$99+ Cheap flights from Iowa to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/29. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Jun 1 — Jun 81
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to South Carolina
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Cheapest flights from Iowa to South CarolinaExplore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 2, 2026.
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:45 pm
CID
- CLT
1 stop18h 26m
Multiple Airlines
Thu 5/149:07 pm
CLT
- CID
1 stop21h 48m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:11 pm
CID
- CLT
1 stop16h 23m
Multiple Airlines
Sun 5/319:07 pm
CLT
- CID
1 stop21h 14m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$186
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:45 pm
CID
- CLT
1 stop15h 49m
Multiple Airlines
Mon 5/186:00 am
CLT
- CID
1 stop12h 55m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:45 am
DSM
- CLT
1 stop11h 17m
Multiple Airlines
Sun 5/177:58 pm
CLT
- DSM
1 stop14h 35m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/205:55 pm
CID
- CLT
1 stop15h 45m
Multiple Airlines
Mon 7/275:45 am
CLT
- CID
1 stop12h 20m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:11 pm
CID
- MYR
1 stop25h 25m
Multiple Airlines
Fri 6/56:00 am
MYR
- CID
1 stop12h 09m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$234
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:11 pm
CID
- CLT
1 stop16h 23m
Multiple Airlines
Mon 6/16:00 am
CLT
- CID
1 stop12h 21m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:45 pm
CID
- CLT
1 stop16h 20m
Multiple Airlines
Sun 5/176:41 pm
CLT
- CID
1 stop24h 14m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:41 pm
DSM
- CLT
1 stop16h 22m
Multiple Airlines
Fri 5/2912:29 pm
CLT
- DSM
1 stop11h 55m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/13:57 pm
DSM
- CLT
1 stop19h 08m
Multiple Airlines
Wed 6/33:16 pm
CLT
- DSM
2 stops31h 11m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CLT
2 stops41h 53m
Multiple Airlines
Thu 6/41:00 pm
CLT
- DSM
1 stop9h 27m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:04 pm
CID
- CLT
1 stop17h 10m
Multiple Airlines
Thu 6/186:43 pm
CLT
- CID
1 stop23h 31m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$254
Best flights from Iowa to South CarolinaDiscover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 2, 2026.
Discover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 2, 2026.
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:54 am
CID
- SAV
1 stop5h 22m
United Airlines
Tue 6/163:14 pm
SAV
- CID
1 stop7h 17m
United Airlines
Deal found 4/29![United Airlines logo]()
$261
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1512:40 pm
CID
- SAV
1 stop5h 18m
American Airlines
Tue 7/212:59 pm
SAV
- CID
2 stops10h 15m
American Airlines
Deal found 4/27![American Airlines logo]()
$266
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/25:45 am
CID
- SAV
1 stop4h 35m
Delta
Tue 9/85:35 pm
SAV
- CID
1 stop5h 15m
Delta
Deal found 4/27![Delta logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:11 pm
CID
- MYR
2 stops18h 26m
Multiple Airlines
Fri 6/56:00 am
MYR
- CID
1 stop12h 09m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$280
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/193:35 pm
OMA
- CHS
1 stop4h 30m
Southwest
Tue 5/263:40 pm
CHS
- OMA
1 stop7h 30m
Southwest
Deal found 4/27![Southwest logo]()
$351
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/252:34 pm
CID
