$70+ Cheap flights from Iowa to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/17. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Mar 20 — Mar 271
1 adult, Economy
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Find cheap flights from Iowa to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to South Carolina
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Cheapest flights from Iowa to South CarolinaExplore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 18, 2026.
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:41 pm
CID
- CLT
1 stop12h 40m
Multiple Airlines
Fri 4/109:05 am
CLT
- CID
1 stop9h 50m
Multiple Airlines
Deal found 2/17![Multiple Airlines logo]()
$175
This Trip.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:59 pm
OMA
- CLT
1 stop20h 55m
Frontier
Wed 4/157:49 pm
CLT
- OMA
1 stop25h 25m
Frontier
Deal found 2/17![Frontier logo]()
$176
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:45 pm
CID
- CLT
1 stop14h 32m
Multiple Airlines
Thu 5/79:24 pm
CLT
- CID
1 stop21h 31m
Multiple Airlines
Deal found 2/16![Multiple Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:45 pm
CID
- CLT
1 stop14h 32m
Multiple Airlines
Fri 4/248:56 am
CLT
- CID
1 stop9h 59m
Multiple Airlines
Deal found 2/15![Multiple Airlines logo]()
$192
This CheapOair deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:20 pm
DSM
- CLT
1 stop25h 32m
Frontier
Sun 4/197:49 pm
CLT
- DSM
1 stop18h 40m
Frontier
Deal found 2/16![Frontier logo]()
$192
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:45 pm
CID
- CLT
1 stop14h 32m
Multiple Airlines
Fri 5/86:00 am
CLT
- CID
1 stop12h 55m
Multiple Airlines
Deal found 2/16![Multiple Airlines logo]()
$202
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/236:57 pm
CID
- CLT
1 stop12h 24m
Multiple Airlines
Mon 3/308:56 am
CLT
- CID
1 stop10h 11m
Multiple Airlines
Deal found 2/17![Multiple Airlines logo]()
$205
This CheapOair deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:00 am
DSM
- CLT
1 stop20h 03m
Frontier
Fri 3/137:43 pm
CLT
- DSM
1 stop24h 33m
Frontier
Deal found 2/18![Frontier logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:45 pm
CID
- CLT
1 stop14h 32m
Multiple Airlines
Mon 5/118:56 am
CLT
- CID
1 stop9h 59m
Multiple Airlines
Deal found 2/16![Multiple Airlines logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:45 pm
CID
- CLT
1 stop25h 53m
Multiple Airlines
Thu 5/149:24 pm
CLT
- CID
1 stop21h 31m
Multiple Airlines
Deal found 2/16![Multiple Airlines logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:59 pm
OMA
- CLT
1 stop18h 53m
Multiple Airlines
Wed 5/208:05 pm
CLT
- OMA
1 stop14h 12m
Multiple Airlines
Deal found 2/17![Multiple Airlines logo]()
$217
This CheapOair deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- CLT
1 stop21h 07m
Frontier
Mon 3/99:28 pm
CLT
- DSM
1 stop13h 37m
Frontier
Deal found 2/15![Frontier logo]()
$235
Best flights from Iowa to South CarolinaDiscover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 18, 2026.
Discover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 18, 2026.
This CheapOair deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:20 pm
DSM
- CLT
1 stop25h 32m
Frontier
Sun 4/197:49 pm
CLT
- DSM
1 stop18h 40m
Frontier
Deal found 2/16![Frontier logo]()
$192
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/236:57 pm
CID
- CLT
1 stop12h 24m
Multiple Airlines
Mon 3/308:56 am
CLT
- CID
1 stop10h 11m
Multiple Airlines
Deal found 2/17![Multiple Airlines logo]()
$205
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:40 pm
CID
- CHS
1 stop5h 45m
United Airlines
Tue 4/218:00 am
CHS
- CID
1 stop5h 47m
United Airlines
Deal found 2/17![United Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:48 pm
CID
- SAV
1 stop6h 09m
American Airlines
Mon 4/68:20 pm
SAV
- CID
1 stop4h 53m
American Airlines
Deal found 2/15![American Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:45 am
CID
- SAV
1 stop6h 25m
Delta
Tue 6/23:31 pm
SAV
- CID
1 stop6h 43m
Delta
Deal found 2/16![Delta logo]()
$269
This Southwest deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/412:55 pm
OMA
- CLT
1 stop8h 55m
Southwest
Tue 4/77:35 am
CLT
- OMA
1 stop5h 10m
Southwest
Deal found 2/18![Southwest logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:45 pm
CID
- CLT
2 stops14h 29m
Multiple Airlines
Thu 5/79:24 pm
CLT
- CID
1 stop21h 31m
Multiple Airlines
Deal found 2/16![Multiple Airlines logo]()
$219
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/59:46 am
CID
- SAV
1 stop7h 03m
United Airlines
Sat 5/94:50 pm
SAV
- CID
1 stop5h 43m
United Airlines
