$114+ Cheap flights from South Carolina to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/11. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from South Carolina to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Des Moines
Keep the following information in mind while searching for South Carolina to Des Moines flight deals. Data was last updated June 12, 2025.
Round-trip from | $178 (Mytrip) |
|---|---|
One-way from | $114 (Mytrip) |
Find flight deals from South Carolina to Des Moines
Cheapest flights from South Carolina to Des MoinesExplore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.
Explore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.
This Mytrip deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
CharlotteDes Moines
CLT - DSM
CLTDSM
Charlotte Douglas
Fri 7/18
9:24 am-6:06 pm
1 stop9h 42m
Des Moines
Sun 7/20
6:32 pm-2:02 pm
1 stop18h 30m
CharlotteDes Moines
CLT - DSM
CLTDSM
Charlotte Douglas
Wed 8/13
8:25 am-1:27 pm
1 stop6h 02m
Des Moines
Sat 8/16
5:44 am-10:41 am
1 stop3h 57m
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Thu 7/17
10:53 am-2:45 pm
2 stops28h 52m
Des Moines
Sun 7/20
6:32 pm-2:45 pm
2 stops19h 13m
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Sat 9/13
6:45 am-10:18 am
1 stop4h 33m
Des Moines
Sat 9/27
5:45 am-1:08 pm
1 stop6h 23m
GreenvilleDes Moines
GSP - DSM
GSPDSM
Greenville
Sat 9/13
8:05 am-3:33 pm
2 stops8h 28m
Des Moines
Sat 9/27
9:34 am-4:57 pm
1 stop6h 23m
Myrtle BeachDes Moines
MYR - DSM
MYRDSM
Myrtle Beach Intl
Thu 7/24
7:34 pm-12:46 pm
1 stop18h 12m
Des Moines
Sun 7/27
6:32 pm-10:17 pm
2 stops26h 45m
ColumbiaDes Moines
CAE - DSM
CAEDSM
Columbia Metropolitan
Thu 8/21
8:44 pm-11:45 pm
1 stop4h 01m
Des Moines
Sun 8/24
7:14 am-3:20 pm
1 stop7h 06m
ColumbiaDes Moines
CAE - DSM
CAEDSM
Columbia Metropolitan
Fri 9/12
11:55 am-5:39 pm
1 stop6h 44m
Des Moines
Sun 9/14
5:45 am-12:28 pm
1 stop5h 43m
ColumbiaDes Moines
CAE - DSM
CAEDSM
Columbia Metropolitan
Sat 6/28
5:41 pm-10:37 pm
2 stops29h 56m
Des Moines
Mon 6/30
8:35 am-1:53 pm
1 stop28h 18m
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Sun 9/14
6:05 am-10:39 am
1 stop5h 34m
Des Moines
Wed 9/17
1:10 pm-7:08 pm
1 stop4h 58m
Best time to book a flight from South Carolina to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from South Carolina with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Des Moines
What is the cheapest month to book a flight from South Carolina to Des Moines?
Currently, August is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $336). Flying from South Carolina to Des Moines in June is currently the most expensive (average of $411). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to DSM?
Find hourly flight availability from South Carolina to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Des Moines as you normally would.
Rainfall in Des Moines by month
Plan your trip to Des Moines by taking into account the average rainfall totals by month.
In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.
Temperature in Des Moines by month
Plan your trip to Des Moines by taking into account the average temperature totals by month.
If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated June 12, 2025.
See what other customers who have flown with Southwest, Delta and United Airlines from South Carolina to Des Moines have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
Overall
Food
Comfort
Entertainment
Boarding
Reviews
John,May 2025
PVD - BNA
Crew
Overall
Food
Comfort
Entertainment
Boarding
Reviews
John,May 2025
PVD - BNA
Crew
Overall
Food
Comfort
Entertainment
Boarding
Reviews
John,May 2025
PVD - BNA
Crew
Overall
Food
Comfort
Entertainment
Boarding
Reviews
John,May 2025
PVD - BNA
Crew
Overall
Food
Comfort
Entertainment
Boarding
Reviews
John,May 2025
PVD - BNA
Crew
Overall
Food
Comfort
Entertainment
Boarding
Reviews
John,May 2025
PVD - BNA
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Des Moines
See prices for flight routes from nearby airports that may be better suited for you.
Top 2 airlines flying from South Carolina to Des Moines
Discover the top 2 airlines that operate flights from South Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$188 | Average$423 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$242 | Average$377 | FlexibilityNo cancel fee | On-timeN/A |