$223+ Cheap flights from Quito (UIO) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/28. Fares are subject to change and may not be available on all flights or dates of travel.
UIO — SCL
Aug 23 — Aug 301
Round-trip
1 adult, Economy
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Cheapest flights from Quito to SantiagoExplore the most affordable flight options available from Quito to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 24, 2026.
Explore the most affordable flight options available from Quito to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 24, 2026.
This Justfly.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:48 pm
UIO
- SCL
1 stop10h 25m
JetSMART
Fri 9/185:57 am
SCL
- UIO
1 stop12h 06m
JetSMART
Deal found 7/24![JetSMART logo]()
$358
This Booking.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/214:49 pm
UIO
- SCL
1 stop10h 17m
JetSMART
Fri 8/284:56 am
SCL
- UIO
1 stop12h 08m
JetSMART
Deal found 7/24![JetSMART logo]()
$363
This JetSMART deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/284:49 pm
UIO
- SCL
1 stop10h 17m
JetSMART
Fri 9/185:57 am
SCL
- UIO
1 stop12h 06m
JetSMART
Deal found 7/24![JetSMART logo]()
$379
This JetSMART deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:48 pm
UIO
- SCL
1 stop10h 20m
JetSMART
Sun 11/16:07 am
SCL
- UIO
1 stop11h 57m
JetSMART
Deal found 7/24![JetSMART logo]()
$381
This Booking.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/234:50 pm
UIO
- SCL
1 stop10h 13m
JetSMART
Wed 11/256:07 am
SCL
- UIO
1 stop11h 57m
JetSMART
Deal found 7/24![JetSMART logo]()
$393
This Justfly.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:20 am
UIO
- SCL
1 stop15h 09m
LATAM Airlines
Wed 8/264:50 pm
SCL
- UIO
1 stop11h 25m
LATAM Airlines
Deal found 7/20![LATAM Airlines logo]()
$402
This Avianca deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1612:00 pm
UIO
- SCL
2 stops15h 45m
Avianca
Thu 9/244:20 pm
SCL
- UIO
1 stop18h 20m
Avianca
Deal found 7/22![Avianca logo]()
$404
This LATAM Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:38 pm
UIO
- SCL
2 stops19h 27m
LATAM Airlines
Wed 8/269:05 pm
SCL
- UIO
2 stops15h 00m
LATAM Airlines
Deal found 7/21![LATAM Airlines logo]()
$413
This LATAM Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:40 pm
UIO
- SCL
2 stops15h 42m
LATAM Airlines
Wed 11/185:55 pm
SCL
- UIO
1 stop10h 00m
LATAM Airlines
Deal found 7/21![LATAM Airlines logo]()
$416
This Copa Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:36 pm
UIO
- SCL
1 stop27h 43m
Copa Airlines
Sun 11/85:07 am
SCL
- UIO
1 stop20h 25m
Copa Airlines
Deal found 7/21![Copa Airlines logo]()
$417
Best flights from Quito to SantiagoDiscover carefully curated flight deals from Quito to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 24, 2026.
Discover carefully curated flight deals from Quito to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 24, 2026.
