$149+ Cheap flights from Charleston to Des Moines (CHS - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/22. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Jul 4 — Jul 111
Round-trip
1 adult, Economy
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Find cheap flights from Charleston to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Charleston to Des Moines
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Best
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Cheapest flights from Charleston to Des MoinesExplore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 4, 2026.
Explore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 4, 2026.
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:43 pm
CHS
- DSM
1 stop5h 01m
American Airlines
Thu 8/201:08 pm
DSM
- CHS
1 stop4h 40m
American Airlines
Deal found 5/31![American Airlines logo]()
$297
This United Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/14:30 pm
CHS
- DSM
1 stop8h 14m
United Airlines
Wed 9/26:00 am
DSM
- CHS
1 stop6h 58m
United Airlines
Deal found 6/1![United Airlines logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:47 pm
CHS
- DSM
1 stop21h 03m
Multiple Airlines
Mon 7/274:40 pm
DSM
- CHS
1 stop24h 34m
Multiple Airlines
Deal found 5/30![Multiple Airlines logo]()
$316
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:10 am
CHS
- DSM
1 stop6h 20m
Southwest
Sun 7/54:15 pm
DSM
- CHS
1 stop5h 40m
Southwest
Deal found 5/31![Southwest logo]()
$381
This Southwest deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/234:45 pm
CHS
- DSM
2 stops7h 50m
Southwest
Mon 7/275:10 am
DSM
- CHS
2 stops6h 30m
Southwest
Deal found 5/30![Southwest logo]()
$417
Best flights from Charleston to Des MoinesDiscover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 4, 2026.
Discover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 4, 2026.
This United Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/14:30 pm
CHS
- DSM
1 stop8h 14m
United Airlines
Wed 9/26:00 am
DSM
- CHS
1 stop6h 58m
United Airlines
Deal found 6/1![United Airlines logo]()
$313
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:41 am
CHS
- DSM
1 stop7h 15m
American Airlines
Thu 7/161:41 pm
DSM
- CHS
1 stop7h 22m
American Airlines
Deal found 6/2![American Airlines logo]()
$381
Last-minute flights from Charleston to Des MoinesDiscover last-minute flight deals from Charleston to Des Moines. Data last updated June 4, 2026 and is based on user searches.
Discover last-minute flight deals from Charleston to Des Moines. Data last updated June 4, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1612:58 pm
CHS
- DSM
1 stop6h 24m
American Airlines
Tue 6/231:51 pm
DSM
- CHS
1 stop4h 39m
American Airlines
Deal found 5/31![American Airlines logo]()
$421
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/163:00 pm
CHS
- DSM
2 stops8h 45m
Southwest
Tue 6/235:20 am
DSM
- CHS
2 stops7h 10m
Southwest
Deal found 5/31![Southwest logo]()
$432
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/167:47 pm
CHS
- DSM
1 stop5h 03m
American Airlines
Fri 6/191:37 pm
DSM
- CHS
1 stop7h 28m
American Airlines
Deal found 6/2![American Airlines logo]()
$487
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/255:55 pm
CHS
- DSM
1 stop6h 35m
Southwest
Sun 6/284:15 pm
DSM
- CHS
1 stop5h 35m
Southwest
Deal found 5/31![Southwest logo]()
$427
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:10 am
CHS
- DSM
1 stop6h 20m
Southwest
Sun 7/54:15 pm
DSM
- CHS
1 stop5h 40m
Southwest
Deal found 5/31![Southwest logo]()
$381
This Kiwi.com deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:47 pm
CHS
- DSM
1 stop21h 03m
Multiple Airlines
Mon 7/274:40 pm
DSM
- CHS
1 stop24h 34m
Multiple Airlines
Deal found 5/30![Multiple Airlines logo]()
$316
This Southwest deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/234:45 pm
CHS
- DSM
2 stops7h 50m
Southwest
Mon 7/275:10 am
DSM
- CHS
2 stops6h 30m
Southwest
Deal found 5/30![Southwest logo]()
$417
One-way flights from Charleston to Des MoinesSearch for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 4, 2026.
