HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$443+ Cheap flights from Pittsburgh to Florence, SC (PIT - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/1. Fares are subject to change and may not be available on all flights or dates of travel.
PIT — FLO
May 23 — May 301
Sat 5/23
Sat 5/30
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Pittsburgh to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Pittsburgh to Florence

Cheapest flights from Pittsburgh to Florence
Explore the most affordable flight options available from Pittsburgh to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.

This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:58 pm
PIT
-
FLO
1 stop3h 49m
American Airlines
Wed 5/275:05 am
FLO
-
PIT
2 stops10h 01m
American Airlines
Deal found 4/22$477
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2811:08 am
PIT
-
FLO
1 stop4h 24m
American Airlines
Tue 5/126:15 am
FLO
-
PIT
1 stop3h 59m
American Airlines
Deal found 4/19$529
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2910:33 am
PIT
-
FLO
1 stop5h 17m
American Airlines
Sat 5/25:20 am
FLO
-
PIT
1 stop4h 23m
American Airlines
Deal found 4/19$609
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:54 am
PIT
-
FLO
2 stops8h 56m
American Airlines
Sun 5/34:16 pm
FLO
-
PIT
1 stop4h 42m
American Airlines
Deal found 4/19$624
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:58 pm
PIT
-
FLO
1 stop3h 49m
American Airlines
Sun 5/35:20 am
FLO
-
PIT
1 stop4h 23m
American Airlines
Deal found 4/21$629

Find flight deals from Pittsburgh to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Pittsburgh (PIT) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$477
(American Airlines)

One-way from

$443
(American Airlines)
Provider with most accurate pricing for Pittsburgh-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Pittsburgh-Florence flights.
Search Deals
From Pittsburgh to Florence
Search Deals
One-way flight from Pittsburgh to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Pittsburgh to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from Pittsburgh to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Wed 5/20

5:58 pm-9:47 pm

1 stop3h 49m

Florence

Wed 5/27

5:05 am-3:06 pm

2 stops10h 01m

$477

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Tue 5/5

4:04 pm-10:42 pm

1 stop6h 38m

Florence

Sat 5/9

4:16 pm-8:58 pm

1 stop4h 42m

$529
Quickest round-trip

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Sun 5/3

10:33 am-3:50 pm

1 stop5h 17m

Florence

Mon 5/4

5:20 am-9:43 am

1 stop4h 23m

$645

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Mon 5/4

10:33 am-3:50 pm

1 stop5h 17m

Florence

Fri 5/8

4:16 pm-8:58 pm

1 stop4h 42m

$885
Cheapest one-way
Quickest one-way

PittsburghFlorence

PIT - FLO

PITFLO

Pittsburgh

Fri 5/1

10:33 am-3:50 pm

1 stop5h 17m

$443

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/21

Sorted by cheapest first

Compare providers for flights from Pittsburgh to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Pittsburgh to Florence in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Pittsburgh-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Pittsburgh-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Pittsburgh-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Pittsburgh-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Pittsburgh-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Pittsburgh to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Pittsburgh with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Pittsburgh to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Pittsburgh to Florence, South Carolina?

    American Airlines can get you from Pittsburgh to Florence, South Carolina in just under 3h 49m. Your travel time can differ by up to . The distance from Pittsburgh to Florence, South Carolina is about 437 mi.

  • Can I find deals for flights from Pittsburgh to Florence that include hotel bookings?

    Yes. In addition to deals on Pittsburgh to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Pittsburgh to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Pittsburgh to Florence.

  • Can I find deals for business class flights from Pittsburgh to Florence?

    Yes. Cheapflights offers flight deals from Pittsburgh to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Pittsburgh to Florence

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Charleston flights
Newark to Charleston flights
LaGuardia to Charleston flights
Newark to Charlotte flights
LaGuardia to Charlotte flights
John F Kennedy Intl to Charlotte flights
John F Kennedy Intl to Savannah flights
Newark to Savannah flights
LaGuardia to Savannah flights
Newark to Myrtle Beach flights
John F Kennedy Intl to Myrtle Beach flights
Dulles Intl to Charlotte flights
LaGuardia to Myrtle Beach flights
Dulles Intl to Charleston flights
Philadelphia to Charleston flights
Reagan-National to Charlotte flights
Newark to Greenville flights
Philadelphia to Myrtle Beach flights
Philadelphia to Charlotte flights
LaGuardia to Greenville flights
Reagan-National to Savannah flights
Reagan-National to Charleston flights
Dulles Intl to Savannah flights
John F Kennedy Intl to Greenville flights
Pittsburgh to Myrtle Beach flights
Dulles Intl to Myrtle Beach flights
Philadelphia to Savannah flights
LaGuardia to Hilton Head Island flights
Newark to Columbia flights
Pittsburgh to Charleston flights
Newark to Hilton Head Island flights
Reagan-National to Myrtle Beach flights
John F Kennedy Intl to Columbia flights
Reagan-National to Columbia flights
LaGuardia to Columbia flights
Dulles Intl to Greenville flights
Dulles Intl to Columbia flights
Allentown to Myrtle Beach flights
Pittsburgh to Charlotte flights
Allentown to Charlotte flights
Philadelphia to Greenville flights
Pittsburgh to Hilton Head Island flights
Latrobe to Myrtle Beach flights
Philadelphia to Columbia flights
Newark to Augusta flights
Harrisburg to Charlotte flights
Reagan-National to Greenville flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.