$180+ Cheap flights from Des Moines (DSM) to Mexico
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
Nov 19 — Nov 261
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:04 pm -
1 stop25h 06m
Fri 11/138:00 am -
1 stop11h 35m
Deal found 10/16![Multiple Airlines logo]()
$438
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:28 pm -
1 stop20h 22m
Thu 12/38:00 am -
1 stop11h 40m
Deal found 10/16![Multiple Airlines logo]()
$456
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:35 pm -
2 stops26h 10m
Thu 12/108:00 am -
1 stop11h 42m
Deal found 10/19![Multiple Airlines logo]()
$461
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/239:31 pm -
2 stops26h 44m
Thu 12/38:00 am -
1 stop11h 40m
Deal found 10/16![Multiple Airlines logo]()
$470
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:41 pm -
2 stops27h 34m
Thu 12/38:00 am -
1 stop11h 40m
Deal found 10/16![Multiple Airlines logo]()
$491
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:35 pm -
1 stop20h 15m
Wed 12/97:00 am -
2 stops33h 46m
Deal found 10/16![Multiple Airlines logo]()
$496
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:35 pm -
2 stops26h 10m
Sun 12/68:00 am -
1 stop11h 50m
Deal found 10/16![Multiple Airlines logo]()
$502
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/259:20 pm -
2 stops33h 50m
Thu 12/38:00 am -
1 stop11h 40m
Deal found 10/16![Multiple Airlines logo]()
$507
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:35 pm -
2 stops27h 24m
Thu 12/102:07 pm -
1 stop19h 43m
Deal found 10/19![Multiple Airlines logo]()
$514
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:31 pm -
1 stop16h 55m
Thu 12/105:36 pm -
1 stop7h 23m
Deal found 10/19![American Airlines logo]()
$536
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:18 pm -
1 stop20h 29m
Wed 1/277:00 am -
2 stops30h 19m
Deal found 10/15![Multiple Airlines logo]()
$542
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:05 am -
1 stop6h 57m
Tue 12/151:42 pm -
1 stop9h 43m
Deal found 10/19![American Airlines logo]()
$563
Best flights from Des Moines to MexicoDiscover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/49:18 pm -
1 stop22h 43m
Wed 1/2711:54 am -
1 stop29h 10m
Deal found 10/16![Multiple Airlines logo]()
$592
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/237:38 pm -
2 stops17h 44m
Tue 3/21:10 pm -
2 stops19h 32m
Deal found 10/18![American Airlines logo]()
$596
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/206:15 am -
1 stop8h 15m
Wed 1/271:35 pm -
1 stop8h 03m
Deal found 10/18![United Airlines logo]()
$610
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/65:20 am -
1 stop14h 48m
Wed 12/91:40 pm -
1 stop7h 59m
Deal found 10/19![Delta logo]()
$610
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/305:10 am -
1 stop6h 40m
Thu 12/312:35 pm -
2 stops10h 30m
Deal found 10/14![Southwest logo]()
$615
This Bravofly deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Bravofly is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/295:30 am -
1 stop16h 20m
Sun 12/612:30 pm -
1 stop10h 08m
Deal found 10/15![Aeromexico logo]()
$706
This FlightHub deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:39 pm -
2 stops21h 08m
Fri 12/118:51 pm -
2 stops46h 51m
Deal found 10/19![Frontier logo]()
$729
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/88:00 am -
1 stop6h 24m
Wed 1/138:39 am -
1 stop6h 40m
Deal found 10/18![United Airlines logo]()
$635
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2110:15 am -
2 stops10h 00m
Tue 1/263:10 pm -
1 stop8h 19m
Deal found 10/16![Delta logo]()
$640
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/225:55 am -
2 stops8h 30m
Fri 1/2912:10 pm -
2 stops10h 25m
Deal found 10/14![Southwest logo]()
$640
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:27 pm -
1 stop16h 57m
Wed 11/113:52 pm -
2 stops17h 15m
Deal found 10/14![American Airlines logo]()
$665
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/299:20 pm -
2 stops22h 25m
Sun 12/68:00 am -
1 stop11h 50m
Deal found 10/15![Multiple Airlines logo]()
$694
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/186:20 am -
2 stops9h 10m
Sun 1/248:15 am -
1 stop9h 12m
Deal found 10/16![Delta logo]()
$640
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/195:10 am -
2 stops10h 45m
Thu 2/253:40 pm -
1 stop8h 10m
Deal found 10/16![Southwest logo]()
$640
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/18:00 am -
2 stops13h 07m
Tue 12/85:55 am -
1 stop8h 20m
Deal found 10/16![United Airlines logo]()
$649
This Aeromexico deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/72:58 pm -
2 stops18h 39m
Wed 1/278:20 am -
1 stop8h 07m
Deal found 10/19![Aeromexico logo]()
$737
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:23 am -
2 stops33h 03m
Wed 12/21:30 pm -
1 stop9h 00m
Deal found 10/19![American Airlines logo]()
$684
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/166:20 am -
2 stops9h 10m
Thu 1/211:55 pm -
1 stop8h 29m
Deal found 10/14![Delta logo]()
$640
This United Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/258:00 am -
1 stop12h 31m
Tue 3/3012:55 pm -
1 stop8h 35m
Deal found 10/17![United Airlines logo]()
$663
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/215:10 am -
2 stops11h 10m
Thu 12/248:20 am -
2 stops13h 30m
Deal found 10/18![Southwest logo]()
$670
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/137:38 pm -
1 stop17h 42m
