$141+ Cheap flights from Iowa to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Nov 24 — Dec 11
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to South Carolina
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Cheapest flights from Iowa to South CarolinaExplore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:11 am -
1 stop7h 07m
Thu 11/266:00 am -
1 stop8h 12m
Deal found 10/22![American Airlines logo]()
$281
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:36 am -
1 stop3h 35m
Tue 12/810:57 am -
1 stop6h 52m
Deal found 10/23![Delta logo]()
$281
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:10 am -
2 stops10h 00m
Tue 12/82:50 pm -
2 stops8h 15m
Deal found 10/23![Southwest logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:29 pm -
1 stop13h 09m
Sun 12/1310:15 pm -
1 stop19h 41m
Deal found 10/21![Multiple Airlines logo]()
$307
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/223:26 pm -
1 stop7h 54m
Mon 12/286:33 pm -
1 stop6h 25m
Deal found 10/21![American Airlines logo]()
$311
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/93:01 pm -
1 stop4h 59m
Sat 12/125:18 pm -
1 stop6h 51m
Deal found 10/20![American Airlines logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:32 pm -
1 stop13h 06m
Tue 11/103:00 pm -
1 stop26h 39m
Deal found 10/22![Multiple Airlines logo]()
$312
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:42 am -
1 stop8h 05m
Fri 12/254:11 pm -
1 stop7h 57m
Deal found 10/21![American Airlines logo]()
$320
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:29 pm -
1 stop14h 09m
Tue 11/103:00 pm -
1 stop26h 39m
Deal found 10/22![Multiple Airlines logo]()
$320
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:09 am -
1 stop4h 14m
Sat 11/146:12 am -
1 stop4h 58m
Deal found 10/21![American Airlines logo]()
$320
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/175:00 am -
2 stops9h 44m
Fri 12/254:55 pm -
1 stop5h 28m
Deal found 10/21![United Airlines logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:30 am -
2 stops23h 08m
Fri 11/63:14 pm -
1 stop8h 01m
Deal found 10/21![Multiple Airlines logo]()
$326
Best flights from Iowa to South CarolinaDiscover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:36 am -
1 stop3h 35m
Tue 12/810:57 am -
1 stop6h 52m
Deal found 10/23![Delta logo]()
$281
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/115:55 am -
2 stops9h 25m
Tue 1/191:25 pm -
2 stops9h 10m
Deal found 10/20![Southwest logo]()
$292
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/31:40 pm -
1 stop7h 30m
Mon 2/83:36 pm -
1 stop5h 23m
Deal found 10/23![American Airlines logo]()
$315
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/66:00 am -
2 stops10h 48m
Tue 1/1211:27 am -
2 stops11h 04m
Deal found 10/24![United Airlines logo]()
$321
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3010:15 am -
1 stop6h 48m
Fri 2/56:30 am -
1 stop4h 48m
Deal found 10/20![Delta logo]()
$320
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/255:07 am -
1 stop5h 15m
Mon 3/18:05 pm -
1 stop4h 51m
Deal found 10/20![American Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/148:00 am -
1 stop4h 50m
Mon 1/182:26 pm -
1 stop5h 48m
Deal found 10/22![United Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:00 am -
1 stop9h 30m
Sun 12/67:10 pm -
1 stop4h 55m
Deal found 10/23![Southwest logo]()
$341
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/35:45 am -
2 stops10h 56m
Mon 2/85:05 pm -
1 stop5h 46m
Deal found 10/23![Delta logo]()
$320
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/141:15 pm -
1 stop7h 06m
Fri 12/184:55 pm -
1 stop7h 22m
Deal found 10/24![United Airlines logo]()
$346
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/195:45 am -
2 stops10h 56m
Wed 1/277:15 am -
2 stops9h 37m
Deal found 10/22![Delta logo]()
$321
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/311:38 am -
1 stop7h 16m
Sun 12/68:34 pm -
1 stop4h 28m
Deal found 10/25![American Airlines logo]()
$370
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/205:20 am -
2 stops10h 05m
Tue 2/2310:55 am -
2 stops10h 45m
Deal found 10/23![Southwest logo]()
$373
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:00 am -
2 stops8h 11m
Sat 11/1411:27 am -
2 stops8h 49m
Deal found 10/21![United Airlines logo]()
$358
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:41 am -
1 stop6h 36m
Tue 1/57:01 am -
1 stop5h 00m
Deal found 10/25![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/213:20 pm -
1 stop7h 52m
Wed 11/2512:17 pm -
1 stop7h 38m
Deal found 10/24![American Airlines logo]()
$398
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/271:02 pm -
2 stops9h 17m
Sat 3/64:50 pm -
1 stop6h 43m
Deal found 10/20![United Airlines logo]()
$364
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:15 am -
1 stop4h 53m
Sat 11/216:04 pm -
1 stop6h 05m
