$187+ Cheap flights from Des Moines (DSM) to Mexico
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/6. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
May 29 — Jun 51
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CUN
1 stop16h 39m
Multiple Airlines
Thu 6/410:30 am
CUN
- DSM
1 stop10h 57m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$393
This Justfly.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- CUN
1 stop21h 48m
Frontier
Tue 6/23:39 pm
CUN
- DSM
1 stop21h 52m
Frontier
Deal found 4/27![Frontier logo]()
$412
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Mon 6/1510:45 pm
MEX
- DSM
2 stops37h 46m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$425
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/113:37 pm
DSM
- CUN
1 stop17h 48m
Multiple Airlines
Thu 6/183:35 pm
CUN
- DSM
1 stop21h 56m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$430
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:41 pm
DSM
- CUN
1 stop16h 39m
Multiple Airlines
Sun 5/311:31 pm
CUN
- DSM
2 stops33h 53m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$441
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/122:16 pm
DSM
- MTY
1 stop28h 49m
Multiple Airlines
Fri 6/197:35 pm
MTY
- DSM
2 stops50h 17m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$443
This FlightHub deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:16 pm
DSM
- CUN
1 stop21h 52m
Frontier
Sun 8/303:35 pm
CUN
- DSM
1 stop21h 56m
Frontier
Deal found 4/27![Frontier logo]()
$453
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:02 pm
DSM
- CUN
1 stop16h 23m
Multiple Airlines
Fri 7/37:00 am
CUN
- DSM
2 stops14h 11m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$455
This Orbitz deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- CUN
1 stop22h 32m
Frontier
Tue 6/93:01 pm
CUN
- DSM
2 stops22h 30m
Frontier
Deal found 4/27![Frontier logo]()
$458
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Wed 6/1710:40 pm
MEX
- DSM
2 stops37h 51m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$459
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:16 pm
DSM
- GDL
1 stop27h 09m
Multiple Airlines
Wed 6/175:30 pm
GDL
- DSM
2 stops43h 01m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$460
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Sun 6/76:20 am
MEX
- DSM
2 stops40h 07m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$468
Best flights from Des Moines to MexicoDiscover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 29, 2026.
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Mon 6/1510:45 pm
MEX
- DSM
2 stops37h 46m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$425
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:26 am
DSM
- CUN
2 stops9h 50m
Delta
Tue 6/29:18 am
CUN
- DSM
2 stops13h 14m
Delta
Deal found 4/25![Delta logo]()
$554
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/165:00 am
DSM
- SJD
2 stops9h 48m
United Airlines
Thu 8/271:17 pm
SJD
- DSM
1 stop8h 38m
United Airlines
Deal found 4/26![United Airlines logo]()
$592
This Southwest deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:20 am
DSM
- CUN
2 stops8h 40m
Southwest
Tue 6/1611:40 am
CUN
- DSM
2 stops11h 05m
Southwest
Deal found 4/24![Southwest logo]()
$597
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:30 am
DSM
- PVR
1 stop6h 08m
American Airlines
Mon 6/151:23 pm
PVR
- DSM
1 stop25h 40m
American Airlines
Deal found 4/24![American Airlines logo]()
$612
This Aeromexico deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:00 am
DSM
- BJX
2 stops10h 29m
Aeromexico
Mon 8/318:10 pm
BJX
- DSM
2 stops20h 32m
Aeromexico
Deal found 4/27![Aeromexico logo]()
$620
This Kissandfly.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:20 am
DSM
- MID
1 stop12h 45m
Lufthansa
Wed 6/177:00 am
MID
- DSM
1 stop6h 20m
Lufthansa
Deal found 4/26![Lufthansa logo]()
$713
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- MTY
1 stop28h 49m
Multiple Airlines
Mon 6/1512:05 pm
MTY
- DSM
1 stop8h 01m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$475
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1010:24 am
DSM
- CUN
2 stops10h 01m
Delta
Wed 6/178:00 am
CUN
- DSM
1 stop14h 31m
Delta
Deal found 4/27![Delta logo]()
$572
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- CUN
1 stop22h 32m
Multiple Airlines
Mon 6/159:10 pm
CUN
- DSM
2 stops40h 21m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$525
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:25 am
DSM
- CUN
2 stops8h 45m
Southwest
Thu 6/41:20 pm
CUN
- DSM
1 stop10h 10m
Southwest
Deal found 4/29![Southwest logo]()
$597
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:30 am
DSM
- MID
1 stop8h 22m
American Airlines
Mon 6/151:34 pm
MID
- DSM
1 stop27h 48m
American Airlines
Deal found 4/24![American Airlines logo]()
$622
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:57 am
DSM
- CUN
1 stop8h 19m
Delta
Wed 5/208:00 am
CUN
- DSM
2 stops12h 36m
Delta
Deal found 4/24![Delta logo]()
$579
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/218:30 pm
DSM
- PVR
2 stops15h 40m
United Airlines
Fri 8/2812:19 pm
PVR
- DSM
2 stops10h 36m
United Airlines
Deal found 4/25![United Airlines logo]()
$647
This Aeromexico deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:27 am
DSM
- PVR
1 stop8h 04m
Aeromexico
Thu 5/288:48 am
PVR
- DSM
2 stops12h 44m
Aeromexico
Deal found 4/26![Aeromexico logo]()
$662
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:35 am
DSM
- CUN
1 stop7h 05m
Southwest
Tue 10/132:45 pm
