What are the cheapest airlines to fly from Missouri to Panama City one-way?

For one-way options, check prices for Delta. According to our data, you can fly for as low as $164. Users have also found prices from $170 and $200 on American Airlines and United Airlines, respectively.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the most popular routes from Missouri to Panama City?

While some choose either Kansas City - Panama City Tocumen Intl or Springfield-Branson - Panama City Tocumen Intl, Lambert-St Louis - Panama City Tocumen Intl is the most popular route from Missouri to Panama City.

What are the most popular airlines that fly from Missouri to Panama City?

When booking a flight from Missouri to Panama City, you may want to consider flying on American Airlines, Delta or United Airlines as they are the most popular for this route.

How far in advance should I book a flight from Missouri to Panama City?

Users have found that booking a flight from Missouri to Panama City at least 53 days early can save you up to 11% on average compared to booking a flight this week. If booking 53 days before your flight isn’t an option for you, users have found flights from Missouri to Panama City for as little as $493 when booking for a departure date within the next two weeks. You can also check prices now. Some users have found airline tickets as low as $667 for flights departing within the next 3 days.

What is the cheapest month to fly from Missouri to Panama City?

Due to multiple factors, expect to potentially pay more when booking in December. For low rates, July can be a great choice for travel to Panama City. Flights to Panama City from Missouri in July are about $610 on average during July, but can be found for as low as $392.

What airport do you fly into for flights to Panama City from Missouri?

If you book a flight to Panama City from Missouri, you will be flying to Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.

Can I find deals for flights from Missouri to Panama City that include hotel bookings?

Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.

Can I find deals for business class flights from Missouri to Panama City?

Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$164+ Flights from Missouri to Panama City

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Cheap flight deals from Missouri to Panama City

Round-trip from	$393 (Delta)
One-way from	$164 (Delta)
Popular in	December
Cheapest in	July
Average price	$599

From Missouri to Panama City Tocumen Intl

Search Deals

One-way flight from Missouri to Panama City Tocumen Intl

Search Deals

Highest demand for flights based on searches. 11% potential increase in price ($78 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).

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Average for round-trip flights in August 2025

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Find flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Tue 9/96:00 amSTL - PTY

1 stop6h 50mDelta

Tue 9/162:10 pmPTY - STL

1 stop7h 50mDelta

Deal found 8/13

$393

Mon 9/155:30 pmSTL - PTY

2 stops20h 44mUnited Airlines

Mon 9/293:30 pmPTY - STL

2 stops19h 19mUnited Airlines

Deal found 8/14

$398

Fri 9/126:01 amSTL - PTY

1 stop6h 54mDelta

Tue 9/162:10 pmPTY - STL

1 stop7h 50mDelta

Deal found 8/14

$410

Fri 9/127:04 pmSTL - PTY

2 stops23h 33mUnited Airlines

Tue 9/163:30 pmPTY - STL

2 stops22h 49mUnited Airlines

Deal found 8/14

$415

Thu 10/24:36 pmSTL - PTY

2 stops21h 55mAmerican Airlines

Sun 10/53:31 pmPTY - STL

2 stops18h 38mAmerican Airlines

Deal found 8/13

$420

Sun 11/96:43 pmSTL - PTY

2 stops19h 02mUnited Airlines

Sun 11/164:41 pmPTY - STL

1 stop27h 06mUnited Airlines

Deal found 8/14

$423

Fri 9/126:01 amSTL - PTY

1 stop6h 54mDelta

Fri 9/192:10 pmPTY - STL

1 stop9h 14mDelta

Deal found 8/13

$427

Thu 10/28:25 amSTL - PTY

1 stop10h 12mUnited Airlines

Sun 10/510:00 amPTY - STL

1 stop12h 00mUnited Airlines

Deal found 8/13

$431

Sat 9/136:35 amSTL - PTY

2 stops12h 02mUnited Airlines

Sat 9/203:30 pmPTY - STL

2 stops20h 55mUnited Airlines

Deal found 8/14

$432

Wed 11/126:35 pmMCI - PTY

2 stops19h 10mUnited Airlines

Sun 11/238:55 amPTY - MCI

1 stop14h 33mUnited Airlines

Deal found 8/12

$433

Wed 11/128:10 amMCI - PTY

1 stop29h 35mUnited Airlines

Sun 11/168:55 amPTY - MCI

1 stop14h 33mUnited Airlines

Deal found 8/14

$436

Mon 9/156:01 amSTL - PTY

1 stop6h 54mDelta

Mon 9/292:10 pmPTY - STL

1 stop9h 14mDelta

Deal found 8/13

$437

Best flights from Missouri to Panama City
Discover carefully curated flight deals from Missouri to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2025.

