$191+ Cheap flights from Des Moines (DSM) to South America
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/25. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from Des Moines to South America with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to South America
Keep the following information in mind while searching for Des Moines to South America flight deals. Data was last updated June 12, 2025.
Round-trip from | $474 (Mytrip) |
|---|---|
One-way from | $191 (Mytrip) |
Popular in | June |
Cheapest in | April |
Average price | $2,165 |
Find flight deals from Des Moines to South America
Cheapest flights from Des Moines to South AmericaExplore the most affordable flight options available from Des Moines to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.
Explore the most affordable flight options available from Des Moines to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Avianca deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This FlightHub deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This LATAM Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Des Moines to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Des MoinesCartagena
DSM - CTG
DSMCTG
Des Moines
Sat 7/26
1:13 pm-12:15 pm
2 stops23h 02m
Cartagena Rafael Nunez
Sat 8/2
1:28 pm-10:38 pm
2 stops33h 10m
Des MoinesCartagena
DSM - CTG
DSMCTG
Des Moines
Sat 11/29
5:45 am-1:46 pm
1 stop7h 01m
Cartagena Rafael Nunez
Sat 12/6
3:06 pm-10:23 pm
1 stop8h 17m
Des MoinesCartagena
DSM - CTG
DSMCTG
Des Moines
Sat 11/29
4:26 pm-1:06 pm
2 stops19h 40m
Cartagena Rafael Nunez
Sat 12/6
4:21 pm-12:43 pm
2 stops21h 22m
Des MoinesLima
DSM - LIM
DSMLIM
Des Moines
Sun 8/24
11:35 am-1:45 am
2 stops14h 10m
Lima J Chavez Intl
Tue 9/2
2:50 am-9:45 pm
2 stops18h 55m
Des MoinesGuayaquil
DSM - GYE
DSMGYE
Des Moines
Mon 8/11
6:02 am-1:46 pm
2 stops31h 44m
Guayaquil Jose Joaquin de Olmedo
Tue 8/26
8:30 am-10:28 pm
2 stops37h 58m
Des MoinesQuito
DSM - UIO
DSMUIO
Des Moines
Tue 8/5
6:40 pm-8:03 pm
1 stop25h 23m
Quito Mariscal Sucr
Tue 8/19
11:15 pm-1:27 pm
1 stop14h 12m
Des MoinesQuito
DSM - UIO
DSMUIO
Des Moines
Tue 8/5
6:50 pm-11:25 pm
2 stops28h 35m
Quito Mariscal Sucr
Wed 8/20
12:35 am-10:28 pm
1 stop21h 53m
Des MoinesLima
DSM - LIM
DSMLIM
Des Moines
Sun 8/24
8:00 am-7:20 pm
2 stops35h 20m
Lima J Chavez Intl
Wed 9/3
6:45 pm-9:45 pm
2 stops27h 00m
Des MoinesQuito
DSM - UIO
DSMUIO
Des Moines
Wed 7/23
11:00 am-8:56 pm
3 stops33h 56m
Quito Mariscal Sucr
Wed 7/30
7:15 pm-10:38 pm
3 stops27h 23m
Des MoinesQuito
DSM - UIO
DSMUIO
Des Moines
Thu 8/7
5:30 am-8:03 pm
1 stop14h 33m
Quito Mariscal Sucr
Mon 8/18
11:20 pm-5:41 pm
1 stop18h 21m
Best time to book a flight from Des Moines to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Des Moines with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to South America
What is the cheapest month to book a flight from Des Moines to South America?
Currently, May is the cheapest month in which you can book a flight from Des Moines to South America (average of $359). Flying from Des Moines to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DSM to SA?
Find hourly flight availability from Des Moines to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to South America as you normally would.
Rainfall in South America by month
Plan your trip to South America by taking into account the average rainfall totals by month.
In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.
Temperature in South America by month
Plan your trip to South America by taking into account the average temperature totals by month.
If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).
Reviews of airlines servicing South America
Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated June 12, 2025.
Boarding
Comfort
Food
Overall
Entertainment
Crew
Reviews
Kim,May 2025
PIH - SLC
Boarding
Comfort
Food
Overall
Entertainment
Crew
Reviews
Kim,May 2025
PIH - SLC
Boarding
Comfort
Food
Overall
Entertainment
Crew
Reviews
Kim,May 2025
PIH - SLC
Boarding
Comfort
Food
Overall
Entertainment
Crew
Reviews
Kim,May 2025
PIH - SLC
Boarding
Comfort
Food
Overall
Entertainment
Crew
Reviews
Kim,May 2025
PIH - SLC
Boarding
Comfort
Food
Overall
Entertainment
Crew
Reviews
Kim,May 2025
PIH - SLC
Related info for your journey
Find useful and relevant information for your journey from Des Moines to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to South America
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from Des Moines to South America
Discover the top 4 airlines that operate flights from Des Moines to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$477 | Average$899 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$503 | Average$871 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$585 | Average$706 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$631 | Average$1,130 | FlexibilityNo cancel fee | On-time81% |