$293+ Cheap flights from Guayaquil (GYE) to Santo Domingo (SDQ)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.
GYE — SDQ
Nov 19 — Nov 261
Round-trip
1 adult, Economy
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Find cheap flights from Guayaquil to Santo Domingo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Guayaquil to Santo Domingo
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Cheapest flights from Guayaquil to Santo DomingoExplore the most affordable flight options available from Guayaquil to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
Explore the most affordable flight options available from Guayaquil to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
This Copa Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/22:47 pm -
1 stop24h 25m
Mon 11/97:06 pm -
1 stop23h 29m
Deal found 10/15![Copa Airlines logo]()
$422
This Justfly.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1810:10 am -
1 stop6h 40m
Wed 11/256:45 pm -
2 stops18h 00m
Deal found 10/19![Avianca logo]()
$431
This Avianca deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/23:30 am -
1 stop13h 20m
Tue 11/1712:45 pm -
1 stop6h 40m
Deal found 10/17![Avianca logo]()
$438
This Avianca deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1810:10 am -
1 stop6h 40m
Mon 11/2312:45 pm -
2 stops8h 45m
Deal found 10/16![Avianca logo]()
$439
This Avianca deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:55 pm -
2 stops14h 55m
Wed 11/116:45 pm -
2 stops13h 40m
Deal found 10/19![Avianca logo]()
$441
This Copa Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/122:47 pm -
1 stop24h 25m
Thu 11/1912:10 pm -
1 stop6h 25m
Deal found 10/18![Copa Airlines logo]()
$444
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:34 pm -
1 stop6h 34m
Wed 12/1612:43 pm -
1 stop9h 14m
Deal found 10/20![Copa Airlines logo]()
$448
This Arajet deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Arajet is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/212:55 am -
1 stop8h 45m
Fri 1/86:00 pm -
1 stop8h 20m
Deal found 10/19![Multiple Airlines logo]()
$450
This Avianca deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:30 am -
2 stops10h 20m
Wed 11/186:45 pm -
1 stop15h 15m
Deal found 10/20![Avianca logo]()
$452
This Avianca deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:30 am -
1 stop7h 20m
Sun 11/16:45 pm -
1 stop15h 15m
Deal found 10/17![Avianca logo]()
$456
This Avianca deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2810:10 am -
1 stop6h 40m
Sat 12/56:45 pm -
2 stops15h 10m
Deal found 10/18![Avianca logo]()
$458
This FlightHub deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:10 am -
1 stop24h 40m
Thu 11/2612:45 pm -
2 stops21h 25m
Deal found 10/19![Avianca logo]()
$463
Best flights from Guayaquil to Santo DomingoDiscover carefully curated flight deals from Guayaquil to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
Discover carefully curated flight deals from Guayaquil to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
This Copa Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/234:22 am -
1 stop5h 40m
Thu 12/3112:09 pm -
1 stop12h 49m
Deal found 10/15![Copa Airlines logo]()
$422
This Copa Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/146:34 pm -
1 stop6h 34m
Mon 12/218:55 am -
1 stop13h 02m
Deal found 10/18![Copa Airlines logo]()
$422
This Copa Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/912:25 pm -
1 stop12h 43m
Mon 11/1612:45 pm -
1 stop23h 33m
Deal found 10/17![Copa Airlines logo]()
$422
This Copa Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:38 pm -
1 stop20h 34m
Mon 11/2312:45 pm -
1 stop5h 50m
Deal found 10/16![Copa Airlines logo]()
$422
This Copa Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/912:21 pm -
1 stop21h 41m
Tue 2/165:53 am -
1 stop6h 27m
Deal found 10/15![Copa Airlines logo]()
$422
This Copa Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/124:22 am -
1 stop20h 42m
Sat 2/208:54 am -
1 stop5h 49m
Deal found 10/19![Copa Airlines logo]()
$422
This Copa Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/84:22 am -
1 stop10h 51m
Sat 12/1912:09 pm -
1 stop24h 13m
Deal found 10/19![Copa Airlines logo]()
$422
This Copa Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:38 pm -
1 stop16h 07m
Tue 11/1712:10 pm -
1 stop6h 25m
Deal found 10/16![Copa Airlines logo]()
$422
This Copa Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:25 am -
1 stop6h 47m
Tue 11/247:06 pm -
1 stop17h 12m
Deal found 10/19![Copa Airlines logo]()
$422
This Copa Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/178:25 am -
1 stop6h 48m
Thu 12/245:53 am -
1 stop16h 04m
Deal found 10/18![Copa Airlines logo]()
$422
This Copa Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/65:54 am -
1 stop6h 14m
Wed 1/132:19 pm -
1 stop24h 25m
Deal found 10/18![Copa Airlines logo]()
$422
Last-minute flights from Guayaquil to Santo DomingoDiscover last-minute flight deals from Guayaquil to Santo Domingo. Data last updated October 20, 2026 and is based on user searches.
