$175+ Cheap flights from Des Moines (DSM) to Mexico
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEX
Aug 1 — Aug 81
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2026.
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2026.
This Priceline deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/222:19 pm
DSM
- CUN
1 stop22h 30m
Frontier
Tue 7/283:31 pm
CUN
- DSM
1 stop22h 03m
Frontier
Deal found 6/29![Frontier logo]()
$414
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/68:00 am
DSM
- GDL
2 stops14h 00m
Multiple Airlines
Fri 9/1810:37 am
GDL
- DSM
1 stop8h 11m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$417
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:06 pm
DSM
- GDL
2 stops31h 59m
Multiple Airlines
Mon 8/2410:25 am
GDL
- DSM
1 stop8h 23m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$428
This Priceline deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/152:19 pm
DSM
- CUN
1 stop22h 30m
Frontier
Tue 7/213:31 pm
CUN
- DSM
1 stop22h 03m
Frontier
Deal found 6/30![Frontier logo]()
$434
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/79:21 pm
DSM
- GDL
2 stops35h 09m
Multiple Airlines
Mon 8/2410:25 am
GDL
- DSM
1 stop8h 23m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$435
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:19 pm
DSM
- MTY
1 stop28h 46m
Multiple Airlines
Wed 8/1911:20 am
MTY
- DSM
1 stop24h 45m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$436
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/42:19 pm
DSM
- GDL
1 stop27h 06m
Multiple Airlines
Fri 9/1810:37 am
GDL
- DSM
1 stop8h 11m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$437
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- GDL
1 stop19h 43m
Multiple Airlines
Sun 8/238:25 am
GDL
- DSM
2 stops34h 23m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$447
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:06 pm
DSM
- GDL
2 stops31h 59m
Multiple Airlines
Sun 8/2311:51 am
GDL
- DSM
1 stop8h 09m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$453
This Priceline deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/312:19 pm
DSM
- CUN
1 stop22h 30m
Frontier
Thu 8/63:31 pm
CUN
- DSM
1 stop22h 03m
Frontier
Deal found 6/30![Frontier logo]()
$454
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:19 pm
DSM
- CUN
1 stop22h 30m
Multiple Airlines
Wed 8/123:06 pm
CUN
- DSM
2 stops32h 13m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$458
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/72:19 pm
DSM
- GDL
1 stop27h 06m
Multiple Airlines
Thu 9/178:22 am
GDL
- DSM
2 stops34h 26m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$459
Best flights from Des Moines to MexicoDiscover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 2, 2026.
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:19 pm
DSM
- MTY
1 stop28h 46m
Multiple Airlines
Wed 8/1911:20 am
MTY
- DSM
1 stop24h 45m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$459
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/32:54 pm
DSM
- CUN
1 stop5h 21m
Delta
Thu 11/128:38 am
CUN
- DSM
2 stops14h 51m
Delta
Deal found 6/28![Delta logo]()
$517
This United Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:35 am
DSM
- SJD
2 stops9h 57m
United Airlines
Tue 11/103:48 pm
SJD
- DSM
1 stop6h 52m
United Airlines
Deal found 7/2![United Airlines logo]()
$542
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:35 am
DSM
- CUN
2 stops7h 40m
Southwest
Wed 11/48:20 am
CUN
- DSM
2 stops13h 25m
Southwest
Deal found 6/30![Southwest logo]()
$573
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:33 am
DSM
- MID
1 stop7h 39m
American Airlines
Fri 8/211:52 pm
MID
- DSM
1 stop18h 09m
American Airlines
Deal found 6/30![American Airlines logo]()
$576
This Aeromexico deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:40 am
DSM
- MEX
2 stops10h 05m
Aeromexico
Thu 8/206:01 am
MEX
- DSM
2 stops10h 49m
Aeromexico
Deal found 6/29![Aeromexico logo]()
$629
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- GDL
1 stop22h 48m
Multiple Airlines
Sun 8/238:25 am
GDL
- DSM
2 stops11h 35m
Multiple Airlines
Deal found 6/27![Multiple Airlines logo]()
$468
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/122:54 pm
DSM
- CUN
1 stop5h 21m
Delta
Fri 10/168:00 am
CUN
- DSM
2 stops12h 51m
Delta
Deal found 6/28![Delta logo]()
$522
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/139:44 pm
DSM
- MTY
2 stops34h 47m
Multiple Airlines
Thu 8/2012:05 pm
MTY
- DSM
1 stop7h 55m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$494