Tue 9/96:00 amSTL - PTY

1 stop6h 50mDelta

Tue 9/162:10 pmPTY - STL

1 stop7h 50mDelta

Deal found 8/13

$393

Wed 9/107:04 pmSTL - PTY

2 stops23h 33mUnited Airlines

Wed 9/1710:00 amPTY - STL

1 stop8h 58mUnited Airlines

Deal found 8/13

$398

Wed 9/103:34 pmSTL - PTY

2 stops22h 57mAmerican Airlines

Wed 9/171:45 pmPTY - STL

2 stops18h 20mAmerican Airlines

Deal found 8/13

$398

Mon 9/155:30 pmSTL - PTY

2 stops20h 44mUnited Airlines

Mon 9/293:30 pmPTY - STL

2 stops19h 19mUnited Airlines

Deal found 8/13

$398

Fri 9/126:01 amSTL - PTY

1 stop6h 54mDelta

Tue 9/162:10 pmPTY - STL

1 stop7h 50mDelta

Deal found 8/14

$410

Fri 9/126:00 pmSTL - PTY

2 stops20h 31mAmerican Airlines

Fri 9/193:31 pmPTY - STL

1 stop8h 28mAmerican Airlines

Deal found 8/13

$415

Fri 9/126:15 amSTL - PTY

1 stop7h 59mUnited Airlines

Tue 9/163:30 pmPTY - STL

2 stops22h 49mUnited Airlines

Deal found 8/14

$415

Tue 9/95:45 amMCI - PTY

1 stop7h 05mDelta

Tue 9/162:10 pmPTY - MCI

1 stop9h 34mDelta

Deal found 8/12

$437

Wed 11/125:20 pmMCI - PTY

2 stops19h 16mAmerican Airlines

Sun 11/162:43 pmPTY - MCI

2 stops23h 00mAmerican Airlines

Deal found 8/14

$438

Thu 9/186:15 amSTL - PTY

1 stop12h 22mUnited Airlines

Sun 9/213:30 pmPTY - STL

2 stops20h 55mUnited Airlines

Deal found 8/13

$415

Wed 11/126:35 pmMCI - PTY

2 stops19h 10mUnited Airlines

Sun 11/238:55 amPTY - MCI

1 stop14h 33mUnited Airlines

Deal found 8/12

$433

Wed 11/126:35 pmMCI - PTY

2 stops19h 10mUnited Airlines

Sun 11/164:41 pmPTY - MCI

2 stops17h 15mUnited Airlines

Deal found 8/12

$433

Last-minute flights from Missouri to Panama City
Discover last-minute flight deals from Missouri to Panama City. Data last updated August 14, 2025 and is based on user searches.

Thu 8/218:30 amMCI - PTY

1 stop10h 07mUnited Airlines

Mon 8/253:30 pmPTY - MCI

2 stops22h 50mUnited Airlines

Deal found 8/11

$646

Thu 8/216:00 amMCI - PTY

3 stops18h 10mMultiple Airlines

Mon 8/2510:05 pmPTY - MCI

3 stops24h 48mMultiple Airlines

Deal found 8/11

$652

Fri 8/226:15 amSTL - PTY

1 stop7h 59mUnited Airlines

Sat 8/233:30 pmPTY - STL

1 stop18h 31mUnited Airlines

Deal found 8/13

$651

Fri 8/226:15 amSTL - PTY

1 stop12h 22mUnited Airlines

Sun 8/243:30 pmPTY - STL

2 stops20h 55mUnited Airlines

Deal found 8/13

$656

Fri 8/226:15 amSTL - PTY

1 stop7h 59mUnited Airlines

Mon 8/2510:00 amPTY - STL

1 stop8h 58mUnited Airlines

Deal found 8/13

$685

Fri 8/225:26 amSTL - PTY

1 stop9h 04mAmerican Airlines

Sun 8/243:30 pmPTY - STL

1 stop8h 29mAmerican Airlines

Deal found 8/13

$737

Fri 8/228:43 amSTL - PTY

2 stops29h 47mAmerican Airlines

Mon 8/253:30 pmPTY - STL

2 stops21h 24mAmerican Airlines

Deal found 8/13

$847

Fri 8/2210:26 amSTL - PTY

1 stop8h 57mMultiple Airlines

Fri 8/223:25 amPTY - STL

2 stops14h 44mMultiple Airlines

Deal found 8/13

$930

Fri 8/228:15 amSTL - PTY

3 stops30h 30mAvianca

Mon 8/258:10 pmPTY - STL

2 stops37h 52mAvianca

Deal found 8/13

$1,062

Fri 8/228:15 amSTL - PTY

3 stops30h 30mAvianca

Sat 8/238:10 pmPTY - STL

2 stops13h 52mAvianca

Deal found 8/13

$1,289

Fri 8/228:10 amSTL - PTY

2 stops10h 27mUnited Airlines

Fri 8/2210:55 pmPTY - STL

2 stops16h 49mUnited Airlines

Deal found 8/13

$1,318

Tue 9/96:00 amSTL - PTY

1 stop6h 50mDelta

Tue 9/162:10 pmPTY - STL

1 stop7h 50mDelta

Deal found 8/13

$393

One-way flights from Missouri to Panama City
Search for one-way flight options from Missouri to Panama City. Find affordable one-way fares based on user searches. Data last updated August 14, 2025.

