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$151+ Cheap flights from Des Moines (DSM) to Mexico

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
Aug 21 — Aug 281
Thu 8/21
Thu 8/28
1 adult, Economy
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Cheap flight deals from Des Moines to Mexico

Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated August 16, 2025.

Round-trip from

$355
(Delta)

One-way from

$151
(American Airlines)

Popular in

December

Cheapest in

August

Average price

$537
From Des Moines to Mexico
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One-way flight from Des Moines to Mexico
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Highest demand for flights based on searches. 12% potential increase in price ($88 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Des Moines to Mexico

Cheapest flights from Des Moines to Mexico
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 16, 2025.

This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/177:00 amDSM - SJD
2 stops14h 23mDelta
Wed 9/246:01 amSJD - DSM
2 stops14h 36mDelta
Deal found 8/14$355
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/276:12 pmDSM - SJD
1 stop16h 58mAmerican Airlines
Sat 10/41:17 pmSJD - DSM
1 stop7h 56mAmerican Airlines
Deal found 8/13$371
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/75:11 amDSM - CUN
1 stop9h 52mAmerican Airlines
Thu 9/112:50 pmCUN - DSM
1 stop9h 25mAmerican Airlines
Deal found 8/15$376
This Mytrip deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/33:40 pmDSM - CUN
2 stops17h 35mMultiple Airlines
Wed 10/89:09 amCUN - DSM
1 stop12h 36mMultiple Airlines
Deal found 8/15$379
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/119:19 amDSM - CUN
1 stop22h 45mMultiple Airlines
Thu 10/169:09 amCUN - DSM
1 stop23h 21mMultiple Airlines
Deal found 8/14$380
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/197:03 amDSM - SJD
2 stops14h 25mDelta
Sat 10/256:00 amSJD - DSM
2 stops14h 30mDelta
Deal found 8/13$383
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/278:16 amDSM - PVR
1 stop29h 09mAmerican Airlines
Sat 10/411:01 amPVR - DSM
1 stop11h 12mAmerican Airlines
Deal found 8/13$392
This Mytrip deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/245:49 pmDSM - CUN
2 stops18h 55mMultiple Airlines
Tue 10/281:49 pmCUN - DSM
2 stops20h 40mMultiple Airlines
Deal found 8/15$394
This SmartFares deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/75:44 amDSM - CUN
1 stop7h 06mAeromexico
Thu 9/112:00 pmCUN - DSM
1 stop8h 37mAeromexico
Deal found 8/14$395
This Mytrip deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/75:49 pmDSM - CUN
2 stops19h 10mMultiple Airlines
Thu 9/1112:52 pmCUN - DSM
3 stops24h 30mMultiple Airlines
Deal found 8/15$398
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/285:11 amDSM - PVR
1 stop5h 50mAmerican Airlines
Sun 10/511:01 amPVR - DSM
1 stop11h 29mAmerican Airlines
Deal found 8/14$401
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/85:10 amDSM - PVR
1 stop8h 12mAmerican Airlines
Sat 9/131:22 pmPVR - DSM
1 stop8h 51mAmerican Airlines
Deal found 8/13$437

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2025.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.

