South Carolina

$112+ Cheap flights from Iowa to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
jul. 31 — ago. 71
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Cheap flight deals from Iowa to South Carolina

Cheapest flights from Iowa to South Carolina
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 1, 2026.

This Delta deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/85:00 pm
MLI
-
CLT
1 stop5h 53m
Delta
jue. 10/156:45 am
CLT
-
MLI
1 stop4h 41m
Delta
Deal found 6/26$257
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/106:24 pm
CID
-
CLT
1 stop25h 49m
Multiple Airlines
jue. 8/136:41 pm
CLT
-
CID
1 stop23h 53m
Multiple Airlines
Deal found 6/28$257
This American Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/141:37 pm
CID
-
MYR
1 stop4h 52m
American Airlines
mié. 10/218:14 pm
MYR
-
CID
1 stop4h 44m
American Airlines
Deal found 6/29$261
This Delta deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/86:26 am
OMA
-
CLT
1 stop4h 49m
Delta
mar. 9/157:16 pm
CLT
-
OMA
1 stop4h 36m
Delta
Deal found 6/26$273
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/225:50 am
CID
-
MYR
1 stop6h 10m
Delta
mié. 8/57:02 pm
MYR
-
CID
1 stop4h 21m
Delta
Deal found 6/30$285
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/1210:49 am
CID
-
CHS
1 stop20h 49m
Multiple Airlines
jue. 8/137:47 pm
CHS
-
CID
1 stop22h 47m
Multiple Airlines
Deal found 6/30$286
This Delta deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/86:00 am
DSM
-
CLT
1 stop5h 17m
Delta
sáb. 8/1511:50 am
CLT
-
DSM
1 stop4h 26m
Delta
Deal found 6/26$287
This United Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/216:00 am
CID
-
MYR
1 stop7h 53m
United Airlines
mié. 8/2610:23 am
MYR
-
CID
2 stops11h 56m
United Airlines
Deal found 6/27$290
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/510:49 am
CID
-
CHS
1 stop20h 49m
Multiple Airlines
mar. 8/113:13 pm
CHS
-
CID
1 stop19h 46m
Multiple Airlines
Deal found 6/29$292
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/106:07 pm
DSM
-
CLT
1 stop26h 06m
Multiple Airlines
mié. 8/126:41 pm
CLT
-
DSM
2 stops29h 38m
Multiple Airlines
Deal found 6/26$292
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/146:07 pm
DSM
-
CLT
1 stop26h 06m
Multiple Airlines
dom. 9/139:22 am
CLT
-
DSM
1 stop11h 35m
Multiple Airlines
Deal found 6/26$304
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/125:40 am
DSM
-
MYR
1 stop6h 53m
Delta
mié. 8/196:00 am
MYR
-
DSM
1 stop5h 43m
Delta
Deal found 6/29$307

Find flight deals from Iowa to South Carolina

Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated julio 1, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$257
(Delta)

One-way from

$112
(Kiwi.com)

Popular in

July

Cheapest in

January

Average price

$486
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
From Iowa to South Carolina
One-way flight from Iowa to South Carolina
Highest demand for flights based on searches. 4% potential increase in price ($16 potential increase over avg. RT price).
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Average for round-trip flights in July 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 1, 2026.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MolineCharlotte

MLI - CLT

MLICLT

Moline Quad-City

mar. 8/25

6:00 am-11:03 am

1 stop4h 03m

Charlotte Douglas

lun. 8/31

11:50 am-4:25 pm

1 stop5h 35m

$257

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

mié. 7/22

5:50 am-1:00 pm

1 stop6h 10m

Myrtle Beach Intl

mié. 8/5

7:02 pm-10:23 pm

1 stop4h 21m

$285

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

sáb. 9/5

4:11 pm-11:57 pm

1 stop6h 46m

Charlotte Douglas

mar. 9/8

6:20 am-10:17 am

1 stop4h 57m

$287

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

mar. 9/1

7:15 am-7:10 pm

2 stops10h 55m

Myrtle Beach Intl

mié. 9/9

11:00 am-9:00 pm

2 stops11h 00m

$317

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

sáb. 11/7

11:27 am-5:14 pm

1 stop4h 47m

Charleston

mar. 11/10

9:30 am-1:27 pm

1 stop4h 57m

$317

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

mié. 8/5

6:30 am-2:27 pm

2 stops6h 57m

Charleston

mar. 8/11

10:19 am-9:19 pm

2 stops12h 00m

$319

OmahaCharlotte

OMA - CLT

OMACLT

Omaha Eppley Airfield

mar. 8/18

3:05 pm-9:10 pm

1 stop5h 05m

Charlotte Douglas

mié. 8/19

12:35 pm-7:20 pm

1 stop7h 45m

$321

OmahaCharlotte

OMA - CLT

OMACLT

Omaha Eppley Airfield

lun. 9/28

2:15 pm-9:50 pm

1 stop6h 35m

Charlotte Douglas

mié. 9/30

8:05 am-11:40 am

1 stop4h 35m

$323

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

vie. 10/16

5:45 am-11:26 am

1 stop4h 41m

Charleston

mié. 10/21

5:55 pm-9:51 pm

1 stop4h 56m

$324

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

sáb. 7/18

5:45 am-1:43 pm

1 stop6h 58m

Charleston

sáb. 7/25

5:00 pm-10:03 pm

1 stop6h 03m

$324

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/27

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Iowa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to South Carolina

What is the cheapest month to book a flight from Iowa to South Carolina?

Currently, June is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $134). Flying from Iowa to South Carolina in March is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Iowa to South Carolina?

How far ahead should I book a flight from Iowa to South Carolina?

The best time to book flights from Iowa to South Carolina is 20 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated julio 1, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Comfort

8.0

Crew

8.6

Food

7.0

Overall

7.9

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.

Comfort

8.0

Crew

8.6

Food

7.0

Overall

7.9

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.

Comfort

8.0

Crew

8.6

Food

7.0

Overall

7.9

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.

Comfort

8.0

Crew

8.6

Food

7.0

Overall

7.9

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.

Comfort

8.0

Crew

8.6

Food

7.0

Overall

7.9

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.

Related info for your journey

Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How long is the flight from Iowa to South Carolina?

    Airlines like Delta, Southwest, and United Airlines fly from Iowa to South Carolina in about 6h 10m. The time it takes to get you to your destination can typically vary by up to 4h 45m. The distance between Iowa and South Carolina is about 897 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Iowa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Iowa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to South Carolina.

  • Can I find deals for business class flights from Iowa to South Carolina?

    Yes. Cheapflights offers flight deals from Iowa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to South Carolina?

    Currently, June is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $134). Flying from Iowa to South Carolina in March is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Iowa to South Carolina

Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 1, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$242Average$421FlexibilityNo cancel feeOn-time71%
DeltaCheapest$243Average$425FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$460FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$272Average$406FlexibilityNo cancel feeOn-time63%

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