Search for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 4, 2026.
This Delta deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:41 pm
CHS
- DSM
1 stop4h 56m
Delta
Deal found 5/29![Delta logo]()
$149
This United Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:45 am
CHS
- DSM
2 stops9h 31m
United Airlines
Deal found 5/29![United Airlines logo]()
$154
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/237:47 pm
CHS
- DSM
1 stop5h 03m
American Airlines
Deal found 6/1![American Airlines logo]()
$178
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/256:00 am
CHS
- DSM
2 stops17h 58m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$183
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/231:50 pm
CHS
- DSM
2 stops9h 55m
Southwest
Deal found 6/1![Southwest logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/128:20 pm
CHS
- DSM
1 stop26h 55m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$195
This United Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:00 am
CHS
- DSM
1 stop5h 17m
United Airlines
Deal found 6/2![United Airlines logo]()
$204
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/304:45 pm
CHS
- DSM
2 stops7h 50m
Southwest
Deal found 6/2![Southwest logo]()
$209
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/267:29 am
CHS
- DSM
1 stop6h 52m
American Airlines
Deal found 6/3![American Airlines logo]()
$214
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/271:35 pm
CHS
- DSM
2 stops6h 59m
American Airlines
Deal found 6/3![American Airlines logo]()
$219
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/314:45 pm
CHS
- DSM
2 stops7h 50m
Southwest
Deal found 6/1![Southwest logo]()
$229
Find flight deals from Charleston to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $297 (American Airlines) |
One-way from | $149 (Delta) |
Popular in | November |
Cheapest in | April |
Average price | $502 |
Cheapflights Fare Finder
Customize your flight search to find flights from Charleston to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 4, 2026.
Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Tue 9/1
4:30 pm-11:44 pm
1 stop8h 14m
Des Moines
Wed 9/2
6:00 am-1:58 pm
1 stop6h 58m
$313
Quickest round-trip
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Tue 7/14
6:41 am-12:56 pm
1 stop7h 15m
Des Moines
Thu 7/16
1:41 pm-10:03 pm
1 stop7h 22m
$381
Cheapest one-way
Quickest one-way
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Sat 8/22
6:41 pm-10:37 pm
1 stop4h 56m
$149
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Sat 8/22
5:45 am-2:16 pm
2 stops9h 31m
$154
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Tue 6/23
1:50 pm-10:45 pm
2 stops9h 55m
$189
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Sun 7/12
8:20 pm-10:15 pm
1 stop26h 55m
$195
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Thu 7/30
6:00 am-10:17 am
1 stop5h 17m
$204
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Thu 6/25
7:47 pm-11:50 pm
1 stop5h 03m
$214
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Fri 7/31
4:45 pm-11:35 pm
2 stops7h 50m
$229
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Sat 8/22
3:44 pm-2:22 pm
3 stops23h 38m
$246
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Charleston to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Des Moines in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Charleston-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Charleston-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Charleston to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Charleston with our price prediction graph.
CHS-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Charleston to Des Moines
What is the cheapest month to book a flight from Charleston to Des Moines?
Currently, April is the cheapest month in which you can book a flight from Charleston to Des Moines (average of $316). Flying from Charleston to Des Moines in November is currently the most expensive (average of $537). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Charleston to Des Moines?
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated June 4, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Charleston to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Overall
7.9
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Overall
7.9
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Overall
7.9
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Charleston to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny
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Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 4, 2026.
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Find flights from Charleston to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Charleston and Des Moines flights
Browse other Charleston and Des Moines flight options. Last updated on June 4, 2026.
Other flights from Charleston
Browse through other flights departing from Charleston. Flights are based on user searches made on Cheapflights and were last updated on June 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Charleston to Des Moines
Discover the top 2 airlines that operate flights from Charleston to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$140 | Average$370 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$478 | FlexibilityNo cancel fee | On-timeN/A |