$156+ Cheap flights from Des Moines (DSM) to Mexico
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/23. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
Mar 12 — Mar 191
1 adult, Economy
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Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 10, 2026.
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 10, 2026.
This Orbitz deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:27 pm
DSM
- CUN
1 stop20h 50m
Frontier
Wed 3/42:27 pm
CUN
- DSM
1 stop29h 15m
Frontier
Deal found 2/8![Frontier logo]()
$321
This Priceline deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:59 pm
DSM
- CUN
1 stop20h 18m
Frontier
Sat 3/711:08 am
CUN
- DSM
1 stop9h 08m
Frontier
Deal found 2/8![Frontier logo]()
$367
This Kiwi.com deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/98:21 pm
DSM
- CUN
1 stop14h 55m
Frontier
Mon 3/1610:08 am
CUN
- DSM
1 stop9h 08m
Frontier
Deal found 2/7![Frontier logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:27 pm
DSM
- CUN
1 stop20h 50m
Frontier
Fri 3/611:08 am
CUN
- DSM
1 stop9h 08m
Frontier
Deal found 2/8![Frontier logo]()
$378
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/98:21 pm
DSM
- CUN
1 stop14h 55m
Frontier
Sun 3/153:54 pm
CUN
- DSM
1 stop27h 22m
Frontier
Deal found 2/8![Frontier logo]()
$381
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/78:21 pm
DSM
- CUN
1 stop13h 55m
Frontier
Fri 3/1310:08 am
CUN
- DSM
1 stop9h 08m
Frontier
Deal found 2/8![Frontier logo]()
$385
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/98:21 pm
DSM
- CUN
1 stop14h 55m
Frontier
Tue 3/173:54 pm
CUN
- DSM
1 stop27h 22m
Frontier
Deal found 2/8![Frontier logo]()
$395
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- CUN
2 stops34h 40m
Frontier
Fri 3/1310:08 am
CUN
- DSM
1 stop9h 08m
Frontier
Deal found 2/10![Frontier logo]()
$415
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:21 pm
DSM
- MTY
1 stop22h 44m
Multiple Airlines
Fri 4/312:05 pm
MTY
- DSM
1 stop7h 50m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$417
This Frontier deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:00 am
DSM
- CUN
2 stops22h 09m
Frontier
Mon 3/1610:08 am
CUN
- DSM
1 stop9h 08m
Frontier
Deal found 2/7![Frontier logo]()
$421
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- MEX
2 stops33h 04m
Multiple Airlines
Tue 3/1011:55 am
MEX
- DSM
1 stop27h 07m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$434
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/247:00 am
DSM
- CZM
1 stop7h 11m
American Airlines
Tue 3/312:01 pm
CZM
- DSM
1 stop8h 55m
American Airlines
Deal found 2/7![American Airlines logo]()
$447
Best flights from Des Moines to MexicoDiscover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 10, 2026.
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:21 pm
DSM
- MTY
1 stop22h 44m
Multiple Airlines
Fri 4/312:05 pm
MTY
- DSM
1 stop7h 50m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$417
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/37:05 am
DSM
- CUN
1 stop6h 30m
American Airlines
Fri 5/81:00 pm
CUN
- DSM
1 stop10h 59m
American Airlines
Deal found 2/7![American Airlines logo]()
$466
This Aeromexico deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:50 am
DSM
- CUN
1 stop8h 35m
Aeromexico
Wed 3/412:25 pm
CUN
- DSM
1 stop9h 24m
Aeromexico
Deal found 2/8![Aeromexico logo]()
$466
This Delta deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:10 am
DSM
- CUN
1 stop6h 54m
Delta
Fri 5/89:55 am
CUN
- DSM
2 stops10h 41m
Delta
Deal found 2/7![Delta logo]()
$470
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:04 pm
DSM
- CZM
2 stops20h 19m
United Airlines
Tue 3/313:52 pm
CZM
- DSM
1 stop5h 51m
United Airlines
Deal found 2/8![United Airlines logo]()
$504
This Southwest deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:30 am
