$147+ Cheap flights from Des Moines (DSM) to Mexico
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
May 17 — May 241
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2026.
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/124:57 pm
DSM
- CUN
1 stop16h 18m
Multiple Airlines
Thu 7/1610:25 am
CUN
- DSM
1 stop11h 02m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$366
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:37 pm
DSM
- CUN
2 stops20h 27m
Multiple Airlines
Thu 6/1110:25 am
CUN
- DSM
1 stop11h 02m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$403
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CUN
2 stops21h 26m
Multiple Airlines
Thu 6/410:30 am
CUN
- DSM
1 stop10h 57m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$407
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Wed 6/39:05 pm
MEX
- DSM
2 stops23h 22m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$409
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:41 pm
DSM
- CUN
1 stop16h 39m
Multiple Airlines
Sun 5/3110:34 am
CUN
- DSM
2 stops26h 57m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$410
This FlightHub deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- CUN
2 stops24h 13m
Frontier
Tue 6/23:39 pm
CUN
- DSM
1 stop21h 52m
Frontier
Deal found 4/16![Frontier logo]()
$412
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/264:57 pm
DSM
- CUN
1 stop16h 18m
Multiple Airlines
Thu 7/303:35 pm
CUN
- DSM
1 stop21h 56m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$419
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:48 pm
DSM
- MEX
2 stops47h 42m
Multiple Airlines
Sun 5/178:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$474
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Fri 6/511:00 am
MEX
- DSM
1 stop9h 06m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$476
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- MEX
2 stops49h 49m
Multiple Airlines
Thu 6/48:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$487
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:48 pm
DSM
- MEX
2 stops47h 42m
Multiple Airlines
Sat 5/1611:55 am
MEX
- DSM
1 stop29h 06m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$493
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- GDL
1 stop27h 13m
Multiple Airlines
Tue 5/267:13 am
GDL
- DSM
2 stops29h 18m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$501
Best flights from Des Moines to MexicoDiscover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 17, 2026.
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- MTY
2 stops33h 19m
Multiple Airlines
Fri 6/512:05 pm
MTY
- DSM
1 stop8h 01m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$518
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/146:20 am
DSM
- CUN
1 stop5h 42m
United Airlines
Thu 6/1812:55 pm
CUN
- DSM
1 stop8h 45m
United Airlines
Deal found 4/14![United Airlines logo]()
$568
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:07 am
DSM
- CUN
1 stop6h 58m
Delta
Wed 7/88:00 am
CUN
- DSM
2 stops12h 49m
Delta
Deal found 4/12![Delta logo]()
$572
This Aeromexico deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:27 am
DSM
- PVR
1 stop8h 04m
Aeromexico
Fri 5/151:41 pm
PVR
- DSM
1 stop7h 51m
Aeromexico
Deal found 4/12![Aeromexico logo]()
$587
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/146:10 am
DSM
- CUN
1 stop9h 35m
Southwest
Thu 6/181:00 pm
CUN
- DSM
2 stops10h 30m
Southwest
Deal found 4/14![Southwest logo]()
$622
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/115:37 am
DSM
- SJD
1 stop7h 13m
American Airlines
Fri 10/161:25 pm
SJD
- DSM
1 stop8h 24m
American Airlines
Deal found 4/15![American Airlines logo]()
$642
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/262:59 pm
DSM
- MEX
2 stops31h 46m
Multiple Airlines
Wed 4/2911:55 am
MEX
- DSM
1 stop29h 06m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$523
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:01 am
DSM
- CUN
2 stops11h 34m
Delta
Fri 5/159:14 am
CUN
- DSM
2 stops13h 18m
Delta
Deal found 4/12![Delta logo]()
$575
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- GDL
1 stop27h 13m
Multiple Airlines
Mon 5/258:25 pm
GDL
- DSM
2 stops40h 06m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$531
This Aeromexico deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:33 pm
DSM
- PVR
2 stops18h 30m
Aeromexico
Wed 5/136:03 am
PVR
- DSM
2 stops10h 50m
Aeromexico
Deal found 4/14![Aeromexico logo]()
$592
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:20 am
DSM
- MEX
1 stop10h 20m
United Airlines
Wed 6/102:15 pm
MEX
- DSM
1 stop7h 20m
United Airlines
Deal found 4/14![United Airlines logo]()
$620
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/265:10 am
DSM
- CUN
2 stops8h 55m
Southwest
Thu 7/3010:45 am
CUN
- DSM
2 stops11h 35m
Southwest
Deal found 4/14![Southwest logo]()
$638
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:27 am
DSM
- PVR
1 stop8h 04m
Delta
Fri 5/158:48 am
PVR
- DSM
2 stops12h 44m
Delta
Deal found 4/12![Delta logo]()
$592
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:37 pm
DSM
- MEX
2 stops26h 53m
Multiple Airlines
Wed 6/1011:55 am
MEX
- DSM
1 stop30h 51m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$543
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:32 pm
DSM
- PVR
1 stop16h 09m
American Airlines
Sat 10/1011:41 am
PVR
- DSM
1 stop10h 26m
American Airlines
Deal found 4/13![American Airlines logo]()
$672
