HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$82+ Cheap flights from Iowa to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Apr 21 — Apr 281
Tue 4/21
Tue 4/28
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Iowa to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Iowa to South Carolina

Cheapest flights from Iowa to South Carolina
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 22, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:45 pm
CID
-
CLT
1 stop26h 13m
Multiple Airlines
Fri 5/19:04 am
CLT
-
CID
1 stop9h 51m
Multiple Airlines
Deal found 3/19$190
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:45 pm
CID
-
CLT
1 stop13h 25m
Multiple Airlines
Thu 4/309:54 pm
CLT
-
CID
1 stop21h 01m
Multiple Airlines
Deal found 3/19$194
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:41 pm
CID
-
CLT
1 stop12h 40m
Multiple Airlines
Thu 4/95:07 pm
CLT
-
CID
1 stop25h 48m
Multiple Airlines
Deal found 3/19$199
This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:45 pm
CID
-
MYR
1 stop21h 48m
Multiple Airlines
Fri 4/1711:52 am
MYR
-
CID
1 stop7h 03m
Multiple Airlines
Deal found 3/20$204
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:45 pm
CID
-
CLT
1 stop13h 25m
Multiple Airlines
Thu 4/309:54 pm
CLT
-
CID
1 stop21h 01m
Multiple Airlines
Deal found 3/19$204
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:45 pm
CID
-
CLT
1 stop16h 20m
Multiple Airlines
Thu 5/79:54 pm
CLT
-
CID
1 stop21h 01m
Multiple Airlines
Deal found 3/19$211
This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:45 pm
CID
-
CLT
1 stop26h 13m
Multiple Airlines
Mon 4/208:56 am
CLT
-
CID
1 stop9h 59m
Multiple Airlines
Deal found 3/20$212
This CheapOair deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
-
CLT
1 stop25h 52m
Frontier
Tue 5/55:20 pm
CLT
-
DSM
1 stop21h 11m
Frontier
Deal found 3/18$212
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:45 pm
CID
-
CLT
2 stops26h 18m
Multiple Airlines
Thu 4/239:54 pm
CLT
-
CID
1 stop21h 01m
Multiple Airlines
Deal found 3/17$219
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:45 pm
CID
-
CLT
1 stop13h 25m
Multiple Airlines
Fri 5/86:28 am
CLT
-
CID
1 stop12h 27m
Multiple Airlines
Deal found 3/17$221
This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/57:00 am
DSM
-
MYR
1 stop12h 48m
Multiple Airlines
Wed 4/83:29 pm
MYR
-
DSM
1 stop23h 17m
Multiple Airlines
Deal found 3/20$229
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:45 pm
CID
-
CLT
1 stop26h 13m
Multiple Airlines
Sun 5/312:50 pm
CLT
-
CID
1 stop30h 05m
Multiple Airlines
Deal found 3/19$229

Find flight deals from Iowa to South Carolina

Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated March 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$190
(Kiwi.com)

One-way from

$82
(CheapOair)

Popular in

November

Cheapest in

January

Average price

$400
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
Search Deals
From Iowa to South Carolina
Search Deals
One-way flight from Iowa to South Carolina
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($42 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

