$134+ Cheap flights from Des Moines (DSM) to Mexico
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/9. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
Oct 22 — Oct 291
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:00 am -
1 stop14h 14m
Fri 11/205:19 pm -
1 stop7h 04m
Deal found 9/17![American Airlines logo]()
$438
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:12 pm -
1 stop22h 53m
Wed 11/41:21 pm -
1 stop11h 05m
Deal found 9/17![American Airlines logo]()
$447
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:00 am -
1 stop6h 24m
Wed 11/44:47 pm -
1 stop6h 43m
Deal found 9/17![United Airlines logo]()
$467
This Justfly.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:30 pm -
2 stops26h 25m
Mon 11/168:00 am -
1 stop11h 35m
Deal found 9/19![Frontier logo]()
$474
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/18:00 am -
2 stops32h 20m
Sun 11/811:28 pm -
1 stop14h 23m
Deal found 9/17![Multiple Airlines logo]()
$485
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/153:27 pm -
2 stops30h 43m
Fri 12/411:00 am -
1 stop9h 28m
Deal found 9/21![Multiple Airlines logo]()
$486
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:30 pm -
2 stops26h 45m
Wed 10/1411:55 am -
1 stop29h 47m
Deal found 9/17![Multiple Airlines logo]()
$488
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:30 pm -
1 stop20h 30m
Mon 11/168:00 am -
1 stop11h 35m
Deal found 9/19![Multiple Airlines logo]()
$493
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:25 am -
2 stops33h 50m
Fri 12/411:00 am -
1 stop9h 28m
Deal found 9/18![Multiple Airlines logo]()
$495
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:00 pm -
2 stops33h 40m
Tue 11/1011:00 am -
1 stop26h 55m
Deal found 9/19![Multiple Airlines logo]()
$505
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/39:45 am -
1 stop10h 29m
Tue 11/107:00 am -
1 stop11h 46m
Deal found 9/17![American Airlines logo]()
$516
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:00 am -
2 stops11h 45m
Wed 11/48:20 am -
2 stops13h 30m
Deal found 9/17![Southwest logo]()
$529
Best flights from Des Moines to MexicoDiscover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
This Justfly.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:30 pm -
2 stops26h 25m
Mon 11/168:00 am -
1 stop11h 35m
Deal found 9/19![Frontier logo]()
$474
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/42:45 pm -
1 stop27h 02m
Wed 11/182:52 pm -
1 stop31h 04m
Deal found 9/17![Multiple Airlines logo]()
$553
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:45 pm -
1 stop16h 38m
Thu 10/2912:16 pm -
1 stop10h 43m
Deal found 9/16![United Airlines logo]()
$558
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:00 am -
2 stops10h 00m
Sat 11/214:25 pm -
1 stop7h 35m
Deal found 9/21![Southwest logo]()
$600
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:15 am -
2 stops12h 40m
Thu 11/58:00 am -
2 stops12h 14m
Deal found 9/19![Delta logo]()
$600
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/287:16 pm -
1 stop16h 05m
Tue 12/84:51 pm -
1 stop16h 24m
Deal found 9/21![American Airlines logo]()
$645
This Aeromexico deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:55 am -
2 stops11h 32m
Tue 10/136:03 am -
2 stops15h 30m
Deal found 9/21![Aeromexico logo]()
$735
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:00 am -
1 stop13h 19m
Wed 10/212:49 pm -
1 stop7h 26m
Deal found 9/17![United Airlines logo]()
$558
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:24 am -
2 stops13h 44m
Mon 12/148:15 am -
2 stops12h 00m
Deal found 9/18![Delta logo]()
$625
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:40 am -
2 stops8h 35m
Fri 11/2012:35 pm -
2 stops8h 30m
Deal found 9/21![Southwest logo]()
$650
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/13:39 pm -
2 stops28h 46m
Sun 11/812:05 pm -
1 stop31h 09m
Deal found 9/17![Multiple Airlines logo]()
$651
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 am -
1 stop14h 14m
Sat 11/147:00 am -
1 stop11h 46m
Deal found 9/21![American Airlines logo]()
$661
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:45 pm -
2 stops17h 58m
Fri 11/203:48 pm -
1 stop6h 54m
Deal found 9/21![United Airlines logo]()
$617
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1811:00 am -
2 stops10h 45m
Mon 11/236:40 am -
2 stops14h 00m
Deal found 9/17![Delta logo]()
$641
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/55:20 am -
2 stops9h 35m
Thu 2/112:05 pm -
1 stop6h 40m
Deal found 9/19![Southwest logo]()
$660
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/265:00 am -
1 stop7h 42m
Fri 3/51:46 pm -
1 stop10h 11m
Deal found 9/21![American Airlines logo]()
$670
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:00 am -
1 stop6h 37m
Tue 11/108:39 am -
