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South America

$299+ Cheap flights from Des Moines (DSM) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BOG
nov. 28 — dic. 51
vie. 11/28
vie. 12/5
1 adult, Economy
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Cheap flight deals from Des Moines to South America

Keep the following information in mind while searching for Des Moines to South America flight deals. Data was last updated octubre 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$419
(Kiwi.com)

One-way from

$299
(Kiwi.com)
Provider with most accurate pricing for Des Moines-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Sao Paulo (SAO) flights.
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From Des Moines to South America
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One-way flight from Des Moines to South America
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Find flight deals from Des Moines to South America

Cheapest flights from Des Moines to South America
Explore the most affordable flight options available from Des Moines to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 29, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/112:56 pmDSM - CTG
1 stop21h 14mMultiple Airlines
jue. 12/182:15 pmCTG - DSM
1 stop9h 21mMultiple Airlines
Deal found 10/29$363
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/112:56 pmDSM - BAQ
1 stop22h 29mMultiple Airlines
jue. 12/183:20 pmBAQ - DSM
1 stop8h 16mMultiple Airlines
Deal found 10/27$495
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/112:56 pmDSM - LIM
1 stop30h 39mMultiple Airlines
jue. 12/1811:37 pmLIM - DSM
2 stops40h 20mMultiple Airlines
Deal found 10/27$600
This eDestinos deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/74:21 pmDSM - UIO
3 stops35h 56mMultiple Airlines
dom. 12/1411:45 pmUIO - DSM
2 stops16h 13mMultiple Airlines
Deal found 10/28$656
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/127:28 pmDSM - BAQ
2 stops17h 57mMultiple Airlines
vie. 12/193:20 pmBAQ - DSM
3 stops31h 27mMultiple Airlines
Deal found 10/28$697
This LATAM Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/115:34 amDSM - UIO
1 stop13h 26mLATAM Airlines
jue. 12/1811:45 pmUIO - DSM
1 stop11h 53mLATAM Airlines
Deal found 10/27$699
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/45:34 amDSM - UIO
1 stop13h 26mDelta
mié. 12/1711:45 pmUIO - DSM
1 stop11h 53mDelta
Deal found 10/27$701
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/116:00 amDSM - UIO
2 stops16h 02mAmerican Airlines
mié. 12/1712:54 amUIO - DSM
1 stop24h 04mAmerican Airlines
Deal found 10/27$704
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/76:50 pmDSM - UIO
2 stops28h 40mUnited Airlines
sáb. 12/131:35 amUIO - DSM
1 stop13h 37mUnited Airlines
Deal found 10/28$715
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/115:34 amDSM - UIO
1 stop13h 26mDelta
jue. 12/1811:45 pmUIO - DSM
2 stops22h 30mDelta
Deal found 10/27$717
This LATAM Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/75:34 amDSM - UIO
1 stop13h 26mLATAM Airlines
dom. 12/1411:45 pmUIO - DSM
1 stop11h 53mLATAM Airlines
Deal found 10/28$720
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/1211:35 amDSM - UIO
2 stops35h 55mUnited Airlines
jue. 12/181:35 amUIO - DSM
1 stop13h 44mUnited Airlines
Deal found 10/28$724

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 29, 2025.
Use the filters below to find and compare flights from Des Moines to South America that are best for you.

