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South America

$166+ Cheap flights from Des Moines (DSM) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BOG
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Des Moines to South America

Cheapest flights from Des Moines to South America
Explore the most affordable flight options available from Des Moines to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:46 pmDSM - SCL
2 stops59h 04mUnited Airlines
Thu 12/2510:45 pmSCL - DSM
1 stop18h 34mUnited Airlines
Deal found 12/11$984
This United Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/108:15 amDSM - GYE
2 stops32h 21mUnited Airlines
Sun 12/2112:20 pmGYE - DSM
2 stops30h 45mUnited Airlines
Deal found 12/9$985
This Delta deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/205:35 amDSM - SCL
1 stop23h 05mDelta
Thu 12/2511:10 pmSCL - DSM
1 stop17h 28mDelta
Deal found 12/11$1,124
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2511:32 amDSM - CNF
2 stops24h 08mAmerican Airlines
Sun 1/257:10 pmCNF - DSM
2 stops18h 40mAmerican Airlines
Deal found 12/11$1,491
This Priceline deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2011:23 amDSM - SCL
2 stops39h 12mLATAM Airlines
Thu 12/253:05 pmSCL - DSM
3 stops34h 26mLATAM Airlines
Deal found 12/11$1,554
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 amDSM - CNF
2 stops29h 25mUnited Airlines
Sun 1/1812:35 pmCNF - DSM
2 stops36h 55mUnited Airlines
Deal found 12/10$1,564
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:46 pmDSM - SCL
2 stops35h 04mUnited Airlines
Mon 1/510:45 pmSCL - DSM
1 stop26h 45mUnited Airlines
Deal found 12/10$1,604
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/223:28 pmDSM - CNF
2 stops18h 27mAmerican Airlines
Fri 1/238:45 pmCNF - DSM
2 stops29h 44mAmerican Airlines
Deal found 12/10$1,714
This Priceline deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2711:23 amDSM - SCL
3 stops24h 07mLATAM Airlines
Mon 1/510:15 pmSCL - DSM
2 stops39h 23mLATAM Airlines
Deal found 12/10$1,837
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/203:00 pmDSM - EZE
1 stop13h 20mUnited Airlines
Sun 12/2811:55 pmEZE - DSM
1 stop17h 24mUnited Airlines
Deal found 12/11$1,891
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:00 amDSM - SCL
1 stop24h 25mAmerican Airlines
Mon 1/511:15 pmSCL - DSM
1 stop19h 00mAmerican Airlines
Deal found 12/10$1,958
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:17 pmDSM - UIO
2 stops13h 53mUnited Airlines
Fri 1/21:35 amUIO - DSM
2 stops21h 05mUnited Airlines
Deal found 12/10$2,017

Find flight deals from Des Moines to South America

Keep the following information in mind while searching for Des Moines to South America flight deals. Data was last updated December 12, 2025.

Round-trip from

$352
(Mytrip)

One-way from

$166
(Kiwi.com)
From Des Moines to South America
Search Deals
One-way flight from Des Moines to South America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Des Moines to South America that are best for you.

Fly from

Des Moines

Fly to

South America

Route

Depart

Return

Price

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sun 1/25

2:58 pm-12:21 am

1 stop32h 23m

Guayaquil Jose Joaquin de Olmedo

Sat 1/31

1:26 am-10:19 am

2 stops33h 53m

$354

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sun 2/15

3:32 pm-12:04 am

1 stop31h 32m

Guayaquil Jose Joaquin de Olmedo

Wed 2/25

4:40 am-11:06 pm

2 stops19h 26m

$399

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Sun 1/25

2:58 pm-1:15 pm

1 stop21h 17m

Cartagena Rafael Nunez

Sun 2/1

2:21 pm-10:19 am

2 stops20h 58m

$449

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sun 2/15

3:32 pm-12:04 am

1 stop31h 32m

Guayaquil Jose Joaquin de Olmedo

Mon 3/2

12:59 am-10:35 am

2 stops34h 36m

$457

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Thu 1/22

2:58 pm-1:15 pm

1 stop21h 17m

Cartagena Rafael Nunez

Thu 1/29

2:21 pm-10:46 pm

1 stop9h 25m

$471

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sun 2/15

3:32 pm-12:04 am

1 stop31h 32m

Guayaquil Jose Joaquin de Olmedo

Sat 2/28

12:59 am-7:39 pm

2 stops43h 40m

$483

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Sun 1/25

2:58 pm-2:44 pm

1 stop22h 46m

Barranquilla E Cortissoz

Sun 2/1

3:39 pm-10:19 am

2 stops19h 40m

$495

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Thu 2/12

3:32 pm-12:04 am

1 stop31h 32m

Guayaquil Jose Joaquin de Olmedo

Sat 2/28

12:59 am-7:39 pm

2 stops43h 40m

$550

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Tue 3/24

3:26 pm-12:32 pm

2 stops21h 06m

Barranquilla E Cortissoz

Tue 4/7

2:00 pm-11:57 am

2 stops21h 57m

$568

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

Sun 1/25

2:58 pm-10:35 pm

1 stop30h 37m

Lima J Chavez Intl

Sat 1/31

2:55 am-10:46 pm

2 stops20h 51m

$573

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 52 results
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Best time to book a flight from Des Moines to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to South America

What is the cheapest time of day to fly from DSM to SA?

Find hourly flight availability from Des Moines to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

A simple way to save on the total cost of your ticket is to fly from Des Moines to South America in the evening. If you’re flexible enough to do this you can expect to save up to 39% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated December 12, 2025.
Read reviews from past customers who have flown Delta, LATAM Airlines, and United Airlines from Des Moines to South America. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,009 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,009 reviews
Delta
7.9
Good
8,009 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,889 reviews
Delta
7.9
Good
8,009 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,095 reviews
Delta
7.9
Good
8,009 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,048 reviews
Delta
7.9
Good
8,009 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South America?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South America.

  • How long is the flight from Des Moines to South America?

    Departing from Des Moines to South America will take you 15h 20m. Des Moines and South America are separated by a distance of 3031 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Des Moines to South America?

    The most popular flight routes from Des Moines to South America are Des Moines - Barranquilla E Cortissoz, Des Moines - Buenos Aires Ministro Pistarini and Des Moines - Belo Horizonte Tancredo Neves Intl.

  • Can I find deals for flights from Des Moines to South America that include hotel bookings?

    Yes. In addition to deals on Des Moines to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South America.

  • Can I find deals for business class flights from Des Moines to South America?

    Yes. Cheapflights offers flight deals from Des Moines to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top 3 airlines flying from Des Moines to South America

Discover the top 3 airlines that operate flights from Des Moines to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$488Average$930FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$633Average$1,122FlexibilityNo cancel feeOn-time81%
DeltaCheapest$709Average$1,193FlexibilityNo cancel feeOn-timeN/A

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