$163+ Cheap flights from Charleston to Des Moines (CHS - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/5. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Nov 18 — Nov 251
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Charleston to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Charleston to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Charleston to Des MoinesExplore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
Explore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:14 pm -
1 stop7h 54m
Mon 11/28:30 am -
2 stops23h 08m
Deal found 10/19![Multiple Airlines logo]()
$333
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:14 pm -
1 stop7h 54m
Wed 11/412:46 pm -
1 stop18h 52m
Deal found 10/19![Multiple Airlines logo]()
$370
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:13 pm -
1 stop19h 12m
Mon 11/28:30 am -
2 stops23h 08m
Deal found 10/19![Multiple Airlines logo]()
$384
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/188:00 am -
1 stop4h 25m
Fri 11/205:25 am -
1 stop9h 25m
Deal found 10/19![Southwest logo]()
$393
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/63:14 pm -
1 stop8h 01m
Fri 11/138:30 pm -
2 stops40h 07m
Deal found 10/16![Multiple Airlines logo]()
$394
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:05 am -
1 stop6h 43m
Fri 11/133:31 pm -
1 stop5h 55m
Deal found 10/16![American Airlines logo]()
$395
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:13 pm -
1 stop19h 12m
Wed 11/412:46 pm -
1 stop18h 52m
Deal found 10/19![Multiple Airlines logo]()
$421
Best flights from Charleston to Des MoinesDiscover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
Discover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:35 am -
2 stops8h 40m
Fri 11/205:25 am -
1 stop9h 25m
Deal found 10/19![Southwest logo]()
$399
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/104:17 pm -
1 stop7h 18m
Thu 11/126:52 pm -
1 stop4h 07m
Deal found 10/19![Delta logo]()
$457
This American Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/286:56 pm -
1 stop6h 00m
Sun 4/47:14 am -
1 stop7h 29m
Deal found 10/17![American Airlines logo]()
$467
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:39 pm -
1 stop5h 38m
Thu 12/248:00 am -
1 stop5h 00m
Deal found 10/16![United Airlines logo]()
$556
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:43 pm -
1 stop5h 50m
Mon 11/26:55 am -
1 stop6h 33m
Deal found 10/15![Delta logo]()
$537
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/304:45 pm -
2 stops7h 30m
Mon 11/25:25 am -
2 stops12h 05m
Deal found 10/15![Southwest logo]()
$553
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:39 pm -
1 stop5h 38m
Fri 12/259:32 am -
1 stop7h 18m
Deal found 10/16![United Airlines logo]()
$556
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/254:55 pm -
2 stops7h 40m
Mon 11/305:10 am -
2 stops9h 50m
Deal found 10/18![Southwest logo]()
$590
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:12 am -
2 stops11h 43m
Thu 11/128:00 am -
2 stops8h 39m
Deal found 10/16![United Airlines logo]()
$621
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/193:20 pm -
2 stops8h 40m
Sun 12/275:10 am -
2 stops9h 50m
Deal found 10/16![Southwest logo]()
$641
Last-minute flights from Charleston to Des MoinesDiscover last-minute flight deals from Charleston to Des Moines. Data last updated October 19, 2026 and is based on user searches.
