Santiago

$496+ Cheap flights from Des Moines (DSM) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SCL
jul. 12 — jul. 191
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Cheap flight deals from Des Moines to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated julio 7, 2025.

Round-trip from

$874
(United Airlines)

One-way from

$496
(Kiwi.com)

Popular in

December

Cheapest in

October

Average price

$1,118
From Des Moines to Santiago Arturo Merino Benitez
One-way flight from Des Moines to Santiago Arturo Merino Benitez
Highest demand for flights based on searches. 9% potential increase in price ($107 potential increase over avg. RT price).
Cheapest flight prices on average. 4% potential price decrease ($48 potential savings vs. average RT price).
Average for round-trip flights in July 2025

Find flight deals from Des Moines to Santiago

Cheapest flights from Des Moines to Santiago
Explore the most affordable flight options available from Des Moines to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 7, 2025.

This United Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/236:50 pmDSM - SCL
2 stops35h 00mUnited Airlines
mié. 11/2610:45 pmSCL - DSM
2 stops25h 47mUnited Airlines
Deal found 7/7$874
This Delta deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/85:45 amDSM - SCL
2 stops21h 55mDelta
vie. 12/128:50 pmSCL - DSM
2 stops16h 28mDelta
Deal found 7/6$910
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/217:32 amDSM - SCL
2 stops22h 23mAmerican Airlines
jue. 8/289:55 pmSCL - DSM
2 stops21h 45mAmerican Airlines
Deal found 7/7$989
This LATAM Airlines deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/82:14 pmDSM - SCL
1 stop13h 46mLATAM Airlines
jue. 12/1112:25 amSCL - DSM
2 stops20h 14mLATAM Airlines
Deal found 7/5$1,027
This Mytrip deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/217:15 pmDSM - SCL
3 stops33h 25mMultiple Airlines
jue. 8/286:10 amSCL - DSM
3 stops38h 59mMultiple Airlines
Deal found 7/7$1,055

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 7, 2025.
Use the filters below to find and compare flights from Des Moines to Santiago that are best for you.

Fly from

Des Moines

Fly to

Santiago

Route

Depart

Return

Price

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

dom. 11/23

6:50 pm-8:50 am

2 stops35h 00m

Santiago Arturo Merino Benitez

mié. 11/26

10:45 pm-9:32 pm

2 stops25h 47m

$874

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

lun. 12/8

5:45 am-6:40 am

2 stops21h 55m

Santiago Arturo Merino Benitez

vie. 12/12

8:50 pm-10:18 am

2 stops16h 28m

$910

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

jue. 8/21

7:32 am-6:55 am

2 stops22h 23m

Santiago Arturo Merino Benitez

jue. 8/28

9:55 pm-6:40 pm

2 stops21h 45m

$989

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

lun. 12/8

2:14 pm-7:00 am

1 stop13h 46m

Santiago Arturo Merino Benitez

jue. 12/11

12:25 am-5:39 pm

2 stops20h 14m

$1,027

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

jue. 8/21

7:15 pm-5:40 am

3 stops33h 25m

Santiago Arturo Merino Benitez

jue. 8/28

6:10 am-8:09 pm

3 stops38h 59m

$1,055

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

dom. 11/23

1:29 pm-2:40 pm

3 stops46h 11m

$496

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

dom. 11/23

6:50 pm-8:50 am

2 stops35h 00m

$549

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

dom. 11/23

2:14 pm-7:00 am

1 stop13h 46m

$583

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/7

Best time to book a flight from Des Moines to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santiago

How much does it cost to fly round-trip from Des Moines to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated julio 7, 2025.
Read through reviews of airlines operating flights from Des Moines to Santiago, such as Delta, LATAM Airlines, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
8.0
Very good

Boarding

8.2

Overall

8.0

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
8.0
Very good
8.0
Very good

Boarding

8.2

Overall

8.0

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
8.0
Very good

Boarding

8.2

Overall

8.0

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
8.0
Very good

Boarding

8.2

Overall

8.0

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
8.0
Very good

Boarding

8.2

Overall

8.0

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What are the cheapest airlines flying from Des Moines to Santiago round-trip?

    Currently priced at $874, United Airlines will fly you from Des Moines to Santiago and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and American Airlines - these airlines can fly you to your destination from $910 and $989, respectively. United Airlines is 17% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Santiago that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santiago.

  • Can I find deals for business class flights from Des Moines to Santiago?

    Yes. Cheapflights offers flight deals from Des Moines to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Des Moines to Santiago (average of $752). Flying from Des Moines to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Santiago

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Des Moines to Santiago

Discover the top 2 airlines that operate flights from Des Moines to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 7, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$742Average$1,558FlexibilityNo cancel feeOn-time71%
DeltaCheapest$782Average$932FlexibilityNo cancel feeOn-timeN/A

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