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Des Moines

$110+ Cheap flights from Charleston to Des Moines (CHS - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Charleston to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$275
(Kiwi.com)

One-way from

$110
(American Airlines)

Popular in

February

Cheapest in

October

Average price

$366
From Charleston to Des Moines
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One-way flight from Charleston to Des Moines
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Highest demand for flights based on searches. 20% potential increase in price ($120 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($28 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Charleston to Des Moines

Cheapest flights from Charleston to Des Moines
Explore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2812:08 pmCHS - DSM
2 stops26h 24mMultiple Airlines
Thu 10/210:41 amDSM - CHS
1 stop21h 24mMultiple Airlines
Deal found 9/13$305
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:09 pmCHS - DSM
1 stop5h 53mAmerican Airlines
Sun 11/95:00 amDSM - CHS
1 stop8h 26mAmerican Airlines
Deal found 9/13$326
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/232:59 pmCHS - DSM
1 stop19h 25mMultiple Airlines
Fri 9/2610:37 amDSM - CHS
1 stop27h 47mMultiple Airlines
Deal found 9/13$334
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/76:15 amCHS - DSM
2 stops5h 45mSouthwest
Sun 11/98:00 amDSM - CHS
1 stop6h 10mSouthwest
Deal found 9/13$348
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/186:08 pmCHS - DSM
1 stop21h 32mMultiple Airlines
Sun 9/216:30 amDSM - CHS
2 stops12h 43mMultiple Airlines
Deal found 9/12$393
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:15 amCHS - DSM
2 stops17h 14mMultiple Airlines
Mon 9/298:25 amDSM - CHS
1 stop7h 42mMultiple Airlines
Deal found 9/14$424
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/288:17 pmCHS - DSM
1 stop4h 58mAmerican Airlines
Thu 10/23:50 pmDSM - CHS
1 stop5h 11mAmerican Airlines
Deal found 9/13$447
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/77:45 pmCHS - DSM
2 stops21h 28mUnited Airlines
Sun 11/98:02 amDSM - CHS
1 stop4h 53mUnited Airlines
Deal found 9/14$529

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.

Fly from

Charleston

Fly to

Des Moines

Route

Depart

Return

Price

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Sun 9/28

12:08 pm-1:32 pm

2 stops26h 24m

Des Moines

Thu 10/2

10:41 am-9:05 am

1 stop21h 24m

$305

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 11/7

5:09 pm-10:02 pm

1 stop5h 53m

Des Moines

Sun 11/9

5:00 am-2:26 pm

1 stop8h 26m

$326

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Tue 9/23

2:59 pm-9:24 am

1 stop19h 25m

Des Moines

Fri 9/26

10:37 am-3:24 pm

1 stop27h 47m

$334

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 11/7

6:15 am-11:00 am

2 stops5h 45m

Des Moines

Sun 11/9

8:00 am-3:10 pm

1 stop6h 10m

$348

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 9/18

6:08 pm-2:40 pm

1 stop21h 32m

Des Moines

Sun 9/21

6:30 am-8:13 pm

2 stops12h 43m

$393

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 9/26

6:15 am-10:29 pm

2 stops17h 14m

Des Moines

Mon 9/29

8:25 am-5:07 pm

1 stop7h 42m

$424

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Sun 9/28

8:17 pm-12:15 am

1 stop4h 58m

Des Moines

Thu 10/2

3:50 pm-10:01 pm

1 stop5h 11m

$447

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 11/7

7:45 pm-4:13 pm

2 stops21h 28m

Des Moines

Sun 11/9

8:02 am-1:55 pm

1 stop4h 53m

$529

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Tue 10/7

7:30 am-1:18 pm

1 stop6h 48m

$110

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Tue 10/7

11:29 am-4:52 pm

1 stop6h 23m

$149

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/12

Showing 1-10 of 16 results
1
2

Best time to book a flight from Charleston to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Des Moines

What is the cheapest month to book a flight from Charleston to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Charleston to Des Moines (average of $336). Flying from Charleston to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to DSM?

Find hourly flight availability from Charleston to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Charleston to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 16% versus a flight at noon.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 15, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Charleston to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Charleston to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Charleston to Des Moines?

    For as low as $348, American Airlines can have you in Des Moines from Charleston in 5h 45m. The distance between Charleston and Des Moines is about 956 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Charleston to Des Moines round-trip?

    Currently priced at $236, Delta will fly you from Charleston to Des Moines and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $262. Delta is 47% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Charleston to Des Moines that include hotel bookings?

    Yes. In addition to deals on Charleston to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Des Moines.

  • Can I find deals for business class flights from Charleston to Des Moines?

    Yes. Cheapflights offers flight deals from Charleston to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Charleston to Des Moines (average of $336). Flying from Charleston to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for Charleston to Des Moines

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Top 2 airlines flying from Charleston to Des Moines

Discover the top 2 airlines that operate flights from Charleston to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$236Average$372FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$262Average$441FlexibilityNo cancel feeOn-time71%

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