$112+ Cheap flights from Iowa to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
jul. 31 — ago. 71
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Iowa to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to South Carolina
Cheapest
Best
Last-minute
One-way
Cheapest flights from Iowa to South CarolinaExplore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 1, 2026.
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 1, 2026.
This Delta deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/85:00 pm
MLI
- CLT
1 stop5h 53m
Delta
jue. 10/156:45 am
CLT
- MLI
1 stop4h 41m
Delta
Deal found 6/26![Delta logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/106:24 pm
CID
- CLT
1 stop25h 49m
Multiple Airlines
jue. 8/136:41 pm
CLT
- CID
1 stop23h 53m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$257
This American Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/141:37 pm
CID
- MYR
1 stop4h 52m
American Airlines
mié. 10/218:14 pm
MYR
- CID
1 stop4h 44m
American Airlines
Deal found 6/29![American Airlines logo]()
$261
This Delta deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/86:26 am
OMA
- CLT
1 stop4h 49m
Delta
mar. 9/157:16 pm
CLT
- OMA
1 stop4h 36m
Delta
Deal found 6/26![Delta logo]()
$273
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/225:50 am
CID
- MYR
1 stop6h 10m
Delta
mié. 8/57:02 pm
MYR
- CID
1 stop4h 21m
Delta
Deal found 6/30![Delta logo]()
$285
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/1210:49 am
CID
- CHS
1 stop20h 49m
Multiple Airlines
jue. 8/137:47 pm
CHS
- CID
1 stop22h 47m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$286
This Delta deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/86:00 am
DSM
- CLT
1 stop5h 17m
Delta
sáb. 8/1511:50 am
CLT
- DSM
1 stop4h 26m
Delta
Deal found 6/26![Delta logo]()
$287
This United Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/216:00 am
CID
- MYR
1 stop7h 53m
United Airlines
mié. 8/2610:23 am
MYR
- CID
2 stops11h 56m
United Airlines
Deal found 6/27![United Airlines logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/510:49 am
CID
- CHS
1 stop20h 49m
Multiple Airlines
mar. 8/113:13 pm
CHS
- CID
1 stop19h 46m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/106:07 pm
DSM
- CLT
1 stop26h 06m
Multiple Airlines
mié. 8/126:41 pm
CLT
- DSM
2 stops29h 38m
Multiple Airlines
Deal found 6/26![Multiple Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/146:07 pm
DSM
- CLT
1 stop26h 06m
Multiple Airlines
dom. 9/139:22 am
CLT
- DSM
1 stop11h 35m
Multiple Airlines
Deal found 6/26![Multiple Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/125:40 am
DSM
- MYR
1 stop6h 53m
Delta
mié. 8/196:00 am
MYR
- DSM
1 stop5h 43m
Delta
Deal found 6/29![Delta logo]()
$307
Best flights from Iowa to South CarolinaDiscover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated julio 1, 2026.
Discover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated julio 1, 2026.
This Delta deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 8/256:00 am
MLI
- CLT
1 stop4h 03m
Delta
lun. 8/3111:50 am
CLT
- MLI
1 stop5h 35m
Delta
Deal found 6/26![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/17:15 am
DSM
- MYR
2 stops10h 55m
Southwest
mié. 9/911:00 am
MYR
- DSM
2 stops11h 00m
Southwest
Deal found 6/28![Southwest logo]()
$317
This United Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/56:30 am
CID
- CHS
2 stops6h 57m
United Airlines
mar. 8/1110:19 am
CHS
- CID
2 stops12h 00m
United Airlines
Deal found 6/29![United Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/105:00 am
CID
- MYR
1 stop5h 34m
American Airlines
sáb. 8/155:27 pm
MYR
- CID
1 stop5h 15m
American Airlines
Deal found 6/30![American Airlines logo]()
$328
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/106:24 pm
CID
- CLT
1 stop25h 49m
Multiple Airlines
mié. 8/1210:04 pm
