$158+ Cheap flights from Des Moines (DSM) to Mexico
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/3. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
Jun 19 — Jun 261
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 20, 2026.
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Fri 7/1010:25 am
GDL
- DSM
1 stop9h 58m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$429
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:56 pm
DSM
- GDL
1 stop22h 58m
Multiple Airlines
Fri 7/310:25 am
GDL
- DSM
1 stop9h 46m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$435
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:56 pm
DSM
- GDL
1 stop22h 58m
Multiple Airlines
Tue 6/308:30 am
GDL
- DSM
2 stops28h 01m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$437
This Kiwi.com deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- CUN
1 stop22h 32m
Multiple Airlines
Wed 7/83:35 pm
CUN
- DSM
2 stops24h 32m
Multiple Airlines
Deal found 5/17![Multiple Airlines logo]()
$440
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Sun 6/288:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$444
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1310:01 pm
DSM
- CUN
2 stops36h 02m
Multiple Airlines
Tue 7/213:35 pm
CUN
- DSM
1 stop21h 59m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$445
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Fri 7/1011:00 am
MEX
- DSM
1 stop9h 23m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$451
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:19 pm
DSM
- CUN
1 stop22h 30m
Multiple Airlines
Thu 8/1310:25 am
CUN
- DSM
1 stop11h 06m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$453
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/310:01 pm
DSM
- MEX
1 stop23h 04m
Multiple Airlines
Wed 8/198:40 am
MEX
- DSM
2 stops27h 25m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$456
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/31:37 pm
DSM
- CUN
1 stop24h 47m
Multiple Airlines
Thu 8/1310:25 am
CUN
- DSM
1 stop11h 06m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$456
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Wed 7/810:45 pm
MEX
- DSM
2 stops37h 49m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$461
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:56 pm
DSM
- GDL
1 stop22h 58m
Multiple Airlines
Thu 7/28:30 am
GDL
- DSM
2 stops28h 01m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$466
Best flights from Des Moines to MexicoDiscover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 20, 2026.
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:01 pm
DSM
- MTY
1 stop22h 19m
Multiple Airlines
Fri 7/1012:05 pm
MTY
- DSM
1 stop8h 18m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$476
This Southwest deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:35 am
DSM
- CUN
1 stop7h 05m
Southwest
Thu 10/151:05 pm
CUN
- DSM
1 stop10h 25m
Southwest
Deal found 5/20![Southwest logo]()
$568
This American Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/24:48 pm
DSM
- MTY
1 stop5h 02m
American Airlines
Thu 7/94:42 pm
MTY
- DSM
1 stop6h 16m
American Airlines
Deal found 5/20![American Airlines logo]()
$574
This Delta deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/110:24 am
DSM
- CUN
2 stops10h 01m
Delta
Wed 7/88:00 am
CUN
- DSM
2 stops12h 49m
Delta
Deal found 5/16![Delta logo]()
$583
This United Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/25:17 pm
DSM
- CZM
2 stops22h 25m
United Airlines
Thu 7/93:52 pm
CZM
- DSM
1 stop5h 43m
United Airlines
Deal found 5/18![United Airlines logo]()
$600
This Aeromexico deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:35 am
DSM
- MTY
2 stops28h 10m
Aeromexico
Tue 7/75:15 pm
MTY
- DSM
2 stops28h 14m
Aeromexico
Deal found 5/15![Aeromexico logo]()
$619
This Kissandfly.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:50 pm
DSM
- PBC
2 stops17h 36m
Lufthansa
Fri 7/1012:25 pm
PBC
- DSM
2 stops28h 48m
Lufthansa
Deal found 5/19![Lufthansa logo]()
$869
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/288:36 pm
DSM
- GDL
1 stop21h 13m
Multiple Airlines
Tue 7/76:10 am
GDL
- DSM
2 stops30h 24m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$505
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/142:25 pm
DSM
- CUN
1 stop5h 50m
Delta
Sat 7/182:10 pm
CUN
- DSM
1 stop6h 58m
Delta
Deal found 5/19![Delta logo]()
$598
This Southwest deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/245:10 am
DSM
- CUN
2 stops8h 50m
Southwest
Tue 7/2812:40 pm
CUN
- DSM
2 stops10h 05m
Southwest
Deal found 5/20![Southwest logo]()
$598
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/158:00 am
DSM
- CUN
2 stops11h 19m
United Airlines
Sat 8/227:51 am
CUN
- DSM
1 stop6h 23m
United Airlines
Deal found 5/17![United Airlines logo]()
$618
This Aeromexico deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/173:00 pm
DSM
- MTY
2 stops20h 39m
Aeromexico
Thu 8/205:46 am
MTY
- DSM
2 stops11h 02m
Aeromexico
Deal found 5/15![Aeromexico logo]()
$653
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2510:15 am
DSM
- CUN
2 stops10h 00m
Delta
Tue 9/296:03 am
CUN
- DSM
2 stops11h 39m
Delta
Deal found 5/18![Delta logo]()
$598
This Southwest deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:10 am
DSM
- CUN
2 stops9h 55m
Southwest
Fri 7/1012:40 pm
CUN
- DSM
2 stops10h 50m
Southwest
Deal found 5/19![Southwest logo]()
$598
This American Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:12 am
DSM
- GDL
1 stop6h 36m
American Airlines
Sat 7/113:54 pm
GDL
- DSM
1 stop7h 04m
American Airlines
Deal found 5/19![American Airlines logo]()
$663
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:33 am
DSM
- CUN
2 stops12h 52m
Delta