- SAV
1 stop5h 58m
United Airlines
Sat 8/299:50 am
SAV
- CID
2 stops10h 22m
United Airlines
Deal found 5/1![United Airlines logo]()
$266
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:00 am
CID
- MYR
2 stops10h 26m
American Airlines
Wed 7/14:17 pm
MYR
- CID
2 stops8h 34m
American Airlines
Deal found 4/27![American Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:39 pm
DSM
- MYR
1 stop4h 20m
Delta
Tue 6/1611:30 am
MYR
- DSM
1 stop6h 53m
Delta
Deal found 5/1![Delta logo]()
$335
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:25 am
CID
- MYR
1 stop6h 41m
United Airlines
Wed 6/33:08 pm
MYR
- CID
1 stop7h 23m
United Airlines
Deal found 4/29![United Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/105:00 am
CID
- MYR
1 stop5h 38m
American Airlines
Sat 8/158:28 pm
MYR
- CID
1 stop4h 30m
American Airlines
Deal found 4/29![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:45 am
CID
- MYR
1 stop5h 55m
Delta
Tue 5/194:07 pm
MYR
- CID
1 stop6h 07m
Delta
Deal found 4/29![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:50 am
OMA
- CLT
1 stop5h 05m
Southwest
Wed 8/2611:10 am
CLT
- OMA
1 stop4h 10m
Southwest
Deal found 4/28![Southwest logo]()
$377
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:25 am
CID
- MYR
1 stop6h 50m
United Airlines
Wed 8/1910:28 am
MYR
- CID
2 stops12h 01m
United Airlines
Deal found 4/27![United Airlines logo]()
$326
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:10 am
DSM
- MYR
2 stops8h 55m
Southwest
Sun 9/202:45 pm
MYR
- DSM
2 stops8h 50m
Southwest
Deal found 4/27![Southwest logo]()
$381
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/151:31 pm
CID
- MYR
2 stops7h 26m
American Airlines
Wed 8/195:15 pm
MYR
- CID
1 stop6h 38m
American Airlines
Deal found 5/1![American Airlines logo]()
$351
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/115:07 pm
MLI
- CLT
1 stop5h 51m
Delta
Tue 7/146:59 am
CLT
- MLI
1 stop4h 23m
Delta
Deal found 4/27![Delta logo]()
$353
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:25 am
CID
- MYR
1 stop6h 50m
United Airlines
Tue 8/2510:28 am
MYR
- CID
2 stops9h 44m
United Airlines
Deal found 4/29![United Airlines logo]()
$326
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:25 am
DSM
- CLT
2 stops10h 25m
Southwest
Tue 6/237:05 pm
CLT
- DSM
1 stop4h 40m
Southwest
Deal found 5/1![Southwest logo]()
$382
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:31 am
CID
- MYR
1 stop7h 11m
American Airlines
Wed 10/215:31 am
MYR
- CID
2 stops7h 37m
American Airlines
Deal found 4/27![American Airlines logo]()
$351
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/411:16 am
MLI
- CLT
1 stop6h 09m
Delta
Wed 8/55:30 am
CLT
- MLI
1 stop5h 52m
Delta
Deal found 5/1![Delta logo]()
$353
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/128:00 am
CID
- SAV
1 stop6h 13m
United Airlines
Sat 5/168:08 am
SAV
- CID
1 stop6h 50m
United Airlines
Deal found 4/27![United Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/14:20 pm
DSM
- CLT
1 stop4h 40m
Southwest
Wed 6/36:20 pm
CLT
- DSM
1 stop4h 50m
Southwest
Deal found 4/27![Southwest logo]()
$387
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:35 am
DSM
- MYR
1 stop4h 09m
Delta
Sat 7/47:00 am
MYR
- DSM
1 stop4h 45m
Delta
Deal found 4/27![Delta logo]()
$371
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:54 am
CID
- MYR
1 stop5h 18m
United Airlines
Mon 6/13:08 pm
MYR
- CID
1 stop7h 23m
United Airlines
Deal found 4/27![United Airlines logo]()
$340