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/155:11 pm
DSM
- PVR
2 stops17h 36m
United Airlines
Wed 11/182:00 pm
PVR
- DSM
1 stop7h 35m
United Airlines
Deal found 6/30![United Airlines logo]()
$546
This Southwest deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:40 am
DSM
- CUN
2 stops7h 50m
Southwest
Thu 8/201:40 pm
CUN
- DSM
2 stops8h 30m
Southwest
Deal found 6/29![Southwest logo]()
$573
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/210:15 am
DSM
- CUN
2 stops9h 55m
Delta
Tue 12/88:00 am
CUN
- DSM
2 stops13h 00m
Delta
Deal found 6/27![Delta logo]()
$522
This American Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/139:32 am
DSM
- MID
1 stop28h 40m
American Airlines
Thu 8/201:52 pm
MID
- DSM
1 stop27h 00m
American Airlines
Deal found 6/29![American Airlines logo]()
$578
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:33 am
DSM
- MLM
1 stop5h 26m
American Airlines
Fri 8/2111:58 am
MLM
- DSM
1 stop26h 14m
American Airlines
Deal found 6/30![American Airlines logo]()
$592
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:00 am
DSM
- PVR
1 stop8h 35m
United Airlines
Wed 12/163:17 pm
PVR
- DSM
1 stop8h 22m
United Airlines
Deal found 6/30![United Airlines logo]()
$599
This Aeromexico deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:54 pm
DSM
- GDL
2 stops19h 37m
Aeromexico
Mon 8/249:33 pm
GDL
- DSM
2 stops24h 04m
Aeromexico
Deal found 7/2![Aeromexico logo]()
$660
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/225:45 am
DSM
- CUN
2 stops12h 54m
Delta
Sat 9/2612:45 pm
CUN
- DSM
1 stop8h 01m
Delta
Deal found 6/27![Delta logo]()
$568
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:32 pm
DSM
- SJD
1 stop16h 19m
American Airlines
Tue 10/131:25 pm
SJD
- DSM
1 stop8h 24m
American Airlines
Deal found 6/27![American Airlines logo]()
$596
This Aeromexico deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:45 am
DSM
- SJD
2 stops14h 48m
Aeromexico
Tue 10/136:17 pm
SJD
- DSM
2 stops21h 25m
Aeromexico
Deal found 6/27![Aeromexico logo]()
$672
This United Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:35 am
DSM
- CUN
2 stops9h 02m
United Airlines
Sat 11/218:39 am
CUN
- DSM
1 stop6h 36m
United Airlines
Deal found 6/27![United Airlines logo]()
$619
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:45 am
DSM
- CUN
1 stop8h 25m
Delta
Wed 9/308:05 am
CUN
- DSM
1 stop10h 04m
Delta
Deal found 6/30![Delta logo]()
$568
This Aeromexico deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:40 am
DSM
- MTY
2 stops28h 10m
Aeromexico
Sat 8/229:03 pm
MTY
- DSM
2 stops24h 34m
Aeromexico
Deal found 7/1![Aeromexico logo]()
$673
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/164:28 pm
DSM
- MLM
1 stop19h 31m
American Airlines
Sun 8/2311:58 am
MLM
- DSM
1 stop20h 03m
American Airlines
Deal found 7/2![American Airlines logo]()
$621
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:55 am
DSM
- CUN
1 stop6h 01m
Delta
Wed 8/198:05 am
CUN
- DSM
2 stops12h 34m
Delta
Deal found 6/30![Delta logo]()
$573
This United Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:00 am
DSM
- MEX
2 stops10h 50m
United Airlines
Wed 8/266:30 am
MEX
- DSM
1 stop6h 44m
United Airlines
Deal found 7/2![United Airlines logo]()
$633
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:35 pm
DSM
- PVR
2 stops19h 28m
American Airlines
Thu 8/202:58 pm
PVR
- DSM
2 stops17h 03m
American Airlines
Deal found 7/1![American Airlines logo]()
$622
This Delta deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:25 am
DSM
- CUN
2 stops12h 45m
Delta
Sat 11/218:00 am
CUN
- DSM
2 stops13h 52m
Delta
Deal found 6/27![Delta logo]()
$573
This Aeromexico deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/132:54 pm
DSM
- MTY
2 stops18h 03m
Aeromexico
Thu 8/207:45 pm
MTY
- DSM
2 stops25h 52m
Aeromexico
Deal found 6/29![Aeromexico logo]()
$694
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:00 am
DSM
- MEX
1 stop7h 45m
United Airlines
Mon 8/102:10 pm
MEX
- DSM
1 stop7h 46m
United Airlines
Deal found 7/1![United Airlines logo]()
$636
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:22 pm
DSM
- PVR
1 stop18h 56m
American Airlines
Sat 10/103:53 pm
PVR
- DSM
1 stop6h 14m
American Airlines
Deal found 7/1![American Airlines logo]()
$627
Last-minute flights from Des Moines to MexicoDiscover last-minute flight deals from Des Moines to Mexico. Data last updated July 2, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mexico. Data last updated July 2, 2026 and is based on user searches.
