HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Mexico

$170+ Cheap flights from Des Moines (DSM) to Mexico

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Mexico with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Mexico

Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated September 16, 2025.

Round-trip from

$353
(American Airlines)

One-way from

$170
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$597
From Des Moines to Mexico
Search Deals
One-way flight from Des Moines to Mexico
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($106 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Des Moines to Mexico

Cheapest flights from Des Moines to Mexico
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/305:04 amDSM - SJD
1 stop12h 21mAmerican Airlines
Thu 11/65:26 pmSJD - DSM
1 stop16h 14mAmerican Airlines
Deal found 9/15$353
This Mytrip deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:56 pmDSM - CUN
2 stops18h 41mMultiple Airlines
Thu 12/111:35 pmCUN - DSM
1 stop9h 46mMultiple Airlines
Deal found 9/14$360
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/152:37 pmDSM - MEX
1 stop27h 23mMultiple Airlines
Wed 10/228:10 amMEX - DSM
1 stop28h 42mMultiple Airlines
Deal found 9/15$368
This Mytrip deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/68:30 amDSM - CUN
2 stops23h 34mMultiple Airlines
Sat 10/119:09 amCUN - DSM
2 stops24h 42mMultiple Airlines
Deal found 9/16$381
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/228:00 amDSM - MEX
1 stop12h 50mMultiple Airlines
Wed 10/298:10 amMEX - DSM
1 stop28h 37mMultiple Airlines
Deal found 9/14$382
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/82:37 pmDSM - GDL
1 stop25h 28mMultiple Airlines
Tue 10/216:00 amGDL - DSM
2 stops30h 52mMultiple Airlines
Deal found 9/16$384
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/31:43 pmDSM - CUN
2 stops18h 21mMultiple Airlines
Sat 11/81:35 pmCUN - DSM
1 stop21h 25mMultiple Airlines
Deal found 9/15$387
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:15 pmDSM - CUN
2 stops36h 17mMultiple Airlines
Thu 12/111:35 pmCUN - DSM
1 stop9h 46mMultiple Airlines
Deal found 9/14$395
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:12 pmDSM - SJD
1 stop16h 58mAmerican Airlines
Sat 11/112:15 pmSJD - DSM
1 stop7h 01mAmerican Airlines
Deal found 9/14$396
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/122:37 pmDSM - GDL
1 stop25h 28mMultiple Airlines
Tue 10/216:00 amGDL - DSM
2 stops30h 52mMultiple Airlines
Deal found 9/16$403
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/28:47 pmDSM - CUN
2 stops15h 57mMultiple Airlines
Wed 11/121:35 pmCUN - DSM
1 stop21h 25mMultiple Airlines
Deal found 9/15$404
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/72:32 pmDSM - CUN
2 stops19h 10mMultiple Airlines
Wed 11/121:35 pmCUN - DSM
1 stop21h 25mMultiple Airlines
Deal found 9/15$407

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.