2 stops16h 03m
Deal found 9/17![United Airlines logo]()
$629
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/911:00 am -
2 stops11h 45m
Mon 11/167:15 pm -
2 stops24h 00m
Deal found 9/19![Delta logo]()
$641
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:40 am -
1 stop8h 05m
Mon 11/23:40 pm -
2 stops19h 45m
Deal found 9/17![Southwest logo]()
$687
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:27 pm -
2 stops9h 03m
Wed 12/23:30 pm -
1 stop6h 51m
Deal found 9/19![United Airlines logo]()
$637
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1011:01 am -
2 stops10h 39m
Wed 12/169:40 am -
2 stops11h 51m
Deal found 9/18![Delta logo]()
$641
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:14 am -
1 stop7h 00m
Tue 10/135:35 am -
1 stop8h 36m
Deal found 9/19![American Airlines logo]()
$732
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:45 pm -
2 stops18h 10m
Tue 12/83:31 pm -
1 stop6h 50m
Deal found 9/20![United Airlines logo]()
$644
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:28 am -
2 stops12h 27m
Tue 11/178:15 am -
2 stops12h 03m
Deal found 9/17![Delta logo]()
$645
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/411:23 am -
2 stops11h 12m
Wed 11/181:35 pm -
2 stops10h 07m
Deal found 9/17![United Airlines logo]()
$649
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/242:59 pm -
2 stops18h 51m
Fri 12/46:50 am -
2 stops15h 48m
Deal found 9/18![Delta logo]()
$661
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:00 am -
1 stop6h 02m
Tue 10/201:12 pm -
2 stops10h 23m
Deal found 9/19![United Airlines logo]()
$652
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:27 am -
2 stops11h 33m
Thu 11/57:05 am -
2 stops13h 35m
Deal found 9/17![Delta logo]()
$661
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/89:09 am -
1 stop6h 33m
Wed 1/2012:49 pm -
1 stop8h 41m
Deal found 9/18![United Airlines logo]()
$656
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:55 am -
2 stops12h 40m
Fri 10/166:15 am -
2 stops14h 18m
Deal found 9/22![Delta logo]()
$676
Last-minute flights from Des Moines to MexicoDiscover last-minute flight deals from Des Moines to Mexico. Data last updated September 22, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico. Data last updated September 22, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:30 pm -
2 stops26h 45m
Wed 10/1411:55 am -
1 stop29h 47m
Deal found 9/17![Multiple Airlines logo]()
$488
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:00 am -
1 stop8h 37m
Tue 10/203:38 pm -
1 stop7h 57m
Deal found 9/17![United Airlines logo]()
$560
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:42 pm -
1 stop14h 15m
Fri 10/3011:07 am -
1 stop11h 36m
Deal found 9/17![American Airlines logo]()
$529
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:45 pm -
1 stop16h 38m
Thu 10/2912:16 pm -
1 stop10h 43m
Deal found 9/16![United Airlines logo]()
$558
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:25 pm -
1 stop21h 25m
Wed 11/410:35 pm -
2 stops40h 01m
Deal found 9/20![Multiple Airlines logo]()
$579
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:00 am -
2 stops13h 55m
Thu 11/58:00 am -
2 stops12h 14m
Deal found 9/18![Delta logo]()
$575
This Aeromexico deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:35 am -
1 stop14h 20m
Wed 11/48:00 am -
1 stop8h 16m
Deal found 9/18![Aeromexico logo]()
$570
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:42 pm -
1 stop19h 13m
Thu 11/511:58 am -
1 stop7h 56m
Deal found 9/17![American Airlines logo]()
$540
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:00 pm -
2 stops33h 40m
Tue 11/1011:00 am -
1 stop26h 55m
Deal found 9/19![Multiple Airlines logo]()
$505
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:00 pm -
1 stop24h 10m
Thu 11/510:50 pm -
2 stops22h 45m
Deal found 9/17![Multiple Airlines logo]()
$571
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:12 pm -
1 stop22h 53m
Wed 11/41:21 pm -
1 stop11h 05m
Deal found 9/17![American Airlines logo]()
$447
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:55 am -
1 stop6h 03m
Wed 11/48:00 am -
2 stops12h 14m
Deal found 9/17![Delta logo]()
$580
One-way flights from Des Moines to MexicoSearch for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:00 am -
1 stop29h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$134
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:25 am -
1 stop29h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/810:01 pm -
2 stops37h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$172
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
2 stops37h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm -
1 stop25h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/138:30 pm -
2 stops43h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:15 pm -