Deal found 10/21![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/93:01 pm -
1 stop4h 59m
Sat 12/126:12 am -
2 stops6h 46m
Deal found 10/20![American Airlines logo]()
$401
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/65:10 am -
1 stop4h 15m
Wed 1/136:00 am -
2 stops11h 51m
Deal found 10/24![Delta logo]()
$340
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:00 am -
2 stops10h 08m
Wed 11/1112:22 pm -
2 stops10h 33m
Deal found 10/23![United Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/1111:00 am -
2 stops8h 14m
Wed 1/207:15 am -
2 stops9h 37m
Deal found 10/22![Delta logo]()
$345
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/303:00 pm -
1 stop5h 59m
Wed 2/36:30 am -
1 stop5h 11m
Deal found 10/20![United Airlines logo]()
$381
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/158:00 am -
2 stops14h 59m
Tue 1/56:00 am -
2 stops10h 51m
Deal found 10/22![United Airlines logo]()
$391
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/75:45 am -
2 stops11h 18m
Mon 1/1112:15 pm -
2 stops11h 41m
Deal found 10/23![Delta logo]()
$359
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/241:12 pm -
1 stop4h 05m
Tue 3/23:07 pm -
2 stops9h 52m
Deal found 10/23![American Airlines logo]()
$492
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/302:43 pm -
1 stop5h 20m
Wed 2/35:29 pm -
1 stop5h 02m
Deal found 10/24![United Airlines logo]()
$391
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/55:10 am -
1 stop4h 15m
Fri 1/155:18 pm -
1 stop6h 13m
Deal found 10/24![Delta logo]()
$365
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:51 pm -
2 stops10h 04m
Tue 11/108:07 am -
1 stop7h 10m
Deal found 10/20![American Airlines logo]()
$505
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/215:00 am -
2 stops9h 44m
Mon 12/286:39 pm -
1 stop5h 38m
Deal found 10/20![United Airlines logo]()
$394
Last-minute flights from Iowa to South CarolinaDiscover last-minute flight deals from Iowa to South Carolina. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to South Carolina. Data last updated October 25, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:32 pm -
1 stop13h 06m
Tue 11/103:00 pm -
1 stop26h 39m
Deal found 10/22![Multiple Airlines logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:30 am -
2 stops23h 08m
Fri 11/63:14 pm -
1 stop8h 01m
Deal found 10/21![Multiple Airlines logo]()
$326
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:30 am -
2 stops23h 08m
Wed 11/47:54 pm -
1 stop20h 31m
Deal found 10/21![Multiple Airlines logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:29 pm -
1 stop14h 09m
Tue 11/103:00 pm -
1 stop26h 39m
Deal found 10/22![Multiple Airlines logo]()
$320
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:09 am -
1 stop4h 14m
Sat 11/146:12 am -
1 stop4h 58m
Deal found 10/21![American Airlines logo]()
$320
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:15 am -
1 stop4h 53m
Sat 11/216:04 pm -
1 stop6h 05m
Deal found 10/21![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:11 am -
1 stop7h 07m
Thu 11/266:00 am -
1 stop8h 12m
Deal found 10/22![American Airlines logo]()
$281
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:00 am -
1 stop7h 58m
Tue 11/248:35 pm -
1 stop4h 51m
Deal found 10/24![American Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:00 am -
1 stop5h 26m
Thu 11/267:00 am -
1 stop5h 34m
Deal found 10/23![American Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/233:14 pm -
2 stops7h 45m
Thu 11/268:30 am -
1 stop6h 47m
Deal found 10/23![United Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:36 am -
1 stop3h 35m
Tue 12/810:57 am -
1 stop6h 52m
Deal found 10/23![Delta logo]()
$281
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:10 am -
2 stops10h 00m
Tue 12/82:50 pm -
2 stops8h 15m
Deal found 10/23![Southwest logo]()
$291
One-way flights from Iowa to South CarolinaSearch for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:30 am -
1 stop4h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Delta logo]()
$141
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/174:25 pm -
2 stops5h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Southwest logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:29 pm -
1 stop13h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Allegiant Air logo]()
$159
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:00 am -
2 stops11h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Southwest logo]()
$191
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/213:20 pm -
1 stop7h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![American Airlines logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/208:00 am -
1 stop8h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Allegiant Air logo]()
$214
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/123:31 pm -
1 stop5h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![American Airlines logo]()