Deal found 2/17![United Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:00 am
CID
- SAV
1 stop6h 23m
American Airlines
Sat 5/96:11 pm
SAV
- CID
1 stop6h 42m
American Airlines
Deal found 2/15![American Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/64:13 pm
CID
- CLT
1 stop25h 15m
Frontier
Sun 3/87:43 pm
CLT
- CID
1 stop20h 44m
Frontier
Deal found 2/16![Frontier logo]()
$269
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2112:55 pm
CID
- CHS
1 stop4h 53m
Delta
Wed 3/255:27 am
CHS
- CID
2 stops6h 44m
Delta
Deal found 2/16![Delta logo]()
$274
This United Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:00 am
CID
- SAV
1 stop5h 18m
United Airlines
Wed 7/223:14 pm
SAV
- CID
1 stop7h 20m
United Airlines
Deal found 2/18![United Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/251:14 pm
CID
- SAV
1 stop8h 17m
American Airlines
Tue 4/287:00 am
SAV
- CID
1 stop6h 29m
American Airlines
Deal found 2/16![American Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/213:10 pm
OMA
- CLT
1 stop5h 45m
Southwest
Tue 2/248:25 am
CLT
- OMA
1 stop4h 10m
Southwest
Deal found 2/16![Southwest logo]()
$303
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:33 am
CID
- CHS
1 stop5h 23m
Delta
Sat 3/75:27 am
CHS
- CID
2 stops9h 38m
Delta
Deal found 2/16![Delta logo]()
$284
This United Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/112:39 pm
CID
- SAV
1 stop5h 29m
United Airlines
Sat 4/258:00 am
SAV
- CID
1 stop7h 01m
United Airlines
Deal found 2/15![United Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:05 am
DSM
- CLT
Nonstop2h 25m
American Airlines
Sat 5/164:39 pm
CLT
- DSM
1 stop8h 10m
American Airlines
Deal found 2/15![American Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/61:50 pm
OMA
- CLT
1 stop4h 35m
Southwest
Mon 4/137:00 pm
CLT
- OMA
1 stop5h 15m
Southwest
Deal found 2/15![Southwest logo]()
$303
This United Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/221:28 pm
CID
- SAV
1 stop4h 47m
United Airlines
Tue 4/288:00 am
SAV
- CID
1 stop6h 59m
United Airlines
Deal found 2/15![United Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/124:18 pm
CID
- CHS
2 stops6h 51m
Delta
Wed 5/204:55 pm
CHS
- CID
1 stop5h 19m
Delta
Deal found 2/16![Delta logo]()
$299
This Southwest deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/164:35 pm
OMA
- CLT
1 stop4h 50m
Southwest
Tue 3/177:45 am
CLT
- OMA
1 stop4h 55m
Southwest
Deal found 2/17![Southwest logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/102:46 pm
CID
- CLT
2 stops16h 34m
Multiple Airlines
Mon 4/136:00 am
CLT
- CID
1 stop12h 55m
Multiple Airlines
Deal found 2/16![Multiple Airlines logo]()
$336
This American Airlines deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:00 am
MLI
- CLT
Nonstop2h 18m
American Airlines
Wed 7/222:35 pm
CLT
- MLI
Nonstop2h 20m
American Airlines
Deal found 2/14![American Airlines logo]()
$293
This United Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/118:00 am
CID
- CHS
1 stop4h 55m
United Airlines
Tue 4/148:00 am
CHS
- CID
1 stop5h 47m
United Airlines
Deal found 2/16![United Airlines logo]()
$272
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:37 pm
OMA
- MYR
1 stop4h 37m
Delta
Tue 4/281:43 pm
MYR
- OMA
1 stop7h 46m
Delta
Deal found 2/18![Delta logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:41 pm
CID
- CLT
2 stops28h 55m
Multiple Airlines
Mon 4/69:15 am
CLT
- CID
1 stop9h 36m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$352
This Southwest deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:40 am
DSM
- CHS
2 stops11h 15m
Southwest
Wed 4/87:15 am
CHS
- DSM
1 stop5h 10m
Southwest
Deal found 2/15![Southwest logo]()
$322
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/184:25 pm
MLI
- CLT
Nonstop2h 21m
American Airlines
Wed 7/298:35 pm
CLT
- MLI
Nonstop2h 22m
American Airlines
Deal found 2/17![American Airlines logo]()
$293
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:09 pm
OMA
- MYR
1 stop4h 55m
Delta
Tue 3/316:54 pm
MYR
- OMA
1 stop6h 17m
Delta
Deal found 2/17![Delta logo]()
$305
This Southwest deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/176:40 am
DSM
- CHS
2 stops11h 15m
Southwest
Tue 3/244:35 pm
CHS
- DSM
1 stop6h 30m
Southwest
Deal found 2/15![Southwest logo]()
$322
Last-minute flights from Iowa to South CarolinaDiscover last-minute flight deals from Iowa to South Carolina. Data last updated February 18, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to South Carolina. Data last updated February 18, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/37:44 pm
DSM
- CLT
1 stop11h 18m
