$147+ Cheap flights from Des Moines (DSM) to Mexico
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
May 18 — May 251
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 18, 2026.
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/124:57 pm
DSM
- CUN
1 stop16h 18m
Multiple Airlines
Thu 7/1610:25 am
CUN
- DSM
1 stop11h 02m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$366
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:37 pm
DSM
- CUN
2 stops20h 27m
Multiple Airlines
Thu 6/1110:25 am
CUN
- DSM
1 stop11h 02m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$403
This FlightHub deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- CUN
2 stops24h 13m
Frontier
Tue 6/23:39 pm
CUN
- DSM
1 stop21h 52m
Frontier
Deal found 4/16![Frontier logo]()
$412
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CUN
2 stops21h 26m
Multiple Airlines
Thu 6/410:30 am
CUN
- DSM
1 stop10h 57m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$413
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/264:57 pm
DSM
- CUN
1 stop16h 18m
Multiple Airlines
Thu 7/303:35 pm
CUN
- DSM
1 stop21h 56m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$419
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:48 pm
DSM
- MEX
2 stops47h 42m
Multiple Airlines
Sun 5/178:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$474
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Fri 6/511:00 am
MEX
- DSM
1 stop9h 06m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$476
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- MEX
2 stops49h 49m
Multiple Airlines
Thu 6/48:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$487
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:48 pm
DSM
- MEX
2 stops47h 42m
Multiple Airlines
Sat 5/1611:55 am
MEX
- DSM
1 stop29h 06m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$493
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- GDL
1 stop27h 13m
Multiple Airlines
Tue 5/267:13 am
GDL
- DSM
2 stops29h 18m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$501
This Justfly.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- GDL
2 stops24h 18m
Frontier
Tue 5/266:09 am
GDL
- DSM
2 stops30h 22m
Frontier
Deal found 4/14![Frontier logo]()
$508
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:37 pm
DSM
- MTY
2 stops27h 03m
Multiple Airlines
Fri 6/1212:05 pm
MTY
- DSM
1 stop8h 01m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$508
Best flights from Des Moines to MexicoDiscover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 18, 2026.
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 18, 2026.
This Frontier deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/122:16 pm
DSM
- GDL
1 stop11h 16m
Frontier
Tue 6/168:59 pm
GDL
- DSM
2 stops15h 32m
Frontier
Deal found 4/13![Frontier logo]()
$501
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- MTY
2 stops33h 19m
Multiple Airlines
Fri 6/512:05 pm
MTY
- DSM
1 stop8h 01m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$518
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:26 am
DSM
- CUN
2 stops9h 50m
Delta
Tue 6/28:00 am
CUN
- DSM
2 stops12h 36m
Delta
Deal found 4/13![Delta logo]()
$554
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:30 am
DSM
- CUN
1 stop7h 28m
United Airlines
Tue 5/193:38 pm
CUN
- DSM
1 stop7h 46m
United Airlines
Deal found 4/15![United Airlines logo]()
$572
This Aeromexico deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:33 pm
DSM
- PVR
2 stops18h 30m
Aeromexico
Wed 5/136:03 am
PVR
- DSM
2 stops10h 50m
Aeromexico
Deal found 4/14![Aeromexico logo]()
$592
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/265:10 am
DSM
- CUN
2 stops11h 00m
Southwest
Thu 7/212:40 pm
CUN
- DSM
2 stops10h 50m
Southwest
Deal found 4/17![Southwest logo]()
$597
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/115:37 am
DSM
- SJD
1 stop7h 13m
American Airlines
Fri 10/161:25 pm
SJD
- DSM
1 stop8h 24m
American Airlines
Deal found 4/15![American Airlines logo]()
$642
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- MTY
1 stop28h 49m
Multiple Airlines
Mon 6/85:20 pm
MTY
- DSM
2 stops43h 11m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$520
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/146:07 am
DSM
- CUN
1 stop6h 58m
Delta
Thu 6/1812:36 pm
CUN
- DSM
1 stop8h 16m
Delta
Deal found 4/17![Delta logo]()
$568
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:15 am
DSM
- CUN
1 stop6h 55m
United Airlines
Sat 5/2312:11 pm
CUN
- DSM
1 stop9h 29m
United Airlines
Deal found 4/13![United Airlines logo]()
$575
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- GDL
1 stop27h 13m
Multiple Airlines
Mon 5/258:25 pm
GDL
- DSM
2 stops40h 06m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$531
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1810:26 am
DSM
- CUN
2 stops9h 50m
Delta
Sat 5/2312:45 pm
CUN
- DSM
1 stop7h 37m
Delta
Deal found 4/13![Delta logo]()
$579
This Aeromexico deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2911:04 am
DSM
- BJX
2 stops21h 09m
Aeromexico
Wed 9/25:55 am
BJX
- DSM
2 stops10h 47m
Aeromexico
Deal found 4/17![Aeromexico logo]()
$640
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:32 am
DSM
- PVR
1 stop26h 04m
American Airlines
Sat 9/122:00 pm
PVR
- DSM
2 stops18h 10m
American Airlines
Deal found 4/15![American Airlines logo]()
$652
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:20 am
DSM
- MEX
1 stop10h 20m
United Airlines
Wed 6/102:15 pm
MEX
- DSM
1 stop7h 20m
United Airlines
