$201+ Cheap flights from Missouri to Panama City (PTY)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
May 10 — May 171
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Panama City
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Cheapest flights from Missouri to Panama CityExplore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 10, 2026.
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 10, 2026.
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:16 am
MCI
- PTY
1 stop12h 21m
United Airlines
Tue 8/113:30 pm
PTY
- MCI
2 stops18h 51m
United Airlines
Deal found 4/6![United Airlines logo]()
$471
This KAYAK deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
MCI
- PTY
1 stop13h 31m
Copa Airlines
Tue 6/210:00 am
PTY
- MCI
1 stop12h 31m
Copa Airlines
Deal found 4/6![Copa Airlines logo]()
$479
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:30 am
MCI
- PTY
1 stop10h 07m
United Airlines
Thu 8/2010:55 pm
PTY
- MCI
2 stops19h 47m
United Airlines
Deal found 4/6![United Airlines logo]()
$491
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/78:30 am
MCI
- PTY
1 stop29h 44m
United Airlines
Wed 6/103:30 pm
PTY
- MCI
1 stop18h 33m
United Airlines
Deal found 4/7![United Airlines logo]()
$496
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:08 am
MCI
- PTY
1 stop9h 12m
American Airlines
Tue 9/13:20 pm
PTY
- MCI
1 stop9h 09m
American Airlines
Deal found 4/4![American Airlines logo]()
$501
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:14 am
STL
- PTY
1 stop8h 23m
United Airlines
Mon 5/1810:00 am
PTY
- STL
1 stop12h 30m
United Airlines
Deal found 4/4![United Airlines logo]()
$505
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:00 am
MCI
- PTY
2 stops22h 04m
United Airlines
Mon 8/1010:55 pm
PTY
- MCI
2 stops15h 22m
United Airlines
Deal found 4/5![United Airlines logo]()
$505
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:30 am
STL
- PTY
2 stops12h 07m
United Airlines
Tue 6/23:30 pm
PTY
- STL
2 stops20h 41m
United Airlines
Deal found 4/4![United Airlines logo]()
$509
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:50 pm
STL
- PTY
1 stop18h 12m
Delta
Tue 5/192:15 pm
PTY
- STL
1 stop9h 44m
Delta
Deal found 4/4![Delta logo]()
$513
This KAYAK deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:00 am
MCI
- PTY
1 stop13h 31m
Copa Airlines
Mon 8/103:30 pm
PTY
- MCI
1 stop18h 35m
Copa Airlines
Deal found 4/4![Copa Airlines logo]()
$513
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:55 pm
MCI
- PTY
2 stops17h 50m
United Airlines
Sat 10/313:41 pm
PTY
- MCI
1 stop31h 26m
United Airlines
Deal found 4/5![United Airlines logo]()
$515
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
STL
- PTY
2 stops13h 31m
United Airlines
Mon 6/13:30 pm
PTY
- STL
1 stop26h 12m
United Airlines
Deal found 4/6![United Airlines logo]()
$518
Best flights from Missouri to Panama CityDiscover carefully curated flight deals from Missouri to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 10, 2026.
Discover carefully curated flight deals from Missouri to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 10, 2026.
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:23 am
MCI
- PTY
1 stop7h 51m
United Airlines
Thu 8/2010:55 pm
PTY
- MCI
2 stops19h 47m
United Airlines
Deal found 4/5![United Airlines logo]()
$471
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:00 am
STL
- PTY
1 stop7h 02m
Delta
Wed 5/132:15 pm
PTY
- STL
1 stop9h 44m
Delta
Deal found 4/6![Delta logo]()
$505
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/66:12 pm
SGF
- PTY
2 stops18h 02m
American Airlines
Sat 7/111:14 pm
PTY
- SGF
2 stops20h 43m
American Airlines
Deal found 4/5![American Airlines logo]()
$852
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/78:30 am
MCI
- PTY
1 stop29h 44m
United Airlines
Wed 6/103:30 pm
PTY
- MCI
1 stop18h 33m
United Airlines
Deal found 4/7![United Airlines logo]()
$496
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:00 am
STL
- PTY
1 stop10h 12m
United Airlines
Wed 5/2010:00 am
PTY
- STL
1 stop12h 30m
United Airlines
Deal found 4/4![United Airlines logo]()
$505
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:00 am
STL
- PTY
1 stop6h 50m
Delta
Mon 6/12:15 pm
PTY
- STL
1 stop7h 23m
Delta
Deal found 4/4![Delta logo]()
$576
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:00 am
MCI
- PTY
2 stops22h 04m
United Airlines
Mon 8/103:30 pm
PTY
- MCI
