How long is the flight from Missouri to Panama City?

Departing from Missouri to Panama City will take you 6h 55m. Missouri and Panama City are separated by a distance of 2159 mi. This flight may include one or multiple stops.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the most popular routes from Missouri to Panama City?

While some choose either Lambert-St Louis - Panama City Tocumen Intl or Springfield-Branson - Panama City Tocumen Intl, Kansas City - Panama City Tocumen Intl is the most popular route from Missouri to Panama City.

What are the most popular airlines that fly from Missouri to Panama City?

When booking a flight from Missouri to Panama City, you may want to consider flying on United Airlines, Delta or American Airlines as they are the most popular for this route.

What airport do you fly into for flights to Panama City from Missouri?

If you book a flight to Panama City from Missouri, you will be flying to Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.

Can I find deals for flights from Missouri to Panama City that include hotel bookings?

Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.

Can I find deals for business class flights from Missouri to Panama City?

Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$186+ Flights from Missouri to Panama City

Q: How much does it cost to fly round-trip from Missouri to Panama City?

Airfare is below average for this route at the moment. Missouri to Panama City flights typically cost between $562 and $774 in April. The cheapest round-trip price found within the last 3 days was $394 on Delta (Apr 29-May 6).

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Cheap flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 25, 2025.

Sat 12/278:01 pmSTL - PTY

2 stops18h 53mAmerican Airlines

Mon 12/294:55 pmPTY - STL

2 stops21h 28mAmerican Airlines

Deal found 12/23

$656

Wed 12/248:00 amMCI - PTY

1 stop11h 00mDelta

Mon 12/298:00 amPTY - MCI

1 stop14h 08mDelta

Deal found 12/23

$688

Wed 12/246:15 amMCI - PTY

1 stop12h 23mUnited Airlines

Mon 12/298:55 amPTY - MCI

2 stops13h 55mUnited Airlines

Deal found 12/23

$692

Wed 12/245:43 amMCI - PTY

1 stop13h 17mDelta

Sun 12/283:22 pmPTY - MCI

1 stop9h 34mDelta

Deal found 12/23

$708

Wed 12/246:15 amMCI - PTY

1 stop12h 23mUnited Airlines

Sun 12/284:41 pmPTY - MCI

2 stops22h 57mUnited Airlines

Deal found 12/23

$712

Tue 12/238:09 amMCI - PTY

1 stop7h 58mUnited Airlines

Mon 1/54:41 pmPTY - MCI

2 stops22h 46mUnited Airlines

Deal found 12/23

$938

Sat 12/275:45 pmSTL - PTY

1 stop20h 00mUnited Airlines

Mon 12/294:41 pmPTY - STL

1 stop18h 08mUnited Airlines

Deal found 12/23

$1,040

Wed 12/246:15 pmMCI - PTY

3 stops21h 40mMultiple Airlines

Sun 12/285:50 pmPTY - MCI

2 stops24h 20mMultiple Airlines

Deal found 12/23

$1,241

Wed 12/246:15 pmMCI - PTY

3 stops21h 40mMultiple Airlines

Mon 12/299:45 amPTY - MCI

3 stops32h 25mMultiple Airlines

Deal found 12/23

$1,244

Sat 12/278:15 amSTL - PTY

2 stops31h 40mMultiple Airlines

Mon 12/2911:25 amPTY - STL

3 stops37h 26mMultiple Airlines

Deal found 12/23

$8,201

Best flights from Missouri to Panama City
Discover carefully curated flight deals from Missouri to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 25, 2025.

