$111+ Cheap flights from Iowa to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Sep 26 — Oct 31
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to South Carolina
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Cheapest flights from Iowa to South CarolinaExplore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 27, 2026.
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 27, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/113:54 pm -
1 stop15h 04m
Thu 10/159:32 am -
1 stop6h 10m
Deal found 8/23![Multiple Airlines logo]()
$256
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/141:37 pm -
1 stop4h 53m
Wed 10/218:01 pm -
1 stop4h 57m
Deal found 8/24![American Airlines logo]()
$271
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:55 am -
1 stop5h 35m
Wed 9/304:00 pm -
1 stop7h 47m
Deal found 8/23![United Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:29 pm -
1 stop22h 30m
Sun 9/207:54 pm -
1 stop23h 40m
Deal found 8/23![Frontier logo]()
$272
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:23 am -
1 stop7h 01m
Wed 10/1411:19 am -
2 stops11h 18m
Deal found 8/24![Delta logo]()
$276
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:00 am -
2 stops9h 25m
Sat 11/146:00 am -
2 stops11h 08m
Deal found 8/27![Delta logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:10 am -
1 stop7h 33m
Tue 10/69:40 pm -
2 stops34h 58m
Deal found 8/26![Multiple Airlines logo]()
$287
This CheapOair deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:29 am -
1 stop6h 30m
Sun 9/277:54 pm -
1 stop24h 39m
Deal found 8/24![Frontier logo]()
$289
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:23 am -
1 stop7h 01m
Fri 10/164:46 pm -
1 stop6h 10m
Deal found 8/25![Delta logo]()
$295
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:09 am -
1 stop4h 14m
Wed 11/115:03 pm -
1 stop7h 23m
Deal found 8/27![American Airlines logo]()
$297
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:55 am -
2 stops10h 40m
Mon 9/144:23 pm -
1 stop7h 19m
Deal found 8/24![United Airlines logo]()
$300
This Southwest deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:50 am -
2 stops10h 25m
Tue 10/207:50 am -
1 stop4h 40m
Deal found 8/27![Southwest logo]()
$302
Best flights from Iowa to South CarolinaDiscover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 27, 2026.
Discover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 27, 2026.
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/141:37 pm -
1 stop4h 53m
Wed 10/218:01 pm -
1 stop4h 57m
Deal found 8/23![American Airlines logo]()
$271
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:15 am -
1 stop5h 20m
Sat 11/147:12 am -
2 stops9h 56m
Deal found 8/27![Delta logo]()
$276
This Southwest deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:50 am -
1 stop4h 10m
Tue 10/277:50 am -
1 stop4h 40m
Deal found 8/27![Southwest logo]()
$297
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:45 am -
1 stop8h 17m
Tue 10/205:00 pm -
1 stop7h 35m
Deal found 8/27![United Airlines logo]()
$324
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:23 am -
1 stop7h 01m
Wed 10/1411:19 am -
2 stops11h 18m
Deal found 8/24![Delta logo]()
$276
This Southwest deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:20 am -
2 stops6h 35m
Wed 11/113:25 pm -
2 stops7h 35m
Deal found 8/23![Southwest logo]()
$307
This Delta deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:40 am -
1 stop4h 54m
Wed 9/305:30 am -
2 stops6h 52m
Deal found 8/23![Delta logo]()
$300
This Southwest deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:50 am -
2 stops10h 25m
Tue 10/202:10 pm -
2 stops8h 50m
Deal found 8/27![Southwest logo]()
$307
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:11 pm -
1 stop6h 54m
Thu 11/127:00 am -
1 stop4h 35m
Deal found 8/23![American Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:00 am -
1 stop7h 20m
Tue 10/206:45 am -
1 stop4h 39m
Deal found 8/26![United Airlines logo]()
$343
This Southwest deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:35 am -
2 stops12h 50m
Tue 10/207:50 am -
1 stop4h 40m
Deal found 8/26![Southwest logo]()
$308
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/203:04 pm -
1 stop6h 17m
Sat 10/243:00 pm -
2 stops8h 59m
Deal found 8/22![United Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/141:37 pm -
1 stop4h 53m
Mon 10/198:12 pm -
1 stop4h 38m
Deal found 8/23![American Airlines logo]()
$346
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:30 am -
1 stop5h 22m
Sat 11/146:00 am -
1 stop5h 51m
Deal found 8/22![Delta logo]()
$325
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:55 am -
