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South Carolina

$90+ Cheap flights from Iowa to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/30. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Iowa to South Carolina

Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$185
(Kiwi.com)

One-way from

$90
(Kiwi.com)

Popular in

June

Cheapest in

August

Average price

$406
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
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From Iowa to South Carolina
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One-way flight from Iowa to South Carolina
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Highest demand for flights based on searches. 7% potential increase in price ($30 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Iowa to South Carolina

Cheapest flights from Iowa to South Carolina
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/108:40 amDSM - SAV
1 stop21h 53mMultiple Airlines
Fri 11/148:28 amSAV - DSM
1 stop7h 27mMultiple Airlines
Deal found 10/27$208
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/166:12 pmMLI - CLT
1 stop13h 50mMultiple Airlines
Wed 11/197:54 pmCLT - MLI
1 stop14h 22mMultiple Airlines
Deal found 10/30$209
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/172:40 pmCID - CLT
1 stop21h 52mMultiple Airlines
Thu 11/205:59 pmCLT - CID
1 stop24h 44mMultiple Airlines
Deal found 10/28$213
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:57 pmCID - CLT
1 stop14h 42mMultiple Airlines
Mon 12/88:55 amCLT - CID
1 stop9h 12mMultiple Airlines
Deal found 10/27$217
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/155:57 pmCID - CLT
1 stop19h 06mMultiple Airlines
Thu 12/187:19 pmCLT - CID
1 stop14h 13mMultiple Airlines
Deal found 10/29$230
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/108:40 amDSM - CHS
1 stop7h 26mMultiple Airlines
Fri 11/149:02 amCHS - DSM
1 stop6h 53mMultiple Airlines
Deal found 10/29$235
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:50 amCID - CHS
1 stop6h 33mDelta
Sat 12/65:00 pmCHS - CID
1 stop6h 19mDelta
Deal found 10/30$249
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/43:17 pmDSM - CAE
1 stop5h 50mUnited Airlines
Tue 12/95:24 pmCAE - DSM
1 stop5h 13mUnited Airlines
Deal found 10/29$249
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:48 pmCID - CLT
1 stop12h 14mAmerican Airlines
Sun 11/911:55 amCLT - CID
Nonstop2h 37mAmerican Airlines
Deal found 10/30$249
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:57 pmCID - CLT
1 stop14h 42mMultiple Airlines
Wed 12/172:58 pmCLT - CID
2 stops18h 10mMultiple Airlines
Deal found 10/29$252
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/267:02 pmCID - CLT
1 stop13h 20mMultiple Airlines
Wed 12/38:44 pmCLT - CID
2 stops45h 23mMultiple Airlines
Deal found 10/29$255
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:56 pmDSM - CLT
1 stop8h 03mMultiple Airlines
Mon 12/88:10 pmCLT - DSM
2 stops41h 25mMultiple Airlines
Deal found 10/30$257

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.

Fly from

Iowa

Fly to

South Carolina

Route

Depart

Return

Price

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Mon 11/10

8:40 am-7:33 am

1 stop21h 53m

Savannah/Hilton Head

Fri 11/14

8:28 am-2:55 pm

1 stop7h 27m

$208

MolineCharlotte

MLI - CLT

MLICLT

Moline Quad-City

Sun 11/16

6:12 pm-9:02 am

1 stop13h 50m

Charlotte Douglas

Wed 11/19

7:54 pm-9:16 am

1 stop14h 22m

$209

Cedar RapidsCharlotte

CID - CLT

CIDCLT

Cedar Rapids

Fri 12/5

5:57 pm-9:39 am

1 stop14h 42m

Charlotte Douglas

Mon 12/8

8:55 am-5:07 pm

1 stop9h 12m

$217

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 11/10

8:40 am-5:06 pm

1 stop7h 26m

Charleston

Fri 11/14

9:02 am-2:55 pm

1 stop6h 53m

$235

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Tue 12/2

5:50 am-1:23 pm

1 stop6h 33m

Charleston

Sat 12/6

5:00 pm-10:19 pm

1 stop6h 19m

$249

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Fri 1/16

1:26 pm-10:34 pm

1 stop8h 08m

Charleston

Sun 1/25

9:13 am-2:42 pm

1 stop6h 29m

$249

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Thu 12/4

3:17 pm-10:07 pm

1 stop5h 50m

Columbia Metropolitan

Tue 12/9

5:24 pm-9:37 pm

1 stop5h 13m

$249

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Fri 12/5

3:14 pm-11:13 pm

2 stops6h 59m

Charleston

Sun 12/7

7:00 am-12:43 pm

1 stop6h 43m

$254

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 11/10

8:40 am-5:06 pm

1 stop7h 26m

Charleston

Wed 11/19

3:09 pm-9:14 pm

2 stops31h 05m

$277

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Thu 11/13

8:02 am-1:47 pm

1 stop4h 45m

Columbia Metropolitan

Sat 11/15

10:20 am-2:19 pm

1 stop4h 59m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 60 results
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Best time to book a flight from Iowa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to South Carolina

What is the cheapest month to book a flight from Iowa to South Carolina?

Currently, May is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $166). Flying from Iowa to South Carolina in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to SC?

Find hourly flight availability from Iowa to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

One of the essential ways to save on airfare from Iowa to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 11% on airfare.

What is the cheapest day to fly from Iowa to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Iowa to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Iowa to South Carolina flight should consider departing on Monday afternoons when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Iowa to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 30, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,243 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,243 reviews
Southwest
8.0
Very good
4,243 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
7,998 reviews
Southwest
8.0
Very good
4,243 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,998 reviews
Southwest
8.0
Very good
4,243 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,035 reviews
Southwest
8.0
Very good
4,243 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Crew

8.6

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to South Carolina?

    Airlines like Delta, American Airlines, and United Airlines fly from Iowa to South Carolina in about 5h 50m. The time it takes to get you to your destination can typically vary by up to 2h 18m. The distance between Iowa and South Carolina is about 861 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Iowa to South Carolina one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $115. However, be on the lookout for offers from Allegiant Air and United Airlines, as they are both options that can get you from Iowa to South Carolina for a low price.

  • Can I find deals for flights from Iowa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Iowa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to South Carolina.

  • Can I find deals for business class flights from Iowa to South Carolina?

    Yes. Cheapflights offers flight deals from Iowa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $166). Flying from Iowa to South Carolina in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Iowa to South Carolina

Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$199Average$365FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$235Average$416FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$396FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$272Average$404FlexibilityNo cancel feeOn-time63%

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