2 stops17h 37m
United Airlines
Deal found 4/4![United Airlines logo]()
$505
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:00 am
STL
- PTY
1 stop6h 50m
Delta
Tue 5/262:15 pm
PTY
- STL
1 stop7h 23m
Delta
Deal found 4/5![Delta logo]()
$588
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:36 pm
MCI
- PTY
2 stops21h 36m
United Airlines
Tue 6/93:30 pm
PTY
- MCI
1 stop18h 33m
United Airlines
Deal found 4/4![United Airlines logo]()
$505
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/76:00 am
STL
- PTY
1 stop7h 09m
Delta
Wed 6/102:24 pm
PTY
- STL
1 stop9h 32m
Delta
Deal found 4/7![Delta logo]()
$588
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:00 am
STL
- PTY
1 stop12h 37m
United Airlines
Sun 5/177:55 am
PTY
- STL
1 stop14h 35m
United Airlines
Deal found 4/5![United Airlines logo]()
$522
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/258:15 pm
STL
- PTY
2 stops23h 16m
United Airlines
Thu 5/2810:00 am
PTY
- STL
1 stop10h 42m
United Airlines
Deal found 4/5![United Airlines logo]()
$552
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/76:00 am
STL
- PTY
2 stops22h 04m
United Airlines
Wed 6/103:30 pm
PTY
- STL
2 stops20h 41m
United Airlines
Deal found 4/7![United Airlines logo]()
$594
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:15 am
SGF
- PTY
1 stop12h 22m
United Airlines
Thu 5/2810:00 am
PTY
- SGF
1 stop9h 08m
United Airlines
Deal found 4/6![United Airlines logo]()
$659
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/66:15 am
SGF
- PTY
1 stop12h 22m
United Airlines
Sat 7/117:55 am
PTY
- SGF
1 stop10h 48m
United Airlines
Deal found 4/5![United Airlines logo]()
$688
Last-minute flights from Missouri to Panama CityDiscover last-minute flight deals from Missouri to Panama City. Data last updated April 10, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Panama City. Data last updated April 10, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:50 pm
STL
- PTY
1 stop18h 12m
Delta
Thu 5/212:15 pm
PTY
- STL
1 stop9h 44m
Delta
Deal found 4/4![Delta logo]()
$513
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:14 am
STL
- PTY
1 stop8h 23m
United Airlines
Mon 5/1810:00 am
PTY
- STL
1 stop12h 30m
United Airlines
Deal found 4/4![United Airlines logo]()
$505
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/102:59 pm
MCI
- PTY
1 stop23h 15m
United Airlines
Wed 5/207:55 am
PTY
- MCI
1 stop14h 34m
United Airlines
Deal found 4/5![United Airlines logo]()
$526
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/138:30 pm
STL
- PTY
2 stops19h 42m
United Airlines
Wed 5/277:55 am
PTY
- STL
2 stops13h 21m
United Airlines
Deal found 4/4![United Airlines logo]()
$509
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/148:30 pm
STL
- PTY
2 stops17h 44m
United Airlines
Mon 6/13:30 pm
PTY
- STL
2 stops17h 11m
United Airlines
Deal found 4/4![United Airlines logo]()
$526
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:00 am
STL
- PTY
1 stop6h 50m
Delta
Tue 5/262:15 pm
PTY
- STL
1 stop9h 44m
Delta
Deal found 4/4![Delta logo]()
$522
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:00 am
STL
- PTY
1 stop6h 50m
Delta
Mon 6/12:15 pm
PTY
- STL
1 stop7h 23m
Delta
Deal found 4/8![Delta logo]()
$525
This KAYAK deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
MCI
- PTY
1 stop13h 31m
Copa Airlines
Tue 6/210:00 am
PTY
- MCI
1 stop12h 31m
Copa Airlines
Deal found 4/6![Copa Airlines logo]()
$479
This KAYAK deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
MCI
- PTY
1 stop13h 31m
Copa Airlines
Mon 6/13:30 pm
PTY
- MCI
2 stops17h 37m
Copa Airlines
Deal found 4/6![Copa Airlines logo]()
$483
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:55 pm
MCI
- PTY
2 stops23h 36m
United Airlines
Mon 6/13:30 pm
PTY
- MCI
2 stops17h 37m
United Airlines
Deal found 4/6![United Airlines logo]()
$505
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
STL
- PTY
2 stops13h 31m
United Airlines
Mon 6/13:30 pm
PTY
- STL
1 stop26h 12m
United Airlines
Deal found 4/6![United Airlines logo]()
$518
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/308:30 am
MCI
- PTY
1 stop10h 07m
United Airlines
Tue 6/93:30 pm
PTY
- MCI
1 stop18h 33m
United Airlines
Deal found 4/4![United Airlines logo]()
$528
One-way flights from Missouri to Panama CitySearch for one-way flight options from Missouri to Panama City. Find affordable one-way fares based on user searches. Data last updated April 10, 2026.
