$157+ Cheap flights from Des Moines (DSM) to Mexico
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/8. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
May 23 — May 301
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/32:16 pm
DSM
- CUN
1 stop21h 52m
Multiple Airlines
Thu 8/610:25 am
CUN
- DSM
1 stop11h 06m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$381
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:37 pm
DSM
- CUN
1 stop17h 43m
Multiple Airlines
Thu 6/1110:25 am
CUN
- DSM
1 stop11h 02m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/303:37 pm
DSM
- CUN
2 stops22h 36m
Multiple Airlines
Thu 8/610:25 am
CUN
- DSM
1 stop11h 06m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$425
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Wed 6/177:35 pm
GDL
- DSM
2 stops40h 56m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$456
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/62:16 pm
DSM
- GDL
1 stop10h 54m
Multiple Airlines
Wed 7/225:30 pm
GDL
- DSM
2 stops26h 57m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$464
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/52:16 pm
DSM
- MTY
1 stop28h 49m
Multiple Airlines
Fri 6/1212:05 pm
MTY
- DSM
1 stop8h 01m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$464
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Sun 6/711:00 am
MEX
- DSM
2 stops34h 32m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$469
This Priceline deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:16 pm
DSM
- MEX
1 stop28h 14m
Frontier
Tue 7/218:40 am
MEX
- DSM
1 stop27h 51m
Frontier
Deal found 4/21![Frontier logo]()
$472
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/102:16 pm
DSM
- GDL
1 stop10h 54m
Multiple Airlines
Wed 7/225:30 pm
GDL
- DSM
2 stops26h 57m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$475
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/62:16 pm
DSM
- GDL
1 stop10h 54m
Multiple Airlines
Mon 7/205:50 am
GDL
- DSM
1 stop12h 14m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$480
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/129:33 pm
DSM
- GDL
1 stop21h 47m
Multiple Airlines
Wed 7/225:30 pm
GDL
- DSM
2 stops26h 57m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$486
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/102:16 pm
DSM
- GDL
1 stop10h 54m
Multiple Airlines
Mon 7/205:50 am
GDL
- DSM
1 stop12h 14m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$491
Best flights from Des Moines to MexicoDiscover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/52:16 pm
DSM
- MTY
1 stop28h 49m
Multiple Airlines
Fri 6/1212:05 pm
MTY
- DSM
1 stop8h 01m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$464
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/252:15 pm
DSM
- CUN
1 stop6h 00m
Delta
Wed 9/308:00 am
CUN
- DSM
2 stops14h 26m
Delta
Deal found 4/21![Delta logo]()
$519
This Justfly.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/122:16 pm
DSM
- GDL
1 stop11h 16m
Frontier
Tue 6/168:46 am
GDL
- DSM
2 stops27h 45m
Frontier
Deal found 4/19![Frontier logo]()
$543
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:20 am
DSM
- MLM
1 stop12h 53m
United Airlines
Thu 8/206:50 am
MLM
- DSM
1 stop6h 27m
United Airlines
Deal found 4/20![United Airlines logo]()
$637
This Aeromexico deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:45 am
DSM
- BJX
1 stop13h 25m
Aeromexico
Wed 9/25:55 am
BJX
- DSM
2 stops10h 47m
Aeromexico
Deal found 4/20![Aeromexico logo]()
$640
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:25 am
DSM
- SJD
1 stop9h 00m
Southwest
Tue 7/2112:50 pm
SJD
- DSM
1 stop6h 50m
Southwest
Deal found 4/19![Southwest logo]()
$642
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/17:13 pm
DSM
- MEX
1 stop16h 04m
American Airlines
Thu 8/135:00 am
MEX
- DSM
1 stop9h 12m
American Airlines
Deal found 4/18![American Airlines logo]()
$642
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/52:16 pm
DSM
- GDL
1 stop11h 16m
Multiple Airlines
Fri 6/1210:25 am
GDL
- DSM
1 stop9h 41m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$515
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/147:00 am
DSM
- CUN
2 stops12h 31m
Delta
Wed 8/1912:35 pm
CUN
- DSM
1 stop8h 10m
Delta
Deal found 4/21![Delta logo]()
$519
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/296:07 am
DSM
- CUN
1 stop6h 58m
Delta
Wed 7/82:10 pm
CUN
- DSM
1 stop8h 19m
Delta
Deal found 4/22![Delta logo]()
$568
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/113:37 pm
DSM
- GDL
2 stops26h 31m
Multiple Airlines
Thu 6/1810:25 am
GDL
- DSM
1 stop8h 21m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$581
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/76:20 am
DSM
- PVR
1 stop8h 36m
United Airlines
Fri 6/122:52 pm
PVR
- DSM
1 stop6h 43m
United Airlines
Deal found 4/22![United Airlines logo]()
$642
This Aeromexico deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:45 am
DSM
- PVR
1 stop7h 26m
Aeromexico
Fri 10/21:21 pm
PVR
- DSM
