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South Carolina

$78+ Cheap flights from Iowa to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Dec 19 — Dec 261
Fri 12/19
Fri 12/26
1 adult, Economy
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Cheap flight deals from Iowa to South Carolina

Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated November 19, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$182
(Kiwi.com)

One-way from

$78
(Kiwi.com)

Popular in

June

Cheapest in

August

Average price

$467
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
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From Iowa to South Carolina
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One-way flight from Iowa to South Carolina
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Highest demand for flights based on searches. 8% potential increase in price ($38 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Iowa to South Carolina

Cheapest flights from Iowa to South Carolina
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 19, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/88:00 amDSM - CLT
2 stops29h 03mMultiple Airlines
Thu 12/115:44 pmCLT - DSM
1 stop26h 19mMultiple Airlines
Deal found 11/18$182
This Kiwi.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:24 pmOMA - CLT
1 stop25h 25mMultiple Airlines
Sun 12/710:33 pmCLT - OMA
1 stop21h 11mMultiple Airlines
Deal found 11/18$223
This Kiwi.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/267:02 pmCID - CHS
1 stop26h 03mMultiple Airlines
Thu 12/49:49 pmCHS - CID
1 stop20h 18mMultiple Airlines
Deal found 11/17$241
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1111:10 amMLI - CHS
1 stop6h 14mAmerican Airlines
Sun 12/147:00 amCHS - MLI
1 stop8h 59mAmerican Airlines
Deal found 11/17$249
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:34 amDSM - CAE
1 stop5h 34mDelta
Wed 12/179:59 amCAE - DSM
1 stop4h 32mDelta
Deal found 11/17$249
This Kiwi.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/15:42 pmCID - CLT
1 stop15h 08mMultiple Airlines
Thu 12/42:58 pmCLT - CID
1 stop27h 09mMultiple Airlines
Deal found 11/18$263
This United Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/31:00 pmMLI - CHS
1 stop5h 30mUnited Airlines
Sun 12/76:05 amCHS - MLI
1 stop5h 10mUnited Airlines
Deal found 11/18$279
This Delta deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:50 amCID - CHS
1 stop6h 33mDelta
Sat 12/65:00 pmCHS - CID
1 stop6h 19mDelta
Deal found 11/18$279
This American Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:18 pmDSM - CAE
1 stop6h 52mAmerican Airlines
Sat 12/68:11 pmCAE - DSM
1 stop5h 14mAmerican Airlines
Deal found 11/16$279
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/245:54 amCID - CHS
1 stop4h 52mDelta
Wed 12/35:00 pmCHS - CID
1 stop6h 19mDelta
Deal found 11/17$281
This United Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:17 pmDSM - CAE
1 stop5h 50mUnited Airlines
Sat 12/62:22 pmCAE - DSM
2 stops10h 22mUnited Airlines
Deal found 11/16$284
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2412:29 pmCID - CHS
2 stops9h 21mDelta
Fri 12/56:31 pmCHS - CID
1 stop4h 48mDelta
Deal found 11/17$286

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 19, 2025.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.

Fly from

Iowa

Fly to

South Carolina

Route

Depart

Return

Price

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Thu 1/29

6:15 am-11:39 am

1 stop4h 24m

Charleston

Sun 2/1

5:41 pm-9:33 pm

1 stop4h 52m

$219

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Sat 2/21

4:50 pm-11:58 pm

1 stop6h 08m

Charleston

Wed 2/25

5:36 pm-11:00 pm

1 stop6h 24m

$219

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Wed 1/7

5:35 am-1:37 pm

1 stop7h 02m

Charleston

Wed 1/14

5:25 am-11:31 am

2 stops7h 06m

$224

Cedar RapidsCharlotte

CID - CLT

CIDCLT

Cedar Rapids

Mon 1/26

9:15 am-6:01 pm

1 stop7h 46m

Charlotte Douglas

Thu 1/29

11:12 am-8:25 am

2 stops22h 13m

$229

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Wed 1/7

12:11 pm-11:55 pm

2 stops10h 44m

Charleston

Tue 1/13

5:25 am-11:31 am

2 stops7h 06m

$229

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Fri 1/16

3:41 pm-11:07 pm

2 stops6h 26m

Charleston

Sun 1/25

6:10 am-3:11 pm

2 stops10h 01m

$229

Cedar RapidsCharlotte

CID - CLT

CIDCLT

Cedar Rapids

Mon 1/26

9:15 am-9:17 pm

1 stop11h 02m

Charlotte Douglas

Sun 2/1

8:04 pm-5:45 pm

1 stop22h 41m

$239

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Wed 1/7

5:35 am-1:37 pm

1 stop7h 02m

Charleston

Sat 1/10

5:25 am-2:12 pm

2 stops9h 47m

$239

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Sat 1/10

6:30 am-2:18 pm

1 stop6h 48m

Charleston

Wed 1/14

5:25 am-3:35 pm

2 stops11h 10m

$239

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Sat 1/24

2:55 pm-11:55 pm

2 stops8h 00m

Charleston

Wed 1/28

3:28 pm-9:47 pm

1 stop7h 19m

$239

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/18

Showing 1-10 of 60 results
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Best time to book a flight from Iowa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to South Carolina

What is the cheapest month to book a flight from Iowa to South Carolina?

Currently, May is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $166). Flying from Iowa to South Carolina in December is currently the most expensive (average of $266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to SC?

Find hourly flight availability from Iowa to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 19, 2025.

One of the essential ways to save on airfare from Iowa to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 11% on airfare.

What is the cheapest day to fly from Iowa to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Iowa to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Iowa to South Carolina flight should consider departing on Monday afternoons when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 19, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,249 reviews

Overall

8.0

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,249 reviews
Southwest
8.0
Very good
4,249 reviews

Overall

8.0

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
8,004 reviews
Southwest
8.0
Very good
4,249 reviews

Overall

8.0

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
9,023 reviews
Southwest
8.0
Very good
4,249 reviews

Overall

8.0

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,046 reviews
Southwest
8.0
Very good
4,249 reviews

Overall

8.0

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to South Carolina?

    Airlines like American Airlines, Delta, and United Airlines fly from Iowa to South Carolina in about 4h 24m. The time it takes to get you to your destination can typically vary by up to 7h 29m. The distance between Iowa and South Carolina is about 824 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Iowa to South Carolina one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $78. However, be on the lookout for offers from Delta and American Airlines, as they are both options that can get you from Iowa to South Carolina for a low price.

  • Can I find deals for flights from Iowa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Iowa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to South Carolina.

  • Can I find deals for business class flights from Iowa to South Carolina?

    Yes. Cheapflights offers flight deals from Iowa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $166). Flying from Iowa to South Carolina in December is currently the most expensive (average of $266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Iowa to South Carolina

Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 19, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$199Average$362FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$235Average$416FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$399FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$272Average$404FlexibilityNo cancel feeOn-time63%

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