This Aeromexico deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:33 pm
DSM
- BJX
2 stops19h 16m
Aeromexico
Wed 6/35:48 am
BJX
- DSM
2 stops11h 05m
Aeromexico
Deal found 4/12![Aeromexico logo]()
$615
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:20 am
DSM
- BJX
1 stop5h 31m
United Airlines
Wed 6/35:00 am
BJX
- DSM
1 stop8h 20m
United Airlines
Deal found 4/12![United Airlines logo]()
$620
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:00 am
DSM
- CUN
1 stop6h 00m
Delta
Wed 9/309:30 am
CUN
- DSM
2 stops12h 56m
Delta
Deal found 4/12![Delta logo]()
$593
This Southwest deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:00 am
DSM
- CUN
1 stop8h 35m
Southwest
Sun 5/3112:55 pm
CUN
- DSM
1 stop9h 25m
Southwest
Deal found 4/11![Southwest logo]()
$656
This Aeromexico deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:45 am
DSM
- PVR
1 stop7h 26m
Aeromexico
Fri 10/21:21 pm
PVR
- DSM
1 stop8h 05m
Aeromexico
Deal found 4/16![Aeromexico logo]()
$617
This American Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:13 pm
DSM
- MTY
1 stop17h 32m
American Airlines
Sat 8/15:22 pm
MTY
- DSM
1 stop6h 07m
American Airlines
Deal found 4/12![American Airlines logo]()
$690
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- MTY
1 stop29h 01m
Multiple Airlines
Sun 5/311:15 am
MTY
- DSM
1 stop7h 58m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$575
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:20 am
DSM
- MEX
1 stop10h 20m
United Airlines
Wed 7/222:15 pm
MEX
- DSM
1 stop7h 20m
United Airlines
Deal found 4/12![United Airlines logo]()
$642
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/147:00 am
DSM
- CUN
2 stops13h 32m
Delta
Wed 8/196:03 am
CUN
- DSM
2 stops11h 39m
Delta
Deal found 4/16![Delta logo]()
$593
This Aeromexico deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:27 am
DSM
- BJX
1 stop11h 17m
Aeromexico
Sun 5/319:34 am
BJX
- DSM
1 stop7h 19m
Aeromexico
Deal found 4/13![Aeromexico logo]()
$640
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:30 am
DSM
- BJX
2 stops15h 01m
United Airlines
Sun 5/242:50 pm
BJX
- DSM
1 stop6h 45m
United Airlines
Deal found 4/16![United Airlines logo]()
$645
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/201:49 pm
DSM
- MEX
1 stop8h 56m
Multiple Airlines
Sun 5/318:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$597
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:01 am
DSM
- CUN
2 stops13h 15m
Delta
Thu 6/48:09 am
CUN
- DSM
2 stops14h 23m
Delta
Deal found 4/13![Delta logo]()
$597
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/69:06 am
DSM
- MEX
2 stops9h 44m
United Airlines
Mon 5/182:15 pm
MEX
- DSM
1 stop7h 30m
United Airlines
Deal found 4/12![United Airlines logo]()
$649
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:25 am
DSM
- CUN
1 stop9h 11m
Delta
Sat 7/188:00 am
CUN
- DSM
2 stops12h 49m
Delta
Deal found 4/14![Delta logo]()
$597
Last-minute flights from Des Moines to MexicoDiscover last-minute flight deals from Des Moines to Mexico. Data last updated April 17, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico. Data last updated April 17, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:48 pm
DSM
- MEX
2 stops47h 42m
Multiple Airlines
Sun 5/178:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$474
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:48 pm
DSM
- MEX
2 stops47h 42m
Multiple Airlines
Sat 5/1611:55 am
MEX
- DSM
1 stop29h 06m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$493
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- GDL
1 stop27h 13m
Multiple Airlines
Tue 5/267:13 am
GDL
- DSM
2 stops29h 18m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$501
This Justfly.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- GDL
2 stops24h 18m
Frontier
Tue 5/266:09 am
GDL
- DSM
2 stops30h 22m
Frontier
Deal found 4/14![Frontier logo]()
$508
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:41 pm
DSM
- CUN
1 stop16h 39m
Multiple Airlines
Sun 5/3110:34 am
CUN
- DSM
2 stops26h 57m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$410
This Kiwi.com deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Wed 6/39:05 pm
MEX
- DSM
2 stops23h 22m
Multiple Airlines
Deal found 4/11![Multiple Airlines logo]()
$409
This FlightHub deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- CUN
2 stops24h 13m
Frontier
Tue 6/23:39 pm
CUN
- DSM
1 stop21h 52m
Frontier
Deal found 4/16![Frontier logo]()
$412
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CUN
2 stops21h 26m
Multiple Airlines
Thu 6/410:30 am
CUN
- DSM
1 stop10h 57m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$407
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- MEX
2 stops49h 49m
Multiple Airlines
Thu 6/48:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$487
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Fri 6/511:00 am
MEX
- DSM
1 stop9h 06m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$476
This Expedia deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- CUN
1 stop21h 48m
Frontier
Sun 6/710:30 am
CUN
- DSM
2 stops27h 01m
Frontier
Deal found 4/16![Frontier logo]()
$480
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- MTY
2 stops33h 19m
Multiple Airlines
Fri 6/512:05 pm
MTY
- DSM
1 stop8h 01m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$518
One-way flights from Des Moines to MexicoSearch for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated April 17, 2026.
