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Des Moines

$167+ Cheap flights from Charleston to Des Moines (CHS - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/16. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
May 22 — May 291
Fri 5/22
Fri 5/29
1 adult, Economy
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Cheap flight deals from Charleston to Des Moines

Cheapest flights from Charleston to Des Moines
Explore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2026.

This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:47 am
CHS
-
DSM
1 stop6h 19m
Delta
Tue 5/196:15 am
DSM
-
CHS
1 stop5h 04m
Delta
Deal found 4/21$316
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:46 pm
CHS
-
DSM
1 stop6h 32m
American Airlines
Tue 5/198:56 am
DSM
-
CHS
1 stop8h 06m
American Airlines
Deal found 4/21$332
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1012:10 pm
CHS
-
DSM
1 stop9h 33m
American Airlines
Wed 6/246:30 am
DSM
-
CHS
1 stop5h 59m
American Airlines
Deal found 4/20$335
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:35 am
CHS
-
DSM
2 stops8h 19m
American Airlines
Tue 5/191:38 pm
DSM
-
CHS
1 stop7h 08m
American Airlines
Deal found 4/17$340
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:55 am
CHS
-
DSM
1 stop6h 10m
United Airlines
Wed 9/23:00 pm
DSM
-
CHS
1 stop6h 13m
United Airlines
Deal found 4/20$343
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:50 pm
CHS
-
DSM
2 stops9h 55m
Southwest
Thu 6/114:40 pm
DSM
-
CHS
1 stop5h 10m
Southwest
Deal found 4/21$347
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/134:55 pm
CHS
-
DSM
1 stop6h 37m
Delta
Mon 5/186:41 pm
DSM
-
CHS
1 stop4h 18m
Delta
Deal found 4/21$366
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:15 am
CHS
-
DSM
1 stop5h 10m
Southwest
Mon 5/185:25 am
DSM
-
CHS
2 stops10h 40m
Southwest
Deal found 4/21$373

Find flight deals from Charleston to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$316
(Delta)

One-way from

$167
(American Airlines)

Popular in

November

Cheapest in

April

Average price

$316
Provider with most accurate pricing for Charleston-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Des Moines flights.
Search Deals
From Charleston to Des Moines
Search Deals
One-way flight from Charleston to Des Moines
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($86 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 5/15

4:46 pm-10:18 pm

1 stop6h 32m

Des Moines

Tue 5/19

8:56 am-6:02 pm

1 stop8h 06m

$332

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 5/13

6:35 am-1:54 pm

2 stops8h 19m

Des Moines

Tue 5/19

1:38 pm-9:46 pm

1 stop7h 08m

$340

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 5/15

2:15 pm-11:05 pm

2 stops9h 50m

Des Moines

Tue 5/19

3:15 pm-9:05 pm

1 stop4h 50m

$375

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 5/13

7:15 am-11:25 am

1 stop5h 10m

Des Moines

Mon 5/18

5:25 am-5:05 pm

2 stops10h 40m

$392

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 5/13

5:00 am-11:30 am

2 stops7h 30m

Des Moines

Mon 5/18

2:18 pm-11:06 pm

1 stop7h 48m

$402

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Fri 6/12

5:55 pm-11:30 pm

1 stop6h 35m

Des Moines

Sun 6/14

4:15 pm-10:50 pm

1 stop5h 35m

$407

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 6/3

6:40 am-2:05 pm

2 stops8h 25m

Des Moines

Wed 6/10

3:45 pm-9:25 pm

1 stop4h 40m

$412
Quickest round-trip

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 5/7

7:40 am-11:45 am

1 stop5h 05m

Des Moines

Mon 5/11

4:20 pm-9:55 pm

1 stop4h 35m

$432
Cheapest one-way

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Sat 6/27

7:10 pm-11:59 pm

1 stop5h 49m

$204

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Sat 6/27

6:50 am-2:20 pm

1 stop8h 30m

$204

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/17

Showing 1-10 of 15 resultsSorted by cheapest first
1
2

Compare providers for flights from Charleston to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Des Moines in April.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Charleston-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Charleston-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Charleston to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Des Moines

What is the cheapest month to book a flight from Charleston to Des Moines?

Currently, April is the cheapest month in which you can book a flight from Charleston to Des Moines (average of $316). Flying from Charleston to Des Moines in November is currently the most expensive (average of $537). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Charleston to Des Moines?

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 22, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Charleston to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,430 reviews

Entertainment

7.8

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,430 reviews
Delta
7.9
Good
8,430 reviews

Entertainment

7.8

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,647 reviews
Delta
7.9
Good
8,430 reviews

Entertainment

7.8

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.2

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Charleston to Des Moines?

    For as low as $332, American Airlines can have you in Des Moines from Charleston in 6h 32m. The distance between Charleston and Des Moines is about 956 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Charleston to Des Moines round-trip?

    Currently priced at $233, American Airlines will fly you from Charleston to Des Moines and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $236. American Airlines is 39% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Charleston to Des Moines that include hotel bookings?

    Yes. In addition to deals on Charleston to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Des Moines.

  • Can I find deals for business class flights from Charleston to Des Moines?

    Yes. Cheapflights offers flight deals from Charleston to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Des Moines?

    Currently, April is the cheapest month in which you can book a flight from Charleston to Des Moines (average of $316). Flying from Charleston to Des Moines in November is currently the most expensive (average of $537). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny

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Top 2 airlines flying from Charleston to Des Moines

Discover the top 2 airlines that operate flights from Charleston to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$233Average$342FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$418FlexibilityNo cancel feeOn-timeN/A

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