HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$97+ Cheap flights from South Carolina to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from South Carolina to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from South Carolina to Des Moines

Keep the following information in mind while searching for South Carolina to Des Moines flight deals. Data was last updated July 31, 2025.

Round-trip from

$219
(Mytrip)

One-way from

$97
(Mytrip)
From South Carolina to Des Moines
Search Deals
One-way flight from South Carolina to Des Moines
Search Deals

Find flight deals from South Carolina to Des Moines

Cheapest flights from South Carolina to Des Moines
Explore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This Mytrip deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/49:52 pmCLT - DSM
2 stops16h 40mMultiple Airlines
Sun 9/75:49 pmDSM - CLT
2 stops21h 42mMultiple Airlines
Deal found 7/31$219
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/188:37 pmSAV - DSM
1 stop4h 38mAmerican Airlines
Sun 9/215:00 amDSM - SAV
1 stop5h 35mAmerican Airlines
Deal found 7/31$236
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:25 amGSP - DSM
1 stop6h 39mDelta
Sun 11/26:39 pmDSM - GSP
1 stop4h 15mDelta
Deal found 7/31$237
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/311:31 amMYR - DSM
1 stop6h 14mDelta
Tue 9/96:30 pmDSM - MYR
1 stop4h 19mDelta
Deal found 7/30$237
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/410:13 amMYR - DSM
1 stop7h 36mAmerican Airlines
Sun 9/76:11 pmDSM - MYR
1 stop4h 43mAmerican Airlines
Deal found 7/31$243
This Mytrip deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/45:20 pmCLT - DSM
1 stop21h 20mFrontier
Sun 9/72:25 pmDSM - CLT
1 stop25h 00mFrontier
Deal found 7/31$247
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/215:40 amCAE - DSM
1 stop5h 58mDelta
Sat 8/235:44 amDSM - CAE
1 stop5h 35mDelta
Deal found 7/30$249
This Mytrip deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/46:00 amMYR - DSM
2 stops11h 59mMultiple Airlines
Sun 9/75:49 pmDSM - MYR
2 stops17h 08mMultiple Airlines
Deal found 7/31$257
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/217:34 pmCAE - DSM
1 stop5h 16mAmerican Airlines
Sun 8/246:12 pmDSM - CAE
1 stop4h 47mAmerican Airlines
Deal found 7/31$273
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/257:50 pmCLT - DSM
1 stop4h 00mSouthwest
Mon 9/296:00 amDSM - CLT
1 stop10h 35mSouthwest
Deal found 7/30$286
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/202:55 pmMYR - DSM
2 stops7h 40mSouthwest
Fri 11/285:45 amDSM - MYR
2 stops10h 30mSouthwest
Deal found 7/30$338
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/218:40 pmAGS - DSM
1 stop4h 05mAmerican Airlines
Sat 8/3010:49 amDSM - AGS
1 stop7h 36mAmerican Airlines
Deal found 7/30$363

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.

