$181+ Cheap flights from Des Moines (DSM) to Mexico
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/19. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
Jun 4 — Jun 111
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:02 pm
DSM
- CUN
1 stop16h 18m
Multiple Airlines
Thu 6/1110:25 am
CUN
- DSM
1 stop11h 02m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CUN
1 stop16h 39m
Multiple Airlines
Thu 6/410:30 am
CUN
- DSM
1 stop10h 57m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$387
This Priceline deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/82:19 pm
DSM
- CUN
1 stop22h 30m
Frontier
Sun 7/123:35 pm
CUN
- DSM
1 stop21h 59m
Frontier
Deal found 5/3![Frontier logo]()
$393
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:02 pm
DSM
- CUN
1 stop16h 18m
Multiple Airlines
Tue 6/1611:11 am
CUN
- DSM
2 stops26h 20m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$408
This Expedia deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/272:19 pm
DSM
- CUN
1 stop22h 30m
Frontier
Sun 8/23:35 pm
CUN
- DSM
1 stop21h 59m
Frontier
Deal found 5/4![Frontier logo]()
$413
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/183:57 pm
DSM
- CUN
2 stops21h 54m
Multiple Airlines
Thu 6/2510:25 am
CUN
- DSM
1 stop11h 22m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$429
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/172:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Wed 6/249:45 pm
MEX
- DSM
2 stops23h 02m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$430
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:56 pm
DSM
- GDL
1 stop22h 56m
Multiple Airlines
Mon 6/227:35 pm
GDL
- DSM
2 stops40h 56m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$478
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Mon 6/810:45 pm
MEX
- DSM
2 stops37h 46m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$485
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:56 pm
DSM
- MEX
1 stop24h 49m
Multiple Airlines
Mon 6/2210:45 pm
MEX
- DSM
2 stops37h 46m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$489
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/222:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Tue 5/268:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$493
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/172:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Wed 6/249:30 am
GDL
- DSM
2 stops29h 28m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$503
Best flights from Des Moines to MexicoDiscover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:55 am
DSM
- CUN
2 stops12h 36m
Delta
Wed 8/198:05 am
CUN
- DSM
2 stops12h 53m
Delta
Deal found 5/4![Delta logo]()
$538
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/172:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Wed 6/2411:51 am
GDL
- DSM
1 stop30h 55m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$556
This Aeromexico deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/315:45 am
DSM
- SJD
1 stop7h 37m
Aeromexico
Fri 9/412:27 pm
SJD
- DSM
1 stop7h 59m
Aeromexico
Deal found 5/4![Aeromexico logo]()
$581
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:00 am
DSM
- CUN
1 stop7h 10m
United Airlines
Sat 6/2012:11 pm
CUN
- DSM
1 stop7h 14m
United Airlines
Deal found 5/1![United Airlines logo]()
$593
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:10 am
DSM
- CUN
2 stops9h 55m
Southwest
Thu 6/2512:40 pm
CUN
- DSM
2 stops10h 50m
Southwest
Deal found 5/4![Southwest logo]()
$598
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:48 pm
DSM
- MTY
1 stop5h 02m
American Airlines
Sat 7/46:00 am
MTY
- DSM
1 stop16h 41m
American Airlines
Deal found 5/4![American Airlines logo]()
$657
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/192:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Fri 6/2610:25 am
GDL
- DSM
1 stop9h 41m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$569
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:50 am
DSM
- CUN
2 stops13h 35m
Delta
Wed 7/88:00 am
CUN
- DSM
2 stops12h 49m
Delta
Deal found 4/30![Delta logo]()
$572
This Aeromexico deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:45 am
DSM
- PVR
1 stop7h 26m
Aeromexico
Thu 8/271:21 pm
PVR
- DSM
1 stop8h 05m
Aeromexico
Deal found 4/30![Aeromexico logo]()
$590
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1710:24 am
DSM
- CUN
2 stops10h 01m
Delta
Wed 6/248:00 am
CUN
- DSM
2 stops13h 08m
Delta
Deal found 5/3![Delta logo]()
$573
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:00 am
DSM
- PVR
3 stops28h 10m
United Airlines
Thu 8/2712:19 pm
PVR
- DSM
2 stops21h 31m
United Airlines
Deal found 5/4![United Airlines logo]()
$644
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:35 am
DSM
- CUN
2 stops7h 40m
Southwest
Mon 11/211:20 am
CUN
- DSM
2 stops12h 40m
Southwest
Deal found 5/1![Southwest logo]()
$663
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:32 pm
DSM
- PVR
1 stop16h 09m
American Airlines
Sat 10/1011:41 am
PVR
- DSM
1 stop6h 15m
American Airlines
Deal found 5/3![American Airlines logo]()
$668
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/315:45 am
DSM
- SJD
1 stop7h 37m
Delta
Fri 9/412:27 pm
SJD
- DSM
1 stop7h 59m
Delta
Deal found 5/3![Delta logo]()
$581
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:20 am