DSM
- SJD
1 stop10h 05m
Southwest
Tue 3/3110:10 am
SJD
- DSM
1 stop9h 55m
Southwest
Deal found 2/7![Southwest logo]()
$530
This Priceline deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2210:55 am
DSM
- MEX
1 stop9h 50m
Frontier
Sun 3/293:55 pm
MEX
- DSM
2 stops26h 21m
Frontier
Deal found 2/8![Frontier logo]()
$559
This Kissandfly.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:04 pm
DSM
- MID
2 stops25h 48m
Lufthansa
Thu 4/27:00 am
MID
- DSM
2 stops15h 42m
Lufthansa
Deal found 2/9![Lufthansa logo]()
$677
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:00 am
DSM
- CUN
2 stops52h 20m
Multiple Airlines
Sun 3/153:54 pm
CUN
- DSM
1 stop27h 22m
Multiple Airlines
Deal found 2/8![Multiple Airlines logo]()
$459
This Delta deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:33 pm
DSM
- CUN
1 stop5h 30m
Delta
Tue 6/28:15 am
CUN
- DSM
1 stop9h 38m
Delta
Deal found 2/7![Delta logo]()
$488
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:52 am
DSM
- SJD
1 stop7h 40m
United Airlines
Fri 3/612:49 pm
SJD
- DSM
1 stop8h 38m
United Airlines
Deal found 2/9![United Airlines logo]()
$510
This Aeromexico deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:35 am
DSM
- SJD
2 stops14h 08m
Aeromexico
Wed 4/112:35 pm
SJD
- DSM
1 stop8h 03m
Aeromexico
Deal found 2/9![Aeromexico logo]()
$525
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:21 pm
DSM
- MEX
2 stops26h 39m
Multiple Airlines
Fri 4/38:40 am
MEX
- DSM
1 stop9h 34m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$481
This Delta deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:24 am
DSM
- SJD
1 stop9h 45m
Delta
Fri 3/66:05 am
SJD
- DSM
2 stops15h 23m
Delta
Deal found 2/6![Delta logo]()
$490
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/147:27 pm
DSM
- BJX
1 stop26h 31m
American Airlines
Tue 3/248:25 am
BJX
- DSM
1 stop25h 09m
American Airlines
Deal found 2/10![American Airlines logo]()
$549
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:49 pm
DSM
- SJD
2 stops16h 16m
United Airlines
Tue 3/311:44 pm
SJD
- DSM
1 stop6h 59m
United Airlines
Deal found 2/8![United Airlines logo]()
$530
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:21 pm
DSM
- GDL
2 stops25h 49m
Multiple Airlines
Fri 4/310:25 am
GDL
- DSM
1 stop9h 30m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$485
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:24 am
DSM
- SJD
2 stops13h 13m
Delta
Fri 3/66:05 am
SJD
- DSM
2 stops15h 23m
Delta
Deal found 2/9![Delta logo]()
$490
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/285:05 am
DSM
- BJX
1 stop9h 30m
American Airlines
Sat 4/48:00 am
BJX
- DSM
1 stop5h 56m
American Airlines
Deal found 2/7![American Airlines logo]()
$558
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:45 pm
DSM
- PVR
2 stops17h 25m
United Airlines
Wed 5/612:19 pm
PVR
- DSM
2 stops21h 18m
United Airlines
Deal found 2/8![United Airlines logo]()
$531
This Aeromexico deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1811:51 am
DSM
- BJX
1 stop7h 08m
Aeromexico
Wed 4/225:50 am
BJX
- DSM
2 stops10h 55m
Aeromexico
Deal found 2/7![Aeromexico logo]()
$585
This Delta deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2511:33 am
DSM
- CUN
2 stops12h 59m
Delta
Wed 4/111:05 am
CUN
- DSM
2 stops11h 33m
Delta
Deal found 2/8![Delta logo]()
$492
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2111:43 am
DSM
- MTY
1 stop8h 32m
Multiple Airlines
Tue 3/246:55 pm
MTY
- DSM
2 stops41h 34m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$507
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/293:26 pm
DSM
- GDL
1 stop8h 24m
American Airlines
Fri 4/171:29 pm
GDL
- DSM
1 stop9h 30m
American Airlines
Deal found 2/9![American Airlines logo]()
$564
This Aeromexico deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:29 am
DSM
- BJX
1 stop13h 30m