1 stop8h 05m
Aeromexico
Deal found 4/18![Aeromexico logo]()
$642
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/77:02 pm
DSM
- PVR
1 stop16h 36m
American Airlines
Fri 6/123:01 pm
PVR
- DSM
2 stops17h 10m
American Airlines
Deal found 4/22![American Airlines logo]()
$647
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:01 am
DSM
- CUN
2 stops13h 15m
Delta
Tue 6/28:09 am
CUN
- DSM
2 stops14h 23m
Delta
Deal found 4/18![Delta logo]()
$572
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:20 am
DSM
- GDL
1 stop8h 14m
United Airlines
Thu 6/1812:30 pm
GDL
- DSM
1 stop9h 05m
United Airlines
Deal found 4/18![United Airlines logo]()
$653
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/64:48 pm
DSM
- MLM
1 stop19h 15m
American Airlines
Sat 6/1312:11 pm
MLM
- DSM
1 stop10h 47m
American Airlines
Deal found 4/22![American Airlines logo]()
$660
This Aeromexico deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:27 am
DSM
- PVR
1 stop8h 04m
Aeromexico
Thu 5/288:48 am
PVR
- DSM
2 stops12h 44m
Aeromexico
Deal found 4/18![Aeromexico logo]()
$662
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:15 pm
DSM
- CUN
1 stop5h 53m
Delta
Wed 8/198:00 am
CUN
- DSM
2 stops12h 45m
Delta
Deal found 4/18![Delta logo]()
$572
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/128:00 am
DSM
- MLM
2 stops11h 13m
United Airlines
Thu 8/206:50 am
MLM
- DSM
2 stops13h 22m
United Airlines
Deal found 4/20![United Airlines logo]()
$656
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/54:13 pm
DSM
- PVR
1 stop21h 04m
American Airlines
Sat 9/1211:41 am
PVR
- DSM
1 stop10h 26m
American Airlines
Deal found 4/19![American Airlines logo]()
$678
This Aeromexico deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:15 pm
DSM
- MTY
2 stops19h 35m
Aeromexico
Fri 8/2811:50 am
MTY
- DSM
1 stop9h 36m
Aeromexico
Deal found 4/20![Aeromexico logo]()
$679
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/295:45 am
DSM
- SJD
1 stop7h 25m
Delta
Fri 10/26:04 am
SJD
- DSM
2 stops14h 22m
Delta
Deal found 4/22![Delta logo]()
$580
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:00 am
DSM
- SJD
2 stops9h 48m
United Airlines
Sat 7/1110:00 am
SJD
- DSM
1 stop10h 35m
United Airlines
Deal found 4/18![United Airlines logo]()
$667
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:13 pm
DSM
- MTY
1 stop17h 32m
American Airlines
Sat 8/15:22 pm
MTY
- DSM
1 stop14h 49m
American Airlines
Deal found 4/18![American Airlines logo]()
$690
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:05 am
DSM
- CUN
2 stops13h 10m
Delta
Sun 7/198:00 am
CUN
- DSM
1 stop9h 53m
Delta
Deal found 4/18![Delta logo]()
$597
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:50 pm
DSM
- SJD
2 stops16h 02m
United Airlines
Sat 5/3011:32 am
SJD
- DSM
1 stop9h 03m
United Airlines
Deal found 4/18![United Airlines logo]()
$667
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:00 am
DSM
- BJX
1 stop15h 59m
American Airlines
Sun 5/2410:54 am
BJX
- DSM
1 stop12h 03m
American Airlines
Deal found 4/18![American Airlines logo]()
$695
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:01 am
DSM
- CUN
2 stops13h 15m
Delta
Wed 5/208:00 am
CUN
- DSM
1 stop14h 32m
Delta
Deal found 4/18![Delta logo]()
$597
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:15 am
DSM
- PVR
1 stop5h 55m
United Airlines
Sat 10/172:52 pm
PVR
- DSM
1 stop6h 31m
United Airlines
Deal found 4/20![United Airlines logo]()
$667
Last-minute flights from Des Moines to MexicoDiscover last-minute flight deals from Des Moines to Mexico. Data last updated April 23, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico. Data last updated April 23, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:51 pm
DSM
- MEX
2 stops31h 39m
Multiple Airlines
Sun 5/311:00 am
MEX
- DSM
1 stop31h 25m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$540
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:00 am
DSM
- MEX
1 stop10h 05m
Multiple Airlines
Thu 5/711:05 am
MEX
- DSM
2 stops34h 52m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$590
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:05 pm
DSM
- CUN
1 stop16h 00m
American Airlines
Wed 5/2012:05 pm
CUN
- DSM
1 stop11h 54m
American Airlines
Deal found 4/21![American Airlines logo]()
$532
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:00 am
DSM
- CUN
2 stops22h 15m
Multiple Airlines
Sun 5/2410:30 am
CUN
- DSM
1 stop12h 01m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$570
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:45 am
DSM
- CUN
1 stop27h 32m
Multiple Airlines
Sun 5/241:14 pm
CUN
- DSM
2 stops34h 10m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$517
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:01 am
DSM
- BJX
2 stops17h 06m
Delta
Tue 5/269:34 am
BJX
- DSM
1 stop11h 58m
Delta
Deal found 4/21![Delta logo]()
$620
This Aeromexico deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:01 am
DSM
- BJX
2 stops11h 11m
Aeromexico
Sun 5/249:34 am
BJX
- DSM
1 stop11h 58m
Aeromexico
