What are the cheapest airlines flying from Des Moines to Santiago round-trip?

Currently priced at $874, United Airlines will fly you from Des Moines to Santiago and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and American Airlines - these airlines can fly you to your destination from $910 and $989, respectively. United Airlines is 17% cheaper than the average price of flights available within the next 90 days to this destination.

What is the cheapest month to book a flight from Des Moines to Santiago?

Currently, April is the cheapest month in which you can book a flight from Des Moines to Santiago (average of $752). Flying from Des Moines to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest day to fly from Des Moines to Santiago?

Travelers seeking maximum savings on their Des Moines to Santiago flight should consider departing on Tuesday at noon when fares are most often at their lowest. Thursday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

What is the cheapest day to fly round-trip from Des Moines to Santiago?

Travelers have found that booking a Monday departure is the best way to save up to 76% on the cost of booking your flights compared to booking on days of the week where this route is of high demand.

What is the cheapest month to fly from Des Moines to Santiago?

October can be a great time to fly to Santiago from Des Moines with a flight ticket averaging about $1,065. Cheapflights users have found deals in the month of October for as cheap as $766. The most expensive prices can be found in the month of December.

What is the cheapest time of day to fly from DSM to SCL?

Unlike in the morning, when flights are generally more expensive, you can save up to 29% on flights from Des Moines to Santiago by exploring options for tickets in the afternoon.

Can I find deals for flights from Des Moines to Santiago that include hotel bookings?

Yes. In addition to deals on Des Moines to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Santiago?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santiago.

Can I find deals for business class flights from Des Moines to Santiago?

Yes. Cheapflights offers flight deals from Des Moines to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$496+ Flights from Des Moines to Santiago

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Cheap flight deals from Des Moines to Santiago

Round-trip from	$874 (United Airlines)
One-way from	$496 (Kiwi.com)
Popular in	December
Cheapest in	October
Average price	$1,118

From Des Moines to Santiago Arturo Merino Benitez

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One-way flight from Des Moines to Santiago Arturo Merino Benitez

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Highest demand for flights based on searches. 9% potential increase in price ($107 potential increase over avg. RT price).

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Cheapest flight prices on average. 4% potential price decrease ($48 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Des Moines to Santiago

Cheapest flights from Des Moines to Santiago
Explore the most affordable flight options available from Des Moines to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 7, 2025.

dom. 11/236:50 pmDSM - SCL

2 stops35h 00mUnited Airlines

mié. 11/2610:45 pmSCL - DSM

2 stops25h 47mUnited Airlines

Deal found 7/7

$874

lun. 12/85:45 amDSM - SCL

2 stops21h 55mDelta

vie. 12/128:50 pmSCL - DSM

2 stops16h 28mDelta

Deal found 7/6

$910

jue. 8/217:32 amDSM - SCL

2 stops22h 23mAmerican Airlines

jue. 8/289:55 pmSCL - DSM

2 stops21h 45mAmerican Airlines

Deal found 7/7

$989

lun. 12/82:14 pmDSM - SCL

1 stop13h 46mLATAM Airlines

jue. 12/1112:25 amSCL - DSM

2 stops20h 14mLATAM Airlines

Deal found 7/5

$1,027

jue. 8/217:15 pmDSM - SCL

3 stops33h 25mMultiple Airlines

jue. 8/286:10 amSCL - DSM

3 stops38h 59mMultiple Airlines

Deal found 7/7

$1,055

Best flights from Des Moines to Santiago
Discover carefully curated flight deals from Des Moines to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated julio 7, 2025.

dom. 11/236:50 pmDSM - SCL

2 stops35h 00mUnited Airlines

mié. 11/2610:45 pmSCL - DSM

2 stops25h 47mUnited Airlines

Deal found 7/7

$874

lun. 12/85:45 amDSM - SCL

2 stops21h 55mDelta

vie. 12/128:50 pmSCL - DSM

2 stops16h 28mDelta

Deal found 7/6

$910

jue. 8/217:32 amDSM - SCL

2 stops22h 23mAmerican Airlines

jue. 8/289:55 pmSCL - DSM

2 stops21h 45mAmerican Airlines

Deal found 7/7

$989

lun. 12/82:14 pmDSM - SCL

1 stop13h 46mLATAM Airlines

jue. 12/1112:25 amSCL - DSM

2 stops20h 14mLATAM Airlines

Deal found 7/5

$1,027

jue. 8/217:15 pmDSM - SCL

3 stops33h 25mMultiple Airlines

jue. 8/286:10 amSCL - DSM

3 stops38h 59mMultiple Airlines

Deal found 7/7

$1,055

Last-minute flights from Des Moines to Santiago
Discover last-minute flight deals from Des Moines to Santiago. Data last updated julio 7, 2025 and is based on user searches.

