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$184+ Cheap flights from Des Moines (DSM) to Mexico

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/31. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
Nov 20 — Nov 271
Thu 11/20
Thu 11/27
1 adult, Economy
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Find flight deals from Des Moines to Mexico

Cheapest flights from Des Moines to Mexico
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 21, 2025.

This Mytrip deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:56 pmDSM - CUN
2 stops20h 28mMultiple Airlines
Thu 12/112:36 pmCUN - DSM
1 stop8h 45mMultiple Airlines
Deal found 10/20$373
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:53 pmDSM - MEX
2 stops27h 07mMultiple Airlines
Mon 12/88:10 amMEX - DSM
1 stop10h 53mMultiple Airlines
Deal found 10/19$383
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/287:46 pmDSM - MEX
2 stops29h 59mMultiple Airlines
Mon 12/88:10 amMEX - DSM
1 stop10h 53mMultiple Airlines
Deal found 10/19$401
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:58 pmDSM - GDL
1 stop24h 42mMultiple Airlines
Fri 12/1210:25 amGDL - DSM
1 stop8h 13mMultiple Airlines
Deal found 10/20$417
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/209:19 amDSM - CUN
1 stop27h 16mMultiple Airlines
Tue 11/252:44 pmCUN - DSM
1 stop9h 40mMultiple Airlines
Deal found 10/18$420
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:56 pmDSM - MEX
2 stops28h 04mMultiple Airlines
Mon 12/88:10 amMEX - DSM
1 stop10h 53mMultiple Airlines
Deal found 10/19$434
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/57:28 pmDSM - MEX
1 stop24h 37mMultiple Airlines
Thu 12/1112:40 amMEX - DSM
2 stops18h 23mMultiple Airlines
Deal found 10/20$435
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/208:30 amDSM - GDL
1 stop12h 05mMultiple Airlines
Wed 12/39:35 amGDL - DSM
1 stop29h 56mMultiple Airlines
Deal found 10/20$440
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:00 amDSM - CZM
1 stop8h 53mAmerican Airlines
Tue 12/93:16 pmCZM - DSM
1 stop8h 13mAmerican Airlines
Deal found 10/19$454
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/44:21 pmDSM - MTY
1 stop22h 39mMultiple Airlines
Thu 12/118:00 pmMTY - DSM
2 stops23h 03mMultiple Airlines
Deal found 10/20$476
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/512:15 pmDSM - CZM
1 stop26h 31mAmerican Airlines
Fri 12/123:16 pmCZM - DSM
1 stop8h 13mAmerican Airlines
Deal found 10/20$483
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:56 pmDSM - GDL
2 stops22h 25mMultiple Airlines
Thu 12/1112:29 pmGDL - DSM
1 stop30h 09mMultiple Airlines
Deal found 10/20$498

Cheap flight deals from Des Moines to Mexico

Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated October 21, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$373
(Mytrip)

One-way from

$184
(American Airlines)

Popular in

December

Cheapest in

August

Average price

$692
Provider with most accurate pricing for Des Moines-Mexico City Benito Juarez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Mexico City Benito Juarez flights.
Search Deals
From Des Moines to Mexico
Search Deals
One-way flight from Des Moines to Mexico
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($117 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 21, 2025.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.

