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Des Moines

$84+ Cheap flights from South Carolina to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/4. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Dec 5 — Dec 121
Fri 12/5
Fri 12/12
1 adult, Economy
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Find flight deals from South Carolina to Des Moines

Cheapest flights from South Carolina to Des Moines
Explore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:44 pmCLT - DSM
1 stop26h 19mFrontier
Mon 12/157:58 pmDSM - CLT
2 stops12h 52mFrontier
Deal found 11/4$238
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:58 pmCLT - DSM
1 stop8h 23mMultiple Airlines
Mon 12/156:35 amDSM - CLT
1 stop28h 29mMultiple Airlines
Deal found 11/4$243
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/85:34 amCAE - DSM
1 stop6h 04mDelta
Mon 12/157:43 amDSM - CAE
1 stop6h 25mDelta
Deal found 11/4$249
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:58 pmCLT - DSM
1 stop8h 23mMultiple Airlines
Sun 12/142:56 pmDSM - CLT
1 stop17h 43mMultiple Airlines
Deal found 11/4$253
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/96:38 amCAE - DSM
1 stop5h 00mDelta
Sat 12/136:50 amDSM - CAE
2 stops9h 10mDelta
Deal found 11/4$254
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/912:53 pmCAE - DSM
2 stops8h 53mDelta
Mon 12/152:59 pmDSM - CAE
2 stops7h 32mDelta
Deal found 11/4$259
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:09 pmCLT - DSM
2 stops29h 36mMultiple Airlines
Mon 12/16:53 pmDSM - CLT
1 stop18h 13mMultiple Airlines
Deal found 11/3$261
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/239:24 pmCLT - DSM
1 stop24h 03mMultiple Airlines
Tue 12/303:45 pmDSM - CLT
1 stop16h 54mMultiple Airlines
Deal found 11/4$262
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:34 pmCLT - DSM
1 stop22h 23mMultiple Airlines
Tue 12/303:45 pmDSM - CLT
1 stop27h 48mMultiple Airlines
Deal found 11/5$268
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/252:46 pmMYR - DSM
1 stop9h 38mMultiple Airlines
Mon 12/16:53 pmDSM - MYR
1 stop28h 01mMultiple Airlines
Deal found 11/5$269
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2410:40 amMYR - DSM
2 stops27h 51mMultiple Airlines
Mon 12/16:53 pmDSM - MYR
1 stop28h 01mMultiple Airlines
Deal found 11/5$276
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/239:24 pmCLT - DSM
1 stop24h 03mMultiple Airlines
Wed 12/311:45 pmDSM - CLT
1 stop27h 39mMultiple Airlines
Deal found 11/4$278

Cheap flight deals from South Carolina to Des Moines

Keep the following information in mind while searching for South Carolina to Des Moines flight deals. Data was last updated November 5, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$238
(Kiwi.com)

One-way from

$84
(Trip.com)

Popular in

December

Cheapest in

July

Average price

$298
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
Search Deals
From South Carolina to Des Moines
Search Deals
One-way flight from South Carolina to Des Moines
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($78 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.

Fly from

South Carolina

Fly to

Des Moines

Route

Depart

Return

Price

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Wed 12/10

5:34 am-10:38 am

1 stop6h 04m

Des Moines

Tue 12/16

6:33 pm-11:31 pm

1 stop3h 58m

$249

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Thu 12/11

5:34 am-10:38 am

1 stop6h 04m

Des Moines

Sun 12/14

6:33 pm-11:31 pm

1 stop3h 58m

$249

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Thu 12/11

5:34 am-10:38 am

1 stop6h 04m

Des Moines

Mon 12/15

7:43 am-3:08 pm

1 stop6h 25m

$249

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Sat 12/13

5:45 pm-10:34 pm

1 stop5h 49m

Des Moines

Tue 12/16

5:34 am-12:08 pm

1 stop5h 34m

$249

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Tue 12/9

12:53 pm-5:47 pm

1 stop5h 54m

Des Moines

Sat 12/13

11:23 am-5:00 pm

1 stop4h 37m

$249

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Mon 12/8

5:34 am-10:38 am

1 stop6h 04m

Des Moines

Sun 12/14

6:33 pm-11:31 pm

1 stop3h 58m

$249

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Wed 12/10

5:34 am-10:38 am

1 stop6h 04m

Des Moines

Sat 12/13

11:23 am-6:57 pm

1 stop6h 34m

$249

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Thu 12/11

5:34 am-10:38 am

1 stop6h 04m

Des Moines

Sat 12/13

11:23 am-6:57 pm

1 stop6h 34m

$249

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Mon 12/8

6:38 am-10:38 am

1 stop5h 00m

Des Moines

Sat 12/13

6:50 am-5:00 pm

2 stops9h 10m

$254

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Thu 12/11

5:34 am-2:19 pm

2 stops9h 45m

Des Moines

Tue 12/16

5:34 am-12:08 pm

1 stop5h 34m

$254

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Showing 1-10 of 52 results
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Best time to book a flight from South Carolina to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Des Moines

What is the cheapest month to book a flight from South Carolina to Des Moines?

Currently, September is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $162). Flying from South Carolina to Des Moines in December is currently the most expensive (average of $424). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to DSM?

Find hourly flight availability from South Carolina to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 5, 2025.

It’s typically best to fly out from South Carolina to Des Moines in the afternoon. Doing so could potentially save you 16% on the flight price compared to flying in the morning, which is usually more expensive.

What is the cheapest day to fly from South Carolina to Des Moines?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Des Moines. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to Des Moines flight should consider departing on Saturday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from South Carolina?

    Des Moines (DSM) is the airport you will fly into if you book a flight from South Carolina to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • How long is the flight from South Carolina to Des Moines?

    Delta and American Airlines can get you from South Carolina to Des Moines in just under 5h 18m. Your travel time can differ by up to 46m. South Carolina and Des Moines are separated by a distance of 956 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Des Moines one-way?

    One-way options have recently been found by users for as low as $85 on Frontier. Other airlines that offer cheap prices include American Airlines from $170 and Delta from $194 one-way.

  • What are the most popular routes from South Carolina to Des Moines?

    When deciding which route to take from South Carolina to Des Moines consider Charlotte Douglas - Des Moines, Greenville - Des Moines or Columbia Metropolitan - Des Moines as they are the most popular.

  • Can I find deals for flights from South Carolina to Des Moines that include hotel bookings?

    Yes. In addition to deals on South Carolina to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Des Moines.

  • Can I find deals for business class flights from South Carolina to Des Moines?

    Yes. Cheapflights offers flight deals from South Carolina to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $162). Flying from South Carolina to Des Moines in December is currently the most expensive (average of $424). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for South Carolina to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Des Moines

Discover the top 3 airlines that operate flights from South Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$395FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$393FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$326Average$571FlexibilityNo cancel feeOn-time69%

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