Panama City

$275+ Cheap flights from Iowa to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/17. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
feb. 28 — mar. 71
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Cheap flight deals from Iowa to Panama City

Cheapest flights from Iowa to Panama City
Explore the most affordable flight options available from Iowa to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 29, 2026.

This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/267:52 am
DSM
-
PTY
1 stop8h 15m
United Airlines
sáb. 3/78:55 am
PTY
-
DSM
1 stop14h 49m
United Airlines
Deal found 1/28$483
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/247:52 am
DSM
-
PTY
1 stop10h 46m
United Airlines
vie. 3/611:55 pm
PTY
-
DSM
2 stops19h 13m
United Airlines
Deal found 1/28$487
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 2/98:10 am
DSM
-
PTY
1 stop7h 57m
United Airlines
vie. 2/134:41 pm
PTY
-
DSM
1 stop30h 34m
United Airlines
Deal found 1/26$492
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 4/228:20 am
DSM
-
PTY
1 stop7h 52m
United Airlines
dom. 4/263:30 pm
PTY
-
DSM
2 stops20h 59m
United Airlines
Deal found 1/27$519
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 4/265:00 pm
DSM
-
PTY
2 stops19h 36m
American Airlines
dom. 5/31:49 pm
PTY
-
DSM
2 stops21h 39m
American Airlines
Deal found 1/27$524
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 4/86:15 am
OMA
-
PTY
1 stop9h 57m
United Airlines
lun. 4/1310:00 am
PTY
-
OMA
1 stop12h 28m
United Airlines
Deal found 1/28$543
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/276:00 am
OMA
-
PTY
2 stops12h 37m
United Airlines
lun. 6/13:30 pm
PTY
-
OMA
2 stops21h 14m
United Airlines
Deal found 1/28$547
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 3/315:24 pm
CID
-
PTY
2 stops20h 50m
United Airlines
mar. 4/710:55 pm
PTY
-
CID
2 stops13h 52m
United Airlines
Deal found 1/28$547
This KAYAK deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/152:58 pm
DSM
-
PTY
1 stop25h 14m
Copa Airlines
jue. 5/213:30 pm
PTY
-
DSM
2 stops29h 42m
Copa Airlines
Deal found 1/28$547
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 5/252:54 pm
OMA
-
PTY
1 stop27h 43m
United Airlines
mar. 6/23:20 pm
PTY
-
OMA
2 stops21h 10m
United Airlines
Deal found 1/27$557
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/167:44 pm
DSM
-
PTY
2 stops18h 36m
American Airlines
lun. 3/231:40 pm
PTY
-
DSM
2 stops19h 21m
American Airlines
Deal found 1/27$562
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 4/186:15 am
OMA
-
PTY
1 stop9h 57m
United Airlines
mié. 4/2210:00 am
PTY
-
OMA
1 stop12h 28m
United Airlines
Deal found 1/28$563

Find flight deals from Iowa to Panama City

Keep the following information in mind while searching for Iowa to Panama City flight deals. Data was last updated enero 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$483
(United Airlines)

One-way from

$275
(United Airlines)

Popular in

December

Cheapest in

September

Average price

$453
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
From Iowa to Panama City Tocumen Intl
One-way flight from Iowa to Panama City Tocumen Intl
Highest demand for flights based on searches. 16% potential increase in price ($117 potential increase over avg. RT price).
Cheapest flight prices on average. 7% potential price decrease ($42 potential savings vs. average RT price).
Average for round-trip flights in January 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 29, 2026.
Use the filters below to find and compare flights from Iowa to Panama City that are best for you.

Fly from

Iowa

Fly to

Panama City

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

jue. 2/26

7:52 am-5:07 pm

1 stop8h 15m

Panama City Tocumen Intl

mar. 3/3

8:55 am-10:20 pm

1 stop14h 25m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

lun. 4/27

8:20 am-4:12 pm

1 stop7h 52m

Panama City Tocumen Intl

lun. 5/4

10:00 am-10:45 pm

1 stop12h 45m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

jue. 2/26

7:52 am-7:38 pm

1 stop10h 46m

Panama City Tocumen Intl

sáb. 3/7

8:55 am-10:44 pm

1 stop14h 49m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

mar. 2/24

7:52 am-7:38 pm

1 stop10h 46m

Panama City Tocumen Intl

vie. 3/6

8:55 am-10:44 pm

1 stop14h 49m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

lun. 2/9

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

vie. 2/13

4:41 pm-2:27 pm

2 stops22h 46m

$487

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

lun. 2/9

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

mié. 2/25

4:41 pm-2:27 pm

2 stops22h 46m

$487

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

mié. 4/8

6:15 am-4:12 pm

1 stop9h 57m

Panama City Tocumen Intl

lun. 4/13

10:00 am-10:28 pm

1 stop12h 28m

$543

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

lun. 5/25

8:00 am-4:12 pm

1 stop8h 12m

Panama City Tocumen Intl

mar. 6/2

7:55 am-7:19 pm

1 stop11h 24m

$543

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

mar. 5/26

5:10 pm-12:10 pm

2 stops19h 00m

Panama City Tocumen Intl

mar. 6/2

1:10 pm-11:27 am

2 stops22h 17m

$547

OmahaPanama City

OMA - PTY

OMAPTY

Omaha Eppley Airfield

mar. 5/26

5:23 pm-4:12 pm

2 stops22h 49m

Panama City Tocumen Intl

mar. 6/2

7:55 am-7:19 pm

1 stop11h 24m

$547

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 29 results
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Best time to book a flight from Iowa to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Panama City

What is the cheapest month to book a flight from Iowa to Panama City?

Currently, April is the cheapest month in which you can book a flight from Iowa to Panama City (average of $411). Flying from Iowa to Panama City in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly into for flights to Panama City from Iowa?

    Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly into when you book flights from Iowa to Panama City.

  • How long is the flight from Iowa to Panama City?

    Departing from Iowa to Panama City will take you 8h 15m. Airlines will cover a distance of 2405 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Iowa to Panama City?

  • Can I find deals for flights from Iowa to Panama City that include hotel bookings?

    Yes. In addition to deals on Iowa to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Panama City.

  • Can I find deals for business class flights from Iowa to Panama City?

    Yes. Cheapflights offers flight deals from Iowa to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Panama City?

    Currently, April is the cheapest month in which you can book a flight from Iowa to Panama City (average of $411). Flying from Iowa to Panama City in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Iowa to Panama City

Discover the top 2 airlines that operate flights from Iowa to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$435Average$481FlexibilityNo cancel feeOn-time69%
DeltaCheapest$441Average$573FlexibilityNo cancel feeOn-timeN/A

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