$130+ Cheap flights from Iowa to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Oct 29 — Nov 51
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to South Carolina
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Cheapest flights from Iowa to South CarolinaExplore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2026.
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2026.
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:02 am -
1 stop4h 19m
Sat 11/71:56 pm -
1 stop4h 34m
Deal found 9/28![United Airlines logo]()
$291
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:01 pm -
1 stop6h 28m
Sat 11/145:03 pm -
1 stop4h 59m
Deal found 9/25![American Airlines logo]()
$291
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:15 am -
1 stop4h 52m
Mon 11/237:19 pm -
1 stop4h 50m
Deal found 9/26![Delta logo]()
$315
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:26 am -
1 stop4h 06m
Sun 11/228:44 pm -
1 stop4h 14m
Deal found 9/27![American Airlines logo]()
$315
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:26 pm -
1 stop6h 43m
Sat 10/317:17 am -
1 stop7h 13m
Deal found 9/27![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/173:11 pm -
1 stop4h 47m
Tue 10/205:46 pm -
1 stop4h 37m
Deal found 9/25![United Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am -
1 stop5h 56m
Wed 11/115:03 pm -
1 stop7h 23m
Deal found 9/28![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1711:27 am -
1 stop5h 35m
Tue 10/203:03 pm -
2 stops9h 32m
Deal found 9/26![United Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:13 pm -
1 stop4h 46m
Thu 10/296:00 am -
1 stop8h 07m
Deal found 9/28![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:15 am -
1 stop4h 52m
Mon 11/237:19 pm -
1 stop4h 50m
Deal found 9/26![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:25 am -
1 stop3h 55m
Sun 11/228:44 pm -
1 stop4h 14m
Deal found 9/27![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:15 am -
1 stop4h 53m
Tue 12/16:02 pm -
1 stop6h 08m
Deal found 9/23![Delta logo]()
$339
Best flights from Iowa to South CarolinaDiscover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 29, 2026.
Discover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 29, 2026.
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:02 am -
1 stop4h 19m
Sat 11/71:56 pm -
1 stop4h 34m
Deal found 9/28![United Airlines logo]()
$291
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/115:15 pm -
1 stop4h 10m
Fri 1/156:00 am -
1 stop5h 18m
Deal found 9/24![Delta logo]()
$334
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:13 pm -
1 stop4h 46m
Tue 10/207:16 am -
1 stop7h 06m
Deal found 9/23![American Airlines logo]()
$354
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
2 stops10h 25m
Sat 11/149:45 am -
2 stops11h 00m
Deal found 9/26![Southwest logo]()
$371
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/147:00 pm -
1 stop4h 35m
Sat 2/2010:20 am -
2 stops11h 21m
Deal found 9/27![United Airlines logo]()
$332
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:15 am -
1 stop4h 53m
Tue 12/16:02 pm -
1 stop6h 08m
Deal found 9/23![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/311:38 am -
1 stop7h 16m
Sun 12/65:08 am -
1 stop6h 50m
Deal found 9/28![American Airlines logo]()
$371
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:15 am -
1 stop4h 53m
Wed 12/26:02 pm -
1 stop6h 08m
Deal found 9/23![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:00 am -
2 stops7h 17m
Wed 12/210:28 am -
1 stop6h 23m
Deal found 9/23![United Airlines logo]()
$344
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:20 am -
1 stop12h 45m
Mon 11/25:30 am -
2 stops8h 40m
Deal found 9/27![Southwest logo]()
$397
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:30 am -
1 stop6h 34m
Tue 10/203:00 pm -
2 stops8h 47m
Deal found 9/23![United Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:15 am -
1 stop4h 52m
Mon 11/237:19 pm -
1 stop4h 50m
Deal found 9/26![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:00 am -
2 stops9h 25m
Mon 12/76:35 am -
2 stops8h 40m
Deal found 9/26![Southwest logo]()
$406
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:00 am -
1 stop5h 56m
Sat 12/199:05 am -
2 stops11h 04m
Deal found 9/24![American Airlines logo]()
$426
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:00 am -
2 stops11h 30m
Mon 12/71:30 pm -
2 stops9h 30m
Deal found 9/26![Southwest logo]()
$406
