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$239+ Cheap flights from Guayaquil (GYE) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/27. Fares are subject to change and may not be available on all flights or dates of travel.
GYE — SCL
Jul 7 — Jul 141
Mon 7/7
Mon 7/14
1 adult, Economy
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Cheapflights Tip: The best prices from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez are usually found in October or November, booked 8 days in advance, depart on a Thursday or Sunday and return on a Monday

Cheap flight deals from Guayaquil to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Guayaquil (GYE) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 2, 2025.

Round-trip from

$457
(Copa Airlines)

One-way from

$239
(Copa Airlines)

Popular in

February

Cheapest in

October

Average price

$386

Good round-trip deal

$502 or less

Good one-way deal

$281 or less
From Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez
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One-way flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 7% potential increase in price ($31 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a round-trip flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez.
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Price to beat on a one-way flight from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez.
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Find flight deals from Guayaquil to Santiago

Cheapest flights from Guayaquil to Santiago
Explore the most affordable flight options available from Guayaquil to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

This Copa Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/276:05 amGYE - SCL
1 stop15h 39mCopa Airlines
Tue 9/24:11 amSCL - GYE
1 stop10h 35mCopa Airlines
Deal found 6/30$457
This Kiwi.com deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/126:32 pmGYE - SCL
1 stop27h 12mMultiple Airlines
Tue 8/192:30 pmSCL - GYE
1 stop9h 10mMultiple Airlines
Deal found 7/1$462
This Priceline deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/106:30 pmGYE - SCL
1 stop8h 45mAvianca
Wed 10/112:55 amSCL - GYE
1 stop14h 45mAvianca
Deal found 6/30$479
This FlightHub deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/232:45 pmGYE - SCL
Nonstop4h 53mLATAM Airlines
Tue 7/2911:50 pmSCL - GYE
Nonstop5h 23mLATAM Airlines
Deal found 6/30$508

Cheapflights Fare Finder

Customize your flight search to find flights from Guayaquil to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
Use the filters below to find and compare flights from Guayaquil to Santiago that are best for you.

Fly from

Guayaquil

Fly to

Santiago

Route

Depart

Return

Price

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Wed 8/27

6:05 am-11:08 pm

1 stop16h 03m

Santiago Arturo Merino Benitez

Mon 9/1

2:26 am-8:34 pm

1 stop19h 08m

$457

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Tue 8/12

6:32 pm-10:44 pm

1 stop27h 12m

Santiago Arturo Merino Benitez

Tue 8/19

2:30 pm-10:40 pm

1 stop9h 10m

$462

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Thu 7/10

6:30 pm-4:15 am

1 stop8h 45m

Santiago Arturo Merino Benitez

Wed 10/1

12:55 am-1:40 pm

1 stop14h 45m

$479

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Wed 7/23

2:45 pm-8:38 pm

Nonstop4h 53m

Santiago Arturo Merino Benitez

Tue 7/29

11:50 pm-4:13 am

Nonstop5h 23m

$508

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Wed 8/27

4:27 am-10:44 pm

1 stop17h 17m

$239

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Wed 7/30

2:45 pm-8:38 pm

Nonstop4h 53m

$269

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Sun 7/20

3:35 am-10:30 pm

1 stop17h 55m

$318

GuayaquilSantiago

GYE - SCL

GYESCL

Guayaquil Jose Joaquin de Olmedo

Sun 7/27

3:35 am-4:25 pm

2 stops11h 50m

$396

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Best time to book a flight from Guayaquil to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Guayaquil with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Guayaquil to Santiago

How far ahead should I book a flight from Guayaquil to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Guayaquil to Santiago. Price data was last updated on June 27, 2025.

To ensure you get the cheapest price possible for a flight from Guayaquil to Santiago, you should look to book at least 8 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Guayaquil to Santiago?

Currently, April is the cheapest month in which you can book a flight from Guayaquil to Santiago (average of $752). Flying from Guayaquil to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GYE to SCL?

Find hourly flight availability from Guayaquil to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 2, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 32% on flights from Guayaquil to Santiago by exploring options for tickets in the morning.

What is the cheapest day to fly from Guayaquil to Santiago?

Use this chart to determine the cheapest time to fly round-trip from Guayaquil to Santiago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Guayaquil to Santiago flight should consider departing on Sunday evenings when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Guayaquil to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated July 2, 2025.
Get a feel of what it's like to fly with LATAM Airlines, Copa Airlines, and Avianca from Guayaquil to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,805 reviews

Boarding

7.6

Food

6.7

Overall

7.5

Crew

8.1

Entertainment

7.0

Comfort

7.4

Reviews

1 / 20
10.0
Excellent

Anonymous,Mar 2025

COR - LIM

Always a great service. Better than Delta or American Airlines
LATAM Airlines
7.5
Good
1,805 reviews
LATAM Airlines
7.5
Good
1,805 reviews

Boarding

7.6

Food

6.7

Overall

7.5

Crew

8.1

Entertainment

7.0

Comfort

7.4

Reviews

1 / 20
10.0
Excellent

Anonymous,Mar 2025

COR - LIM

Always a great service. Better than Delta or American Airlines
Copa Airlines
7.5
Good
1,465 reviews
LATAM Airlines
7.5
Good
1,805 reviews

Boarding

7.6

Food

6.7

Overall

7.5

Crew

8.1

Entertainment

7.0

Comfort

7.4

Reviews

1 / 20
10.0
Excellent

Anonymous,Mar 2025

COR - LIM

Always a great service. Better than Delta or American Airlines
Avianca
6.7
Okay
2,363 reviews
LATAM Airlines
7.5
Good
1,805 reviews

Boarding

7.6

Food

6.7

Overall

7.5

Crew

8.1

Entertainment

7.0

Comfort

7.4

Reviews

1 / 20
10.0
Excellent

Anonymous,Mar 2025

COR - LIM

Always a great service. Better than Delta or American Airlines

Related info for your journey

Find useful and relevant information for your journey from Guayaquil to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Guayaquil to Santiago flight route?

    Flights from Guayaquil Jose Joaquin de Olmedo to Santiago Arturo Merino Benitez have been viewed 1 times in the past calendar month.

  • What are the cheapest airlines flying from Guayaquil to Santiago round-trip?

    Copa Airlines, at $457, was found to be the cheapest airline from Guayaquil to Santiago.Alternate airlines to your destination round-trip include Avianca and LATAM Airlines.

  • What are the cheapest airlines to fly from Guayaquil to Santiago one-way?

    The cheapest airlines for a one-way flight from Guayaquil to Santiago are Copa Airlines ($239), LATAM Airlines ($269), and Avianca ($318).

  • What are the cheapest flights from Guayaquil to Santiago?

    Looking at all options, your cheapest flight can be booked for $255. While the most popular route (Guayaquil Jose Joaquin de Olmedo - Santiago Arturo Merino Benitez) can be booked for $443 on average our data indicates $436 when flying from Guayaquil to Santiago.

  • Can I find deals for flights from Guayaquil to Santiago that include hotel bookings?

    Yes. In addition to deals on Guayaquil to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Guayaquil to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guayaquil to Santiago.

  • Can I find deals for business class flights from Guayaquil to Santiago?

    Yes. Cheapflights offers flight deals from Guayaquil to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Guayaquil to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Guayaquil to Santiago (average of $752). Flying from Guayaquil to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Guayaquil to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Quito to Santiago flights

Top 2 airlines flying from Guayaquil to Santiago

Discover the top 2 airlines that operate flights from Guayaquil to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$226Average$336FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$299Average$459FlexibilityNo cancel feeOn-time81%

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