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$457+ Cheap flights from Des Moines (DSM) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/6. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SCL
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
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Cheap flight deals from Des Moines to Santiago

Cheapest flights from Des Moines to Santiago
Explore the most affordable flight options available from Des Moines to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:30 pm
DSM
-
SCL
2 stops21h 55m
Delta
Thu 8/208:40 pm
SCL
-
DSM
1 stop22h 02m
Delta
Deal found 1/20$825
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:30 pm
DSM
-
SCL
2 stops24h 15m
Delta
Mon 8/1711:00 pm
SCL
-
DSM
2 stops18h 49m
Delta
Deal found 1/20$830
This KAYAK deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/22:59 pm
DSM
-
SCL
1 stop14h 51m
Avianca
Tue 3/109:45 pm
SCL
-
DSM
1 stop18h 33m
Avianca
Deal found 1/20$841
This Bravofly deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Bravofly is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/412:04 pm
DSM
-
SCL
1 stop16h 36m
LATAM Airlines
Wed 3/1110:10 pm
SCL
-
DSM
1 stop14h 38m
LATAM Airlines
Deal found 1/21$845
This KAYAK deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/22:59 pm
DSM
-
SCL
1 stop14h 51m
Azul
Mon 3/99:45 pm
SCL
-
DSM
2 stops18h 37m
Azul
Deal found 1/20$846
This SmartFares deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:24 am
DSM
-
SCL
1 stop23h 16m
LATAM Airlines
Mon 3/910:10 pm
SCL
-
DSM
1 stop14h 38m
LATAM Airlines
Deal found 1/19$851
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/41:38 pm
DSM
-
SCL
2 stops16h 52m
American Airlines
Wed 3/119:20 pm
SCL
-
DSM
2 stops17h 58m
American Airlines
Deal found 1/21$852
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:24 am
DSM
-
SCL
1 stop23h 16m
Delta
Thu 3/1210:10 pm
SCL
-
DSM
1 stop14h 38m
Delta
Deal found 1/20$858
This KAYAK deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:59 pm
DSM
-
SCL
1 stop14h 51m
Avianca
Mon 3/99:45 pm
SCL
-
DSM
2 stops17h 38m
Avianca
Deal found 1/20$860
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/16:55 pm
DSM
-
SCL
2 stops34h 55m
United Airlines
Wed 3/119:45 pm
SCL
-
DSM
1 stop18h 33m
United Airlines
Deal found 1/20$863

Find flight deals from Des Moines to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$841
(KAYAK)

One-way from

$457
(Delta)

Popular in

December

Cheapest in

October

Average price

$1,053
Provider with most accurate pricing for Des Moines-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Santiago Arturo Merino Benitez flights.
Search Deals
From Des Moines to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Des Moines to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($72 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($58 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Des Moines to Santiago that are best for you.

Fly from

Des Moines

Fly to

Santiago

Route

Depart

Return

Price

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Wed 3/4

12:04 pm-7:40 am

1 stop16h 36m

Santiago Arturo Merino Benitez

Wed 3/11

10:10 pm-10:48 am

1 stop14h 38m

$845

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Wed 3/4

1:38 pm-9:30 am

2 stops16h 52m

Santiago Arturo Merino Benitez

Wed 3/11

9:20 pm-1:18 pm

2 stops17h 58m

$852

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Thu 3/5

5:27 am-7:40 am

1 stop23h 13m

Santiago Arturo Merino Benitez

Wed 3/11

12:20 am-10:38 pm

2 stops24h 18m

$858

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Thu 3/5

2:59 pm-8:50 am

1 stop14h 51m

Santiago Arturo Merino Benitez

Thu 3/12

9:45 pm-2:18 pm

1 stop18h 33m

$858

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Wed 3/4

5:15 pm-4:30 am

2 stops32h 15m

Santiago Arturo Merino Benitez

Thu 3/12

10:10 pm-4:33 pm

1 stop20h 23m

$858

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Mon 3/9

2:59 pm-7:50 am

1 stop14h 51m

Santiago Arturo Merino Benitez

Wed 3/18

9:45 pm-4:07 pm

2 stops20h 22m

$858

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Mon 3/2

5:24 am-7:40 am

1 stop23h 16m

Santiago Arturo Merino Benitez

Mon 3/9

6:35 pm-4:33 pm

2 stops23h 58m

$858

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Sun 3/1

6:55 pm-8:50 am

2 stops34h 55m

Santiago Arturo Merino Benitez

Tue 3/10

9:45 pm-2:18 pm

1 stop18h 33m

$863

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Wed 3/11

2:59 pm-7:50 am

1 stop14h 51m

Santiago Arturo Merino Benitez

Tue 3/17

9:45 pm-2:18 pm

1 stop18h 33m

$873

Des MoinesSantiago

DSM - SCL

DSMSCL

Des Moines

Fri 3/6

10:36 am-5:35 am

2 stops15h 59m

$457

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Showing 1-10 of 14 results
1
2

Compare providers for flights from Des Moines to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santiago in January.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Santiago flights, Cheapflights users trust AranGrant the most. AranGrant has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated January 21, 2026.
Read through reviews of airlines operating flights from Des Moines to Santiago, such as LATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,913 reviews

Food

6.7

Crew

8.0

Overall

7.5

Comfort

7.3

Boarding

7.6

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

JC,Jan 2026

FLN - GRU

Plane was late in FLN and missed connection in GRU. No alternative was given to me until 6 hours later and I was delayed by over 12 hours total.
LATAM Airlines
7.5
Good
1,913 reviews
LATAM Airlines
7.5
Good
1,913 reviews

Food

6.7

Crew

8.0

Overall

7.5

Comfort

7.3

Boarding

7.6

Entertainment

7.0

Reviews

1 / 20
2.0
Mediocre

JC,Jan 2026

FLN - GRU

Plane was late in FLN and missed connection in GRU. No alternative was given to me until 6 hours later and I was delayed by over 12 hours total.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Santiago?

    There are many flights that can get you from Des Moines to Santiago in 16h 36m. Fly via LATAM Airlines or Delta to get the fastest option. Des Moines and Santiago are separated by a distance of 5374 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Des Moines to Santiago round-trip?

    Currently priced at $814, LATAM Airlines will fly you from Des Moines to Santiago and back. In addition to LATAM Airlines, many other airlines offer competitively priced options for your trip. LATAM Airlines is 28% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Santiago that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santiago.

  • Can I find deals for business class flights from Des Moines to Santiago?

    Yes. Cheapflights offers flight deals from Des Moines to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Des Moines to Santiago

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Top airline flying from Des Moines to Santiago

Discover the top airline that operate flights from Des Moines to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$814Average$1,203FlexibilityNo cancel feeOn-time81%

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