$123+ Cheap flights from Iowa to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Aug 28 — Sep 41
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to South Carolina
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Cheapest flights from Iowa to South CarolinaExplore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2026.
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/113:54 pm
DSM
- MYR
1 stop15h 04m
Multiple Airlines
Thu 10/158:35 am
MYR
- DSM
1 stop7h 07m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$223
This CheapOair deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:29 am
DSM
- CLT
1 stop6h 30m
Frontier
Thu 10/17:54 pm
CLT
- DSM
1 stop24h 39m
Frontier
Deal found 7/26![Frontier logo]()
$257
This CheapOair deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:29 am
DSM
- CLT
1 stop6h 30m
Frontier
Sun 9/277:54 pm
CLT
- DSM
1 stop24h 39m
Frontier
Deal found 7/27![Frontier logo]()
$264
This CheapOair deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/1311:29 am
DSM
- CLT
1 stop6h 30m
Frontier
Thu 9/177:54 pm
CLT
- DSM
1 stop24h 39m
Frontier
Deal found 7/25![Frontier logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/131:58 pm
DSM
- CHS
2 stops41h 40m
Multiple Airlines
Fri 9/183:59 pm
CHS
- DSM
1 stop7h 09m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$286
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:00 am
CID
- MYR
1 stop7h 53m
United Airlines
Tue 8/256:21 pm
MYR
- CID
1 stop5h 21m
United Airlines
Deal found 7/24![United Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:10 am
DSM
- MYR
2 stops22h 48m
Multiple Airlines
Sun 10/118:35 am
MYR
- DSM
1 stop7h 07m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/210:30 am
OMA
- CHS
2 stops25h 01m
Multiple Airlines
Thu 11/510:05 pm
CHS
- OMA
1 stop13h 25m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$310
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:00 am
CID
- MYR
1 stop5h 31m
American Airlines
Wed 10/218:14 pm
MYR
- CID
1 stop4h 44m
American Airlines
Deal found 7/26![American Airlines logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1410:05 am
DSM
- CHS
2 stops35h 05m
Multiple Airlines
Fri 9/183:59 pm
CHS
- DSM
1 stop7h 09m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/61:58 pm
DSM
- MYR
2 stops43h 07m
Multiple Airlines
Thu 9/109:37 am
MYR
- DSM
1 stop11h 20m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/61:58 pm
DSM
- CHS
2 stops41h 40m
Multiple Airlines
Fri 9/113:59 pm
CHS
- DSM
1 stop7h 09m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$319
Best flights from Iowa to South CarolinaDiscover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2026.
Discover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2026.
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:00 am
CID
- MYR
1 stop7h 53m
United Airlines
Tue 8/256:21 pm
MYR
- CID
1 stop5h 21m
United Airlines
Deal found 7/24![United Airlines logo]()
$295
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/225:00 pm
MLI
- MYR
1 stop5h 35m
Delta
Mon 1/256:00 am
MYR
- MLI
1 stop5h 26m
Delta
Deal found 7/28![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:50 am
DSM
- CLT
1 stop4h 05m
Southwest
Tue 10/136:55 pm
CLT
- DSM
1 stop4h 00m
Southwest
Deal found 7/28![Southwest logo]()
$321
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:30 pm
DSM
- CHS
1 stop6h 36m
American Airlines
Sat 10/37:18 am
CHS
- DSM
1 stop7h 41m
American Airlines
Deal found 7/24![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:00 am
CID
- MYR
1 stop7h 53m
United Airlines
Mon 8/246:21 pm
MYR
- CID
1 stop5h 21m
United Airlines
Deal found 7/24![United Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:10 am
