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Des Moines

$157+ Cheap flights from Charleston to Des Moines (CHS - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/18. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Charleston to Des Moines

Cheapest flights from Charleston to Des Moines
Explore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:13 pmCHS - DSM
1 stop19h 42mMultiple Airlines
Mon 11/246:40 amDSM - CHS
1 stop9h 38mMultiple Airlines
Deal found 10/30$203
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:30 amCHS - DSM
1 stop5h 08mDelta
Tue 12/2310:29 amDSM - CHS
1 stop4h 42mDelta
Deal found 10/29$334
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2112:51 pmCHS - DSM
1 stop5h 55mDelta
Mon 11/247:46 amDSM - CHS
1 stop8h 32mDelta
Deal found 10/28$344
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1812:17 pmCHS - DSM
1 stop6h 48mAmerican Airlines
Tue 12/232:07 pmDSM - CHS
1 stop7h 04mAmerican Airlines
Deal found 10/30$348
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/215:10 amCHS - DSM
2 stops8h 26mAmerican Airlines
Mon 11/246:00 amDSM - CHS
1 stop6h 23mAmerican Airlines
Deal found 10/28$349
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:44 amCHS - DSM
1 stop7h 37mAmerican Airlines
Mon 12/223:28 pmDSM - CHS
1 stop5h 58mAmerican Airlines
Deal found 10/29$366

Cheap flight deals from Charleston to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$203
(Kiwi.com)

One-way from

$157
(Delta)

Popular in

February

Cheapest in

January

Average price

$392
Provider with most accurate pricing for Charleston-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Des Moines flights.
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From Charleston to Des Moines
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One-way flight from Charleston to Des Moines
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($112 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($30 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.

Fly from

Charleston

Fly to

Des Moines

Route

Depart

Return

Price

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 11/20

6:13 pm-12:55 pm

1 stop19h 42m

Des Moines

Mon 11/24

6:40 am-5:18 pm

1 stop9h 38m

$203

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 12/18

6:30 am-10:38 am

1 stop5h 08m

Des Moines

Tue 12/23

10:29 am-4:11 pm

1 stop4h 42m

$334

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 11/21

12:51 pm-5:46 pm

1 stop5h 55m

Des Moines

Mon 11/24

7:46 am-5:18 pm

1 stop8h 32m

$344

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 12/18

12:17 pm-6:05 pm

1 stop6h 48m

Des Moines

Tue 12/23

2:07 pm-10:11 pm

1 stop7h 04m

$348

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 11/21

5:10 am-12:36 pm

2 stops8h 26m

Des Moines

Mon 11/24

6:00 am-1:23 pm

1 stop6h 23m

$349

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 12/18

6:44 am-3:24 pm

2 stops9h 40m

Des Moines

Mon 12/22

3:28 pm-10:26 pm

1 stop5h 58m

$424

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 12/18

6:44 am-1:21 pm

1 stop7h 37m

$157

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 12/18

12:51 pm-5:47 pm

1 stop5h 56m

$157

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Tue 11/4

6:11 pm-10:00 am

2 stops40h 49m

$331

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Tue 11/4

6:15 am-10:30 am

1 stop5h 15m

$369

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 11 results
1
2

Compare providers for flights from Charleston to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Des Moines in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Charleston-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Charleston-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Charleston-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Charleston-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Charleston to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Des Moines

What is the cheapest month to book a flight from Charleston to Des Moines?

Currently, September is the cheapest month in which you can book a flight from Charleston to Des Moines (average of $162). Flying from Charleston to Des Moines in December is currently the most expensive (average of $428). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to DSM?

Find hourly flight availability from Charleston to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

When flying from Charleston to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 15% versus a flight at noon.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 30, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Charleston to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Charleston to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Charleston to Des Moines?

    For as low as $334, Delta can have you in Des Moines from Charleston in 5h 08m. The distance between Charleston and Des Moines is about 956 mi.

  • What are the cheapest airlines flying from Charleston to Des Moines round-trip?

    Currently priced at $236, Delta will fly you from Charleston to Des Moines and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $262. Delta is 46% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Charleston to Des Moines that include hotel bookings?

    Yes. In addition to deals on Charleston to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Des Moines.

  • Can I find deals for business class flights from Charleston to Des Moines?

    Yes. Cheapflights offers flight deals from Charleston to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from Charleston to Des Moines (average of $162). Flying from Charleston to Des Moines in December is currently the most expensive (average of $428). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Top 2 airlines flying from Charleston to Des Moines

Discover the top 2 airlines that operate flights from Charleston to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$236Average$418FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$262Average$466FlexibilityNo cancel feeOn-time71%

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