$225+ Cheap flights from Des Moines (DSM) to Cancún (CUN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/17. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CUN
May 26 — Jun 21
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Cancún with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Cancún
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Cheapest flights from Des Moines to CancúnExplore the most affordable flight options available from Des Moines to Cancún. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 26, 2026.
Explore the most affordable flight options available from Des Moines to Cancún. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:37 pm
DSM
- CUN
1 stop17h 43m
Multiple Airlines
Thu 6/1110:25 am
CUN
- DSM
1 stop11h 02m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$393
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- CUN
1 stop22h 32m
Frontier
Mon 6/1511:02 am
CUN
- DSM
2 stops50h 29m
Frontier
Deal found 4/24![Frontier logo]()
$429
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/183:57 pm
DSM
- CUN
2 stops21h 54m
Multiple Airlines
Thu 6/2510:25 am
CUN
- DSM
1 stop11h 22m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$430
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:02 pm
DSM
- CUN
1 stop16h 18m
Multiple Airlines
Sun 6/1410:25 am
CUN
- DSM
1 stop12h 27m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$437
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:41 pm
DSM
- CUN
1 stop16h 39m
Multiple Airlines
Sun 5/311:31 pm
CUN
- DSM
2 stops33h 53m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$438
This FlightHub deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- CUN
1 stop21h 48m
Frontier
Tue 6/23:39 pm
CUN
- DSM
1 stop21h 52m
Frontier
Deal found 4/26![Frontier logo]()
$452
Best flights from Des Moines to CancúnDiscover carefully curated flight deals from Des Moines to Cancún that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 26, 2026.
Discover carefully curated flight deals from Des Moines to Cancún that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 26, 2026.
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/147:00 am
DSM
- CUN
2 stops12h 31m
Delta
Wed 8/198:00 am
CUN
- DSM
2 stops12h 45m
Delta
Deal found 4/23![Delta logo]()
$523
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:20 am
DSM
- CUN
1 stop6h 13m
United Airlines
Tue 8/112:49 pm
CUN
- DSM
2 stops9h 45m
United Airlines
Deal found 4/22![United Airlines logo]()
$567
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:10 am
DSM
- CUN
1 stop8h 20m
Southwest
Mon 6/224:10 pm
CUN
- DSM
1 stop7h 20m
Southwest
Deal found 4/22![Southwest logo]()
$618
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:26 am
DSM
- CUN
2 stops9h 50m
Delta
Tue 6/29:18 am
CUN
- DSM
2 stops13h 14m
Delta
Deal found 4/25![Delta logo]()
$554
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:50 am
DSM
- CUN
2 stops8h 47m
United Airlines
Mon 9/142:49 pm
CUN
- DSM
1 stop7h 37m
United Airlines
Deal found 4/26![United Airlines logo]()
$618
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:01 am
DSM
- CUN
2 stops12h 42m
Delta
Wed 5/208:00 am
CUN
- DSM
1 stop14h 32m
Delta
Deal found 4/21![Delta logo]()
$575
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:00 am
DSM
- CUN
1 stop8h 26m
United Airlines
Mon 7/63:24 pm
CUN
- DSM
1 stop7h 11m
United Airlines
Deal found 4/24![United Airlines logo]()
$618
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/252:15 pm
DSM
- CUN
1 stop6h 00m
Delta
Wed 9/309:30 am
CUN
- DSM
2 stops12h 56m
Delta
Deal found 4/25![Delta logo]()
$593
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/192:48 pm
DSM
- CUN
1 stop5h 37m
Delta
Fri 6/268:00 am
CUN
- DSM
2 stops12h 52m
Delta
Deal found 4/21![Delta logo]()
$597
Last-minute flights from Des Moines to CancúnDiscover last-minute flight deals from Des Moines to Cancún. Data last updated April 26, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Cancún. Data last updated April 26, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:00 am
DSM
- CUN
2 stops22h 15m
Multiple Airlines
Sun 5/243:39 pm
CUN
- DSM
1 stop21h 52m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$492
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:05 pm
DSM
- CUN
1 stop16h 00m
American Airlines
Wed 5/2012:05 pm
CUN
- DSM
1 stop11h 54m
American Airlines
Deal found 4/21![American Airlines logo]()
$532
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:41 pm
DSM
- CUN
1 stop16h 39m
Multiple Airlines
Sun 5/311:31 pm
CUN
- DSM
2 stops33h 53m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$438
This FlightHub deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- CUN
1 stop21h 48m
Frontier
Tue 6/23:39 pm
CUN
- DSM
1 stop21h 52m
Frontier
Deal found 4/26![Frontier logo]()
$452
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/308:02 pm
DSM
- CUN
1 stop16h 06m
American Airlines
Wed 6/33:59 pm
CUN
- DSM
1 stop7h 58m
American Airlines
Deal found 4/21![American Airlines logo]()
$550
One-way flights from Des Moines to CancúnSearch for one-way flight options from Des Moines to Cancún. Find affordable one-way fares based on user searches. Data last updated April 26, 2026.
Search for one-way flight options from Des Moines to Cancún. Find affordable one-way fares based on user searches. Data last updated April 26, 2026.
