South Carolina

$106+ Cheap flights from Iowa to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Jun 12 — Jun 191
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Cheap flight deals from Iowa to South Carolina

Cheapest flights from Iowa to South Carolina
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 13, 2026.

This Booking.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/88:24 pm
CID
-
CLT
1 stop20h 54m
Frontier
Wed 8/1210:14 pm
CLT
-
CID
1 stop16h 00m
Frontier
Deal found 5/12$222
This Booking.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:05 pm
OMA
-
CLT
1 stop21h 13m
Frontier
Fri 8/710:14 pm
CLT
-
OMA
1 stop22h 06m
Frontier
Deal found 5/13$222
This TravelUp deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure TravelUp is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/118:15 pm
OMA
-
CLT
1 stop24h 10m
Frontier
Wed 6/1710:14 pm
CLT
-
OMA
1 stop22h 16m
Frontier
Deal found 5/11$232
This Booking.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:56 pm
OMA
-
CLT
1 stop21h 23m
Frontier
Sat 6/1310:14 pm
CLT
-
OMA
1 stop22h 16m
Frontier
Deal found 5/12$236
This Booking.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:16 pm
CID
-
CLT
1 stop21h 03m
Frontier
Mon 9/710:14 pm
CLT
-
CID
1 stop15h 56m
Frontier
Deal found 5/12$242
This Booking.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/68:05 pm
OMA
-
CLT
1 stop21h 13m
Frontier
Thu 7/97:14 pm
CLT
-
OMA
1 stop25h 06m
Frontier
Deal found 5/12$242
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:45 am
CID
-
MYR
1 stop3h 59m
Delta
Sat 7/44:17 pm
MYR
-
CID
1 stop6h 49m
Delta
Deal found 5/11$261
This Booking.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:56 pm
OMA
-
CLT
1 stop21h 23m
Frontier
Mon 6/2210:14 pm
CLT
-
OMA
1 stop22h 16m
Frontier
Deal found 5/8$262
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:00 am
CID
-
MYR
2 stops8h 32m
American Airlines
Wed 7/14:17 pm
MYR
-
CID
1 stop6h 46m
American Airlines
Deal found 5/12$266
This Booking.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/228:15 pm
OMA
-
CLT
1 stop21h 04m
Frontier
Fri 6/2610:14 pm
CLT
-
OMA
1 stop22h 16m
Frontier
Deal found 5/13$277
This CheapOair deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
-
CLT
1 stop27h 02m
Frontier
Thu 6/47:14 pm
CLT
-
DSM
1 stop19h 17m
Frontier
Deal found 5/9$280
This Booking.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/28:05 pm
OMA
-
CLT
1 stop24h 18m
Frontier
Thu 8/67:14 pm
CLT
-
OMA
1 stop25h 06m
Frontier
Deal found 5/11$282

Find flight deals from Iowa to South Carolina

Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated May 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$222
(Booking.com)

One-way from

$106
(Booking.com)

Popular in

June

Cheapest in

January

Average price

$442
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
From Iowa to South Carolina
One-way flight from Iowa to South Carolina
Highest demand for flights based on searches. 12% potential increase in price ($57 potential increase over avg. RT price).
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Average for round-trip flights in May 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 13, 2026.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

Tue 6/30

5:45 am-10:44 am

1 stop3h 59m

Myrtle Beach Intl

Sat 7/4

4:17 pm-10:06 pm

1 stop6h 49m

$261

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

Tue 8/11

6:00 am-1:33 pm

1 stop6h 33m

Myrtle Beach Intl

Tue 8/25

11:33 am-10:12 pm

2 stops11h 39m

$266

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

Tue 6/23

6:00 am-3:32 pm

2 stops8h 32m

Myrtle Beach Intl

Wed 7/1

4:17 pm-11:51 pm

2 stops8h 34m

$271

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

Sat 8/15

5:00 am-11:38 am

1 stop5h 38m

Myrtle Beach Intl

Wed 8/19

5:15 pm-10:53 pm

1 stop6h 38m

$304

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

Fri 7/24

12:09 pm-11:55 pm

2 stops10h 46m

Myrtle Beach Intl

Wed 7/29

4:16 pm-10:06 pm

1 stop6h 50m

$325

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

Wed 10/14

5:45 am-1:35 pm

1 stop6h 50m

Myrtle Beach Intl

Wed 10/21

11:10 am-9:51 pm

2 stops11h 41m

$341

OmahaMyrtle Beach

OMA - MYR

OMAMYR

Omaha Eppley Airfield

Wed 6/17

6:33 pm-11:59 pm

1 stop4h 26m

Myrtle Beach Intl

Mon 6/22

4:17 pm-8:54 pm

1 stop5h 37m

$349

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 6/9

11:28 am-7:07 pm

1 stop6h 39m

Myrtle Beach Intl

Tue 6/16

6:00 am-10:43 am

1 stop5h 43m

$351

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 6/17

6:39 pm-11:59 pm

1 stop4h 20m

Myrtle Beach Intl

Tue 6/23

6:00 am-10:43 am

1 stop5h 43m

$351

MolineCharlotte

MLI - CLT

MLICLT

Moline Quad-City

Sat 8/8

6:00 am-1:10 pm

1 stop6h 10m

Charlotte Douglas

Wed 8/12

5:30 am-10:25 am

1 stop5h 55m

$353

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/11

Showing 1-10 of 60 resultsSorted by cheapest first
1
2
3
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6

Best time to book a flight from Iowa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to South Carolina

How far ahead should I book a flight from Iowa to South Carolina?

The best time to book flights from Iowa to South Carolina is 60 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Iowa to South Carolina?

Currently, November is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $118). Flying from Iowa to South Carolina in March is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Iowa to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated May 13, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Food

7.0

Boarding

8.1

Entertainment

7.5

Crew

8.6

Comfort

8.0

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Food

7.0

Boarding

8.1

Entertainment

7.5

Crew

8.6

Comfort

8.0

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Food

7.0

Boarding

8.1

Entertainment

7.5

Crew

8.6

Comfort

8.0

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Food

7.0

Boarding

8.1

Entertainment

7.5

Crew

8.6

Comfort

8.0

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Food

7.0

Boarding

8.1

Entertainment

7.5

Crew

8.6

Comfort

8.0

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How long is the flight from Iowa to South Carolina?

    Airlines like Delta, American Airlines, and Southwest fly from Iowa to South Carolina in about 3h 59m. The time it takes to get you to your destination can typically vary by up to 4h 33m. The distance between Iowa and South Carolina is about 897 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Iowa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Iowa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to South Carolina.

  • Can I find deals for business class flights from Iowa to South Carolina?

    Yes. Cheapflights offers flight deals from Iowa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to South Carolina?

    Currently, November is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $118). Flying from Iowa to South Carolina in March is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Iowa to South Carolina

Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$237Average$414FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$242Average$401FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$431FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$272Average$406FlexibilityNo cancel feeOn-time63%

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