Search for one-way flight options from Missouri to Panama City. Find affordable one-way fares based on user searches. Data last updated April 10, 2026.
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:16 am
MCI
- PTY
1 stop9h 56m
United Airlines
Deal found 4/5![United Airlines logo]()
$201
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/63:18 pm
MCI
- PTY
2 stops23h 02m
American Airlines
Deal found 4/9![American Airlines logo]()
$206
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/68:30 am
MCI
- PTY
1 stop7h 42m
United Airlines
Deal found 4/9![United Airlines logo]()
$211
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:54 pm
STL
- PTY
2 stops17h 52m
American Airlines
Deal found 4/8![American Airlines logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:27 pm
STL
- PTY
3 stops39h 48m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$240
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:16 am
MCI
- PTY
1 stop12h 21m
United Airlines
Deal found 4/9![United Airlines logo]()
$245
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:28 pm
MCI
- PTY
2 stops18h 18m
American Airlines
Deal found 4/6![American Airlines logo]()
$247
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/197:55 pm
MCI
- PTY
2 stops22h 42m
United Airlines
Deal found 4/7![United Airlines logo]()
$250
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:56 pm
MCI
- PTY
2 stops23h 41m
United Airlines
Deal found 4/9![United Airlines logo]()
$275
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:03 pm
MCI
- PTY
2 stops42h 11m
American Airlines
Deal found 4/7![American Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:24 pm
MCI
- PTY
3 stops30h 11m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$321
Find flight deals from Missouri to Panama City
Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated April 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $471 (United Airlines) |
One-way from | $201 (United Airlines) |
Popular in | December |
Cheapest in | April |
Average price | $488 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
Use the filters below to find and compare flights from Missouri to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
Mon 8/17
6:23 am-2:14 pm
1 stop7h 51m
Panama City Tocumen Intl
Thu 8/20
10:55 pm-6:42 pm
2 stops19h 47m
$471
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
Sun 6/7
8:30 am-2:14 pm
1 stop29h 44m
Panama City Tocumen Intl
Wed 6/10
3:30 pm-10:03 am
1 stop18h 33m
$496
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Wed 5/6
6:00 am-1:02 pm
1 stop7h 02m
Panama City Tocumen Intl
Wed 5/13
2:15 pm-11:59 pm
1 stop9h 44m
$505
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Mon 5/4
6:00 am-4:12 pm
1 stop10h 12m
Panama City Tocumen Intl
Wed 5/20
10:00 am-10:30 pm
1 stop12h 30m
$505
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
Sat 8/1
6:00 am-4:04 am
2 stops22h 04m
Panama City Tocumen Intl
Mon 8/10
3:30 pm-9:07 am
2 stops17h 37m
$505
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
Sat 5/30
6:36 pm-4:12 pm
2 stops21h 36m
Panama City Tocumen Intl
Tue 6/9
3:30 pm-10:03 am
1 stop18h 33m
$505
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Thu 5/14
6:00 am-6:37 pm
1 stop12h 37m
Panama City Tocumen Intl
Sun 5/17
7:55 am-10:30 pm
1 stop14h 35m
$522
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Mon 5/25
8:15 pm-7:31 pm
2 stops23h 16m
Panama City Tocumen Intl
Thu 5/28
10:00 am-8:42 pm
1 stop10h 42m
$552
Quickest round-trip
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Sun 5/17
6:00 am-12:50 pm
1 stop6h 50m
Panama City Tocumen Intl
Mon 6/1
2:15 pm-9:38 pm
1 stop7h 23m
$576
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Wed 5/20
6:00 am-12:50 pm
1 stop6h 50m
Panama City Tocumen Intl
Tue 5/26
2:15 pm-9:38 pm
1 stop7h 23m
$588
Showing 1-10 of 24 resultsSorted by cheapest first
Best time to book a flight from Missouri to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.
MCI-PTY
STL-PTY
SGF-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Panama City
USMO-PTY
MCI-PTY
STL-PTY
SGF-PTY
What is the cheapest month to book a flight from Missouri to Panama City?
Currently, June is the cheapest month in which you can book a flight from Missouri to Panama City (average of $194). Flying from Missouri to Panama City in May is currently the most expensive (average of $451). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Panama City?
Related info for your journey
Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to Panama City
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Panama City by cabin class
Find flights from Missouri to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and Panama City flights
Browse other Missouri and Panama City flight options. Last updated on April 10, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Panama City flights
Consider these flights traveling from Missouri to Panama City.
Top 3 airlines flying from Missouri to Panama City
Discover the top 3 airlines that operate flights from Missouri to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$373 | Average$549 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$393 | Average$586 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$393 | Average$601 | FlexibilityNo cancel fee | On-time71% |