Fly from

Des Moines

Fly to

Mexico

Route

Depart

Return

Price

Des MoinesMexico City

DSM - MEX

DSMMEX

Des Moines

Mon 12/1

6:53 pm-10:00 pm

2 stops27h 07m

Mexico City Benito Juarez

Mon 12/8

8:10 am-7:03 pm

1 stop10h 53m

$419

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Thu 11/20

8:30 am-5:41 pm

1 stop9h 11m

Guadalajara Miguel Hidal

Wed 12/3

8:00 am-9:36 pm

2 stops37h 36m

$441

Des MoinesMexico City

DSM - MEX

DSMMEX

Des Moines

Fri 12/5

7:58 pm-5:05 pm

1 stop21h 07m

Mexico City Benito Juarez

Thu 12/11

12:40 am-7:03 pm

2 stops18h 23m

$444

Des MoinesCozumel

DSM - CZM

DSMCZM

Des Moines

Wed 1/7

6:48 pm-1:23 pm

2 stops18h 35m

Cozumel

Wed 1/14

2:25 pm-12:52 pm

2 stops22h 27m

$445

Des MoinesCozumel

DSM - CZM

DSMCZM

Des Moines

Fri 1/16

3:35 pm-12:58 pm

2 stops21h 23m

Cozumel

Fri 1/23

2:25 pm-11:44 pm

2 stops9h 19m

$445

Des MoinesCozumel

DSM - CZM

DSMCZM

Des Moines

Fri 1/9

6:48 pm-2:19 pm

1 stop19h 31m

Cozumel

Fri 1/16

2:25 pm-10:30 pm

1 stop8h 05m

$447

Des MoinesCozumel

DSM - CZM

DSMCZM

Des Moines

Tue 1/6

3:35 pm-1:23 pm

2 stops21h 48m

Cozumel

Tue 1/13

2:25 pm-10:30 pm

1 stop8h 05m

$470

Des MoinesMonterrey

DSM - MTY

DSMMTY

Des Moines

Thu 12/4

4:21 pm-3:00 pm

1 stop22h 39m

Monterrey Gen Mariano Escobedo

Thu 12/11

8:00 pm-7:03 pm

2 stops23h 03m

$476

Des MoinesMexico City

DSM - MEX

DSMMEX

Des Moines

Thu 12/4

2:56 pm-10:00 pm

2 stops31h 04m

Mexico City Benito Juarez

Thu 12/11

11:00 am-6:38 pm

1 stop31h 38m

$478

Des MoinesCancún

DSM - CUN

DSMCUN

Des Moines

Wed 12/3

2:16 pm-9:20 pm

1 stop6h 04m

Cancun

Wed 12/10

12:00 pm-5:47 pm

1 stop6h 47m

$486

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/19

Showing 1-10 of 60 results
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Best time to book a flight from Des Moines to Mexico

Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mexico

What is the cheapest month to book a flight from Des Moines to Mexico?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $244). Flying from Des Moines to Mexico in June is currently the most expensive (average of $472). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to MX?

Find hourly flight availability from Des Moines to Mexico. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 21, 2025.

A simple way to save on the total cost of your ticket is to fly from Des Moines to Mexico in the evening. If you’re flexible enough to do this you can expect to save up to 48% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Des Moines to Mexico?

Use this chart to determine the cheapest time to fly round-trip from Des Moines to Mexico. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Des Moines to Mexico flight should consider departing on Sunday afternoons when fares are most often at their lowest. Thursday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Mexico

Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated October 21, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,235 reviews

Boarding

8.1

Crew

8.6

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,235 reviews
Southwest
8.0
Very good
4,235 reviews

Boarding

8.1

Crew

8.6

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
7,979 reviews
Southwest
8.0
Very good
4,235 reviews

Boarding

8.1

Crew

8.6

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,988 reviews
Southwest
8.0
Very good
4,235 reviews

Boarding

8.1

Crew

8.6

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Aeromexico
7.4
Good
1,681 reviews
Southwest
8.0
Very good
4,235 reviews

Boarding

8.1

Crew

8.6

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,027 reviews
Southwest
8.0
Very good
4,235 reviews

Boarding

8.1

Crew

8.6

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mexico?

    Most people fly from Des Moines (DSM) if they book a flight from Des Moines to Mexico. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.

  • How long is the flight from Des Moines to Mexico?

    United Airlines, Delta, and American Airlines can get you from Des Moines to Mexico in just under 5h 38m. Your travel time can differ by up to 12h 57m. Airlines will cover a distance of 1149 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Des Moines to Mexico one-way?

    For one-way options, check prices for Delta. According to our data, you can fly for as low as $229. Users have also found prices from $229 and $233 on Aeromexico and American Airlines, respectively.

  • What are the most popular routes from Des Moines to Mexico?

    Most travelers choose Des Moines - Cancun, Des Moines - Cozumel or Des Moines - San José del Cabo Los Cabos when deciding on the best route from Des Moines to Mexico.

  • Can I find deals for flights from Des Moines to Mexico that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mexico flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mexico?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mexico.

  • Can I find deals for business class flights from Des Moines to Mexico?

    Yes. Cheapflights offers flight deals from Des Moines to Mexico by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mexico?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $244). Flying from Des Moines to Mexico in June is currently the most expensive (average of $472). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Mexico

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Des Moines to Mexico

Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$250Average$606FlexibilityNo cancel feeOn-timeN/A
AeromexicoCheapest$410Average$513FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$420Average$643FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$423Average$641FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$547Average$660FlexibilityNo cancel feeOn-time63%

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