Aeromexico
Mon 5/188:05 pm
BJX
- DSM
2 stops20h 48m
Aeromexico
Deal found 2/8![Aeromexico logo]()
$590
This Delta deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/275:24 am
DSM
- CUN
1 stop10h 21m
Delta
Wed 3/412:25 pm
CUN
- DSM
1 stop9h 24m
Delta
Deal found 2/8![Delta logo]()
$492
This Kissandfly.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/271:30 pm
DSM
- MLM
2 stops29h 52m
Lufthansa
Fri 4/36:50 am
MLM
- DSM
2 stops28h 57m
Lufthansa
Deal found 2/10![Lufthansa logo]()
$726
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:20 am
DSM
- MEX
1 stop5h 55m
United Airlines
Mon 4/209:35 am
MEX
- DSM
1 stop12h 08m
United Airlines
Deal found 2/8![United Airlines logo]()
$560
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/238:21 pm
DSM
- MEX
1 stop21h 44m
Multiple Airlines
Mon 4/68:40 am
MEX
- DSM
1 stop9h 34m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$512
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:27 pm
DSM
- MID
1 stop19h 40m
American Airlines
Fri 4/31:54 pm
MID
- DSM
1 stop9h 02m
American Airlines
Deal found 2/10![American Airlines logo]()
$573
Last-minute flights from Des Moines to MexicoDiscover last-minute flight deals from Des Moines to Mexico. Data last updated February 10, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico. Data last updated February 10, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/157:27 pm
DSM
- CUN
1 stop20h 50m
Frontier
Sat 2/211:18 pm
CUN
- DSM
2 stops30h 32m
Frontier
Deal found 2/8![Frontier logo]()
$451
This Delta deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:50 am
DSM
- CUN
1 stop8h 35m
Delta
Wed 2/253:00 pm
CUN
- DSM
1 stop7h 20m
Delta
Deal found 2/8![Delta logo]()
$468
This Delta deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:24 am
DSM
- SJD
1 stop9h 45m
Delta
Fri 3/66:05 am
SJD
- DSM
2 stops15h 23m
Delta
Deal found 2/6![Delta logo]()
$490
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:05 am
DSM
- SJD
2 stops11h 23m
American Airlines
Fri 3/61:01 pm
SJD
- DSM
2 stops9h 47m
American Airlines
Deal found 2/8![American Airlines logo]()
$495
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- MEX
2 stops33h 04m
Multiple Airlines
Tue 3/1011:55 am
MEX
- DSM
1 stop27h 07m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$434
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/188:21 pm
DSM
- MTY
1 stop22h 44m
Multiple Airlines
Tue 3/243:41 pm
MTY
- DSM
2 stops44h 48m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$481
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/247:00 am
DSM
- CZM
1 stop7h 11m
American Airlines
Tue 3/312:01 pm
CZM
- DSM
1 stop8h 55m
American Airlines
Deal found 2/7![American Airlines logo]()
$447
This SmartFares deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:35 am
DSM
- CZM
1 stop8h 10m
Aeromexico
Tue 3/312:00 pm
CZM
- DSM
1 stop7h 38m
Aeromexico
Deal found 2/8![Aeromexico logo]()
$480
This Aeromexico deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:35 am
DSM
- CZM
1 stop8h 10m
Aeromexico
Wed 4/12:00 pm
CZM
- DSM
1 stop7h 38m
Aeromexico
Deal found 2/8![Aeromexico logo]()
$491
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:21 pm
DSM
- MTY
1 stop22h 44m
Multiple Airlines
Fri 4/312:05 pm
MTY
- DSM
1 stop7h 50m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$417
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:21 pm
DSM
- MEX
2 stops26h 39m
Multiple Airlines
Fri 4/38:55 am
MEX
- DSM
1 stop9h 19m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$479
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:21 pm
DSM
- GDL
2 stops42h 17m
Multiple Airlines
Fri 4/310:25 am
GDL
- DSM
1 stop9h 30m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$484
One-way flights from Des Moines to MexicoSearch for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated February 10, 2026.
