$228+ Cheap flights from Des Moines (DSM) to Mexico
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
Dec 4 — Dec 111
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/239:31 pm -
2 stops26h 44m
Thu 11/268:00 am -
1 stop11h 33m
Deal found 11/2![Multiple Airlines logo]()
$543
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/15:13 am -
1 stop15h 01m
Tue 12/81:20 pm -
1 stop12h 05m
Deal found 11/1![American Airlines logo]()
$552
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:41 pm -
1 stop23h 20m
Wed 12/910:18 am -
2 stops30h 28m
Deal found 10/31![Multiple Airlines logo]()
$583
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:32 pm -
1 stop16h 45m
Tue 12/153:34 pm -
1 stop8h 56m
Deal found 11/2![American Airlines logo]()
$587
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/287:16 pm -
1 stop16h 02m
Fri 12/412:11 pm -
1 stop7h 41m
Deal found 10/31![American Airlines logo]()
$592
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/297:24 pm -
1 stop16h 57m
Fri 12/41:29 pm -
1 stop11h 33m
Deal found 11/2![American Airlines logo]()
$605
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:31 pm -
1 stop15h 42m
Fri 12/114:40 pm -
1 stop7h 25m
Deal found 11/3![American Airlines logo]()
$607
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:54 am -
1 stop8h 42m
Tue 12/222:32 pm -
1 stop10h 26m
Deal found 10/31![American Airlines logo]()
$610
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:30 am -
1 stop7h 17m
Wed 12/26:09 am -
2 stops12h 59m
Deal found 11/3![Delta logo]()
$625
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/287:16 pm -
1 stop18h 07m
Sat 12/55:24 pm -
1 stop16h 51m
Deal found 10/31![American Airlines logo]()
$626
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:00 am -
1 stop8h 05m
Tue 12/84:09 pm -
1 stop9h 16m
Deal found 11/1![American Airlines logo]()
$630
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:38 am -
1 stop8h 30m
Fri 12/1111:21 am -
2 stops12h 17m
Deal found 10/30![Delta logo]()
$635
Best flights from Des Moines to MexicoDiscover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/171:30 pm -
1 stop7h 00m
Thu 1/215:55 am -
2 stops11h 40m
Deal found 11/1![Delta logo]()
$605
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/28:00 am -
2 stops10h 45m
Sat 2/611:00 am -
1 stop10h 15m
Deal found 11/3![Southwest logo]()
$635
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/235:29 pm -
2 stops20h 53m
Tue 3/22:12 pm -
2 stops19h 04m
Deal found 11/2![American Airlines logo]()
$656
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/315:12 pm -
2 stops21h 30m
Wed 1/64:50 pm -
1 stop6h 40m
Deal found 10/30![United Airlines logo]()
$666
This Aeromexico deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/245:45 am -
2 stops12h 42m
Wed 4/288:02 am -
2 stops13h 27m
Deal found 10/30![Aeromexico logo]()
$675
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/172:21 pm -
1 stop27h 26m
Sun 12/277:49 pm -
2 stops41h 00m
Deal found 11/3![Multiple Airlines logo]()
$915
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/315:30 am -
2 stops11h 09m
Fri 2/1211:00 am -
2 stops11h 13m
Deal found 11/2![Delta logo]()
$610
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/198:00 am -
2 stops10h 45m
Sat 1/308:30 am -
2 stops12h 45m
Deal found 11/1![Southwest logo]()
$635
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/103:00 pm -
1 stop23h 42m
Sat 4/172:05 pm -
1 stop9h 34m
Deal found 11/2![United Airlines logo]()
$670
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/315:30 am -
2 stops11h 09m
Wed 2/104:30 pm -
1 stop7h 08m
Deal found 10/31![Delta logo]()
$610
This Aeromexico deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/301:29 pm -
2 stops20h 17m
Wed 2/36:41 am -
2 stops15h 57m
Deal found 11/1![Aeromexico logo]()
$696
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/287:16 pm -
1 stop16h 05m
Tue 12/82:21 pm -
2 stops18h 54m
Deal found 11/4![American Airlines logo]()
$705
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/205:30 am -
1 stop7h 18m
Tue 1/2611:50 am -
2 stops11h 48m
Deal found 11/1![Delta logo]()
$610
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/168:00 am -
1 stop6h 25m
Tue 3/92:20 pm -
1 stop8h 13m
Deal found 11/3![United Airlines logo]()
$672
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/136:40 am -
1 stop8h 10m
Sun 12/2012:35 pm -
2 stops10h 00m
Deal found 10/30![Southwest logo]()
$692
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/146:05 am -
1 stop7h 31m
Mon 12/2112:35 pm -
1 stop6h 23m
Deal found 10/30![American Airlines logo]()
$710
This Aeromexico deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1711:04 am -
2 stops13h 26m
Wed 4/2112:55 pm -
1 stop8h 34m
Deal found 11/3![Aeromexico logo]()
$717
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/163:05 pm -
2 stops9h 05m
Mon 3/82:20 pm -
1 stop8h 13m
Deal found 11/3![United Airlines logo]()
$672
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/245:30 am -
1 stop10h 05m
Fri 1/2912:23 pm -
1 stop11h 15m
Deal found 11/3![Delta logo]()
$625
This Southwest deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:40 am -
2 stops9h 10m
Fri 12/251:05 pm -
1 stop6h 45m
Deal found 11/3![Southwest logo]()
$696
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/137:42 pm -
