$194+ Cheap flights from Des Moines (DSM) to Mexico
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
Apr 25 — May 21
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2026.
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2026.
This Expedia deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
- CUN
1 stop15h 41m
Frontier
Tue 5/123:39 pm
CUN
- DSM
1 stop21h 52m
Frontier
Deal found 3/24![Frontier logo]()
$261
This Priceline deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:16 pm
DSM
- CUN
1 stop21h 48m
Frontier
Sun 5/103:39 pm
CUN
- DSM
1 stop21h 52m
Frontier
Deal found 3/24![Frontier logo]()
$331
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:00 am
DSM
- CUN
1 stop9h 55m
American Airlines
Tue 5/123:01 pm
CUN
- DSM
1 stop8h 15m
American Airlines
Deal found 3/23![American Airlines logo]()
$363
This American Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:44 am
DSM
- CUN
1 stop6h 24m
American Airlines
Wed 5/1312:10 pm
CUN
- DSM
1 stop10h 08m
American Airlines
Deal found 3/22![American Airlines logo]()
$368
This Expedia deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:44 pm
DSM
- CUN
1 stop5h 31m
Aeromexico
Wed 5/1312:45 pm
CUN
- DSM
1 stop9h 47m
Aeromexico
Deal found 3/21![Aeromexico logo]()
$379
This lastminute.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lastminute.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/52:44 pm
DSM
- CUN
1 stop5h 31m
Aeromexico
Tue 5/123:02 pm
CUN
- DSM
1 stop7h 30m
Aeromexico
Deal found 3/21![Aeromexico logo]()
$382
This Justfly.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/308:21 pm
DSM
- CUN
1 stop15h 00m
Frontier
Fri 4/310:13 am
CUN
- DSM
1 stop9h 01m
Frontier
Deal found 3/25![Frontier logo]()
$389
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:38 pm
DSM
- SJD
1 stop24h 08m
American Airlines
Thu 5/711:32 am
SJD
- DSM
1 stop10h 17m
American Airlines
Deal found 3/24![American Airlines logo]()
$391
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/31:37 pm
DSM
- MEX
1 stop9h 38m
Multiple Airlines
Sun 8/164:10 pm
MEX
- DSM
1 stop25h 05m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$404
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/92:39 pm
DSM
- SJD
1 stop24h 07m
American Airlines
Sat 5/1611:32 am
SJD
- DSM
1 stop10h 17m
American Airlines
Deal found 3/25![American Airlines logo]()
$417
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- MEX
1 stop22h 51m
Multiple Airlines
Mon 5/48:40 am
MEX
- DSM
1 stop9h 58m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$423
This lastminute.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lastminute.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/811:57 am
DSM
- SJD
2 stops12h 21m
Aeromexico
Fri 5/1512:35 pm
SJD
- DSM
1 stop7h 57m
Aeromexico
Deal found 3/24![Aeromexico logo]()
$426
Best flights from Des Moines to MexicoDiscover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 26, 2026.
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 26, 2026.
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:03 pm
DSM
- PVR
1 stop16h 45m
American Airlines
Fri 5/1512:48 pm
PVR
- DSM
1 stop18h 38m
American Airlines
Deal found 3/26![American Airlines logo]()
$428
This Aeromexico deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:00 am
DSM
- PVR
2 stops17h 13m
Aeromexico
Wed 5/66:03 am
PVR
- DSM
2 stops10h 42m
Aeromexico
Deal found 3/23![Aeromexico logo]()
$450
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:33 pm
DSM
- CUN
1 stop5h 43m
Delta
Fri 5/151:45 pm
CUN
- DSM
1 stop8h 47m
Delta
Deal found 3/23![Delta logo]()
$451
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- MEX
2 stops22h 46m
Multiple Airlines
Mon 5/48:40 am
MEX
- DSM
1 stop9h 58m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$468
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:20 am
DSM
- SJD
1 stop6h 10m
United Airlines
Wed 6/101:44 pm
SJD
- DSM
2 stops18h 43m
United Airlines