CLT
- CID
1 stop17h 02m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/225:50 am
CID
- MYR
1 stop6h 10m
Delta
mié. 8/57:02 pm
MYR
- CID
1 stop4h 21m
Delta
Deal found 6/30![Delta logo]()
$285
This Delta deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/54:11 pm
DSM
- CLT
1 stop6h 46m
Delta
mar. 9/86:20 am
CLT
- DSM
1 stop4h 57m
Delta
Deal found 6/26![Delta logo]()
$287
This Southwest deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 8/183:05 pm
OMA
- CLT
1 stop5h 05m
Southwest
mié. 8/1912:35 pm
CLT
- OMA
1 stop7h 45m
Southwest
Deal found 6/28![Southwest logo]()
$321
This United Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/246:02 am
OMA
- CHS
1 stop6h 56m
United Airlines
sáb. 8/298:30 am
CHS
- OMA
1 stop8h 58m
United Airlines
Deal found 6/27![United Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/282:15 pm
OMA
- CLT
1 stop6h 35m
Southwest
mié. 9/308:05 am
CLT
- OMA
1 stop4h 35m
Southwest
Deal found 6/26![Southwest logo]()
$323
This United Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 7/112:42 pm
CID
- CHS
1 stop6h 06m
United Airlines
mié. 7/153:08 pm
CHS
- CID
1 stop6h 50m
United Airlines
Deal found 6/26![United Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/711:27 am
DSM
- CHS
1 stop4h 47m
Delta
mar. 11/109:30 am
CHS
- DSM
1 stop4h 57m
Delta
Deal found 6/29![Delta logo]()
$317
This Southwest deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/35:25 am
OMA
- CLT
1 stop4h 30m
Southwest
sáb. 8/86:30 am
CLT
- OMA
1 stop4h 00m
Southwest
Deal found 6/26![Southwest logo]()
$326
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/55:13 am
CID
- MYR
1 stop5h 21m
American Airlines
jue. 9/104:57 pm
MYR
- CID
1 stop7h 21m
American Airlines
Deal found 6/30![American Airlines logo]()
$398
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 7/2410:52 am
CID
- CLT
2 stops23h 37m
Multiple Airlines
dom. 7/266:41 pm
CLT
- CID
1 stop23h 24m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$406
This Delta deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/165:45 am
CID
- CHS
1 stop4h 41m
Delta
mié. 10/215:55 pm
CHS
- CID
1 stop4h 56m
Delta
Deal found 6/26![Delta logo]()
$324
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/147:00 pm
OMA
- MYR
2 stops12h 59m
United Airlines
sáb. 9/194:00 pm
MYR
- OMA
1 stop8h 42m
United Airlines
Deal found 6/30![United Airlines logo]()
$361
This Southwest deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 7/253:35 pm
DSM
- MYR
1 stop4h 35m
Southwest
jue. 8/2710:50 am
MYR
- DSM
2 stops11h 25m
Southwest
Deal found 6/27![Southwest logo]()
$332
This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 7/247:11 am
DSM
- MYR
2 stops9h 14m
American Airlines
mar. 7/284:43 pm
MYR
- DSM
1 stop8h 15m
American Airlines
Deal found 6/26![American Airlines logo]()
$418
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 7/197:24 pm
CID
- MYR
1 stop17h 42m
Multiple Airlines
mié. 7/228:44 pm
MYR
- CID
2 stops45h 21m
Multiple Airlines
Deal found 6/27![Multiple Airlines logo]()
$426
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 7/185:45 am
CID
- CHS
1 stop6h 58m
Delta
sáb. 7/255:00 pm
CHS
- CID
1 stop6h 03m
Delta
Deal found 6/30![Delta logo]()
$324
This United Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/146:30 am
CID
- CHS
2 stops6h 57m
United Airlines
sáb. 7/182:47 pm
CHS
- CID
2 stops8h 55m
United Airlines
Deal found 6/29![United Airlines logo]()
$362
This Southwest deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/135:30 am
OMA
- MYR
2 stops7h 25m
Southwest
mié. 10/143:55 pm
MYR
- OMA
2 stops7h 10m
Southwest
Deal found 6/29![Southwest logo]()
$343
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/145:15 pm
OMA
- MYR
1 stop4h 23m
American Airlines
vie. 8/215:15 pm
MYR
- OMA
1 stop7h 23m
American Airlines
Deal found 6/30![American Airlines logo]()
$427