$217
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/209:25 am -
1 stop4h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![American Airlines logo]()
$219
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/255:30 am -
1 stop4h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![American Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/85:58 pm -
1 stop19h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Allegiant Air logo]()
$222
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/185:10 am -
2 stops13h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Southwest logo]()
$230
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/195:20 am -
2 stops15h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Southwest logo]()
$235
Find flight deals from Iowa to South Carolina
Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated October 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $241 (Kiwi.com) |
One-way from | $141 (Delta) |
Popular in | July |
Cheapest in | November |
Average price | $353 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Thu 11/12
5:30 am-1:15 pm
1 stop6h 45m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$141
Cedar RapidsGreenville
CID Cedar Rapids - GSP Greenville
CIDGSP
Cedar Rapids
Wed 11/4
5:29 pm-7:53 am
1 stop13h 24m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$159
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Fri 12/25
6:00 am-6:10 pm
2 stops11h 10m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$191
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Sat 11/21
3:20 pm-12:12 am
1 stop7h 52m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$208
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Thu 11/12
3:31 pm-9:58 pm
1 stop5h 27m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$217
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Fri 11/20
9:25 am-3:18 pm
1 stop4h 53m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$219
Cedar RapidsGreenville
CID Cedar Rapids - GSP Greenville
CIDGSP
Cedar Rapids
Sun 11/8
5:58 pm-2:40 pm
1 stop19h 42m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$222
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Sat 12/19
5:20 am-10:00 pm
2 stops15h 40m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$235
Quickest round-trip
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Fri 12/18
6:53 pm-11:47 pm
1 stop3h 54m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$239
Des MoinesGreenville
DSM Des Moines - GSP Greenville
DSMGSP
Des Moines
Sat 12/19
6:43 pm-11:59 pm
1 stop4h 16m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$249
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
DSM-CHS
DSM-GSP
CID-CHS
CID-MYR
DSM-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to South Carolina
USIA-USSC
DSM-CHS
DSM-GSP
CID-CHS
CID-MYR
What is the cheapest month to book a flight from Iowa to South Carolina?
Currently, February is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $330). Flying from Iowa to South Carolina in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Iowa to South Carolina?
Airfare is below average for this route at the moment.
Iowa to South Carolina flights typically cost between $404 and $588 in January.The cheapest round-trip price found within the last 5 days was $241 on Multiple Airlines (Jan 11-Jan 19).
How far ahead should I book a flight from Iowa to South Carolina?
The best time to book flights from Iowa to South Carolina is 7 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 25, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
7.9
Entertainment
7.4
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
7.9
Entertainment
7.4
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
7.9
Entertainment
7.4
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
7.9
Entertainment
7.4
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
7.9
Entertainment
7.4
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Related info for your journey
Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Iowa to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to South Carolina by cabin class
Find flights from Iowa to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and South Carolina flights
Browse other Iowa and South Carolina flight options. Last updated on October 25, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Iowa after your stay in South Carolina
Iowa to South Carolina flights
Consider these flights traveling from Iowa to South Carolina.
Top 4 airlines flying from Iowa to South Carolina
Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$486 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$435 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$260 | Average$408 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$344 | Average$443 | FlexibilityNo cancel fee | On-time63% |