This JetSMART deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:49 pm
UIO
- SCL
1 stop10h 22m
JetSMART
Mon 10/195:56 am
SCL
- UIO
1 stop12h 08m
JetSMART
Deal found 7/24![JetSMART logo]()
$379
This Copa Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2312:25 pm
UIO
- SCL
1 stop9h 14m
Copa Airlines
Sun 9/2712:22 pm
SCL
- UIO
1 stop26h 08m
Copa Airlines
Deal found 7/22![Copa Airlines logo]()
$417
This Avianca deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:30 am
UIO
- SCL
2 stops15h 50m
Avianca
Fri 9/187:40 am
SCL
- UIO
2 stops12h 55m
Avianca
Deal found 7/22![Avianca logo]()
$423
This Justfly.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/288:20 pm
UIO
- SCL
1 stop16h 45m
LATAM Airlines
Sat 9/512:45 am
SCL
- UIO
1 stop15h 32m
LATAM Airlines
Deal found 7/21![LATAM Airlines logo]()
$474
This JetSMART deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/144:49 pm
UIO
- SCL
1 stop10h 27m
JetSMART
Sun 10/185:56 am
SCL
- UIO
1 stop12h 08m
JetSMART
Deal found 7/24![JetSMART logo]()
$417
This Copa Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:36 pm
UIO
- SCL
1 stop27h 43m
Copa Airlines
Sun 11/85:07 am
SCL
- UIO
1 stop20h 25m
Copa Airlines
Deal found 7/21![Copa Airlines logo]()
$417
This Copa Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3012:27 pm
UIO
- SCL
1 stop9h 55m
Copa Airlines
Sun 11/85:07 am
SCL
- UIO
1 stop21h 25m
Copa Airlines
Deal found 7/22![Copa Airlines logo]()
$417
This JetSMART deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:49 pm
UIO
- SCL
1 stop10h 22m
JetSMART
Wed 10/215:41 am
SCL
- UIO
1 stop12h 23m
JetSMART
Deal found 7/24![JetSMART logo]()
$419
This Copa Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:30 pm
UIO
- SCL
1 stop27h 13m
Copa Airlines
Fri 9/412:43 am
SCL
- UIO
1 stop14h 29m
Copa Airlines
Deal found 7/22![Copa Airlines logo]()
$445
This JetSMART deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/224:50 pm
UIO
- SCL
1 stop10h 13m
JetSMART
Fri 11/276:07 am
SCL
- UIO
1 stop11h 57m
JetSMART
Deal found 7/23![JetSMART logo]()
$484
This JetSMART deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:48 pm
UIO
- SCL
1 stop10h 20m
JetSMART
Sun 11/16:07 am
SCL
- UIO
1 stop11h 57m
JetSMART
Deal found 7/23![JetSMART logo]()
$490
Last-minute flights from Quito to SantiagoDiscover last-minute flight deals from Quito to Santiago. Data last updated July 24, 2026 and is based on user searches.
Discover last-minute flight deals from Quito to Santiago. Data last updated July 24, 2026 and is based on user searches.
This JetSMART deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/144:49 pm
UIO
- SCL
1 stop10h 17m
JetSMART
Fri 10/25:56 am
SCL
- UIO
1 stop12h 08m
JetSMART
Deal found 7/24![JetSMART logo]()
$432
This Justfly.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:20 am
UIO
- SCL
1 stop15h 09m
LATAM Airlines
Wed 8/264:50 pm
SCL
- UIO
1 stop11h 25m
LATAM Airlines
Deal found 7/20![LATAM Airlines logo]()
$402
This Avianca deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:30 am
UIO
- SCL
2 stops15h 50m
Avianca
Wed 8/266:40 am
SCL
- UIO
1 stop12h 00m
Avianca
Deal found 7/22![Avianca logo]()
$404
This LATAM Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:38 pm
UIO
- SCL
2 stops19h 27m
LATAM Airlines
Wed 8/269:05 pm
SCL
- UIO
2 stops15h 00m
LATAM Airlines
Deal found 7/21![LATAM Airlines logo]()
$413
This Avianca deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:45 am
UIO
- SCL
1 stop17h 35m
Avianca
Thu 8/276:40 am
SCL
- UIO
1 stop12h 00m
Avianca
Deal found 7/21![Avianca logo]()
$415
This Booking.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/214:49 pm
UIO
- SCL
1 stop10h 17m
JetSMART
Fri 8/284:56 am
SCL
- UIO
1 stop12h 08m
JetSMART
Deal found 7/24![JetSMART logo]()
$363
This Avianca deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:50 pm
UIO
- SCL
1 stop8h 55m
Avianca
Sat 8/296:40 am
SCL
- UIO
2 stops11h 35m
Avianca
Deal found 7/22![Avianca logo]()
$433
This JetSMART deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/284:49 pm
UIO
- SCL
1 stop10h 17m
JetSMART
Fri 9/185:57 am
SCL
- UIO
1 stop12h 06m
JetSMART
Deal found 7/24![JetSMART logo]()
$379
This Avianca deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:30 am
UIO
- SCL
2 stops15h 50m
Avianca
Sat 9/56:40 am
SCL
- UIO
2 stops15h 20m
Avianca
Deal found 7/22![Avianca logo]()
$423
This JetSMART deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetSMART is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/304:49 pm
UIO
- SCL
1 stop9h 57m
JetSMART
Mon 11/306:07 am
SCL
- UIO
1 stop11h 57m
JetSMART
Deal found 7/24![JetSMART logo]()
$417
One-way flights from Quito to SantiagoSearch for one-way flight options from Quito to Santiago. Find affordable one-way fares based on user searches. Data last updated July 24, 2026.
