What are the cheapest airlines to fly from Missouri to Panama City one-way?

For one-way options, check prices for Delta. According to our data, you can fly for as low as $160. Users have also found prices from $161 and $164 on United Airlines and American Airlines, respectively.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the most popular routes from Missouri to Panama City?

While some choose either Kansas City - Panama City Tocumen Intl or Springfield-Branson - Panama City Tocumen Intl, Lambert-St Louis - Panama City Tocumen Intl is the most popular route from Missouri to Panama City.

What are the most popular airlines that fly from Missouri to Panama City?

When booking a flight from Missouri to Panama City, you may want to consider flying on American Airlines, Delta or United Airlines as they are the most popular for this route.

How far in advance should I book a flight from Missouri to Panama City?

Users have found that booking a flight from Missouri to Panama City at least 53 days early can save you up to 11% on average compared to booking a flight this week. If booking 53 days before your flight isn’t an option for you, users have found flights from Missouri to Panama City for as little as $493 when booking for a departure date within the next two weeks. You can also check prices now. Some users have found airline tickets as low as $667 for flights departing within the next 3 days.

What is the cheapest month to fly from Missouri to Panama City?

Due to multiple factors, expect to potentially pay more when booking in December. For low rates, October can be a great choice for travel to Panama City. Flights to Panama City from Missouri in October are about $627 on average during October, but can be found for as low as $445.

What airport do you fly into for flights to Panama City from Missouri?

If you book a flight to Panama City from Missouri, you will be flying to Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.

Can I find deals for flights from Missouri to Panama City that include hotel bookings?

Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.

Can I find deals for business class flights from Missouri to Panama City?

Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$160+ Flights from Missouri to Panama City

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Cheap flight deals from Missouri to Panama City

Round-trip from	$378 (American Airlines)
One-way from	$160 (Delta)
Popular in	December
Cheapest in	October
Average price	$540

From Missouri to Panama City Tocumen Intl

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One-way flight from Missouri to Panama City Tocumen Intl

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Highest demand for flights based on searches. 12% potential increase in price ($86 potential increase over avg. RT price).

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Cheapest flight prices on average. 4% potential price decrease ($25 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Wed 10/15:06 amMCI - PTY

1 stop7h 49mAmerican Airlines

Fri 1/232:45 pmPTY - MCI

2 stops20h 02mAmerican Airlines

Deal found 7/1

$378

Mon 7/288:25 amSTL - PTY

1 stop10h 12mUnited Airlines

Wed 8/63:30 pmPTY - STL

1 stop17h 58mUnited Airlines

Deal found 6/29

$390

Mon 9/86:00 amSTL - PTY

1 stop6h 50mDelta

Wed 9/172:10 pmPTY - STL

1 stop7h 50mDelta

Deal found 6/30

$393

Wed 10/15:45 amMCI - PTY

1 stop7h 10mDelta

Fri 1/233:27 pmPTY - MCI

1 stop9h 34mDelta

Deal found 7/1

$393

Mon 7/284:28 pmSTL - PTY

2 stops20h 26mAmerican Airlines

Wed 8/63:30 pmPTY - STL

2 stops24h 12mAmerican Airlines

Deal found 6/29

$399

Wed 11/126:15 amMCI - PTY

1 stop12h 23mUnited Airlines

Tue 11/254:41 pmPTY - MCI

2 stops17h 15mUnited Airlines

Deal found 7/1

$413

Thu 8/146:00 amMCI - PTY

2 stops18h 10mMultiple Airlines

Wed 8/203:20 amPTY - MCI

2 stops19h 33mMultiple Airlines

Deal found 6/30

$523

Sat 11/159:00 amSGF - PTY

1 stop9h 38mUnited Airlines

Tue 11/188:55 amPTY - SGF

1 stop10h 29mUnited Airlines

Deal found 6/29

$541

Fri 8/156:01 pmSGF - PTY

2 stops20h 29mAmerican Airlines

Fri 8/223:30 pmPTY - SGF

2 stops17h 14mAmerican Airlines

Deal found 7/1

$566

Best flights from Missouri to Panama City
Discover carefully curated flight deals from Missouri to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 1, 2025.