American Airlines
Wed 3/411:30 am
CLT
- DSM
Nonstop2h 37m
American Airlines
Deal found 2/16![American Airlines logo]()
$257
This CheapOair deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:27 pm
DSM
- CLT
1 stop22h 21m
Frontier
Sun 3/87:43 pm
CLT
- DSM
1 stop24h 33m
Frontier
Deal found 2/18![Frontier logo]()
$261
This CheapOair deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- CLT
1 stop21h 07m
Frontier
Mon 3/99:28 pm
CLT
- DSM
1 stop13h 37m
Frontier
Deal found 2/15![Frontier logo]()
$235
This CheapOair deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- CLT
1 stop21h 07m
Frontier
Sat 3/142:45 pm
CLT
- DSM
1 stop20h 00m
Frontier
Deal found 2/17![Frontier logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/96:59 pm
CID
- CLT
1 stop12h 27m
Multiple Airlines
Thu 3/127:48 pm
CLT
- CID
1 stop14h 17m
Multiple Airlines
Deal found 2/17![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/96:59 pm
CID
- CLT
1 stop18h 18m
Multiple Airlines
Mon 3/166:00 am
CLT
- CID
1 stop13h 07m
Multiple Airlines
Deal found 2/14![Multiple Airlines logo]()
$258
This CheapOair deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:00 am
DSM
- CLT
1 stop20h 03m
Frontier
Fri 3/137:43 pm
CLT
- DSM
1 stop24h 33m
Frontier
Deal found 2/18![Frontier logo]()
$206
This Delta deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:32 am
CID
- SAV
1 stop6h 30m
Delta
Mon 3/164:57 pm
SAV
- CID
1 stop6h 22m
Delta
Deal found 2/15![Delta logo]()
$269
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:18 pm
OMA
- CLT
1 stop14h 00m
American Airlines
Tue 3/171:57 pm
CLT
- OMA
Nonstop2h 50m
American Airlines
Deal found 2/17![American Airlines logo]()
$243
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/214:48 pm
CID
- CHS
1 stop5h 13m
American Airlines
Fri 3/273:48 pm
CHS
- CID
1 stop8h 11m
American Airlines
Deal found 2/16![American Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/236:57 pm
CID
- CLT
1 stop12h 24m
Multiple Airlines
Mon 3/308:56 am
CLT
- CID
1 stop10h 11m
Multiple Airlines
Deal found 2/17![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2310:26 am
DSM
- CLT
1 stop20h 37m
Multiple Airlines
Tue 3/243:12 pm
CLT
- DSM
2 stops29h 04m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$244
One-way flights from Iowa to South CarolinaSearch for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated February 18, 2026.
Search for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated February 18, 2026.
This Trip.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:49 pm
OMA
- CLT
1 stop19h 07m
Frontier
Deal found 2/18![Frontier logo]()
$70
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:45 pm
CID
- CLT
1 stop18h 28m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$86
This Trip.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:59 pm
OMA
- CLT
1 stop18h 53m
Frontier
Deal found 2/15![Frontier logo]()
$89
This Trip.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:20 pm
DSM
- CLT
1 stop25h 32m
Frontier
Deal found 2/17![Frontier logo]()
$89
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:45 pm
CID
- CLT
1 stop12h 36m
Multiple Airlines
Deal found 2/17![Multiple Airlines logo]()
$90
This CheapOair deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1710:40 am
DSM
- CLT
1 stop25h 15m
Frontier
Deal found 2/18![Frontier logo]()
$92
This Trip.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/38:59 pm
OMA
- CLT
1 stop19h 24m
Frontier
Deal found 2/18![Frontier logo]()
$97
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/159:00 am
DSM
- CLT
1 stop10h 06m
American Airlines
Deal found 2/15![American Airlines logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:59 pm
OMA
- CLT
1 stop20h 55m
Frontier
Deal found 2/17![Frontier logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:14 pm
DSM
- CLT
1 stop21h 40m
Frontier
Deal found 2/15![Frontier logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:45 pm
CID
- CLT
1 stop26h 48m
Multiple Airlines
Deal found 2/14![Multiple Airlines logo]()
$107
This Southwest deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:40 pm
OMA
- CLT
1 stop4h 10m
Southwest
Deal found 2/18![Southwest logo]()
$109
Find flight deals from Iowa to South Carolina
Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated February 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $175 (Kiwi.com) |
One-way from | $70 (Trip.com) |
Popular in | November |
Cheapest in | January |
Average price | $354 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 18, 2026.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.