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:00 am
DSM
- MYR
2 stops9h 32m
American Airlines
Sat 6/208:41 pm
MYR
- DSM
1 stop4h 29m
American Airlines
Deal found 5/1![American Airlines logo]()
$376
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/84:40 pm
DSM
- CLT
1 stop4h 10m
Southwest
Wed 6/107:05 pm
CLT
- DSM
1 stop4h 40m
Southwest
Deal found 4/30![Southwest logo]()
$387
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/292:34 pm
CID
- SAV
1 stop5h 58m
United Airlines
Tue 9/11:00 pm
SAV
- CID
1 stop7h 12m
United Airlines
Deal found 4/29![United Airlines logo]()
$341
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/256:33 pm
OMA
- SAV
1 stop4h 21m
Delta
Sun 6/283:53 pm
SAV
- OMA
1 stop6h 01m
Delta
Deal found 4/27![Delta logo]()
$377
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/23:10 pm
DSM
- CLT
1 stop4h 45m
Southwest
Thu 6/47:05 pm
CLT
- DSM
1 stop5h 25m
Southwest
Deal found 4/27![Southwest logo]()
$387
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:25 am
CID
- SAV
1 stop6h 46m
United Airlines
Wed 9/26:45 am
SAV
- CID
2 stops11h 30m
United Airlines
Deal found 4/30![United Airlines logo]()
$346
Last-minute flights from Iowa to South CarolinaDiscover last-minute flight deals from Iowa to South Carolina. Data last updated May 2, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to South Carolina. Data last updated May 2, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:45 pm
CID
- CLT
1 stop18h 26m
Multiple Airlines
Thu 5/149:07 pm
CLT
- CID
1 stop21h 48m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:48 pm
DSM
- CLT
2 stops18h 23m
Multiple Airlines
Wed 5/133:16 pm
CLT
- DSM
1 stop24h 59m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:45 am
DSM
- CLT
1 stop11h 17m
Multiple Airlines
Sun 5/177:58 pm
CLT
- DSM
1 stop14h 35m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:45 pm
CID
- CLT
1 stop15h 49m
Multiple Airlines
Mon 5/186:00 am
CLT
- CID
1 stop12h 55m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:45 pm
CID
- CLT
1 stop16h 20m
Multiple Airlines
Sun 5/176:41 pm
CLT
- CID
1 stop24h 14m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:45 pm
CID
- MYR
1 stop24h 51m
Multiple Airlines
Mon 5/186:00 am
MYR
- CID
1 stop12h 55m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:41 pm
DSM
- CLT
1 stop16h 22m
Multiple Airlines
Fri 5/2912:29 pm
CLT
- DSM
1 stop11h 55m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$245
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:00 am
CID
- MYR
2 stops8h 58m
American Airlines
Wed 6/36:06 pm
MYR
- CID
1 stop4h 57m
American Airlines
Deal found 4/29![American Airlines logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CLT
2 stops41h 53m
Multiple Airlines
Thu 6/41:00 pm
CLT
- DSM
1 stop9h 27m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:11 pm
CID
- CLT
1 stop16h 23m
Multiple Airlines
Sun 5/319:07 pm
CLT
- CID
1 stop21h 14m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$186
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:11 pm
CID
- MYR
1 stop25h 25m
Multiple Airlines
Fri 6/56:00 am
MYR
- CID
1 stop12h 09m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$234
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:11 pm
CID
- CLT
1 stop16h 23m
Multiple Airlines
Mon 6/16:00 am
CLT
- CID
1 stop12h 21m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$236
One-way flights from Iowa to South CarolinaSearch for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated May 2, 2026.