Discover last-minute flight deals from Guayaquil to Santo Domingo. Data last updated October 20, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/243:30 am -
1 stop7h 20m
Sun 11/16:45 pm -
1 stop15h 15m
Deal found 10/17![Avianca logo]()
$456
This Copa Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/22:47 pm -
1 stop24h 25m
Mon 11/97:06 pm -
1 stop23h 29m
Deal found 10/15![Copa Airlines logo]()
$422
This Avianca deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/23:30 am -
1 stop13h 20m
Tue 11/1712:45 pm -
1 stop6h 40m
Deal found 10/17![Avianca logo]()
$438
This Avianca deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:55 pm -
2 stops14h 55m
Wed 11/116:45 pm -
2 stops13h 40m
Deal found 10/19![Avianca logo]()
$441
This Avianca deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:30 am -
2 stops10h 20m
Tue 11/1712:45 pm -
1 stop11h 50m
Deal found 10/15![Avianca logo]()
$468
This Avianca deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:30 am -
2 stops10h 20m
Wed 11/186:45 pm -
1 stop15h 15m
Deal found 10/20![Avianca logo]()
$452
This Copa Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/122:47 pm -
1 stop24h 25m
Thu 11/1912:10 pm -
1 stop6h 25m
Deal found 10/18![Copa Airlines logo]()
$444
This Justfly.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1810:10 am -
1 stop6h 40m
Wed 11/256:45 pm -
2 stops18h 00m
Deal found 10/19![Avianca logo]()
$431
This Avianca deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1810:10 am -
1 stop6h 40m
Mon 11/2312:45 pm -
2 stops8h 45m
Deal found 10/16![Avianca logo]()
$439
This FlightHub deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:10 am -
1 stop24h 40m
Thu 11/2612:45 pm -
2 stops21h 25m
Deal found 10/19![Avianca logo]()
$463
This Avianca deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2810:10 am -
1 stop6h 40m
Sat 12/56:45 pm -
2 stops15h 10m
Deal found 10/18![Avianca logo]()
$458
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/308:25 am -
1 stop6h 47m
Mon 12/712:43 pm -
1 stop5h 53m
Deal found 10/18![Copa Airlines logo]()
$464
One-way flights from Guayaquil to Santo DomingoSearch for one-way flight options from Guayaquil to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
Search for one-way flight options from Guayaquil to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
This Avianca deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:35 pm -
1 stop15h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Avianca logo]()
$293
This Avianca deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/157:35 pm -
1 stop15h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Avianca logo]()
$295
This Copa Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/118:26 am -
1 stop13h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Copa Airlines logo]()
$309
This Avianca deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/66:15 pm -
2 stops16h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Avianca logo]()
$359
This Copa Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2012:22 pm -
1 stop22h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![Copa Airlines logo]()
$366
This Avianca deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/205:55 pm -
2 stops16h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![Avianca logo]()
$438
This JetBlue deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/272:30 pm -
1 stop9h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![JetBlue logo]()
$507
This Travelocity deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:15 pm -
2 stops46h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![Avianca logo]()
$534
This Booking.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:15 pm -
3 stops15h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![Multiple Airlines logo]()
$626
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/193:30 pm -
3 stops29h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![Multiple Airlines logo]()
$682
Find flight deals from Guayaquil to Santo Domingo
Discover tips and strategies to find the most affordable flight options for your journey from Guayaquil (GYE) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $422 (Copa Airlines) |
One-way from | $293 (Avianca) |
Popular in | December |
Cheapest in | November |
Average price | $461 |
Cheapflights Fare Finder
Customize your flight search to find flights from Guayaquil to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
Use the filters below to find and compare flights from Guayaquil to Santo Domingo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GuayaquilSanto Domingo
GYE Guayaquil Jose Joaquin de Olmedo - SDQ Santo Domingo Las Americas
GYESDQ
Guayaquil Jose Joaquin de Olmedo
Sat 11/14
7:35 pm-11:50 am
1 stop15h 15m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$293
Quickest round-trip
GuayaquilSanto Domingo
GYE Guayaquil Jose Joaquin de Olmedo - SDQ Santo Domingo Las Americas
