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South America

$366+ Cheap flights from Des Moines (DSM) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BOG
oct. 11 — oct. 181
sam. 10/11
sam. 10/18
1 adult, Economy
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Cheap flight deals from Des Moines to South America

Keep the following information in mind while searching for Des Moines to South America flight deals. Data was last updated septembre 11, 2025.

Round-trip from

$467
(Kiwi.com)

One-way from

$366
(American Airlines)

Popular in

June

Cheapest in

March

Average price

$1,178
From Des Moines to South America
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One-way flight from Des Moines to South America
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Highest demand for flights based on searches. 23% potential increase in price ($350 potential increase over avg. RT price).
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Cheapest flight prices on average. 10% potential price decrease ($111 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to South America

Cheapest flights from Des Moines to South America
Explore the most affordable flight options available from Des Moines to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septembre 11, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 10/2610:41 amDSM - CTG
1 stop25h 44mMultiple Airlines
dim. 11/22:32 pmCTG - DSM
2 stops23h 21mMultiple Airlines
Deal found 9/11$467
This Mytrip deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 10/268:47 pmDSM - LIM
2 stops26h 23mMultiple Airlines
dim. 11/210:03 amLIM - DSM
2 stops27h 50mMultiple Airlines
Deal found 9/11$600
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/68:00 amDSM - UIO
2 stops28h 27mMultiple Airlines
jeu. 10/95:15 pmUIO - DSM
1 stop21h 35mMultiple Airlines
Deal found 9/10$616
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 10/266:05 amDSM - CTG
2 stops26h 36mUnited Airlines
dim. 11/29:42 amCTG - DSM
2 stops37h 38mUnited Airlines
Deal found 9/11$618
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 10/510:41 amDSM - UIO
2 stops35h 44mMultiple Airlines
jeu. 10/95:15 pmUIO - DSM
1 stop21h 35mMultiple Airlines
Deal found 9/10$661
This Mytrip deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 10/268:47 pmDSM - UIO
3 stops38h 33mMultiple Airlines
dim. 11/28:05 amUIO - DSM
3 stops29h 48mMultiple Airlines
Deal found 9/11$686
This LATAM Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 10/265:47 amDSM - UIO
1 stop13h 08mLATAM Airlines
sam. 11/112:55 amUIO - DSM
1 stop10h 10mLATAM Airlines
Deal found 9/11$720
This Mytrip deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 10/268:47 pmDSM - SCL
3 stops39h 53mMultiple Airlines
dim. 11/25:50 amSCL - DSM
3 stops34h 03mMultiple Airlines
Deal found 9/11$723
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/710:50 amDSM - UIO
1 stop8h 09mDelta
jeu. 10/912:59 amUIO - DSM
1 stop9h 06mDelta
Deal found 9/10$734
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 10/265:47 amDSM - UIO
1 stop13h 08mDelta
sam. 11/112:55 amUIO - DSM
1 stop10h 10mDelta
Deal found 9/10$744
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dim. 10/266:05 amDSM - LIM
2 stops15h 25mAmerican Airlines
dim. 11/27:00 amLIM - DSM
1 stop17h 33mAmerican Airlines
Deal found 9/11$784
This LATAM Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 10/82:13 pmDSM - SCL
1 stop14h 47mLATAM Airlines
mer. 10/159:40 pmSCL - DSM
1 stop14h 25mLATAM Airlines
Deal found 9/10$784

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septembre 11, 2025.
Use the filters below to find and compare flights from Des Moines to South America that are best for you.

Fly from

Des Moines

Fly to

South America

Route

Depart

Return

Price

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

dim. 10/26

10:41 am-12:25 pm

1 stop25h 44m

Cartagena Rafael Nunez

dim. 11/2

2:32 pm-12:53 pm

2 stops23h 21m

$467

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

dim. 10/26

8:47 pm-11:10 pm

2 stops26h 23m

Lima J Chavez Intl

dim. 11/2

10:03 am-12:53 pm

2 stops27h 50m

$600

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

dim. 10/26

6:05 am-8:41 am

2 stops26h 36m

Cartagena Rafael Nunez

dim. 11/2

9:42 am-10:20 pm

2 stops37h 38m

$618

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

lun. 3/9

3:00 pm-8:41 am

2 stops41h 41m

Cartagena Rafael Nunez

jeu. 3/12

5:55 pm-10:30 pm

2 stops28h 35m

$630

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

lun. 3/9

5:45 am-1:15 pm

1 stop7h 30m

Cartagena Rafael Nunez

jeu. 3/12

2:30 pm-4:30 pm

1 stop26h 00m

$649

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

dim. 10/5

10:41 am-10:25 pm

2 stops35h 44m

Quito Mariscal Sucr

jeu. 10/9

5:15 pm-2:50 pm

1 stop21h 35m

$661

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

lun. 10/6

8:30 am-5:05 pm

2 stops32h 35m

Quito Mariscal Sucr

mer. 10/8

3:55 am-2:50 pm

2 stops34h 55m

$677

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

lun. 1/5

5:15 pm-8:55 pm

1 stop26h 40m

Lima J Chavez Intl

jeu. 1/22

12:15 pm-10:28 pm

1 stop11h 13m

$709

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

lun. 1/5

6:46 pm-11:55 pm

2 stops28h 09m

Lima J Chavez Intl

mer. 1/21

1:50 am-10:30 pm

1 stop21h 40m

$718

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

mar. 10/7

10:50 am-6:59 pm

1 stop8h 09m

Quito Mariscal Sucr

jeu. 10/9

12:59 am-10:05 am

1 stop9h 06m

$734

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Showing 1-10 of 44 results
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Best time to book a flight from Des Moines to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to South America

What is the cheapest month to book a flight from Des Moines to South America?

Currently, May is the cheapest month in which you can book a flight from Des Moines to South America (average of $359). Flying from Des Moines to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SA?

Find hourly flight availability from Des Moines to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septembre 11, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to South America as you normally would.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated septembre 11, 2025.
Read reviews from past customers who have flown Delta, LATAM Airlines, and United Airlines from Des Moines to South America. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,847 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South America?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South America.

  • How long is the flight from Des Moines to South America?

    Departing from Des Moines to South America will take you 7h 30m. Des Moines and South America are separated by a distance of 2413 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Des Moines to South America one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $366. Users have also found prices from $370 and $567 on LATAM Airlines and United Airlines, respectively.

  • What are the most popular routes from Des Moines to South America?

    The most popular flight routes from Des Moines to South America are Des Moines - Buenos Aires Ministro Pistarini, Des Moines - Sao Paulo Guarulhos Intl and Des Moines - Quito Mariscal Sucr.

  • Can I find deals for flights from Des Moines to South America that include hotel bookings?

    Yes. In addition to deals on Des Moines to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South America.

  • Can I find deals for business class flights from Des Moines to South America?

    Yes. Cheapflights offers flight deals from Des Moines to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to South America?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to South America (average of $359). Flying from Des Moines to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to South America

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Top 4 airlines flying from Des Moines to South America

Discover the top 4 airlines that operate flights from Des Moines to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septembre 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$488Average$679FlexibilityNo cancel feeOn-time71%
DeltaCheapest$503Average$1,059FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$585Average$706FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$631Average$1,123FlexibilityNo cancel feeOn-time81%

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