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated February 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/233:32 pm
DSM
- MEX
1 stop29h 33m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$160
This Priceline deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:20 pm
DSM
- CUN
1 stop24h 19m
Frontier
Deal found 2/9![Frontier logo]()
$196
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/235:24 am
DSM
- CUN
1 stop9h 11m
Delta
Deal found 2/9![Delta logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/168:21 pm
DSM
- CUN
3 stops45h 00m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/168:21 pm
DSM
- CUN
2 stops38h 21m
Frontier
Deal found 2/9![Frontier logo]()
$214
This Vakatrip deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Vakatrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:21 pm
DSM
- CUN
1 stop15h 00m
Frontier
Deal found 2/10![Frontier logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/83:32 pm
DSM
- CUN
2 stops47h 07m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$221
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:24 am
DSM
- SJD
2 stops13h 13m
Delta
Deal found 2/9![Delta logo]()
$223
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/44:48 pm
DSM
- CUN
1 stop17h 15m
American Airlines
Deal found 2/10![American Airlines logo]()
$230
This Aeromexico deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/235:24 am
DSM
- CZM
1 stop8h 31m
Aeromexico
Deal found 2/7![Aeromexico logo]()
$233
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1711:33 am
DSM
- CUN
1 stop8h 47m
Delta
Deal found 2/9![Delta logo]()
$239
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:52 am
DSM
- SJD
1 stop7h 40m
United Airlines
Deal found 2/9![United Airlines logo]()
$243
Find flight deals from Des Moines to Mexico
Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated February 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $321 (Orbitz) |
One-way from | $160 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $592 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 10, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.
Fly from
Des Moines
Fly to
Mexico
Route
Depart
Return
Price
Des MoinesMonterrey
DSM - MTY
DSMMTY
Des Moines
Fri 3/27
8:21 pm-6:05 pm
1 stop22h 44m
Monterrey Gen Mariano Escobedo
Fri 4/3
12:05 pm-8:55 pm
1 stop7h 50m
$417
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Sun 3/8
7:00 am-11:20 am
2 stops52h 20m
Cancun
Sun 3/15
3:54 pm-7:16 pm
1 stop27h 22m
$459
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Sun 5/3
7:05 am-1:35 pm
1 stop6h 30m
Cancun
Fri 5/8
1:00 pm-11:59 pm
1 stop10h 59m
$466
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Mon 3/2
6:50 am-4:25 pm
1 stop8h 35m
Cancun
Wed 3/4
12:25 pm-8:49 pm
1 stop9h 24m
$466
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Mon 5/4
6:10 am-1:04 pm
1 stop6h 54m
Cancun
Fri 5/8
9:55 am-8:36 pm
2 stops10h 41m
$470
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Fri 3/27
8:21 pm-10:00 pm
2 stops26h 39m
Mexico City Benito Juarez
Fri 4/3
8:40 am-7:14 pm
1 stop9h 34m
$481
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Fri 3/27
8:21 pm-9:10 pm
2 stops25h 49m
Guadalajara Miguel Hidal
Fri 4/3
10:25 am-8:55 pm
1 stop9h 30m
$485
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 5/27
2:33 pm-8:03 pm
1 stop5h 30m
Cancun
Tue 6/2
8:15 am-5:53 pm
1 stop9h 38m
$488
Des MoinesSan José del Cabo
DSM - SJD
DSMSJD
Des Moines
Tue 3/3
5:24 am-2:09 pm
1 stop9h 45m
San José del Cabo Los Cabos
Fri 3/6
6:05 am-10:28 pm
2 stops15h 23m
$490
Des MoinesSan José del Cabo
DSM - SJD
DSMSJD
Des Moines
Wed 3/4
5:24 am-5:37 pm
2 stops13h 13m
San José del Cabo Los Cabos
Fri 3/6
6:05 am-10:28 pm
2 stops15h 23m
$490
Showing 1-10 of 60 results
Best time to book a flight from Des Moines to Mexico
Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
DSM-MTY
DSM-MEX
DSM-CZM
DSM-CUN
DSM-GDL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico
DSM-MX0
DSM-MTY
DSM-MEX
DSM-CZM
DSM-CUN
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, October is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $241). Flying from Des Moines to Mexico in July is currently the most expensive (average of $475). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Mexico
Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated February 10, 2026.
See what other customers who have flown with Southwest, Delta, and United Airlines from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mexico
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Complete your trip
Complete your trip to Mexico by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and Mexico flights
Browse other Des Moines and Mexico flight options. Last updated on February 10, 2026.
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Des Moines to Mexico flights
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Consider these flights traveling to Mexico regions.
Top 5 airlines flying from Des Moines to Mexico
Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$220 | Average$597 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$249 | Average$505 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$379 | Average$651 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$389 | Average$669 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$569 | Average$690 | FlexibilityNo cancel fee | On-time63% |