DSM
- CLT
1 stop4h 25m
Southwest
Mon 11/27:00 pm
CLT
- DSM
1 stop5h 00m
Southwest
Deal found 7/25![Southwest logo]()
$321
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:27 am
DSM
- CHS
1 stop4h 57m
Delta
Tue 11/106:45 am
CHS
- DSM
1 stop4h 58m
Delta
Deal found 7/26![Delta logo]()
$325
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/2211:21 am
MLI
- MYR
2 stops8h 33m
American Airlines
Mon 1/253:30 pm
MYR
- MLI
2 stops9h 41m
American Airlines
Deal found 7/27![American Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:35 am
OMA
- CLT
1 stop4h 35m
Southwest
Wed 8/1911:10 am
CLT
- OMA
1 stop4h 10m
Southwest
Deal found 7/25![Southwest logo]()
$321
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/54:11 pm
DSM
- CHS
1 stop6h 48m
Delta
Wed 9/96:05 am
CHS
- DSM
1 stop5h 41m
Delta
Deal found 7/26![Delta logo]()
$325
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:00 am
DSM
- MYR
1 stop5h 53m
United Airlines
Wed 9/910:10 am
MYR
- DSM
2 stops8h 18m
United Airlines
Deal found 7/27![United Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/912:19 pm
OMA
- CHS
1 stop5h 25m
American Airlines
Sat 9/127:18 am
CHS
- OMA
1 stop5h 24m
American Airlines
Deal found 7/29![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:00 am
CID
- MYR
1 stop6h 33m
Delta
Tue 8/2511:33 am
MYR
- CID
2 stops11h 50m
Delta
Deal found 7/24![Delta logo]()
$325
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:30 am
DSM
- CLT
1 stop5h 50m
Southwest
Thu 8/2711:50 am
CLT
- DSM
2 stops10h 25m
Southwest
Deal found 7/27![Southwest logo]()
$326
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:55 am
OMA
- CHS
1 stop5h 03m
United Airlines
Wed 12/166:05 am
CHS
- OMA
1 stop5h 28m
United Airlines
Deal found 7/26![United Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/285:15 pm
OMA
- CLT
Nonstop2h 38m
American Airlines
Tue 9/12:56 pm
CLT
- OMA
Nonstop2h 34m
American Airlines
Deal found 7/24![American Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:15 am
DSM
- CLT
2 stops10h 45m
Southwest
Thu 8/208:10 am
CLT
- DSM
1 stop4h 15m
Southwest
Deal found 7/28![Southwest logo]()
$326
This Delta deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/105:00 pm
MLI
- MYR
1 stop5h 35m
Delta
Tue 12/1510:55 am
MYR
- MLI
1 stop6h 27m
Delta
Deal found 7/24![Delta logo]()
$329
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:02 am
OMA
- MYR
1 stop7h 51m
United Airlines
Wed 9/210:08 am
MYR
- OMA
2 stops10h 56m
United Airlines
Deal found 7/28![United Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/21:30 pm
DSM
- MYR
1 stop6h 38m
American Airlines
Sat 10/108:14 pm
MYR
- DSM
1 stop4h 44m
American Airlines
Deal found 7/27![American Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:09 pm
MLI
- MYR
1 stop5h 19m
Delta
Fri 10/96:00 am
MYR
- MLI
1 stop5h 21m
Delta
Deal found 7/24![Delta logo]()
$329
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:20 am
DSM
- CLT
2 stops10h 05m
Southwest
Thu 9/241:05 pm
CLT
- DSM
2 stops10h 05m
Southwest
Deal found 7/25![Southwest logo]()
$331
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/63:11 pm
OMA
- CHS
1 stop5h 23m
United Airlines
Fri 9/112:54 pm
CHS
- OMA
2 stops9h 10m
United Airlines
Deal found 7/27![United Airlines logo]()
$348
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:30 am
OMA
- CLT
1 stop4h 35m
Southwest
Sat 10/104:10 pm
CLT
- OMA
1 stop5h 20m
Southwest
Deal found 7/28![Southwest logo]()
$332
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:07 am
CID
- MYR
1 stop4h 19m
American Airlines
Sun 9/136:15 pm
MYR
- CID
1 stop5h 04m
American Airlines
Deal found 7/25![American Airlines logo]()
$370