Deal found 3/25![United Airlines logo]()
$482
This Southwest deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:30 am
DSM
- CUN
2 stops9h 35m
Southwest
Tue 4/282:00 pm
CUN
- DSM
2 stops8h 10m
Southwest
Deal found 3/22![Southwest logo]()
$522
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:57 am
DSM
- CUN
1 stop8h 19m
Delta
Wed 5/206:03 am
CUN
- DSM
2 stops11h 50m
Delta
Deal found 3/23![Delta logo]()
$451
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:15 am
DSM
- CUN
2 stops14h 01m
Delta
Thu 5/288:08 am
CUN
- DSM
2 stops14h 24m
Delta
Deal found 3/24![Delta logo]()
$456
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:01 pm
DSM
- PVR
2 stops20h 05m
American Airlines
Thu 5/283:01 pm
PVR
- DSM
1 stop7h 32m
American Airlines
Deal found 3/25![American Airlines logo]()
$505
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- MTY
1 stop28h 49m
Multiple Airlines
Fri 5/156:18 pm
MTY
- DSM
2 stops43h 57m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$513
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/110:26 am
DSM
- CUN
2 stops9h 50m
Delta
Sat 6/68:00 am
CUN
- DSM
1 stop14h 32m
Delta
Deal found 3/25![Delta logo]()
$457
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:20 am
DSM
- SJD
1 stop7h 05m
United Airlines
Wed 4/2211:52 am
SJD
- DSM
1 stop9h 25m
United Airlines
Deal found 3/23![United Airlines logo]()
$560
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:04 pm
DSM
- GDL
2 stops34h 55m
Multiple Airlines
Thu 4/308:45 am
GDL
- DSM
1 stop8h 16m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$516
This Rumbo deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Rumbo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:45 am
DSM
- MTY
1 stop6h 55m
Aeromexico
Wed 5/139:52 pm
MTY
- DSM
2 stops23h 40m
Aeromexico
Deal found 3/21![Aeromexico logo]()
$577
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:30 am
DSM
- PVR
1 stop8h 23m
United Airlines
Wed 5/61:55 pm
PVR
- DSM
1 stop8h 49m
United Airlines
Deal found 3/25![United Airlines logo]()
$560
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:00 am
DSM
- MEX
2 stops26h 25m
Multiple Airlines
Tue 5/128:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$518
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:51 am
DSM
- SJD
2 stops12h 37m
Delta
Thu 5/76:07 am
SJD
- DSM
2 stops14h 25m
Delta
Deal found 3/24![Delta logo]()
$477
This lastminute.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lastminute.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:33 pm
DSM
- MID
2 stops18h 36m
Aeromexico
Fri 5/157:17 am
MID
- DSM
2 stops14h 15m
Aeromexico
Deal found 3/24![Aeromexico logo]()
$587
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/93:20 pm
DSM
- MID
1 stop23h 16m
American Airlines
Sat 5/162:26 pm
MID
- DSM
1 stop20h 00m
American Airlines
Deal found 3/24![American Airlines logo]()
$593
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:51 am
DSM
- PVR
2 stops11h 56m
Delta
Tue 5/128:48 am
PVR
- DSM
2 stops12h 44m
Delta
Deal found 3/25![Delta logo]()
$477
This United Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:30 am
DSM
- CZM
2 stops10h 12m
United Airlines
Wed 5/133:52 pm
CZM
- DSM
1 stop5h 53m
United Airlines
Deal found 3/22![United Airlines logo]()
$581
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/49:01 pm
DSM
- GDL
1 stop22h 14m
Multiple Airlines
Thu 6/1110:25 am
GDL
- DSM
2 stops35h 28m
Multiple Airlines
Deal found 3/26![Multiple Airlines logo]()
$535
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:00 am
DSM
- BJX
1 stop15h 59m
American Airlines
Sat 5/161:38 pm
BJX
- DSM
1 stop9h 21m
American Airlines
Deal found 3/25![American Airlines logo]()
$602
This Aeromexico deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/611:51 am
DSM
- BJX
2 stops21h 43m
Aeromexico
Wed 5/139:24 am
BJX
- DSM
1 stop7h 29m
Aeromexico
Deal found 3/22![Aeromexico logo]()
$606
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/256:50 pm
DSM
- CZM