This Priceline deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/152:19 pm
DSM
- CUN
1 stop22h 30m
Frontier
Tue 7/213:31 pm
CUN
- DSM
1 stop22h 03m
Frontier
Deal found 6/30![Frontier logo]()
$434
This Priceline deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/222:19 pm
DSM
- CUN
1 stop22h 30m
Frontier
Tue 7/283:31 pm
CUN
- DSM
1 stop22h 03m
Frontier
Deal found 6/29![Frontier logo]()
$414
This Priceline deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/312:19 pm
DSM
- CUN
1 stop22h 30m
Frontier
Thu 8/63:31 pm
CUN
- DSM
1 stop22h 03m
Frontier
Deal found 6/30![Frontier logo]()
$454
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:19 pm
DSM
- CUN
1 stop22h 30m
Multiple Airlines
Wed 8/123:06 pm
CUN
- DSM
2 stops32h 13m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$458
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/79:21 pm
DSM
- GDL
2 stops35h 09m
Multiple Airlines
Mon 8/2410:25 am
GDL
- DSM
1 stop8h 23m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$435
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/79:21 pm
DSM
- GDL
2 stops35h 09m
Multiple Airlines
Sun 8/2311:51 am
GDL
- DSM
1 stop8h 09m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$460
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:06 pm
DSM
- GDL
2 stops31h 59m
Multiple Airlines
Mon 8/2410:25 am
GDL
- DSM
1 stop8h 23m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$428
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:06 pm
DSM
- GDL
2 stops31h 59m
Multiple Airlines
Sun 8/2311:51 am
GDL
- DSM
1 stop8h 09m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$453
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:19 pm
DSM
- MTY
1 stop28h 46m
Multiple Airlines
Wed 8/1911:20 am
MTY
- DSM
1 stop24h 45m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$436
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:19 pm
DSM
- GDL
1 stop27h 06m
Multiple Airlines
Mon 8/2410:25 am
GDL
- DSM
1 stop8h 23m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$470
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:19 pm
DSM
- MEX
1 stop28h 11m
Multiple Airlines
Wed 8/198:45 am
MEX
- DSM
2 stops27h 20m
Multiple Airlines
Deal found 6/27![Multiple Airlines logo]()
$480
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- GDL
1 stop19h 43m
Multiple Airlines
Sun 8/238:25 am
GDL
- DSM
2 stops34h 23m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$447
One-way flights from Des Moines to MexicoSearch for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated July 2, 2026.