lun. 7/1410:03 amDSM - SCL

2 stops44h 17mIberia

vie. 7/254:15 pmSCL - DSM

2 stops32h 29mIberia

Deal found 7/7

$3,614

mar. 7/158:00 amDSM - SCL

2 stops19h 15mAvianca

mié. 7/236:10 amSCL - DSM

2 stops40h 37mAvianca

Deal found 7/7

$1,622

mié. 7/1610:03 amDSM - SCL

2 stops20h 02mAmerican Airlines

mié. 7/239:50 pmSCL - DSM

2 stops16h 48mAmerican Airlines

Deal found 7/7

$1,258

jue. 7/172:29 pmDSM - SCL

1 stop15h 31mDelta

lun. 7/218:40 pmSCL - DSM

1 stop17h 59mDelta

Deal found 7/7

$1,264

jue. 7/172:29 pmDSM - SCL

2 stops15h 01mLATAM Airlines

jue. 7/2411:05 pmSCL - DSM

2 stops19h 50mLATAM Airlines

Deal found 7/7

$1,273

lun. 8/1111:23 amDSM - SCL

1 stop18h 37mDelta

lun. 8/188:40 pmSCL - DSM

1 stop14h 58mDelta

Deal found 7/7

$1,104

mié. 8/202:12 pmDSM - SCL

1 stop15h 48mLATAM Airlines

mié. 8/274:55 pmSCL - DSM

2 stops18h 43mLATAM Airlines

Deal found 7/6

$1,103

jue. 8/217:32 amDSM - SCL

2 stops22h 23mAmerican Airlines

jue. 8/289:55 pmSCL - DSM

2 stops21h 45mAmerican Airlines

Deal found 7/7

$989

jue. 8/217:15 pmDSM - SCL

3 stops33h 25mMultiple Airlines

jue. 8/286:10 amSCL - DSM

3 stops38h 59mMultiple Airlines

Deal found 7/7

$1,055

One-way flights from Des Moines to Santiago
Search for one-way flight options from Des Moines to Santiago. Find affordable one-way fares based on user searches. Data last updated julio 7, 2025.

dom. 11/231:29 pmDSM - SCL

3 stops46h 11mMultiple Airlines

Deal found 7/7

$496

dom. 11/236:50 pmDSM - SCL

2 stops35h 00mUnited Airlines

Deal found 7/7

$549

dom. 11/232:14 pmDSM - SCL

1 stop13h 46mDelta

Deal found 7/7

$583

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

dom. 11/23

6:50 pm-8:50 am

2 stops35h 00m

Santiago Arturo Merino Benitez

mié. 11/26

10:45 pm-9:32 pm

2 stops25h 47m

$874

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

lun. 12/8

5:45 am-6:40 am

2 stops21h 55m

Santiago Arturo Merino Benitez

vie. 12/12

8:50 pm-10:18 am

2 stops16h 28m

$910

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

jue. 8/21

7:32 am-6:55 am

2 stops22h 23m

Santiago Arturo Merino Benitez

jue. 8/28

9:55 pm-6:40 pm

2 stops21h 45m

$989

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

lun. 12/8

2:14 pm-7:00 am

1 stop13h 46m

Santiago Arturo Merino Benitez

jue. 12/11

12:25 am-5:39 pm

2 stops20h 14m

$1,027

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

jue. 8/21

7:15 pm-5:40 am

3 stops33h 25m

Santiago Arturo Merino Benitez

jue. 8/28

6:10 am-8:09 pm

3 stops38h 59m

$1,055

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

dom. 11/23

1:29 pm-2:40 pm

3 stops46h 11m

$496

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

dom. 11/23

6:50 pm-8:50 am

2 stops35h 00m

$549

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

dom. 11/23

2:14 pm-7:00 am

1 stop13h 46m

$583

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/7

Best time to book a flight from Des Moines to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santiago

How much does it cost to fly round-trip from Des Moines to Santiago?

Reviews of airlines servicing Santiago

Read through reviews of airlines operating flights from Des Moines to Santiago, such as Delta, LATAM Airlines, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,962 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,962 reviews

Delta

8.0

Very good

7,962 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

LATAM Airlines

7.5

Good

1,804 reviews

Delta

8.0

Very good

7,962 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,844 reviews

Delta

8.0

Very good

7,962 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,962 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from Des Moines to Santiago round-trip?
Currently priced at $874, United Airlines will fly you from Des Moines to Santiago and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and American Airlines - these airlines can fly you to your destination from $910 and $989, respectively. United Airlines is 17% cheaper than the average price of flights available within the next 90 days to this destination.
Can I find deals for flights from Des Moines to Santiago that include hotel bookings?
Yes. In addition to deals on Des Moines to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Santiago?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santiago.
Can I find deals for business class flights from Des Moines to Santiago?
Yes. Cheapflights offers flight deals from Des Moines to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Santiago?
Currently, April is the cheapest month in which you can book a flight from Des Moines to Santiago (average of $752). Flying from Des Moines to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Des Moines to Santiago

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Other flights to Santiago

Top 2 airlines flying from Des Moines to Santiago

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$742	Average$1,558	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$782	Average$932	FlexibilityNo cancel fee	On-timeN/A

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$496+ Cheap flights from Des Moines (DSM) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Santiago with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to Santiago

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to Santiago

Cheapest flights from Des Moines to SantiagoExplore the most affordable flight options available from Des Moines to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 7, 2025.

Explore the most affordable flight options available from Des Moines to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 7, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Santiago that are best for you.

Best time to book a flight from Des Moines to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santiago

How much does it cost to fly round-trip from Des Moines to Santiago?

Reviews of airlines servicing Santiago

Read through reviews of airlines operating flights from Des Moines to Santiago, such as Delta, LATAM Airlines, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Des Moines to Santiago round-trip?

Can I find deals for flights from Des Moines to Santiago that include hotel bookings?

How can I find direct flights from Des Moines to Santiago?

Can I find deals for business class flights from Des Moines to Santiago?

What is the cheapest month to book a flight from Des Moines to Santiago?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Santiago

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Des Moines to Santiago

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Des Moines to Santiago
Explore the most affordable flight options available from Des Moines to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 7, 2025.