Deal found 4/20![Aeromexico logo]()
$640
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/249:00 am
DSM
- MTY
1 stop7h 05m
Multiple Airlines
Mon 5/258:37 pm
MTY
- DSM
2 stops39h 22m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$533
This FlightHub deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- CUN
1 stop21h 48m
Frontier
Tue 6/23:39 pm
CUN
- DSM
1 stop21h 52m
Frontier
Deal found 4/20![Frontier logo]()
$509
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:33 pm
DSM
- CUN
1 stop5h 43m
Delta
Tue 6/29:18 am
CUN
- DSM
2 stops13h 14m
Delta
Deal found 4/19![Delta logo]()
$550
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Mon 6/111:00 am
MEX
- DSM
1 stop8h 27m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$521
This Priceline deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- MEX
2 stops32h 59m
Frontier
Mon 6/14:10 pm
MEX
- DSM
2 stops44h 21m
Frontier
Deal found 4/21![Frontier logo]()
$587
One-way flights from Des Moines to MexicoSearch for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:00 am
DSM
- MEX
1 stop17h 15m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:16 pm
DSM
- GDL
2 stops34h 43m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/62:16 pm
DSM
- GDL
1 stop10h 54m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:16 pm
DSM
- BJX
3 stops20h 30m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/78:36 pm
DSM
- GDL
1 stop22h 44m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/29:33 pm
DSM
- MTY
1 stop19h 42m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:16 pm
DSM
- CUN
2 stops42h 59m
Frontier
Deal found 4/20![Frontier logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:02 pm
DSM
- BJX
3 stops48h 08m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/52:16 pm
DSM
- BJX
2 stops44h 14m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$237
Find flight deals from Des Moines to Mexico
Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated April 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $381 (Kiwi.com) |
One-way from | $157 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $582 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMonterrey
DSM - MTY
DSMMTY
Des Moines
Fri 6/5
2:16 pm-6:05 pm
1 stop28h 49m
Monterrey Gen Mariano Escobedo
Fri 6/12
12:05 pm-9:06 pm
1 stop8h 01m
$464
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Fri 6/5
2:16 pm-12:32 am
1 stop11h 16m
Guadalajara Miguel Hidal
Fri 6/12
10:25 am-9:06 pm
1 stop9h 41m
$515
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 9/25
2:15 pm-8:15 pm
1 stop6h 00m
Cancun
Wed 9/30
8:00 am-10:26 pm
2 stops14h 26m
$519
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 8/14
7:00 am-7:31 pm
2 stops12h 31m
Cancun
Wed 8/19
12:35 pm-8:45 pm
1 stop8h 10m
$519
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Fri 6/12
2:16 pm-12:32 am
1 stop11h 16m
Guadalajara Miguel Hidal
Tue 6/16
8:46 am-1:31 pm
2 stops27h 45m
$543
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Mon 6/29
6:07 am-1:05 pm
1 stop6h 58m
Cancun
Wed 7/8
2:10 pm-10:29 pm
1 stop8h 19m
$568
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 5/27
7:01 am-8:16 pm
2 stops13h 15m
Cancun
Tue 6/2
8:09 am-10:32 pm
2 stops14h 23m
$572
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 8/12
2:15 pm-8:08 pm
1 stop5h 53m
Cancun
Wed 8/19
8:00 am-8:45 pm
2 stops12h 45m
$572
Des MoinesSan José del Cabo
DSM - SJD
DSMSJD
Des Moines
Tue 9/29
5:45 am-11:10 am
1 stop7h 25m
San José del Cabo Los Cabos
Fri 10/2
6:04 am-10:26 pm
2 stops14h 22m
$580
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Thu 6/11
3:37 pm-5:08 pm
2 stops26h 31m
Guadalajara Miguel Hidal
Thu 6/18
10:25 am-7:46 pm
1 stop8h 21m
$581
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mexico
Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
DSM-MTY
DSM-CUN
DSM-GDL
DSM-MLM
DSM-BJX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico
DSM-MX0
DSM-MTY
DSM-CUN
DSM-GDL
DSM-MLM
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, May is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $192). Flying from Des Moines to Mexico in August is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Mexico
Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated April 23, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Des Moines and Mexico flights
Browse other Des Moines and Mexico flight options. Last updated on April 23, 2026.
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Des Moines to Mexico flights
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Top 5 airlines flying from Des Moines to Mexico
Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$276 | Average$481 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$379 | Average$669 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$382 | Average$688 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$397 | Average$622 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$547 | Average$697 | FlexibilityNo cancel fee | On-time63% |