2 stops10h 01m
Wed 9/306:45 am -
1 stop4h 39m
Deal found 8/22![United Airlines logo]()
$348
This Delta deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/74:07 pm -
1 stop4h 37m
Tue 11/103:22 pm -
1 stop6h 51m
Deal found 8/23![Delta logo]()
$325
This Southwest deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:20 am -
2 stops6h 35m
Thu 11/1210:45 am -
2 stops12h 15m
Deal found 8/23![Southwest logo]()
$344
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:29 am -
1 stop6h 33m
Fri 10/97:04 pm -
1 stop5h 54m
Deal found 8/26![American Airlines logo]()
$391
This Delta deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:07 pm -
1 stop6h 52m
Tue 10/274:20 pm -
1 stop7h 13m
Deal found 8/26![Delta logo]()
$325
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:30 am -
1 stop4h 40m
Sat 9/196:45 am -
2 stops12h 00m
Deal found 8/25![United Airlines logo]()
$360
This Southwest deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:35 am -
2 stops11h 00m
Wed 10/141:55 pm -
2 stops9h 00m
Deal found 8/23![Southwest logo]()
$355
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:00 am -
2 stops10h 11m
Wed 11/1811:27 am -
2 stops11h 08m
Deal found 8/24![United Airlines logo]()
$361
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:42 pm -
1 stop4h 15m
Tue 10/136:58 pm -
1 stop5h 08m
Deal found 8/22![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/275:34 pm -
1 stop5h 11m
Fri 10/21:56 pm -
2 stops11h 17m
Deal found 8/22![American Airlines logo]()
$418
This Southwest deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:05 am -
1 stop6h 20m
Mon 11/24:30 pm -
2 stops7h 25m
Deal found 8/25![Southwest logo]()
$358
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:32 am -
2 stops9h 23m
Sat 10/105:31 pm -
1 stop6h 07m
Deal found 8/23![United Airlines logo]()
$368
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/245:35 am -
1 stop6h 37m
Thu 12/3111:10 am -
1 stop7h 25m
Deal found 8/24![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/710:50 am -
2 stops7h 40m
Mon 11/97:25 pm -
1 stop5h 15m
Deal found 8/24![Southwest logo]()
$358
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/85:17 pm -
1 stop5h 40m
Sun 11/158:32 pm -
1 stop4h 33m
Deal found 8/22![American Airlines logo]()
$437
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/202:07 pm -
1 stop6h 58m
Sat 10/241:09 pm -
1 stop5h 02m
Deal found 8/22![Delta logo]()
$339
Last-minute flights from Iowa to South CarolinaDiscover last-minute flight deals from Iowa to South Carolina. Data last updated August 27, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to South Carolina. Data last updated August 27, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:18 pm -
1 stop25h 08m
Thu 9/107:54 pm -
1 stop23h 40m
Deal found 8/26![Frontier logo]()
$319
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:40 am -
1 stop4h 54m
Mon 9/146:36 pm -
1 stop4h 17m
Deal found 8/24![Delta logo]()
$295
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:55 am -
2 stops10h 40m
Mon 9/144:23 pm -
1 stop7h 19m
Deal found 8/24![United Airlines logo]()
$300
This CheapOair deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:29 pm -
1 stop22h 30m
Sun 9/137:54 pm -
1 stop23h 40m
Deal found 8/23![Frontier logo]()
$309
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:30 pm -
1 stop4h 15m
Mon 9/147:19 pm -
1 stop5h 22m
Deal found 8/24![American Airlines logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:29 pm -
1 stop22h 30m
Sun 9/207:54 pm -
1 stop23h 40m
Deal found 8/23![Frontier logo]()
$272
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:40 am -
1 stop4h 54m
Sat 9/265:00 pm -
1 stop5h 53m
Deal found 8/25![Delta logo]()
$310
This CheapOair deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:29 am -
1 stop6h 30m
Sun 9/277:54 pm -
1 stop24h 39m
Deal found 8/24![Frontier logo]()
$289
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:55 am -
1 stop5h 35m
Wed 9/304:00 pm -
1 stop7h 47m
Deal found 8/23![United Airlines logo]()
$271
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2612:10 pm -
2 stops10h 45m
Wed 9/306:36 pm -
1 stop4h 17m
Deal found 8/27![Delta logo]()
$315
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:30 pm -
1 stop6h 38m
Wed 10/76:30 am -
1 stop5h 12m
Deal found 8/27![American Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:29 pm -
1 stop22h 30m
Sun 10/45:38 pm -
1 stop18h 04m
Deal found 8/26![Multiple Airlines logo]()
$318
One-way flights from Iowa to South CarolinaSearch for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 27, 2026.
Search for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 27, 2026.