CUN
- DSM
1 stop7h 05m
Southwest
Deal found 4/27![Southwest logo]()
$623
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:20 am
DSM
- GDL
1 stop6h 05m
United Airlines
Thu 6/185:00 am
GDL
- DSM
1 stop13h 25m
United Airlines
Deal found 4/27![United Airlines logo]()
$652
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/54:13 pm
DSM
- PVR
1 stop19h 23m
American Airlines
Sat 9/122:00 pm
PVR
- DSM
1 stop8h 52m
American Airlines
Deal found 4/29![American Airlines logo]()
$652
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:00 am
DSM
- CUN
2 stops10h 29m
Delta
Sat 8/298:30 am
CUN
- DSM
2 stops13h 56m
Delta
Deal found 4/27![Delta logo]()
$593
This Aeromexico deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/315:45 am
DSM
- MTY
2 stops13h 09m
Aeromexico
Fri 9/45:46 am
MTY
- DSM
2 stops10h 56m
Aeromexico
Deal found 4/27![Aeromexico logo]()
$679
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:40 pm
DSM
- CUN
2 stops16h 20m
Southwest
Mon 7/612:40 pm
CUN
- DSM
2 stops10h 50m
Southwest
Deal found 4/28![Southwest logo]()
$627
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/99:00 am
DSM
- GDL
1 stop20h 53m
Multiple Airlines
Tue 6/168:46 am
GDL
- DSM
1 stop27h 09m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$648
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/74:13 pm
DSM
- MTY
1 stop18h 11m
American Airlines
Fri 8/144:28 pm
MTY
- DSM
1 stop21h 44m
American Airlines
Deal found 4/25![American Airlines logo]()
$656
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2510:15 am
DSM
- CUN
2 stops10h 00m
Delta
Wed 9/308:00 am
CUN
- DSM
2 stops12h 45m
Delta
Deal found 4/26![Delta logo]()
$597
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:00 am
DSM
- CZM
2 stops10h 42m
United Airlines
Tue 6/163:52 pm
CZM
- DSM
1 stop5h 43m
United Airlines
Deal found 4/25![United Airlines logo]()
$659
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/125:50 am
DSM
- SJD
1 stop9h 53m
United Airlines
Wed 6/1711:32 am
SJD
- DSM
1 stop9h 03m
United Airlines
Deal found 4/29![United Airlines logo]()
$667
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/295:45 am
DSM
- SJD
1 stop7h 25m
Delta
Fri 10/212:15 pm
SJD
- DSM
1 stop8h 11m
Delta
Deal found 4/28![Delta logo]()
$617
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:13 pm
DSM
- MTY
1 stop15h 14m
American Airlines
Sat 8/14:53 pm
MTY
- DSM
1 stop6h 05m
American Airlines
Deal found 4/28![American Airlines logo]()
$690
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/55:50 am
DSM
- PVR
1 stop8h 03m
United Airlines
Sat 7/111:55 pm
PVR
- DSM
1 stop8h 49m
United Airlines
Deal found 4/24![United Airlines logo]()
$667
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:27 am
DSM
- BJX
1 stop11h 17m
Delta
Wed 6/38:02 am
BJX
- DSM
2 stops13h 30m
Delta
Deal found 4/27![Delta logo]()
$620
Last-minute flights from Des Moines to MexicoDiscover last-minute flight deals from Des Moines to Mexico. Data last updated April 29, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico. Data last updated April 29, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- MEX
1 stop22h 51m
Multiple Airlines
Wed 5/208:40 am
MEX
- DSM
2 stops28h 39m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$475
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/810:01 pm
DSM
- MEX
1 stop23h 04m
Multiple Airlines
Mon 5/1111:55 am
MEX
- DSM
1 stop9h 52m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$568
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:00 am
DSM
- CUN
2 stops22h 15m
Multiple Airlines
Sun 5/243:39 pm
CUN
- DSM
1 stop21h 52m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$508
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:41 pm
DSM
- CUN
1 stop16h 39m
Multiple Airlines
Sun 5/311:31 pm
CUN
- DSM
2 stops33h 53m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$441
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/252:16 pm
DSM
- MEX
1 stop28h 14m
Multiple Airlines
Mon 6/110:45 pm
MEX
- DSM
2 stops37h 46m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$492
This FlightHub deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/252:16 pm
DSM
- MEX
2 stops32h 59m
Frontier
Mon 6/14:10 pm
MEX
- DSM
2 stops44h 21m
Frontier
Deal found 4/27![Frontier logo]()
$572
This Justfly.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- CUN
1 stop21h 48m
Frontier
Tue 6/23:39 pm
CUN
- DSM
1 stop21h 52m
Frontier
Deal found 4/27![Frontier logo]()
$412
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- GDL
1 stop27h 13m
Multiple Airlines
Wed 6/32:37 pm
GDL
- DSM
2 stops29h 50m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$476
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CUN
1 stop16h 39m
Multiple Airlines
Thu 6/410:30 am
CUN
- DSM
1 stop10h 57m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$393
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CUN
1 stop16h 39m
Multiple Airlines
Sun 5/311:31 pm
CUN
- DSM
2 stops33h 53m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$516
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- GDL
1 stop27h 13m
Multiple Airlines
Wed 6/102:37 pm
GDL
- DSM
2 stops29h 50m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$523
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- GDL
1 stop27h 13m
Multiple Airlines
Mon 6/18:46 am
GDL
- DSM
2 stops13h 02m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$542
One-way flights from Des Moines to MexicoSearch for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated April 29, 2026.