Wed 10/15:06 amMCI - PTY

1 stop7h 49mAmerican Airlines

Fri 1/232:45 pmPTY - MCI

2 stops20h 02mAmerican Airlines

Deal found 7/1

$378

Mon 7/288:25 amSTL - PTY

1 stop10h 12mUnited Airlines

Wed 8/63:30 pmPTY - STL

1 stop17h 58mUnited Airlines

Deal found 6/29

$390

Mon 9/86:00 amSTL - PTY

1 stop6h 50mDelta

Wed 9/172:10 pmPTY - STL

1 stop7h 50mDelta

Deal found 6/30

$393

Thu 8/146:00 amMCI - PTY

2 stops18h 10mMultiple Airlines

Wed 8/203:20 amPTY - MCI

2 stops19h 33mMultiple Airlines

Deal found 6/30

$523

Wed 10/15:45 amMCI - PTY

1 stop7h 10mDelta

Fri 1/233:27 pmPTY - MCI

1 stop9h 34mDelta

Deal found 7/1

$393

Mon 7/284:28 pmSTL - PTY

2 stops20h 26mAmerican Airlines

Wed 8/63:30 pmPTY - STL

2 stops24h 12mAmerican Airlines

Deal found 6/29

$399

Wed 11/126:15 amMCI - PTY

1 stop12h 23mUnited Airlines

Tue 11/254:41 pmPTY - MCI

2 stops17h 15mUnited Airlines

Deal found 7/1

$413

Sat 11/159:00 amSGF - PTY

1 stop9h 38mUnited Airlines

Tue 11/188:55 amPTY - SGF

1 stop10h 29mUnited Airlines

Deal found 6/29

$541

Fri 8/156:01 pmSGF - PTY

2 stops20h 29mAmerican Airlines

Fri 8/223:30 pmPTY - SGF

2 stops17h 14mAmerican Airlines

Deal found 7/1

$566

Last-minute flights from Missouri to Panama City
Discover last-minute flight deals from Missouri to Panama City. Data last updated July 1, 2025 and is based on user searches.

Sun 7/65:08 amMCI - PTY

1 stop7h 46mAmerican Airlines

Sun 7/133:10 pmPTY - MCI

2 stops19h 54mAmerican Airlines

Deal found 6/29

$686

Sun 7/66:05 amMCI - PTY

2 stops34h 10mMultiple Airlines

Sun 7/1311:05 amPTY - MCI

3 stops30h 04mMultiple Airlines

Deal found 6/29

$992

Tue 7/85:48 pmSTL - PTY

2 stops19h 06mAmerican Airlines

Fri 7/113:10 pmPTY - STL

2 stops18h 08mAmerican Airlines

Deal found 6/30

$616

Tue 7/86:30 amMCI - PTY

1 stop12h 07mUnited Airlines

Tue 7/227:55 amPTY - MCI

1 stop14h 05mUnited Airlines

Deal found 6/29

$641

Wed 7/911:24 amSTL - PTY

2 stops29h 06mMultiple Airlines

Sat 7/123:20 amPTY - STL

3 stops30h 32mMultiple Airlines

Deal found 6/30

$991

Wed 7/98:15 amSTL - PTY

2 stops36h 55mAvianca

Sat 7/123:20 amPTY - STL

2 stops30h 39mAvianca

Deal found 6/30

$3,328

Thu 7/108:25 amSTL - PTY

1 stop7h 47mUnited Airlines

Thu 7/177:55 amPTY - STL

1 stop14h 20mUnited Airlines

Deal found 7/1

$590

Thu 7/108:15 amSTL - PTY

1 stop12h 19mCopa Airlines

Mon 7/1410:29 pmPTY - STL

1 stop11h 30mCopa Airlines

Deal found 7/1

$2,225

Sun 7/275:45 amMCI - PTY

1 stop7h 28mDelta

Sat 8/28:10 amPTY - MCI

1 stop9h 18mDelta

Deal found 7/1

$564

Mon 7/288:25 amSTL - PTY

1 stop10h 12mUnited Airlines

Wed 8/63:30 pmPTY - STL

1 stop17h 58mUnited Airlines

Deal found 6/29

$390

Mon 7/284:28 pmSTL - PTY

2 stops20h 26mAmerican Airlines

Wed 8/63:30 pmPTY - STL

2 stops24h 12mAmerican Airlines

Deal found 6/29

$399

Sat 8/26:30 pmMCI - PTY

2 stops18h 24mAmerican Airlines

Sat 8/163:30 pmPTY - MCI

2 stops21h 52mAmerican Airlines

Deal found 7/1

$482

One-way flights from Missouri to Panama City
Search for one-way flight options from Missouri to Panama City. Find affordable one-way fares based on user searches. Data last updated July 1, 2025.

