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Des Moines

$114+ Cheap flights from South Carolina to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
oct. 19 — oct. 261
dom. 10/19
dom. 10/26
1 adult, Economy
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Cheap flight deals from South Carolina to Des Moines

Keep the following information in mind while searching for South Carolina to Des Moines flight deals. Data was last updated septiembre 19, 2025.

Round-trip from

$222
(Kiwi.com)

One-way from

$114
(Kiwi.com)
From South Carolina to Des Moines
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One-way flight from South Carolina to Des Moines
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Find flight deals from South Carolina to Des Moines

Cheapest flights from South Carolina to Des Moines
Explore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 19, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/72:59 pmCHS - DSM
2 stops23h 53mMultiple Airlines
lun. 10/138:30 amDSM - CHS
1 stop10h 45mMultiple Airlines
Deal found 9/18$222
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/85:37 pmSAV - DSM
1 stop5h 53mDelta
lun. 10/206:39 pmDSM - SAV
1 stop4h 19mDelta
Deal found 9/17$248
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/104:40 pmCLT - DSM
1 stop5h 23mDelta
mié. 10/155:47 amDSM - CLT
1 stop6h 55mDelta
Deal found 9/18$257
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/39:10 amCLT - DSM
1 stop6h 40mMultiple Airlines
dom. 10/510:41 amDSM - CLT
1 stop22h 35mMultiple Airlines
Deal found 9/15$270
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/104:40 pmCLT - DSM
1 stop5h 23mDelta
mar. 10/1410:00 amDSM - CLT
1 stop4h 55mDelta
Deal found 9/18$277
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/305:30 amGSP - DSM
1 stop5h 35mDelta
mar. 11/47:20 amDSM - GSP
1 stop6h 10mDelta
Deal found 9/17$285
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/148:04 pmGSP - DSM
1 stop4h 58mAmerican Airlines
vie. 10/176:22 pmDSM - GSP
1 stop4h 29mAmerican Airlines
Deal found 9/17$287
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/152:40 pmCLT - DSM
2 stops20h 11mMultiple Airlines
dom. 10/1910:41 amDSM - CLT
1 stop22h 35mMultiple Airlines
Deal found 9/18$288
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/3012:05 pmGSP - DSM
1 stop5h 57mAmerican Airlines
mar. 11/42:19 pmDSM - GSP
2 stops7h 41mAmerican Airlines
Deal found 9/17$290
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/107:20 amCLT - DSM
1 stop26h 09mMultiple Airlines
dom. 10/1210:41 amDSM - CLT
1 stop11h 47mMultiple Airlines
Deal found 9/15$291
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/306:00 amGSP - DSM
2 stops9h 19mUnited Airlines
mar. 11/411:26 amDSM - GSP
2 stops11h 30mUnited Airlines
Deal found 9/17$295
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/93:09 pmCLT - DSM
2 stops17h 56mMultiple Airlines
dom. 10/1210:41 amDSM - CLT
1 stop22h 35mMultiple Airlines
Deal found 9/16$298

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 19, 2025.
Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.

Fly from

South Carolina

Fly to

Des Moines

Route

Depart

Return

Price

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

mar. 10/7

2:59 pm-1:52 pm

2 stops23h 53m

Des Moines

lun. 10/13

8:30 am-8:15 pm

1 stop10h 45m

$222

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

mié. 10/8

5:37 pm-10:30 pm

1 stop5h 53m

Des Moines

lun. 10/20

6:39 pm-11:58 pm

1 stop4h 19m

$248

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

jue. 11/13

5:30 am-10:42 am

1 stop6h 12m

Des Moines

mar. 11/18

4:59 pm-11:15 pm

1 stop5h 16m

$257

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

vie. 10/10

4:40 pm-9:03 pm

1 stop5h 23m

Des Moines

mié. 10/15

5:47 am-1:42 pm

1 stop6h 55m

$257

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

sáb. 12/6

5:00 pm-9:15 pm

1 stop5h 15m

Des Moines

sáb. 1/3

5:35 pm-11:32 pm

1 stop4h 57m

$277

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

mar. 11/25

9:47 am-1:32 pm

1 stop4h 45m

Des Moines

sáb. 11/29

6:17 am-11:59 am

1 stop4h 42m

$277

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

jue. 10/30

7:00 am-10:45 am

1 stop4h 45m

Des Moines

mar. 11/4

3:39 pm-12:15 am

1 stop7h 36m

$285

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

jue. 10/30

5:30 am-10:05 am

1 stop5h 35m

Des Moines

mar. 11/4

7:20 am-2:30 pm

1 stop6h 10m

$285

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

mar. 10/14

8:04 pm-12:02 am

1 stop4h 58m

Des Moines

vie. 10/17

6:22 pm-11:51 pm

1 stop4h 29m

$287

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

vie. 10/10

7:20 am-8:29 am

1 stop26h 09m

Des Moines

dom. 10/12

10:41 am-11:28 pm

1 stop11h 47m

$291

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Showing 1-10 of 50 results
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Best time to book a flight from South Carolina to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Des Moines

What is the cheapest month to book a flight from South Carolina to Des Moines?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $336). Flying from South Carolina to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to DSM?

Find hourly flight availability from South Carolina to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 19, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Des Moines as you normally would.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from South Carolina?

    Des Moines (DSM) is the airport you will fly into if you book a flight from South Carolina to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • How long is the flight from South Carolina to Des Moines?

    Delta, American Airlines, and Southwest can get you from South Carolina to Des Moines in just under 4h 45m. Your travel time can differ by up to 6h 45m. South Carolina and Des Moines are separated by a distance of 771 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Des Moines one-way?

    One-way options have recently been found by users for as low as $123 on Frontier. Other airlines that offer cheap prices include Delta from $129 and American Airlines from $149 one-way.

  • What are the most popular routes from South Carolina to Des Moines?

    When deciding which route to take from South Carolina to Des Moines consider Charlotte Douglas - Des Moines, Charleston - Des Moines or Savannah/Hilton Head - Des Moines as they are the most popular.

  • Can I find deals for flights from South Carolina to Des Moines that include hotel bookings?

    Yes. In addition to deals on South Carolina to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Des Moines.

  • Can I find deals for business class flights from South Carolina to Des Moines?

    Yes. Cheapflights offers flight deals from South Carolina to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $336). Flying from South Carolina to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for South Carolina to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Des Moines

Discover the top 3 airlines that operate flights from South Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 19, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$381FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$401FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$366Average$626FlexibilityNo cancel feeOn-time69%

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