$140+ Cheap flights from Des Moines (DSM) to Mexico
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
Jul 4 — Jul 111
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 4, 2026.
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 4, 2026.
This Expedia deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- CUN
1 stop22h 32m
Frontier
Tue 7/73:31 pm
CUN
- DSM
1 stop22h 03m
Frontier
Deal found 6/1![Frontier logo]()
$358
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- CUN
2 stops33h 42m
Multiple Airlines
Tue 7/73:31 pm
CUN
- DSM
1 stop22h 03m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$430
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/152:19 pm
DSM
- MEX
1 stop28h 11m
Multiple Airlines
Wed 7/228:40 am
MEX
- DSM
2 stops30h 27m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$448
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Tue 7/711:55 am
MEX
- DSM
1 stop24h 04m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$449
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1310:01 pm
DSM
- MEX
1 stop24h 44m
Multiple Airlines
Mon 7/207:55 pm
MEX
- DSM
2 stops40h 04m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$452
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/242:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Tue 6/3011:00 am
MEX
- DSM
1 stop24h 59m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$454
This Orbitz deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:19 pm
DSM
- CUN
1 stop22h 30m
Frontier
Sun 8/163:31 pm
CUN
- DSM
1 stop22h 03m
Frontier
Deal found 6/1![Frontier logo]()
$454
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/269:56 pm
DSM
- MEX
1 stop24h 49m
Multiple Airlines
Tue 6/308:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$457
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Fri 7/1710:25 am
GDL
- DSM
1 stop9h 46m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$464
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/269:56 pm
DSM
- GDL
2 stops34h 19m
Multiple Airlines
Fri 7/310:25 am
GDL
- DSM
1 stop9h 46m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$465
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/202:19 pm
DSM
- MEX
1 stop28h 11m
Multiple Airlines
Tue 7/288:40 am
MEX
- DSM
1 stop27h 54m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$471
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/31:37 pm
DSM
- MTY
1 stop11h 08m
Multiple Airlines
Sun 7/511:00 am
MTY
- DSM
1 stop25h 34m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$471
Best flights from Des Moines to MexicoDiscover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 4, 2026.
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/79:21 pm
DSM
- GDL
1 stop23h 33m
Multiple Airlines
Sun 8/2310:25 am
GDL
- DSM
1 stop9h 35m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$501
This Expedia deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- CUN
1 stop22h 32m
Frontier
Sun 7/53:31 pm
CUN
- DSM
1 stop22h 03m
Frontier
Deal found 6/4![Frontier logo]()
$524
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:50 am
DSM
- CUN
1 stop6h 10m
Delta
Wed 7/89:11 am
CUN
- DSM
2 stops13h 18m
Delta
Deal found 6/1![Delta logo]()
$569
This United Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:00 am
DSM
- CUN
1 stop7h 10m
United Airlines
Fri 8/712:11 pm
CUN
- DSM
1 stop9h 11m
United Airlines
Deal found 5/31![United Airlines logo]()
$593
This Southwest deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:10 am
DSM
- CUN
1 stop6h 00m
Southwest
Sun 8/233:00 pm
CUN
- DSM
1 stop7h 50m
Southwest
Deal found 5/30![Southwest logo]()
$593
This Aeromexico deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:41 am
DSM
- CUN
1 stop14h 42m
Aeromexico
Wed 7/153:36 pm
CUN
- DSM
1 stop6h 53m
Aeromexico
Deal found 5/30![Aeromexico logo]()
$593
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/89:39 am
DSM
- MID
1 stop27h 45m
American Airlines
Sun 10/111:04 pm
MID
- DSM
1 stop9h 03m
American Airlines
Deal found 5/31![American Airlines logo]()
$649
This Delta deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:55 am
DSM
- CUN
2 stops12h 35m
Delta
Wed 8/196:04 am
CUN
- DSM
2 stops11h 46m
Delta
Deal found 6/4![Delta logo]()
$594
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/185:10 am
DSM
- CUN
1 stop8h 40m
Southwest
Wed 7/222:15 pm
CUN
- DSM
2 stops8h 35m
Southwest
Deal found 6/2![Southwest logo]()
$594
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/129:56 pm
DSM
- MTY
1 stop22h 24m
Multiple Airlines
Mon 6/228:35 pm
MTY
- DSM
2 stops39h 56m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$625
This United Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:00 am
DSM
- BJX
2 stops12h 31m
United Airlines
Tue 8/252:50 pm
BJX
- DSM
1 stop6h 40m
United Airlines
Deal found 6/3![United Airlines logo]()
$632
This Aeromexico deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/125:41 am
DSM
- SJD
1 stop7h 30m
Aeromexico
Thu 7/1612:16 pm
SJD
- DSM
1 stop8h 13m
Aeromexico
Deal found 5/30![Aeromexico logo]()
$643
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:30 am
DSM
- SJD
2 stops8h 48m
American Airlines
Wed 7/811:59 am
SJD
- DSM
2 stops9h 59m
American Airlines
Deal found 6/3![American Airlines logo]()
$653
This Southwest deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/205:10 am
DSM
- CUN
2 stops8h 50m
Southwest
Mon 7/2711:40 am
CUN
- DSM
2 stops11h 55m
Southwest
Deal found 5/30![Southwest logo]()
$598
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/172:19 pm
DSM
- MEX
1 stop28h 11m
Multiple Airlines
Mon 7/279:25 am
MEX
- DSM
2 stops10h 46m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$628