This Orbitz deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/172:19 pm
DSM
- CUN
1 stop22h 30m
Frontier
Deal found 4/23![Frontier logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:16 pm
DSM
- CUN
2 stops42h 59m
Frontier
Deal found 4/22![Frontier logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:45 am
DSM
- CUN
3 stops49h 24m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$257
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:02 pm
DSM
- CUN
1 stop15h 01m
American Airlines
Deal found 4/22![American Airlines logo]()
$270
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/35:10 am
DSM
- CUN
2 stops8h 50m
Southwest
Deal found 4/23![Southwest logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/153:32 pm
DSM
- CUN
3 stops22h 09m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:15 pm
DSM
- CUN
2 stops36h 54m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$295
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/175:10 am
DSM
- CUN
2 stops8h 50m
Southwest
Deal found 4/23![Southwest logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1710:01 pm
DSM
- CUN
3 stops36h 02m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$333
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:51 am
DSM
- CUN
1 stop8h 24m
Delta
Deal found 4/25![Delta logo]()
$337
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/72:33 pm
DSM
- CUN
1 stop5h 43m
Delta
Deal found 4/22![Delta logo]()
$342
Find flight deals from Des Moines to Cancún
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Cancún (CUN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $393 (Kiwi.com) |
One-way from | $225 (Orbitz) |
Popular in | April |
Cheapest in | September |
Average price | $682 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Cancún that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 26, 2026.
Use the filters below to find and compare flights from Des Moines to Cancún that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 8/14
7:00 am-7:31 pm
2 stops12h 31m
Cancun
Wed 8/19
8:00 am-8:45 pm
2 stops12h 45m
$523
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 5/27
10:26 am-8:16 pm
2 stops9h 50m
Cancun
Tue 6/2
9:18 am-10:32 pm
2 stops13h 14m
$554
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Sat 8/8
6:20 am-12:33 pm
1 stop6h 13m
Cancun
Tue 8/11
2:49 pm-12:34 am
2 stops9h 45m
$567
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Sat 5/16
7:01 am-7:43 pm
2 stops12h 42m
Cancun
Wed 5/20
8:00 am-10:32 pm
1 stop14h 32m
$575
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 9/25
2:15 pm-8:15 pm
1 stop6h 00m
Cancun
Wed 9/30
9:30 am-10:26 pm
2 stops12h 56m
$593
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 6/19
2:48 pm-8:25 pm
1 stop5h 37m
Cancun
Fri 6/26
8:00 am-8:52 pm
2 stops12h 52m
$597
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Thu 6/18
5:10 am-1:30 pm
1 stop8h 20m
Cancun
Mon 6/22
4:10 pm-11:30 pm
1 stop7h 20m
$618
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Thu 9/10
5:50 am-2:37 pm
2 stops8h 47m
Cancun
Mon 9/14
2:49 pm-10:26 pm
1 stop7h 37m
$618
Quickest round-trip
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 7/3
6:00 am-2:26 pm
1 stop8h 26m
Cancun
Mon 7/6
3:24 pm-10:35 pm
1 stop7h 11m
$618
Cheapest one-way
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Thu 5/7
7:45 am-9:09 am
3 stops49h 24m
$257
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Cancún
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Cancún in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Cancún flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Cancún flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Cancún flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Cancún flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Cancún flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Cancún
Have a flexible travel schedule? Discover the best time to fly to Cancún from Des Moines with our price prediction graph.
DSM-CUN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Cancún
How far ahead should I book a flight from Des Moines to Cancún?
The best time to book flights from Des Moines to Cancún is 15 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Des Moines to Cancún?
Currently, September is the cheapest month in which you can book a flight from Des Moines to Cancún (average of $465). Flying from Des Moines to Cancún in April is currently the most expensive (average of $682). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Cancún?
Reviews of airlines servicing Cancún
Get insights into the airlines that provide service to Cancún. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cancún. Reviews last updated April 26, 2026.
Read through reviews of airlines operating flights from Des Moines to Cancún, such as Southwest,Delta, andUnited Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Overall
8.0
Comfort
8.0
Food
7.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Overall
8.0
Comfort
8.0
Food
7.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Overall
8.0
Comfort
8.0
Food
7.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Overall
8.0
Comfort
8.0
Food
7.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Overall
8.0
Comfort
8.0
Food
7.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Overall
8.0
Comfort
8.0
Food
7.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Cancún. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Cancún?
Book flights to Cancún if you plan to visit one of these locationsPuerto Aventuras
Punta Sam
Holbox
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Other flights to Cancún
Explore flights to Cancún departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 26, 2026.
Complete your trip
Complete your trip to Cancún by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and Cancún flights
Browse other Des Moines and Cancún flight options. Last updated on April 26, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on April 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 5 airlines flying from Des Moines to Cancún
Discover the top 5 airlines that operate flights from Des Moines to Cancún. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$276 | Average$520 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$397 | Average$626 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$444 | Average$618 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$468 | Average$629 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$569 | Average$697 | FlexibilityNo cancel fee | On-time63% |