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:00 am
CID
- MYR
1 stop6h 33m
Delta
Fri 9/411:33 am
MYR
- CID
2 stops10h 50m
Delta
Deal found 7/28![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/143:22 pm
DSM
- CHS
1 stop6h 47m
United Airlines
Fri 9/188:30 am
CHS
- DSM
1 stop8h 49m
United Airlines
Deal found 7/25![United Airlines logo]()
$358
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:05 am
DSM
- MYR
2 stops10h 20m
Southwest
Sat 11/710:35 am
MYR
- DSM
2 stops11h 00m
Southwest
Deal found 7/24![Southwest logo]()
$335
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:09 pm
DSM
- MYR
2 stops8h 44m
American Airlines
Mon 9/147:19 pm
MYR
- DSM
1 stop5h 22m
American Airlines
Deal found 7/28![American Airlines logo]()
$371
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/54:00 pm
OMA
- CHS
1 stop6h 59m
Delta
Wed 9/95:34 pm
CHS
- OMA
1 stop6h 18m
Delta
Deal found 7/28![Delta logo]()
$339
Last-minute flights from Iowa to South CarolinaDiscover last-minute flight deals from Iowa to South Carolina. Data last updated July 29, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to South Carolina. Data last updated July 29, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/291:45 pm
OMA
- CLT
Nonstop2h 40m
American Airlines
Sat 8/110:41 pm
CLT
- OMA
Nonstop2h 38m
American Airlines
Deal found 7/28![American Airlines logo]()
$323
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/124:05 pm
MLI
- MYR
1 stop5h 33m
American Airlines
Tue 8/185:15 pm
MYR
- MLI
1 stop4h 58m
American Airlines
Deal found 7/27![American Airlines logo]()
$334
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:35 am
OMA
- CLT
1 stop4h 35m
Southwest
Wed 8/1911:10 am
CLT
- OMA
1 stop4h 10m
Southwest
Deal found 7/25![Southwest logo]()
$321
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:00 am
CID
- MYR
1 stop7h 53m
United Airlines
Mon 8/246:21 pm
MYR
- CID
1 stop5h 21m
United Airlines
Deal found 7/24![United Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/201:08 pm
DSM
- MYR
1 stop6h 51m
American Airlines
Mon 8/246:04 pm
MYR
- DSM
1 stop6h 40m
American Airlines
Deal found 7/27![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:00 am
CID
- MYR
1 stop7h 53m
United Airlines
Tue 8/256:21 pm
MYR
- CID
1 stop5h 21m
United Airlines
Deal found 7/24![United Airlines logo]()
$295
This Delta deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:00 am
CID
- MYR
1 stop6h 33m
Delta
Tue 8/2511:33 am
MYR
- CID
2 stops11h 50m
Delta
Deal found 7/24![Delta logo]()
$325
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/241:08 pm
DSM
- CHS
1 stop4h 40m
American Airlines
Thu 9/36:11 am
CHS
- DSM
1 stop7h 13m
American Airlines
Deal found 7/26![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:06 am
CID
- MYR
1 stop5h 47m
United Airlines
Sat 8/2910:23 am
MYR
- CID
2 stops11h 56m
United Airlines
Deal found 7/27![United Airlines logo]()
$338
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/284:05 pm
MLI
- MYR
1 stop5h 33m
American Airlines
Sun 8/306:32 pm
MYR
- MLI
1 stop5h 09m
American Airlines
Deal found 7/28![American Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:30 am
DSM
- CLT
1 stop5h 50m
Southwest
Mon 8/316:30 pm
CLT
- DSM
1 stop4h 40m
Southwest
Deal found 7/26![Southwest logo]()
$321
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:20 am
OMA
- MYR
1 stop8h 17m
American Airlines
Thu 9/37:33 pm
MYR
- OMA
1 stop5h 05m
American Airlines
Deal found 7/26![American Airlines logo]()
$339
One-way flights from Iowa to South CarolinaSearch for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated July 29, 2026.
Search for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated July 29, 2026.
