$279+ Cheap flights from Des Moines (DSM) to Guadalajara (GDL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/7. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GDL
May 11 — May 181
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Guadalajara with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Guadalajara
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Cheapest flights from Des Moines to GuadalajaraExplore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2026.
Explore the most affordable flight options available from Des Moines to Guadalajara. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/122:16 pm
DSM
- GDL
1 stop11h 16m
Multiple Airlines
Tue 6/168:46 am
GDL
- DSM
2 stops27h 45m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$446
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- GDL
1 stop22h 38m
Multiple Airlines
Fri 5/155:00 pm
GDL
- DSM
2 stops48h 01m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$533
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/911:00 am
DSM
- GDL
1 stop31h 24m
Multiple Airlines
Mon 5/1811:00 am
GDL
- DSM
2 stops48h 59m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$545
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/113:37 pm
DSM
- GDL
2 stops26h 31m
Multiple Airlines
Mon 6/158:46 am
GDL
- DSM
1 stop11h 20m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$589
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/279:30 am
DSM
- GDL
2 stops33h 50m
Multiple Airlines
Sun 7/510:25 am
GDL
- DSM
1 stop9h 18m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$591
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
- GDL
2 stops18h 57m
Multiple Airlines
Fri 5/88:45 am
GDL
- DSM
1 stop11h 26m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$595
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1710:14 pm
DSM
- GDL
1 stop22h 38m
Multiple Airlines
Sun 4/267:59 am
GDL
- DSM
1 stop28h 10m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$596
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/218:00 am
DSM
- GDL
2 stops12h 52m
Multiple Airlines
Thu 5/2811:50 am
GDL
- DSM
1 stop7h 54m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$601
This Priceline deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:04 pm
DSM
- GDL
2 stops30h 48m
Frontier
Sun 4/267:13 am
GDL
- DSM
2 stops28h 56m
Frontier
Deal found 4/8![Frontier logo]()
$608
Best flights from Des Moines to GuadalajaraDiscover carefully curated flight deals from Des Moines to Guadalajara that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 11, 2026.
Discover carefully curated flight deals from Des Moines to Guadalajara that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 11, 2026.
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:05 am
DSM
- GDL
2 stops11h 45m
Delta
Fri 7/176:00 pm
GDL
- DSM
2 stops14h 45m
Delta
Deal found 4/8![Delta logo]()
$677
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2912:06 pm
DSM
- GDL
1 stop11h 53m
American Airlines
Wed 5/61:29 pm
GDL
- DSM
1 stop9h 30m
American Airlines
Deal found 4/8![American Airlines logo]()
$677
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2911:51 am
DSM
- GDL
2 stops12h 33m
Delta
Wed 5/67:42 am
GDL
- DSM
2 stops13h 52m
Delta
Deal found 4/6![Delta logo]()
$682
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:05 am
DSM
- GDL
2 stops11h 45m
Delta
Thu 8/136:00 pm
GDL
- DSM
2 stops15h 15m
Delta
Deal found 4/8![Delta logo]()
$717
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:27 am
DSM
- GDL
2 stops13h 00m
Delta
Sun 5/319:11 am
GDL
- DSM
2 stops12h 21m
Delta
Deal found 4/10![Delta logo]()
$717
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:45 am
DSM
- GDL
2 stops12h 02m
Delta
Fri 5/89:26 am
GDL
- DSM
2 stops12h 06m
Delta
Deal found 4/7![Delta logo]()
$732
Last-minute flights from Des Moines to GuadalajaraDiscover last-minute flight deals from Des Moines to Guadalajara. Data last updated April 11, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Guadalajara. Data last updated April 11, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1710:14 pm
DSM
- GDL
1 stop22h 38m
Multiple Airlines
Sun 4/267:59 am
GDL
- DSM
1 stop28h 10m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$596
This Priceline deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:04 pm
DSM
- GDL
2 stops30h 48m
Frontier
Sun 4/267:13 am
GDL
- DSM
2 stops28h 56m
Frontier
Deal found 4/8![Frontier logo]()
$608
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1710:14 pm
DSM
- GDL
1 stop22h 38m
Multiple Airlines
Mon 4/277:56 pm
GDL
- DSM
2 stops44h 12m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$613
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2912:06 pm
DSM
- GDL
1 stop11h 53m
American Airlines
Wed 5/61:29 pm
GDL
- DSM
1 stop9h 30m
American Airlines
Deal found 4/6![American Airlines logo]()
$657
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:14 pm
DSM
- GDL
1 stop22h 38m
Multiple Airlines
Fri 5/155:00 pm
GDL
- DSM
2 stops48h 01m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$533
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
- GDL
2 stops18h 57m
Multiple Airlines
Fri 5/88:45 am
GDL
- DSM
1 stop11h 26m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$595
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/911:00 am
DSM
- GDL
1 stop31h 24m
Multiple Airlines
Mon 5/1811:00 am
GDL
- DSM
2 stops48h 59m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$545
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:15 am
DSM
- GDL
1 stop6h 19m
United Airlines
Mon 5/182:30 pm
GDL
- DSM
1 stop7h 15m
United Airlines
Deal found 4/9![United Airlines logo]()
$672
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/218:00 am
DSM
- GDL
2 stops12h 52m
Multiple Airlines
Thu 5/2811:50 am
GDL
- DSM
1 stop7h 54m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$601
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:01 am
DSM
- GDL
2 stops10h 46m
Delta
Wed 6/38:28 am
GDL
- DSM
2 stops13h 04m
Delta
Deal found 4/8![Delta logo]()
$652
One-way flights from Des Moines to GuadalajaraSearch for one-way flight options from Des Moines to Guadalajara. Find affordable one-way fares based on user searches. Data last updated April 11, 2026.
