What are the cheapest airlines flying from Des Moines to Guadalajara round-trip?

According to our current data, American Airlines ($544), United Airlines ($564), and Delta ($629) offers the cheapest pricing from Des Moines to Guadalajara. Users have found that American Airlines is 16% cheaper than the other options available to this destination.

What are the cheapest airlines to fly from Des Moines to Guadalajara one-way?

To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $293. Delta flights start at $353 while deals on United Airlines start at $358 one-way.

What is the cheapest day to fly from Des Moines to Guadalajara?

Travelers seeking maximum savings on their Des Moines to Guadalajara flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Friday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Guadalajara ranges from 0.0 - 9.4 inches per month. July is typically the wettest month, when rainfall can reach 9.4 in. February is typically the driest time to visit Guadalajara when rainfall is around 0.0 in.

If weather is an important factor for your trip to Guadalajara, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 59.0 F).

What is the cheapest day to fly round-trip from Des Moines to Guadalajara?

Friday is generally a great day to depart. Flying on this day could help you save up to 34%.

What is the cheapest month to fly from Des Moines to Guadalajara?

Flights from Des Moines to Guadalajara lean towards being more expensive in December. Prices are generally better when you fly from Des Moines to Guadalajara in September, with the cheapest ticket starting at $502.

What is the cheapest time of day to fly from DSM to GDL?

It’s typically best to fly out from Des Moines to Guadalajara in the morning. Doing so could potentially save you 28% on the flight price compared to flying in the afternoon, which is usually more expensive.

Can I find deals for flights from Des Moines to Guadalajara that include hotel bookings?

Yes. In addition to deals on Des Moines to Guadalajara flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Guadalajara?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Guadalajara.

Can I find deals for business class flights from Des Moines to Guadalajara?

Yes. Cheapflights offers flight deals from Des Moines to Guadalajara by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$172+ Flights from Des Moines to Guadalajara

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Cheap flight deals from Des Moines to Guadalajara

Round-trip from	$367 (Mytrip)
One-way from	$172 (Mytrip)
Popular in	December
Cheapest in	September
Average price	$623

From Des Moines to Guadalajara Miguel Hidal

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One-way flight from Des Moines to Guadalajara Miguel Hidal

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Highest demand for flights based on searches. 12% potential increase in price ($93 potential increase over avg. RT price).

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Cheapest flight prices on average. 4% potential price decrease ($30 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Des Moines to Guadalajara

Cheapest flights from Des Moines to Guadalajara
Explore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

Sun 8/174:00 pmDSM - GDL

2 stops22h 14mMultiple Airlines

Sun 8/249:05 pmGDL - DSM

2 stops24h 37mMultiple Airlines

Deal found 7/3

$367

Mon 7/287:22 pmDSM - GDL

1 stop15h 28mAmerican Airlines

Tue 8/121:28 pmGDL - DSM

1 stop9h 46mAmerican Airlines

Deal found 7/2

$544

Thu 10/26:15 amDSM - GDL

1 stop6h 10mUnited Airlines

Sun 10/512:30 pmGDL - DSM

1 stop8h 58mUnited Airlines

Deal found 7/2

$564

Fri 8/157:00 amDSM - GDL

2 stops11h 58mDelta

Fri 8/229:17 amGDL - DSM

2 stops12h 22mDelta

Deal found 7/2

$629

Best flights from Des Moines to Guadalajara
Discover carefully curated flight deals from Des Moines to Guadalajara that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 3, 2025.

Sun 8/174:00 pmDSM - GDL

2 stops22h 14mMultiple Airlines

Sun 8/249:05 pmGDL - DSM

2 stops24h 37mMultiple Airlines

Deal found 7/3

$367

Mon 7/287:22 pmDSM - GDL

1 stop15h 28mAmerican Airlines

Tue 8/121:28 pmGDL - DSM

1 stop9h 46mAmerican Airlines

Deal found 7/2

$544

Thu 10/26:15 amDSM - GDL

1 stop6h 10mUnited Airlines

Sun 10/512:30 pmGDL - DSM

1 stop8h 58mUnited Airlines

Deal found 7/2

$564

Fri 8/157:00 amDSM - GDL

2 stops11h 58mDelta

Fri 8/229:17 amGDL - DSM

2 stops12h 22mDelta

Deal found 7/2

$629

Last-minute flights from Des Moines to Guadalajara
Discover last-minute flight deals from Des Moines to Guadalajara. Data last updated July 3, 2025 and is based on user searches.