Tue 2/176:00 amSTL - PTY

1 stop12h 38mUnited Airlines

Wed 2/254:41 pmPTY - STL

1 stop17h 42mUnited Airlines

Deal found 12/24

$394

Mon 4/276:00 amSTL - PTY

1 stop6h 55mDelta

Wed 5/62:20 pmPTY - STL

1 stop17h 47mDelta

Deal found 12/25

$394

Wed 3/46:00 amSTL - PTY

1 stop7h 45mUnited Airlines

Tue 3/107:55 amPTY - STL

1 stop14h 21mUnited Airlines

Deal found 12/24

$394

Mon 4/276:59 pmSTL - PTY

1 stop17h 56mDelta

Tue 5/52:20 pmPTY - STL

1 stop9h 13mDelta

Deal found 12/25

$394

Wed 4/296:00 amSTL - PTY

1 stop10h 12mUnited Airlines

Mon 5/47:55 amPTY - STL

1 stop14h 31mUnited Airlines

Deal found 12/25

$394

Sun 4/266:59 pmSTL - PTY

1 stop17h 56mDelta

Wed 5/62:20 pmPTY - STL

1 stop9h 13mDelta

Deal found 12/25

$394

Thu 4/306:00 amSTL - PTY

1 stop8h 14mUnited Airlines

Mon 5/410:00 amPTY - STL

1 stop12h 26mUnited Airlines

Deal found 12/25

$394

Tue 4/286:00 amSTL - PTY

1 stop6h 55mDelta

Thu 5/72:20 pmPTY - STL

1 stop9h 18mDelta

Deal found 12/25

$394

Thu 4/306:00 amSTL - PTY

1 stop12h 37mUnited Airlines

Wed 5/67:55 amPTY - STL

1 stop14h 31mUnited Airlines

Deal found 12/25

$394

Wed 4/296:00 amSTL - PTY

1 stop6h 55mDelta

Wed 5/62:20 pmPTY - STL

1 stop9h 13mDelta

Deal found 12/24

$394

Sun 4/266:59 pmSTL - PTY

1 stop17h 56mDelta

Thu 5/72:20 pmPTY - STL

1 stop17h 47mDelta

Deal found 12/25

$394

Mon 2/210:30 amMCI - PTY

1 stop8h 08mUnited Airlines

Wed 2/44:41 pmPTY - MCI

1 stop17h 50mUnited Airlines

Deal found 12/22

$438

Mon 2/98:05 amMCI - PTY

1 stop10h 33mUnited Airlines

Fri 2/134:41 pmPTY - MCI

1 stop17h 51mUnited Airlines

Deal found 12/23

$444

Sat 2/73:14 pmSGF - PTY

2 stops24h 53mUnited Airlines

Tue 2/104:41 pmPTY - SGF

2 stops22h 57mUnited Airlines

Deal found 12/22

$566

Wed 2/257:55 amSGF - PTY

2 stops10h 43mUnited Airlines

Sun 3/14:41 pmPTY - SGF

2 stops22h 59mUnited Airlines

Deal found 12/23

$566

Last-minute flights from Missouri to Panama City
Discover last-minute flight deals from Missouri to Panama City. Data last updated December 25, 2025 and is based on user searches.

