$71+ Cheap flights from Iowa to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/4. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
May 19 — May 261
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to South Carolina
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Cheapest flights from Iowa to South CarolinaExplore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 19, 2026.
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:45 pm
CID
- CLT
1 stop18h 26m
Multiple Airlines
Thu 5/79:07 pm
CLT
- CID
1 stop21h 48m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:45 pm
CID
- CLT
1 stop18h 26m
Multiple Airlines
Thu 5/216:41 pm
CLT
- CID
1 stop23h 40m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:45 pm
CID
- CLT
1 stop18h 26m
Multiple Airlines
Fri 5/226:00 am
CLT
- CID
1 stop12h 21m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:11 pm
CID
- CLT
1 stop19h 00m
Multiple Airlines
Thu 6/46:41 pm
CLT
- CID
1 stop23h 28m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:45 pm
CID
- CLT
1 stop16h 20m
Multiple Airlines
Fri 5/156:00 am
CLT
- CID
1 stop12h 55m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:45 pm
CID
- CLT
1 stop13h 25m
Multiple Airlines
Fri 5/156:00 am
CLT
- CID
1 stop12h 55m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:37 pm
DSM
- CLT
1 stop17h 26m
Multiple Airlines
Sun 6/71:00 pm
CLT
- DSM
1 stop10h 52m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/13:57 pm
DSM
- CLT
1 stop19h 08m
Multiple Airlines
Wed 6/37:58 pm
CLT
- DSM
1 stop13h 39m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$234
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:45 pm
CID
- CLT
1 stop18h 26m
Multiple Airlines
Sun 5/249:07 pm
CLT
- CID
1 stop21h 14m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:02 pm
DSM
- CLT
1 stop16h 01m
Multiple Airlines
Wed 6/103:16 pm
CLT
- DSM
2 stops31h 11m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:55 pm
CID
- CLT
1 stop17h 19m
Multiple Airlines
Thu 7/99:48 pm
CLT
- CID
1 stop20h 17m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:33 pm
DSM
- CLT
2 stops18h 38m
Multiple Airlines
Wed 5/65:35 pm
CLT
- DSM
1 stop22h 40m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$251
Best flights from Iowa to South CarolinaDiscover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 19, 2026.
Discover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:45 pm
CID
- CLT
1 stop13h 25m
Multiple Airlines
Fri 5/156:00 am
CLT
- CID
1 stop12h 55m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$229
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:45 am
CID
- SAV
1 stop4h 35m
Delta
Sat 8/295:35 pm
SAV
- CID
1 stop5h 15m
Delta
Deal found 4/18![Delta logo]()
$261
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/127:54 am
CID
- SAV
1 stop5h 22m
United Airlines
Tue 6/1612:10 pm
SAV
- CID
2 stops10h 21m
United Airlines
Deal found 4/14![United Airlines logo]()
$281
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/163:50 pm
OMA
- MYR
1 stop4h 55m
Southwest
Tue 6/232:10 pm
MYR
- OMA
2 stops9h 20m
Southwest
Deal found 4/14![Southwest logo]()
$318
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/194:19 pm
OMA
- CHS
1 stop5h 17m
American Airlines
Wed 5/273:43 pm
CHS
- OMA
1 stop8h 43m
American Airlines
Deal found 4/18![American Airlines logo]()
$402
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:45 am
CID
- SAV
1 stop6h 25m
