$106+ Cheap flights from Iowa to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Jun 12 — Jun 191
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to South Carolina
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Cheapest flights from Iowa to South CarolinaExplore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 13, 2026.
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 13, 2026.
This Booking.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/88:24 pm
CID
- CLT
1 stop20h 54m
Frontier
Wed 8/1210:14 pm
CLT
- CID
1 stop16h 00m
Frontier
Deal found 5/12![Frontier logo]()
$222
This Booking.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:05 pm
OMA
- CLT
1 stop21h 13m
Frontier
Fri 8/710:14 pm
CLT
- OMA
1 stop22h 06m
Frontier
Deal found 5/13![Frontier logo]()
$222
This TravelUp deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure TravelUp is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/118:15 pm
OMA
- CLT
1 stop24h 10m
Frontier
Wed 6/1710:14 pm
CLT
- OMA
1 stop22h 16m
Frontier
Deal found 5/11![Frontier logo]()
$232
This Booking.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:56 pm
OMA
- CLT
1 stop21h 23m
Frontier
Sat 6/1310:14 pm
CLT
- OMA
1 stop22h 16m
Frontier
Deal found 5/12![Frontier logo]()
$236
This Booking.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:16 pm
CID
- CLT
1 stop21h 03m
Frontier
Mon 9/710:14 pm
CLT
- CID
1 stop15h 56m
Frontier
Deal found 5/12![Frontier logo]()
$242
This Booking.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/68:05 pm
OMA
- CLT
1 stop21h 13m
Frontier
Thu 7/97:14 pm
CLT
- OMA
1 stop25h 06m
Frontier
Deal found 5/12![Frontier logo]()
$242
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:45 am
CID
- MYR
1 stop3h 59m
Delta
Sat 7/44:17 pm
MYR
- CID
1 stop6h 49m
Delta
Deal found 5/11![Delta logo]()
$261
This Booking.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:56 pm
OMA
- CLT
1 stop21h 23m
Frontier
Mon 6/2210:14 pm
CLT
- OMA
1 stop22h 16m
Frontier
Deal found 5/8![Frontier logo]()
$262
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:00 am
CID
- MYR
2 stops8h 32m
American Airlines
Wed 7/14:17 pm
MYR
- CID
1 stop6h 46m
American Airlines
Deal found 5/12![American Airlines logo]()
$266
This Booking.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/228:15 pm
OMA
- CLT
1 stop21h 04m
Frontier
Fri 6/2610:14 pm
CLT
- OMA
1 stop22h 16m
Frontier
Deal found 5/13![Frontier logo]()
$277
This CheapOair deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- CLT
1 stop27h 02m
Frontier
Thu 6/47:14 pm
CLT
- DSM
1 stop19h 17m
Frontier
Deal found 5/9![Frontier logo]()
$280
This Booking.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/28:05 pm
OMA
- CLT
1 stop24h 18m
Frontier
Thu 8/67:14 pm
CLT
- OMA
1 stop25h 06m
Frontier
Deal found 5/11![Frontier logo]()
$282
Best flights from Iowa to South CarolinaDiscover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 13, 2026.
Discover carefully curated flight deals from Iowa to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 13, 2026.
