$119+ Cheap flights from Iowa to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Jun 27 — Jul 41
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to South Carolina with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to South Carolina
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Cheapest flights from Iowa to South CarolinaExplore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 28, 2026.
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 28, 2026.
This Booking.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/238:25 pm
OMA
- CLT
1 stop24h 00m
Frontier
Tue 6/307:14 pm
CLT
- OMA
1 stop25h 16m
Frontier
Deal found 5/25![Frontier logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:55 pm
CID
- CLT
1 stop26h 12m
Multiple Airlines
Sun 7/196:41 pm
CLT
- CID
1 stop23h 24m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$245
This Mytrip deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/188:15 pm
OMA
- CLT
1 stop24h 10m
Frontier
Tue 6/237:14 pm
CLT
- OMA
1 stop25h 16m
Frontier
Deal found 5/27![Frontier logo]()
$259
This CheapOair deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/192:16 pm
DSM
- CLT
1 stop27h 03m
Frontier
Sun 8/237:14 pm
CLT
- DSM
1 stop19h 17m
Frontier
Deal found 5/26![Frontier logo]()
$260
This Mytrip deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/198:15 pm
OMA
- CLT
1 stop24h 10m
Frontier
Tue 6/237:14 pm
CLT
- OMA
1 stop25h 16m
Frontier
Deal found 5/27![Frontier logo]()
$260
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/812:40 pm
CID
- MYR
1 stop4h 57m
American Airlines
Tue 7/144:43 pm
MYR
- CID
1 stop6h 20m
American Airlines
Deal found 5/27![American Airlines logo]()
$261
This Booking.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/158:15 pm
OMA
- CLT
1 stop21h 04m
Frontier
Tue 6/307:14 pm
CLT
- OMA
1 stop25h 16m
Frontier
Deal found 5/24![Frontier logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:55 pm
CID
- CLT
1 stop26h 12m
Multiple Airlines
Sun 7/196:41 pm
CLT
- CID
1 stop23h 24m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$264
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/239:23 am
DSM
- CLT
1 stop10h 27m
American Airlines
Tue 6/2310:45 pm
CLT
- DSM
Nonstop2h 27m
American Airlines
Deal found 5/24![American Airlines logo]()
$267
This Booking.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:19 pm
OMA
- CLT
1 stop24h 05m
Frontier
Mon 8/2410:14 pm
CLT
- OMA
1 stop22h 20m
Frontier
Deal found 5/25![Frontier logo]()
$270
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:10 am
DSM
- CLT
1 stop4h 45m
Southwest
Wed 6/101:25 pm
CLT
- DSM
2 stops10h 20m
Southwest
Deal found 5/26![Southwest logo]()
$274
This Booking.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:01 pm
CID
- CLT
1 stop29h 18m
Frontier
Mon 8/1010:04 pm
CLT
- CID
1 stop17h 02m
Frontier
Deal found 5/25![Frontier logo]()
$275
Best flights from Iowa to South CarolinaDiscover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 28, 2026.
Discover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 28, 2026.
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:00 am
CID
- MYR
1 stop6h 33m
Delta
Tue 8/2511:33 am
MYR
- CID
2 stops11h 39m
Delta
Deal found 5/25![Delta logo]()
$266
This American Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:42 pm
CID
- MYR
1 stop3h 45m
American Airlines
Wed 10/218:41 pm
MYR
- CID
1 stop4h 29m
American Airlines
Deal found 5/28![American Airlines logo]()
$304
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:10 am
DSM
- CLT
1 stop4h 45m
Southwest
Tue 7/147:05 pm
CLT
- DSM
1 stop4h 45m
Southwest
Deal found 5/27![Southwest logo]()
$325
This United Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:25 am
CID
- CHS
2 stops7h 02m
United Airlines
Sat 6/62:47 pm
CHS
- CID
2 stops9h 04m
United Airlines
Deal found 5/25![United Airlines logo]()
$409
This Delta deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1411:00 am