Fly from

Des Moines

Fly to

South America

Route

Depart

Return

Price

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

jue. 12/11

2:56 pm-1:10 pm

1 stop21h 14m

Cartagena Rafael Nunez

jue. 12/18

2:15 pm-10:36 pm

1 stop9h 21m

$419

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

jue. 12/11

2:56 pm-2:25 pm

1 stop22h 29m

Barranquilla E Cortissoz

jue. 12/18

3:20 pm-10:36 pm

1 stop8h 16m

$495

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

jue. 12/11

6:40 am-9:30 pm

2 stops13h 50m

Cartagena Rafael Nunez

jue. 12/18

8:00 am-11:58 pm

1 stop16h 58m

$594

Des MoinesCartagena

DSM - CTG

DSMCTG

Des Moines

vie. 1/16

4:00 pm-1:30 pm

2 stops20h 30m

Cartagena Rafael Nunez

mar. 1/20

4:30 pm-12:46 pm

2 stops21h 16m

$605

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

jue. 12/11

2:56 pm-10:35 pm

1 stop30h 39m

Lima J Chavez Intl

jue. 12/18

11:37 pm-2:57 pm

2 stops40h 20m

$614

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

lun. 3/9

5:45 am-6:42 pm

2 stops12h 57m

Barranquilla E Cortissoz

vie. 3/13

6:13 am-10:23 am

2 stops28h 10m

$621

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

lun. 3/9

7:15 am-11:36 pm

2 stops16h 21m

Barranquilla E Cortissoz

vie. 3/13

9:08 am-10:36 pm

2 stops37h 28m

$628

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

jue. 1/15

8:00 am-12:30 am

2 stops15h 30m

Quito Mariscal Sucr

mié. 1/28

1:35 am-2:22 pm

1 stop13h 47m

$643

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

jue. 1/15

6:00 am-11:47 pm

2 stops16h 47m

Quito Mariscal Sucr

jue. 1/29

7:04 am-11:29 pm

1 stop17h 25m

$643

Des MoinesQuito

DSM - UIO

DSMUIO

Des Moines

dom. 3/8

7:15 am-11:30 pm

1 stop16h 15m

Quito Mariscal Sucr

jue. 3/12

12:35 am-10:36 pm

1 stop22h 01m

$693

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 60 results
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Best time to book a flight from Des Moines to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to South America

What is the cheapest month to book a flight from Des Moines to South America?

Currently, February is the cheapest month in which you can book a flight from Des Moines to South America (average of $632). Flying from Des Moines to South America in April is currently the most expensive (average of $898). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SA?

Find hourly flight availability from Des Moines to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 29, 2025.

A simple way to save on the total cost of your ticket is to fly from Des Moines to South America in the evening. If you’re flexible enough to do this you can expect to save up to 28% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated octubre 29, 2025.
Read reviews from past customers who have flown Delta, LATAM Airlines, and United Airlines from Des Moines to South America. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Overall

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Overall

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
LATAM Airlines
7.5
Good
1,871 reviews
Delta
7.9
Good
7,994 reviews

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Overall

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
9,001 reviews
Delta
7.9
Good
7,994 reviews

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Overall

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,994 reviews

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Overall

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South America?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South America.

  • How long is the flight from Des Moines to South America?

    Departing from Des Moines to South America will take you 13h 26m. Des Moines and South America are separated by a distance of 3031 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Des Moines to South America one-way?

    For one-way options, check prices for LATAM Airlines. According to our data, you can fly for as low as $543. Users have also found prices from $543 and $564 on Delta and Copa Airlines, respectively.

  • What are the most popular routes from Des Moines to South America?

    The most popular flight routes from Des Moines to South America are Des Moines - Santiago Arturo Merino Benitez, Des Moines - Belo Horizonte Tancredo Neves Intl and Des Moines - Lima J Chavez Intl.

  • Can I find deals for flights from Des Moines to South America that include hotel bookings?

    Yes. In addition to deals on Des Moines to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South America.

  • Can I find deals for business class flights from Des Moines to South America?

    Yes. Cheapflights offers flight deals from Des Moines to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to South America?

    Currently, February is the cheapest month in which you can book a flight from Des Moines to South America (average of $632). Flying from Des Moines to South America in April is currently the most expensive (average of $898). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to South America

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Top 4 airlines flying from Des Moines to South America

Discover the top 4 airlines that operate flights from Des Moines to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$566Average$585FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$571Average$978FlexibilityNo cancel feeOn-time81%
United AirlinesCheapest$585Average$706FlexibilityNo cancel feeOn-time69%
DeltaCheapest$709Average$1,173FlexibilityNo cancel feeOn-timeN/A

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