This United Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:50 pm
DSM
- CZM
2 stops19h 52m
United Airlines
Sat 8/153:52 pm
CZM
- DSM
1 stop6h 38m
United Airlines
Deal found 6/2![United Airlines logo]()
$634
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/167:05 am
DSM
- MEX
2 stops13h 00m
Delta
Thu 7/235:50 pm
MEX
- DSM
2 stops15h 55m
Delta
Deal found 6/1![Delta logo]()
$640
This Aeromexico deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/125:41 am
DSM
- PVR
1 stop7h 48m
Aeromexico
Thu 7/161:39 pm
PVR
- DSM
1 stop7h 50m
Aeromexico
Deal found 6/1![Aeromexico logo]()
$644
This American Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:22 pm
DSM
- GDL
1 stop17h 27m
American Airlines
Thu 8/2711:56 am
GDL
- DSM
1 stop10h 44m
American Airlines
Deal found 5/30![American Airlines logo]()
$654
This Southwest deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:20 am
DSM
- CUN
2 stops9h 45m
Southwest
Sun 7/511:15 am
CUN
- DSM
1 stop11h 20m
Southwest
Deal found 6/4![Southwest logo]()
$599
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:40 am
DSM
- PVR
1 stop7h 49m
Delta
Wed 8/191:39 pm
PVR
- DSM
1 stop7h 58m
Delta
Deal found 5/31![Delta logo]()
$643
This United Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:20 am
DSM
- MID
1 stop12h 45m
United Airlines
Thu 7/237:00 am
MID
- DSM
2 stops13h 22m
United Airlines
Deal found 5/31![United Airlines logo]()
$644
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/268:50 pm
DSM
- SJD
1 stop16h 14m
American Airlines
Sat 8/18:41 am
SJD
- DSM
2 stops13h 17m
American Airlines
Deal found 6/1![American Airlines logo]()
$673
This Aeromexico deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/154:11 pm
DSM
- GDL
2 stops19h 31m
Aeromexico
Sat 8/2912:50 pm
GDL
- DSM
1 stop8h 47m
Aeromexico
Deal found 5/31![Aeromexico logo]()
$674
This United Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:00 am
DSM
- PVR
1 stop8h 35m
United Airlines
Fri 10/301:00 pm
PVR
- DSM
1 stop10h 40m
United Airlines
Deal found 6/3![United Airlines logo]()
$644
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:00 am
DSM
- MEX
2 stops12h 30m
Delta
Thu 8/138:50 am
MEX
- DSM
2 stops12h 47m
Delta
Deal found 6/2![Delta logo]()
$653
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/284:48 pm
DSM
- BJX
1 stop6h 03m
American Airlines
Sun 7/125:32 pm
BJX
- DSM
1 stop14h 39m
American Airlines
Deal found 5/31![American Airlines logo]()
$676
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/25:10 am
DSM
- SJD
2 stops11h 15m
Southwest
Sun 7/512:00 pm
SJD
- DSM
1 stop8h 35m
Southwest
Deal found 6/1![Southwest logo]()
$698
This United Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am
DSM
- PVR
1 stop8h 06m
United Airlines
Wed 11/182:00 pm
PVR
- DSM
1 stop9h 01m
United Airlines
Deal found 6/3![United Airlines logo]()
$644
This Aeromexico deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/314:11 pm
DSM
- MTY
2 stops17h 39m
Aeromexico
Wed 9/27:45 am
MTY
- DSM
2 stops13h 52m
Aeromexico
Deal found 6/1![Aeromexico logo]()
$734
Last-minute flights from Des Moines to MexicoDiscover last-minute flight deals from Des Moines to Mexico. Data last updated June 4, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico. Data last updated June 4, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/242:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Tue 6/3011:00 am
MEX
- DSM
1 stop24h 59m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$454
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/269:56 pm
DSM
- MEX
1 stop24h 49m
Multiple Airlines
Tue 6/308:40 am
MEX
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$457
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/269:56 pm
DSM
- GDL
2 stops34h 19m
Multiple Airlines
Fri 7/310:25 am
GDL
- DSM
1 stop9h 46m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$465
This Expedia deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- CUN
1 stop22h 32m
Frontier
Tue 7/73:31 pm
CUN
- DSM
1 stop22h 03m
Frontier
Deal found 6/1![Frontier logo]()
$358
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- CUN
2 stops33h 42m
Multiple Airlines
Tue 7/73:31 pm
CUN
- DSM
1 stop22h 03m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$430
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Fri 7/1710:25 am
GDL
- DSM
1 stop9h 46m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$464
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Tue 7/711:55 am
MEX
- DSM
1 stop24h 04m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$449
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Fri 7/1710:25 am
GDL
- DSM
1 stop9h 46m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$479
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/59:33 pm
DSM
- GDL
1 stop20h 16m
Multiple Airlines
Thu 7/910:25 am
GDL
- DSM
1 stop9h 18m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$480
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1310:01 pm
DSM
- MEX
1 stop24h 44m
Multiple Airlines
Mon 7/207:55 pm
MEX
- DSM
2 stops40h 04m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$452
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/152:19 pm
DSM
- MEX
1 stop28h 11m
Multiple Airlines
Wed 7/228:40 am
MEX
- DSM
2 stops30h 27m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$448
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/202:19 pm
DSM
- MEX
1 stop28h 11m
Multiple Airlines
Tue 7/288:40 am
MEX
- DSM
1 stop27h 54m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$471
One-way flights from Des Moines to MexicoSearch for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated June 4, 2026.