OmahaMyrtle Beach

OMA - MYR

OMAMYR

Omaha Eppley Airfield

Tue 4/7

6:00 am-2:17 pm

1 stop7h 17m

Myrtle Beach Intl

Wed 4/15

11:00 am-3:39 pm

1 stop5h 39m

$305

OmahaMyrtle Beach

OMA - MYR

OMAMYR

Omaha Eppley Airfield

Sat 4/25

6:00 am-2:17 pm

1 stop7h 17m

Myrtle Beach Intl

Wed 4/29

3:15 pm-10:11 pm

1 stop7h 56m

$321

OmahaMyrtle Beach

OMA - MYR

OMAMYR

Omaha Eppley Airfield

Sat 5/9

8:01 am-2:18 pm

1 stop5h 17m

Myrtle Beach Intl

Tue 5/12

3:14 pm-9:38 pm

1 stop7h 24m

$321

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Sat 8/22

5:45 am-11:20 am

1 stop4h 35m

Savannah/Hilton Head

Sat 8/29

5:35 pm-9:50 pm

1 stop5h 15m

$323

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

Tue 6/2

6:25 am-2:12 pm

1 stop6h 47m

Myrtle Beach Intl

Wed 6/10

3:08 pm-9:31 pm

1 stop7h 23m

$323

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Sat 5/23

12:33 pm-9:25 pm

1 stop7h 52m

Savannah/Hilton Head

Wed 5/27

3:14 pm-9:31 pm

1 stop7h 17m

$323

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Mon 5/4

1:14 pm-10:31 pm

1 stop8h 17m

Savannah/Hilton Head

Sat 5/9

4:11 pm-11:58 pm

1 stop8h 47m

$326

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Tue 4/28

5:42 am-1:08 pm

1 stop6h 26m

Savannah/Hilton Head

Mon 5/4

6:49 pm-11:12 pm

1 stop5h 23m

$326

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Mon 4/27

8:00 am-2:40 pm

1 stop5h 40m

Savannah/Hilton Head

Tue 5/5

4:55 pm-9:38 pm

1 stop5h 43m

$326

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Tue 5/5

6:00 am-3:18 pm

2 stops8h 18m

Savannah/Hilton Head

Sat 5/9

5:40 am-12:18 pm

1 stop7h 38m

$328

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/22

Showing 1-10 of 60 resultsSorted by cheapest first
1
2
3
...
6

Best time to book a flight from Iowa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to South Carolina

What is the cheapest month to book a flight from Iowa to South Carolina?

Currently, May is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $166). Flying from Iowa to South Carolina in March is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to SC?

Find hourly flight availability from Iowa to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 22, 2026.

One of the essential ways to save on airfare from Iowa to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 34% on airfare.

What is the cheapest day to fly from Iowa to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Iowa to South Carolina. Price data was last updated on March 30, 2025.

Travelers seeking maximum savings on their Iowa to South Carolina flight should consider departing on Monday afternoons when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 22, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,324 reviews

Food

7.0

Boarding

8.1

Overall

8.0

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,324 reviews
Southwest
8.0
Very good
4,324 reviews

Food

7.0

Boarding

8.1

Overall

8.0

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Delta
7.9
Good
8,314 reviews
Southwest
8.0
Very good
4,324 reviews

Food

7.0

Boarding

8.1

Overall

8.0

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
United Airlines
7.4
Good
9,455 reviews
Southwest
8.0
Very good
4,324 reviews

Food

7.0

Boarding

8.1

Overall

8.0

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,489 reviews
Southwest
8.0
Very good
4,324 reviews

Food

7.0

Boarding

8.1

Overall

8.0

Crew

8.6

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to South Carolina?

    Airlines like United Airlines, Delta, and American Airlines fly from Iowa to South Carolina in about 4h 35m. The time it takes to get you to your destination can typically vary by up to 3h 42m. The distance between Iowa and South Carolina is about 887 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Iowa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Iowa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to South Carolina.

  • Can I find deals for business class flights from Iowa to South Carolina?

    Yes. Cheapflights offers flight deals from Iowa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $166). Flying from Iowa to South Carolina in March is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Iowa to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
San Francisco to Newark flights
Los Angeles to Honolulu flights
San Francisco to John F Kennedy Intl flights
John F Kennedy Intl to San Francisco flights
Newark to San Francisco flights
LaGuardia to Fort Lauderdale flights
Newark to Miami flights
LaGuardia to Miami flights
John F Kennedy Intl to Miami flights
John F Kennedy Intl to Fort Lauderdale flights
Newark to Fort Lauderdale flights
Newark to West Palm Beach flights
John F Kennedy Intl to Los Angeles flights
John F Kennedy Intl to Orlando flights
John F Kennedy Intl to Las Vegas flights
San Francisco to LaGuardia flights
LaGuardia to San Francisco flights
LaGuardia to Dallas/Fort Worth flights
Dallas/Fort Worth to Las Vegas flights
Dallas/Fort Worth to LaGuardia flights
Newark to Los Angeles flights
Newark to Orlando flights
Los Angeles to John F Kennedy Intl flights
Dallas/Fort Worth to Seattle flights
Long Beach to Honolulu flights
Seattle to Las Vegas flights
Newark to Dallas/Fort Worth flights
Seattle to Los Angeles flights
Ontario to Honolulu flights
John F Kennedy Intl to West Palm Beach flights
John F Kennedy Intl to Dallas/Fort Worth flights
Los Angeles to Newark flights
Los Angeles to Seattle flights
LaGuardia to Orlando flights
San Francisco to Las Vegas flights
Burbank to Honolulu flights
Dulles Intl to Dallas/Fort Worth flights
Dallas/Fort Worth to Newark flights
Newark to Las Vegas flights
John F Kennedy Intl to O'Hare Intl flights
Dallas/Fort Worth to John F Kennedy Intl flights
Seattle to Dallas/Fort Worth flights
O'Hare Intl to John F Kennedy Intl flights
O'Hare Intl to Las Vegas flights
O'Hare Intl to Orlando flights
Dulles Intl to Las Vegas flights
Los Angeles to Dallas/Fort Worth flights
LaGuardia to Los Angeles flights
Dallas/Fort Worth to Los Angeles flights
Dallas/Fort Worth to Orlando flights

Top 4 airlines flying from Iowa to South Carolina

Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$148Average$377FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$227Average$403FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$228Average$416FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$272Average$404FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.