HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$89+ Cheap flights from Iowa to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Aug 25 — Sep 11
Mon 8/25
Mon 9/1
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Iowa to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Iowa to South Carolina

Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated August 20, 2025.

Round-trip from

$181
(FlightHub)

One-way from

$89
(FlightHub)

Popular in

June

Cheapest in

August

Average price

$302
From Iowa to South Carolina
Search Deals
One-way flight from Iowa to South Carolina
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($32 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
Search Deals

Find flight deals from Iowa to South Carolina

Cheapest flights from Iowa to South Carolina
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2025.

This FlightHub deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/47:48 pmOMA - CLT
1 stop19h 37mFrontier
Sun 9/75:20 pmCLT - OMA
1 stop21h 01mFrontier
Deal found 8/19$181
This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/252:25 pmDSM - CLT
1 stop25h 18mFrontier
Sun 9/285:20 pmCLT - DSM
1 stop21h 20mFrontier
Deal found 8/18$181
This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/232:37 pmDSM - CLT
1 stop25h 02mFrontier
Sun 10/265:34 pmCLT - DSM
1 stop21h 18mFrontier
Deal found 8/18$204
This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/257:48 pmOMA - CLT
1 stop19h 55mFrontier
Sun 9/285:20 pmCLT - OMA
1 stop21h 01mFrontier
Deal found 8/18$205
This FlightHub deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/114:26 pmOMA - CLT
1 stop14h 34mFrontier
Thu 10/165:34 pmCLT - OMA
1 stop27h 30mFrontier
Deal found 8/19$215
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/138:30 amDSM - CLT
1 stop28h 05mMultiple Airlines
Thu 10/1610:06 pmCLT - DSM
1 stop11h 24mMultiple Airlines
Deal found 8/19$223
This FlightHub deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/97:46 pmOMA - CLT
1 stop20h 31mFrontier
Sun 11/166:07 pmCLT - OMA
1 stop26h 59mFrontier
Deal found 8/19$225
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/298:25 amDSM - CLT
1 stop29h 04mMultiple Airlines
Fri 10/39:10 amCLT - DSM
1 stop6h 40mMultiple Airlines
Deal found 8/18$236
This FlightHub deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/22:25 pmDSM - CLT
1 stop25h 18mFrontier
Sun 10/55:20 pmCLT - DSM
1 stop21h 20mFrontier
Deal found 8/18$238
This Frontier deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/58:16 pmCID - CLT
2 stops15h 45mFrontier
Sun 9/710:43 pmCLT - CID
2 stops21h 48mFrontier
Deal found 8/17$240
This Mytrip deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/210:41 amDSM - CLT
1 stop11h 18mMultiple Airlines
Thu 10/96:15 amCLT - DSM
2 stops14h 42mMultiple Airlines
Deal found 8/18$243
This FlightHub deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/28:16 pmCID - CLT
1 stop19h 27mFrontier
Sun 10/55:20 pmCLT - CID
1 stop27h 11mFrontier
Deal found 8/19$245

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.