Deal found 4/14![United Airlines logo]()
$620
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- MTY
1 stop29h 01m
Multiple Airlines
Sun 5/311:15 am
MTY
- DSM
1 stop7h 58m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$575
This Aeromexico deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/282:15 pm
DSM
- PVR
2 stops20h 25m
Aeromexico
Fri 10/21:21 pm
PVR
- DSM
1 stop8h 05m
Aeromexico
Deal found 4/17![Aeromexico logo]()
$642
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:01 am
DSM
- CUN
2 stops13h 15m
Delta
Fri 5/158:00 am
CUN
- DSM
1 stop14h 32m
Delta
Deal found 4/15![Delta logo]()
$589
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:10 am
DSM
- PVR
2 stops10h 50m
Southwest
Sat 7/1110:45 am
PVR
- DSM
2 stops11h 05m
Southwest
Deal found 4/17![Southwest logo]()
$727
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:32 pm
DSM
- PVR
1 stop16h 09m
American Airlines
Sat 10/1011:41 am
PVR
- DSM
1 stop10h 26m
American Airlines
Deal found 4/17![American Airlines logo]()
$667
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/289:34 pm
DSM
- MEX
1 stop25h 11m
Multiple Airlines
Thu 6/48:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$578
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:30 am
DSM
- BJX
2 stops15h 01m
United Airlines
Sun 5/242:50 pm
BJX
- DSM
1 stop6h 45m
United Airlines
Deal found 4/16![United Airlines logo]()
$645
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:00 am
DSM
- CUN
1 stop6h 00m
Delta
Wed 9/308:00 am
CUN
- DSM
2 stops14h 26m
Delta
Deal found 4/17![Delta logo]()
$593
This Aeromexico deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:00 pm
DSM
- PVR
2 stops17h 03m
Aeromexico
Thu 5/288:48 am
PVR
- DSM
2 stops12h 44m
Aeromexico
Deal found 4/16![Aeromexico logo]()
$672
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:19 pm
DSM
- SJD
1 stop17h 54m
American Airlines
Sat 5/3011:38 am
SJD
- DSM
1 stop10h 39m
American Airlines
Deal found 4/13![American Airlines logo]()
$717
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:00 am
DSM
- MTY
1 stop7h 41m
United Airlines
Fri 6/123:58 pm
MTY
- DSM
1 stop5h 37m
United Airlines
Deal found 4/17![United Airlines logo]()
$656
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:25 am
DSM
- CUN
1 stop9h 11m
Delta
Sat 7/188:00 am
CUN
- DSM
2 stops12h 49m
Delta
Deal found 4/14![Delta logo]()
$597
This Aeromexico deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:27 am
DSM
- BJX
1 stop11h 17m
Aeromexico
Sun 5/177:15 pm
BJX
- DSM
2 stops21h 38m
Aeromexico
Deal found 4/14![Aeromexico logo]()
$710
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:20 am
DSM
- MTY
1 stop5h 28m
United Airlines
Mon 7/2712:10 pm
MTY
- DSM
1 stop9h 25m
United Airlines
Deal found 4/15![United Airlines logo]()
$656
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2810:56 am
DSM
- CUN
2 stops9h 20m
Delta
Thu 6/48:09 am
CUN
- DSM
2 stops14h 23m
Delta
Deal found 4/13![Delta logo]()
$597
Last-minute flights from Des Moines to MexicoDiscover last-minute flight deals from Des Moines to Mexico. Data last updated April 18, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico. Data last updated April 18, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:48 pm
DSM
- MEX
2 stops47h 42m
Multiple Airlines
Sun 5/178:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$474
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:48 pm
DSM
- MEX
2 stops47h 42m
Multiple Airlines
Sat 5/1611:55 am
MEX
- DSM
1 stop29h 06m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$493
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- GDL
1 stop27h 13m
Multiple Airlines
Tue 5/267:13 am
GDL
- DSM
2 stops29h 18m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$501
This Justfly.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- GDL
2 stops24h 18m
Frontier
Tue 5/266:09 am
GDL
- DSM
2 stops30h 22m
Frontier
Deal found 4/14![Frontier logo]()
$508
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/911:00 am
DSM
- MEX
2 stops35h 45m
Multiple Airlines
Sat 5/1611:55 am
MEX
- DSM
1 stop29h 06m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$511
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:45 am
DSM
- CUN
1 stop27h 32m
Multiple Airlines
Sun 5/2410:30 am
CUN
- DSM
2 stops27h 01m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$485
This FlightHub deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- CUN
2 stops24h 13m
Frontier
Tue 6/23:39 pm
CUN
- DSM
1 stop21h 52m
Frontier
Deal found 4/16![Frontier logo]()
$412
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CUN
2 stops21h 26m
Multiple Airlines
Thu 6/410:30 am
CUN
- DSM
1 stop10h 57m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$413
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- MEX
2 stops49h 49m
Multiple Airlines
Thu 6/48:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$487
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Fri 6/511:00 am
MEX
- DSM
1 stop9h 06m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$476
This Expedia deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- CUN
1 stop21h 48m
Frontier
Sun 6/710:30 am
CUN
- DSM
2 stops27h 01m
Frontier
Deal found 4/16![Frontier logo]()
$480
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- GDL
1 stop27h 13m
Multiple Airlines
Fri 6/58:46 am
GDL
- DSM
1 stop11h 20m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$522
One-way flights from Des Moines to MexicoSearch for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated April 18, 2026.
