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Des Moines

$97+ Cheap flights from South Carolina to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/6. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
May 5 — May 121
Mon 5/5
Mon 5/12
1 adult, Economy
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Cheap flight deals from South Carolina to Des Moines

Keep the following information in mind while searching for South Carolina to Des Moines flight deals. Data was last updated April 30, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$213
(Mytrip)

One-way from

$97
(Mytrip)
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
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From South Carolina to Des Moines
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One-way flight from South Carolina to Des Moines
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Find flight deals from South Carolina to Des Moines

Cheapest flights from South Carolina to Des Moines
Explore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2025.

This Mytrip deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/205:33 pmCLT - DSM
1 stop24h 43mMultiple Airlines
Sun 6/226:32 pmDSM - CLT
1 stop21h 05mMultiple Airlines
Deal found 4/27$213
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/75:15 amCAE - DSM
1 stop6h 38mAmerican Airlines
Sat 8/94:23 pmDSM - CAE
1 stop4h 33mAmerican Airlines
Deal found 4/29$249
This Mytrip deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/286:00 amCHS - DSM
2 stops42h 27mMultiple Airlines
Sun 6/17:15 pmDSM - CHS
2 stops25h 54mMultiple Airlines
Deal found 4/28$281
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/67:00 amCAE - DSM
1 stop4h 41mDelta
Tue 5/137:11 amDSM - CAE
1 stop8h 07mDelta
Deal found 4/29$284
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/246:50 pmCHS - DSM
1 stop4h 40mDelta
Mon 5/262:15 pmDSM - CHS
1 stop5h 55mDelta
Deal found 4/28$287
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/75:48 pmGSP - DSM
1 stop6h 15mAmerican Airlines
Wed 8/133:48 pmDSM - GSP
1 stop5h 01mAmerican Airlines
Deal found 4/29$287
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/277:54 pmMYR - DSM
1 stop5h 04mAmerican Airlines
Sat 5/315:50 amDSM - MYR
2 stops8h 38mAmerican Airlines
Deal found 4/29$289
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/246:34 amCHS - DSM
2 stops8h 14mAmerican Airlines
Mon 5/265:32 amDSM - CHS
2 stops7h 48mAmerican Airlines
Deal found 4/28$321
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/57:02 pmSAV - DSM
1 stop6h 04mAmerican Airlines
Sun 6/85:32 pmDSM - SAV
1 stop5h 20mAmerican Airlines
Deal found 4/29$335
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/75:30 amCLT - DSM
1 stop5h 44mDelta
Mon 9/82:14 pmDSM - CLT
1 stop7h 06mDelta
Deal found 4/29$341
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/27:30 amGSP - DSM
1 stop4h 40mDelta
Mon 8/46:40 pmDSM - GSP
1 stop4h 19mDelta
Deal found 4/29$342
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/47:50 pmCLT - DSM
1 stop4h 00mSouthwest
Mon 9/87:00 amDSM - CLT
1 stop7h 15mSouthwest
Deal found 4/28$345

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.

Fly from

South Carolina

Fly to

Des Moines

Route

Depart

Return

Price

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Fri 6/20

5:33 pm-5:16 pm

1 stop24h 43m

Des Moines

Sun 6/22

6:32 pm-4:37 pm

1 stop21h 05m

$213

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Thu 8/7

5:15 am-10:53 am

1 stop6h 38m

Des Moines

Sat 8/9

4:23 pm-9:56 pm

1 stop4h 33m

$249

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 5/28

6:00 am-11:27 pm

2 stops42h 27m

Des Moines

Sun 6/1

7:15 pm-10:09 pm

2 stops25h 54m

$281

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Sat 5/24

6:50 pm-10:30 pm

1 stop4h 40m

Des Moines

Mon 5/26

2:15 pm-9:10 pm

1 stop5h 55m

$287

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 8/7

5:48 pm-11:03 pm

1 stop6h 15m

Des Moines

Wed 8/13

3:48 pm-9:49 pm

1 stop5h 01m

$287

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Tue 5/27

7:54 pm-11:58 pm

1 stop5h 04m

Des Moines

Sat 5/31

5:50 am-3:28 pm

2 stops8h 38m

$289

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Thu 8/7

7:11 pm-10:58 pm

1 stop4h 47m

Des Moines

Sat 8/9

10:56 am-7:04 pm

2 stops7h 08m

$301

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Sat 5/24

6:34 am-1:48 pm

2 stops8h 14m

Des Moines

Mon 5/26

5:32 am-2:20 pm

2 stops7h 48m

$321

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

Thu 6/5

7:02 pm-12:06 am

1 stop6h 04m

Des Moines

Sun 6/8

5:32 pm-11:52 pm

1 stop5h 20m

$335

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 8/2

7:30 am-11:10 am

1 stop4h 40m

Des Moines

Mon 8/4

6:40 pm-11:59 pm

1 stop4h 19m

$342

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Showing 1-10 of 37 results
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Best time to book a flight from South Carolina to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Des Moines

What is the cheapest month to book a flight from South Carolina to Des Moines?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $336). Flying from South Carolina to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to DSM?

Find hourly flight availability from South Carolina to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 30, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Des Moines as you normally would.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 30, 2025.
See what other customers who have flown with Southwest, Delta and United Airlines from South Carolina to Des Moines have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,295 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.6

Overall

8.0

Boarding

8.2

Food

7.1

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,295 reviews
Southwest
8.0
Very good
4,295 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.6

Overall

8.0

Boarding

8.2

Food

7.1

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,929 reviews
Southwest
8.0
Very good
4,295 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.6

Overall

8.0

Boarding

8.2

Food

7.1

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,696 reviews
Southwest
8.0
Very good
4,295 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.6

Overall

8.0

Boarding

8.2

Food

7.1

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,295 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.6

Overall

8.0

Boarding

8.2

Food

7.1

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from South Carolina?

    Des Moines (DSM) is the airport you will fly into if you book a flight from South Carolina to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • What are the cheapest airlines to fly from South Carolina to Des Moines one-way?

    One-way options have recently been found by users for as low as $136 on American Airlines. Other airlines that offer cheap prices include Delta from $141 and Southwest from $159 one-way.

  • What are the most popular routes from South Carolina to Des Moines?

    When deciding which route to take from South Carolina to Des Moines consider Charlotte Douglas - Des Moines, Columbia Metropolitan - Des Moines or Savannah/Hilton Head - Des Moines as they are the most popular.

  • Can I find deals for flights from South Carolina to Des Moines that include hotel bookings?

    Yes. In addition to deals on South Carolina to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Des Moines.

  • Can I find deals for business class flights from South Carolina to Des Moines?

    Yes. Cheapflights offers flight deals from South Carolina to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $336). Flying from South Carolina to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Ames
Altoona
Johnston
Boone
West Des Moines
Ankeny

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Alternative routes for South Carolina to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Des Moines

Discover the top 2 airlines that operate flights from South Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$188Average$468FlexibilityNo cancel feeOn-time71%
DeltaCheapest$198Average$403FlexibilityNo cancel feeOn-timeN/A

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