$175+ Cheap flights from Des Moines (DSM) to Mexico
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
May 5 — May 121
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 5, 2026.
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 5, 2026.
This Expedia deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:16 pm
DSM
- CUN
1 stop21h 48m
Frontier
Sun 5/103:39 pm
CUN
- DSM
1 stop21h 52m
Frontier
Deal found 3/31![Frontier logo]()
$331
This FlightHub deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- CUN
1 stop21h 48m
Frontier
Mon 5/1111:05 am
CUN
- DSM
2 stops50h 26m
Frontier
Deal found 4/2![Frontier logo]()
$392
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:16 pm
DSM
- CUN
2 stops43h 23m
Multiple Airlines
Thu 5/2110:30 am
CUN
- DSM
1 stop12h 01m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$396
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:45 am
DSM
- CUN
2 stops26h 10m
Multiple Airlines
Thu 5/2110:30 am
CUN
- DSM
1 stop12h 01m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$404
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:03 pm
DSM
- CUN
1 stop16h 05m
American Airlines
Sat 5/231:08 pm
CUN
- DSM
1 stop11h 04m
American Airlines
Deal found 4/1![American Airlines logo]()
$412
This Justfly.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:16 pm
DSM
- CUN
1 stop21h 48m
Frontier
Sun 6/143:35 pm
CUN
- DSM
1 stop21h 56m
Frontier
Deal found 3/31![Frontier logo]()
$414
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/178:03 pm
DSM
- CUN
1 stop16h 05m
American Airlines
Sun 5/2412:30 pm
CUN
- DSM
1 stop10h 38m
American Airlines
Deal found 4/2![American Airlines logo]()
$419
This Rumbo deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Rumbo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:33 pm
DSM
- CUN
1 stop5h 43m
Aeromexico
Fri 5/228:00 am
CUN
- DSM
1 stop9h 53m
Aeromexico
Deal found 3/31![Aeromexico logo]()
$420
This Aeromexico deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:27 am
DSM
- CUN
1 stop14h 49m
Aeromexico
Thu 5/141:45 pm
CUN
- DSM
1 stop8h 47m
Aeromexico
Deal found 4/2![Aeromexico logo]()
$422
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:03 pm
DSM
- CUN
1 stop14h 49m
American Airlines
Wed 5/2012:10 pm
CUN
- DSM
1 stop10h 08m
American Airlines
Deal found 3/31![American Airlines logo]()
$423
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/32:36 pm
DSM
- CUN
1 stop20h 41m
Multiple Airlines
Sun 5/1012:22 pm
CUN
- DSM
2 stops34h 35m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$428
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- GDL
2 stops31h 41m
Multiple Airlines
Fri 5/810:25 am
GDL
- DSM
1 stop9h 46m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$462
Best flights from Des Moines to MexicoDiscover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 5, 2026.
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/911:00 am
DSM
- GDL
2 stops30h 47m
Multiple Airlines
Sun 5/177:59 am
GDL
- DSM
1 stop28h 32m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$542
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:01 am
DSM
- CUN
2 stops12h 42m
Delta
Fri 5/158:08 am
CUN
- DSM
2 stops14h 24m
Delta
Deal found 4/1![Delta logo]()
$565
This Aeromexico deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:27 am
DSM
- PVR
1 stop8h 04m
Aeromexico
Fri 5/151:41 pm
PVR
- DSM
1 stop7h 51m
Aeromexico
Deal found 4/3![Aeromexico logo]()
$592
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:00 am
DSM
- BJX
1 stop8h 34m
American Airlines
Sat 5/236:19 am
BJX
- DSM
1 stop25h 52m
American Airlines
Deal found 4/1![American Airlines logo]()
$606
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:25 pm
DSM
- PVR
2 stops15h 45m
United Airlines
Sun 5/1012:19 pm
PVR
- DSM
2 stops11h 20m
United Airlines
Deal found 3/31![United Airlines logo]()
$649
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/111:42 am