CID
- MYR
2 stops11h 35m
Delta
Wed 10/2111:10 am
MYR
- CID
2 stops11h 41m
Delta
Deal found 5/24![Delta logo]()
$271
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:17 am
CID
- CHS
1 stop7h 24m
American Airlines
Tue 8/117:00 am
CHS
- CID
1 stop7h 12m
American Airlines
Deal found 5/24![American Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/125:50 am
CID
- MYR
1 stop6h 10m
Delta
Sat 7/185:30 pm
MYR
- CID
1 stop6h 20m
Delta
Deal found 5/26![Delta logo]()
$285
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/185:10 am
DSM
- CLT
1 stop4h 45m
Southwest
Sat 7/257:50 am
CLT
- DSM
1 stop4h 45m
Southwest
Deal found 5/26![Southwest logo]()
$335
This American Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:00 am
MLI
- CLT
Nonstop2h 21m
American Airlines
Wed 8/57:50 pm
CLT
- MLI
Nonstop2h 23m
American Airlines
Deal found 5/23![American Airlines logo]()
$333
This Southwest deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:30 am
DSM
- CLT
2 stops7h 55m
Southwest
Sun 9/69:10 am
CLT
- DSM
1 stop4h 10m
Southwest
Deal found 5/24![Southwest logo]()
$340
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/55:45 am
CID
- CHS
1 stop6h 56m
Delta
Sun 7/126:28 pm
CHS
- CID
1 stop4h 35m
Delta
Deal found 5/27![Delta logo]()
$323
This United Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:00 am
OMA
- MYR
1 stop7h 33m
United Airlines
Wed 10/283:20 pm
MYR
- OMA
1 stop7h 09m
United Airlines
Deal found 5/27![United Airlines logo]()
$415
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:00 am
DSM
- CLT
2 stops9h 50m
Southwest
Mon 9/2111:50 am
CLT
- DSM
2 stops10h 25m
Southwest
Deal found 5/26![Southwest logo]()
$345
This Delta deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:00 am
CID
- CHS
1 stop6h 11m
Delta
Mon 8/245:10 am
CHS
- CID
2 stops7h 10m
Delta
Deal found 5/24![Delta logo]()
$328
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/21:41 pm
DSM
- MYR
1 stop7h 02m
American Airlines
Wed 7/86:51 am
MYR
- DSM
1 stop7h 05m
American Airlines
Deal found 5/27![American Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:20 am
DSM
- CLT
2 stops8h 15m
Southwest
Wed 7/11:25 pm
CLT
- DSM
2 stops10h 20m
Southwest
Deal found 5/25![Southwest logo]()
$345
This United Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/93:13 pm
OMA
- SAV
1 stop5h 43m
United Airlines
Mon 7/134:15 pm
SAV
- OMA
1 stop8h 27m
United Airlines
Deal found 5/24![United Airlines logo]()
$427
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/105:04 am
CID
- MYR
1 stop5h 30m
American Airlines
Sat 8/155:00 am
MYR
- CID
2 stops9h 12m
American Airlines
Deal found 5/27![American Airlines logo]()
$375
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/304:19 pm
CID
- CHS
2 stops7h 07m
Delta
Thu 8/66:45 pm
CHS
- CID
1 stop4h 27m
Delta
Deal found 5/27![Delta logo]()
$343
This United Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:00 am
DSM
- MYR
1 stop7h 19m
United Airlines
Wed 7/293:15 pm
MYR
- DSM
1 stop7h 07m
United Airlines
Deal found 5/23![United Airlines logo]()
$431
This Southwest deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/233:50 pm
OMA
- CLT
1 stop4h 20m
Southwest
Tue 6/301:25 pm
CLT
- OMA
2 stops6h 50m
Southwest
Deal found 5/24![Southwest logo]()
$368
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:00 am
CID
- CHS
2 stops7h 41m
American Airlines
Tue 6/165:00 am
CHS
- CID
2 stops7h 05m
American Airlines
Deal found 5/25![American Airlines logo]()
$380
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/125:50 am
CID
- CHS
1 stop5h 10m
Delta
Sat 7/186:24 pm
CHS
- CID
1 stop4h 39m
Delta
Deal found 5/26![Delta logo]()
$351
This United Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/113:47 pm
MLI
- CLT
1 stop4h 42m
United Airlines
Wed 7/158:05 am
CLT
- MLI
1 stop6h 51m
United Airlines
Deal found 5/27![United Airlines logo]()
$433
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/154:40 pm