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated April 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:41 pm
DSM
- CUN
1 stop16h 39m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/62:16 pm
DSM
- GDL
1 stop10h 54m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$178
This Priceline deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:16 pm
DSM
- MEX
1 stop28h 14m
Frontier
Deal found 4/18![Frontier logo]()
$183
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:02 pm
DSM
- MTY
2 stops23h 48m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$186
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2410:14 pm
DSM
- MTY
1 stop22h 06m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:37 pm
DSM
- MTY
2 stops27h 03m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:01 pm
DSM
- MEX
1 stop24h 44m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- GDL
2 stops34h 04m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:17 pm
DSM
- GDL
2 stops27h 42m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/163:37 pm
DSM
- MEX
2 stops52h 08m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$227
Find flight deals from Des Moines to Mexico
Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated April 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $366 (Kiwi.com) |
One-way from | $147 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $582 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Fri 6/12
2:16 pm-12:32 am
1 stop11h 16m
Guadalajara Miguel Hidal
Tue 6/16
8:59 pm-1:31 pm
2 stops15h 32m
$501
Des MoinesMonterrey
DSM - MTY
DSMMTY
Des Moines
Fri 5/29
2:16 pm-10:35 pm
2 stops33h 19m
Monterrey Gen Mariano Escobedo
Fri 6/5
12:05 pm-9:06 pm
1 stop8h 01m
$518
Des MoinesMonterrey
DSM - MTY
DSMMTY
Des Moines
Mon 6/1
2:16 pm-6:05 pm
1 stop28h 49m
Monterrey Gen Mariano Escobedo
Mon 6/8
5:20 pm-1:31 pm
2 stops43h 11m
$520
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Fri 5/8
2:16 pm-4:29 pm
1 stop27h 13m
Guadalajara Miguel Hidal
Mon 5/25
8:25 pm-1:31 pm
2 stops40h 06m
$531
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 5/27
10:26 am-8:16 pm
2 stops9h 50m
Cancun
Tue 6/2
8:00 am-8:36 pm
2 stops12h 36m
$554
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Sun 6/14
6:07 am-1:05 pm
1 stop6h 58m
Cancun
Thu 6/18
12:36 pm-8:52 pm
1 stop8h 16m
$568
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Tue 5/5
5:30 am-12:58 pm
1 stop7h 28m
Cancun
Tue 5/19
3:38 pm-11:24 pm
1 stop7h 46m
$572
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Mon 5/18
6:15 am-1:10 pm
1 stop6h 55m
Cancun
Sat 5/23
12:11 pm-9:40 pm
1 stop9h 29m
$575
Des MoinesMonterrey
DSM - MTY
DSMMTY
Des Moines
Fri 5/1
2:04 pm-6:05 pm
1 stop29h 01m
Monterrey Gen Mariano Escobedo
Sun 5/3
11:15 am-8:13 pm
1 stop7h 58m
$575
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Thu 5/28
9:34 pm-9:45 pm
1 stop25h 11m
Mexico City Benito Juarez
Thu 6/4
8:40 am-1:31 pm
1 stop27h 51m
$578
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mexico
Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
DSM-CUN
DSM-MEX
DSM-GDL
DSM-MTY
DSM-PVR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico
DSM-MX0
DSM-CUN
DSM-MEX
DSM-GDL
DSM-MTY
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, May is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $192). Flying from Des Moines to Mexico in August is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Mexico
Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated April 18, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mexico
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Complete your trip
Complete your trip to Mexico by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and Mexico flights
Browse other Des Moines and Mexico flight options. Last updated on April 18, 2026.
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Des Moines to Mexico flights
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Consider these flights traveling to Mexico regions.
Top 5 airlines flying from Des Moines to Mexico
Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$276 | Average$481 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$366 | Average$687 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$379 | Average$662 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$397 | Average$619 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$547 | Average$697 | FlexibilityNo cancel fee | On-time63% |