DSM
- CUN
1 stop8h 43m
Delta
Wed 7/810:55 am
CUN
- DSM
1 stop11h 34m
Delta
Deal found 3/31![Delta logo]()
$569
This Aeromexico deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/265:45 am
DSM
- PVR
2 stops18h 28m
Aeromexico
Thu 4/301:06 pm
PVR
- DSM
1 stop8h 28m
Aeromexico
Deal found 3/30![Aeromexico logo]()
$594
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:05 pm
DSM
- MLM
1 stop18h 24m
American Airlines
Sat 5/2312:03 pm
MLM
- DSM
1 stop27h 00m
American Airlines
Deal found 4/1![American Airlines logo]()
$609
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:00 am
DSM
- CUN
2 stops13h 15m
Delta
Sat 5/98:08 am
CUN
- DSM
2 stops14h 24m
Delta
Deal found 4/1![Delta logo]()
$571
This United Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/199:06 am
DSM
- GDL
2 stops13h 28m
United Airlines
Sun 5/246:40 am
GDL
- DSM
1 stop6h 40m
United Airlines
Deal found 4/3![United Airlines logo]()
$657
This Aeromexico deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:45 am
DSM
- BJX
2 stops28h 04m
Aeromexico
Mon 5/116:52 pm
BJX
- DSM
2 stops22h 01m
Aeromexico
Deal found 4/4![Aeromexico logo]()
$620
This Delta deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2210:26 am
DSM
- CUN
2 stops9h 50m
Delta
Tue 5/268:00 am
CUN
- DSM
2 stops12h 36m
Delta
Deal found 4/3![Delta logo]()
$579
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/54:13 pm
DSM
- PVR
2 stops21h 02m
American Airlines
Sat 9/1211:41 am
PVR
- DSM
1 stop10h 26m
American Airlines
Deal found 4/2![American Airlines logo]()
$642
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/59:14 am
DSM
- SJD
1 stop6h 29m
United Airlines
Wed 6/101:44 pm
SJD
- DSM
1 stop6h 51m
United Airlines
Deal found 4/2![United Airlines logo]()
$667
This Aeromexico deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:45 am
DSM
- GDL
1 stop6h 52m
Aeromexico
Wed 5/61:02 pm
GDL
- DSM
1 stop8h 32m
Aeromexico
Deal found 4/1![Aeromexico logo]()
$627
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:00 am
DSM
- BJX
1 stop15h 59m
American Airlines
Sun 5/171:38 pm
BJX
- DSM
1 stop9h 21m
American Airlines
Deal found 4/1![American Airlines logo]()
$645
This Delta deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2511:04 am
DSM
- CUN
1 stop9h 11m
Delta
Wed 9/306:03 am
CUN
- DSM
2 stops11h 39m
Delta
Deal found 4/3![Delta logo]()
$593
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/55:50 am
DSM
- PVR
1 stop8h 03m
United Airlines
Sat 7/1112:19 pm
PVR
- DSM
1 stop8h 21m
United Airlines
Deal found 4/2![United Airlines logo]()
$667
This Aeromexico deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:44 pm
DSM
- PVR
2 stops21h 32m
Aeromexico
Wed 5/68:48 am
PVR
- DSM
2 stops12h 46m
Aeromexico
Deal found 3/31![Aeromexico logo]()
$638
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/412:06 pm
DSM
- BJX
1 stop25h 27m
American Airlines
Mon 5/111:38 pm
BJX
- DSM
1 stop9h 21m
American Airlines
Deal found 4/4![American Airlines logo]()
$652
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:05 am
DSM
- CUN
1 stop6h 00m
Delta
Sat 7/188:00 am
CUN
- DSM
1 stop7h 57m
Delta
Deal found 4/1![Delta logo]()
$593
This United Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:20 am
DSM
- MLM
1 stop10h 53m
United Airlines
Wed 5/136:50 am
MLM
- DSM
1 stop14h 55m
United Airlines
Deal found 4/3![United Airlines logo]()
$674
This Aeromexico deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:57 am
DSM
- BJX
1 stop7h 07m
Aeromexico
Sun 5/179:24 am
BJX
- DSM
1 stop12h 08m
Aeromexico
Deal found 3/31![Aeromexico logo]()
$642
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:25 am
DSM
- MEX
2 stops11h 05m
Delta
Thu 7/96:10 pm
MEX
- DSM
2 stops15h 35m
Delta
Deal found 4/4![Delta logo]()
$605
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:00 am
DSM
- MLM
1 stop8h 29m
American Airlines
Sun 5/2412:03 pm
MLM
- DSM
1 stop10h 54m
