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Panama City

$330+ Cheap flights from Des Moines (DSM) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Sep 3 — Sep 101
Thu 9/3
Thu 9/10
1 adult, Economy
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Cheap flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 4, 2026.

This Avianca deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:45 pm
DSM
-
PTY
2 stops14h 05m
Multiple Airlines
Thu 10/299:45 am
PTY
-
DSM
2 stops24h 41m
Multiple Airlines
Deal found 8/1$665
This Avianca deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/153:22 pm
DSM
-
PTY
2 stops17h 53m
Multiple Airlines
Tue 9/225:30 am
PTY
-
DSM
2 stops17h 00m
Multiple Airlines
Deal found 8/1$683
This United Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:45 pm
DSM
-
PTY
2 stops24h 17m
United Airlines
Thu 10/297:55 am
PTY
-
DSM
1 stop14h 35m
United Airlines
Deal found 8/1$697
This American Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/189:27 am
DSM
-
PTY
2 stops27h 49m
American Airlines
Thu 11/263:15 pm
PTY
-
DSM
1 stop9h 34m
American Airlines
Deal found 8/4$702
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:56 pm
DSM
-
PTY
2 stops18h 20m
American Airlines
Thu 9/241:16 pm
PTY
-
DSM
2 stops19h 23m
American Airlines
Deal found 8/3$707
This United Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:15 am
DSM
-
PTY
1 stop12h 22m
United Airlines
Wed 9/2310:00 am
PTY
-
DSM
1 stop12h 30m
United Airlines
Deal found 8/1$713

Find flight deals from Des Moines to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$665
(Avianca)

One-way from

$330
(American Airlines)

Popular in

June

Cheapest in

February

Average price

$547
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
Search Deals
From Des Moines to Panama City Tocumen Intl
Search Deals
One-way flight from Des Moines to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 52% potential increase in price ($1,173 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 62% potential price decrease ($407 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 9/15

3:22 pm-9:15 am

2 stops17h 53m

Panama City Tocumen Intl

Tue 9/22

5:30 am-10:30 pm

2 stops17h 00m

$683

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 1/11

8:00 am-7:38 pm

1 stop10h 38m

Panama City Tocumen Intl

Tue 1/19

8:55 am-10:30 pm

1 stop14h 35m

$693

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 1/11

3:59 pm-3:38 pm

2 stops22h 39m

Panama City Tocumen Intl

Tue 1/19

4:46 pm-1:30 pm

2 stops21h 44m

$697

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 1/31

6:45 pm-2:45 pm

2 stops19h 00m

Panama City Tocumen Intl

Mon 2/8

8:55 am-10:30 pm

1 stop14h 35m

$697

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 11/18

9:27 am-2:16 pm

2 stops27h 49m

Panama City Tocumen Intl

Thu 11/26

3:15 pm-11:49 pm

1 stop9h 34m

$702

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 9/16

8:00 am-6:37 pm

2 stops10h 37m

Panama City Tocumen Intl

Wed 9/23

9:45 am-10:30 am

2 stops24h 45m

$717

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 9/17

2:13 pm-12:16 pm

2 stops22h 03m

Panama City Tocumen Intl

Thu 9/24

1:16 pm-1:43 pm

2 stops24h 27m

$721

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 10/25

5:35 am-12:59 pm

1 stop7h 24m

Panama City Tocumen Intl

Thu 10/29

2:24 pm-10:33 pm

1 stop8h 09m

$723
Quickest round-trip

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 9/15

5:45 am-12:58 pm

1 stop7h 13m

Panama City Tocumen Intl

Tue 9/22

2:23 pm-10:26 pm

1 stop8h 03m

$733
Cheapest one-way

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 9/15

2:13 pm-12:26 pm

2 stops22h 13m

$330

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/1

Showing 1-10 of 11 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Panama City in August.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

What is the cheapest month to book a flight from Des Moines to Panama City?

Currently, February is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $461). Flying from Des Moines to Panama City in June is currently the most expensive (average of $5,515). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated August 4, 2026.
See what other customers who have flown with United Airlines from Des Moines to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
10,059 reviews

Overall

7.4

Food

6.6

Boarding

7.7

Crew

8.1

Entertainment

7.1

Comfort

7.3

Reviews

1 / 20
2.0
Mediocre

Dawn,Aug 2026

ORD - DEN

I missed my connecting flight because our plane took off ten minutes late and then when we got to the airport another plane was in our shoot waiting to get fueled up and that took 30 minutes so I missed my connecting flight. I asked if I could get off and they assured me the plane would most likely wait for me since they know what time the planes get in because of an app. I was not happy. I had to wait till 7:25 to board the next flight and then that was delayed. Gates changed till 9:20. Terrible
United Airlines
7.4
Good
10,059 reviews
United Airlines
7.4
Good
10,059 reviews

Overall

7.4

Food

6.6

Boarding

7.7

Crew

8.1

Entertainment

7.1

Comfort

7.3

Reviews

1 / 20
2.0
Mediocre

Dawn,Aug 2026

ORD - DEN

I missed my connecting flight because our plane took off ten minutes late and then when we got to the airport another plane was in our shoot waiting to get fueled up and that took 30 minutes so I missed my connecting flight. I asked if I could get off and they assured me the plane would most likely wait for me since they know what time the planes get in because of an app. I was not happy. I had to wait till 7:25 to board the next flight and then that was delayed. Gates changed till 9:20. Terrible

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Panama City?

    A quick flight from Des Moines to Panama City can take about 10h 38m. United Airlines provides one of the quickest options available for as low as $693. The distance from Des Moines to Panama City is about 2405 mi.

  • What is the cheapest airline to fly from Des Moines to Panama City round-trip?

    United Airlines, at $461, was found to be the cheapest airline from Des Moines to Panama City.. United Airlines is 56% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

  • Can I find deals for business class flights from Des Moines to Panama City?

    Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama City?

    Currently, February is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $461). Flying from Des Moines to Panama City in June is currently the most expensive (average of $5,515). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Des Moines to Panama City

Discover the top airline that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$461Average$524FlexibilityNo cancel feeOn-time69%

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