Search for one-way flight options from Quito to Santiago. Find affordable one-way fares based on user searches. Data last updated July 24, 2026.
This Avianca deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:30 am
UIO
- SCL
2 stops16h 00m
Avianca
Deal found 7/22![Avianca logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:47 am
UIO
- SCL
1 stop15h 42m
LATAM Airlines
Deal found 7/21![LATAM Airlines logo]()
$233
This FlightHub deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/1911:00 pm
UIO
- SCL
Nonstop5h 00m
LATAM Airlines
Deal found 7/22![LATAM Airlines logo]()
$234
This Copa Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:32 pm
UIO
- SCL
1 stop27h 46m
Copa Airlines
Deal found 7/22![Copa Airlines logo]()
$235
This FlightHub deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/157:40 pm
UIO
- SCL
2 stops12h 06m
LATAM Airlines
Deal found 7/22![LATAM Airlines logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/164:48 pm
UIO
- SCL
1 stop10h 25m
JetSMART
Deal found 7/23![JetSMART logo]()
$260
This FlightHub deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:55 am
UIO
- SCL
1 stop13h 00m
LATAM Airlines
Deal found 7/20![LATAM Airlines logo]()
$261
This Copa Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/183:08 am
UIO
- SCL
1 stop19h 15m
Copa Airlines
Deal found 7/22![Copa Airlines logo]()
$263
This Booking.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/214:49 pm
UIO
- SCL
1 stop10h 17m
JetSMART
Deal found 7/23![JetSMART logo]()
$264
This Booking.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/234:49 pm
UIO
- SCL
1 stop10h 27m
JetSMART
Deal found 7/20![JetSMART logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/153:35 pm
UIO
- SCL
2 stops12h 15m
LATAM Airlines
Deal found 7/23![LATAM Airlines logo]()
$271
This Booking.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/184:49 pm
UIO
- SCL
1 stop10h 25m
JetSMART
Deal found 7/22![JetSMART logo]()
$273
Find flight deals from Quito to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from Quito (UIO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $379 (JetSMART) |
One-way from | $223 (Avianca) |
Popular in | February |
Cheapest in | June |
Average price | $448 |
Cheapflights Fare Finder
Customize your flight search to find flights from Quito to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 24, 2026.