2 stops20h 52m
United Airlines
Wed 6/33:52 pm
CZM
- DSM
1 stop5h 43m
United Airlines
Deal found 3/25![United Airlines logo]()
$586
This Aeromexico deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:27 am
DSM
- BJX
1 stop13h 37m
Aeromexico
Thu 5/289:24 am
BJX
- DSM
1 stop12h 08m
Aeromexico
Deal found 3/21![Aeromexico logo]()
$616
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:05 pm
DSM
- MLM
1 stop18h 24m
American Airlines
Sat 5/161:13 pm
MLM
- DSM
1 stop9h 46m
American Airlines
Deal found 3/24![American Airlines logo]()
$629
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:30 am
DSM
- PVR
1 stop8h 23m
United Airlines
Sun 5/1012:19 pm
PVR
- DSM
1 stop9h 26m
United Airlines
Deal found 3/25![United Airlines logo]()
$587
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- GDL
1 stop27h 13m
Multiple Airlines
Sat 5/168:40 pm
GDL
- DSM
2 stops48h 53m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$599
This Aeromexico deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:51 am
DSM
- MTY
2 stops21h 54m
Aeromexico
Tue 5/128:09 am
MTY
- DSM
1 stop13h 23m
Aeromexico
Deal found 3/21![Aeromexico logo]()
$618
Last-minute flights from Des Moines to MexicoDiscover last-minute flight deals from Des Moines to Mexico. Data last updated March 26, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico. Data last updated March 26, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/296:30 am
DSM
- CUN
1 stop7h 04m
Multiple Airlines
Fri 4/39:12 am
CUN
- DSM
2 stops52h 34m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$453
This Justfly.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/308:21 pm
DSM
- CUN
1 stop15h 00m
Frontier
Fri 4/310:13 am
CUN
- DSM
1 stop9h 01m
Frontier
Deal found 3/25![Frontier logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/3010:26 am
DSM
- CUN
1 stop21h 46m
Multiple Airlines
Sat 4/43:45 pm
CUN
- DSM
1 stop22h 01m
Multiple Airlines
Deal found 3/23![Multiple Airlines logo]()
$458
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/53:21 pm
DSM
- CUN
1 stop20h 09m
Multiple Airlines
Thu 4/912:35 pm
CUN
- DSM
1 stop9h 31m
Multiple Airlines
Deal found 3/23![Multiple Airlines logo]()
$416
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/53:21 pm
DSM
- CUN
1 stop20h 09m
Multiple Airlines
Wed 4/82:39 pm
CUN
- DSM
2 stops23h 07m
Multiple Airlines
Deal found 3/23![Multiple Airlines logo]()
$436
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:14 pm
DSM
- CUN
2 stops11h 58m
Multiple Airlines
Thu 4/92:39 pm
CUN
- DSM
1 stop7h 27m
Multiple Airlines
Deal found 3/23![Multiple Airlines logo]()
$437
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:00 am
DSM
- PVR
1 stop6h 22m
American Airlines
Tue 4/213:10 pm
PVR
- DSM
2 stops19h 16m
American Airlines
Deal found 3/23![American Airlines logo]()
$455
This Aeromexico deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:00 am
DSM
- CUN
1 stop7h 05m
Aeromexico
Tue 4/286:01 am
CUN
- DSM
2 stops16h 33m
Aeromexico
Deal found 3/25![Aeromexico logo]()
$425
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:00 am
DSM
- CUN
2 stops13h 15m
Delta
Tue 4/288:00 am
CUN
- DSM
1 stop14h 34m
Delta
Deal found 3/24![Delta logo]()
$430
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:05 pm
DSM
- CUN
1 stop16h 00m
American Airlines
Tue 4/282:58 pm
CUN
- DSM
1 stop8h 51m
American Airlines
Deal found 3/25![American Airlines logo]()
$452
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2410:14 pm
DSM
- GDL
1 stop19h 33m
Multiple Airlines
Fri 5/110:25 am
GDL
- DSM
1 stop9h 59m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$469
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:56 pm
DSM
- SJD
1 stop17h 36m
American Airlines
Thu 4/302:59 pm
SJD
- DSM
1 stop7h 00m
American Airlines
Deal found 3/24![American Airlines logo]()
$450
One-way flights from Des Moines to MexicoSearch for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated March 26, 2026.