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated April 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/62:19 pm
DSM
- GDL
1 stop10h 51m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$187
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- GDL
2 stops53h 19m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- PVR
2 stops52h 29m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:16 pm
DSM
- PVR
3 stops47h 08m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$192
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/299:56 pm
DSM
- MEX
1 stop23h 09m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$196
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/59:33 pm
DSM
- GDL
1 stop23h 19m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:01 pm
DSM
- MEX
2 stops22h 59m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/82:19 pm
DSM
- GDL
1 stop27h 06m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:16 pm
DSM
- GDL
1 stop27h 13m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$232
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/32:51 pm
DSM
- GDL
2 stops29h 09m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:45 am
DSM
- MEX
2 stops40h 00m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$262
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/222:19 pm
DSM
- DGO
2 stops49h 56m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$268
Find flight deals from Des Moines to Mexico
Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated April 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $393 (Kiwi.com) |
One-way from | $187 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $582 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMexico City
DSM - MEX
DSMMEX
Des Moines
Mon 6/8
2:16 pm-5:30 pm
1 stop28h 14m
Mexico City Benito Juarez
Mon 6/15
10:45 pm-1:31 pm
2 stops37h 46m
$425
Des MoinesMonterrey
DSM - MTY
DSMMTY
Des Moines
Mon 6/8
2:16 pm-6:05 pm
1 stop28h 49m
Monterrey Gen Mariano Escobedo
Mon 6/15
12:05 pm-9:06 pm
1 stop8h 01m
$475
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Mon 6/8
2:16 pm-12:48 pm
1 stop22h 32m
Cancun
Mon 6/15
9:10 pm-1:31 pm
2 stops40h 21m
$525
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 5/27
10:26 am-8:16 pm
2 stops9h 50m
Cancun
Tue 6/2
9:18 am-10:32 pm
2 stops13h 14m
$554
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 6/10
10:24 am-8:25 pm
2 stops10h 01m
Cancun
Wed 6/17
8:00 am-10:31 pm
1 stop14h 31m
$572
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Sat 5/16
11:57 am-8:16 pm
1 stop8h 19m
Cancun
Wed 5/20
8:00 am-8:36 pm
2 stops12h 36m
$579
Des MoinesSan José del Cabo
DSM - SJD
DSMSJD
Des Moines
Sun 8/16
5:00 am-12:48 pm
2 stops9h 48m
San José del Cabo Los Cabos
Thu 8/27
1:17 pm-11:55 pm
1 stop8h 38m
$592
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Mon 8/24
7:00 am-5:29 pm
2 stops10h 29m
Cancun
Sat 8/29
8:30 am-10:26 pm
2 stops13h 56m
$593
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Tue 6/9
5:20 am-2:00 pm
2 stops8h 40m
Cancun
Tue 6/16
11:40 am-10:45 pm
2 stops11h 05m
$597
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Thu 5/28
5:25 am-2:10 pm
2 stops8h 45m
Cancun
Thu 6/4
1:20 pm-11:30 pm
1 stop10h 10m
$597
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mexico
Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
DSM-MEX
DSM-CUN
DSM-SJD
DSM-PVR
DSM-BJX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico
DSM-MX0
DSM-MEX
DSM-CUN
DSM-SJD
DSM-PVR
How far ahead should I book a flight from Des Moines to Mexico?
Booking 19 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Mexico. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, May is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $192). Flying from Des Moines to Mexico in August is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Mexico
Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated April 29, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Food
7.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Food
7.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Food
7.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Food
7.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Food
7.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Food
7.0
Crew
8.6
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Des Moines and Mexico flights
Browse other Des Moines and Mexico flight options. Last updated on April 29, 2026.
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Top 5 airlines flying from Des Moines to Mexico
Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$276 | Average$520 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$379 | Average$662 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$382 | Average$664 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$397 | Average$626 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$569 | Average$697 | FlexibilityNo cancel fee | On-time63% |