Fly from

Iowa

Fly to

South Carolina

Route

Depart

Return

Price

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Thu 9/25

2:25 pm-4:43 pm

1 stop25h 18m

Charlotte Douglas

Thu 10/2

5:20 pm-1:40 pm

1 stop21h 20m

$181

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Thu 9/25

2:25 pm-4:43 pm

1 stop25h 18m

Charlotte Douglas

Sun 9/28

5:20 pm-1:40 pm

1 stop21h 20m

$181

OmahaCharlotte

OMA - CLT

OMACLT

Omaha Eppley Airfield

Sun 11/9

7:46 pm-5:17 pm

1 stop20h 31m

Charlotte Douglas

Sun 11/16

6:07 pm-8:06 pm

1 stop26h 59m

$181

OmahaCharlotte

OMA - CLT

OMACLT

Omaha Eppley Airfield

Thu 9/4

7:48 pm-4:25 pm

1 stop19h 37m

Charlotte Douglas

Sun 9/7

5:20 pm-1:21 pm

1 stop21h 01m

$181

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Thu 10/23

2:37 pm-4:39 pm

1 stop25h 02m

Charlotte Douglas

Sun 10/26

5:34 pm-1:52 pm

1 stop21h 18m

$204

OmahaCharlotte

OMA - CLT

OMACLT

Omaha Eppley Airfield

Sat 10/11

4:26 pm-8:00 am

1 stop14h 34m

Charlotte Douglas

Wed 10/15

4:00 pm-10:28 am

1 stop19h 28m

$205

OmahaCharlotte

OMA - CLT

OMACLT

Omaha Eppley Airfield

Thu 9/25

7:48 pm-4:43 pm

1 stop19h 55m

Charlotte Douglas

Sun 9/28

5:20 pm-1:21 pm

1 stop21h 01m

$205

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Mon 10/13

8:30 am-1:35 pm

1 stop28h 05m

Charlotte Douglas

Thu 10/16

10:06 pm-8:30 am

1 stop11h 24m

$223

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Mon 9/29

8:25 am-2:29 pm

1 stop29h 04m

Charlotte Douglas

Fri 10/3

9:10 am-2:50 pm

1 stop6h 40m

$236

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Thu 10/2

10:41 am-10:59 pm

1 stop11h 18m

Charlotte Douglas

Thu 10/9

6:15 am-7:57 pm

2 stops14h 42m

$243

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/17

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Iowa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to South Carolina

What is the cheapest month to book a flight from Iowa to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $217). Flying from Iowa to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to SC?

Find hourly flight availability from Iowa to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 20, 2025.

When flying from Iowa to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 20, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Food

7.0

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,246 reviews
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Food

7.0

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
8.0
Very good
7,982 reviews
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Food

7.0

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,928 reviews
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Food

7.0

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Food

7.0

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to South Carolina?

    Airlines like Frontier, American Airlines, and Delta fly from Iowa to South Carolina in about 4h 34m. The time it takes to get you to your destination can typically vary by up to 20h 44m. The distance between Iowa and South Carolina is about 890 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Iowa to South Carolina one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $89. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from Iowa to South Carolina for a low price.

  • Can I find deals for flights from Iowa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Iowa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to South Carolina.

  • Can I find deals for business class flights from Iowa to South Carolina?

    Yes. Cheapflights offers flight deals from Iowa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $217). Flying from Iowa to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Iowa to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to John F Kennedy Intl flights
John F Kennedy Intl to Los Angeles flights
Dallas/Fort Worth to John F Kennedy Intl flights
Dallas/Fort Worth to LaGuardia flights
Dallas/Fort Worth to Seattle flights
Los Angeles to Newark flights
John F Kennedy Intl to Orlando flights
Dallas/Fort Worth to Las Vegas flights
John F Kennedy Intl to Las Vegas flights
Newark to Fort Lauderdale flights
Newark to Los Angeles flights
Dallas/Fort Worth to O'Hare Intl flights
San Francisco to John F Kennedy Intl flights
John F Kennedy Intl to Miami flights
Los Angeles to Seattle flights
Newark to Miami flights
John F Kennedy Intl to Dallas/Fort Worth flights
John F Kennedy Intl to O'Hare Intl flights
LaGuardia to Miami flights
LaGuardia to Fort Lauderdale flights
Fort Lauderdale to Newark flights
Ontario to Seattle flights
LaGuardia to Dallas/Fort Worth flights
John F Kennedy Intl to San Francisco flights
San Francisco to Newark flights
Seattle to Los Angeles flights
Los Angeles to Dallas/Fort Worth flights
Dallas/Fort Worth to Denver flights
Seattle to Las Vegas flights
O'Hare Intl to LaGuardia flights
O'Hare Intl to Dallas/Fort Worth flights
LaGuardia to O'Hare Intl flights
Newark to O'Hare Intl flights
Dallas/Fort Worth to Los Angeles flights
John F Kennedy Intl to Fort Lauderdale flights
Newark to Orlando flights
Miami to LaGuardia flights
Newark to Las Vegas flights
Dallas/Fort Worth to Newark flights
Los Angeles to LaGuardia flights
Los Angeles to O'Hare Intl flights
Atlanta to LaGuardia flights
Atlanta to John F Kennedy Intl flights
O'Hare Intl to John F Kennedy Intl flights
O'Hare Intl to Las Vegas flights
Fort Lauderdale to LaGuardia flights
Newark to San Francisco flights
John F Kennedy Intl to Atlanta flights
Newark to Dallas/Fort Worth flights
O'Hare Intl to Newark flights

Top 4 airlines flying from Iowa to South Carolina

Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$228Average$397FlexibilityNo cancel feeOn-time71%
DeltaCheapest$232Average$366FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$235Average$453FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$272Average$404FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.