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated June 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/262:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/238:00 am
DSM
- MEX
2 stops23h 40m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:38 pm
DSM
- MEX
1 stop24h 27m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$158
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/288:36 pm
DSM
- MTY
2 stops24h 47m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$192
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:56 pm
DSM
- GDL
2 stops34h 22m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/152:19 pm
DSM
- CUN
2 stops33h 39m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/172:19 pm
DSM
- MEX
1 stop28h 11m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$202
This Priceline deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/152:19 pm
DSM
- CUN
1 stop22h 30m
Frontier
Deal found 6/4![Frontier logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/59:33 pm
DSM
- GDL
1 stop27h 25m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/129:56 pm
DSM
- GDL
2 stops34h 19m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$216
Find flight deals from Des Moines to Mexico
Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated June 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $358 (Expedia) |
One-way from | $140 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $659 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 4, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Fri 8/7
9:21 pm-7:54 pm
1 stop23h 33m
Guadalajara Miguel Hidal
Sun 8/23
10:25 am-9:00 pm
1 stop9h 35m
$501
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 7/1
2:16 pm-12:48 pm
1 stop22h 32m
Cancun
Sun 7/5
3:31 pm-1:34 pm
1 stop22h 03m
$524
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 7/1
6:50 am-1:00 pm
1 stop6h 10m
Cancun
Wed 7/8
9:11 am-10:29 pm
2 stops13h 18m
$569
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Sat 8/1
6:00 am-1:10 pm
1 stop7h 10m
Cancun
Fri 8/7
12:11 pm-9:22 pm
1 stop9h 11m
$593
Quickest round-trip
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Tue 8/18
6:10 am-12:10 pm
1 stop6h 00m
Cancun
Sun 8/23
3:00 pm-10:50 pm
1 stop7h 50m
$593
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Thu 7/9
5:41 am-8:23 pm
1 stop14h 42m
Cancun
Wed 7/15
3:36 pm-10:29 pm
1 stop6h 53m
$593
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 8/14
6:55 am-7:30 pm
2 stops12h 35m
Cancun
Wed 8/19
6:04 am-5:50 pm
2 stops11h 46m
$594
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Sat 7/18
5:10 am-1:50 pm
1 stop8h 40m
Cancun
Wed 7/22
2:15 pm-10:50 pm
2 stops8h 35m
$594
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Mon 7/20
5:10 am-2:00 pm
2 stops8h 50m
Cancun
Mon 7/27
11:40 am-11:35 pm
2 stops11h 55m
$598
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 7/1
5:20 am-3:05 pm
2 stops9h 45m
Cancun
Sun 7/5
11:15 am-10:35 pm
1 stop11h 20m
$599
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mexico
Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
DSM-MEX
DSM-MTY
DSM-GDL
DSM-CUN
DSM-MID
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico
DSM-MX0
DSM-MEX
DSM-MTY
DSM-GDL
DSM-CUN
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, April is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $210). Flying from Des Moines to Mexico in May is currently the most expensive (average of $450). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How far ahead should I book a flight from Des Moines to Mexico?
Booking 19 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Mexico. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Reviews of airlines servicing Mexico
Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated June 4, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mexico
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Complete your trip
Complete your trip to Mexico by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and Mexico flights
Browse other Des Moines and Mexico flight options. Last updated on June 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to Mexico flights
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Fly to Mexico regions
Consider these flights traveling to Mexico regions.
Top 5 airlines flying from Des Moines to Mexico
Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$276 | Average$494 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$366 | Average$676 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$379 | Average$674 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$397 | Average$637 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$569 | Average$788 | FlexibilityNo cancel fee | On-time63% |