This Frontier deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2711:29 am -
1 stop6h 30m
Deal found 8/26![Frontier logo]()
$111
This Jetabroad deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Jetabroad is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:29 pm -
1 stop22h 30m
Deal found 8/23![Frontier logo]()
$128
This Priceline deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:29 am -
1 stop6h 30m
Deal found 8/25![Frontier logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:04 pm -
1 stop30h 29m
Deal found 8/25![Multiple Airlines logo]()
$130
This CheapOair deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:29 pm -
1 stop22h 30m
Deal found 8/27![Frontier logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:25 am -
2 stops25h 12m
Deal found 8/22![Multiple Airlines logo]()
$140
This CheapOair deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:25 pm -
1 stop18h 37m
Deal found 8/24![Frontier logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1911:54 am -
2 stops19h 43m
Deal found 8/25![Multiple Airlines logo]()
$146
This Kiwi.com deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2110:52 am -
2 stops44h 43m
Deal found 8/24![Multiple Airlines logo]()
$147
This CheapOair deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:59 pm -
1 stop18h 03m
Deal found 8/27![Frontier logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/258:00 am -
3 stops56h 05m
Deal found 8/26![Multiple Airlines logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/188:43 am -
1 stop6h 55m
Deal found 8/25![Multiple Airlines logo]()
$151
Find flight deals from Iowa to South Carolina
Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated August 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $256 (Kiwi.com) |
One-way from | $111 (Frontier) |
Popular in | July |
Cheapest in | January |
Average price | $391 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 27, 2026.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Cedar RapidsMyrtle Beach
CID Cedar Rapids - MYR Myrtle Beach Intl
CIDMYR
Cedar Rapids
Wed 10/14
1:37 pm-7:30 pm
1 stop4h 53m
Myrtle Beach Intl
Wed 10/21
8:01 pm-11:58 pm
1 stop4h 57m
$271
Cedar RapidsSavannah
CID Cedar Rapids - SAV Savannah/Hilton Head
CIDSAV
Cedar Rapids
Tue 11/10
5:15 am-11:35 am
1 stop5h 20m
Savannah/Hilton Head
Sat 11/14
7:12 am-4:08 pm
2 stops9h 56m
$276
Cedar RapidsSavannah
CID Cedar Rapids - SAV Savannah/Hilton Head
CIDSAV
Cedar Rapids
Sat 10/10
5:23 am-1:24 pm
1 stop7h 01m
Savannah/Hilton Head
Wed 10/14
11:19 am-9:37 pm
2 stops11h 18m
$276
Quickest round-trip
Des MoinesMyrtle Beach
DSM Des Moines - MYR Myrtle Beach Intl
DSMMYR
Des Moines
Sat 10/24
5:50 am-11:00 am
1 stop4h 10m
Myrtle Beach Intl
Tue 10/27
7:50 am-11:30 am
1 stop4h 40m
$297
Cedar RapidsSavannah
CID Cedar Rapids - SAV Savannah/Hilton Head
CIDSAV
Cedar Rapids
Sat 9/26
5:40 am-11:34 am
1 stop4h 54m
Savannah/Hilton Head
Wed 9/30
5:30 am-11:22 am
2 stops6h 52m
$300
Des MoinesMyrtle Beach
DSM Des Moines - MYR Myrtle Beach Intl
DSMMYR
Des Moines
Sat 11/7
5:20 am-12:55 pm
2 stops6h 35m
Myrtle Beach Intl
Wed 11/11
3:25 pm-10:00 pm
2 stops7h 35m
$307
Des MoinesMyrtle Beach
DSM Des Moines - MYR Myrtle Beach Intl
DSMMYR
Des Moines
Sat 10/17
5:50 am-5:15 pm
2 stops10h 25m
Myrtle Beach Intl
Tue 10/20
2:10 pm-10:00 pm
2 stops8h 50m
$307
Des MoinesMyrtle Beach
DSM Des Moines - MYR Myrtle Beach Intl
DSMMYR
Des Moines
Tue 10/13
5:35 am-7:25 pm
2 stops12h 50m
Myrtle Beach Intl
Tue 10/20
7:50 am-11:30 am
1 stop4h 40m
$308
Des MoinesMyrtle Beach
DSM Des Moines - MYR Myrtle Beach Intl
DSMMYR
Des Moines
Sat 10/17
5:45 am-3:02 pm
1 stop8h 17m
Myrtle Beach Intl
Tue 10/20
5:00 pm-11:35 pm
1 stop7h 35m
$324
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Tue 11/10
5:30 am-11:52 am
1 stop5h 22m
Charleston
Sat 11/14
6:00 am-10:51 am
1 stop5h 51m
$325
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
CID-SAV
OMA-CLT
DSM-CLT
DSM-MYR
CID-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to South Carolina
USIA-USSC
CID-SAV
OMA-CLT
DSM-CLT
DSM-MYR
What is the cheapest month to book a flight from Iowa to South Carolina?
Currently, February is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $317). Flying from Iowa to South Carolina in March is currently the most expensive (average of $481). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Iowa to South Carolina?
Airfare is typical for this route at the moment.
Iowa to South Carolina flights typically cost between $305 and $578 in September.The cheapest round-trip price found within the last 5 days was $325 on American Airlines (Sep 30-Oct 3).
How far ahead should I book a flight from Iowa to South Carolina?
The best time to book flights from Iowa to South Carolina is 72 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 27, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Food
7.0
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Iowa to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to South Carolina by cabin class
Find flights from Iowa to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and South Carolina flights
Browse other Iowa and South Carolina flight options. Last updated on August 27, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Iowa after your stay in South Carolina
Iowa to South Carolina flights
Consider these flights traveling from Iowa to South Carolina.
Top 4 airlines flying from Iowa to South Carolina
Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$243 | Average$412 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$448 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$429 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$344 | Average$412 | FlexibilityNo cancel fee | On-time63% |