American Airlines
Deal found 4/2![American Airlines logo]()
$668
This United Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:51 pm
DSM
- CZM
2 stops20h 51m
United Airlines
Sat 8/153:52 pm
CZM
- DSM
1 stop5h 34m
United Airlines
Deal found 4/3![United Airlines logo]()
$676
This Aeromexico deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/312:48 pm
DSM
- MEX
1 stop8h 11m
Aeromexico
Sat 8/157:55 pm
MEX
- DSM
2 stops25h 31m
Aeromexico
Deal found 3/31![Aeromexico logo]()
$662
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:43 am
DSM
- MEX
2 stops9h 47m
Delta
Mon 7/65:25 pm
MEX
- DSM
2 stops15h 48m
Delta
Deal found 3/31![Delta logo]()
$607
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:13 pm
DSM
- MTY
1 stop15h 14m
American Airlines
Sat 8/15:22 pm
MTY
- DSM
1 stop6h 07m
American Airlines
Deal found 4/4![American Airlines logo]()
$668
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1610:02 am
DSM
- GDL
2 stops12h 32m
United Airlines
Sun 5/312:30 pm
GDL
- DSM
1 stop7h 05m
United Airlines
Deal found 4/1![United Airlines logo]()
$677
Last-minute flights from Des Moines to MexicoDiscover last-minute flight deals from Des Moines to Mexico. Data last updated April 5, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico. Data last updated April 5, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- GDL
2 stops31h 41m
Multiple Airlines
Fri 5/810:25 am
GDL
- DSM
1 stop9h 46m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$462
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/32:36 pm
DSM
- CUN
1 stop20h 41m
Multiple Airlines
Sun 5/1012:22 pm
CUN
- DSM
2 stops34h 35m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$428
This Expedia deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:16 pm
DSM
- CUN
1 stop21h 48m
Frontier
Sun 5/103:39 pm
CUN
- DSM
1 stop21h 52m
Frontier
Deal found 3/31![Frontier logo]()
$331
This FlightHub deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- CUN
1 stop21h 48m
Frontier
Mon 5/1111:05 am
CUN
- DSM
2 stops50h 26m
Frontier
Deal found 4/2![Frontier logo]()
$392
This Aeromexico deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:27 am
DSM
- CUN
1 stop14h 49m
Aeromexico
Thu 5/141:45 pm
CUN
- DSM
1 stop8h 47m
Aeromexico
Deal found 4/2![Aeromexico logo]()
$422
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:16 pm
DSM
- CUN
2 stops43h 23m
Multiple Airlines
Thu 5/2110:30 am
CUN
- DSM
1 stop12h 01m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$396
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:45 am
DSM
- CUN
2 stops26h 10m
Multiple Airlines
Thu 5/2110:30 am
CUN
- DSM
1 stop12h 01m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$404
This Rumbo deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Rumbo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:33 pm
DSM
- CUN
1 stop5h 43m
Aeromexico
Fri 5/228:00 am
CUN
- DSM
1 stop9h 53m
Aeromexico
Deal found 3/31![Aeromexico logo]()
$420
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:03 pm
DSM
- CUN
1 stop16h 05m
American Airlines
Sat 5/231:08 pm
CUN
- DSM
1 stop11h 04m
American Airlines
Deal found 4/1![American Airlines logo]()
$412
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:03 pm
DSM
- CUN
1 stop14h 49m
American Airlines
Wed 5/2012:10 pm
CUN
- DSM
1 stop10h 08m
American Airlines
Deal found 3/31![American Airlines logo]()
$423
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/178:03 pm
DSM
- CUN
1 stop16h 05m
American Airlines
Sun 5/2412:30 pm
CUN
- DSM
1 stop10h 38m
American Airlines
Deal found 4/2![American Airlines logo]()
$419
This FlightHub deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- CUN
1 stop21h 48m
Frontier
Tue 6/23:22 pm
CUN
- DSM
2 stops22h 09m
Frontier
Deal found 4/3![Frontier logo]()
$429
One-way flights from Des Moines to MexicoSearch for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated April 5, 2026.
