To save up to 16% on this flight, we recommend booking at least 52 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from Des Moines to Guayaquil from $469 1-2 weeks out and tickets from $477 for flights departing within the next 72 hours.
August can be a great time to fly to Guayaquil from Des Moines with a flight ticket averaging about $498. Cheapflights users have found deals in the month of August for as cheap as $186. The most expensive prices can be found in the month of January.
When flying from Des Moines to Guayaquil, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.