Delta
Tue 6/1611:31 am
SAV
- CID
2 stops11h 35m
Delta
Deal found 4/17![Delta logo]()
$296
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/298:00 am
CID
- SAV
1 stop5h 11m
United Airlines
Wed 9/28:00 am
SAV
- CID
1 stop5h 44m
United Airlines
Deal found 4/15![United Airlines logo]()
$341
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:29 pm
OMA
- MYR
1 stop4h 29m
Delta
Tue 6/26:00 am
MYR
- OMA
1 stop5h 09m
Delta
Deal found 4/15![Delta logo]()
$321
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:15 am
OMA
- SAV
1 stop4h 45m
Southwest
Wed 5/135:00 pm
SAV
- OMA
1 stop6h 20m
Southwest
Deal found 4/16![Southwest logo]()
$354
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:15 am
OMA
- CHS
1 stop8h 56m
United Airlines
Tue 5/196:53 pm
CHS
- OMA
1 stop5h 38m
United Airlines
Deal found 4/14![United Airlines logo]()
$351
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:11 pm
CID
- CLT
1 stop24h 51m
Multiple Airlines
Mon 5/255:58 pm
CLT
- CID
2 stops20h 08m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$396
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:42 am
CID
- SAV
1 stop4h 48m
Delta
Sat 5/95:29 pm
SAV
- CID
1 stop4h 45m
Delta
Deal found 4/15![Delta logo]()
$334
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/128:01 am
OMA
- SAV
1 stop6h 12m
United Airlines
Sat 5/163:35 pm
SAV
- OMA
1 stop7h 54m
United Airlines
Deal found 4/15![United Airlines logo]()
$354
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:30 am
DSM
- CHS
2 stops8h 30m
Southwest
Sun 6/73:25 pm
CHS
- DSM
2 stops9h 20m
Southwest
Deal found 4/17![Southwest logo]()
$391
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:39 pm
DSM
- MYR
1 stop4h 20m
Delta
Tue 6/166:00 am
MYR
- DSM
1 stop5h 43m
Delta
Deal found 4/14![Delta logo]()
$335
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/233:52 pm
MLI
- CLT
2 stops7h 07m
United Airlines
Tue 5/268:05 am
CLT
- MLI
1 stop5h 34m
United Airlines
Deal found 4/14![United Airlines logo]()
$358
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:35 am
DSM
- CLT
1 stop5h 00m
Southwest
Sat 6/67:50 am
CLT
- DSM
1 stop4h 45m
Southwest
Deal found 4/15![Southwest logo]()
$397
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:27 am
DSM
- MYR
1 stop6h 13m
Delta
Sat 5/166:00 am
MYR
- DSM
1 stop6h 08m
Delta
Deal found 4/16![Delta logo]()
$336
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:00 am
OMA
- SAV
2 stops8h 13m
United Airlines
Wed 5/134:55 pm
SAV
- OMA
1 stop5h 43m
United Airlines
Deal found 4/16![United Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/253:35 pm
DSM
- MYR
1 stop4h 30m
Southwest
Tue 7/287:55 am
MYR
- DSM
1 stop4h 35m
Southwest
Deal found 4/14![Southwest logo]()
$407
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:45 am
CID
- SAV
1 stop4h 52m
Delta
Sat 5/95:30 am
SAV
- CID
2 stops6h 46m
Delta
Deal found 4/14![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:55 am
OMA
- MYR
1 stop5h 20m
United Airlines
Tue 8/183:21 pm
MYR
- OMA
1 stop7h 35m
United Airlines
Deal found 4/16![United Airlines logo]()
$366
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1910:25 am
OMA
- CHS
2 stops8h 35m
Southwest
Tue 5/267:15 am
CHS
- OMA
2 stops12h 55m
Southwest
Deal found 4/18![Southwest logo]()
$412
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/611:59 am
CID
- SAV
2 stops10h 41m
Delta
Wed 6/1011:31 am
SAV
- CID
2 stops11h 35m
Delta
