$142+ Cheap flights from Des Moines (DSM) to Mexico
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
Apr 9 — Apr 161
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to Mexico with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Mexico
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2010:15 am
DSM
- CUN
1 stop28h 18m
Frontier
Tue 3/2412:16 pm
CUN
- DSM
2 stops31h 00m
Frontier
Deal found 3/6![Frontier logo]()
$375
This FlightHub deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/188:21 pm
DSM
- CUN
1 stop14h 55m
Frontier
Wed 3/259:53 am
CUN
- DSM
1 stop9h 23m
Frontier
Deal found 3/6![Frontier logo]()
$380
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:00 am
DSM
- CUN
1 stop6h 05m
American Airlines
Tue 4/2811:52 am
CUN
- DSM
1 stop11h 57m
American Airlines
Deal found 3/8![American Airlines logo]()
$387
This Bravofly deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Bravofly is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/212:44 pm
DSM
- CUN
2 stops19h 36m
Aeromexico
Tue 4/286:00 am
CUN
- DSM
2 stops11h 45m
Aeromexico
Deal found 3/7![Aeromexico logo]()
$393
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/192:59 pm
DSM
- MEX
2 stops40h 41m
Multiple Airlines
Sun 4/268:40 am
MEX
- DSM
1 stop27h 29m
Multiple Airlines
Deal found 3/7![Multiple Airlines logo]()
$397
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/192:59 pm
DSM
- MEX
2 stops40h 41m
Multiple Airlines
Thu 4/308:40 am
MEX
- DSM
1 stop27h 29m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$423
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:04 pm
DSM
- MEX
2 stops32h 26m
Multiple Airlines
Sun 4/268:40 am
MEX
- DSM
1 stop27h 29m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$424
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/311:00 am
DSM
- GDL
1 stop8h 30m
Multiple Airlines
Tue 5/197:10 am
GDL
- DSM
2 stops28h 49m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$426
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:56 pm
DSM
- CUN
1 stop13h 05m
Frontier
Mon 3/2310:08 am
CUN
- DSM
1 stop9h 08m
Frontier
Deal found 3/6![Frontier logo]()
$428
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/192:59 pm
DSM
- MTY
1 stop24h 56m
Multiple Airlines
Sun 4/266:00 am
MTY
- DSM
2 stops30h 09m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$430
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:20 pm
DSM
- SJD
1 stop20h 25m
American Airlines
Fri 4/172:59 pm
SJD
- DSM
1 stop7h 00m
American Airlines
Deal found 3/5![American Airlines logo]()
$435
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:04 pm
DSM
- MEX
1 stop28h 26m
Multiple Airlines
Fri 5/16:50 am
MEX
- DSM
2 stops13h 34m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$444
Best flights from Des Moines to MexicoDiscover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 10, 2026.
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 10, 2026.
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/137:05 pm
DSM
- PVR
1 stop17h 14m
American Airlines
Fri 4/1711:22 am
PVR
- DSM
1 stop11h 37m
American Airlines
Deal found 3/5![American Airlines logo]()
$454
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:33 pm
DSM
- CUN
1 stop5h 43m
Delta
Fri 5/158:00 am
CUN
- DSM
1 stop9h 54m
Delta
Deal found 3/7![Delta logo]()
$468
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/58:15 am
DSM
- SJD
1 stop6h 33m
United Airlines
Tue 5/1211:32 am
SJD
- DSM
1 stop9h 13m
United Airlines
Deal found 3/8![United Airlines logo]()
$492
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:04 pm
DSM
- MEX
1 stop28h 26m
Multiple Airlines
Fri 5/16:50 am
MEX
- DSM
2 stops13h 34m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$493
This Aeromexico deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:55 am
DSM
- SJD
1 stop7h 32m
Aeromexico
Wed 4/86:00 am
SJD
- DSM
2 stops14h 38m
Aeromexico
Deal found 3/5![Aeromexico logo]()
$547
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:45 am
DSM
- CUN
2 stops10h 53m
Delta
Tue 4/288:06 am
CUN
- DSM
2 stops14h 28m
Delta
Deal found 3/8![Delta logo]()
$492
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:15 am
DSM
- CUN
1 stop6h 55m
United Airlines
Fri 5/82:49 pm
CUN
- DSM
1 stop7h 56m
United Airlines
Deal found 3/5![United Airlines logo]()
$492
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1911:00 am
DSM
- GDL
1 stop8h 30m
Multiple Airlines
Sun 4/265:50 am
GDL
- DSM
2 stops30h 19m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$511
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:20 pm
DSM
- MLM
1 stop22h 09m
American Airlines