Fly from

Des Moines

Fly to

Mexico

Route

Depart

Return

Price

Des MoinesSan José del Cabo

DSM - SJD

DSMSJD

Des Moines

Thu 10/30

5:04 am-3:25 pm

1 stop12h 21m

San José del Cabo Los Cabos

Thu 11/6

5:26 pm-10:40 am

1 stop16h 14m

$353

Des MoinesMexico City

DSM - MEX

DSMMEX

Des Moines

Wed 10/15

2:37 pm-5:00 pm

1 stop27h 23m

Mexico City Benito Juarez

Wed 10/22

8:10 am-1:52 pm

1 stop28h 42m

$368

Des MoinesSan José del Cabo

DSM - SJD

DSMSJD

Des Moines

Sat 10/25

6:12 pm-9:10 am

1 stop16h 58m

San José del Cabo Los Cabos

Sat 11/1

12:15 pm-9:16 pm

1 stop7h 01m

$396

Des MoinesSan José del Cabo

DSM - SJD

DSMSJD

Des Moines

Sat 12/6

6:28 pm-12:17 pm

1 stop18h 49m

San José del Cabo Los Cabos

Sat 12/13

2:48 pm-10:59 pm

1 stop7h 11m

$396

Des MoinesSan José del Cabo

DSM - SJD

DSMSJD

Des Moines

Tue 9/23

6:15 am-12:50 pm

1 stop8h 35m

San José del Cabo Los Cabos

Fri 9/26

11:32 am-10:28 pm

1 stop8h 56m

$411

Des MoinesPuerto Vallarta

DSM - PVR

DSMPVR

Des Moines

Tue 10/28

5:00 am-10:15 am

1 stop6h 15m

Puerto Vallarta Ordaz

Tue 11/4

4:32 pm-10:59 pm

1 stop6h 27m

$417

Des MoinesPuerto Vallarta

DSM - PVR

DSMPVR

Des Moines

Sun 1/18

6:48 pm-1:02 pm

2 stops18h 14m

Puerto Vallarta Ordaz

Fri 1/23

3:08 pm-11:44 pm

1 stop8h 36m

$422

Des MoinesPuerto Vallarta

DSM - PVR

DSMPVR

Des Moines

Sat 1/17

3:35 pm-10:47 am

2 stops19h 12m

Puerto Vallarta Ordaz

Fri 1/23

2:00 pm-9:50 pm

1 stop7h 50m

$422

Des MoinesPuerto Vallarta

DSM - PVR

DSMPVR

Des Moines

Sat 3/7

5:59 pm-10:08 am

1 stop16h 09m

Puerto Vallarta Ordaz

Wed 3/11

12:40 pm-9:52 pm

1 stop8h 12m

$422

Des MoinesPuerto Vallarta

DSM - PVR

DSMPVR

Des Moines

Tue 10/21

7:00 am-2:13 pm

1 stop8h 13m

Puerto Vallarta Ordaz

Tue 10/28

1:15 pm-9:00 am

2 stops18h 45m

$422

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Des Moines to Mexico

Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mexico

What is the cheapest month to book a flight from Des Moines to Mexico?

Currently, May is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $387). Flying from Des Moines to Mexico in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to MX?

Find hourly flight availability from Des Moines to Mexico. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Mexico as you normally would.

Reviews of airlines servicing Mexico

Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated September 16, 2025.
See what other customers who have flown with Southwest, Delta, and Aeromexico from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,957 reviews
Southwest
8.0
Very good
4,242 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Aeromexico
7.5
Good
1,696 reviews
Southwest
8.0
Very good
4,242 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,924 reviews
Southwest
8.0
Very good
4,242 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mexico?

    Most people fly from Des Moines (DSM) if they book a flight from Des Moines to Mexico. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.

  • How long is the flight from Des Moines to Mexico?

    American Airlines, United Airlines, and Delta can get you from Des Moines to Mexico in just under 12h 21m. Your travel time can differ by up to 5h 53m. Airlines will cover a distance of 1572 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Des Moines to Mexico one-way?

    For one-way options, check prices for United Airlines. According to our data, you can fly for as low as $185. Users have also found prices from $197 and $246 on American Airlines and Aeromexico, respectively.

  • What are the most popular routes from Des Moines to Mexico?

    Most travelers choose Des Moines - Cancun, Des Moines - Cozumel or Des Moines - San José del Cabo Los Cabos when deciding on the best route from Des Moines to Mexico.

  • Can I find deals for flights from Des Moines to Mexico that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mexico flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mexico?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mexico.

  • Can I find deals for business class flights from Des Moines to Mexico?

    Yes. Cheapflights offers flight deals from Des Moines to Mexico by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mexico?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $387). Flying from Des Moines to Mexico in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Mexico

See prices for flight routes from nearby airports that may be better suited for you.
Omaha to LaGuardia flights
Cedar Rapids to Denver flights
Omaha to Denver flights
Omaha to Seattle flights
Des Moines to Denver flights
Des Moines to Sky Harbor Intl flights
Omaha to Las Vegas flights
Des Moines to Cancún flights
Omaha to Dallas/Fort Worth flights
Omaha to Orlando flights
Des Moines to Las Vegas flights
Cedar Rapids to Dallas/Fort Worth flights
Omaha to Sky Harbor Intl flights
Des Moines to Dallas/Fort Worth flights
Omaha to John F Kennedy Intl flights
Des Moines to LaGuardia flights
Omaha to Los Angeles flights
Cedar Rapids to Sky Harbor Intl flights
Cedar Rapids to Orlando flights
Cedar Rapids to John F Kennedy Intl flights
Des Moines to John F Kennedy Intl flights
Omaha to Cancún flights
Omaha to Hobby flights
Omaha to Newark flights
Cedar Rapids to LaGuardia flights
Omaha to O'Hare Intl flights
Cedar Rapids to Cancún flights
Des Moines to Orlando flights
Des Moines to Cozumel flights
Cedar Rapids to Las Vegas flights
Des Moines to Hobby flights
Des Moines to Los Angeles flights
Omaha to Atlanta flights
Omaha to Miami flights
Moline to Dallas/Fort Worth flights
Omaha to San Diego flights
Moline to Denver flights
Moline to Orlando flights
Cedar Rapids to Newark flights
Des Moines to Miami flights
Omaha to George Bush Intcntl flights
Omaha to Nashville flights
Des Moines to George Bush Intcntl flights
Omaha to Reagan-National flights
Omaha to Love Field flights
Des Moines to Seattle flights
Des Moines to Reagan-National flights
Omaha to Dulles Intl flights
Des Moines to Tampa flights
Omaha to Honolulu flights

Top 5 airlines flying from Des Moines to Mexico

Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$250Average$600FlexibilityNo cancel feeOn-timeN/A
AeromexicoCheapest$350Average$500FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$423Average$647FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$423Average$653FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$460Average$658FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.