Sat 2/271:10 pm -
1 stop9h 38m
Deal found 10/19![American Airlines logo]()
$688
This Delta deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/255:45 am -
2 stops15h 03m
Tue 3/306:14 am -
2 stops15h 15m
Deal found 10/17![Delta logo]()
$663
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/233:01 pm -
1 stop9h 09m
Wed 12/23:30 pm -
1 stop6h 51m
Deal found 10/19![United Airlines logo]()
$677
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1011:40 am -
1 stop12h 19m
Fri 12/119:45 am -
1 stop10h 43m
Deal found 10/19![Multiple Airlines logo]()
$834
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:20 am -
2 stops9h 45m
Sun 12/133:30 pm -
2 stops8h 35m
Deal found 10/16![Southwest logo]()
$696
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/173:20 pm -
2 stops23h 00m
Fri 4/301:10 pm -
2 stops20h 16m
Deal found 10/15![American Airlines logo]()
$697
This FlightHub deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:30 pm -
2 stops33h 25m
Sun 11/1510:25 am -
2 stops33h 10m
Deal found 10/16![Frontier logo]()
$940
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:30 am -
2 stops11h 05m
Mon 11/238:35 am -
2 stops14h 00m
Deal found 10/15![Delta logo]()
$681
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/71:23 pm -
2 stops9h 12m
Wed 1/275:45 am -
2 stops10h 26m
Deal found 10/15![United Airlines logo]()
$689
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:15 pm -
2 stops17h 25m
Sat 12/1210:05 am -
2 stops8h 35m
Deal found 10/16![Southwest logo]()
$700
Last-minute flights from Des Moines to MexicoDiscover last-minute flight deals from Des Moines to Mexico. Data last updated October 20, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico. Data last updated October 20, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/87:37 pm -
1 stop14h 21m
Fri 11/134:00 pm -
1 stop17h 46m
Deal found 10/16![American Airlines logo]()
$610
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:04 pm -
1 stop25h 06m
Fri 11/138:00 am -
1 stop11h 35m
Deal found 10/16![Multiple Airlines logo]()
$438
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:00 am -
1 stop14h 14m
Tue 11/176:27 pm -
1 stop15h 40m
Deal found 10/19![American Airlines logo]()
$599
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/239:31 pm -
2 stops26h 44m
Thu 12/38:00 am -
1 stop11h 40m
Deal found 10/16![Multiple Airlines logo]()
$470
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/239:31 pm -
1 stop22h 34m
Wed 12/27:00 am -
2 stops33h 46m
Deal found 10/16![Multiple Airlines logo]()
$537
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/259:20 pm -
2 stops33h 50m
Thu 12/38:00 am -
1 stop11h 40m
Deal found 10/16![Multiple Airlines logo]()
$507
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:28 pm -
1 stop20h 22m
Thu 12/38:00 am -
1 stop11h 40m
Deal found 10/16![Multiple Airlines logo]()
$456
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:28 pm -
1 stop20h 22m
Wed 12/27:00 am -
2 stops33h 46m
Deal found 10/16![Multiple Airlines logo]()
$512
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:41 pm -
2 stops27h 34m
Thu 12/38:00 am -
1 stop11h 40m
Deal found 10/16![Multiple Airlines logo]()
$491
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/287:16 pm -
1 stop16h 05m
Tue 12/82:21 pm -
1 stop6h 38m
Deal found 10/19![American Airlines logo]()
$563
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:15 am -
2 stops13h 10m
Fri 12/412:05 pm -
1 stop8h 23m
Deal found 10/16![Multiple Airlines logo]()
$513
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/305:01 am -
1 stop8h 52m
Thu 12/35:13 pm -
1 stop7h 49m
Deal found 10/14![American Airlines logo]()
$592
One-way flights from Des Moines to MexicoSearch for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/153:27 pm -
2 stops42h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Multiple Airlines logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:00 am -
3 stops57h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/153:27 pm -
2 stops30h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Multiple Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/239:31 pm -
2 stops36h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Multiple Airlines logo]()
$222
This CheapOair deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:28 pm -
1 stop20h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Frontier logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/168:30 pm -
1 stop20h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Multiple Airlines logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/317:45 am -
2 stops12h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Multiple Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/138:30 pm -
2 stops36h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$232
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/119:18 pm -
1 stop22h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/209:31 pm -
2 stops26h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Multiple Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:41 pm -
2 stops36h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Multiple Airlines logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/318:26 pm -
2 stops20h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$258
Find flight deals from Des Moines to Mexico
Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated October 20, 2026.
