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South Carolina

$90+ Cheap flights from Iowa to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Iowa to South Carolina

Cheapest flights from Iowa to South Carolina
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/241:58 pmOMA - CHS
1 stop4h 34mAmerican Airlines
Thu 1/18:08 pmCHS - OMA
1 stop4h 51mAmerican Airlines
Deal found 12/16$301
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/241:58 pmOMA - CHS
1 stop4h 34mAmerican Airlines
Wed 1/1412:37 pmCHS - OMA
1 stop6h 04mAmerican Airlines
Deal found 12/16$327
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:40 amCID - SAV
1 stop5h 27mAmerican Airlines
Thu 12/256:44 amSAV - CID
1 stop5h 00mAmerican Airlines
Deal found 12/15$354
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:28 pmDSM - CHS
1 stop5h 58mAmerican Airlines
Sun 1/48:08 pmCHS - DSM
1 stop5h 29mAmerican Airlines
Deal found 12/16$368
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/258:55 amCID - CLT
1 stop9h 15mAmerican Airlines
Thu 1/111:20 amCLT - CID
1 stop13h 30mAmerican Airlines
Deal found 12/16$381
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:44 pmOMA - CHS
1 stop5h 42mAmerican Airlines
Sun 1/48:08 pmCHS - OMA
1 stop4h 51mAmerican Airlines
Deal found 12/15$384
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:20 amMLI - CLT
1 stop9h 07mAmerican Airlines
Sat 12/275:10 amCLT - MLI
1 stop6h 29mAmerican Airlines
Deal found 12/16$392
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/187:00 amMLI - CLT
Nonstop2h 25mAmerican Airlines
Sat 1/178:08 pmCLT - MLI
Nonstop2h 25mAmerican Airlines
Deal found 12/17$398
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:09 pmDSM - CHS
1 stop8h 17mAmerican Airlines
Fri 1/28:08 pmCHS - DSM
1 stop5h 29mAmerican Airlines
Deal found 12/14$403
This Priceline deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1911:24 amOMA - CLT
1 stop7h 45mFrontier
Sun 1/412:17 pmCLT - OMA
1 stop8h 57mFrontier
Deal found 12/15$407
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:52 pmDSM - CLT
1 stop12h 12mAmerican Airlines
Sat 1/311:42 amCLT - DSM
Nonstop2h 32mAmerican Airlines
Deal found 12/17$408
This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 amMLI - CLT
1 stop6h 27mDelta
Sat 1/176:59 pmCLT - MLI
1 stop4h 34mDelta
Deal found 12/17$418

Find flight deals from Iowa to South Carolina

Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$194
(Kiwi.com)

One-way from

$90
(Kiwi.com)

Popular in

June

Cheapest in

August

Average price

$373
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
Search Deals
From Iowa to South Carolina
Search Deals
One-way flight from Iowa to South Carolina
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($39 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.

Fly from

Iowa

Fly to

South Carolina

Route

Depart

Return

Price

OmahaCharlotte

OMA - CLT

OMACLT

Omaha Eppley Airfield

Fri 1/30

7:46 pm-9:55 am

1 stop13h 09m

Charlotte Douglas

Sun 2/1

9:59 pm-6:56 pm

1 stop21h 57m

$228

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Fri 1/16

5:11 pm-11:55 pm

1 stop5h 44m

Charleston

Sun 1/18

5:18 pm-10:33 pm

1 stop6h 15m

$243

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/11

2:58 pm-5:36 pm

1 stop25h 38m

Charleston

Sun 1/18

11:10 am-7:23 pm

2 stops33h 13m

$246

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 1/26

6:30 am-8:38 am

1 stop25h 08m

Charleston

Thu 1/29

6:35 pm-10:19 am

2 stops16h 44m

$252

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Sat 4/25

5:45 am-11:19 am

1 stop4h 34m

Savannah/Hilton Head

Tue 4/28

5:35 pm-9:50 pm

1 stop5h 15m

$269

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Fri 1/30

7:43 am-4:58 pm

1 stop8h 15m

Columbia Metropolitan

Fri 2/6

6:00 am-12:46 pm

1 stop7h 46m

$270

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Thu 1/1

5:43 pm-12:05 am

1 stop5h 22m

Charleston

Mon 1/5

4:49 pm-11:40 pm

1 stop7h 51m

$275

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Fri 1/16

11:28 am-9:11 pm

2 stops8h 43m

Charleston

Sun 1/18

3:16 pm-9:58 pm

1 stop7h 42m

$283

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 2/20

8:38 pm-6:02 pm

2 stops20h 24m

Charlotte Douglas

Thu 2/26

1:24 pm-11:06 pm

1 stop10h 42m

$283

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Thu 1/29

2:58 pm-5:36 pm

1 stop25h 38m

Charleston

Thu 2/5

6:35 pm-10:19 am

2 stops16h 44m

$285

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 60 results
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Best time to book a flight from Iowa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to South Carolina

What is the cheapest month to book a flight from Iowa to South Carolina?

Currently, May is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $166). Flying from Iowa to South Carolina in December is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to SC?

Find hourly flight availability from Iowa to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

One of the essential ways to save on airfare from Iowa to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 19% on airfare.

What is the cheapest day to fly from Iowa to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Iowa to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Iowa to South Carolina flight should consider departing on Monday afternoons when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Iowa to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 18, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,250 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
7.9
Good
4,250 reviews
Southwest
7.9
Good
4,250 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,005 reviews
Southwest
7.9
Good
4,250 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,091 reviews
Southwest
7.9
Good
4,250 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,054 reviews
Southwest
7.9
Good
4,250 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to South Carolina?

    Airlines like Delta, American Airlines, and United Airlines fly from Iowa to South Carolina in about 5h 38m. The time it takes to get you to your destination can typically vary by up to 2h 37m. The distance between Iowa and South Carolina is about 887 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Iowa to South Carolina one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $167. However, be on the lookout for offers from Delta and United Airlines, as they are both options that can get you from Iowa to South Carolina for a low price.

  • Can I find deals for flights from Iowa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Iowa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to South Carolina.

  • Can I find deals for business class flights from Iowa to South Carolina?

    Yes. Cheapflights offers flight deals from Iowa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $166). Flying from Iowa to South Carolina in December is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Iowa to South Carolina

Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$199Average$362FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$229Average$403FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$235Average$385FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$272Average$404FlexibilityNo cancel feeOn-time63%

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