DSM
- CLT
2 stops5h 35m
Southwest
Sat 6/201:05 pm
CLT
- DSM
2 stops10h 45m
Southwest
Deal found 5/27![Southwest logo]()
$373
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/115:10 pm
MLI
- CLT
1 stop5h 48m
Delta
Tue 7/145:30 am
CLT
- MLI
1 stop5h 42m
Delta
Deal found 5/28![Delta logo]()
$353
This United Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/111:15 pm
MLI
- CLT
2 stops9h 44m
United Airlines
Tue 7/1410:35 am
CLT
- MLI
1 stop4h 21m
United Airlines
Deal found 5/25![United Airlines logo]()
$438
This American Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:10 am
DSM
- CLT
1 stop6h 12m
American Airlines
Wed 8/192:41 pm
CLT
- DSM
1 stop5h 22m
American Airlines
Deal found 5/23![American Airlines logo]()
$411
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:30 am
OMA
- MYR
1 stop6h 10m
Southwest
Sun 9/206:50 pm
MYR
- OMA
1 stop5h 05m
Southwest
Deal found 5/26![Southwest logo]()
$376
This Delta deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:30 am
MLI
- CLT
1 stop6h 05m
Delta
Wed 8/55:30 am
CLT
- MLI
1 stop5h 55m
Delta
Deal found 5/23![Delta logo]()
$353
Last-minute flights from Iowa to South CarolinaDiscover last-minute flight deals from Iowa to South Carolina. Data last updated May 28, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to South Carolina. Data last updated May 28, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:10 am
DSM
- CLT
1 stop4h 45m
Southwest
Wed 6/101:25 pm
CLT
- DSM
2 stops10h 20m
Southwest
Deal found 5/26![Southwest logo]()
$274
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/64:24 pm
MLI
- CLT
Nonstop2h 21m
American Airlines
Sat 6/610:43 pm
CLT
- MLI
1 stop12h 58m
American Airlines
Deal found 5/24![American Airlines logo]()
$294
This Booking.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/98:25 pm
OMA
- CLT
1 stop24h 00m
Frontier
Fri 6/1210:14 pm
CLT
- OMA
1 stop22h 16m
Frontier
Deal found 5/26![Frontier logo]()
$302
This Booking.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/108:15 pm
OMA
- CLT
1 stop21h 04m
Frontier
Fri 8/2810:14 pm
CLT
- OMA
1 stop22h 20m
Frontier
Deal found 5/24![Frontier logo]()
$282
This Booking.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/118:15 pm
OMA
- CLT
1 stop24h 10m
Frontier
Mon 6/1510:14 pm
CLT
- OMA
1 stop22h 16m
Frontier
Deal found 5/25![Frontier logo]()
$301
This Booking.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/158:15 pm
OMA
- CLT
1 stop21h 04m
Frontier
Tue 6/307:14 pm
CLT
- OMA
1 stop25h 16m
Frontier
Deal found 5/24![Frontier logo]()
$261
This Booking.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/168:25 pm
OMA
- CLT
1 stop24h 00m
Frontier
Sat 6/2010:14 pm
CLT
- OMA
1 stop22h 16m
Frontier
Deal found 5/27![Frontier logo]()
$280
This Mytrip deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/188:15 pm
OMA
- CLT
1 stop24h 10m
Frontier
Tue 6/237:14 pm
CLT
- OMA
1 stop25h 16m
Frontier
Deal found 5/27![Frontier logo]()
$259
This Mytrip deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/198:15 pm
OMA
- CLT
1 stop24h 10m
Frontier
Tue 6/237:14 pm
CLT
- OMA
1 stop25h 16m
Frontier
Deal found 5/27![Frontier logo]()
$260
This Booking.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/238:25 pm
OMA
- CLT
1 stop24h 00m
Frontier
Tue 6/307:14 pm
CLT
- OMA
1 stop25h 16m
Frontier
Deal found 5/25![Frontier logo]()
$242
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/239:23 am
DSM
- CLT
1 stop10h 27m
American Airlines
Tue 6/2310:45 pm
CLT
- DSM
Nonstop2h 27m
American Airlines
Deal found 5/24![American Airlines logo]()
$267
This Booking.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/258:15 pm
OMA
- CLT
1 stop24h 10m
Frontier
Thu 7/27:14 pm
CLT
- OMA
1 stop25h 16m
Frontier
Deal found 5/26![Frontier logo]()
$281
One-way flights from Iowa to South CarolinaSearch for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated May 28, 2026.
