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South America

$199+ Cheap flights from Des Moines (DSM) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BOG
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Des Moines to South America

Cheapest flights from Des Moines to South America
Explore the most affordable flight options available from Des Moines to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/223:32 pm
DSM
-
CTG
1 stop20h 38m
Multiple Airlines
Thu 2/262:21 pm
CTG
-
DSM
1 stop9h 45m
Multiple Airlines
Deal found 1/26$377
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/241:23 pm
DSM
-
BAQ
1 stop24h 10m
Multiple Airlines
Sat 4/42:40 pm
BAQ
-
DSM
2 stops23h 06m
Multiple Airlines
Deal found 1/25$424
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/241:23 pm
DSM
-
BAQ
1 stop24h 10m
Multiple Airlines
Fri 4/32:40 pm
BAQ
-
DSM
2 stops47h 06m
Multiple Airlines
Deal found 1/25$432
This Mytrip deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/188:04 am
DSM
-
LIM
2 stops16h 31m
Avianca
Fri 5/12:50 am
LIM
-
DSM
2 stops18h 30m
Avianca
Deal found 1/26$478
This Avianca deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/148:04 am
DSM
-
LIM
2 stops16h 31m
Multiple Airlines
Mon 4/273:05 am
LIM
-
DSM
2 stops19h 38m
Multiple Airlines
Deal found 1/26$480
This Mytrip deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:00 am
DSM
-
LIM
2 stops17h 45m
Avianca
Tue 9/16:45 pm
LIM
-
DSM
2 stops26h 11m
Avianca
Deal found 1/26$489
This Avianca deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/811:30 am
DSM
-
LIM
2 stops13h 05m
Multiple Airlines
Mon 9/213:05 am
LIM
-
DSM
2 stops19h 25m
Multiple Airlines
Deal found 1/26$491
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/193:59 pm
DSM
-
BAQ
1 stop21h 34m
Multiple Airlines
Thu 3/262:40 pm
BAQ
-
DSM
2 stops27h 52m
Multiple Airlines
Deal found 1/25$532
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/153:32 pm
DSM
-
GYE
1 stop31h 32m
Multiple Airlines
Sun 3/1511:59 pm
GYE
-
DSM
2 stops18h 28m
Multiple Airlines
Deal found 1/25$552
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/187:00 am
DSM
-
BAQ
1 stop7h 25m
American Airlines
Wed 4/11:39 pm
BAQ
-
DSM
1 stop10h 17m
American Airlines
Deal found 1/26$564
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/53:22 pm
DSM
-
BAQ
1 stop22h 21m
Multiple Airlines
Thu 3/122:40 pm
BAQ
-
DSM
2 stops28h 21m
Multiple Airlines
Deal found 1/25$572
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/52:02 pm
DSM
-
BAQ
2 stops22h 29m
American Airlines
Thu 3/121:30 pm
BAQ
-
DSM
1 stop10h 26m
American Airlines
Deal found 1/25$578

Find flight deals from Des Moines to South America

Keep the following information in mind while searching for Des Moines to South America flight deals. Data was last updated January 27, 2026.

Round-trip from

$377
(Kiwi.com)

One-way from

$199
(Kiwi.com)
From Des Moines to South America
Search Deals
One-way flight from Des Moines to South America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Des Moines to South America that are best for you.

Fly from

Des Moines

Fly to

South America

Route

Depart

Return

Price

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

Sun 2/22

3:32 pm-1:10 pm

1 stop20h 38m

Cartagena Rafael Nunez

Thu 2/26

2:21 pm-11:06 pm

1 stop9h 45m

$377

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Tue 3/24

1:23 pm-1:33 pm

1 stop24h 10m

Barranquilla E Cortissoz

Sat 4/4

2:40 pm-1:46 pm

2 stops23h 06m

$424

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

Tue 4/28

8:04 am-12:35 am

2 stops16h 31m

Lima J Chavez Intl

Fri 5/8

2:50 am-9:20 pm

2 stops18h 30m

$478

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Thu 3/19

3:59 pm-1:33 pm

1 stop21h 34m

Barranquilla E Cortissoz

Thu 3/26

2:40 pm-6:32 pm

2 stops27h 52m

$532

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sun 2/15

3:32 pm-12:04 am

1 stop31h 32m

Guayaquil Jose Joaquin de Olmedo

Sun 3/15

11:59 pm-6:27 pm

2 stops18h 28m

$552

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Wed 3/18

7:00 am-2:25 pm

1 stop7h 25m

Barranquilla E Cortissoz

Wed 4/1

1:39 pm-11:56 pm

1 stop10h 17m

$564

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Thu 3/26

7:00 am-2:25 pm

1 stop7h 25m

Barranquilla E Cortissoz

Fri 4/3

1:33 pm-1:07 pm

2 stops23h 34m

$569

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Tue 3/24

3:28 pm-9:45 am

2 stops18h 17m

Barranquilla E Cortissoz

Fri 4/3

4:01 pm-9:27 pm

2 stops29h 26m

$569

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Tue 3/24

3:26 pm-12:30 pm

2 stops21h 04m

Barranquilla E Cortissoz

Sat 4/4

3:25 pm-10:34 am

2 stops19h 09m

$569

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Thu 3/19

1:52 pm-12:30 pm

2 stops22h 38m

Barranquilla E Cortissoz

Thu 3/26

1:30 pm-11:56 pm

1 stop10h 26m

$578

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Showing 1-10 of 51 results
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Best time to book a flight from Des Moines to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to South America
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated January 27, 2026.
Read reviews from past customers who have flown Delta, LATAM Airlines, and United Airlines from Des Moines to South America. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,119 reviews

Crew

8.5

Food

7.2

Entertainment

7.8

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,119 reviews
Delta
7.9
Good
8,119 reviews

Crew

8.5

Food

7.2

Entertainment

7.8

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,912 reviews
Delta
7.9
Good
8,119 reviews

Crew

8.5

Food

7.2

Entertainment

7.8

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,205 reviews
Delta
7.9
Good
8,119 reviews

Crew

8.5

Food

7.2

Entertainment

7.8

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,197 reviews
Delta
7.9
Good
8,119 reviews

Crew

8.5

Food

7.2

Entertainment

7.8

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South America?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South America.

  • How long is the flight from Des Moines to South America?

    Departing from Des Moines to South America will take you 7h 25m. Des Moines and South America are separated by a distance of 2405 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Des Moines to South America?

    The most popular flight routes from Des Moines to South America are Des Moines - Lima J Chavez Intl, Des Moines - Barranquilla E Cortissoz and Des Moines - Sao Paulo Guarulhos Intl.

  • Can I find deals for flights from Des Moines to South America that include hotel bookings?

    Yes. In addition to deals on Des Moines to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South America.

  • Can I find deals for business class flights from Des Moines to South America?

    Yes. Cheapflights offers flight deals from Des Moines to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top 2 airlines flying from Des Moines to South America

Discover the top 2 airlines that operate flights from Des Moines to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$503Average$958FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$634Average$1,006FlexibilityNo cancel feeOn-time81%

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