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Panama City

$319+ Cheap flights from Des Moines (DSM) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Aug 14 — Aug 211
Fri 8/14
Fri 8/21
1 adult, Economy
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Cheap flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 15, 2026.

This American Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:22 pm
DSM
-
PTY
2 stops18h 17m
American Airlines
Wed 9/91:16 pm
PTY
-
DSM
2 stops22h 48m
American Airlines
Deal found 7/11$664
This Delta deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/3111:28 am
DSM
-
PTY
1 stop25h 27m
Delta
Wed 9/92:23 pm
PTY
-
DSM
1 stop8h 06m
Delta
Deal found 7/11$666
This United Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am
DSM
-
PTY
1 stop12h 37m
United Airlines
Wed 10/1410:00 am
PTY
-
DSM
1 stop12h 15m
United Airlines
Deal found 7/12$673
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:54 pm
DSM
-
PTY
1 stop18h 02m
Delta
Wed 10/142:21 pm
PTY
-
DSM
1 stop8h 13m
Delta
Deal found 7/12$675
This United Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:55 pm
DSM
-
PTY
2 stops24h 36m
United Airlines
Thu 10/13:30 pm
PTY
-
DSM
2 stops21h 04m
United Airlines
Deal found 7/12$677
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:35 pm
DSM
-
PTY
2 stops17h 04m
American Airlines
Thu 9/31:39 pm
PTY
-
DSM
2 stops20h 21m
American Airlines
Deal found 7/13$678
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:54 pm
DSM
-
PTY
1 stop18h 02m
Delta
Thu 10/152:21 pm
PTY
-
DSM
2 stops30h 46m
Delta
Deal found 7/12$679
This American Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:10 pm
DSM
-
PTY
2 stops19h 29m
American Airlines
Tue 9/11:39 pm
PTY
-
DSM
2 stops20h 21m
American Airlines
Deal found 7/11$680
This Avianca deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2511:32 am
DSM
-
PTY
2 stops14h 23m
Multiple Airlines
Tue 9/15:30 am
PTY
-
DSM
2 stops17h 00m
Multiple Airlines
Deal found 7/11$684
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:40 am
DSM
-
PTY
1 stop7h 16m
Delta
Sat 10/172:21 pm
PTY
-
DSM
1 stop8h 13m
Delta
Deal found 7/12$689
This United Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:00 am
DSM
-
PTY
1 stop8h 14m
United Airlines
Mon 10/193:30 pm
PTY
-
DSM
2 stops22h 45m
United Airlines
Deal found 7/12$692

Find flight deals from Des Moines to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 15, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$664
(American Airlines)

One-way from

$319
(United Airlines)

Popular in

June

Cheapest in

February

Average price

$702
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
Search Deals
From Des Moines to Panama City Tocumen Intl
Search Deals
One-way flight from Des Moines to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 52% potential increase in price ($1,173 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 62% potential price decrease ($407 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 15, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 8/31

11:28 am-12:55 pm

1 stop25h 27m

Panama City Tocumen Intl

Wed 9/9

2:23 pm-10:29 pm

1 stop8h 06m

$666
Quickest round-trip

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 10/13

5:40 am-12:56 pm

1 stop7h 16m

Panama City Tocumen Intl

Wed 10/14

2:21 pm-10:34 pm

1 stop8h 13m

$675

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 10/7

6:00 am-7:31 pm

2 stops13h 31m

Panama City Tocumen Intl

Mon 10/19

3:30 pm-10:31 am

2 stops19h 01m

$677

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 9/14

5:56 pm-12:24 pm

2 stops18h 28m

Panama City Tocumen Intl

Fri 10/30

1:52 pm-1:30 pm

2 stops23h 38m

$677

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 9/27

6:55 pm-7:31 pm

2 stops24h 36m

Panama City Tocumen Intl

Thu 10/1

3:30 pm-12:34 pm

2 stops21h 04m

$677

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 10/12

6:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Thu 10/15

3:30 pm-10:31 am

2 stops19h 01m

$677

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 8/25

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Tue 9/1

10:00 am-10:30 pm

1 stop12h 30m

$679

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 9/1

8:00 am-7:31 pm

2 stops11h 31m

Panama City Tocumen Intl

Sun 9/6

10:00 am-8:24 pm

1 stop10h 24m

$688
Cheapest one-way

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 1/1

8:00 am-5:10 am

2 stops20h 10m

$319

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 8/29

4:13 pm-12:39 pm

2 stops20h 26m

$323

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/10

Showing 1-10 of 15 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Panama City in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

What is the cheapest month to book a flight from Des Moines to Panama City?

Currently, February is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $461). Flying from Des Moines to Panama City in June is currently the most expensive (average of $5,515). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated July 15, 2026.
See what other customers who have flown with United Airlines from Des Moines to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,988 reviews

Comfort

7.3

Boarding

7.7

Entertainment

7.1

Crew

8.1

Food

6.6

Overall

7.4

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this
United Airlines
7.4
Good
9,988 reviews
United Airlines
7.4
Good
9,988 reviews

Comfort

7.3

Boarding

7.7

Entertainment

7.1

Crew

8.1

Food

6.6

Overall

7.4

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Panama City?

    A quick flight from Des Moines to Panama City can take about 7h 15m. Delta provides one of the quickest options available for as low as $666. The distance from Des Moines to Panama City is about 2405 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Des Moines to Panama City round-trip?

    United Airlines, at $461, was found to be the cheapest airline from Des Moines to Panama City.. United Airlines is 56% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

  • Can I find deals for business class flights from Des Moines to Panama City?

    Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama City?

    Currently, February is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $461). Flying from Des Moines to Panama City in June is currently the most expensive (average of $5,515). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Des Moines to Panama City

Discover the top airline that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$461Average$524FlexibilityNo cancel feeOn-time69%

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