GYESDQ
Guayaquil Jose Joaquin de Olmedo
Sat 11/7
9:10 am-5:50 pm
1 stop7h 40m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$293
GuayaquilSanto Domingo
GYE Guayaquil Jose Joaquin de Olmedo - SDQ Santo Domingo Las Americas
GYESDQ
Guayaquil Jose Joaquin de Olmedo
Mon 2/15
7:35 pm-11:50 am
1 stop15h 15m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$295
GuayaquilSanto Domingo
GYE Guayaquil Jose Joaquin de Olmedo - SDQ Santo Domingo Las Americas
GYESDQ
Guayaquil Jose Joaquin de Olmedo
Fri 12/18
4:22 am-2:08 am
1 stop20h 46m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$309
GuayaquilSanto Domingo
GYE Guayaquil Jose Joaquin de Olmedo - SDQ Santo Domingo Las Americas
GYESDQ
Guayaquil Jose Joaquin de Olmedo
Sat 11/14
12:25 pm-2:08 am
1 stop12h 43m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$309
GuayaquilSanto Domingo
GYE Guayaquil Jose Joaquin de Olmedo - SDQ Santo Domingo Las Americas
GYESDQ
Guayaquil Jose Joaquin de Olmedo
Fri 11/27
2:47 pm-11:07 am
1 stop19h 20m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$309
GuayaquilSanto Domingo
GYE Guayaquil Jose Joaquin de Olmedo - SDQ Santo Domingo Las Americas
GYESDQ
Guayaquil Jose Joaquin de Olmedo
Mon 12/7
2:45 pm-1:14 pm
1 stop21h 29m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$309
GuayaquilSanto Domingo
GYE Guayaquil Jose Joaquin de Olmedo - SDQ Santo Domingo Las Americas
GYESDQ
Guayaquil Jose Joaquin de Olmedo
Wed 10/28
6:01 am-10:56 pm
1 stop15h 55m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$309
GuayaquilSanto Domingo
GYE Guayaquil Jose Joaquin de Olmedo - SDQ Santo Domingo Las Americas
GYESDQ
Guayaquil Jose Joaquin de Olmedo
Thu 2/11
8:26 am-10:56 pm
1 stop13h 30m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$309
GuayaquilSanto Domingo
GYE Guayaquil Jose Joaquin de Olmedo - SDQ Santo Domingo Las Americas
GYESDQ
Guayaquil Jose Joaquin de Olmedo
Wed 12/23
4:22 am-11:02 am
1 stop5h 40m
Santo Domingo Las Americas
Thu 12/31
12:09 pm-11:58 pm
1 stop12h 49m
$422
Showing 1-10 of 20 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Guayaquil-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Guayaquil-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Guayaquil-Santo Domingo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Guayaquil-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Guayaquil-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Guayaquil to Santo Domingo
Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Guayaquil with our price prediction graph.
GYE-SDQ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Guayaquil to Santo Domingo
How far ahead should I book a flight from Guayaquil to Santo Domingo?
To ensure you get the cheapest price possible for a flight from Guayaquil to Santo Domingo, you should look to book at least 60 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Guayaquil to Santo Domingo?
Currently, November is the cheapest month in which you can book a flight from Guayaquil to Santo Domingo (average of $436). Flying from Guayaquil to Santo Domingo in December is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Guayaquil to Santo Domingo?
Airfare is below average for this route at the moment.
Guayaquil to Santo Domingo flights typically cost between $426 and $495 in November.The cheapest round-trip price found within the last 5 days was $422 on Copa Airlines (Nov 2-Nov 9).
Reviews of airlines servicing Santo Domingo
Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated October 20, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Guayaquil to Santo Domingo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.5
Entertainment
6.9
Food
7.0
Boarding
7.8
Overall
7.6
Crew
8.1
Reviews
1 / 20
4.0
OkayAnonymous,Mar 2025
PTY - JFK
Comfort
7.5
Entertainment
6.9
Food
7.0
Boarding
7.8
Overall
7.6
Crew
8.1
Reviews
1 / 20
4.0
OkayAnonymous,Mar 2025
PTY - JFK
Comfort
7.5
Entertainment
6.9
Food
7.0
Boarding
7.8
Overall
7.6
Crew
8.1
Reviews
1 / 20
4.0
OkayAnonymous,Mar 2025
PTY - JFK
Related info for your journey
Find useful and relevant information for your journey from Guayaquil to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santo Domingo?
Book flights to Santo Domingo if you plan to visit one of these locationsJuan Dolio
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Guayaquil and Santo Domingo flights
Browse other Guayaquil and Santo Domingo flight options. Last updated on October 20, 2026.
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Other flights to Santo Domingo
Explore flights to Santo Domingo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 20, 2026.
Top 2 airlines flying from Guayaquil to Santo Domingo
Discover the top 2 airlines that operate flights from Guayaquil to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$383 | Average$470 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$414 | Average$493 | FlexibilityNo cancel fee | On-time71% |