This Frontier deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:29 am
DSM
- CLT
1 stop6h 30m
Frontier
Deal found 7/26![Frontier logo]()
$123
This Frontier deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2711:29 am
DSM
- CLT
1 stop6h 30m
Frontier
Deal found 7/26![Frontier logo]()
$131
This Trip.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/78:00 pm
OMA
- CLT
1 stop24h 19m
Frontier
Deal found 7/27![Frontier logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/271:58 pm
DSM
- CHS
2 stops41h 40m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$142
This CheapOair deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:19 pm
DSM
- CLT
1 stop25h 07m
Frontier
Deal found 7/29![Frontier logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/258:00 am
DSM
- CLT
1 stop23h 27m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/301:55 pm
DSM
- CLT
1 stop17h 56m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$154
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:10 am
DSM
- MYR
2 stops22h 48m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/28:44 am
DSM
- MYR
1 stop26h 00m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$156
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:07 pm
DSM
- CHS
1 stop23h 07m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:43 am
DSM
- CLT
1 stop22h 44m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$159
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/252:40 pm
DSM
- CLT
1 stop5h 30m
Southwest
Deal found 7/27![Southwest logo]()
$161
Find flight deals from Iowa to South Carolina
Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated July 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $223 (Kiwi.com) |
One-way from | $123 (Frontier) |
Popular in | October |
Cheapest in | January |
Average price | $486 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Fri 8/21
6:00 am-2:53 pm
1 stop7h 53m
Myrtle Beach Intl
Tue 8/25
6:21 pm-10:42 pm
1 stop5h 21m
$295
MolineMyrtle Beach
MLI - MYR
MLIMYR
Moline Quad-City
Fri 1/22
5:00 pm-11:35 pm
1 stop5h 35m
Myrtle Beach Intl
Mon 1/25
6:00 am-10:26 am
1 stop5h 26m
$319
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Thu 8/20
6:00 am-2:53 pm
1 stop7h 53m
Myrtle Beach Intl
Mon 8/24
6:21 pm-10:42 pm
1 stop5h 21m
$319
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
Sat 10/10
5:50 am-10:55 am
1 stop4h 05m
Charlotte Douglas
Tue 10/13
6:55 pm-9:55 pm
1 stop4h 00m
$321
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
Mon 10/19
5:10 am-10:35 am
1 stop4h 25m
Charlotte Douglas
Mon 11/2
7:00 pm-11:00 pm
1 stop5h 00m
$321
OmahaCharlotte
OMA - CLT
OMACLT
Omaha Eppley Airfield
Mon 8/17
5:35 am-11:10 am
1 stop4h 35m
Charlotte Douglas
Wed 8/19
11:10 am-2:20 pm
1 stop4h 10m
$321
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Wed 9/30
1:30 pm-9:06 pm
1 stop6h 36m
Charleston
Sat 10/3
7:18 am-1:59 pm
1 stop7h 41m
$325
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Sat 11/7
11:27 am-5:24 pm
1 stop4h 57m
Charleston
Tue 11/10
6:45 am-10:43 am
1 stop4h 58m
$325
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Sat 9/5
4:11 pm-11:59 pm
1 stop6h 48m
Charleston
Wed 9/9
6:05 am-10:46 am
1 stop5h 41m
$325
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Fri 8/21
6:00 am-1:33 pm
1 stop6h 33m
Myrtle Beach Intl
Tue 8/25
11:33 am-10:23 pm
2 stops11h 50m
$325
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
CID-MYR
MLI-MYR
OMA-CLT
DSM-CLT
DSM-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to South Carolina
USIA-USSC
CID-MYR
MLI-MYR
OMA-CLT
DSM-CLT
What is the cheapest month to book a flight from Iowa to South Carolina?
Currently, February is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $317). Flying from Iowa to South Carolina in March is currently the most expensive (average of $473). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How far ahead should I book a flight from Iowa to South Carolina?
The best time to book flights from Iowa to South Carolina is 85 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated July 29, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Iowa to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to South Carolina by cabin class
Find flights from Iowa to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and South Carolina flights
Browse other Iowa and South Carolina flight options. Last updated on July 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Iowa after your stay in South Carolina
Iowa to South Carolina flights
Consider these flights traveling from Iowa to South Carolina.
Top 4 airlines flying from Iowa to South Carolina
Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$158 | Average$427 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$448 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$427 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$344 | Average$412 | FlexibilityNo cancel fee | On-time63% |