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Des Moines

$89+ Cheap flights from South Carolina to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/9. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Mar 13 — Mar 201
Fri 3/13
Fri 3/20
1 adult, Economy
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Cheap flight deals from South Carolina to Des Moines

Cheapest flights from South Carolina to Des Moines
Explore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/13:29 pm
MYR
-
DSM
1 stop23h 17m
Multiple Airlines
Sun 4/57:00 am
DSM
-
MYR
1 stop12h 48m
Multiple Airlines
Deal found 2/9$251
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/511:00 am
CLT
-
DSM
1 stop12h 51m
Multiple Airlines
Sun 3/87:00 am
DSM
-
CLT
2 stops24h 26m
Multiple Airlines
Deal found 2/10$262
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:48 am
CAE
-
DSM
1 stop7h 30m
American Airlines
Mon 3/97:45 am
DSM
-
CAE
1 stop8h 10m
American Airlines
Deal found 2/10$269
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/287:00 am
CAE
-
DSM
1 stop5h 56m
American Airlines
Mon 3/27:45 am
DSM
-
CAE
1 stop8h 10m
American Airlines
Deal found 2/9$274
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:48 am
CAE
-
DSM
1 stop7h 30m
American Airlines
Sat 2/282:02 pm
DSM
-
CAE
1 stop6h 53m
American Airlines
Deal found 2/9$279
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/266:00 am
CLT
-
DSM
1 stop8h 29m
Multiple Airlines
Sun 3/293:22 pm
DSM
-
CLT
2 stops39h 59m
Multiple Airlines
Deal found 2/10$281
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1911:00 am
CLT
-
DSM
1 stop13h 12m
Multiple Airlines
Mon 2/238:38 pm
DSM
-
CLT
2 stops16h 13m
Multiple Airlines
Deal found 2/10$287
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:00 am
CHS
-
DSM
1 stop16h 06m
Multiple Airlines
Sun 5/32:36 pm
DSM
-
CHS
1 stop7h 05m
Multiple Airlines
Deal found 2/8$290
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/235:05 pm
CLT
-
DSM
1 stop6h 25m
Southwest
Tue 2/246:10 am
DSM
-
CLT
2 stops5h 30m
Southwest
Deal found 2/9$308
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:56 am
CLT
-
DSM
2 stops14h 46m
Multiple Airlines
Sun 4/268:30 am
DSM
-
CLT
1 stop15h 10m
Multiple Airlines
Deal found 2/10$313
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/178:15 am
CHS
-
DSM
1 stop6h 08m
United Airlines
Tue 3/242:04 pm
DSM
-
CHS
1 stop6h 12m
United Airlines
Deal found 2/9$317
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/911:40 am
GSP
-
DSM
1 stop6h 08m
Delta
Tue 5/122:33 pm
DSM
-
GSP
1 stop4h 40m
Delta
Deal found 2/9$317

Find flight deals from South Carolina to Des Moines

Keep the following information in mind while searching for South Carolina to Des Moines flight deals. Data was last updated February 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$251
(Kiwi.com)

One-way from

$89
(Trip.com)
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
Search Deals
From South Carolina to Des Moines
Search Deals
One-way flight from South Carolina to Des Moines
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.

Fly from

South Carolina

Fly to

Des Moines

Route

Depart

Return

Price

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 4/1

3:29 pm-1:46 pm

1 stop23h 17m

Des Moines

Sun 4/5

7:00 am-8:48 pm

1 stop12h 48m

$251

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Fri 3/6

6:48 am-1:18 pm

1 stop7h 30m

Des Moines

Mon 3/9

7:45 am-4:55 pm

1 stop8h 10m

$269

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Sat 2/28

7:00 am-11:56 am

1 stop5h 56m

Des Moines

Mon 3/2

7:45 am-4:55 pm

1 stop8h 10m

$274

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Tue 2/24

6:48 am-1:18 pm

1 stop7h 30m

Des Moines

Sat 2/28

2:02 pm-9:55 pm

1 stop6h 53m

$279

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 3/26

6:00 am-1:29 pm

1 stop8h 29m

Des Moines

Sun 3/29

3:22 pm-8:21 am

2 stops39h 59m

$281

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 4/30

7:00 am-10:06 pm

1 stop16h 06m

Des Moines

Sun 5/3

2:36 pm-10:41 pm

1 stop7h 05m

$290

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Tue 3/17

8:15 am-1:23 pm

1 stop6h 08m

Des Moines

Tue 3/24

2:04 pm-9:16 pm

1 stop6h 12m

$317

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 5/9

11:40 am-4:48 pm

1 stop6h 08m

Des Moines

Tue 5/12

2:33 pm-8:13 pm

1 stop4h 40m

$317

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 4/1

4:41 pm-10:43 pm

1 stop7h 02m

Des Moines

Wed 4/8

1:10 pm-8:47 pm

1 stop6h 37m

$317

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Tue 3/17

5:20 pm-9:51 pm

1 stop5h 31m

Des Moines

Tue 3/24

7:45 am-4:18 pm

1 stop7h 33m

$317

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/9

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Des Moines

What is the cheapest month to book a flight from South Carolina to Des Moines?

Currently, September is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $162). Flying from South Carolina to Des Moines in February is currently the most expensive (average of $345). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to DSM?

Find hourly flight availability from South Carolina to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 11, 2026.

It’s typically best to fly out from South Carolina to Des Moines in the afternoon. Doing so could potentially save you 40% on the flight price compared to flying in the evening, which is usually more expensive.

What is the cheapest day to fly from South Carolina to Des Moines?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Des Moines. Price data was last updated on March 30, 2025.

Travelers seeking maximum savings on their South Carolina to Des Moines flight should consider departing on Saturday afternoons when fares are most often at their lowest. Tuesday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from South Carolina?

    Des Moines (DSM) is the airport you will fly into if you book a flight from South Carolina to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • How long is the flight from South Carolina to Des Moines?

    American Airlines, United Airlines, and Delta can get you from South Carolina to Des Moines in just under 5h 56m. Your travel time can differ by up to 12m. South Carolina and Des Moines are separated by a distance of 861 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from South Carolina to Des Moines?

    When deciding which route to take from South Carolina to Des Moines consider Charlotte Douglas - Des Moines, Charleston - Des Moines or Greenville - Des Moines as they are the most popular.

  • Can I find deals for flights from South Carolina to Des Moines that include hotel bookings?

    Yes. In addition to deals on South Carolina to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Des Moines.

  • Can I find deals for business class flights from South Carolina to Des Moines?

    Yes. Cheapflights offers flight deals from South Carolina to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $162). Flying from South Carolina to Des Moines in February is currently the most expensive (average of $345). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Alternative routes for South Carolina to Des Moines

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Top 3 airlines flying from South Carolina to Des Moines

Discover the top 3 airlines that operate flights from South Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$378FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$233Average$370FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$326Average$571FlexibilityNo cancel feeOn-time69%

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