2 stops24h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:25 am -
1 stop29h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/112:45 pm -
2 stops23h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/258:00 am -
3 stops58h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$210
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/157:00 pm -
2 stops15h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![United Airlines logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/1010:07 pm -
1 stop23h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Multiple Airlines logo]()
$212
Find flight deals from Des Moines to Mexico
Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated September 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $438 (American Airlines) |
One-way from | $134 (Kiwi.com) |
Popular in | December |
Cheapest in | March |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesGuadalajara
DSM Des Moines - GDL Guadalajara Miguel Hidal
DSMGDL
Des Moines
Mon 9/28
9:31 pm-9:56 am
2 stops37h 25m
Guadalajara Miguel Hidal
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$184
Des MoinesGuadalajara
DSM Des Moines - GDL Guadalajara Miguel Hidal
DSMGDL
Des Moines
Fri 11/13
7:30 am-12:57 pm
1 stop29h 27m
Guadalajara Miguel Hidal
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$190
Des MoinesMexico City
DSM Des Moines - MEX Mexico City Benito Juarez
DSMMEX
Des Moines
Mon 9/28
9:31 pm-8:35 am
2 stops36h 04m
Mexico City Benito Juarez
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$198
Des MoinesSan José del Cabo
DSM Des Moines - SJD San José del Cabo Los Cabos
DSMSJD
Des Moines
Fri 1/15
9:59 pm-2:46 pm
2 stops41h 47m
San José del Cabo Los Cabos
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$246
Des MoinesMérida
DSM Des Moines - MID Mérida Rejon
DSMMID
Des Moines
Mon 10/26
7:15 am-8:39 pm
3 stops38h 24m
Mérida Rejon
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$259
Des MoinesMexico City
DSM Des Moines - MEX Mexico City Benito Juarez
DSMMEX
Des Moines
Fri 12/4
9:18 pm-8:05 pm
1 stop22h 47m
Mexico City Benito Juarez
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$275
Des MoinesCancún
DSM Des Moines - CUN Cancun
DSMCUN
Des Moines
Sat 10/17
7:31 pm-12:00 pm
1 stop16h 29m
Cancun
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$276
Des MoinesCancún
DSM Des Moines - CUN Cancun
DSMCUN
Des Moines
Mon 12/14
6:18 pm-12:54 pm
2 stops17h 36m
Cancun
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$276
Des MoinesCancún
DSM Des Moines - CUN Cancun
DSMCUN
Des Moines
Tue 12/1
5:15 pm-11:25 am
2 stops17h 10m
Cancun
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$276
Quickest round-trip
Des MoinesCancún
DSM Des Moines - CUN Cancun
DSMCUN
Des Moines
Tue 12/15
8:07 am-4:10 pm
1 stop7h 03m
Cancun
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$276
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mexico
Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
DSM-CUN
DSM-MEX
DSM-GDL
DSM-SJD
DSM-MID
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico
DSM-MX0
DSM-CUN
DSM-MEX
DSM-GDL
DSM-SJD
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $590). Flying from Des Moines to Mexico in December is currently the most expensive (average of $778). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How far ahead should I book a flight from Des Moines to Mexico?
Booking 16 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Mexico. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Reviews of airlines servicing Mexico
Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated September 22, 2026.
See what other customers who have flown with Southwest,Delta, andAeromexico from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mexico
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Complete your trip
Complete your trip to Mexico by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Mexico, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Mexico flights
Browse other Des Moines and Mexico flight options. Last updated on September 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to Mexico flights
Consider these flights traveling from Des Moines to Mexico.
Fly to Mexico regions
Consider these flights traveling to Mexico regions.
Top 5 airlines flying from Des Moines to Mexico
Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$229 | Average$620 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$450 | Average$688 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$459 | Average$700 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$467 | Average$770 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$569 | Average$700 | FlexibilityNo cancel fee | On-time63% |