Round-trip from | $438 (Kiwi.com) |
|---|---|
One-way from | $180 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesGuadalajara
DSM Des Moines - GDL Guadalajara Miguel Hidal
DSMGDL
Des Moines
Fri 11/20
9:31 pm-8:01 pm
1 stop22h 30m
Guadalajara Miguel Hidal
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$260
Des MoinesCancún
DSM Des Moines - CUN Cancun
DSMCUN
Des Moines
Sun 11/15
3:27 pm-9:45 pm
2 stops29h 18m
Cancun
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$262
Des MoinesMazatlán
DSM Des Moines - MZT Mazatlán Gen Rafael Buelna
DSMMZT
Des Moines
Sun 11/15
5:00 am-1:21 pm
1 stop9h 21m
Mazatlán Gen Rafael Buelna
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$263
Des MoinesGuadalajara
DSM Des Moines - GDL Guadalajara Miguel Hidal
DSMGDL
Des Moines
Fri 12/4
9:18 pm-5:47 pm
1 stop20h 29m
Guadalajara Miguel Hidal
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$284
Des MoinesCancún
DSM Des Moines - CUN Cancun
DSMCUN
Des Moines
Mon 3/15
5:48 pm-10:45 am
2 stops40h 57m
Cancun
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$289
Des MoinesGuadalajara
DSM Des Moines - GDL Guadalajara Miguel Hidal
DSMGDL
Des Moines
Thu 12/10
8:39 pm-11:59 pm
2 stops27h 20m
Guadalajara Miguel Hidal
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$294
Des MoinesCancún
DSM Des Moines - CUN Cancun
DSMCUN
Des Moines
Sat 1/16
5:07 pm-11:20 am
2 stops17h 13m
Cancun
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$296
Des MoinesCancún
DSM Des Moines - CUN Cancun
DSMCUN
Des Moines
Mon 2/15
7:00 am-3:20 pm
1 stop7h 20m
Cancun
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$296
Des MoinesCancún
DSM Des Moines - CUN Cancun
DSMCUN
Des Moines
Mon 11/30
5:10 am-12:50 pm
1 stop6h 40m
Cancun
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$296
Des MoinesCancún
DSM Des Moines - CUN Cancun
DSMCUN
Des Moines
Tue 11/10
5:30 am-3:24 pm
2 stops8h 54m
Cancun
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$296
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mexico
Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
DSM-MEX
DSM-PVR
DSM-CUN
DSM-BJX
DSM-GDL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico
DSM-MX0
DSM-MEX
DSM-PVR
DSM-CUN
DSM-BJX
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $595). Flying from Des Moines to Mexico in December is currently the most expensive (average of $778). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How far ahead should I book a flight from Des Moines to Mexico?
Booking 16 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Mexico. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Reviews of airlines servicing Mexico
Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated October 20, 2026.
See what other customers who have flown with Southwest,Delta, andAeromexico from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.5
Crew
8.6
Food
7.0
Boarding
8.1
Comfort
8.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mexico
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Complete your trip
Complete your trip to Mexico by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Mexico, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Mexico flights
Browse other Des Moines and Mexico flight options. Last updated on October 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to Mexico flights
Consider these flights traveling from Des Moines to Mexico.
Fly to Mexico regions
Consider these flights traveling to Mexico regions.
Top 5 airlines flying from Des Moines to Mexico
Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$229 | Average$620 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$459 | Average$705 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$465 | Average$677 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$473 | Average$699 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$569 | Average$772 | FlexibilityNo cancel fee | On-time63% |