2 stops18h 40m
Sat 2/272:15 pm -
2 stops19h 01m
Deal found 11/1![American Airlines logo]()
$717
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/163:05 pm -
2 stops9h 05m
Wed 3/102:20 pm -
1 stop8h 13m
Deal found 11/3![United Airlines logo]()
$672
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/255:55 pm -
1 stop17h 55m
Wed 1/275:30 pm -
1 stop17h 42m
Deal found 11/3![Delta logo]()
$625
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:23 am -
2 stops33h 03m
Wed 12/21:30 pm -
1 stop9h 00m
Deal found 11/2![American Airlines logo]()
$740
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/219:35 pm -
1 stop21h 45m
Thu 12/319:40 am -
1 stop12h 42m
Deal found 10/31![Multiple Airlines logo]()
$986
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/16:30 pm -
2 stops18h 13m
Sat 2/612:55 pm -
1 stop7h 33m
Deal found 11/3![United Airlines logo]()
$687
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/164:56 pm -
2 stops19h 52m
Thu 1/281:50 pm -
1 stop7h 58m
Deal found 11/3![Delta logo]()
$630
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/256:30 pm -
2 stops18h 27m
Mon 2/13:31 pm -
1 stop6h 59m
Deal found 11/3![United Airlines logo]()
$687
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/96:14 pm -
1 stop20h 34m
Sat 1/166:00 am -
1 stop11h 29m
Deal found 10/31![American Airlines logo]()
$758
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/16:45 am -
2 stops13h 45m
Sun 2/78:00 am -
2 stops13h 48m
Deal found 10/30![Delta logo]()
$640
Last-minute flights from Des Moines to MexicoDiscover last-minute flight deals from Des Moines to Mexico. Data last updated November 4, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico. Data last updated November 4, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/239:31 pm -
2 stops26h 44m
Thu 11/268:00 am -
1 stop11h 33m
Deal found 11/2![Multiple Airlines logo]()
$543
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:30 am -
1 stop7h 17m
Wed 12/26:09 am -
2 stops12h 59m
Deal found 11/3![Delta logo]()
$625
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:41 pm -
1 stop23h 20m
Wed 12/910:18 am -
2 stops30h 28m
Deal found 10/31![Multiple Airlines logo]()
$583
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/287:16 pm -
1 stop16h 02m
Fri 12/412:11 pm -
1 stop7h 41m
Deal found 10/31![American Airlines logo]()
$592
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/287:16 pm -
1 stop18h 07m
Sat 12/55:24 pm -
1 stop16h 51m
Deal found 10/31![American Airlines logo]()
$626
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/297:24 pm -
1 stop16h 57m
Fri 12/41:29 pm -
1 stop11h 33m
Deal found 11/2![American Airlines logo]()
$605
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/15:13 am -
1 stop15h 01m
Tue 12/81:20 pm -
1 stop12h 05m
Deal found 11/1![American Airlines logo]()
$552
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:00 am -
1 stop8h 05m
Tue 12/84:09 pm -
1 stop9h 16m
Deal found 11/1![American Airlines logo]()
$630
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:38 am -
1 stop8h 30m
Fri 12/1111:21 am -
2 stops12h 17m
Deal found 10/30![Delta logo]()
$635
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:31 pm -
1 stop15h 42m
Fri 12/114:40 pm -
1 stop7h 25m
Deal found 11/3![American Airlines logo]()
$607
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:32 pm -
1 stop16h 45m
Tue 12/153:34 pm -
1 stop8h 56m
Deal found 11/2![American Airlines logo]()
$587
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:54 am -
1 stop8h 42m
Tue 12/222:32 pm -
1 stop10h 26m
Deal found 10/31![American Airlines logo]()
$610
One-way flights from Des Moines to MexicoSearch for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/148:30 am -
2 stops11h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/710:40 am -
3 stops36h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Multiple Airlines logo]()
$232
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:00 am -
2 stops34h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Multiple Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/72:50 pm -
2 stops46h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:35 pm -
2 stops24h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1311:40 am -
1 stop13h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/17:30 am -
3 stops56h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Multiple Airlines logo]()
$288
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/1310:41 am -
2 stops9h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Delta logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:04 pm -
1 stop24h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Multiple Airlines logo]()
$293
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:15 am -
1 stop6h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![United Airlines logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/209:31 pm -
2 stops25h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$297
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/18:00 am -
1 stop7h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![United Airlines logo]()
$299
Find flight deals from Des Moines to Mexico
Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated November 4, 2026.