Tue 4/281:19 pm
MLM
- DSM
1 stop21h 07m
American Airlines
Deal found 3/7![American Airlines logo]()
$544
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:30 am
DSM
- PVR
1 stop8h 23m
United Airlines
Tue 4/141:55 pm
PVR
- DSM
1 stop8h 47m
United Airlines
Deal found 3/8![United Airlines logo]()
$512
This Aeromexico deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2011:51 am
DSM
- BJX
2 stops21h 44m
Aeromexico
Mon 4/277:45 pm
BJX
- DSM
2 stops25h 49m
Aeromexico
Deal found 3/7![Aeromexico logo]()
$588
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:00 am
DSM
- SJD
2 stops12h 48m
Delta
Sat 5/96:07 am
SJD
- DSM
2 stops14h 25m
Delta
Deal found 3/9![Delta logo]()
$537
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/78:36 pm
DSM
- GDL
1 stop22h 39m
Multiple Airlines
Wed 6/2411:09 am
GDL
- DSM
2 stops31h 37m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$538
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:06 pm
DSM
- GDL
1 stop11h 53m
American Airlines
Thu 4/301:29 pm
GDL
- DSM
1 stop24h 18m
American Airlines
Deal found 3/9![American Airlines logo]()
$551
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/88:20 am
DSM
- SJD
1 stop6h 28m
United Airlines
Sat 4/112:50 pm
SJD
- DSM
1 stop6h 52m
United Airlines
Deal found 3/8![United Airlines logo]()
$537
This Aeromexico deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/205:45 am
DSM
- MTY
1 stop13h 05m
Aeromexico
Mon 4/279:55 pm
MTY
- DSM
2 stops18h 50m
Aeromexico
Deal found 3/6![Aeromexico logo]()
$597
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:20 pm
DSM
- GDL
1 stop22h 09m
American Airlines
Tue 4/285:36 am
GDL
- DSM
1 stop8h 11m
American Airlines
Deal found 3/7![American Airlines logo]()
$553
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/267:30 am
DSM
- GDL
1 stop10h 11m
Multiple Airlines
Sun 4/58:30 am
GDL
- DSM
2 stops33h 44m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$586
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/72:15 pm
DSM
- MEX
2 stops21h 30m
Delta
Thu 7/166:10 pm
MEX
- DSM
2 stops18h 12m
Delta
Deal found 3/7![Delta logo]()
$587
This Aeromexico deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1511:51 am
DSM
- MEX
1 stop8h 49m
Aeromexico
Mon 4/208:00 pm
MEX
- DSM
2 stops25h 34m
Aeromexico
Deal found 3/5![Aeromexico logo]()
$606
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/218:20 am
DSM
- CZM
1 stop7h 22m
United Airlines
Tue 4/283:52 pm
CZM
- DSM
1 stop5h 51m
United Airlines
Deal found 3/6![United Airlines logo]()
$551
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/205:00 am
DSM
- MID
1 stop9h 36m
American Airlines
Mon 4/272:26 pm
MID
- DSM
1 stop26h 17m
American Airlines
Deal found 3/7![American Airlines logo]()
$554
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:55 am
DSM
- SJD
2 stops13h 44m
Delta
Wed 4/810:49 am
SJD
- DSM
1 stop8h 21m
Delta
Deal found 3/10![Delta logo]()
$603
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:30 am
DSM
- SJD
2 stops9h 18m
United Airlines
Sat 4/251:44 pm
SJD
- DSM
1 stop6h 59m
United Airlines
Deal found 3/9![United Airlines logo]()
$557
This Aeromexico deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/205:45 am
DSM
- GDL
1 stop6h 52m
Aeromexico
Mon 4/278:50 pm
GDL
- DSM
2 stops24h 44m
Aeromexico
Deal found 3/7![Aeromexico logo]()
$614
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:05 pm
DSM
- PVR
2 stops20h 05m
American Airlines
Sat 5/161:29 pm
PVR
- DSM
1 stop9h 30m
American Airlines
Deal found 3/8![American Airlines logo]()
$562
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/115:45 am
DSM
- MEX
1 stop16h 29m
Delta
Wed 7/159:00 am
MEX
- DSM
2 stops12h 26m
Delta
Deal found 3/7![Delta logo]()
$607
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:16 pm
DSM
- PVR
2 stops16h 54m
United Airlines
Fri 5/11:55 pm
PVR
- DSM
1 stop8h 49m
United Airlines
Deal found 3/10![United Airlines logo]()
$557
This Aeromexico deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/235:45 am
DSM
- GDL
2 stops26h 54m
Aeromexico
Thu 4/309:56 pm
GDL
- DSM
2 stops18h 49m
Aeromexico
Deal found 3/9![Aeromexico logo]()
$617
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/203:20 pm
DSM
- MTY
1 stop20h 20m
American Airlines
Mon 4/274:49 pm
MTY
- DSM
1 stop20h 58m
American Airlines
Deal found 3/6![American Airlines logo]()
$570
Last-minute flights from Des Moines to MexicoDiscover last-minute flight deals from Des Moines to Mexico. Data last updated March 10, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico. Data last updated March 10, 2026 and is based on user searches.