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/105:15 pm -
1 stop5h 41m
Mon 1/186:30 am -
1 stop4h 48m
Deal found 9/27![Delta logo]()
$371
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3010:00 am -
1 stop5h 54m
Wed 2/36:30 am -
1 stop4h 38m
Deal found 9/25![United Airlines logo]()
$391
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/161:58 pm -
2 stops8h 01m
Sun 12/208:23 pm -
1 stop4h 35m
Deal found 9/24![American Airlines logo]()
$447
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:52 pm -
1 stop4h 07m
Sun 11/156:34 am -
1 stop5h 10m
Deal found 9/28![Delta logo]()
$371
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/265:10 am -
2 stops11h 50m
Mon 11/25:30 am -
2 stops8h 40m
Deal found 9/24![Southwest logo]()
$412
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/148:03 am -
2 stops8h 08m
Wed 11/1811:27 am -
2 stops11h 08m
Deal found 9/28![United Airlines logo]()
$401
This Southwest deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:35 am -
2 stops9h 40m
Wed 10/217:50 am -
1 stop4h 40m
Deal found 9/26![Southwest logo]()
$426
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/109:37 am -
2 stops8h 22m
Tue 1/192:30 pm -
2 stops8h 11m
Deal found 9/27![United Airlines logo]()
$404
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/611:28 am -
1 stop4h 42m
Fri 11/135:54 pm -
1 stop7h 03m
Deal found 9/27![American Airlines logo]()
$513
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:52 pm -
1 stop4h 01m
Sun 11/227:00 am -
1 stop4h 44m
Deal found 9/24![Delta logo]()
$427
This Southwest deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:10 pm -
2 stops13h 35m
Wed 10/212:10 pm -
2 stops8h 50m
Deal found 9/24![Southwest logo]()
$465
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/303:00 pm -
1 stop5h 54m
Wed 2/36:00 am -
1 stop7h 27m
Deal found 9/28![United Airlines logo]()
$425
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:13 pm -
1 stop4h 46m
Thu 10/228:08 pm -
1 stop4h 42m
Deal found 9/26![American Airlines logo]()
$516
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3011:28 am -
1 stop4h 26m
Wed 2/36:30 am -
1 stop6h 57m
Deal found 9/24![United Airlines logo]()
$425
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/195:00 pm -
1 stop24h 20m
Thu 12/311:56 pm -
1 stop6h 01m
Deal found 9/27![Delta logo]()
$493
Last-minute flights from Iowa to South CarolinaDiscover last-minute flight deals from Iowa to South Carolina. Data last updated September 29, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to South Carolina. Data last updated September 29, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/113:54 pm -
1 stop15h 09m
Wed 10/142:42 pm -
1 stop27h 10m
Deal found 9/28![Multiple Airlines logo]()
$353
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:13 pm -
1 stop4h 46m
Tue 10/207:16 am -
1 stop7h 06m
Deal found 9/23![American Airlines logo]()
$354
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:30 am -
1 stop6h 34m
Tue 10/203:00 pm -
2 stops8h 47m
Deal found 9/23![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/162:26 pm -
1 stop8h 12m
Thu 10/228:30 pm -
1 stop4h 28m
Deal found 9/26![American Airlines logo]()
$354
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/173:11 pm -
1 stop4h 47m
Tue 10/205:46 pm -
1 stop4h 37m
Deal found 9/25![United Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/174:12 pm -
1 stop5h 40m
Sat 10/314:57 pm -
1 stop7h 10m
Deal found 9/26![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1711:27 am -
1 stop5h 35m
Tue 10/203:03 pm -
2 stops9h 32m
Deal found 9/26![United Airlines logo]()
$330
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:50 am -
2 stops12h 45m
Tue 10/201:25 pm -
2 stops9h 35m
Deal found 9/25![Southwest logo]()
$341
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/199:26 am -
1 stop4h 36m
Mon 10/267:04 pm -
1 stop5h 54m
Deal found 9/28![American Airlines logo]()
$350
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:13 pm -
1 stop4h 46m
Thu 10/296:00 am -
1 stop8h 07m
Deal found 9/28![American Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:26 pm -
1 stop6h 43m
Sat 10/317:17 am -
1 stop7h 13m
Deal found 9/27![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:02 am -
1 stop4h 19m
Sat 11/71:56 pm -
1 stop4h 34m
Deal found 9/28![United Airlines logo]()
$291
One-way flights from Iowa to South CarolinaSearch for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 29, 2026.
