South America

$304+ Cheap flights from Des Moines (DSM) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BOG
Aug 3 — Aug 101
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to South America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to South America

Keep the following information in mind while searching for Des Moines to South America flight deals. Data was last updated July 29, 2025.

Round-trip from

$618
(United Airlines)

One-way from

$304
(Avianca)

Popular in

June

Cheapest in

April

Average price

$1,350
From Des Moines to South America
One-way flight from Des Moines to South America
Highest demand for flights based on searches. 21% potential increase in price ($321 potential increase over avg. RT price).
Cheapest flight prices on average. 9% potential price decrease ($108 potential savings vs. average RT price).
Average for round-trip flights in July 2025

Find flight deals from Des Moines to South America

Cheapest flights from Des Moines to South America
Explore the most affordable flight options available from Des Moines to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/105:44 amDSM - CTG
2 stops17h 47mDelta
Wed 9/179:12 pmCTG - DSM
2 stops20h 33mDelta
Deal found 7/26$622
This Avianca deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1011:35 amDSM - LIM
2 stops14h 10mMultiple Airlines
Wed 9/178:25 pmLIM - DSM
2 stops25h 20mMultiple Airlines
Deal found 7/27$639
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/136:13 pmDSM - BAQ
2 stops18h 32mAmerican Airlines
Fri 8/221:50 pmBAQ - DSM
2 stops25h 53mAmerican Airlines
Deal found 7/29$669
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/112:58 pmDSM - UIO
1 stop8h 27mUnited Airlines
Wed 9/1712:35 amUIO - DSM
1 stop13h 42mUnited Airlines
Deal found 7/28$669
This LATAM Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1111:25 amDSM - UIO
1 stop8h 05mLATAM Airlines
Thu 9/1811:20 pmUIO - DSM
1 stop11h 20mLATAM Airlines
Deal found 7/28$700
This FlightHub deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/15:44 amDSM - LIM
2 stops14h 31mLATAM Airlines
Tue 11/2512:15 amLIM - DSM
2 stops18h 24mLATAM Airlines
Deal found 7/27$715
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/110:16 amDSM - LIM
2 stops17h 54mAmerican Airlines
Wed 11/2610:55 pmLIM - DSM
2 stops13h 12mAmerican Airlines
Deal found 7/27$723
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/185:44 amDSM - LIM
2 stops16h 01mDelta
Tue 9/3012:05 amLIM - DSM
2 stops22h 32mDelta
Deal found 7/28$724
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/185:49 pmDSM - GRU
3 stops43h 31mMultiple Airlines
Wed 10/15:25 amGRU - DSM
2 stops18h 20mMultiple Airlines
Deal found 7/28$735
This Trip.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:15 amDSM - LIM
1 stop16h 45mUnited Airlines
Tue 9/1612:40 amLIM - DSM
1 stop21h 48mUnited Airlines
Deal found 7/27$791
This lastminute.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lastminute.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:30 pmDSM - SCL
2 stops16h 50mLATAM Airlines
Wed 9/179:40 pmSCL - DSM
1 stop15h 00mLATAM Airlines
Deal found 7/27$795
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1111:25 amDSM - SCL
1 stop17h 35mDelta
Thu 9/189:40 pmSCL - DSM
1 stop17h 40mDelta
Deal found 7/27$804

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Des Moines to South America that are best for you.

Fly from

Des Moines

Fly to

South America

Route

Depart

Return

Price

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Fri 1/16

8:00 am-8:41 am

2 stops23h 41m

Cartagena Rafael Nunez

Tue 1/20

9:42 am-10:30 pm

2 stops37h 48m

$618

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Wed 9/10

5:44 am-11:31 pm

2 stops17h 47m

Cartagena Rafael Nunez

Wed 9/17

9:12 pm-5:45 pm

2 stops20h 33m

$622

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

Wed 9/10

11:35 am-1:45 am

2 stops14h 10m

Lima J Chavez Intl

Wed 9/17

8:25 pm-9:45 pm

2 stops25h 20m

$639

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Wed 8/13

6:13 pm-12:45 pm

2 stops18h 32m

Barranquilla E Cortissoz

Fri 8/22

1:50 pm-3:43 pm

2 stops25h 53m

$669

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

Thu 9/11

2:58 pm-11:25 pm

1 stop8h 27m

Quito Mariscal Sucr

Wed 9/17

12:35 am-2:17 pm

1 stop13h 42m

$669

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

Thu 9/11

11:25 am-7:30 pm

1 stop8h 05m

Quito Mariscal Sucr

Thu 9/18

11:20 pm-10:40 am

1 stop11h 20m

$700

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

Wed 10/1

6:30 pm-5:00 am

1 stop10h 30m

Lima J Chavez Intl

Tue 11/25

12:15 am-5:39 pm

2 stops18h 24m

$715

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

Wed 10/1

10:16 am-4:10 am

2 stops17h 54m

Lima J Chavez Intl

Wed 11/26

10:55 pm-11:07 am

2 stops13h 12m

$723

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

Thu 9/18

5:44 am-9:45 pm

2 stops16h 01m

Lima J Chavez Intl

Tue 9/30

12:05 am-10:37 pm

2 stops22h 32m

$724

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Fri 1/16

5:15 pm-2:15 pm

1 stop20h 00m

Cartagena Rafael Nunez

Tue 1/20

3:30 pm-10:23 am

1 stop19h 53m

$733

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Showing 1-10 of 41 results
1
2
3
...
5

Best time to book a flight from Des Moines to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to South America

What is the cheapest month to book a flight from Des Moines to South America?

Currently, May is the cheapest month in which you can book a flight from Des Moines to South America (average of $359). Flying from Des Moines to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SA?

Find hourly flight availability from Des Moines to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to South America as you normally would.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated July 29, 2025.
Read reviews from past customers who have flown Delta, LATAM Airlines, and Copa Airlines from Des Moines to South America. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
8.0
Very good

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
8.0
Very good
8.0
Very good

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
8.0
Very good

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
8.0
Very good

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
8.0
Very good

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
8.0
Very good

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Des Moines to South America?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South America.

  • What are the cheapest airlines to fly from Des Moines to South America one-way?

    For one-way options, check prices for Delta. According to our data, you can fly for as low as $370. Users have also found prices from $431 and $657 on LATAM Airlines and American Airlines, respectively.

  • What are the most popular routes from Des Moines to South America?

  • Can I find deals for flights from Des Moines to South America that include hotel bookings?

    Yes. In addition to deals on Des Moines to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South America.

  • Can I find deals for business class flights from Des Moines to South America?

    Yes. Cheapflights offers flight deals from Des Moines to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to South America?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to South America (average of $359). Flying from Des Moines to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Des Moines to South America

Discover the top 4 airlines that operate flights from Des Moines to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$488Average$849FlexibilityNo cancel feeOn-time71%
DeltaCheapest$503Average$938FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$585Average$706FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$631Average$1,167FlexibilityNo cancel feeOn-time81%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.