Fly from

South Carolina

Fly to

Des Moines

Route

Depart

Return

Price

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 9/4

9:52 pm-1:32 pm

2 stops16h 40m

Des Moines

Sun 9/7

5:49 pm-4:31 pm

2 stops21h 42m

$219

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

Thu 9/18

8:37 pm-12:15 am

1 stop4h 38m

Des Moines

Sun 9/21

5:00 am-11:35 am

1 stop5h 35m

$236

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 10/30

6:25 am-12:04 pm

1 stop6h 39m

Des Moines

Sun 11/2

6:39 pm-11:54 pm

1 stop4h 15m

$237

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 9/3

11:31 am-4:45 pm

1 stop6h 14m

Des Moines

Tue 9/9

6:30 pm-11:49 pm

1 stop4h 19m

$237

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 9/4

10:13 am-4:49 pm

1 stop7h 36m

Des Moines

Sun 9/7

6:11 pm-11:54 pm

1 stop4h 43m

$243

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 9/4

5:20 pm-1:40 pm

1 stop21h 20m

Des Moines

Sun 9/7

2:25 pm-4:25 pm

1 stop25h 00m

$247

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Thu 8/21

5:40 am-10:38 am

1 stop5h 58m

Des Moines

Sat 8/23

5:44 am-12:19 pm

1 stop5h 35m

$249

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Thu 9/4

6:00 am-4:59 pm

2 stops11h 59m

Des Moines

Sun 9/7

5:49 pm-11:57 am

2 stops17h 08m

$257

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Thu 8/21

7:34 pm-11:50 pm

1 stop5h 16m

Des Moines

Sun 8/24

6:12 pm-11:59 pm

1 stop4h 47m

$273

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 9/25

7:50 pm-10:50 pm

1 stop4h 00m

Des Moines

Mon 9/29

6:00 am-5:35 pm

1 stop10h 35m

$286

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Showing 1-10 of 46 results
1
2
3
...
5

Best time to book a flight from South Carolina to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Des Moines

What is the cheapest month to book a flight from South Carolina to Des Moines?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $336). Flying from South Carolina to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to DSM?

Find hourly flight availability from South Carolina to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Des Moines as you normally would.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated July 31, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from South Carolina to Des Moines have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,246 reviews
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,981 reviews
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,900 reviews
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Allegiant Air
7.2
Good
702 reviews
Southwest
8.0
Very good
4,246 reviews

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from South Carolina?

    Des Moines (DSM) is the airport you will fly into if you book a flight from South Carolina to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • What are the cheapest airlines to fly from South Carolina to Des Moines one-way?

    One-way options have recently been found by users for as low as $119 on American Airlines. Other airlines that offer cheap prices include Southwest from $124 and Frontier from $127 one-way.

  • What are the most popular routes from South Carolina to Des Moines?

    When deciding which route to take from South Carolina to Des Moines consider Charlotte Douglas - Des Moines, Greenville - Des Moines or Columbia Metropolitan - Des Moines as they are the most popular.

  • Can I find deals for flights from South Carolina to Des Moines that include hotel bookings?

    Yes. In addition to deals on South Carolina to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Des Moines.

  • Can I find deals for business class flights from South Carolina to Des Moines?

    Yes. Cheapflights offers flight deals from South Carolina to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $336). Flying from South Carolina to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
Seattle to Omaha flights
Denver to Omaha flights
LaGuardia to Omaha flights
Denver to Cedar Rapids flights
Denver to Des Moines flights
Sky Harbor Intl to Des Moines flights
John F Kennedy Intl to Omaha flights
LaGuardia to Des Moines flights
Philadelphia to Omaha flights
Dallas/Fort Worth to Omaha flights
Seattle to Des Moines flights
Newark to Omaha flights
O'Hare Intl to Omaha flights
O'Hare Intl to Des Moines flights
Dallas/Fort Worth to Des Moines flights
Charlotte to Des Moines flights
George Bush Intcntl to Des Moines flights
John F Kennedy Intl to Des Moines flights
Atlanta to Omaha flights
Hobby to Des Moines flights
San Diego to Moline flights
Asheville to Omaha flights
Reagan-National to Omaha flights
Los Angeles to Omaha flights
Sky Harbor Intl to Cedar Rapids flights
Reagan-National to Des Moines flights
Detroit to Des Moines flights
Dallas/Fort Worth to Cedar Rapids flights
Ontario to Cedar Rapids flights
San Francisco to Omaha flights
San Diego to Cedar Rapids flights
Nashville to Omaha flights
Dulles Intl to Omaha flights
Los Angeles to Des Moines flights
Greenville to Des Moines flights
Newark to Cedar Rapids flights
Los Angeles to Cedar Rapids flights
Atlanta to Des Moines flights
Sky Harbor Intl to Omaha flights
John F Kennedy Intl to Cedar Rapids flights
Austin to Omaha flights
Dulles Intl to Des Moines flights
Reagan-National to Cedar Rapids flights
Baltimore to Omaha flights
LaGuardia to Cedar Rapids flights
Santa Ana to Omaha flights
Salt Lake City to Omaha flights
Ontario to Omaha flights
Detroit to Omaha flights
George Bush Intcntl to Omaha flights

Top 2 airlines flying from South Carolina to Des Moines

Discover the top 2 airlines that operate flights from South Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$354FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$400FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.