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Panama City

$181+ Cheap flights from Missouri to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Mar 22 — Mar 291
Sun 3/22
Sun 3/29
1 adult, Economy
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Cheap flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2026.

This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:00 am
STL
-
PTY
1 stop12h 38m
United Airlines
Tue 3/313:30 pm
PTY
-
STL
1 stop17h 55m
United Airlines
Deal found 2/17$425
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:15 am
MCI
-
PTY
1 stop7h 59m
United Airlines
Wed 5/2010:00 am
PTY
-
MCI
1 stop12h 29m
United Airlines
Deal found 2/17$427
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:17 am
MCI
-
PTY
2 stops12h 20m
United Airlines
Thu 5/213:30 pm
PTY
-
MCI
2 stops17h 37m
United Airlines
Deal found 2/17$431
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:45 am
STL
-
PTY
2 stops10h 52m
United Airlines
Sat 4/257:55 am
PTY
-
STL
1 stop14h 33m
United Airlines
Deal found 2/17$433
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/102:59 pm
MCI
-
PTY
1 stop25h 13m
United Airlines
Wed 5/2010:00 am
PTY
-
MCI
1 stop12h 29m
United Airlines
Deal found 2/17$435
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:50 am
STL
-
PTY
1 stop28h 55m
United Airlines
Wed 11/44:41 pm
PTY
-
STL
2 stops16h 56m
United Airlines
Deal found 2/17$437
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:28 pm
MCI
-
PTY
2 stops18h 18m
American Airlines
Fri 5/221:14 pm
PTY
-
MCI
2 stops21h 22m
American Airlines
Deal found 2/18$441
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:00 am
STL
-
PTY
1 stop10h 12m
United Airlines
Mon 4/133:30 pm
PTY
-
STL
1 stop17h 55m
United Airlines
Deal found 2/17$442
This United Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:00 am
STL
-
PTY
1 stop12h 38m
United Airlines
Wed 4/157:55 am
PTY
-
STL
1 stop14h 33m
United Airlines
Deal found 2/18$445
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:40 am
MCI
-
PTY
1 stop7h 15m
Delta
Thu 5/212:20 pm
PTY
-
MCI
1 stop8h 03m
Delta
Deal found 2/17$447
This United Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/306:30 am
MCI
-
PTY
1 stop12h 07m
United Airlines
Mon 5/410:00 am
PTY
-
MCI
1 stop12h 29m
United Airlines
Deal found 2/16$448
This United Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/297:45 am
STL
-
PTY
2 stops10h 52m
United Airlines
Wed 5/610:00 am
PTY
-
STL
1 stop12h 30m
United Airlines
Deal found 2/18$449

Find flight deals from Missouri to Panama City

Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated February 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$425
(United Airlines)

One-way from

$181
(United Airlines)

Popular in

December

Cheapest in

April

Average price

$642
Provider with most accurate pricing for Lambert-St Louis-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City Tocumen Intl flights.
Search Deals
From Missouri to Panama City Tocumen Intl
Search Deals
One-way flight from Missouri to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($45 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2026.
Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Missouri

Fly to

Panama City

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

6:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Wed 5/6

10:00 am-10:30 pm

1 stop12h 30m

$425

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

6:00 am-1:02 pm

1 stop7h 02m

Panama City Tocumen Intl

Wed 5/6

2:27 pm-11:36 pm

1 stop9h 09m

$425

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 3/24

6:00 am-6:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Tue 3/31

3:30 pm-9:25 am

1 stop17h 55m

$425

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 3/25

6:00 am-6:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Wed 4/15

7:55 am-4:08 pm

1 stop8h 13m

$425

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Mon 5/11

6:38 pm-12:55 pm

1 stop18h 17m

Panama City Tocumen Intl

Wed 5/20

2:20 pm-11:49 pm

1 stop9h 29m

$427

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Mon 5/11

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Tue 5/19

9:45 am-10:18 pm

1 stop12h 33m

$427

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 3/24

5:51 pm-12:40 pm

2 stops18h 49m

Panama City Tocumen Intl

Tue 3/31

1:40 pm-8:35 am

2 stops18h 55m

$429

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 5/28

6:00 am-6:37 pm

2 stops12h 37m

Panama City Tocumen Intl

Mon 6/1

3:30 pm-3:46 pm

2 stops24h 16m

$429

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 5/7

6:17 am-6:37 pm

2 stops12h 20m

Panama City Tocumen Intl

Mon 5/18

3:30 pm-9:01 am

2 stops17h 31m

$431

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 5/7

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Thu 5/21

3:30 pm-9:07 am

2 stops17h 37m

$431

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/16

Showing 1-10 of 28 results
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Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City?

Currently, June is the cheapest month in which you can book a flight from Missouri to Panama City (average of $198). Flying from Missouri to Panama City in May is currently the most expensive (average of $450). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Missouri to Panama City?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Missouri?

    If you book a flight to Panama City from Missouri, you will be flying to Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.

  • How long is the flight from Missouri to Panama City?

    Departing from Missouri to Panama City will take you 7h 02m. Missouri and Panama City are separated by a distance of 2159 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Missouri to Panama City?

    While some choose either Kansas City - Panama City Tocumen Intl or Springfield-Branson - Panama City Tocumen Intl, Lambert-St Louis - Panama City Tocumen Intl is the most popular route from Missouri to Panama City.

  • Can I find deals for flights from Missouri to Panama City that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.

  • Can I find deals for business class flights from Missouri to Panama City?

    Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama City?

    Currently, June is the cheapest month in which you can book a flight from Missouri to Panama City (average of $198). Flying from Missouri to Panama City in May is currently the most expensive (average of $450). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Panama City

Discover the top 3 airlines that operate flights from Missouri to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$227Average$553FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$393Average$579FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$393Average$591FlexibilityNo cancel feeOn-time71%

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