DSM
- BJX
1 stop5h 31m
United Airlines
Sat 7/45:00 am
BJX
- DSM
2 stops10h 15m
United Airlines
Deal found 5/4![United Airlines logo]()
$646
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/155:10 am
DSM
- CUN
2 stops8h 50m
Southwest
Mon 6/2212:40 pm
CUN
- DSM
2 stops10h 50m
Southwest
Deal found 5/1![Southwest logo]()
$663
This Aeromexico deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:05 am
DSM
- MEX
1 stop6h 35m
Aeromexico
Sat 8/159:55 pm
MEX
- DSM
2 stops18h 47m
Aeromexico
Deal found 4/30![Aeromexico logo]()
$664
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:01 pm
DSM
- PVR
2 stops20h 05m
American Airlines
Thu 6/43:01 pm
PVR
- DSM
1 stop7h 32m
American Airlines
Deal found 4/30![American Airlines logo]()
$672
This Lucky2Go deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Lucky2Go is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/169:00 am
DSM
- MTY
2 stops29h 51m
Multiple Airlines
Tue 6/236:00 am
MTY
- DSM
2 stops29h 55m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$715
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:00 am
DSM
- CUN
2 stops13h 19m
United Airlines
Sat 7/187:51 am
CUN
- DSM
2 stops11h 34m
United Airlines
Deal found 5/4![United Airlines logo]()
$658
This Aeromexico deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/157:00 am
DSM
- GDL
2 stops15h 23m
Aeromexico
Sat 8/296:55 am
GDL
- DSM
2 stops14h 31m
Aeromexico
Deal found 5/1![Aeromexico logo]()
$664
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/295:45 am
DSM
- SJD
1 stop7h 25m
Delta
Fri 10/212:15 pm
SJD
- DSM
1 stop8h 11m
Delta
Deal found 5/1![Delta logo]()
$616
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:13 pm
DSM
- MTY
1 stop17h 33m
American Airlines
Sat 8/14:53 pm
MTY
- DSM
1 stop6h 05m
American Airlines
Deal found 4/30![American Airlines logo]()
$690
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:00 am
DSM
- MTY
2 stops10h 02m
United Airlines
Tue 6/233:58 pm
MTY
- DSM
1 stop5h 42m
United Airlines
Deal found 5/2![United Airlines logo]()
$670
This Aeromexico deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/3111:04 am
DSM
- MTY
1 stop7h 16m
Aeromexico
Fri 9/412:15 pm
MTY
- DSM
1 stop7h 30m
Aeromexico
Deal found 5/3![Aeromexico logo]()
$674
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:04 am
DSM
- MEX
2 stops11h 51m
Delta
Tue 11/37:35 am
MEX
- DSM
2 stops11h 37m
Delta
Deal found 5/5![Delta logo]()
$626
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/197:12 pm
DSM
- MLM
1 stop16h 51m
American Airlines
Fri 6/2611:58 am
MLM
- DSM
1 stop27h 05m
American Airlines
Deal found 5/5![American Airlines logo]()
$709
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/308:30 pm
DSM
- CZM
2 stops19h 12m
United Airlines
Tue 9/13:52 pm
CZM
- DSM
2 stops19h 27m
United Airlines
Deal found 4/30![United Airlines logo]()
$684
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/411:22 am
DSM
- CUN
1 stop8h 53m
Delta
Sun 8/98:05 am
CUN
- DSM
1 stop9h 43m
Delta
Deal found 5/5![Delta logo]()
$627
This oojo deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/182:25 pm
DSM
- GDL
2 stops20h 03m
Aeromexico
Thu 6/258:52 am
GDL
- DSM
2 stops12h 39m
Aeromexico
Deal found 5/4![Aeromexico logo]()
$697
Last-minute flights from Des Moines to MexicoDiscover last-minute flight deals from Des Moines to Mexico. Data last updated May 5, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico. Data last updated May 5, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/222:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Tue 5/268:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$493
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CUN
1 stop16h 39m
Multiple Airlines
Thu 6/410:30 am
CUN
- DSM
1 stop10h 57m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$387
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Mon 6/810:45 pm
MEX
- DSM
2 stops37h 46m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$485
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:02 pm
DSM
- CUN
1 stop16h 18m
Multiple Airlines
Thu 6/1110:25 am
CUN
- DSM
1 stop11h 02m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:02 pm
DSM
- CUN
1 stop16h 18m
Multiple Airlines
Tue 6/1611:11 am
CUN
- DSM
2 stops26h 20m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$408
This Priceline deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:16 pm
DSM
- CUN
1 stop22h 32m
Frontier
Mon 6/153:01 pm
CUN
- DSM
2 stops46h 30m
Frontier
Deal found 5/2![Frontier logo]()
$458
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:56 pm
DSM
- GDL
1 stop22h 56m
Multiple Airlines
Mon 6/227:35 pm
GDL
- DSM
2 stops40h 56m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$478
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:56 pm
DSM
- MEX
1 stop24h 49m
Multiple Airlines
Mon 6/2210:45 pm
MEX
- DSM
2 stops37h 46m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$489
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/172:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Wed 6/249:45 pm
MEX
- DSM
2 stops23h 02m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$430
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/172:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Wed 6/249:30 am
GDL
- DSM
2 stops29h 28m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$503