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/285:50 am
CID
- CHS
1 stop5h 10m
Delta
mar. 8/45:10 am
CHS
- CID
2 stops7h 10m
Delta
Deal found 6/28![Delta logo]()
$329
This Southwest deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/105:40 am
DSM
- CLT
2 stops9h 45m
Southwest
mié. 8/1212:35 pm
CLT
- DSM
2 stops9h 25m
Southwest
Deal found 6/26![Southwest logo]()
$346
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/231:41 pm
DSM
- MYR
1 stop7h 02m
American Airlines
lun. 7/274:43 pm
MYR
- DSM
1 stop8h 15m
American Airlines
Deal found 6/30![American Airlines logo]()
$427
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/296:00 am
CID
- CHS
1 stop6h 58m
United Airlines
mié. 9/24:38 pm
CHS
- CID
1 stop7h 04m
United Airlines
Deal found 6/30![United Airlines logo]()
$389
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/165:30 pm
OMA
- MYR
1 stop4h 59m
Delta
mar. 9/226:00 am
MYR
- OMA
1 stop4h 44m
Delta
Deal found 6/27![Delta logo]()
$333
This Southwest deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/132:15 pm
OMA
- CLT
1 stop6h 35m
Southwest
lun. 8/178:10 am
CLT
- OMA
1 stop6h 25m
Southwest
Deal found 6/29![Southwest logo]()
$355
Last-minute flights from Iowa to South CarolinaDiscover last-minute flight deals from Iowa to South Carolina. Data last updated julio 1, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to South Carolina. Data last updated julio 1, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/166:04 am
CID
- CHS
1 stop4h 50m
American Airlines
jue. 7/233:42 pm
CHS
- CID
1 stop8h 38m
American Airlines
Deal found 6/29![American Airlines logo]()
$324
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/204:40 pm
DSM
- MYR
1 stop16h 10m
Multiple Airlines
sáb. 7/256:23 pm
MYR
- DSM
1 stop29h 24m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$321
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/215:41 am
DSM
- MYR
1 stop4h 06m
Delta
mar. 7/214:16 pm
MYR
- DSM
1 stop7h 13m
Delta
Deal found 6/28![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/225:50 am
CID
- MYR
1 stop6h 10m
Delta
mié. 8/57:02 pm
MYR
- CID
1 stop4h 21m
Delta
Deal found 6/30![Delta logo]()
$285
This American Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/221:41 pm
DSM
- CHS
1 stop5h 09m
American Airlines
sáb. 7/257:50 pm
CHS
- DSM
1 stop5h 19m
American Airlines
Deal found 6/28![American Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/225:20 am
DSM
- CHS
2 stops11h 55m
Southwest
sáb. 7/255:30 am
CHS
- DSM
1 stop7h 05m
Southwest
Deal found 6/28![Southwest logo]()
$322
This American Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/286:04 am
CID
- CHS
1 stop4h 50m
American Airlines
mar. 8/48:21 pm
CHS
- CID
1 stop4h 28m
American Airlines
Deal found 6/28![American Airlines logo]()
$314
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/283:45 pm
DSM
- CLT
1 stop4h 30m
Southwest
mar. 8/48:05 am
CLT
- DSM
1 stop4h 45m
Southwest
Deal found 6/30![Southwest logo]()
$321
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/305:50 am
CID
- MYR
1 stop6h 10m
Delta
vie. 8/77:02 pm
MYR
- CID
1 stop4h 21m
Delta
Deal found 6/28![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/305:50 am
CID
- MYR
1 stop6h 10m
Delta
mié. 8/1211:33 am
MYR
- CID
2 stops11h 50m
Delta
Deal found 6/28![Delta logo]()
$314
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/305:50 am
CID
- MYR
1 stop6h 10m
Delta
jue. 8/67:02 pm
MYR
- CID
1 stop4h 21m
Delta
Deal found 6/28![Delta logo]()
$324
This American Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 7/316:04 am
CID
- CHS
1 stop4h 50m
American Airlines
sáb. 8/87:00 am
CHS
- CID
1 stop4h 45m
American Airlines
Deal found 6/28![American Airlines logo]()
$309
One-way flights from Iowa to South CarolinaSearch for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated julio 1, 2026.