Fly from
Iowa
Fly to
South Carolina
Route
Depart
Return
Price
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
Fri 4/17
2:20 pm-4:52 pm
1 stop25h 32m
Charlotte Douglas
Sun 4/19
7:49 pm-1:29 pm
1 stop18h 40m
$192
Cedar RapidsCharlotte
CID - CLT
CIDCLT
Cedar Rapids
Mon 3/23
6:57 pm-8:21 am
1 stop12h 24m
Charlotte Douglas
Mon 3/30
8:56 am-6:07 pm
1 stop10h 11m
$205
Cedar RapidsCharlotte
CID - CLT
CIDCLT
Cedar Rapids
Mon 5/4
6:45 pm-10:14 am
2 stops14h 29m
Charlotte Douglas
Thu 5/7
9:24 pm-5:55 pm
1 stop21h 31m
$219
Cedar RapidsCharleston
CID - CHS
CIDCHS
Cedar Rapids
Fri 4/17
2:40 pm-9:25 pm
1 stop5h 45m
Charleston
Tue 4/21
8:00 am-12:47 pm
1 stop5h 47m
$269
Cedar RapidsSavannah
CID - SAV
CIDSAV
Cedar Rapids
Fri 4/3
4:48 pm-11:57 pm
1 stop6h 09m
Savannah/Hilton Head
Mon 4/6
8:20 pm-12:13 am
1 stop4h 53m
$269
Cedar RapidsSavannah
CID - SAV
CIDSAV
Cedar Rapids
Fri 5/29
5:45 am-1:10 pm
1 stop6h 25m
Savannah/Hilton Head
Tue 6/2
3:31 pm-9:14 pm
1 stop6h 43m
$269
Cedar RapidsSavannah
CID - SAV
CIDSAV
Cedar Rapids
Tue 5/5
9:46 am-5:49 pm
1 stop7h 03m
Savannah/Hilton Head
Sat 5/9
4:50 pm-9:33 pm
1 stop5h 43m
$269
Cedar RapidsSavannah
CID - SAV
CIDSAV
Cedar Rapids
Tue 5/5
6:00 am-1:23 pm
1 stop6h 23m
Savannah/Hilton Head
Sat 5/9
6:11 pm-11:53 pm
1 stop6h 42m
$269
Cedar RapidsCharlotte
CID - CLT
CIDCLT
Cedar Rapids
Fri 3/6
4:13 pm-6:28 pm
1 stop25h 15m
Charlotte Douglas
Sun 3/8
7:43 pm-3:27 pm
1 stop20h 44m
$269
Cedar RapidsSavannah
CID - SAV
CIDSAV
Cedar Rapids
Wed 7/15
8:00 am-2:18 pm
1 stop5h 18m
Savannah/Hilton Head
Wed 7/22
3:14 pm-9:34 pm
1 stop7h 20m
$269
Showing 1-10 of 60 results
Best time to book a flight from Iowa to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
CID-CLT
DSM-CLT
OMA-CLT
CID-CHS
CID-SAV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to South Carolina
USIA-USSC
CID-CLT
DSM-CLT
OMA-CLT
CID-CHS
What is the cheapest month to book a flight from Iowa to South Carolina?
Currently, May is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $166). Flying from Iowa to South Carolina in December is currently the most expensive (average of $256). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from IA to SC?
Find hourly flight availability from Iowa to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 18, 2026.
One of the essential ways to save on airfare from Iowa to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 34% on airfare.
What is the cheapest day to fly from Iowa to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Iowa to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Iowa to South Carolina flight should consider departing on Monday afternoons when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 18, 2026.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Overall
8.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Overall
8.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Overall
8.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Overall
8.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Food
7.0
Overall
8.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Iowa to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to South Carolina by cabin class
Find flights from Iowa to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and South Carolina flights
Browse other Iowa and South Carolina flight options. Last updated on February 18, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Iowa after your stay in South Carolina
Iowa to South Carolina flights
Consider these flights traveling from Iowa to South Carolina.
Top 4 airlines flying from Iowa to South Carolina
Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$166 | Average$381 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$227 | Average$388 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$228 | Average$399 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$272 | Average$404 | FlexibilityNo cancel fee | On-time63% |