Fri 7/108:00 am
CUN
- DSM
1 stop9h 52m
Delta
Deal found 5/19![Delta logo]()
$598
This Aeromexico deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/154:11 pm
DSM
- GDL
2 stops19h 33m
Aeromexico
Sat 8/2912:50 pm
GDL
- DSM
1 stop8h 47m
Aeromexico
Deal found 5/17![Aeromexico logo]()
$664
This United Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:50 pm
DSM
- SJD
2 stops16h 02m
United Airlines
Fri 7/101:17 pm
SJD
- DSM
1 stop8h 27m
United Airlines
Deal found 5/20![United Airlines logo]()
$668
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:32 pm
DSM
- PVR
1 stop16h 09m
American Airlines
Sat 10/103:55 pm
PVR
- DSM
1 stop6h 12m
American Airlines
Deal found 5/18![American Airlines logo]()
$673
This Kiwi.com deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:56 pm
DSM
- GDL
1 stop22h 58m
Multiple Airlines
Sun 6/2110:25 am
GDL
- DSM
1 stop8h 21m
Multiple Airlines
Deal found 5/17![Multiple Airlines logo]()
$691
This Delta deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:55 am
DSM
- CUN
2 stops13h 37m
Delta
Wed 8/198:05 am
CUN
- DSM
2 stops11h 10m
Delta
Deal found 5/19![Delta logo]()
$598
This United Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:15 am
DSM
- SJD
1 stop7h 48m
United Airlines
Sun 11/2212:49 pm
SJD
- DSM
1 stop8h 41m
United Airlines
Deal found 5/20![United Airlines logo]()
$668
This Southwest deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:10 am
DSM
- SJD
1 stop8h 10m
Southwest
Fri 7/1012:55 pm
SJD
- DSM
1 stop7h 25m
Southwest
Deal found 5/20![Southwest logo]()
$668
This Aeromexico deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:00 am
DSM
- PVR
2 stops16h 01m
Aeromexico
Sat 9/121:21 pm
PVR
- DSM
1 stop8h 05m
Aeromexico
Deal found 5/17![Aeromexico logo]()
$687
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/159:32 am
DSM
- GDL
1 stop13h 26m
American Airlines
Sat 8/293:54 pm
GDL
- DSM
1 stop26h 01m
American Airlines
Deal found 5/18![American Airlines logo]()
$707
This United Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:50 am
DSM
- PVR
1 stop8h 03m
United Airlines
Wed 6/2412:19 pm
PVR
- DSM
1 stop9h 21m
United Airlines
Deal found 5/19![United Airlines logo]()
$668
This Delta deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:35 am
DSM
- MEX
2 stops10h 45m
Delta
Tue 7/76:45 am
MEX
- DSM
2 stops13h 04m
Delta
Deal found 5/16![Delta logo]()
$630
This Aeromexico deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:35 am
DSM
- BJX
2 stops27h 55m
Aeromexico
Fri 7/108:21 pm
BJX
- DSM
2 stops18h 36m
Aeromexico
Deal found 5/19![Aeromexico logo]()
$710
This United Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:20 am
DSM
- PVR
1 stop8h 36m
United Airlines
Thu 6/252:52 pm
PVR
- DSM
1 stop6h 43m
United Airlines
Deal found 5/19![United Airlines logo]()
$668
This Delta deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/210:24 am
DSM
- MEX
2 stops13h 31m
Delta
Thu 7/98:50 am
MEX
- DSM
2 stops12h 39m
Delta
Deal found 5/17![Delta logo]()
$630
Last-minute flights from Des Moines to MexicoDiscover last-minute flight deals from Des Moines to Mexico. Data last updated May 20, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico. Data last updated May 20, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:17 pm
DSM
- GDL
2 stops35h 01m
Multiple Airlines
Thu 6/410:25 am
GDL
- DSM
1 stop8h 46m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$483
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:17 pm
DSM
- GDL
2 stops35h 01m
Multiple Airlines
Fri 6/510:25 am
GDL
- DSM
1 stop9h 41m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$488
This Kiwi.com deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Sun 6/288:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 5/20![Multiple Airlines logo]()
$444
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/1410:53 am
DSM
- GDL
2 stops8h 42m
Multiple Airlines
Fri 7/310:25 am
GDL
- DSM
1 stop9h 46m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$468
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/148:36 pm
DSM
- GDL
1 stop21h 13m
Multiple Airlines
Tue 6/308:30 am
GDL
- DSM
2 stops28h 01m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$473
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:56 pm
DSM
- GDL
1 stop22h 58m
Multiple Airlines
Fri 7/310:25 am
GDL
- DSM
1 stop9h 46m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$435
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:56 pm
DSM
- GDL
1 stop22h 58m
Multiple Airlines
Tue 6/308:30 am
GDL
- DSM
2 stops28h 01m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$437
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:56 pm
DSM
- GDL
1 stop22h 58m
Multiple Airlines
Thu 7/28:30 am
GDL
- DSM
2 stops28h 01m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$466
This Expedia deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/172:16 pm
DSM
- CUN
1 stop22h 32m
Frontier
Tue 6/303:35 pm
CUN
- DSM
1 stop21h 56m
Frontier
Deal found 5/16![Frontier logo]()
$474
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/172:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Fri 7/310:25 am
GDL
- DSM
1 stop9h 46m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$482
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/172:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Wed 6/2410:40 pm
MEX
- DSM
2 stops35h 42m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$487
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/199:56 pm
DSM
- GDL
1 stop22h 58m
Multiple Airlines
Fri 7/310:25 am
GDL
- DSM
1 stop9h 46m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$484
One-way flights from Des Moines to MexicoSearch for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated May 20, 2026.