Wed 12/248:00 amMCI - PTY

1 stop11h 00mDelta

Mon 12/298:00 amPTY - MCI

1 stop14h 08mDelta

Deal found 12/23

$688

Wed 12/246:15 amMCI - PTY

1 stop12h 23mUnited Airlines

Mon 12/298:55 amPTY - MCI

2 stops13h 55mUnited Airlines

Deal found 12/23

$692

Wed 12/245:43 amMCI - PTY

1 stop13h 17mDelta

Sun 12/283:22 pmPTY - MCI

1 stop9h 34mDelta

Deal found 12/23

$708

Sat 12/278:01 pmSTL - PTY

2 stops18h 53mAmerican Airlines

Mon 12/294:55 pmPTY - STL

2 stops21h 28mAmerican Airlines

Deal found 12/23

$656

Sat 1/36:00 amSTL - PTY

1 stop12h 38mUnited Airlines

Sun 1/114:41 pmPTY - STL

1 stop30h 19mUnited Airlines

Deal found 12/23

$641

Sat 1/36:44 pmSTL - PTY

2 stops20h 10mAmerican Airlines

Sun 1/112:27 pmPTY - STL

2 stops21h 38mAmerican Airlines

Deal found 12/24

$690

Mon 1/56:00 amSTL - PTY

1 stop7h 45mUnited Airlines

Tue 1/274:41 pmPTY - STL

1 stop17h 41mUnited Airlines

Deal found 12/23

$503

Thu 1/88:05 amMCI - PTY

1 stop8h 02mUnited Airlines

Tue 2/38:55 amPTY - MCI

1 stop8h 58mUnited Airlines

Deal found 12/24

$525

Thu 1/85:49 pmMCI - PTY

2 stops20h 49mAmerican Airlines

Tue 2/32:27 pmPTY - MCI

2 stops22h 30mAmerican Airlines

Deal found 12/24

$529

Wed 1/148:05 amMCI - PTY

1 stop8h 02mUnited Airlines

Tue 1/204:41 pmPTY - MCI

1 stop25h 12mUnited Airlines

Deal found 12/23

$533

Sat 1/176:30 pmMCI - PTY

2 stops24h 08mUnited Airlines

Sun 1/254:41 pmPTY - MCI

1 stop17h 50mUnited Airlines

Deal found 12/24

$569

Sat 1/175:49 pmMCI - PTY

2 stops20h 49mAmerican Airlines

Sun 1/254:50 pmPTY - MCI

2 stops21h 15mAmerican Airlines

Deal found 12/24

$600

One-way flights from Missouri to Panama City
Search for one-way flight options from Missouri to Panama City. Find affordable one-way fares based on user searches. Data last updated December 25, 2025.

Mon 6/86:37 pmMCI - PTY

2 stops19h 37mUnited Airlines

Deal found 12/22

$186

Thu 3/196:33 pmMCI - PTY

2 stops17h 49mAmerican Airlines

Deal found 12/23

$192

Thu 3/196:15 amMCI - PTY

1 stop7h 30mUnited Airlines

Deal found 12/24

$212

Wed 1/78:50 amSGF - PTY

1 stop9h 48mUnited Airlines

Deal found 12/23

$268

Mon 1/59:00 amSGF - PTY

1 stop7h 07mUnited Airlines

Deal found 12/23

$291

Sun 1/43:00 pmSGF - PTY

1 stop25h 07mUnited Airlines

Deal found 12/23

$306

Sat 1/33:14 pmSGF - PTY

2 stops22h 31mUnited Airlines

Deal found 12/23

$311

Tue 1/64:29 pmSGF - PTY

2 stops19h 58mAmerican Airlines

Deal found 12/23

$323

Mon 2/236:15 amMCI - PTY

1 stop7h 30mUnited Airlines

Deal found 12/24

$332

Mon 5/114:45 pmMCI - PTY

2 stops19h 30mAmerican Airlines

Deal found 12/24

$367

Mon 6/812:12 pmMCI - PTY

3 stops35h 58mMultiple Airlines

Deal found 12/22

$377

Mon 1/59:47 pmSGF - PTY

3 stops44h 08mMultiple Airlines

Deal found 12/23

$422

Find flight deals from Missouri to Panama City

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$394 (Delta)
One-way from	$186 (United Airlines)
Popular in	December
Cheapest in	April
Average price	$719

Provider with most accurate pricing for Lambert-St Louis-Panama City Tocumen Intl flight deals.

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Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City Tocumen Intl flights.