Fly from

Des Moines

Fly to

Mexico

Route

Depart

Return

Price

Des MoinesSan José del Cabo

DSM - SJD

DSMSJD

Des Moines

Wed 9/17

7:00 am-7:23 pm

2 stops14h 23m

San José del Cabo Los Cabos

Wed 9/24

12:30 pm-10:37 pm

1 stop8h 07m

$355

Des MoinesSan José del Cabo

DSM - SJD

DSMSJD

Des Moines

Sat 9/27

6:12 pm-9:10 am

1 stop16h 58m

San José del Cabo Los Cabos

Sat 10/4

1:17 pm-11:13 pm

1 stop7h 56m

$371

Des MoinesCancún

DSM - CUN

DSMCUN

Des Moines

Wed 10/1

3:17 pm-8:11 am

1 stop16h 54m

Cancun

Wed 10/8

9:09 am-9:45 pm

1 stop12h 36m

$376

Des MoinesSan José del Cabo

DSM - SJD

DSMSJD

Des Moines

Mon 9/29

5:10 am-11:33 am

1 stop8h 23m

San José del Cabo Los Cabos

Mon 10/6

4:25 pm-9:00 am

1 stop14h 35m

$376

Des MoinesCancún

DSM - CUN

DSMCUN

Des Moines

Sun 9/7

5:11 am-3:03 pm

1 stop9h 52m

Cancun

Thu 9/11

2:50 pm-12:15 am

1 stop9h 25m

$376

Des MoinesCancún

DSM - CUN

DSMCUN

Des Moines

Fri 10/3

3:40 pm-9:15 am

2 stops17h 35m

Cancun

Wed 10/8

9:09 am-9:45 pm

1 stop12h 36m

$379

Des MoinesCancún

DSM - CUN

DSMCUN

Des Moines

Sat 10/11

9:19 am-8:04 am

1 stop22h 45m

Cancun

Thu 10/16

9:09 am-8:30 am

1 stop23h 21m

$380

Des MoinesSan José del Cabo

DSM - SJD

DSMSJD

Des Moines

Sun 10/19

7:03 am-7:28 pm

2 stops14h 25m

San José del Cabo Los Cabos

Sat 10/25

6:00 am-10:30 pm

2 stops14h 30m

$383

Des MoinesPuerto Vallarta

DSM - PVR

DSMPVR

Des Moines

Sat 9/27

8:16 am-12:25 pm

1 stop29h 09m

Puerto Vallarta Ordaz

Sat 10/4

11:01 am-11:13 pm

1 stop11h 12m

$392

Des MoinesCancún

DSM - CUN

DSMCUN

Des Moines

Fri 10/24

5:49 pm-12:44 pm

2 stops18h 55m

Cancun

Tue 10/28

1:49 pm-10:29 am

2 stops20h 40m

$394

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/15

Showing 1-10 of 55 results
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Best time to book a flight from Des Moines to Mexico

Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mexico

What is the cheapest month to book a flight from Des Moines to Mexico?

Currently, May is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $387). Flying from Des Moines to Mexico in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to MX?

Find hourly flight availability from Des Moines to Mexico. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 16, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Mexico as you normally would.

Reviews of airlines servicing Mexico

Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated August 16, 2025.
See what other customers who have flown with Southwest, Delta, and Aeromexico from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,246 reviews

Boarding

8.1

Entertainment

7.5

Overall

8.0

Comfort

8.0

Food

7.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,246 reviews
Southwest
8.0
Very good
4,246 reviews

Boarding

8.1

Entertainment

7.5

Overall

8.0

Comfort

8.0

Food

7.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
8.0
Very good
7,985 reviews
Southwest
8.0
Very good
4,246 reviews

Boarding

8.1

Entertainment

7.5

Overall

8.0

Comfort

8.0

Food

7.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Aeromexico
7.5
Good
1,722 reviews
Southwest
8.0
Very good
4,246 reviews

Boarding

8.1

Entertainment

7.5

Overall

8.0

Comfort

8.0

Food

7.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,916 reviews
Southwest
8.0
Very good
4,246 reviews

Boarding

8.1

Entertainment

7.5

Overall

8.0

Comfort

8.0

Food

7.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,246 reviews

Boarding

8.1

Entertainment

7.5

Overall

8.0

Comfort

8.0

Food

7.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mexico?

    Most people fly from Des Moines (DSM) if they book a flight from Des Moines to Mexico. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.

  • What are the cheapest airlines to fly from Des Moines to Mexico one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $151. Users have also found prices from $179 and $265 on Aeromexico and Frontier, respectively.

  • What are the most popular routes from Des Moines to Mexico?

    Most travelers choose Des Moines - Cancun, Des Moines - Cozumel or Des Moines - San José del Cabo Los Cabos when deciding on the best route from Des Moines to Mexico.

  • Can I find deals for flights from Des Moines to Mexico that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mexico flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mexico?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mexico.

  • Can I find deals for business class flights from Des Moines to Mexico?

    Yes. Cheapflights offers flight deals from Des Moines to Mexico by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mexico?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $387). Flying from Des Moines to Mexico in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 5 airlines flying from Des Moines to Mexico

Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$300Average$588FlexibilityNo cancel feeOn-timeN/A
AeromexicoCheapest$350Average$507FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$423Average$650FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$428Average$640FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$460Average$635FlexibilityNo cancel feeOn-time63%

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