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated May 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$158
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:38 pm
DSM
- MEX
1 stop24h 27m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/238:00 am
DSM
- MEX
2 stops14h 55m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/82:19 pm
DSM
- GDL
1 stop27h 06m
Multiple Airlines
Deal found 5/17![Multiple Airlines logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/192:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/610:01 pm
DSM
- GDL
1 stop22h 53m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/126:00 am
DSM
- MTY
1 stop18h 45m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$199
This Flightnetwork deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- CUN
1 stop22h 32m
Frontier
Deal found 5/17![Frontier logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1010:13 pm
DSM
- GDL
1 stop22h 41m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$206
This Trip.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:16 pm
DSM
- CUN
1 stop22h 32m
Frontier
Deal found 5/19![Frontier logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/210:57 am
DSM
- MEX
2 stops35h 33m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$211
Find flight deals from Des Moines to Mexico
Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated May 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $429 (Kiwi.com) |
One-way from | $158 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $644 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 20, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMonterrey
DSM - MTY
DSMMTY
Des Moines
Fri 7/3
10:01 pm-7:20 pm
1 stop22h 19m
Monterrey Gen Mariano Escobedo
Fri 7/10
12:05 pm-9:23 pm
1 stop8h 18m
$476
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Sun 6/28
8:36 pm-4:49 pm
1 stop21h 13m
Guadalajara Miguel Hidal
Tue 7/7
6:10 am-1:34 pm
2 stops30h 24m
$505
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 10/14
5:35 am-12:40 pm
1 stop7h 05m
Cancun
Thu 10/15
1:05 pm-11:30 pm
1 stop10h 25m
$568
Quickest round-trip
Des MoinesMonterrey
DSM - MTY
DSMMTY
Des Moines
Thu 7/2
4:48 pm-8:50 pm
1 stop5h 02m
Monterrey Gen Mariano Escobedo
Thu 7/9
4:42 pm-11:58 pm
1 stop6h 16m
$574
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 7/1
10:24 am-8:25 pm
2 stops10h 01m
Cancun
Wed 7/8
8:00 am-8:49 pm
2 stops12h 49m
$583
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Tue 7/14
2:25 pm-8:15 pm
1 stop5h 50m
Cancun
Sat 7/18
2:10 pm-9:08 pm
1 stop6h 58m
$598
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 7/24
5:10 am-2:00 pm
2 stops8h 50m
Cancun
Tue 7/28
12:40 pm-10:45 pm
2 stops10h 05m
$598
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 9/25
10:15 am-8:15 pm
2 stops10h 00m
Cancun
Tue 9/29
6:03 am-5:42 pm
2 stops11h 39m
$598
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 7/3
5:10 am-3:05 pm
2 stops9h 55m
Cancun
Fri 7/10
12:40 pm-11:30 pm
2 stops10h 50m
$598
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 7/3
7:33 am-8:25 pm
2 stops12h 52m
Cancun
Fri 7/10
8:00 am-5:52 pm
1 stop9h 52m
$598
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mexico
Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
DSM-GDL
DSM-CUN
DSM-SJD
DSM-PVR
DSM-MTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico
DSM-MX0
DSM-GDL
DSM-CUN
DSM-SJD
DSM-PVR
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, April is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $210). Flying from Des Moines to Mexico in May is currently the most expensive (average of $450). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How far ahead should I book a flight from Des Moines to Mexico?
Booking 18 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Mexico. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Reviews of airlines servicing Mexico
Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated May 20, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
7.9
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
7.9
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
7.9
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
7.9
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
7.9
Food
7.0
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mexico
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Complete your trip
Complete your trip to Mexico by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and Mexico flights
Browse other Des Moines and Mexico flight options. Last updated on May 20, 2026.
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Consider these flights traveling to Mexico regions.
Top 5 airlines flying from Des Moines to Mexico
Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$276 | Average$494 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$366 | Average$668 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$397 | Average$634 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$423 | Average$666 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$569 | Average$788 | FlexibilityNo cancel fee | On-time63% |