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From Missouri to Panama City Tocumen Intl

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One-way flight from Missouri to Panama City Tocumen Intl

Search Deals

Highest demand for flights based on searches. 6% potential increase in price ($40 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 2/17

6:00 am-7:38 pm

1 stop12h 38m

Panama City Tocumen Intl

Wed 2/25

4:41 pm-9:23 am

1 stop17h 42m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 4/27

6:00 am-12:55 pm

1 stop6h 55m

Panama City Tocumen Intl

Wed 5/6

2:20 pm-8:07 am

1 stop17h 47m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 3/4

6:00 am-2:45 pm

1 stop7h 45m

Panama City Tocumen Intl

Tue 3/10

7:55 am-10:16 pm

1 stop14h 21m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 4/27

6:59 pm-12:55 pm

1 stop17h 56m

Panama City Tocumen Intl

Tue 5/5

2:20 pm-11:33 pm

1 stop9h 13m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

6:00 am-4:12 pm

1 stop10h 12m

Panama City Tocumen Intl

Mon 5/4

7:55 am-10:26 pm

1 stop14h 31m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 4/26

6:59 pm-12:55 pm

1 stop17h 56m

Panama City Tocumen Intl

Wed 5/6

2:20 pm-11:33 pm

1 stop9h 13m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 4/30

6:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Mon 5/4

10:00 am-10:26 pm

1 stop12h 26m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 4/28

6:00 am-12:55 pm

1 stop6h 55m

Panama City Tocumen Intl

Thu 5/7

2:20 pm-11:38 pm

1 stop9h 18m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 4/30

6:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Wed 5/6

7:55 am-10:26 pm

1 stop14h 31m

$394

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 4/29

6:00 am-12:55 pm

1 stop6h 55m

Panama City Tocumen Intl

Wed 5/6

2:20 pm-11:33 pm

1 stop9h 13m

$394

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/22

Showing 1-10 of 31 results

Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City?

Currently, June is the cheapest month in which you can book a flight from Missouri to Panama City (average of $201). Flying from Missouri to Panama City in March is currently the most expensive (average of $484). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to PTY?

A simple way to save on the total cost of your ticket is to fly from Missouri to Panama City at noon. If you’re flexible enough to do this you can expect to save up to 14% on your trip compared to booking a flight in the morning.

How much does it cost to fly round-trip from Missouri to Panama City?

Related info for your journey

What airport do you fly into for flights to Panama City from Missouri?
If you book a flight to Panama City from Missouri, you will be flying to Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.
How long is the flight from Missouri to Panama City?
Departing from Missouri to Panama City will take you 6h 55m. Missouri and Panama City are separated by a distance of 2159 mi. This flight may include one or multiple stops.
What are the most popular routes from Missouri to Panama City?
While some choose either Lambert-St Louis - Panama City Tocumen Intl or Springfield-Branson - Panama City Tocumen Intl, Kansas City - Panama City Tocumen Intl is the most popular route from Missouri to Panama City.
Can I find deals for flights from Missouri to Panama City that include hotel bookings?
Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.
Can I find deals for business class flights from Missouri to Panama City?
Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Missouri to Panama City?
Currently, June is the cheapest month in which you can book a flight from Missouri to Panama City (average of $201). Flying from Missouri to Panama City in March is currently the most expensive (average of $484). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Missouri to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$373	Average$569	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$393	Average$601	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$394	Average$595	FlexibilityNo cancel fee	On-time71%

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$186+ Cheap flights from Missouri to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/8. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama CityExplore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 25, 2025.

Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 25, 2025.

Find flight deals from Missouri to Panama City

Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated December 25, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City?

What is the cheapest time of day to fly from MO to PTY?

Find hourly flight availability from Missouri to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 25, 2025.

How much does it cost to fly round-trip from Missouri to Panama City?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Panama City from Missouri?

How long is the flight from Missouri to Panama City?

What are the most popular routes from Missouri to Panama City?

Can I find deals for flights from Missouri to Panama City that include hotel bookings?

How can I find direct flights from Missouri to Panama City?

Can I find deals for business class flights from Missouri to Panama City?

What is the cheapest month to book a flight from Missouri to Panama City?

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Alternative routes for Missouri to Panama City

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Top 3 airlines flying from Missouri to Panama City

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Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 25, 2025.