Deal found 4/15![Delta logo]()
$341
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:40 am
DSM
- CHS
1 stop4h 45m
Southwest
Sun 8/168:15 am
CHS
- DSM
1 stop4h 20m
Southwest
Deal found 4/18![Southwest logo]()
$417
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1111:08 am
MLI
- CLT
1 stop6h 16m
Delta
Tue 7/145:30 am
CLT
- MLI
1 stop5h 52m
Delta
Deal found 4/17![Delta logo]()
$353
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:00 am
OMA
- MYR
1 stop7h 18m
United Airlines
Wed 5/133:14 pm
MYR
- OMA
1 stop7h 24m
United Airlines
Deal found 4/14![United Airlines logo]()
$395
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:10 am
DSM
- CHS
2 stops11h 10m
Southwest
Mon 6/84:45 pm
CHS
- DSM
2 stops7h 45m
Southwest
Deal found 4/16![Southwest logo]()
$417
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:56 am
MLI
- CLT
1 stop4h 15m
Delta
Sat 6/65:35 am
CLT
- MLI
1 stop5h 45m
Delta
Deal found 4/18![Delta logo]()
$353
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:00 am
OMA
- MYR
1 stop8h 15m
United Airlines
Wed 8/123:21 pm
MYR
- OMA
1 stop7h 35m
United Airlines
Deal found 4/15![United Airlines logo]()
$395
Last-minute flights from Iowa to South CarolinaDiscover last-minute flight deals from Iowa to South Carolina. Data last updated April 19, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to South Carolina. Data last updated April 19, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:45 pm
CID
- CLT
1 stop13h 25m
Multiple Airlines
Fri 5/156:00 am
CLT
- CID
1 stop12h 55m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:45 pm
CID
- CLT
1 stop18h 09m
Multiple Airlines
Sun 5/312:50 pm
CLT
- CID
1 stop30h 05m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:45 pm
CID
- CLT
1 stop18h 26m
Multiple Airlines
Thu 5/79:07 pm
CLT
- CID
1 stop21h 48m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:45 pm
CID
- CLT
1 stop16h 20m
Multiple Airlines
Fri 5/156:00 am
CLT
- CID
1 stop12h 55m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:33 pm
DSM
- CLT
2 stops18h 38m
Multiple Airlines
Wed 5/65:35 pm
CLT
- DSM
1 stop22h 40m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:01 pm
OMA
- CLT
1 stop23h 51m
Multiple Airlines
Sat 5/91:00 pm
CLT
- OMA
2 stops31h 34m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$263
This CheapOair deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
- CLT
1 stop19h 02m
Frontier
Thu 5/75:20 pm
CLT
- DSM
1 stop21h 11m
Frontier
Deal found 4/17![Frontier logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:45 pm
CID
- CLT
1 stop18h 26m
Multiple Airlines
Thu 5/216:41 pm
CLT
- CID
1 stop23h 40m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:45 pm
CID
- CLT
1 stop18h 26m
Multiple Airlines
Fri 5/226:00 am
CLT
- CID
1 stop12h 21m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:45 pm
CID
- CLT
1 stop18h 26m
Multiple Airlines
Sun 5/249:07 pm
CLT
- CID
1 stop21h 14m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:45 pm
CID
- CLT
1 stop18h 26m
Multiple Airlines
Mon 5/256:00 am
CLT
- CID
1 stop12h 21m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$256
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/245:45 am
CID
- SAV
1 stop6h 25m
Delta
Wed 6/103:53 pm
SAV
- CID
1 stop7h 13m
Delta
Deal found 4/17![Delta logo]()
$261
One-way flights from Iowa to South CarolinaSearch for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 19, 2026.