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:45 am
CID
- MYR
1 stop3h 59m
Delta
Sat 7/44:17 pm
MYR
- CID
1 stop6h 49m
Delta
Deal found 5/11![Delta logo]()
$261
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:00 am
CID
- MYR
2 stops8h 32m
American Airlines
Wed 7/14:17 pm
MYR
- CID
2 stops8h 34m
American Airlines
Deal found 5/12![American Airlines logo]()
$271
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/103:45 pm
DSM
- CHS
1 stop4h 40m
Southwest
Wed 6/176:10 am
CHS
- DSM
1 stop6h 20m
Southwest
Deal found 5/11![Southwest logo]()
$355
This United Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:30 am
MLI
- CLT
1 stop6h 20m
United Airlines
Wed 8/1210:25 am
CLT
- MLI
2 stops10h 06m
United Airlines
Deal found 5/12![United Airlines logo]()
$358
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:24 pm
CID
- MYR
2 stops16h 15m
Multiple Airlines
Wed 8/194:21 pm
MYR
- CID
1 stop26h 07m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$363
This Delta deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:00 am
CID
- MYR
1 stop6h 33m
Delta
Tue 8/2511:33 am
MYR
- CID
2 stops11h 39m
Delta
Deal found 5/13![Delta logo]()
$266
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:00 am
CID
- MYR
1 stop5h 38m
American Airlines
Wed 8/195:15 pm
MYR
- CID
1 stop6h 38m
American Airlines
Deal found 5/9![American Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2412:09 pm
CID
- MYR
2 stops10h 46m
Delta
Wed 7/294:16 pm
MYR
- CID
1 stop6h 50m
Delta
Deal found 5/10![Delta logo]()
$325
This United Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:00 am
DSM
- CHS
1 stop4h 27m
United Airlines
Wed 10/147:00 am
CHS
- DSM
2 stops8h 11m
United Airlines
Deal found 5/11![United Airlines logo]()
$360
This Southwest deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/143:45 pm
DSM
- CHS
1 stop4h 40m
Southwest
Wed 7/223:00 pm
CHS
- DSM
2 stops8h 45m
Southwest
Deal found 5/10![Southwest logo]()
$360
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:00 am
CID
- MYR
2 stops8h 32m
American Airlines
Wed 6/174:17 pm
MYR
- CID
2 stops8h 34m
American Airlines
Deal found 5/13![American Airlines logo]()
$356
This Southwest deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/273:35 pm
DSM
- CHS
1 stop4h 40m
Southwest
Sat 7/45:30 am
CHS
- DSM
1 stop7h 05m
Southwest
Deal found 5/12![Southwest logo]()
$375
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:45 am
CID
- MYR
1 stop6h 50m
Delta
Wed 10/2111:10 am
MYR
- CID
2 stops11h 41m
Delta
Deal found 5/9![Delta logo]()
$341
This United Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/910:00 am
OMA
- SAV
1 stop7h 19m
United Airlines
Sat 9/127:05 pm
SAV
- OMA
1 stop5h 16m
United Airlines
Deal found 5/8![United Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:04 pm
OMA
- CHS
1 stop5h 44m
American Airlines
Tue 6/96:18 pm
CHS
- OMA
1 stop7h 03m
American Airlines
Deal found 5/8![American Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:35 am
DSM
- CHS
2 stops7h 35m
Southwest
Mon 10/193:15 pm
CHS
- DSM
2 stops9h 15m
Southwest
Deal found 5/12![Southwest logo]()
$376
This Delta deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:33 pm
OMA
- MYR
1 stop4h 26m
Delta
Mon 6/224:17 pm
MYR
- OMA
1 stop5h 37m
Delta
Deal found 5/13![Delta logo]()
$349
This United Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/131:36 pm
OMA
- SAV
1 stop6h 43m
United Airlines
Tue 8/183:35 pm
SAV
- OMA
1 stop8h 48m
United Airlines
Deal found 5/11![United Airlines logo]()
$388
This Southwest deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/203:35 pm
DSM
- MYR
1 stop4h 30m
Southwest
Wed 6/247:55 am
MYR
- DSM
1 stop4h 35m
Southwest
Deal found 5/10![Southwest logo]()
$379
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2112:20 pm
CID
- MYR
2 stops8h 24m
American Airlines
Thu 7/306:33 am
MYR
- CID
1 stop6h 02m
American Airlines
Deal found 5/13![American Airlines logo]()
$384
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/911:28 am
DSM
- MYR
1 stop6h 39m
Delta
Tue 6/166:00 am
MYR
- DSM
1 stop5h 43m
Delta
Deal found 5/12![Delta logo]()
$351
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/13:13 pm
OMA
- SAV
1 stop5h 43m
United Airlines
Tue 8/114:59 pm
SAV
- OMA
1 stop5h 59m
United Airlines
Deal found 5/13![United Airlines logo]()
$397
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/194:40 pm
DSM
- MYR
