$159+ Cheap flights from Charleston to Des Moines (CHS - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/19. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Jul 27 — Aug 31
Round-trip
1 adult, Economy
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Find cheap flights from Charleston to Des Moines with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
Last-minute
One-way
Cheapest flights from Charleston to Des MoinesExplore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 27, 2026.
Explore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 27, 2026.
This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:06 pm
CHS
- DSM
1 stop5h 35m
American Airlines
Thu 8/138:10 am
DSM
- CHS
1 stop4h 06m
American Airlines
Deal found 6/26![American Airlines logo]()
$323
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:10 am
CHS
- DSM
1 stop6h 33m
Delta
Thu 8/1310:23 am
DSM
- CHS
1 stop6h 35m
Delta
Deal found 6/23![Delta logo]()
$355
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/288:56 am
CHS
- DSM
1 stop5h 09m
American Airlines
Fri 7/311:41 pm
DSM
- CHS
1 stop4h 36m
American Airlines
Deal found 6/24![American Airlines logo]()
$362
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/283:00 pm
CHS
- DSM
2 stops8h 50m
Southwest
Fri 7/314:40 pm
DSM
- CHS
1 stop5h 15m
Southwest
Deal found 6/24![Southwest logo]()
$367
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:50 pm
CHS
- DSM
1 stop5h 45m
United Airlines
Mon 10/193:11 pm
DSM
- CHS
1 stop5h 22m
United Airlines
Deal found 6/23![United Airlines logo]()
$381
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:25 pm
CHS
- DSM
1 stop5h 05m
Southwest
Mon 10/195:35 am
DSM
- CHS
2 stops8h 00m
Southwest
Deal found 6/23![Southwest logo]()
$386
This United Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:00 pm
CHS
- DSM
1 stop7h 02m
United Airlines
Wed 11/181:05 pm
DSM
- CHS
1 stop7h 14m
United Airlines
Deal found 6/22![United Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/318:21 pm
CHS
- DSM
1 stop4h 40m
American Airlines
Mon 8/31:35 pm
DSM
- CHS
1 stop5h 16m
American Airlines
Deal found 6/26![American Airlines logo]()
$407
This United Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:19 am
CHS
- DSM
2 stops8h 38m
United Airlines
Mon 9/143:22 pm
DSM
- CHS
1 stop6h 47m
United Airlines
Deal found 6/27![United Airlines logo]()
$408
Best flights from Charleston to Des MoinesDiscover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 27, 2026.
Discover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 27, 2026.
This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:06 pm
CHS
- DSM
1 stop5h 35m
American Airlines
Thu 8/138:10 am
DSM
- CHS
1 stop4h 06m
American Airlines
Deal found 6/26![American Airlines logo]()
$323
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:45 pm
CHS
- DSM
1 stop4h 52m
Delta
Thu 8/1310:23 am
DSM
- CHS
1 stop6h 35m
Delta
Deal found 6/22![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/283:00 pm
CHS
- DSM
2 stops8h 50m
Southwest
Fri 7/314:40 pm
DSM
- CHS
1 stop5h 15m
Southwest
Deal found 6/24![Southwest logo]()
$367
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:50 pm
CHS
- DSM
1 stop5h 45m
United Airlines
Mon 10/193:11 pm
DSM
- CHS
1 stop5h 22m
United Airlines
Deal found 6/23![United Airlines logo]()
$381
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:25 pm
CHS
- DSM
1 stop6h 27m
American Airlines
Mon 9/141:30 pm
DSM
- CHS
1 stop4h 26m
American Airlines
Deal found 6/27![American Airlines logo]()
$323
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/51:25 pm
CHS
- DSM
2 stops9h 30m
Southwest
Fri 8/75:40 am
DSM
- CHS
2 stops8h 45m
Southwest
Deal found 6/25![Southwest logo]()
$372
This United Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:44 pm
CHS
- DSM
1 stop5h 18m
United Airlines
Wed 11/182:56 pm
DSM
- CHS
1 stop5h 59m
United Airlines
Deal found 6/26![United Airlines logo]()
$397
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:15 pm
CHS
- DSM
2 stops9h 15m
Southwest
Mon 10/195:35 am
DSM
- CHS
2 stops8h 00m
Southwest
Deal found 6/23![Southwest logo]()
$392
Last-minute flights from Charleston to Des MoinesDiscover last-minute flight deals from Charleston to Des Moines. Data last updated June 27, 2026 and is based on user searches.