Search for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated julio 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/275:55 pm
CID
- CLT
1 stop26h 12m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$112
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/215:09 pm
MLI
- CLT
1 stop5h 48m
Delta
Deal found 6/27![Delta logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 7/315:55 pm
CID
- CLT
1 stop26h 12m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/274:40 pm
DSM
- CLT
1 stop27h 27m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$137
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/226:25 am
OMA
- CLT
1 stop4h 52m
Delta
Deal found 6/27![Delta logo]()
$137
This Trip.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/283:01 pm
CID
- CLT
1 stop29h 18m
Frontier
Deal found 6/26![Frontier logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/239:28 am
DSM
- CHS
2 stops46h 10m
Multiple Airlines
Deal found 6/26![Multiple Airlines logo]()
$140
This CheapOair deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/282:19 pm
DSM
- CLT
1 stop25h 07m
Frontier
Deal found 6/30![Frontier logo]()
$146
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/239:50 pm
DSM
- CLT
2 stops21h 21m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$158
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/211:41 pm
DSM
- MYR
1 stop7h 02m
American Airlines
Deal found 6/27![American Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 7/245:55 pm
CID
- CLT
1 stop26h 12m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$160
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/285:20 am
DSM
- CLT
1 stop4h 50m
Southwest
Deal found 6/30![Southwest logo]()
$161
Find flight deals from Iowa to South Carolina
Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated julio 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $257 (Delta) |
One-way from | $112 (Kiwi.com) |
Popular in | July |
Cheapest in | January |
Average price | $486 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 1, 2026.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
MolineCharlotte
MLI - CLT
MLICLT
Moline Quad-City
mar. 8/25
6:00 am-11:03 am
1 stop4h 03m
Charlotte Douglas
lun. 8/31
11:50 am-4:25 pm
1 stop5h 35m
$257
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
mié. 7/22
5:50 am-1:00 pm
1 stop6h 10m
Myrtle Beach Intl
mié. 8/5
7:02 pm-10:23 pm
1 stop4h 21m
$285
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
sáb. 9/5
4:11 pm-11:57 pm
1 stop6h 46m
Charlotte Douglas
mar. 9/8
6:20 am-10:17 am
1 stop4h 57m
$287
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
mar. 9/1
7:15 am-7:10 pm
2 stops10h 55m
Myrtle Beach Intl
mié. 9/9
11:00 am-9:00 pm
2 stops11h 00m
$317
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
sáb. 11/7
11:27 am-5:14 pm
1 stop4h 47m
Charleston
mar. 11/10
9:30 am-1:27 pm
1 stop4h 57m
$317
Cedar RapidsCharleston
CID - CHS
CIDCHS
Cedar Rapids
mié. 8/5
6:30 am-2:27 pm
2 stops6h 57m
Charleston
mar. 8/11
10:19 am-9:19 pm
2 stops12h 00m
$319
OmahaCharlotte
OMA - CLT
OMACLT
Omaha Eppley Airfield
mar. 8/18
3:05 pm-9:10 pm
1 stop5h 05m
Charlotte Douglas
mié. 8/19
12:35 pm-7:20 pm
1 stop7h 45m
$321
OmahaCharlotte
OMA - CLT
OMACLT
Omaha Eppley Airfield
lun. 9/28
2:15 pm-9:50 pm
1 stop6h 35m
Charlotte Douglas
mié. 9/30
8:05 am-11:40 am
1 stop4h 35m
$323
Cedar RapidsCharleston
CID - CHS
CIDCHS
Cedar Rapids
vie. 10/16
5:45 am-11:26 am
1 stop4h 41m
Charleston
mié. 10/21
5:55 pm-9:51 pm
1 stop4h 56m
$324
Cedar RapidsCharleston
CID - CHS
CIDCHS
Cedar Rapids
sáb. 7/18
5:45 am-1:43 pm
1 stop6h 58m
Charleston
sáb. 7/25
5:00 pm-10:03 pm
1 stop6h 03m
$324
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
CID-CLT
MLI-CLT
DSM-CLT
OMA-CLT
DSM-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to South Carolina
USIA-USSC
CID-CLT
MLI-CLT
DSM-CLT
OMA-CLT
What is the cheapest month to book a flight from Iowa to South Carolina?
Currently, June is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $134). Flying from Iowa to South Carolina in March is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Iowa to South Carolina?
How far ahead should I book a flight from Iowa to South Carolina?
The best time to book flights from Iowa to South Carolina is 20 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated julio 1, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Food
7.0
Overall
7.9
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Crew
8.6
Food
7.0
Overall
7.9
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Crew
8.6
Food
7.0
Overall
7.9
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Crew
8.6
Food
7.0
Overall
7.9
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Comfort
8.0
Crew
8.6
Food
7.0
Overall
7.9
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Return Flight Options
Top destinations
Alternative routes for Iowa to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to South Carolina by cabin class
Find flights from Iowa to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and South Carolina flights
Browse other Iowa and South Carolina flight options. Last updated on julio 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Iowa after your stay in South Carolina
Iowa to South Carolina flights
Consider these flights traveling from Iowa to South Carolina.
Top 4 airlines flying from Iowa to South Carolina
Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$242 | Average$421 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$243 | Average$425 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$460 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$272 | Average$406 | FlexibilityNo cancel fee | On-time63% |