Discover last-minute flight deals from Charleston to Des Moines. Data last updated October 19, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:13 pm -
1 stop19h 12m
Mon 11/28:30 am -
2 stops23h 08m
Deal found 10/19![Multiple Airlines logo]()
$384
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:13 pm -
1 stop19h 12m
Wed 11/412:46 pm -
1 stop18h 52m
Deal found 10/19![Multiple Airlines logo]()
$421
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:14 pm -
1 stop7h 54m
Mon 11/28:30 am -
2 stops23h 08m
Deal found 10/19![Multiple Airlines logo]()
$333
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:14 pm -
1 stop7h 54m
Wed 11/412:46 pm -
1 stop18h 52m
Deal found 10/19![Multiple Airlines logo]()
$370
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/63:14 pm -
1 stop8h 01m
Fri 11/138:30 pm -
2 stops40h 07m
Deal found 10/16![Multiple Airlines logo]()
$394
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:05 am -
1 stop6h 43m
Fri 11/133:31 pm -
1 stop5h 55m
Deal found 10/16![American Airlines logo]()
$395
This Southwest deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/188:00 am -
1 stop4h 25m
Fri 11/205:25 am -
1 stop9h 25m
Deal found 10/19![Southwest logo]()
$393
One-way flights from Charleston to Des MoinesSearch for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
Search for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/57:00 am -
1 stop4h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Delta logo]()
$163
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/57:00 am -
2 stops8h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![American Airlines logo]()
$214
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/53:23 pm -
2 stops8h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![United Airlines logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/129:18 pm -
3 stops37h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$284
This Delta deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:23 pm -
1 stop4h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Delta logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/262:13 pm -
3 stops24h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:00 am -
3 stops16h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/17![Multiple Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:34 pm -
2 stops8h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![American Airlines logo]()
$435
Find flight deals from Charleston to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $333 (Kiwi.com) |
One-way from | $163 (Delta) |
Popular in | June |
Cheapest in | April |
Average price | $418 |
Cheapflights Fare Finder
Customize your flight search to find flights from Charleston to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 19, 2026.
Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Tue 1/5
7:00 am-10:18 am
1 stop4h 18m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$163
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Tue 1/5
7:00 am-2:56 pm
2 stops8h 56m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$214
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Tue 1/5
3:23 pm-11:14 pm
2 stops8h 51m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$218
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Tue 11/24
7:00 pm-10:59 pm
1 stop4h 59m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$219
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Wed 11/18
3:23 pm-7:15 pm
1 stop4h 52m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$296
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Wed 11/18
6:35 am-2:15 pm
2 stops8h 40m
Des Moines
Fri 11/20
5:25 am-3:50 pm
1 stop9h 25m
$399
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Tue 11/10
4:17 pm-10:35 pm
1 stop7h 18m
Des Moines
Thu 11/12
6:52 pm-11:59 pm
1 stop4h 07m
$457
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Sun 3/28
6:56 pm-11:56 pm
1 stop6h 00m
Des Moines
Sun 4/4
7:14 am-3:43 pm
1 stop7h 29m
$467
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Fri 10/30
5:43 pm-10:33 pm
1 stop5h 50m
Des Moines
Mon 11/2
6:55 am-2:28 pm
1 stop6h 33m
$537
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Fri 10/30
4:45 pm-11:15 pm
2 stops7h 30m
Des Moines
Mon 11/2
5:25 am-6:30 pm
2 stops12h 05m
$553
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Charleston to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Des Moines in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Charleston-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Charleston-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Charleston to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Charleston with our price prediction graph.
CHS-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Charleston to Des Moines
What is the cheapest month to book a flight from Charleston to Des Moines?
Currently, April is the cheapest month in which you can book a flight from Charleston to Des Moines (average of $316). Flying from Charleston to Des Moines in June is currently the most expensive (average of $618). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Charleston to Des Moines?
Airfare is below average for this route at the moment.
Charleston to Des Moines flights typically cost between $396 and $442 in October.The cheapest round-trip price found within the last 5 days was $333 on Multiple Airlines (Oct 30-Nov 2).
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 19, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Charleston to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Food
7.2
Comfort
7.8
Boarding
8.1
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Overall
7.8
Food
7.2
Comfort
7.8
Boarding
8.1
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Overall
7.8
Food
7.2
Comfort
7.8
Boarding
8.1
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Charleston to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Des Moines flight routes
Flights by cabin class
Other flight options
Other flights from Charleston
Popular flights
Alternative routes for Charleston to Des Moines
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 19, 2026.
Search flights from Charleston to Des Moines by cabin class
Find flights from Charleston to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Charleston and Des Moines flights
Browse other Charleston and Des Moines flight options. Last updated on October 19, 2026.
Other flights from Charleston
Browse through other flights departing from Charleston. Flights are based on user searches made on Cheapflights and were last updated on October 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Charleston to Des Moines
Discover the top 2 airlines that operate flights from Charleston to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$233 | Average$349 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$442 | FlexibilityNo cancel fee | On-timeN/A |