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/183:57 pm
DSM
- CUN
2 stops21h 54m
Multiple Airlines
Thu 6/2510:25 am
CUN
- DSM
1 stop11h 22m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$429
This Priceline deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/242:16 pm
DSM
- MEX
1 stop28h 14m
Frontier
Mon 7/64:10 pm
MEX
- DSM
2 stops44h 24m
Frontier
Deal found 5/3![Frontier logo]()
$505
One-way flights from Des Moines to MexicoSearch for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/192:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$181
This Priceline deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/262:16 pm
DSM
- MEX
1 stop28h 14m
Frontier
Deal found 5/3![Frontier logo]()
$183
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- MEX
1 stop22h 59m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/82:19 pm
DSM
- GDL
1 stop27h 06m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/113:46 pm
DSM
- MEX
1 stop29h 19m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/202:19 pm
DSM
- CUN
1 stop22h 30m
Frontier
Deal found 4/30![Frontier logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:01 pm
DSM
- MEX
2 stops22h 59m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/264:57 pm
DSM
- CUN
1 stop16h 21m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/62:19 pm
DSM
- GDL
1 stop27h 06m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/122:16 pm
DSM
- MEX
2 stops41h 24m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$220
Find flight deals from Des Moines to Mexico
Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated May 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $316 (Kiwi.com) |
One-way from | $181 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $644 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 8/14
6:55 am-7:31 pm
2 stops12h 36m
Cancun
Wed 8/19
8:05 am-8:58 pm
2 stops12h 53m
$538
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Wed 6/17
2:16 pm-4:25 pm
1 stop27h 09m
Guadalajara Miguel Hidal
Wed 6/24
11:51 am-7:46 pm
1 stop30h 55m
$556
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Fri 6/19
2:16 pm-4:25 pm
1 stop27h 09m
Guadalajara Miguel Hidal
Fri 6/26
10:25 am-9:06 pm
1 stop9h 41m
$569
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 7/1
6:50 am-8:25 pm
2 stops13h 35m
Cancun
Wed 7/8
8:00 am-8:49 pm
2 stops12h 49m
$572
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 6/17
10:24 am-8:25 pm
2 stops10h 01m
Cancun
Wed 6/24
8:00 am-9:08 pm
2 stops13h 08m
$573
Des MoinesSan José del Cabo
DSM - SJD
DSMSJD
Des Moines
Mon 8/31
5:45 am-11:22 am
1 stop7h 37m
San José del Cabo Los Cabos
Fri 9/4
12:27 pm-10:26 pm
1 stop7h 59m
$581
Des MoinesSan José del Cabo
DSM - SJD
DSMSJD
Des Moines
Mon 8/31
5:45 am-11:22 am
1 stop7h 37m
San José del Cabo Los Cabos
Fri 9/4
12:27 pm-10:26 pm
1 stop7h 59m
$581
Des MoinesPuerto Vallarta
DSM - PVR
DSMPVR
Des Moines
Mon 8/24
5:45 am-12:11 pm
1 stop7h 26m
Puerto Vallarta Ordaz
Thu 8/27
1:21 pm-10:26 pm
1 stop8h 05m
$590
Quickest round-trip
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Mon 6/15
6:00 am-1:10 pm
1 stop7h 10m
Cancun
Sat 6/20
12:11 pm-7:25 pm
1 stop7h 14m
$593
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Thu 6/18
5:10 am-3:05 pm
2 stops9h 55m
Cancun
Thu 6/25
12:40 pm-11:30 pm
2 stops10h 50m
$598
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mexico
Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
DSM-CUN
DSM-GDL
DSM-SJD
DSM-MTY
DSM-PVR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico
DSM-MX0
DSM-CUN
DSM-GDL
DSM-SJD
DSM-MTY
How far ahead should I book a flight from Des Moines to Mexico?
Booking 19 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Mexico. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, May is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $192). Flying from Des Moines to Mexico in August is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Mexico
Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated May 5, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
7.9
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
7.9
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
7.9
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
7.9
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
7.9
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
7.9
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mexico
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Complete your trip
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Des Moines and Mexico flights
Browse other Des Moines and Mexico flight options. Last updated on May 5, 2026.
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Des Moines to Mexico flights
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Consider these flights traveling to Mexico regions.
Top 5 airlines flying from Des Moines to Mexico
Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$276 | Average$481 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$379 | Average$664 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$382 | Average$665 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$397 | Average$628 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$569 | Average$697 | FlexibilityNo cancel fee | On-time63% |