This FlightHub deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/188:21 pm
DSM
- CUN
1 stop14h 55m
Frontier
Wed 3/259:53 am
CUN
- DSM
1 stop9h 23m
Frontier
Deal found 3/6![Frontier logo]()
$380
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2010:15 am
DSM
- CUN
1 stop28h 18m
Frontier
Tue 3/2412:16 pm
CUN
- DSM
2 stops31h 00m
Frontier
Deal found 3/6![Frontier logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2111:43 am
DSM
- MEX
1 stop9h 22m
Multiple Airlines
Wed 3/256:40 am
MEX
- DSM
2 stops29h 49m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$447
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:20 pm
DSM
- SJD
1 stop20h 25m
American Airlines
Fri 4/172:59 pm
SJD
- DSM
1 stop7h 00m
American Airlines
Deal found 3/5![American Airlines logo]()
$435
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/192:59 pm
DSM
- MEX
2 stops40h 41m
Multiple Airlines
Sun 4/268:40 am
MEX
- DSM
1 stop27h 29m
Multiple Airlines
Deal found 3/7![Multiple Airlines logo]()
$397
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/192:59 pm
DSM
- MEX
2 stops40h 41m
Multiple Airlines
Thu 4/308:40 am
MEX
- DSM
1 stop27h 29m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$423
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/192:59 pm
DSM
- MTY
1 stop24h 56m
Multiple Airlines
Sun 4/266:00 am
MTY
- DSM
2 stops30h 09m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$430
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:04 pm
DSM
- MEX
2 stops32h 26m
Multiple Airlines
Sun 4/268:40 am
MEX
- DSM
1 stop27h 29m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$424
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:04 pm
DSM
- MEX
1 stop28h 26m
Multiple Airlines
Thu 4/308:40 am
MEX
- DSM
1 stop27h 29m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$449
This Bravofly deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Bravofly is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:45 am
DSM
- PVR
2 stops14h 30m
Aeromexico
Tue 4/286:00 am
PVR
- DSM
2 stops15h 34m
Aeromexico
Deal found 3/7![Aeromexico logo]()
$444
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:56 pm
DSM
- SJD
1 stop17h 36m
American Airlines
Tue 4/2812:41 pm
SJD
- DSM
1 stop20h 45m
American Airlines
Deal found 3/7![American Airlines logo]()
$451
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:04 pm
DSM
- MEX
1 stop28h 26m
Multiple Airlines
Fri 5/16:50 am
MEX
- DSM
2 stops13h 34m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$444
One-way flights from Des Moines to MexicoSearch for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated March 10, 2026.
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated March 10, 2026.