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated April 5, 2026.
This Priceline deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:14 pm
DSM
- CUN
1 stop18h 25m
Frontier
Deal found 4/3![Frontier logo]()
$175
This Priceline deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/152:16 pm
DSM
- CUN
1 stop21h 52m
Frontier
Deal found 3/31![Frontier logo]()
$186
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1710:14 pm
DSM
- GDL
2 stops31h 39m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:45 am
DSM
- CUN
1 stop27h 32m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/89:56 pm
DSM
- GDL
2 stops27h 03m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/59:56 pm
DSM
- GDL
2 stops32h 09m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/122:36 pm
DSM
- CUN
1 stop20h 54m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/78:36 pm
DSM
- GDL
1 stop22h 44m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2410:14 pm
DSM
- PVR
2 stops44h 26m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:32 pm
DSM
- CUN
2 stops33h 43m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$253
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:13 pm
DSM
- MEX
1 stop5h 35m
American Airlines
Deal found 4/3![American Airlines logo]()
$264
Find flight deals from Des Moines to Mexico
Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated April 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $331 (Expedia) |
One-way from | $175 (Priceline) |
Popular in | December |
Cheapest in | August |
Average price | $509 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 5, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Sat 5/9
11:00 am-4:47 pm
2 stops30h 47m
Guadalajara Miguel Hidal
Sun 5/17
7:59 am-1:31 pm
1 stop28h 32m
$542
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 5/8
7:01 am-7:43 pm
2 stops12h 42m
Cancun
Fri 5/15
8:08 am-10:32 pm
2 stops14h 24m
$565
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 7/1
11:42 am-8:25 pm
1 stop8h 43m
Cancun
Wed 7/8
10:55 am-10:29 pm
1 stop11h 34m
$569
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Sat 5/2
7:00 am-8:15 pm
2 stops13h 15m
Cancun
Sat 5/9
8:08 am-10:32 pm
2 stops14h 24m
$571
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 5/22
10:26 am-8:16 pm
2 stops9h 50m
Cancun
Tue 5/26
8:00 am-8:36 pm
2 stops12h 36m
$579
Des MoinesPuerto Vallarta
DSM - PVR
DSMPVR
Des Moines
Tue 5/12
5:27 am-12:31 pm
1 stop8h 04m
Puerto Vallarta Ordaz
Fri 5/15
1:41 pm-10:32 pm
1 stop7h 51m
$592
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 9/25
11:04 am-8:15 pm
1 stop9h 11m
Cancun
Wed 9/30
6:03 am-5:42 pm
2 stops11h 39m
$593
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Tue 7/14
7:05 am-1:05 pm
1 stop6h 00m
Cancun
Sat 7/18
8:00 am-3:57 pm
1 stop7h 57m
$593
Des MoinesPuerto Vallarta
DSM - PVR
DSMPVR
Des Moines
Sun 4/26
5:45 am-11:13 pm
2 stops18h 28m
Puerto Vallarta Ordaz
Thu 4/30
1:06 pm-10:34 pm
1 stop8h 28m
$594
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Wed 6/24
5:25 am-3:30 pm
2 stops11h 05m
Mexico City Benito Juarez
Thu 7/9
6:10 pm-10:45 am
2 stops15h 35m
$605
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mexico
Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
DSM-CUN
DSM-GDL
DSM-MEX
DSM-PVR
DSM-SJD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico
DSM-MX0
DSM-CUN
DSM-GDL
DSM-MEX
DSM-PVR
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, October is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $241). Flying from Des Moines to Mexico in June is currently the most expensive (average of $454). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Mexico
Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated April 5, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mexico
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Complete your trip
Complete your trip to Mexico by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and Mexico flights
Browse other Des Moines and Mexico flight options. Last updated on April 5, 2026.
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Des Moines to Mexico flights
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Consider these flights traveling to Mexico regions.
Top 5 airlines flying from Des Moines to Mexico
Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$276 | Average$480 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$366 | Average$658 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$379 | Average$658 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$397 | Average$619 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$569 | Average$712 | FlexibilityNo cancel fee | On-time63% |