Thu 7/105:35 amDSM - GDL

1 stop8h 15mAmerican Airlines

Fri 7/181:30 pmGDL - DSM

1 stop9h 29mAmerican Airlines

Deal found 7/1

$724

Thu 7/1011:24 amDSM - GDL

2 stops13h 19mDelta

Fri 7/187:24 amGDL - DSM

2 stops14h 09mDelta

Deal found 7/1

$769

Fri 7/111:15 pmDSM - GDL

1 stop8h 05mMultiple Airlines

Sun 7/276:00 amGDL - DSM

2 stops10h 42mMultiple Airlines

Deal found 6/30

$575

Fri 7/117:33 pmDSM - GDL

2 stops21h 32mFrontier

Sun 7/279:05 pmGDL - DSM

2 stops20h 43mFrontier

Deal found 6/30

$735

Mon 7/287:22 pmDSM - GDL

1 stop15h 28mAmerican Airlines

Tue 8/121:28 pmGDL - DSM

1 stop9h 46mAmerican Airlines

Deal found 7/2

$544

Fri 8/157:00 amDSM - GDL

2 stops11h 58mDelta

Fri 8/229:17 amGDL - DSM

2 stops12h 22mDelta

Deal found 7/2

$629

Sat 8/166:02 amDSM - GDL

1 stop8h 32mUnited Airlines

Sat 8/2312:30 pmGDL - DSM

1 stop8h 58mUnited Airlines

Deal found 7/2

$579

Sun 8/174:00 pmDSM - GDL

2 stops22h 14mMultiple Airlines

Sun 8/249:05 pmGDL - DSM

2 stops24h 37mMultiple Airlines

Deal found 7/3

$367

One-way flights from Des Moines to Guadalajara
Search for one-way flight options from Des Moines to Guadalajara. Find affordable one-way fares based on user searches. Data last updated July 3, 2025.

Sun 8/174:00 pmDSM - GDL

2 stops22h 14mMultiple Airlines

Deal found 7/2

$172

Wed 8/66:13 pmDSM - GDL

2 stops19h 35mAmerican Airlines

Deal found 7/2

$293

Thu 7/175:30 amDSM - GDL

2 stops13h 17mDelta

Deal found 7/3

$353

Fri 9/196:15 amDSM - GDL

1 stop6h 10mUnited Airlines

Deal found 7/2

$358

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Guadalajara that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Sun 8/17

4:00 pm-1:14 pm

2 stops22h 14m

Guadalajara Miguel Hidal

Sun 8/24

9:05 pm-10:42 pm

2 stops24h 37m

$367

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Mon 7/28

7:22 pm-9:50 am

1 stop15h 28m

Guadalajara Miguel Hidal

Tue 8/12

1:28 pm-12:14 am

1 stop9h 46m

$544

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Thu 10/2

6:15 am-11:25 am

1 stop6h 10m

Guadalajara Miguel Hidal

Sun 10/5

12:30 pm-10:28 pm

1 stop8h 58m

$564

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Fri 8/15

7:00 am-5:58 pm

2 stops11h 58m

Guadalajara Miguel Hidal

Fri 8/22

9:17 am-10:39 pm

2 stops12h 22m

$629

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Sun 8/17

4:00 pm-1:14 pm

2 stops22h 14m

$172

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Wed 8/6

6:13 pm-12:48 pm

2 stops19h 35m

$293

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Sun 8/17

6:50 pm-9:34 pm

2 stops27h 44m

$344

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

Thu 7/17

5:30 am-5:47 pm

2 stops13h 17m

$353

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/2

Best time to book a flight from Des Moines to Guadalajara

Have a flexible travel schedule? Discover the best time to fly to Guadalajara from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Guadalajara

What is the cheapest month to book a flight from Des Moines to Guadalajara?

Currently, February is the cheapest month in which you can book a flight from Des Moines to Guadalajara (average of $265). Flying from Des Moines to Guadalajara in December is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Guadalajara?

Reviews of airlines servicing Guadalajara

Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Guadalajara to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,982 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,982 reviews

Delta

8.0

Very good

7,982 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,861 reviews

Delta

8.0

Very good

7,982 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,982 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from Des Moines to Guadalajara round-trip?
According to our current data, American Airlines ($544), United Airlines ($564), and Delta ($629) offers the cheapest pricing from Des Moines to Guadalajara. Users have found that American Airlines is 16% cheaper than the other options available to this destination.
What are the cheapest airlines to fly from Des Moines to Guadalajara one-way?
To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $293. Delta flights start at $353 while deals on United Airlines start at $358 one-way.
Can I find deals for flights from Des Moines to Guadalajara that include hotel bookings?
Yes. In addition to deals on Des Moines to Guadalajara flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Guadalajara?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Guadalajara.
Can I find deals for business class flights from Des Moines to Guadalajara?
Yes. Cheapflights offers flight deals from Des Moines to Guadalajara by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Guadalajara?
Currently, February is the cheapest month in which you can book a flight from Des Moines to Guadalajara (average of $265). Flying from Des Moines to Guadalajara in December is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Other flights to Guadalajara

Top 2 airlines flying from Des Moines to Guadalajara

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$502	Average$622	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$521	Average$715	FlexibilityNo cancel fee	On-time69%

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$172+ Cheap flights from Des Moines (DSM) to Guadalajara (GDL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/17. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Guadalajara with Cheapflights

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2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to Guadalajara

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to Guadalajara

Cheapest flights from Des Moines to GuadalajaraExplore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

Explore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Guadalajara that are best for you.

Best time to book a flight from Des Moines to Guadalajara

Have a flexible travel schedule? Discover the best time to fly to Guadalajara from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Guadalajara

What is the cheapest month to book a flight from Des Moines to Guadalajara?

How much does it cost to fly round-trip from Des Moines to Guadalajara?

Reviews of airlines servicing Guadalajara

Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Guadalajara to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Guadalajara. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Des Moines to Guadalajara round-trip?

What are the cheapest airlines to fly from Des Moines to Guadalajara one-way?

Can I find deals for flights from Des Moines to Guadalajara that include hotel bookings?

How can I find direct flights from Des Moines to Guadalajara?

Can I find deals for business class flights from Des Moines to Guadalajara?

What is the cheapest month to book a flight from Des Moines to Guadalajara?

Traveling to a place near Des Moines?

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Alternative routes for Des Moines to Guadalajara

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Top 2 airlines flying from Des Moines to Guadalajara

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Cheapest flights from Des Moines to Guadalajara
Explore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.