Round-trip from | $390 (Kiwi.com) |
|---|---|
One-way from | $228 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesGuadalajara
DSM Des Moines - GDL Guadalajara Miguel Hidal
DSMGDL
Des Moines
Fri 12/11
9:18 pm-1:15 am
2 stops27h 57m
Guadalajara Miguel Hidal
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$276
Des MoinesCancún
DSM Des Moines - CUN Cancun
DSMCUN
Des Moines
Wed 1/20
10:40 am-9:30 pm
2 stops9h 50m
Cancun
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$292
Des MoinesCancún
DSM Des Moines - CUN Cancun
DSMCUN
Des Moines
Wed 1/13
10:41 am-9:30 pm
2 stops9h 49m
Cancun
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$292
Quickest round-trip
Des MoinesCancún
DSM Des Moines - CUN Cancun
DSMCUN
Des Moines
Tue 12/15
6:15 am-1:43 pm
1 stop6h 28m
Cancun
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$296
Des MoinesSan José del Cabo
DSM Des Moines - SJD San José del Cabo Los Cabos
DSMSJD
Des Moines
Mon 2/1
6:55 am-1:55 pm
2 stops8h 00m
San José del Cabo Los Cabos
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$299
Des MoinesSan José del Cabo
DSM Des Moines - SJD San José del Cabo Los Cabos
DSMSJD
Des Moines
Mon 2/1
8:00 am-2:32 pm
1 stop7h 32m
San José del Cabo Los Cabos
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$299
Des MoinesMazatlán
DSM Des Moines - MZT Mazatlán Gen Rafael Buelna
DSMMZT
Des Moines
Sun 11/15
6:00 am-12:49 pm
1 stop7h 49m
Mazatlán Gen Rafael Buelna
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$309
Des MoinesLeón
DSM Des Moines - BJX León Del Bajio
DSMBJX
Des Moines
Thu 12/3
8:35 pm-4:08 pm
3 stops43h 33m
León Del Bajio
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$309
Des MoinesCancún
DSM Des Moines - CUN Cancun
DSMCUN
Des Moines
Thu 12/31
6:00 am-1:34 pm
1 stop6h 34m
Cancun
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$317
Des MoinesMazatlán
DSM Des Moines - MZT Mazatlán Gen Rafael Buelna
DSMMZT
Des Moines
Thu 11/26
8:28 pm-4:37 pm
2 stops45h 09m
Mazatlán Gen Rafael Buelna
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$320
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mexico
Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
DSM-MEX
DSM-CUN
DSM-GDL
DSM-CZM
DSM-SJD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico
DSM-MX0
DSM-MEX
DSM-CUN
DSM-GDL
DSM-CZM
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $613). Flying from Des Moines to Mexico in December is currently the most expensive (average of $762). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How far ahead should I book a flight from Des Moines to Mexico?
Booking 17 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Mexico. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Reviews of airlines servicing Mexico
Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated November 4, 2026.
See what other customers who have flown with Southwest,Delta, andAeromexico from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Overall
8.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Food
7.0
Overall
8.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Food
7.0
Overall
8.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Food
7.0
Overall
8.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Food
7.0
Overall
8.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Food
7.0
Overall
8.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mexico
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Complete your trip
Complete your trip to Mexico by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Mexico, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Mexico flights
Browse other Des Moines and Mexico flight options. Last updated on November 4, 2026.
Popular flight searches
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Top 5 airlines flying from Des Moines to Mexico
Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$288 | Average$620 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$459 | Average$707 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$465 | Average$653 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$473 | Average$701 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$569 | Average$772 | FlexibilityNo cancel fee | On-time63% |