Search for one-way flight options from Des Moines to Guadalajara. Find affordable one-way fares based on user searches. Data last updated April 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:00 am
DSM
- GDL
3 stops55h 34m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$279
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:06 pm
DSM
- GDL
1 stop11h 57m
American Airlines
Deal found 4/7![American Airlines logo]()
$360
This Aeromexico deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:27 am
DSM
- GDL
2 stops29h 32m
Aeromexico
Deal found 4/9![Aeromexico logo]()
$384
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/304:48 pm
DSM
- GDL
1 stop6h 26m
American Airlines
Deal found 4/9![American Airlines logo]()
$393
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/911:23 am
DSM
- GDL
2 stops11h 11m
United Airlines
Deal found 4/10![United Airlines logo]()
$414
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:00 am
DSM
- GDL
3 stops30h 25m
United Airlines
Deal found 4/9![United Airlines logo]()
$485
Find flight deals from Des Moines to Guadalajara
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Guadalajara (GDL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $446 (Kiwi.com) |
One-way from | $211 (Kiwi.com) |
Popular in | September |
Cheapest in | May |
Average price | $724 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Guadalajara that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 11, 2026.
Use the filters below to find and compare flights from Des Moines to Guadalajara that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Wed 7/8
7:05 am-5:50 pm
2 stops11h 45m
Guadalajara Miguel Hidal
Fri 7/17
6:00 pm-9:45 am
2 stops14h 45m
$677
Quickest round-trip
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Wed 4/29
12:06 pm-10:59 pm
1 stop11h 53m
Guadalajara Miguel Hidal
Wed 5/6
1:29 pm-11:59 pm
1 stop9h 30m
$677
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Wed 4/29
11:51 am-11:24 pm
2 stops12h 33m
Guadalajara Miguel Hidal
Wed 5/6
7:42 am-10:34 pm
2 stops13h 52m
$682
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Thu 8/6
7:05 am-5:50 pm
2 stops11h 45m
Guadalajara Miguel Hidal
Thu 8/13
6:00 pm-10:15 am
2 stops15h 15m
$717
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Sat 5/16
5:27 am-5:27 pm
2 stops13h 00m
Guadalajara Miguel Hidal
Sun 5/31
9:11 am-10:32 pm
2 stops12h 21m
$717
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Mon 5/4
5:45 am-4:47 pm
2 stops12h 02m
Guadalajara Miguel Hidal
Fri 5/8
9:26 am-10:32 pm
2 stops12h 06m
$732
Cheapest one-way
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Thu 5/7
7:00 am-1:34 pm
3 stops55h 34m
$279
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Sat 5/30
5:27 am-9:59 am
2 stops29h 32m
$384
Quickest one-way
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Sat 5/30
4:48 pm-10:14 pm
1 stop6h 26m
$393
Des MoinesGuadalajara
DSM - GDL
DSMGDL
Des Moines
Tue 6/9
3:01 pm-9:34 pm
1 stop7h 33m
$414
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Guadalajara
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Guadalajara in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Guadalajara flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Guadalajara flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Guadalajara flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Guadalajara flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Guadalajara flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Guadalajara
Have a flexible travel schedule? Discover the best time to fly to Guadalajara from Des Moines with our price prediction graph.
DSM-GDL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Guadalajara
What is the cheapest month to book a flight from Des Moines to Guadalajara?
Currently, April is the cheapest month in which you can book a flight from Des Moines to Guadalajara (average of $360). Flying from Des Moines to Guadalajara in March is currently the most expensive (average of $831). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Guadalajara?
Reviews of airlines servicing Guadalajara
Get insights into the airlines that provide service to Guadalajara. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guadalajara. Reviews last updated April 11, 2026.
Peruse reviews from past customers who have flown with United Airlines and American Airlines from Des Moines to Guadalajara to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.3
Entertainment
7.1
Food
6.6
Crew
8.1
Boarding
7.7
Overall
7.4
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Comfort
7.3
Entertainment
7.1
Food
6.6
Crew
8.1
Boarding
7.7
Overall
7.4
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Comfort
7.3
Entertainment
7.1
Food
6.6
Crew
8.1
Boarding
7.7
Overall
7.4
Reviews
1 / 20
10.0
ExcellentDane,Jan 2026
TYS - IAD
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Guadalajara. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Guadalajara?
Book flights to Guadalajara if you plan to visit one of these locationsTlaquepaque
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Other flights to Guadalajara
Explore flights to Guadalajara departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 11, 2026.
Des Moines and Guadalajara flights
Browse other Des Moines and Guadalajara flight options. Last updated on April 11, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on April 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Des Moines to Guadalajara
Discover the top 2 airlines that operate flights from Des Moines to Guadalajara. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$536 | Average$651 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$563 | Average$724 | FlexibilityNo cancel fee | On-time69% |