Search for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:15 pm -
1 stop15h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Allegiant Air logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:15 pm -
2 stops26h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Multiple Airlines logo]()
$151
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/189:55 am -
1 stop7h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![United Airlines logo]()
$163
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:52 pm -
1 stop4h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Delta logo]()
$163
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/188:07 am -
1 stop7h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![American Airlines logo]()
$163
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:00 am -
2 stops9h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Southwest logo]()
$168
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:00 am -
2 stops10h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Southwest logo]()
$168
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:50 am -
2 stops12h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![Southwest logo]()
$174
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:00 am -
2 stops12h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Southwest logo]()
$174
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:58 pm -
1 stop7h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![American Airlines logo]()
$188
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:31 pm -
1 stop6h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![American Airlines logo]()
$191
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:25 am -
2 stops6h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Southwest logo]()
$196
Find flight deals from Iowa to South Carolina
Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated September 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $291 (American Airlines) |
One-way from | $130 (Kiwi.com) |
Popular in | March |
Cheapest in | April |
Average price | $450 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 29, 2026.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Thu 11/12
4:15 pm-8:51 am
1 stop15h 36m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$130
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Thu 11/12
4:15 pm-8:12 pm
2 stops26h 57m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$151
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Wed 1/13
10:57 am-5:16 pm
1 stop5h 19m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$163
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Sat 10/17
4:07 pm-10:51 pm
1 stop5h 44m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$163
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Thu 11/12
6:52 pm-11:53 pm
1 stop4h 01m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$163
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Wed 1/13
11:28 am-11:19 pm
2 stops10h 51m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$168
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Wed 11/18
7:00 am-5:25 pm
2 stops9h 25m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$168
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Sat 10/17
5:50 am-7:35 pm
2 stops12h 45m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$174
Des MoinesMyrtle Beach
DSM Des Moines - MYR Myrtle Beach Intl
DSMMYR
Des Moines
Wed 11/18
6:00 am-7:25 pm
2 stops12h 25m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$174
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Thu 11/19
1:58 pm-10:00 pm
1 stop7h 02m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$188
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
CID-GSP
DSM-MYR
CID-CHS
DSM-CHS
DSM-CAE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to South Carolina
USIA-USSC
CID-GSP
DSM-MYR
CID-CHS
DSM-CHS
What is the cheapest month to book a flight from Iowa to South Carolina?
Currently, February is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $348). Flying from Iowa to South Carolina in March is currently the most expensive (average of $478). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Iowa to South Carolina?
Airfare is below average for this route at the moment.
Iowa to South Carolina flights typically cost between $387 and $609 in October.The cheapest round-trip price found within the last 5 days was $325 on American Airlines (Oct 28-Oct 31).
How far ahead should I book a flight from Iowa to South Carolina?
The best time to book flights from Iowa to South Carolina is 8 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 29, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Boarding
8.1
Food
7.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Overall
8.0
Boarding
8.1
Food
7.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Overall
8.0
Boarding
8.1
Food
7.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Overall
8.0
Boarding
8.1
Food
7.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Overall
8.0
Boarding
8.1
Food
7.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Related info for your journey
Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Iowa to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to South Carolina by cabin class
Find flights from Iowa to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and South Carolina flights
Browse other Iowa and South Carolina flight options. Last updated on September 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Iowa after your stay in South Carolina
Iowa to South Carolina flights
Consider these flights traveling from Iowa to South Carolina.
Top 4 airlines flying from Iowa to South Carolina
Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$455 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$435 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$260 | Average$440 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$344 | Average$412 | FlexibilityNo cancel fee | On-time63% |