1 stop5h 05m
Southwest
Tue 6/237:55 am
MYR
- DSM
1 stop4h 35m
Southwest
Deal found 5/11![Southwest logo]()
$379
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:39 pm
DSM
- MYR
1 stop4h 20m
Delta
Tue 6/236:00 am
MYR
- DSM
1 stop5h 43m
Delta
Deal found 5/11![Delta logo]()
$351
This United Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/83:13 pm
OMA
- SAV
1 stop5h 43m
United Airlines
Mon 6/1511:30 am
SAV
- OMA
1 stop6h 58m
United Airlines
Deal found 5/11![United Airlines logo]()
$416
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/63:35 pm
DSM
- MYR
1 stop4h 30m
Southwest
Sat 6/136:35 am
MYR
- DSM
1 stop6h 00m
Southwest
Deal found 5/8![Southwest logo]()
$381
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:00 am
MLI
- CLT
1 stop6h 10m
Delta
Wed 8/125:30 am
CLT
- MLI
1 stop5h 55m
Delta
Deal found 5/12![Delta logo]()
$353
This United Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:00 am
OMA
- SAV
1 stop7h 16m
United Airlines
Thu 7/168:00 am
SAV
- OMA
1 stop7h 17m
United Airlines
Deal found 5/8![United Airlines logo]()
$427
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/115:56 am
MLI
- CLT
1 stop6h 35m
Delta
Tue 7/145:30 am
CLT
- MLI
1 stop5h 52m
Delta
Deal found 5/12![Delta logo]()
$353
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:20 am
DSM
- CLT
1 stop4h 50m
Southwest
Wed 6/178:20 am
CLT
- DSM
1 stop4h 10m
Southwest
Deal found 5/11![Southwest logo]()
$393
Last-minute flights from Iowa to South CarolinaDiscover last-minute flight deals from Iowa to South Carolina. Data last updated May 13, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to South Carolina. Data last updated May 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2911:43 am
CID
- MYR
2 stops9h 04m
American Airlines
Fri 6/54:39 pm
MYR
- CID
1 stop7h 52m
American Airlines
Deal found 5/11![American Airlines logo]()
$295
This CheapOair deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- CLT
1 stop27h 02m
Frontier
Thu 6/47:14 pm
CLT
- DSM
1 stop19h 17m
Frontier
Deal found 5/9![Frontier logo]()
$280
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/28:42 am
OMA
- MYR
1 stop4h 48m
Delta
Wed 6/174:17 pm
MYR
- OMA
1 stop5h 37m
Delta
Deal found 5/11![Delta logo]()
$325
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:05 pm
DSM
- CLT
1 stop10h 58m
American Airlines
Sat 6/611:25 am
CLT
- DSM
Nonstop2h 27m
American Airlines
Deal found 5/11![American Airlines logo]()
$323
This Booking.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:56 pm
OMA
- CLT
1 stop21h 23m
Frontier
Sat 6/1310:14 pm
CLT
- OMA
1 stop22h 16m
Frontier
Deal found 5/12![Frontier logo]()
$236
This Booking.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:56 pm
OMA
- CLT
1 stop21h 23m
Frontier
Mon 6/2210:14 pm
CLT
- OMA
1 stop22h 16m
Frontier
Deal found 5/8![Frontier logo]()
$262
This Mytrip deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/108:15 pm
OMA
- CLT
1 stop21h 04m
Frontier
Tue 6/167:14 pm
CLT
- OMA
1 stop25h 16m
Frontier
Deal found 5/13![Frontier logo]()
$295
This TravelUp deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure TravelUp is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/118:15 pm
OMA
- CLT
1 stop24h 10m
Frontier
Wed 6/1710:14 pm
CLT
- OMA
1 stop22h 16m
Frontier
Deal found 5/11![Frontier logo]()
$232
This Booking.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/228:15 pm
OMA
- CLT
1 stop21h 04m
Frontier
Fri 6/2610:14 pm
CLT
- OMA
1 stop22h 16m
Frontier
Deal found 5/13![Frontier logo]()
$277
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:00 am
CID
- MYR
1 stop4h 52m
American Airlines
Mon 6/296:06 pm
MYR
- CID
2 stops6h 45m
American Airlines
Deal found 5/12![American Airlines logo]()
$316
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:00 am
CID
- MYR
2 stops8h 32m
American Airlines
Wed 7/14:17 pm
MYR
- CID
1 stop6h 46m
American Airlines
Deal found 5/12![American Airlines logo]()
$266
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:45 am
CID
- MYR
1 stop3h 59m
Delta
Sat 7/44:17 pm
MYR
- CID
1 stop6h 49m
Delta
Deal found 5/11![Delta logo]()
$261
One-way flights from Iowa to South CarolinaSearch for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated May 13, 2026.
Search for one-way flight options from Iowa to South Carolina. Find affordable one-way fares based on user searches. Data last updated May 13, 2026.