Search for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:45 pm
CID
- CLT
1 stop16h 20m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$71
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:45 pm
CID
- CLT
1 stop18h 26m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$72
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:45 pm
CID
- CLT
1 stop18h 26m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$82
This Trip.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:36 pm
CID
- CLT
1 stop25h 20m
Frontier
Deal found 4/17![Frontier logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:04 pm
CID
- CLT
1 stop17h 10m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$102
This CheapOair deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- CLT
1 stop25h 52m
Frontier
Deal found 4/15![Frontier logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:55 pm
CID
- CLT
1 stop14h 41m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:45 am
DSM
- CLT
1 stop27h 20m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:44 pm
DSM
- CLT
1 stop16h 30m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:45 pm
CID
- CLT
1 stop16h 20m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$113
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:45 am
DSM
- CLT
1 stop27h 20m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/145:02 pm
DSM
- CLT
1 stop20h 50m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$121
Find flight deals from Iowa to South Carolina
Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated April 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $155 (Kiwi.com) |
One-way from | $71 (Kiwi.com) |
Popular in | June |
Cheapest in | January |
Average price | $417 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 19, 2026.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Cedar RapidsCharlotte
CID - CLT
CIDCLT
Cedar Rapids
Fri 5/1
6:45 pm-9:10 am
1 stop13h 25m
Charlotte Douglas
Fri 5/15
6:00 am-5:55 pm
1 stop12h 55m
$229
Cedar RapidsSavannah
CID - SAV
CIDSAV
Cedar Rapids
Sat 8/22
5:45 am-11:20 am
1 stop4h 35m
Savannah/Hilton Head
Sat 8/29
5:35 pm-9:50 pm
1 stop5h 15m
$261
Cedar RapidsSavannah
CID - SAV
CIDSAV
Cedar Rapids
Fri 6/12
7:54 am-2:16 pm
1 stop5h 22m
Savannah/Hilton Head
Tue 6/16
12:10 pm-9:31 pm
2 stops10h 21m
$281
Cedar RapidsSavannah
CID - SAV
CIDSAV
Cedar Rapids
Mon 5/25
5:45 am-1:10 pm
1 stop6h 25m
Savannah/Hilton Head
Tue 6/16
11:31 am-10:06 pm
2 stops11h 35m
$296
OmahaMyrtle Beach
OMA - MYR
OMAMYR
Omaha Eppley Airfield
Tue 6/16
3:50 pm-9:45 pm
1 stop4h 55m
Myrtle Beach Intl
Tue 6/23
2:10 pm-10:30 pm
2 stops9h 20m
$318
OmahaMyrtle Beach
OMA - MYR
OMAMYR
Omaha Eppley Airfield
Tue 5/26
6:29 pm-11:58 pm
1 stop4h 29m
Myrtle Beach Intl
Tue 6/2
6:00 am-10:09 am
1 stop5h 09m
$321
Cedar RapidsSavannah
CID - SAV
CIDSAV
Cedar Rapids
Tue 5/5
5:42 am-11:30 am
1 stop4h 48m
Savannah/Hilton Head
Sat 5/9
5:29 pm-9:14 pm
1 stop4h 45m
$334
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Tue 6/9
6:39 pm-11:59 pm
1 stop4h 20m
Myrtle Beach Intl
Tue 6/16
6:00 am-10:43 am
1 stop5h 43m
$335
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Wed 5/13
5:27 am-12:40 pm
1 stop6h 13m
Myrtle Beach Intl
Sat 5/16
6:00 am-11:08 am
1 stop6h 08m
$336
Cedar RapidsSavannah
CID - SAV
CIDSAV
Cedar Rapids
Mon 5/4
6:45 am-12:37 pm
1 stop4h 52m
Savannah/Hilton Head
Sat 5/9
5:30 am-11:16 am
2 stops6h 46m
$339
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
CID-CLT
DSM-CLT
CID-SAV
OMA-CLT
OMA-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to South Carolina
USIA-USSC
CID-CLT
DSM-CLT
CID-SAV
OMA-CLT
What is the cheapest month to book a flight from Iowa to South Carolina?
Currently, November is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $118). Flying from Iowa to South Carolina in March is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Iowa to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 19, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Iowa to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to South Carolina by cabin class
Find flights from Iowa to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and South Carolina flights
Browse other Iowa and South Carolina flight options. Last updated on April 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Iowa after your stay in South Carolina
Iowa to South Carolina flights
Consider these flights traveling from Iowa to South Carolina.
Top 4 airlines flying from Iowa to South Carolina
Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$236 | Average$422 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$242 | Average$402 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$455 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$272 | Average$397 | FlexibilityNo cancel fee | On-time63% |