Tue 9/96:00 amSTL - PTY

1 stop6h 50mDelta

Deal found 6/30

$160

Mon 9/86:15 amSTL - PTY

1 stop12h 22mUnited Airlines

Deal found 6/30

$161

Mon 9/81:21 pmSTL - PTY

2 stops23h 34mAmerican Airlines

Deal found 6/30

$164

Sun 7/135:26 pmSTL - PTY

3 stops40h 59mMultiple Airlines

Deal found 6/29

$238

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 10/1

5:06 am-12:55 pm

1 stop7h 49m

Panama City Tocumen Intl

Fri 1/23

2:45 pm-9:47 am

2 stops20h 02m

$378

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 7/28

8:25 am-6:37 pm

1 stop10h 12m

Panama City Tocumen Intl

Wed 8/6

3:30 pm-9:28 am

1 stop17h 58m

$390

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 9/8

6:00 am-12:50 pm

1 stop6h 50m

Panama City Tocumen Intl

Thu 9/18

2:10 pm-11:24 pm

1 stop9h 14m

$393

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 10/1

5:45 am-12:55 pm

1 stop7h 10m

Panama City Tocumen Intl

Fri 1/23

3:27 pm-12:01 am

1 stop9h 34m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 7/28

4:28 pm-12:54 pm

2 stops20h 26m

Panama City Tocumen Intl

Wed 8/6

3:30 pm-3:42 pm

2 stops24h 12m

$399

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 11/12

8:00 am-7:38 pm

2 stops10h 38m

Panama City Tocumen Intl

Wed 11/26

4:41 pm-2:21 pm

2 stops22h 40m

$413

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 8/14

6:00 am-12:10 am

2 stops18h 10m

Panama City Tocumen Intl

Wed 8/20

3:20 am-10:53 pm

2 stops19h 33m

$523

SpringfieldPanama City

SGF - PTY

SGFPTY

Springfield-Branson

Sat 11/15

9:00 am-7:38 pm

1 stop9h 38m

Panama City Tocumen Intl

Tue 11/18

8:55 am-6:24 pm

1 stop10h 29m

$541

SpringfieldPanama City

SGF - PTY

SGFPTY

Springfield-Branson

Fri 8/15

6:01 pm-2:30 pm

2 stops20h 29m

Panama City Tocumen Intl

Fri 8/22

3:30 pm-8:44 am

2 stops17h 14m

$566

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 9/9

6:00 am-12:50 pm

1 stop6h 50m

$160

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Showing 1-10 of 16 results

Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City?

Currently, October is the cheapest month in which you can book a flight from Missouri to Panama City (average of $478). Flying from Missouri to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to PTY?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Panama City as you normally would.

How much does it cost to fly round-trip from Missouri to Panama City?

Reviews of airlines servicing Panama City

Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Missouri to Panama City by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,973 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,973 reviews

Delta

8.0

Very good

7,973 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,858 reviews

Delta

8.0

Very good

7,973 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,973 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What airport do you fly into for flights to Panama City from Missouri?
If you book a flight to Panama City from Missouri, you will be flying to Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.
What are the cheapest airlines to fly from Missouri to Panama City one-way?
For one-way options, check prices for Delta. According to our data, you can fly for as low as $160. Users have also found prices from $161 and $164 on United Airlines and American Airlines, respectively.
What are the most popular routes from Missouri to Panama City?
While some choose either Kansas City - Panama City Tocumen Intl or Springfield-Branson - Panama City Tocumen Intl, Lambert-St Louis - Panama City Tocumen Intl is the most popular route from Missouri to Panama City.
Can I find deals for flights from Missouri to Panama City that include hotel bookings?
Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.
Can I find deals for business class flights from Missouri to Panama City?
Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Missouri to Panama City?
Currently, October is the cheapest month in which you can book a flight from Missouri to Panama City (average of $478). Flying from Missouri to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Missouri to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$373	Average$563	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$394	Average$568	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$397	Average$582	FlexibilityNo cancel fee	On-time69%

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$160+ Cheap flights from Missouri to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/9. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Missouri to Panama City with Cheapflights

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Cheap flight deals from Missouri to Panama City

Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated July 1, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama CityExplore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City?

What is the cheapest time of day to fly from MO to PTY?

Find hourly flight availability from Missouri to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 1, 2025.

How much does it cost to fly round-trip from Missouri to Panama City?

Reviews of airlines servicing Panama City

Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Missouri to Panama City by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Panama City from Missouri?

What are the cheapest airlines to fly from Missouri to Panama City one-way?

What are the most popular routes from Missouri to Panama City?

Can I find deals for flights from Missouri to Panama City that include hotel bookings?

How can I find direct flights from Missouri to Panama City?

Can I find deals for business class flights from Missouri to Panama City?

What is the cheapest month to book a flight from Missouri to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Missouri to Panama City

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Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.