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South Carolina

$86+ Cheap flights from Iowa to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/4. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Cheap flight deals from Iowa to South Carolina

Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$137
(Mytrip)

One-way from

$86
(Kiwi.com)

Popular in

June

Cheapest in

August

Average price

$467
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
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From Iowa to South Carolina
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One-way flight from Iowa to South Carolina
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Highest demand for flights based on searches. 7% potential increase in price ($30 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Iowa to South Carolina

Cheapest flights from Iowa to South Carolina
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Mytrip deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:24 pmOMA - CLT
1 stop25h 25mFrontier
Thu 12/115:44 pmCLT - OMA
1 stop20h 47mFrontier
Deal found 11/4$137
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/59:00 amDSM - CLT
1 stop11h 38mMultiple Airlines
Sun 12/75:44 pmCLT - DSM
1 stop26h 19mMultiple Airlines
Deal found 11/4$227
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/15:42 pmCID - CLT
1 stop15h 08mMultiple Airlines
Fri 12/58:55 amCLT - CID
1 stop9h 12mMultiple Airlines
Deal found 11/5$229
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/18:08 pmCID - CLT
1 stop19h 42mMultiple Airlines
Thu 12/42:58 pmCLT - CID
1 stop27h 09mMultiple Airlines
Deal found 11/4$231
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:56 pmDSM - CHS
1 stop28h 58mMultiple Airlines
Thu 12/1111:55 amCHS - DSM
1 stop26h 00mMultiple Airlines
Deal found 11/5$234
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/172:40 pmCID - CLT
1 stop21h 52mMultiple Airlines
Thu 11/203:35 pmCLT - CID
2 stops27h 08mMultiple Airlines
Deal found 11/4$242
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:24 pmOMA - CLT
1 stop25h 25mFrontier
Wed 12/1010:45 amCLT - OMA
2 stops27h 46mFrontier
Deal found 11/5$245
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:57 pmCID - CLT
1 stop14h 42mMultiple Airlines
Sun 12/1410:33 pmCLT - CID
1 stop21h 14mMultiple Airlines
Deal found 11/5$246
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:57 pmCID - CLT
1 stop14h 42mMultiple Airlines
Mon 12/158:54 amCLT - CID
1 stop9h 13mMultiple Airlines
Deal found 11/5$248
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:50 amCID - CHS
1 stop4h 55mDelta
Sat 12/65:00 pmCHS - CID
1 stop6h 19mDelta
Deal found 11/4$249
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:46 pmDSM - CAE
1 stop4h 40mUnited Airlines
Tue 1/68:00 amCAE - DSM
1 stop7h 33mUnited Airlines
Deal found 11/3$249
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/66:25 amCID - SAV
1 stop6h 57mDelta
Sat 12/135:27 pmSAV - CID
1 stop5h 52mDelta
Deal found 11/5$249

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.

Fly from

Iowa

Fly to

South Carolina

Route

Depart

Return

Price

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 12/5

8:00 am-7:57 am

2 stops22h 57m

Charlotte Douglas

Sun 12/7

5:44 pm-7:03 pm

1 stop26h 19m

$233

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Thu 12/4

2:56 pm-8:54 pm

1 stop28h 58m

Charleston

Thu 12/11

11:55 am-12:55 pm

1 stop26h 00m

$234

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Tue 12/2

5:50 am-11:45 am

1 stop4h 55m

Charleston

Sat 12/6

5:00 pm-10:19 pm

1 stop6h 19m

$249

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Wed 2/4

6:35 am-2:02 pm

1 stop6h 27m

Charleston

Sun 2/8

6:05 am-10:47 am

1 stop5h 42m

$249

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Fri 1/16

6:25 am-11:39 am

1 stop4h 14m

Charleston

Sun 1/25

5:41 pm-11:05 pm

1 stop6h 24m

$249

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Fri 1/16

6:35 am-2:02 pm

1 stop6h 27m

Charleston

Fri 1/23

1:13 pm-7:10 pm

1 stop6h 57m

$249

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Sat 2/21

1:33 pm-10:28 pm

1 stop7h 55m

Charleston

Tue 2/24

7:40 pm-11:00 pm

1 stop4h 20m

$249

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Sat 12/6

5:50 am-11:24 am

1 stop4h 34m

Savannah/Hilton Head

Sat 12/13

5:27 pm-10:19 pm

1 stop5h 52m

$249

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Mon 11/24

8:00 am-1:55 pm

1 stop4h 55m

Charleston

Tue 12/2

4:38 pm-9:19 pm

1 stop5h 41m

$249

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Fri 12/12

6:25 am-2:22 pm

1 stop6h 57m

Savannah/Hilton Head

Sun 12/14

7:10 pm-10:19 pm

1 stop4h 09m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Showing 1-10 of 60 results
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Best time to book a flight from Iowa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to South Carolina

What is the cheapest month to book a flight from Iowa to South Carolina?

Currently, May is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $166). Flying from Iowa to South Carolina in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to SC?

Find hourly flight availability from Iowa to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

One of the essential ways to save on airfare from Iowa to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 11% on airfare.

What is the cheapest day to fly from Iowa to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Iowa to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Iowa to South Carolina flight should consider departing on Monday afternoons when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 6, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,240 reviews

Overall

8.0

Comfort

8.0

Food

7.0

Entertainment

7.5

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,240 reviews
Southwest
8.0
Very good
4,240 reviews

Overall

8.0

Comfort

8.0

Food

7.0

Entertainment

7.5

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
8,004 reviews
Southwest
8.0
Very good
4,240 reviews

Overall

8.0

Comfort

8.0

Food

7.0

Entertainment

7.5

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
9,003 reviews
Southwest
8.0
Very good
4,240 reviews

Overall

8.0

Comfort

8.0

Food

7.0

Entertainment

7.5

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,042 reviews
Southwest
8.0
Very good
4,240 reviews

Overall

8.0

Comfort

8.0

Food

7.0

Entertainment

7.5

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to South Carolina?

    Airlines like Delta, United Airlines, and American Airlines fly from Iowa to South Carolina in about 4h 14m. The time it takes to get you to your destination can typically vary by up to 2h 13m. The distance between Iowa and South Carolina is about 890 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Iowa to South Carolina one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $86. However, be on the lookout for offers from United Airlines and American Airlines, as they are both options that can get you from Iowa to South Carolina for a low price.

  • Can I find deals for flights from Iowa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Iowa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to South Carolina.

  • Can I find deals for business class flights from Iowa to South Carolina?

    Yes. Cheapflights offers flight deals from Iowa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $166). Flying from Iowa to South Carolina in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Iowa to South Carolina

Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$199Average$362FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$235Average$416FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$399FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$272Average$404FlexibilityNo cancel feeOn-time63%

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