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated July 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/212:31 pm
DSM
- MTY
2 stops33h 04m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$175
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/191:47 pm
DSM
- MTY
1 stop30h 33m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$183
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2410:01 pm
DSM
- GDL
2 stops34h 29m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/183:39 pm
DSM
- MTY
1 stop24h 26m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$192
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:42 pm
DSM
- MEX
1 stop32h 03m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1611:47 am
DSM
- MTY
1 stop8h 33m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/312:19 pm
DSM
- CUN
1 stop22h 30m
Frontier
Deal found 6/30![Frontier logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:31 pm
DSM
- CUN
2 stops33h 27m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/223:54 pm
DSM
- MTY
1 stop28h 26m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/292:19 pm
DSM
- GDL
1 stop27h 06m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/222:19 pm
DSM
- GDL
1 stop27h 06m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1310:01 pm
DSM
- MLM
2 stops42h 04m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$218
Find flight deals from Des Moines to Mexico
Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated July 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $414 (Priceline) |
One-way from | $175 (Kiwi.com) |
Popular in | December |
Cheapest in | March |
Average price | $690 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2026.
Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMonterrey
DSM - MTY
DSMMTY
Des Moines
Wed 8/12
2:19 pm-6:05 pm
1 stop28h 46m
Monterrey Gen Mariano Escobedo
Wed 8/19
11:20 am-1:05 pm
1 stop24h 45m
$459
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Mon 8/17
10:06 pm-7:54 pm
1 stop22h 48m
Guadalajara Miguel Hidal
Sun 8/23
8:25 am-9:00 pm
2 stops11h 35m
$468
Des MoinesMonterrey
DSM - MTY
DSMMTY
Des Moines
Thu 8/13
9:44 pm-7:31 am
2 stops34h 47m
Monterrey Gen Mariano Escobedo
Thu 8/20
12:05 pm-9:00 pm
1 stop7h 55m
$494
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Tue 11/3
2:54 pm-9:15 pm
1 stop5h 21m
Cancun
Thu 11/12
8:38 am-10:29 pm
2 stops14h 51m
$517
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Mon 10/12
2:54 pm-8:15 pm
1 stop5h 21m
Cancun
Fri 10/16
8:00 am-8:51 pm
2 stops12h 51m
$522
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Wed 12/2
10:15 am-9:10 pm
2 stops9h 55m
Cancun
Tue 12/8
8:00 am-8:00 pm
2 stops13h 00m
$522
Des MoinesSan José del Cabo
DSM - SJD
DSMSJD
Des Moines
Tue 11/3
5:35 am-2:32 pm
2 stops9h 57m
San José del Cabo Los Cabos
Tue 11/10
3:48 pm-11:40 pm
1 stop6h 52m
$542
Des MoinesPuerto Vallarta
DSM - PVR
DSMPVR
Des Moines
Sun 11/15
5:11 pm-10:47 am
2 stops17h 36m
Puerto Vallarta Ordaz
Wed 11/18
2:00 pm-9:35 pm
1 stop7h 35m
$546
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Tue 9/22
5:45 am-6:39 pm
2 stops12h 54m
Cancun
Sat 9/26
12:45 pm-8:46 pm
1 stop8h 01m
$568
Des MoinesCancún
DSM - CUN
DSMCUN
Des Moines
Fri 9/25
5:45 am-2:10 pm
1 stop8h 25m
Cancun
Wed 9/30
8:05 am-6:09 pm
1 stop10h 04m
$568
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mexico
Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.
DSM-CUN
DSM-GDL
DSM-SJD
DSM-PVR
DSM-BJX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mexico
DSM-MX0
DSM-CUN
DSM-GDL
DSM-SJD
DSM-PVR
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, June is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $206). Flying from Des Moines to Mexico in May is currently the most expensive (average of $450). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How far ahead should I book a flight from Des Moines to Mexico?
Booking 19 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Mexico. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Reviews of airlines servicing Mexico
Get insights into the airlines that provide service to Mexico. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mexico. Reviews last updated July 2, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to Mexico have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Overall
7.9
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Overall
7.9
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Overall
7.9
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Overall
7.9
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Overall
7.9
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mexico
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Complete your trip
Complete your trip to Mexico by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Mexico, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Mexico flights
Browse other Des Moines and Mexico flight options. Last updated on July 2, 2026.
Popular flight searches
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Des Moines to Mexico flights
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Consider these flights traveling to Mexico regions.
Top 5 airlines flying from Des Moines to Mexico
Discover the top 5 airlines that operate flights from Des Moines to Mexico. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$276 | Average$494 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$379 | Average$673 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$398 | Average$652 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$411 | Average$695 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$569 | Average$788 | FlexibilityNo cancel fee | On-time63% |