Data was last updated May 5, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$323
(American Airlines)
Provider with most accurate pricing for Cleveland Hopkins Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Cleveland Hopkins Intl-Florence flights.
Search Deals
From Ohio to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Ohio to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from Ohio to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 7/1

4:17 pm-10:00 pm

1 stop5h 43m

Florence

Tue 7/7

2:35 pm-7:13 pm

1 stop4h 38m

$323

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 6/3

4:17 pm-10:00 pm

1 stop5h 43m

Florence

Wed 6/10

2:35 pm-7:18 pm

1 stop4h 43m

$343

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 7/1

6:00 am-2:10 pm

2 stops8h 10m

Florence

Sun 7/5

2:35 pm-7:18 pm

1 stop4h 43m

$358

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Tue 6/2

6:40 am-2:10 pm

2 stops7h 30m

Florence

Sun 6/7

5:05 am-9:17 am

1 stop4h 12m

$378

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sun 5/31

4:17 pm-10:00 pm

1 stop5h 43m

Florence

Sun 6/7

5:05 am-9:17 am

1 stop4h 12m

$446
Quickest round-trip

CincinnatiFlorence

CVG - FLO

CVGFLO

Cincinnati Cinci./N. Kentucky

Sat 9/19

6:49 am-10:21 am

1 stop3h 32m

Florence

Sat 9/26

6:31 pm-9:54 pm

1 stop3h 23m

$481

CincinnatiFlorence

CVG - FLO

CVGFLO

Cincinnati Cinci./N. Kentucky

Sat 9/12

3:38 pm-12:13 am

2 stops8h 35m

Florence

Sat 9/19

6:31 pm-12:01 am

1 stop5h 30m

$486

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Mon 6/1

10:49 am-10:00 pm

2 stops11h 11m

Florence

Sun 6/7

5:05 am-8:54 am

1 stop3h 49m

$493

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Tue 5/19

10:52 am-10:42 pm

2 stops11h 50m

Florence

Sat 5/23

5:05 am-10:51 am

1 stop5h 46m

$503

AkronFlorence

CAK - FLO

CAKFLO

Akron/Canton

Sat 6/27

8:02 am-2:10 pm

1 stop6h 08m

Florence

Mon 6/29

2:35 pm-8:16 pm

1 stop5h 41m

$518

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/1

Showing 1-10 of 33 resultsSorted by cheapest first
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Best time to book a flight from Ohio to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Ohio with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Ohio to Florence
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Ohio to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Ohio?

    If you book a flight to Florence from Ohio, you will be flying to Florence, which is the city’s only airport. Florence (FLO) is located 2.3 mi from the center of Florence.

  • How long is the flight from Ohio to Florence, South Carolina?

    Airlines like American Airlines fly from Ohio to Florence, South Carolina in about 5h 43m. The time it takes to get you to your destination can typically vary by up to . The distance between Ohio and Florence, South Carolina is about 589 mi.

  • What are the most popular routes from Ohio to Florence, South Carolina?

    While some choose either Detroit Metropolitan Wayne County - Florence or Cincinnati Cinci./N. Kentucky - Florence, Cleveland Hopkins Intl - Florence is the most popular route from Ohio to Florence, South Carolina.

  • Can I find deals for flights from Ohio to Florence that include hotel bookings?

    Yes. In addition to deals on Ohio to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Ohio to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Ohio to Florence.

  • Can I find deals for business class flights from Ohio to Florence?

    Yes. Cheapflights offers flight deals from Ohio to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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