This Booking.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/248:15 pm
OMA
- CLT
1 stop21h 04m
Frontier
Deal found 5/9![Frontier logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:24 pm
CID
- CLT
1 stop16h 38m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$114
This Trip.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:19 pm
OMA
- CLT
1 stop20h 59m
Frontier
Deal found 5/11![Frontier logo]()
$114
This CheapOair deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- CLT
1 stop27h 03m
Frontier
Deal found 5/9![Frontier logo]()
$120
This CheapOair deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:19 pm
DSM
- CLT
1 stop26h 59m
Frontier
Deal found 5/10![Frontier logo]()
$126
This Booking.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/128:05 pm
OMA
- CLT
1 stop24h 18m
Frontier
Deal found 5/11![Frontier logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:55 pm
CID
- CLT
1 stop17h 07m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:07 pm
DSM
- CLT
1 stop16h 55m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/295:45 pm
DSM
- CLT
2 stops26h 50m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$142
This Trip.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/48:16 pm
CID
- CLT
1 stop21h 02m
Frontier
Deal found 5/9![Frontier logo]()
$144
This Trip.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/48:15 pm
OMA
- CLT
1 stop21h 03m
Frontier
Deal found 5/9![Frontier logo]()
$144
This CheapOair deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- CLT
1 stop27h 02m
Frontier
Deal found 5/10![Frontier logo]()
$146
Find flight deals from Iowa to South Carolina
Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated May 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $222 (Booking.com) |
One-way from | $106 (Booking.com) |
Popular in | June |
Cheapest in | January |
Average price | $442 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 13, 2026.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Tue 6/30
5:45 am-10:44 am
1 stop3h 59m
Myrtle Beach Intl
Sat 7/4
4:17 pm-10:06 pm
1 stop6h 49m
$261
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Tue 8/11
6:00 am-1:33 pm
1 stop6h 33m
Myrtle Beach Intl
Tue 8/25
11:33 am-10:12 pm
2 stops11h 39m
$266
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Tue 6/23
6:00 am-3:32 pm
2 stops8h 32m
Myrtle Beach Intl
Wed 7/1
4:17 pm-11:51 pm
2 stops8h 34m
$271
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Sat 8/15
5:00 am-11:38 am
1 stop5h 38m
Myrtle Beach Intl
Wed 8/19
5:15 pm-10:53 pm
1 stop6h 38m
$304
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Fri 7/24
12:09 pm-11:55 pm
2 stops10h 46m
Myrtle Beach Intl
Wed 7/29
4:16 pm-10:06 pm
1 stop6h 50m
$325
Cedar RapidsMyrtle Beach
CID - MYR
CIDMYR
Cedar Rapids
Wed 10/14
5:45 am-1:35 pm
1 stop6h 50m
Myrtle Beach Intl
Wed 10/21
11:10 am-9:51 pm
2 stops11h 41m
$341
OmahaMyrtle Beach
OMA - MYR
OMAMYR
Omaha Eppley Airfield
Wed 6/17
6:33 pm-11:59 pm
1 stop4h 26m
Myrtle Beach Intl
Mon 6/22
4:17 pm-8:54 pm
1 stop5h 37m
$349
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Tue 6/9
11:28 am-7:07 pm
1 stop6h 39m
Myrtle Beach Intl
Tue 6/16
6:00 am-10:43 am
1 stop5h 43m
$351
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Wed 6/17
6:39 pm-11:59 pm
1 stop4h 20m
Myrtle Beach Intl
Tue 6/23
6:00 am-10:43 am
1 stop5h 43m
$351
MolineCharlotte
MLI - CLT
MLICLT
Moline Quad-City
Sat 8/8
6:00 am-1:10 pm
1 stop6h 10m
Charlotte Douglas
Wed 8/12
5:30 am-10:25 am
1 stop5h 55m
$353
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
OMA-CLT
CID-MYR
DSM-CLT
OMA-MYR
DSM-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to South Carolina
USIA-USSC
OMA-CLT
CID-MYR
DSM-CLT
OMA-MYR
How far ahead should I book a flight from Iowa to South Carolina?
The best time to book flights from Iowa to South Carolina is 60 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Iowa to South Carolina?
Currently, November is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $118). Flying from Iowa to South Carolina in March is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Iowa to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated May 13, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Comfort
8.0
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Comfort
8.0
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Comfort
8.0
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Comfort
8.0
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Comfort
8.0
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Iowa to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to South Carolina by cabin class
Find flights from Iowa to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and South Carolina flights
Browse other Iowa and South Carolina flight options. Last updated on May 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Iowa after your stay in South Carolina
Iowa to South Carolina flights
Consider these flights traveling from Iowa to South Carolina.
Top 4 airlines flying from Iowa to South Carolina
Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$237 | Average$414 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$242 | Average$401 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$431 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$272 | Average$406 | FlexibilityNo cancel fee | On-time63% |