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Des Moines

$244+ Cheap flights from Charleston to Des Moines (CHS - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Aug 11 — Aug 181
Tue 8/11
Tue 8/18
1 adult, Economy
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Cheap flight deals from Charleston to Des Moines

Cheapest flights from Charleston to Des Moines
Explore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 12, 2026.

This American Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:50 pm
CHS
-
DSM
1 stop5h 30m
American Airlines
Thu 8/134:13 pm
DSM
-
CHS
1 stop5h 37m
American Airlines
Deal found 7/9$263
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/54:04 pm
CHS
-
DSM
2 stops30h 27m
Multiple Airlines
Mon 8/106:07 pm
DSM
-
CHS
1 stop23h 07m
Multiple Airlines
Deal found 7/11$335
This United Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/144:38 pm
CHS
-
DSM
1 stop5h 45m
United Airlines
Mon 8/176:00 am
DSM
-
CHS
2 stops8h 10m
United Airlines
Deal found 7/9$338
This United Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:00 pm
CHS
-
DSM
1 stop5h 35m
United Airlines
Mon 11/21:05 pm
DSM
-
CHS
1 stop7h 14m
United Airlines
Deal found 7/7$343
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/36:17 pm
CHS
-
DSM
1 stop6h 52m
American Airlines
Thu 8/61:55 pm
DSM
-
CHS
1 stop7h 23m
American Airlines
Deal found 7/7$345
This Kiwi.com deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:00 am
CHS
-
DSM
2 stops31h 59m
Multiple Airlines
Mon 8/106:07 pm
DSM
-
CHS
1 stop23h 07m
Multiple Airlines
Deal found 7/11$362
This United Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:00 am
CHS
-
DSM
1 stop5h 17m
United Airlines
Thu 8/136:00 am
DSM
-
CHS
2 stops8h 10m
United Airlines
Deal found 7/8$384

Find flight deals from Charleston to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$263
(American Airlines)

One-way from

$244
(United Airlines)

Popular in

June

Cheapest in

April

Average price

$514
Provider with most accurate pricing for Charleston-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Des Moines flights.
Search Deals
From Charleston to Des Moines
Search Deals
One-way flight from Charleston to Des Moines
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($79 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 12, 2026.
Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 10/29

9:54 am-8:29 pm

2 stops11h 35m

Des Moines

Mon 11/2

3:15 pm-9:19 pm

1 stop5h 04m

$348

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Mon 8/3

5:55 pm-11:35 pm

1 stop6h 40m

Des Moines

Thu 8/6

5:40 am-3:25 pm

2 stops8h 45m

$396

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Mon 8/3

1:00 pm-8:18 pm

2 stops8h 18m

Des Moines

Thu 8/6

1:55 pm-10:18 pm

1 stop7h 23m

$406
Quickest round-trip

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 12/31

3:19 pm-9:17 pm

1 stop6h 58m

Des Moines

Sun 1/3

5:00 am-10:27 am

1 stop4h 27m

$407
Cheapest one-way

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Mon 7/27

4:16 pm-11:44 pm

1 stop8h 28m

$244

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Sat 11/28

5:10 am-1:15 pm

1 stop9h 05m

$244

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Mon 7/27

12:00 pm-11:35 pm

2 stops12h 35m

$249

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Sun 8/2

3:25 pm-11:50 pm

2 stops9h 25m

$326

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Mon 7/27

9:31 pm-12:59 pm

3 stops40h 28m

$404
Quickest one-way

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Sun 11/29

7:35 am-11:15 am

1 stop4h 40m

$409

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/11

Showing 1-10 of 12 resultsSorted by cheapest first
1
2

Compare providers for flights from Charleston to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Des Moines in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Charleston-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Charleston-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Charleston to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Des Moines

What is the cheapest month to book a flight from Charleston to Des Moines?

Currently, April is the cheapest month in which you can book a flight from Charleston to Des Moines (average of $316). Flying from Charleston to Des Moines in August is currently the most expensive (average of $692). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated July 12, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Charleston to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.8
Good
8,458 reviews

Comfort

7.8

Entertainment

7.8

Overall

7.8

Crew

8.5

Food

7.2

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
Delta
7.8
Good
8,458 reviews
Delta
7.8
Good
8,458 reviews

Comfort

7.8

Entertainment

7.8

Overall

7.8

Crew

8.5

Food

7.2

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
American Airlines
7.1
Good
11,804 reviews
Delta
7.8
Good
8,458 reviews

Comfort

7.8

Entertainment

7.8

Overall

7.8

Crew

8.5

Food

7.2

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Related info for your journey

Find useful and relevant information for your journey from Charleston to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Charleston to Des Moines?

    For as low as $348, United Airlines can have you in Des Moines from Charleston in 5h 18m. The distance between Charleston and Des Moines is about 956 mi.

  • What are the cheapest airlines flying from Charleston to Des Moines round-trip?

    Currently priced at $140, American Airlines will fly you from Charleston to Des Moines and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $238. American Airlines is 66% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Charleston to Des Moines that include hotel bookings?

    Yes. In addition to deals on Charleston to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Des Moines.

  • Can I find deals for business class flights from Charleston to Des Moines?

    Yes. Cheapflights offers flight deals from Charleston to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Des Moines?

    Currently, April is the cheapest month in which you can book a flight from Charleston to Des Moines (average of $316). Flying from Charleston to Des Moines in August is currently the most expensive (average of $692). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Ames
Clive
Johnston
Boone
West Des Moines
Ankeny

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Top 2 airlines flying from Charleston to Des Moines

Discover the top 2 airlines that operate flights from Charleston to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$140Average$342FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$514FlexibilityNo cancel feeOn-timeN/A

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