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated March 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:04 pm
DSM
- GDL
2 stops34h 55m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$194
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:00 am
DSM
- CUN
1 stop7h 52m
American Airlines
Deal found 3/25![American Airlines logo]()
$198
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:01 am
DSM
- CUN
2 stops12h 42m
Delta
Deal found 3/25![Delta logo]()
$202
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:56 pm
DSM
- SJD
1 stop17h 36m
American Airlines
Deal found 3/23![American Airlines logo]()
$203
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:00 am
DSM
- PVR
1 stop8h 29m
American Airlines
Deal found 3/23![American Airlines logo]()
$203
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/157:32 pm
DSM
- PVR
1 stop16h 09m
American Airlines
Deal found 3/24![American Airlines logo]()
$219
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:01 pm
DSM
- SJD
1 stop15h 01m
American Airlines
Deal found 3/25![American Airlines logo]()
$230
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:15 pm
DSM
- SJD
2 stops16h 15m
United Airlines
Deal found 3/25![United Airlines logo]()
$236
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/297:00 am
DSM
- SJD
2 stops12h 49m
Delta
Deal found 3/23![Delta logo]()
$242
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:00 am
DSM
- CUN
1 stop7h 52m
American Airlines
Deal found 3/23![American Airlines logo]()
$242
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:03 pm
DSM
- SJD
1 stop18h 47m
American Airlines
Deal found 3/23![American Airlines logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/319:00 am
DSM
- MLM
2 stops31h 05m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$248
Find flight deals from Des Moines to Mexico
Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated March 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $261 (Expedia) |
One-way from | $194 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $549 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesPuerto Vallarta
DSM - PVR
DSMPVR
Des Moines
Fri 5/8
8:03 pm-11:48 am
1 stop16h 45m
Puerto Vallarta Ordaz
Fri 5/15
12:48 pm-8:26 am
1 stop18h 38m
$428
Des MoinesPuerto Vallarta
DSM - PVR
DSMPVR
Des Moines
Tue 5/5
7:00 am-11:13 pm
2 stops17h 13m
Puerto Vallarta Ordaz
Wed 5/6
6:03 am-5:45 pm
2 stops10h 42m
$450
Quickest round-trip
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 5/8
2:33 pm-8:16 pm
1 stop5h 43m
Cancun
Fri 5/15
1:45 pm-10:32 pm
1 stop8h 47m
$451
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Sat 5/16
11:57 am-8:16 pm
1 stop8h 19m
Cancun
Wed 5/20
6:03 am-5:53 pm
2 stops11h 50m
$451
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Sat 5/23
6:15 am-8:16 pm
2 stops14h 01m
Cancun
Thu 5/28
8:08 am-10:32 pm
2 stops14h 24m
$456
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Mon 6/1
10:26 am-8:16 pm
2 stops9h 50m
Cancun
Sat 6/6
8:00 am-10:32 pm
1 stop14h 32m
$457
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Fri 5/1
10:14 pm-8:00 pm
2 stops22h 46m
Mexico City Benito Juarez
Mon 5/4
8:40 am-7:38 pm
1 stop9h 58m
$468
Des MoinesSan José del Cabo
DSM - SJD
DSMSJD
Des Moines
Sat 5/2
11:51 am-10:28 pm
2 stops12h 37m
San José del Cabo Los Cabos
Thu 5/7
6:07 am-10:32 pm
2 stops14h 25m
$477
Des MoinesPuerto Vallarta
DSM - PVR
DSMPVR
Des Moines
Sat 5/2
11:51 am-10:47 pm
2 stops11h 56m
Puerto Vallarta Ordaz
Tue 5/12
8:48 am-10:32 pm
2 stops12h 44m
$477
Des MoinesSan José del Cabo
DSM - SJD
DSMSJD
Des Moines
Fri 6/5
6:20 am-10:30 am
1 stop6h 10m
San José del Cabo Los Cabos
Wed 6/10
1:44 pm-10:27 am
2 stops18h 43m
$482
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mexico
Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
DSM-GDL
DSM-CUN
DSM-SJD
DSM-PVR
DSM-MLM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico
DSM-MX0
DSM-GDL
DSM-CUN
DSM-SJD
DSM-PVR
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, October is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $241). Flying from Des Moines to Mexico in June is currently the most expensive (average of $468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Mexico
Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated March 26, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mexico
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Complete your trip
Complete your trip to Mexico by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Mexico, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Mexico flights
Browse other Des Moines and Mexico flight options. Last updated on March 26, 2026.
Popular flight searches
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Des Moines to Mexico flights
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Consider these flights traveling to Mexico regions.
Top 5 airlines flying from Des Moines to Mexico
Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$276 | Average$480 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$366 | Average$657 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$379 | Average$654 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$397 | Average$616 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$569 | Average$697 | FlexibilityNo cancel fee | On-time63% |