South Carolina

$101+ Cheap flights from Iowa to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/9. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Jun 7 — Jun 141
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Cheap flight deals from Iowa to South Carolina

Cheapest flights from Iowa to South Carolina
Explore the most affordable flight options available from Iowa to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 8, 2026.

This Mytrip deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/128:05 pm
OMA
-
CLT
1 stop21h 13m
Frontier
Wed 8/1910:14 pm
CLT
-
OMA
1 stop22h 20m
Frontier
Deal found 5/6$199
This Mytrip deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:05 pm
OMA
-
CLT
1 stop21h 13m
Frontier
Sun 7/197:14 pm
CLT
-
OMA
1 stop25h 06m
Frontier
Deal found 5/6$219
This CheapOair deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/98:25 pm
OMA
-
CLT
1 stop24h 00m
Frontier
Fri 6/1210:14 pm
CLT
-
OMA
1 stop22h 16m
Frontier
Deal found 5/5$220
This Mytrip deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/98:25 pm
OMA
-
CLT
1 stop24h 00m
Frontier
Sat 6/1310:14 pm
CLT
-
OMA
1 stop22h 16m
Frontier
Deal found 5/6$239
This Mytrip deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/128:05 pm
OMA
-
CLT
1 stop24h 18m
Frontier
Mon 7/2010:14 pm
CLT
-
OMA
1 stop22h 06m
Frontier
Deal found 5/6$240
This Mytrip deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/98:05 pm
OMA
-
CLT
1 stop24h 18m
Frontier
Fri 9/410:14 pm
CLT
-
OMA
1 stop22h 20m
Frontier
Deal found 5/6$241
This Mytrip deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:19 pm
OMA
-
CLT
1 stop24h 05m
Frontier
Sun 8/307:14 pm
CLT
-
OMA
1 stop25h 20m
Frontier
Deal found 5/7$254
This Mytrip deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:56 pm
OMA
-
CLT
1 stop21h 23m
Frontier
Mon 6/1510:14 pm
CLT
-
OMA
1 stop22h 16m
Frontier
Deal found 5/6$260
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:00 am
CID
-
MYR
1 stop4h 53m
American Airlines
Wed 7/14:17 pm
MYR
-
CID
1 stop6h 46m
American Airlines
Deal found 5/6$261
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:37 pm
DSM
-
CLT
1 stop11h 39m
American Airlines
Thu 8/2011:30 am
CLT
-
DSM
Nonstop2h 24m
American Airlines
Deal found 5/6$273
This CheapOair deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
-
CLT
1 stop27h 02m
Frontier
Thu 6/47:14 pm
CLT
-
DSM
1 stop19h 17m
Frontier
Deal found 5/5$280
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2911:43 am
CID
-
MYR
2 stops9h 04m
American Airlines
Fri 6/54:39 pm
MYR
-
CID
1 stop7h 52m
American Airlines
Deal found 5/5$290

Find flight deals from Iowa to South Carolina

Keep the following information in mind while searching for Iowa to South Carolina flight deals. Data was last updated May 8, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$199
(Mytrip)

One-way from

$101
(CheapOair)

Popular in

November

Cheapest in

January

Average price

$386
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
From Iowa to South Carolina
One-way flight from Iowa to South Carolina
Highest demand for flights based on searches. 7% potential increase in price ($31 potential increase over avg. RT price).
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Average for round-trip flights in May 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 8, 2026.
Use the filters below to find and compare flights from Iowa to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

Tue 6/23

6:00 am-11:53 am

1 stop4h 53m

Myrtle Beach Intl

Wed 7/1

4:17 pm-10:03 pm

1 stop6h 46m

$261

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Fri 8/7

12:29 pm-10:24 pm

2 stops8h 55m

Charleston

Mon 8/10

5:06 pm-10:12 pm

1 stop6h 06m

$328

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Wed 8/26

6:00 am-11:54 am

1 stop4h 54m

Charleston

Wed 9/2

7:10 am-3:44 pm

2 stops9h 34m

$328

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

Mon 8/10

5:00 am-11:38 am

1 stop5h 38m

Myrtle Beach Intl

Sat 8/15

8:28 pm-11:58 pm

1 stop4h 30m

$328

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

Wed 8/5

6:34 am-11:24 am

1 stop3h 50m

Myrtle Beach Intl

Mon 8/10

5:15 pm-10:53 pm

1 stop6h 38m

$329

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 6/9

6:39 pm-11:59 pm

1 stop4h 20m

Myrtle Beach Intl

Tue 6/16

6:00 am-10:43 am

1 stop5h 43m

$335

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Tue 6/9

5:45 am-1:41 pm

1 stop6h 56m

Charleston

Tue 6/16

5:10 am-11:26 am

2 stops7h 16m

$338

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Tue 5/19

6:30 am-1:51 pm

1 stop6h 21m

Charleston

Sat 5/23

3:08 pm-9:36 pm

1 stop7h 28m

$339

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

Wed 10/14

5:45 am-1:35 pm

1 stop6h 50m

Myrtle Beach Intl

Wed 10/21

11:10 am-9:51 pm

2 stops11h 41m

$341

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

Sat 8/15

5:00 am-11:38 am

1 stop5h 38m

Myrtle Beach Intl

Wed 8/19

5:15 pm-10:53 pm

1 stop6h 38m

$346

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/4

Showing 1-10 of 60 resultsSorted by cheapest first
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6

Best time to book a flight from Iowa to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to South Carolina

How far ahead should I book a flight from Iowa to South Carolina?

The best time to book flights from Iowa to South Carolina is 60 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Iowa to South Carolina?

Currently, November is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $118). Flying from Iowa to South Carolina in March is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Iowa to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated May 8, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Iowa to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Boarding

8.1

Food

7.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Iowa to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How long is the flight from Iowa to South Carolina?

    Airlines like American Airlines, Delta, and United Airlines fly from Iowa to South Carolina in about 4h 53m. The time it takes to get you to your destination can typically vary by up to 4h 02m. The distance between Iowa and South Carolina is about 897 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Iowa to South Carolina that include hotel bookings?

    Yes. In addition to deals on Iowa to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to South Carolina.

  • Can I find deals for business class flights from Iowa to South Carolina?

    Yes. Cheapflights offers flight deals from Iowa to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to South Carolina?

    Currently, November is the cheapest month in which you can book a flight from Iowa to South Carolina (average of $118). Flying from Iowa to South Carolina in March is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Iowa to South Carolina

Discover the top 4 airlines that operate flights from Iowa to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 8, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$236Average$414FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$242Average$401FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$443FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$272Average$406FlexibilityNo cancel feeOn-time63%

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