Use the filters below to find and compare flights from Quito to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
QuitoSantiago
UIO - SCL
UIOSCL
Quito Mariscal Sucr
Fri 10/16
4:49 pm-5:11 am
1 stop10h 22m
Santiago Arturo Merino Benitez
Mon 10/19
5:56 am-4:04 pm
1 stop12h 08m
$379
QuitoSantiago
UIO - SCL
UIOSCL
Quito Mariscal Sucr
Wed 9/23
12:25 pm-11:39 pm
1 stop9h 14m
Santiago Arturo Merino Benitez
Sun 9/27
12:22 pm-12:30 pm
1 stop26h 08m
$417
QuitoSantiago
UIO - SCL
UIOSCL
Quito Mariscal Sucr
Wed 10/14
4:49 pm-5:16 am
1 stop10h 27m
Santiago Arturo Merino Benitez
Sun 10/18
5:56 am-4:04 pm
1 stop12h 08m
$417
QuitoSantiago
UIO - SCL
UIOSCL
Quito Mariscal Sucr
Sun 11/1
6:36 pm-12:19 am
1 stop27h 43m
Santiago Arturo Merino Benitez
Sun 11/8
5:07 am-11:32 pm
1 stop20h 25m
$417
QuitoSantiago
UIO - SCL
UIOSCL
Quito Mariscal Sucr
Fri 10/30
12:27 pm-12:22 am
1 stop9h 55m
Santiago Arturo Merino Benitez
Sun 11/8
5:07 am-12:32 am
1 stop21h 25m
$417
QuitoSantiago
UIO - SCL
UIOSCL
Quito Mariscal Sucr
Fri 10/16
4:49 pm-5:11 am
1 stop10h 22m
Santiago Arturo Merino Benitez
Wed 10/21
5:41 am-4:04 pm
1 stop12h 23m
$419
QuitoSantiago
UIO - SCL
UIOSCL
Quito Mariscal Sucr
Tue 9/8
6:30 am-12:20 am
2 stops15h 50m
Santiago Arturo Merino Benitez
Fri 9/18
7:40 am-6:35 pm
2 stops12h 55m
$423
QuitoSantiago
UIO - SCL
UIOSCL
Quito Mariscal Sucr
Sat 8/29
6:30 pm-10:43 pm
1 stop27h 13m
Santiago Arturo Merino Benitez
Fri 9/4
12:43 am-2:12 pm
1 stop14h 29m
$445
QuitoSantiago
UIO - SCL
UIOSCL
Quito Mariscal Sucr
Fri 8/28
8:20 pm-2:05 pm
1 stop16h 45m
Santiago Arturo Merino Benitez
Sat 9/5
12:45 am-3:17 pm
1 stop15h 32m
$474
Quickest round-trip
QuitoSantiago
UIO - SCL
UIOSCL
Quito Mariscal Sucr
Sun 11/22
4:50 pm-5:03 am
1 stop10h 13m
Santiago Arturo Merino Benitez
Fri 11/27
6:07 am-4:04 pm
1 stop11h 57m
$484
Showing 1-10 of 20 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Quito-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Quito-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Quito-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Quito-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Quito-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Quito to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Quito with our price prediction graph.
UIO-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Quito to Santiago
How far ahead should I book a flight from Quito to Santiago?
The price you pay for your flight from Quito to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 58 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Quito to Santiago?
Currently, June is the cheapest month in which you can book a flight from Quito to Santiago (average of $359). Flying from Quito to Santiago in February is currently the most expensive (average of $523). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Quito to Santiago?
Airfare is typical for this route at the moment.
Quito to Santiago flights typically cost between $304 and $559 in August.The cheapest round-trip price found within the last 5 days was $379 on JetSMART (Aug 28-Sep 18).
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated July 24, 2026.
Read reviews from past customers who have flown Copa Airlines,LATAM Airlines, andJetSMART from Quito to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.9
Boarding
7.8
Comfort
7.4
Overall
7.6
Entertainment
6.8
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Food
6.9
Boarding
7.8
Comfort
7.4
Overall
7.6
Entertainment
6.8
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Food
6.9
Boarding
7.8
Comfort
7.4
Overall
7.6
Entertainment
6.8
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Food
6.9
Boarding
7.8
Comfort
7.4
Overall
7.6
Entertainment
6.8
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Food
6.9
Boarding
7.8
Comfort
7.4
Overall
7.6
Entertainment
6.8
Crew
8.1
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Quito to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Find flights from Quito to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Quito and Santiago flights
Browse other Quito and Santiago flight options. Last updated on July 24, 2026.
Other flights from Quito
Browse through other flights departing from Quito. Flights are based on user searches made on Cheapflights and were last updated on July 24, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 24, 2026.
Top 4 airlines flying from Quito to Santiago
Discover the top 4 airlines that operate flights from Quito to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$166 | Average$390 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$194 | Average$548 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$275 | Average$528 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$341 | Average$574 | FlexibilityNo cancel fee | On-time81% |