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated April 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:41 pm
DSM
- CUN
1 stop16h 39m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/62:16 pm
DSM
- GDL
1 stop10h 54m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$178
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:02 pm
DSM
- MTY
2 stops23h 48m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$186
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/152:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2410:14 pm
DSM
- MTY
1 stop22h 06m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- GDL
2 stops34h 04m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- CUN
2 stops23h 51m
Frontier
Deal found 4/13![Frontier logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:02 pm
DSM
- GDL
3 stops27h 49m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/152:16 pm
DSM
- CUN
2 stops19h 35m
Frontier
Deal found 4/14![Frontier logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:02 pm
DSM
- BJX
3 stops31h 13m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$234
Find flight deals from Des Moines to Mexico
Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated April 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $366 (Kiwi.com) |
One-way from | $147 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $582 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMonterrey
DSM - MTY
DSMMTY
Des Moines
Fri 5/29
2:16 pm-10:35 pm
2 stops33h 19m
Monterrey Gen Mariano Escobedo
Fri 6/5
12:05 pm-9:06 pm
1 stop8h 01m
$518
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Sun 4/26
2:59 pm-9:45 pm
2 stops31h 46m
Mexico City Benito Juarez
Wed 4/29
11:55 am-6:01 pm
1 stop29h 06m
$523
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Fri 5/8
2:16 pm-4:29 pm
1 stop27h 13m
Guadalajara Miguel Hidal
Mon 5/25
8:25 pm-1:31 pm
2 stops40h 06m
$531
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Thu 6/4
3:37 pm-5:30 pm
2 stops26h 53m
Mexico City Benito Juarez
Wed 6/10
11:55 am-7:46 pm
1 stop30h 51m
$543
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Sun 6/14
6:20 am-12:02 pm
1 stop5h 42m
Cancun
Thu 6/18
12:55 pm-9:40 pm
1 stop8h 45m
$568
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 7/1
6:07 am-1:05 pm
1 stop6h 58m
Cancun
Wed 7/8
8:00 am-8:49 pm
2 stops12h 49m
$572
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 5/8
7:01 am-6:35 pm
2 stops11h 34m
Cancun
Fri 5/15
9:14 am-10:32 pm
2 stops13h 18m
$575
Des MoinesMonterrey
DSM - MTY
DSMMTY
Des Moines
Fri 5/1
2:04 pm-6:05 pm
1 stop29h 01m
Monterrey Gen Mariano Escobedo
Sun 5/3
11:15 am-8:13 pm
1 stop7h 58m
$575
Des MoinesPuerto Vallarta
DSM - PVR
DSMPVR
Des Moines
Mon 5/11
5:27 am-12:31 pm
1 stop8h 04m
Puerto Vallarta Ordaz
Fri 5/15
1:41 pm-10:32 pm
1 stop7h 51m
$587
Des MoinesPuerto Vallarta
DSM - PVR
DSMPVR
Des Moines
Mon 5/11
2:33 pm-8:03 am
2 stops18h 30m
Puerto Vallarta Ordaz
Wed 5/13
6:03 am-5:53 pm
2 stops10h 50m
$592
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mexico
Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
DSM-CUN
DSM-GDL
DSM-MTY
DSM-MEX
DSM-BJX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico
DSM-MX0
DSM-CUN
DSM-GDL
DSM-MTY
DSM-MEX
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, May is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $192). Flying from Des Moines to Mexico in August is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Mexico
Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated April 17, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Crew
8.6
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Crew
8.6
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Crew
8.6
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Crew
8.6
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Crew
8.6
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Crew
8.6
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mexico
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Complete your trip
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Des Moines and Mexico flights
Browse other Des Moines and Mexico flight options. Last updated on April 17, 2026.
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Des Moines to Mexico flights
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Top 5 airlines flying from Des Moines to Mexico
Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$276 | Average$481 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$366 | Average$687 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$379 | Average$662 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$397 | Average$619 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$547 | Average$697 | FlexibilityNo cancel fee | On-time63% |