Wed 9/176:01 amSTL - PTY

1 stop6h 54mDelta

Deal found 8/12

$164

Thu 9/183:34 pmSTL - PTY

2 stops22h 57mAmerican Airlines

Deal found 8/12

$170

Wed 11/51:40 pmMCI - PTY

2 stops22h 56mAmerican Airlines

Deal found 8/14

$196

Wed 11/58:10 amMCI - PTY

1 stop29h 35mUnited Airlines

Deal found 8/14

$200

Wed 9/175:25 pmSTL - PTY

2 stops21h 06mAmerican Airlines

Deal found 8/12

$214

Thu 9/184:00 pmSTL - PTY

3 stops29h 10mMultiple Airlines

Deal found 8/12

$242

Wed 8/276:35 amSTL - PTY

2 stops12h 02mUnited Airlines

Deal found 8/13

$248

Wed 11/57:00 amMCI - PTY

3 stops28h 50mMultiple Airlines

Deal found 8/14

$293

Sat 8/238:55 amSGF - PTY

1 stop9h 42mUnited Airlines

Deal found 8/12

$311

Wed 9/178:40 pmSTL - PTY

3 stops27h 30mMultiple Airlines

Deal found 8/12

$329

Tue 8/196:10 amSGF - PTY

1 stop12h 27mUnited Airlines

Deal found 8/14

$466

Thu 8/217:55 amSGF - PTY

2 stops10h 42mUnited Airlines

Deal found 8/13

$486

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 9/9

6:00 am-12:50 pm

1 stop6h 50m

Panama City Tocumen Intl

Tue 9/16

2:10 pm-10:00 pm

1 stop7h 50m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 9/10

7:04 pm-6:37 pm

2 stops23h 33m

Panama City Tocumen Intl

Wed 9/17

10:00 am-6:58 pm

1 stop8h 58m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 9/10

3:34 pm-2:31 pm

2 stops22h 57m

Panama City Tocumen Intl

Wed 9/17

1:45 pm-8:05 am

2 stops18h 20m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 9/15

5:30 pm-2:14 pm

2 stops20h 44m

Panama City Tocumen Intl

Mon 9/29

3:30 pm-10:49 am

2 stops19h 19m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 9/12

6:01 am-12:55 pm

1 stop6h 54m

Panama City Tocumen Intl

Tue 9/16

2:10 pm-10:00 pm

1 stop7h 50m

$410

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 9/12

6:00 pm-2:31 pm

2 stops20h 31m

Panama City Tocumen Intl

Fri 9/19

3:31 pm-11:59 pm

1 stop8h 28m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 9/12

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Tue 9/16

3:30 pm-2:19 pm

2 stops22h 49m

$415

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 9/18

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Sun 9/21

3:30 pm-12:25 pm

2 stops20h 55m

$415

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 11/12

6:35 pm-2:45 pm

2 stops19h 10m

Panama City Tocumen Intl

Sun 11/23

8:55 am-10:28 pm

1 stop14h 33m

$433

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 11/12

6:35 pm-2:45 pm

2 stops19h 10m

Panama City Tocumen Intl

Sun 11/16

4:41 pm-8:56 am

2 stops17h 15m

$433

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/12

Showing 1-10 of 33 results

Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City?

Currently, October is the cheapest month in which you can book a flight from Missouri to Panama City (average of $478). Flying from Missouri to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to PTY?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Panama City as you normally would.

Related info for your journey

What airport do you fly into for flights to Panama City from Missouri?
If you book a flight to Panama City from Missouri, you will be flying to Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.
What are the cheapest airlines to fly from Missouri to Panama City one-way?
For one-way options, check prices for Delta. According to our data, you can fly for as low as $164. Users have also found prices from $170 and $200 on American Airlines and United Airlines, respectively.
What are the most popular routes from Missouri to Panama City?
While some choose either Kansas City - Panama City Tocumen Intl or Springfield-Branson - Panama City Tocumen Intl, Lambert-St Louis - Panama City Tocumen Intl is the most popular route from Missouri to Panama City.
Can I find deals for flights from Missouri to Panama City that include hotel bookings?
Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.
Can I find deals for business class flights from Missouri to Panama City?
Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Missouri to Panama City?
Currently, October is the cheapest month in which you can book a flight from Missouri to Panama City (average of $478). Flying from Missouri to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Missouri to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$373	Average$575	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$397	Average$596	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$410	Average$587	FlexibilityNo cancel fee	On-time71%

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$164+ Cheap flights from Missouri to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/18. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Missouri to Panama City

Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated August 14, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama CityExplore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City?

What is the cheapest time of day to fly from MO to PTY?

Find hourly flight availability from Missouri to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Panama City from Missouri?

What are the cheapest airlines to fly from Missouri to Panama City one-way?

What are the most popular routes from Missouri to Panama City?

Can I find deals for flights from Missouri to Panama City that include hotel bookings?

How can I find direct flights from Missouri to Panama City?

Can I find deals for business class flights from Missouri to Panama City?

What is the cheapest month to book a flight from Missouri to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Missouri to Panama City

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Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.