$607+ Cheap flights from Des Moines (DSM) to Panama City (PTY)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Oct 23 — Oct 301
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Panama City
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Best
Cheapest flights from Des Moines to Panama CityExplore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/88:00 am -
1 stop10h 38m
Tue 12/228:55 am -
1 stop14h 34m
Deal found 9/21![United Airlines logo]()
$607
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:45 pm -
2 stops23h 53m
Thu 4/17:55 am -
1 stop14h 35m
Deal found 9/22![United Airlines logo]()
$656
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:45 pm -
2 stops23h 53m
Mon 11/94:41 pm -
1 stop30h 49m
Deal found 9/18![United Airlines logo]()
$667
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1911:28 am -
2 stops26h 06m
Thu 11/263:34 pm -
2 stops20h 14m
Deal found 9/22![American Airlines logo]()
$675
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:45 pm -
2 stops24h 17m
Mon 11/304:41 pm -
2 stops18h 56m
Deal found 9/21![United Airlines logo]()
$683
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:00 am -
1 stop8h 13m
Thu 4/11:44 pm -
1 stop10h 12m
Deal found 9/18![American Airlines logo]()
$691
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:00 am -
1 stop8h 13m
Mon 11/93:13 pm -
1 stop9h 46m
Deal found 9/18![American Airlines logo]()
$730
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/198:00 am -
2 stops11h 02m
Thu 11/268:55 am -
1 stop30h 25m
Deal found 9/22![United Airlines logo]()
$851
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/58:00 am -
1 stop29h 45m
Thu 11/128:55 am -
1 stop14h 35m
Deal found 9/21![United Airlines logo]()
$852
Best flights from Des Moines to Panama CityDiscover carefully curated flight deals from Des Moines to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
Discover carefully curated flight deals from Des Moines to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/88:00 am -
1 stop10h 38m
Tue 12/228:55 am -
1 stop14h 34m
Deal found 9/21![United Airlines logo]()
$607
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/228:00 am -
1 stop10h 38m
Thu 1/284:41 pm -
2 stops22h 53m
Deal found 9/23![United Airlines logo]()
$645
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/176:30 pm -
2 stops21h 42m
Sat 1/234:41 pm -
2 stops22h 53m
Deal found 9/20![United Airlines logo]()
$645
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:45 pm -
2 stops23h 53m
Thu 4/13:30 pm -
2 stops20h 52m
Deal found 9/20![United Airlines logo]()
$656
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:45 pm -
2 stops19h 00m
Mon 11/94:41 pm -
2 stops18h 51m
Deal found 9/18![United Airlines logo]()
$656
Find flight deals from Des Moines to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $607 (United Airlines) |
Popular in | June |
Cheapest in | February |
Average price | $570 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 23, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesPanama City
DSM Des Moines - PTY Panama City Tocumen Intl
DSMPTY
Des Moines
Tue 12/8
8:00 am-7:38 pm
1 stop10h 38m
Panama City Tocumen Intl
Tue 12/22
8:55 am-10:29 pm
1 stop14h 34m
$607
Des MoinesPanama City
DSM Des Moines - PTY Panama City Tocumen Intl
DSMPTY
Des Moines
Fri 1/22
8:00 am-7:38 pm
1 stop10h 38m
Panama City Tocumen Intl
Thu 1/28
4:41 pm-2:34 pm
2 stops22h 53m
$645
Des MoinesPanama City
DSM Des Moines - PTY Panama City Tocumen Intl
DSMPTY
Des Moines
Sun 1/17
6:30 pm-5:12 pm
2 stops21h 42m
Panama City Tocumen Intl
Sat 1/23
4:41 pm-2:34 pm
2 stops22h 53m
$645
Des MoinesPanama City
DSM Des Moines - PTY Panama City Tocumen Intl
DSMPTY
Des Moines
Mon 11/2
6:45 pm-7:38 pm
2 stops23h 53m
Panama City Tocumen Intl
Thu 4/1
3:30 pm-12:22 pm
2 stops20h 52m
$656
Des MoinesPanama City
DSM Des Moines - PTY Panama City Tocumen Intl
DSMPTY
Des Moines
Mon 11/2
6:45 pm-2:45 pm
2 stops19h 00m
Panama City Tocumen Intl
Mon 11/9
4:41 pm-10:32 am
2 stops18h 51m
$656
Sorted by cheapest first
Compare providers for flights from Des Moines to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Panama City in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
DSM-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 23, 2026.
See what other customers who have flown with United Airlines from Des Moines to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.3
Boarding
7.7
Crew
8.1
Overall
7.4
Entertainment
7.1
Food
6.7
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Comfort
7.3
Boarding
7.7
Crew
8.1
Overall
7.4
Entertainment
7.1
Food
6.7
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Panama City flights
Browse other Des Moines and Panama City flight options. Last updated on September 23, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 23, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Des Moines to Panama City
Discover the top airline that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$461 | Average$571 | FlexibilityNo cancel fee | On-time69% |