$127+ Cheap flights from Charleston to Des Moines (CHS - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Dec 2 — Dec 91
Round-trip
1 adult, Economy
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Find cheap flights from Charleston to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Charleston to Des Moines
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Cheapest flights from Charleston to Des MoinesExplore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2026.
Explore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2026.
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:35 pm -
1 stop4h 55m
Thu 12/1011:38 am -
1 stop7h 05m
Deal found 10/29![American Airlines logo]()
$281
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/224:31 pm -
1 stop7h 07m
Wed 12/236:43 pm -
1 stop4h 11m
Deal found 10/28![Delta logo]()
$399
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:00 am -
1 stop8h 35m
Sat 11/289:25 am -
1 stop4h 52m
Deal found 10/29![American Airlines logo]()
$409
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:00 pm -
1 stop21h 56m
Sat 11/149:00 am -
1 stop22h 38m
Deal found 10/29![Multiple Airlines logo]()
$430
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/243:40 pm -
1 stop8h 28m
Sun 12/273:26 pm -
1 stop7h 54m
Deal found 10/30![American Airlines logo]()
$431
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:25 am -
2 stops9h 50m
Sat 11/286:45 am -
1 stop12h 45m
Deal found 10/29![Southwest logo]()
$450
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/134:16 pm -
1 stop7h 19m
Tue 11/175:30 am -
1 stop6h 22m
Deal found 10/29![Delta logo]()
$537
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:16 pm -
2 stops8h 23m
Tue 11/1711:09 am -
1 stop6h 37m
Deal found 10/29![American Airlines logo]()
$542
Best flights from Charleston to Des MoinesDiscover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 2, 2026.
Discover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 2, 2026.
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:35 pm -
1 stop4h 55m
Thu 12/1011:38 am -
1 stop7h 05m
Deal found 11/1![American Airlines logo]()
$325
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/224:31 pm -
1 stop7h 07m
Wed 12/236:43 pm -
1 stop4h 11m
Deal found 10/28![Delta logo]()
$399
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/44:00 pm -
2 stops8h 05m
Thu 1/146:55 am -
2 stops11h 15m
Deal found 10/28![Southwest logo]()
$417
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/99:46 am -
1 stop5h 44m
Wed 1/136:15 am -
1 stop6h 31m
Deal found 11/1![United Airlines logo]()
$425
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/243:40 pm -
1 stop8h 28m
Sun 12/273:26 pm -
1 stop7h 54m
Deal found 10/30![American Airlines logo]()
$431
Last-minute flights from Charleston to Des MoinesDiscover last-minute flight deals from Charleston to Des Moines. Data last updated November 2, 2026 and is based on user searches.
Discover last-minute flight deals from Charleston to Des Moines. Data last updated November 2, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:44 am -
1 stop10h 57m
Sat 10/316:05 am -
1 stop11h 24m
Deal found 10/28![American Airlines logo]()
$997
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:28 pm -
2 stops9h 31m
Sat 10/316:05 am -
2 stops12h 07m
Deal found 10/28![United Airlines logo]()
$1,047
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:00 pm -
1 stop21h 56m
Sat 11/149:00 am -
1 stop22h 38m
Deal found 10/29![Multiple Airlines logo]()
$430
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1012:03 pm -
2 stops7h 53m
Sat 11/149:25 am -
2 stops6h 33m
Deal found 10/29![American Airlines logo]()
$703
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/134:16 pm -
1 stop7h 19m
Tue 11/175:30 am -
1 stop6h 22m
Deal found 10/29![Delta logo]()
$537
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:16 pm -
2 stops8h 23m
Tue 11/1711:09 am -
1 stop6h 37m
Deal found 10/29![American Airlines logo]()
$542
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/134:00 pm -
2 stops8h 05m
Tue 11/177:00 am -
2 stops9h 25m
Deal found 10/29![Southwest logo]()
$547
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:00 am -
1 stop8h 35m
Sat 11/289:25 am -
1 stop4h 52m
Deal found 10/29![American Airlines logo]()
$409
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/268:25 am -
2 stops9h 50m
Sat 11/286:45 am -
1 stop12h 45m
Deal found 10/29![Southwest logo]()
$450
One-way flights from Charleston to Des MoinesSearch for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated November 2, 2026.
Search for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated November 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:14 pm -
1 stop8h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Multiple Airlines logo]()
$127
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:10 am -
1 stop5h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$141
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/188:30 am -
2 stops8h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![United Airlines logo]()
$146
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/57:01 am -
1 stop5h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Delta logo]()
$163
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/277:05 am -
1 stop4h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Delta logo]()
$190
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/53:23 pm -
2 stops8h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![United Airlines logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/203:14 pm -
1 stop7h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:45 am -
2 stops40h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Multiple Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:00 am -
3 stops40h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$248
Find flight deals from Charleston to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $281 (American Airlines) |
One-way from | $127 (Kiwi.com) |
Popular in | January |
Cheapest in | April |
Average price | $541 |
Cheapflights Fare Finder
Customize your flight search to find flights from Charleston to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 2, 2026.
Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Fri 11/13
3:14 pm-10:15 pm
1 stop8h 01m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$127
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Wed 11/18
8:30 am-4:07 pm
2 stops8h 37m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$146
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Tue 1/5
7:01 am-11:01 am
1 stop5h 00m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$163
Quickest round-trip
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Fri 11/27
7:05 am-10:44 am
1 stop4h 39m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$190
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Tue 1/5
3:23 pm-11:14 pm
2 stops8h 51m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$218
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Wed 11/18
6:00 am-9:18 pm
3 stops40h 18m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$248
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Thu 11/12
2:13 pm-2:36 pm
2 stops25h 23m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$265
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Thu 11/12
4:15 pm-11:42 pm
1 stop8h 27m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$269
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Thu 11/12
5:34 pm-10:35 pm
1 stop6h 01m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$269
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Fri 11/13
3:16 pm-10:39 pm
2 stops8h 23m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$274
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Charleston to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Des Moines in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Charleston-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Charleston-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Charleston to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Charleston with our price prediction graph.
CHS-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Charleston to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated November 2, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Charleston to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Boarding
8.1
Overall
7.8
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Crew
8.5
Boarding
8.1
Overall
7.8
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Crew
8.5
Boarding
8.1
Overall
7.8
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Charleston to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 2, 2026.
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Charleston and Des Moines flights
Browse other Charleston and Des Moines flight options. Last updated on November 2, 2026.
Other flights from Charleston
Browse through other flights departing from Charleston. Flights are based on user searches made on Cheapflights and were last updated on November 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Charleston to Des Moines
Discover the top 2 airlines that operate flights from Charleston to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$233 | Average$354 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$502 | FlexibilityNo cancel fee | On-timeN/A |