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Des Moines

$100+ Cheap flights from South Carolina to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
ene. 25 — feb. 11
dom. 1/25
dom. 2/1
1 adult, Economy
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Cheap flight deals from South Carolina to Des Moines

Cheapest flights from South Carolina to Des Moines
Explore the most affordable flight options available from South Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 26, 2025.

This Frontier deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/2612:17 pmCLT - DSM
1 stop8h 27mFrontier
dom. 12/2810:17 amDSM - CLT
1 stop9h 21mFrontier
Deal found 12/24$462
This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/2611:49 amCLT - DSM
Nonstop2h 32mAmerican Airlines
dom. 12/286:26 pmDSM - CLT
Nonstop2h 25mAmerican Airlines
Deal found 12/24$601
This United Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/262:54 pmCLT - DSM
2 stops10h 04mUnited Airlines
dom. 12/283:14 pmDSM - CLT
1 stop5h 06mUnited Airlines
Deal found 12/24$626
This United Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/245:36 pmGSP - DSM
1 stop5h 04mUnited Airlines
sáb. 12/273:00 pmDSM - GSP
1 stop5h 57mUnited Airlines
Deal found 12/24$645
This Kiwi.com deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/257:32 pmMYR - DSM
2 stops23h 54mMultiple Airlines
dom. 12/287:30 pmDSM - MYR
1 stop21h 38mMultiple Airlines
Deal found 12/24$713
This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/2412:48 pmMYR - DSM
1 stop6h 23mAmerican Airlines
dom. 12/286:26 pmDSM - MYR
1 stop4h 29mAmerican Airlines
Deal found 12/24$747
This Southwest deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/242:55 pmMYR - DSM
2 stops7h 40mSouthwest
dom. 12/286:35 amDSM - MYR
2 stops12h 00mSouthwest
Deal found 12/24$757
This Southwest deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/265:40 pmCLT - DSM
2 stops7h 25mSouthwest
dom. 12/286:35 amDSM - CLT
2 stops11h 55mSouthwest
Deal found 12/24$767

Find flight deals from South Carolina to Des Moines

Keep the following information in mind while searching for South Carolina to Des Moines flight deals. Data was last updated diciembre 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$269
(American Airlines)

One-way from

$100
(Kiwi.com)
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
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From South Carolina to Des Moines
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One-way flight from South Carolina to Des Moines
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Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 26, 2025.
Use the filters below to find and compare flights from South Carolina to Des Moines that are best for you.

Fly from

South Carolina

Fly to

Des Moines

Route

Depart

Return

Price

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

vie. 1/30

8:00 am-2:33 pm

1 stop7h 33m

Des Moines

dom. 2/1

3:35 pm-9:21 pm

1 stop4h 46m

$269

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

vie. 2/13

10:15 am-4:57 pm

2 stops7h 42m

Des Moines

mar. 2/17

6:19 am-4:21 pm

2 stops9h 02m

$329

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

jue. 1/22

6:30 am-2:22 pm

1 stop8h 52m

Des Moines

sáb. 1/24

7:50 am-2:02 pm

1 stop5h 12m

$329

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

jue. 1/22

1:45 pm-7:20 pm

1 stop6h 35m

Des Moines

sáb. 1/24

6:45 am-6:40 pm

2 stops10h 55m

$334

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

jue. 1/8

1:24 pm-10:46 pm

1 stop10h 22m

Des Moines

sáb. 1/10

5:58 pm-8:05 am

2 stops37h 07m

$339

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

vie. 1/9

5:07 pm-9:50 pm

1 stop5h 43m

Des Moines

mar. 1/13

1:35 pm-11:44 pm

2 stops9h 09m

$354

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

sáb. 2/14

6:00 am-10:53 am

1 stop5h 53m

Des Moines

mié. 2/18

3:24 pm-9:27 pm

1 stop5h 03m

$363

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

sáb. 2/14

4:50 pm-9:41 pm

1 stop5h 51m

Des Moines

mié. 2/18

8:00 am-7:23 pm

2 stops10h 23m

$368

AugustaDes Moines

AGS - DSM

AGSDSM

Augusta Bush Field

mié. 1/28

7:09 pm-11:08 pm

1 stop4h 59m

Des Moines

dom. 2/1

1:16 pm-9:37 pm

1 stop7h 21m

$373

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

lun. 1/26

8:25 am-11:25 am

1 stop4h 00m

Des Moines

mié. 1/28

8:35 am-6:30 pm

1 stop8h 55m

$374

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/24

Showing 1-10 of 46 results
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Best time to book a flight from South Carolina to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Des Moines

What is the cheapest month to book a flight from South Carolina to Des Moines?

Currently, September is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $162). Flying from South Carolina to Des Moines in April is currently the most expensive (average of $334). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to DSM?

Find hourly flight availability from South Carolina to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 26, 2025.

It’s typically best to fly out from South Carolina to Des Moines in the afternoon. Doing so could potentially save you 16% on the flight price compared to flying in the morning, which is usually more expensive.

What is the cheapest day to fly from South Carolina to Des Moines?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Des Moines. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to Des Moines flight should consider departing on Saturday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from South Carolina?

    Des Moines (DSM) is the airport you will fly into if you book a flight from South Carolina to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • How long is the flight from South Carolina to Des Moines?

    American Airlines, United Airlines, and Delta can get you from South Carolina to Des Moines in just under 7h 42m. Your travel time can differ by up to 1h 10m. South Carolina and Des Moines are separated by a distance of 861 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Des Moines one-way?

    One-way options have recently been found by users for as low as $203 on United Airlines. Other airlines that offer cheap prices include American Airlines from $217 and Delta from $257 one-way.

  • What are the most popular routes from South Carolina to Des Moines?

    When deciding which route to take from South Carolina to Des Moines consider Charlotte Douglas - Des Moines, Columbia Metropolitan - Des Moines or Savannah/Hilton Head - Des Moines as they are the most popular.

  • Can I find deals for flights from South Carolina to Des Moines that include hotel bookings?

    Yes. In addition to deals on South Carolina to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Des Moines.

  • Can I find deals for business class flights from South Carolina to Des Moines?

    Yes. Cheapflights offers flight deals from South Carolina to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to Des Moines (average of $162). Flying from South Carolina to Des Moines in April is currently the most expensive (average of $334). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Alternative routes for South Carolina to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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LaGuardia to Des Moines flights
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Santa Ana to Omaha flights
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Hobby to Moline flights
Portland to Cedar Rapids flights
Detroit to Omaha flights
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Portland to Des Moines flights

Top 3 airlines flying from South Carolina to Des Moines

Discover the top 3 airlines that operate flights from South Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$378FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$233Average$376FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$326Average$571FlexibilityNo cancel feeOn-time69%

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