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South Carolina

$82+ Cheap flights from Iowa to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
May 2 — May 91
Sat 5/2
Sat 5/9
1 adult, Economy
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Cheap flight deals from Iowa to South Carolina

Cheapest flights from Iowa to South Carolina
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2026.

This CheapOair deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
-
CLT
1 stop25h 52m
Frontier
Tue 5/55:20 pm
CLT
-
DSM
1 stop21h 11m
Frontier
Deal found 3/31$151
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:45 pm
CID
-
CLT
1 stop18h 26m
Multiple Airlines
Thu 5/216:41 pm
CLT
-
CID
1 stop23h 40m
Multiple Airlines
Deal found 4/2$202
This CheapOair deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:04 pm
DSM
-
CLT
1 stop27h 50m
Frontier
Thu 4/236:18 pm
CLT
-
DSM
1 stop19h 51m
Frontier
Deal found 3/30$212
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/145:02 pm
DSM
-
CLT
1 stop15h 55m
Multiple Airlines
Sat 6/207:13 pm
CLT
-
DSM
1 stop28h 39m
Multiple Airlines
Deal found 3/29$214
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:45 pm
CID
-
CLT
1 stop26h 13m
Multiple Airlines
Mon 5/48:56 am
CLT
-
CID
1 stop9h 59m
Multiple Airlines
Deal found 3/30$231
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:45 pm
CID
-
CLT
1 stop26h 13m
Multiple Airlines
Sun 4/267:19 pm
CLT
-
CID
1 stop14h 40m
Multiple Airlines
Deal found 3/29$234
This CheapOair deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
-
CLT
1 stop26h 58m
Frontier
Thu 6/47:14 pm
CLT
-
DSM
1 stop19h 17m
Frontier
Deal found 3/30$236
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:45 pm
CID
-
CLT
1 stop13h 25m
Multiple Airlines
Mon 4/278:56 am
CLT
-
CID
1 stop9h 59m
Multiple Airlines
Deal found 3/31$237
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:04 pm
DSM
-
CLT
2 stops19h 13m
Multiple Airlines
Thu 4/3012:50 pm
CLT
-
DSM
1 stop10h 16m
Multiple Airlines
Deal found 3/30$239
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:45 pm
CID
-
CLT
1 stop26h 13m
Multiple Airlines
Mon 5/48:56 am
CLT
-
CID
1 stop9h 59m
Multiple Airlines
Deal found 4/1$240
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/32:36 pm
DSM
-
MYR
1 stop7h 53m
Multiple Airlines
Thu 5/76:00 am
MYR
-
DSM
1 stop10h 15m
Multiple Airlines
Deal found 3/31$248
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
-
CLT
1 stop18h 22m
Multiple Airlines
Mon 6/112:29 pm
CLT
-
DSM
1 stop11h 55m
Multiple Airlines
Deal found 3/29$254

Find flight deals from Iowa to South Carolina

Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated April 2, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$151
(CheapOair)

One-way from

$82
(CheapOair)

Popular in

November

Cheapest in

January

Average price

$381
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
Search Deals
From Iowa to South Carolina
Search Deals
One-way flight from Iowa to South Carolina
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($35 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2026.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Sat 8/22

6:25 am-2:11 pm

1 stop6h 46m

Savannah/Hilton Head

Sat 8/29

3:14 pm-7:12 pm

1 stop4h 58m

$261

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Sat 8/22

5:45 am-11:20 am

1 stop4h 35m

Savannah/Hilton Head

Sat 8/29

5:35 pm-9:50 pm

1 stop5h 15m

$261

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Mon 5/4

9:46 am-5:37 pm

1 stop6h 51m

Savannah/Hilton Head

Sat 5/9

8:08 am-11:52 am

1 stop4h 44m

$276

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Mon 5/4

6:45 am-12:37 pm

1 stop4h 52m

Savannah/Hilton Head

Sat 5/9

5:30 am-11:16 am

2 stops6h 46m

$281

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Mon 4/27

8:00 am-2:40 pm

1 stop5h 40m

Savannah/Hilton Head

Tue 5/5

4:55 pm-9:38 pm

1 stop5h 43m

$295

OmahaMyrtle Beach

OMA - MYR

OMAMYR

Omaha Eppley Airfield

Tue 4/28

8:00 am-2:17 pm

1 stop5h 17m

Myrtle Beach Intl

Wed 4/29

3:15 pm-10:11 pm

1 stop7h 56m

$305

OmahaMyrtle Beach

OMA - MYR

OMAMYR

Omaha Eppley Airfield

Tue 8/25

8:20 am-4:05 pm

2 stops6h 45m

Myrtle Beach Intl

Tue 9/1

7:50 am-11:40 am

1 stop4h 50m

$310

OmahaMyrtle Beach

OMA - MYR

OMAMYR

Omaha Eppley Airfield

Tue 5/5

6:00 am-2:18 pm

1 stop7h 18m

Myrtle Beach Intl

Sat 5/9

3:14 pm-11:42 pm

2 stops9h 28m

$326

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Sat 4/18

1:28 pm-7:15 pm

1 stop4h 47m

Savannah/Hilton Head

Thu 4/23

5:04 pm-9:43 pm

1 stop5h 39m

$329

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Sat 4/18

12:34 pm-11:59 pm

2 stops10h 25m

Savannah/Hilton Head

Thu 4/23

6:49 pm-11:12 pm

1 stop5h 23m

$334

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/30

Showing 1-10 of 60 resultsSorted by cheapest first
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2
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6

Best time to book a flight from Iowa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to South Carolina

What is the cheapest month to book a flight from Iowa to South Carolina?

Currently, May is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $170). Flying from Iowa to South Carolina in March is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to SC?

Find hourly flight availability from Iowa to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 2, 2026.

One of the essential ways to save on airfare from Iowa to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 34% on airfare.

What is the cheapest day to fly from Iowa to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Iowa to South Carolina. Price data was last updated on March 30, 2025.

Travelers seeking maximum savings on their Iowa to South Carolina flight should consider departing on Monday afternoons when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Iowa to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 2, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,336 reviews

Food

7.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,336 reviews
Southwest
8.0
Very good
4,336 reviews

Food

7.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Delta
7.9
Good
8,369 reviews
Southwest
8.0
Very good
4,336 reviews

Food

7.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
United Airlines
7.4
Good
9,533 reviews
Southwest
8.0
Very good
4,336 reviews

Food

7.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,549 reviews
Southwest
8.0
Very good
4,336 reviews

Food

7.0

Boarding

8.1

Crew

8.6

Comfort

8.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to South Carolina?

    Airlines like United Airlines, Delta, and Southwest fly from Iowa to South Carolina in about 4h 35m. The time it takes to get you to your destination can typically vary by up to 2h 11m. The distance between Iowa and South Carolina is about 887 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Iowa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Iowa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to South Carolina.

  • Can I find deals for business class flights from Iowa to South Carolina?

    Yes. Cheapflights offers flight deals from Iowa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $170). Flying from Iowa to South Carolina in March is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Iowa to South Carolina

Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$148Average$392FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$421FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$411FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$272Average$397FlexibilityNo cancel feeOn-time63%

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