Search for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated May 28, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/274:40 pm
DSM
- CLT
1 stop27h 27m
Multiple Airlines
Deal found 5/28![Multiple Airlines logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/205:55 pm
CID
- CLT
1 stop26h 12m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$121
This Booking.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/168:25 pm
OMA
- CLT
1 stop24h 00m
Frontier
Deal found 5/25![Frontier logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/104:40 pm
DSM
- CLT
1 stop27h 27m
Multiple Airlines
Deal found 5/25![Multiple Airlines logo]()
$133
This Trip.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/213:01 pm
CID
- CLT
1 stop29h 18m
Frontier
Deal found 5/25![Frontier logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/204:40 pm
DSM
- CLT
1 stop27h 27m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$140
This Trip.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/98:25 pm
OMA
- CLT
1 stop24h 00m
Frontier
Deal found 5/26![Frontier logo]()
$145
This Booking.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/98:05 pm
OMA
- CLT
1 stop24h 14m
Frontier
Deal found 5/24![Frontier logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/511:48 am
DSM
- MYR
1 stop26h 26m
Multiple Airlines
Deal found 5/25![Multiple Airlines logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/235:08 pm
DSM
- CLT
2 stops26h 59m
Multiple Airlines
Deal found 5/24![Multiple Airlines logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/174:40 pm
DSM
- CLT
1 stop27h 27m
Multiple Airlines
Deal found 5/24![Multiple Airlines logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/193:59 pm
DSM
- CLT
2 stops28h 08m
Multiple Airlines
Deal found 5/24![Multiple Airlines logo]()
$159
Find flight deals from Iowa to South Carolina
Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated May 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $242 (Booking.com) |
One-way from | $119 (Kiwi.com) |
Popular in | June |
Cheapest in | January |
Average price | $442 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 28, 2026.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Tue 8/11
6:00 am-1:33 pm
1 stop6h 33m
Myrtle Beach Intl
Tue 8/25
11:33 am-10:12 pm
2 stops11h 39m
$266
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Wed 10/14
11:00 am-11:35 pm
2 stops11h 35m
Myrtle Beach Intl
Wed 10/21
11:10 am-9:51 pm
2 stops11h 41m
$271
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Sun 7/12
5:50 am-1:00 pm
1 stop6h 10m
Myrtle Beach Intl
Sat 7/18
5:30 pm-10:50 pm
1 stop6h 20m
$285
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Wed 10/14
6:42 pm-11:27 pm
1 stop3h 45m
Myrtle Beach Intl
Wed 10/21
8:41 pm-12:10 am
1 stop4h 29m
$304
Cedar RapidsCharleston
CID - CHS
CIDCHS
Cedar Rapids
Tue 8/4
6:17 am-2:41 pm
1 stop7h 24m
Charleston
Tue 8/11
7:00 am-1:12 pm
1 stop7h 12m
$309
Cedar RapidsCharleston
CID - CHS
CIDCHS
Cedar Rapids
Sun 7/5
5:45 am-1:41 pm
1 stop6h 56m
Charleston
Sun 7/12
6:28 pm-10:03 pm
1 stop4h 35m
$323
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
Mon 7/13
5:10 am-10:55 am
1 stop4h 45m
Charlotte Douglas
Tue 7/14
7:05 pm-10:50 pm
1 stop4h 45m
$325
Cedar RapidsCharleston
CID - CHS
CIDCHS
Cedar Rapids
Thu 8/20
6:00 am-1:11 pm
1 stop6h 11m
Charleston
Mon 8/24
5:10 am-11:20 am
2 stops7h 10m
$328
Quickest round-trip
MolineCharlotte
MLI - CLT
MLICLT
Moline Quad-City
Sat 7/4
6:00 am-9:21 am
Nonstop2h 21m
Charlotte Douglas
Wed 8/5
7:50 pm-9:13 pm
Nonstop2h 23m
$333
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
Sat 7/18
5:10 am-10:55 am
1 stop4h 45m
Charlotte Douglas
Sat 7/25
7:50 am-11:35 am
1 stop4h 45m
$335
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
DSM-MYR
DSM-CLT
OMA-CLT
CID-MYR
OMA-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to South Carolina
USIA-USSC
DSM-MYR
DSM-CLT
OMA-CLT
CID-MYR
What is the cheapest month to book a flight from Iowa to South Carolina?
Currently, November is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $118). Flying from Iowa to South Carolina in March is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Iowa to South Carolina?
How far ahead should I book a flight from Iowa to South Carolina?
The best time to book flights from Iowa to South Carolina is 21 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated May 28, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Comfort
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Comfort
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Comfort
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Comfort
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Comfort
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Iowa to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to South Carolina by cabin class
Find flights from Iowa to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and South Carolina flights
Browse other Iowa and South Carolina flight options. Last updated on May 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Iowa after your stay in South Carolina
Iowa to South Carolina flights
Consider these flights traveling from Iowa to South Carolina.
Top 4 airlines flying from Iowa to South Carolina
Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$237 | Average$408 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$237 | Average$408 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$432 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$272 | Average$406 | FlexibilityNo cancel fee | On-time63% |