Search for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated May 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:11 pm
CID
- CLT
1 stop16h 23m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:45 pm
CID
- CLT
1 stop15h 49m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:44 pm
DSM
- CLT
1 stop16h 30m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/256:11 pm
CID
- CLT
1 stop19h 00m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/295:59 pm
CID
- CLT
1 stop28h 13m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:02 pm
DSM
- CLT
1 stop20h 50m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/295:45 pm
DSM
- CLT
1 stop17h 29m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$113
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/274:40 pm
DSM
- CLT
1 stop17h 00m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:45 pm
MLI
- CLT
1 stop24h 07m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$120
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:45 am
DSM
- CLT
1 stop14h 55m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CLT
2 stops41h 53m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$126
This CheapOair deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- CLT
1 stop27h 02m
Frontier
Deal found 5/1![Frontier logo]()
$127
Find flight deals from Iowa to South Carolina
Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated May 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $170 (Kiwi.com) |
One-way from | $99 (Kiwi.com) |
Popular in | June |
Cheapest in | January |
Average price | $386 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 2, 2026.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Cedar RapidsSavannah
CID - SAV
CIDSAV
Cedar Rapids
Tue 6/9
7:54 am-2:16 pm
1 stop5h 22m
Savannah/Hilton Head
Tue 6/16
3:14 pm-9:31 pm
1 stop7h 17m
$261
Cedar RapidsSavannah
CID - SAV
CIDSAV
Cedar Rapids
Wed 7/15
12:40 pm-6:58 pm
1 stop5h 18m
Savannah/Hilton Head
Tue 7/21
2:59 pm-12:14 am
2 stops10h 15m
$266
Cedar RapidsSavannah
CID - SAV
CIDSAV
Cedar Rapids
Tue 8/25
2:34 pm-9:32 pm
1 stop5h 58m
Savannah/Hilton Head
Sat 8/29
9:50 am-7:12 pm
2 stops10h 22m
$266
Cedar RapidsSavannah
CID - SAV
CIDSAV
Cedar Rapids
Wed 9/2
5:45 am-11:20 am
1 stop4h 35m
Savannah/Hilton Head
Tue 9/8
5:35 pm-9:50 pm
1 stop5h 15m
$276
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Fri 5/29
6:11 pm-1:37 pm
2 stops18h 26m
Myrtle Beach Intl
Fri 6/5
6:00 am-5:09 pm
1 stop12h 09m
$280
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Tue 6/23
6:00 am-5:26 pm
2 stops10h 26m
Myrtle Beach Intl
Wed 7/1
4:17 pm-11:51 pm
2 stops8h 34m
$314
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Wed 5/27
6:25 am-2:06 pm
1 stop6h 41m
Myrtle Beach Intl
Wed 6/3
3:08 pm-9:31 pm
1 stop7h 23m
$314
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Mon 8/10
5:00 am-11:38 am
1 stop5h 38m
Myrtle Beach Intl
Sat 8/15
8:28 pm-11:58 pm
1 stop4h 30m
$319
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Fri 8/14
6:25 am-2:15 pm
1 stop6h 50m
Myrtle Beach Intl
Wed 8/19
10:28 am-9:29 pm
2 stops12h 01m
$326
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Thu 8/20
6:25 am-2:15 pm
1 stop6h 50m
Myrtle Beach Intl
Tue 8/25
10:28 am-7:12 pm
2 stops9h 44m
$326
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
CID-SAV
CID-MYR
OMA-CHS
DSM-MYR
OMA-CLT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to South Carolina
USIA-USSC
CID-SAV
CID-MYR
OMA-CHS
DSM-MYR
How far ahead should I book a flight from Iowa to South Carolina?
The best time to book flights from Iowa to South Carolina is 60 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Iowa to South Carolina?
Currently, November is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $118). Flying from Iowa to South Carolina in March is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Iowa to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated May 2, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.5
Overall
8.0
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Entertainment
7.5
Overall
8.0
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Entertainment
7.5
Overall
8.0
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Entertainment
7.5
Overall
8.0
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Entertainment
7.5
Overall
8.0
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Iowa to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to South Carolina by cabin class
Find flights from Iowa to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and South Carolina flights
Browse other Iowa and South Carolina flight options. Last updated on May 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Iowa after your stay in South Carolina
Iowa to South Carolina flights
Consider these flights traveling from Iowa to South Carolina.
Top 4 airlines flying from Iowa to South Carolina
Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$236 | Average$410 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$242 | Average$407 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$448 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$272 | Average$404 | FlexibilityNo cancel fee | On-time63% |