This Trip.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:56 pm
DSM
- CUN
1 stop13h 05m
Frontier
Deal found 3/6![Frontier logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2210:55 am
DSM
- MEX
1 stop9h 50m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$159
This Travelocity deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/258:21 pm
DSM
- CUN
1 stop14h 55m
Frontier
Deal found 3/6![Frontier logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/303:02 pm
DSM
- MEX
1 stop30h 03m
Multiple Airlines
Deal found 3/7![Multiple Airlines logo]()
$177
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/102:51 pm
DSM
- PVR
2 stops42h 24m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/810:01 pm
DSM
- GDL
2 stops31h 54m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$203
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/126:00 am
DSM
- CUN
1 stop7h 52m
American Airlines
Deal found 3/7![American Airlines logo]()
$210
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/126:15 am
DSM
- CUN
2 stops13h 59m
Delta
Deal found 3/7![Delta logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:56 pm
DSM
- CUN
2 stops18h 38m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/203:32 pm
DSM
- SJD
3 stops44h 37m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$218
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/205:30 am
DSM
- SJD
2 stops9h 18m
United Airlines
Deal found 3/9![United Airlines logo]()
$224
This Priceline deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:21 pm
DSM
- CUN
1 stop21h 40m
Frontier
Deal found 3/7![Frontier logo]()
$226
Find flight deals from Des Moines to Mexico
Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated March 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $375 (Kiwi.com) |
One-way from | $142 (Trip.com) |
Popular in | December |
Cheapest in | August |
Average price | $549 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesPuerto Vallarta
DSM - PVR
DSMPVR
Des Moines
Mon 4/13
7:05 pm-11:19 am
1 stop17h 14m
Puerto Vallarta Ordaz
Fri 4/17
11:22 am-11:59 pm
1 stop11h 37m
$454
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 5/8
2:33 pm-8:16 pm
1 stop5h 43m
Cancun
Fri 5/15
8:00 am-5:54 pm
1 stop9h 54m
$468
Des MoinesSan José del Cabo
DSM - SJD
DSMSJD
Des Moines
Tue 5/5
8:15 am-12:48 pm
1 stop6h 33m
San José del Cabo Los Cabos
Tue 5/12
11:32 am-10:45 pm
1 stop9h 13m
$492
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Tue 4/21
5:45 am-4:38 pm
2 stops10h 53m
Cancun
Tue 4/28
8:06 am-10:34 pm
2 stops14h 28m
$492
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 5/1
6:15 am-1:10 pm
1 stop6h 55m
Cancun
Fri 5/8
2:49 pm-10:45 pm
1 stop7h 56m
$492
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Fri 4/24
2:04 pm-5:30 pm
1 stop28h 26m
Mexico City Benito Juarez
Fri 5/1
6:50 am-9:24 pm
2 stops13h 34m
$493
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Sun 4/19
11:00 am-6:30 pm
1 stop8h 30m
Guadalajara Miguel Hidal
Sun 4/26
5:50 am-1:09 pm
2 stops30h 19m
$511
Des MoinesPuerto Vallarta
DSM - PVR
DSMPVR
Des Moines
Tue 4/7
5:30 am-12:53 pm
1 stop8h 23m
Puerto Vallarta Ordaz
Tue 4/14
1:55 pm-11:42 pm
1 stop8h 47m
$512
Des MoinesSan José del Cabo
DSM - SJD
DSMSJD
Des Moines
Wed 5/6
7:00 am-5:48 pm
2 stops12h 48m
San José del Cabo Los Cabos
Sat 5/9
6:07 am-10:32 pm
2 stops14h 25m
$537
Des MoinesSan José del Cabo
DSM - SJD
DSMSJD
Des Moines
Wed 4/8
8:20 am-12:48 pm
1 stop6h 28m
San José del Cabo Los Cabos
Sat 4/11
2:50 pm-11:42 pm
1 stop6h 52m
$537
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mexico
Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
DSM-MEX
DSM-CUN
DSM-SJD
DSM-PVR
DSM-MLM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico
DSM-MX0
DSM-MEX
DSM-CUN
DSM-SJD
DSM-PVR
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, October is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $241). Flying from Des Moines to Mexico in June is currently the most expensive (average of $468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Mexico
Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated March 10, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Top regions
Alternative routes for Des Moines to Mexico
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Mexico by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Mexico by cabin class
Find flights from Des Moines to Mexico, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Mexico flights
Browse other Des Moines and Mexico flight options. Last updated on March 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to Mexico flights
Consider these flights traveling from Des Moines to Mexico.
Fly to Mexico regions
Consider these flights traveling to Mexico regions.
Top 5 airlines flying from Des Moines to Mexico
Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$233 | Average$480 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$366 | Average$651 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$373 | Average$605 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$379 | Average$651 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$569 | Average$694 | FlexibilityNo cancel fee | On-time63% |