Discover last-minute flight deals from Charleston to Des Moines. Data last updated June 27, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/27:47 pm
CHS
- DSM
1 stop21h 03m
Multiple Airlines
Sun 7/53:59 pm
DSM
- CHS
2 stops51h 50m
Multiple Airlines
Deal found 6/26![Multiple Airlines logo]()
$746
This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:05 am
CHS
- DSM
1 stop6h 29m
American Airlines
Sun 7/56:12 am
DSM
- CHS
1 stop5h 17m
American Airlines
Deal found 6/26![American Airlines logo]()
$777
This United Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:00 am
CHS
- DSM
2 stops11h 15m
United Airlines
Sun 7/56:20 am
DSM
- CHS
1 stop8h 42m
United Airlines
Deal found 6/26![United Airlines logo]()
$782
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/248:00 am
CHS
- DSM
1 stop4h 30m
Southwest
Sun 7/264:15 pm
DSM
- CHS
1 stop5h 40m
Southwest
Deal found 6/25![Southwest logo]()
$417
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/288:56 am
CHS
- DSM
1 stop5h 09m
American Airlines
Fri 7/311:41 pm
DSM
- CHS
1 stop4h 36m
American Airlines
Deal found 6/24![American Airlines logo]()
$362
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/283:00 pm
CHS
- DSM
2 stops8h 50m
Southwest
Fri 7/314:40 pm
DSM
- CHS
1 stop5h 15m
Southwest
Deal found 6/24![Southwest logo]()
$367
This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/318:21 pm
CHS
- DSM
1 stop4h 40m
American Airlines
Mon 8/31:35 pm
DSM
- CHS
1 stop5h 16m
American Airlines
Deal found 6/26![American Airlines logo]()
$407
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/313:23 pm
CHS
- DSM
1 stop25h 46m
Multiple Airlines
Mon 8/35:30 pm
DSM
- CHS
2 stops14h 08m
Multiple Airlines
Deal found 6/26![Multiple Airlines logo]()
$495
This Southwest deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/314:45 pm
CHS
- DSM
2 stops7h 50m
Southwest
Mon 8/35:10 am
DSM
- CHS
2 stops11h 10m
Southwest
Deal found 6/26![Southwest logo]()
$502
One-way flights from Charleston to Des MoinesSearch for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 27, 2026.
Search for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 27, 2026.
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/194:08 pm
CHS
- DSM
1 stop8h 36m
American Airlines
Deal found 6/25![American Airlines logo]()
$159
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:00 am
CHS
- DSM
2 stops8h 16m
United Airlines
Deal found 6/23![United Airlines logo]()
$164
This American Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:06 pm
CHS
- DSM
1 stop5h 35m
American Airlines
Deal found 6/23![American Airlines logo]()
$178
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2011:30 am
CHS
- DSM
2 stops10h 45m
Southwest
Deal found 6/23![Southwest logo]()
$183
This Kiwi.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/109:44 pm
CHS
- DSM
1 stop24h 59m
Multiple Airlines
Deal found 6/24![Multiple Airlines logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:00 am
CHS
- DSM
2 stops18h 07m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$197
This United Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:00 am
CHS
- DSM
1 stop5h 17m
United Airlines
Deal found 6/22![United Airlines logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/113:55 pm
CHS
- DSM
2 stops8h 36m
Allegiant Air
Deal found 6/26![Allegiant Air logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/113:55 pm
CHS
- DSM
3 stops31h 03m
Multiple Airlines
Deal found 6/26![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:00 am
CHS
- DSM
2 stops16h 58m
Multiple Airlines
Deal found 6/26![Multiple Airlines logo]()
$243
This Delta deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/113:11 pm
CHS
- DSM
1 stop6h 57m
Delta
Deal found 6/26![Delta logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:56 pm
CHS
- DSM
3 stops23h 58m
Multiple Airlines
Deal found 6/23![Multiple Airlines logo]()
$258
Find flight deals from Charleston to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $323 (American Airlines) |
One-way from | $159 (American Airlines) |
Popular in | August |
Cheapest in | April |
Average price | $618 |
Cheapflights Fare Finder
Customize your flight search to find flights from Charleston to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 27, 2026.
Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Thu 8/6
2:06 pm-6:41 pm
1 stop5h 35m
Des Moines
Thu 8/13
8:10 am-1:16 pm
1 stop4h 06m
$323
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Thu 9/10
6:25 pm-11:52 pm
1 stop6h 27m
Des Moines
Mon 9/14
1:30 pm-6:56 pm
1 stop4h 26m
$323
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Thu 8/6
6:45 pm-10:37 pm
1 stop4h 52m
Des Moines
Thu 8/13
10:23 am-5:58 pm
1 stop6h 35m
$355
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Tue 7/28
3:00 pm-10:50 pm
2 stops8h 50m
Des Moines
Fri 7/31
4:40 pm-10:55 pm
1 stop5h 15m
$367
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Wed 8/5
1:25 pm-9:55 pm
2 stops9h 30m
Des Moines
Fri 8/7
5:40 am-3:25 pm
2 stops8h 45m
$372
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Fri 10/16
6:50 pm-11:35 pm
1 stop5h 45m
Des Moines
Mon 10/19
3:11 pm-9:33 pm
1 stop5h 22m
$381
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Fri 10/16
3:15 pm-11:30 pm
2 stops9h 15m
Des Moines
Mon 10/19
5:35 am-2:35 pm
2 stops8h 00m
$392
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Tue 11/17
6:44 pm-11:02 pm
1 stop5h 18m
Des Moines
Wed 11/18
2:56 pm-9:55 pm
1 stop5h 59m
$397
Cheapest one-way
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Wed 8/19
4:08 pm-11:44 pm
1 stop8h 36m
$159
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Wed 8/19
7:00 am-2:16 pm
2 stops8h 16m
$164
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Charleston to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Des Moines in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Charleston-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Charleston-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Charleston to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Charleston with our price prediction graph.
CHS-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Charleston to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated June 27, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Charleston to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Charleston to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Ames
Clive
Johnston
Boone
West Des Moines
Ankeny
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Charleston to Des Moines
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 27, 2026.
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Charleston and Des Moines flights
Browse other Charleston and Des Moines flight options. Last updated on June 27, 2026.
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Top 2 airlines flying from Charleston to Des Moines
Discover the top 2 airlines that operate flights from Charleston to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$140 | Average$370 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$502 | FlexibilityNo cancel fee | On-timeN/A |