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$309+ Cheap flights from Des Moines (DSM) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Jul 13 — Jul 201
Mon 7/13
Mon 7/20
1 adult, Economy
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Cheap flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2026.

This Avianca deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:15 pm
DSM
-
PTY
2 stops16h 35m
Multiple Airlines
Thu 11/269:45 am
PTY
-
DSM
2 stops15h 55m
Multiple Airlines
Deal found 6/12$665
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:20 am
DSM
-
PTY
1 stop9h 52m
United Airlines
Tue 8/410:00 am
PTY
-
DSM
1 stop12h 35m
United Airlines
Deal found 6/12$668
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:00 am
DSM
-
PTY
1 stop12h 37m
United Airlines
Thu 10/110:00 am
PTY
-
DSM
1 stop12h 15m
United Airlines
Deal found 6/11$673
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:15 am
DSM
-
PTY
1 stop12h 22m
United Airlines
Sat 9/1910:00 am
PTY
-
DSM
1 stop12h 30m
United Airlines
Deal found 6/9$678
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:44 am
DSM
-
PTY
1 stop7h 12m
Delta
Sat 9/192:21 pm
PTY
-
DSM
1 stop8h 08m
Delta
Deal found 6/10$679
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:00 am
DSM
-
PTY
2 stops22h 04m
United Airlines
Sat 6/2710:00 am
PTY
-
DSM
1 stop12h 35m
United Airlines
Deal found 6/13$683
This Kissandfly.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:20 am
DSM
-
PTY
1 stop12h 17m
Lufthansa
Thu 7/307:55 am
PTY
-
DSM
1 stop14h 40m
Lufthansa
Deal found 6/10$684
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:00 am
DSM
-
PTY
2 stops22h 04m
United Airlines
Thu 7/3010:55 pm
PTY
-
DSM
2 stops22h 27m
United Airlines
Deal found 6/11$687
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/173:02 pm
DSM
-
PTY
1 stop23h 12m
United Airlines
Thu 8/203:30 pm
PTY
-
DSM
1 stop22h 44m
United Airlines
Deal found 6/10$696

Find flight deals from Des Moines to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$665
(Avianca)

One-way from

$309
(Delta)

Popular in

June

Cheapest in

February

Average price

$5,515
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
Search Deals
From Des Moines to Panama City Tocumen Intl
Search Deals
One-way flight from Des Moines to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 53% potential increase in price ($1,192 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 65% potential price decrease ($408 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 9/29

6:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Thu 10/1

10:00 am-10:15 pm

1 stop12h 15m

$673

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 8/17

6:00 am-6:37 pm

2 stops12h 37m

Panama City Tocumen Intl

Thu 8/20

3:30 pm-12:18 pm

2 stops20h 48m

$677

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 9/16

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Sat 9/19

10:00 am-10:30 pm

1 stop12h 30m

$678
Cheapest one-way

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 7/24

6:37 pm-1:00 pm

1 stop18h 23m

$309

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 11/25

4:02 pm-1:36 pm

2 stops20h 34m

$309

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 12/1

5:26 pm-3:37 pm

2 stops21h 11m

$309

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 12/1

8:00 am-5:07 pm

1 stop8h 07m

$424
Quickest one-way

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 11/25

5:45 am-2:05 pm

1 stop7h 20m

$424

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/9

Sorted by cheapest first

Compare providers for flights from Des Moines to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Panama City in June.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

What is the cheapest month to book a flight from Des Moines to Panama City?

Currently, February is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $461). Flying from Des Moines to Panama City in June is currently the most expensive (average of $5,515). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated June 13, 2026.
See what other customers who have flown with United Airlines from Des Moines to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,815 reviews

Crew

8.1

Boarding

7.7

Entertainment

7.1

Overall

7.4

Food

6.6

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.
United Airlines
7.4
Good
9,815 reviews
United Airlines
7.4
Good
9,815 reviews

Crew

8.1

Boarding

7.7

Entertainment

7.1

Overall

7.4

Food

6.6

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Panama City?

    A quick flight from Des Moines to Panama City can take about 12h 37m. United Airlines provides one of the quickest options available for as low as $673. The distance from Des Moines to Panama City is about 2405 mi.

  • What is the cheapest airline to fly from Des Moines to Panama City round-trip?

    United Airlines, at $461, was found to be the cheapest airline from Des Moines to Panama City.. United Airlines is 55% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

  • Can I find deals for business class flights from Des Moines to Panama City?

    Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama City?

    Currently, February is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $461). Flying from Des Moines to Panama City in June is currently the most expensive (average of $5,515). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Des Moines to Panama City

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Top airline flying from Des Moines to Panama City

Discover the top airline that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$461Average$555FlexibilityNo cancel feeOn-time69%

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