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Des Moines

$153+ Cheap flights from Charleston to Des Moines (CHS - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/18. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
dic. 31 — ene. 71
mié. 12/31
mié. 1/7
1 adult, Economy
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Find flight deals from Charleston to Des Moines

Cheapest flights from Charleston to Des Moines
Explore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 1, 2025.

This United Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/2111:40 amCHS - DSM
1 stop7h 25mUnited Airlines
mar. 12/2311:35 amDSM - CHS
1 stop6h 43mUnited Airlines
Deal found 11/30$407
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/2112:15 pmCHS - DSM
1 stop5h 54mAmerican Airlines
mar. 12/233:55 pmDSM - CHS
2 stops7h 10mAmerican Airlines
Deal found 11/30$412
This Southwest deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/211:55 pmCHS - DSM
2 stops10h 15mSouthwest
mar. 12/235:30 amDSM - CHS
2 stops12h 50mSouthwest
Deal found 11/30$433
This Kiwi.com deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/159:49 pmCHS - DSM
2 stops37h 52mMultiple Airlines
vie. 12/196:35 amDSM - CHS
1 stop5h 35mMultiple Airlines
Deal found 11/30$454
This Delta deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/156:31 pmCHS - DSM
1 stop5h 03mDelta
vie. 12/192:16 pmDSM - CHS
1 stop6h 48mDelta
Deal found 11/30$467
This United Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/156:05 amCHS - DSM
2 stops11h 07mUnited Airlines
vie. 12/198:00 amDSM - CHS
2 stops10h 04mUnited Airlines
Deal found 11/30$501
This Delta deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/112:28 pmCHS - DSM
1 stop4h 19mDelta
lun. 12/1511:23 amDSM - CHS
1 stop6h 58mDelta
Deal found 11/29$542
This Southwest deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/2211:15 amCHS - DSM
2 stops12h 55mSouthwest
vie. 12/265:30 amDSM - CHS
2 stops9h 25mSouthwest
Deal found 12/1$548
This Southwest deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/88:25 amCHS - DSM
2 stops12h 30mSouthwest
lun. 12/156:15 amDSM - CHS
2 stops9h 50mSouthwest
Deal found 12/1$552
This United Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/264:59 pmCHS - DSM
1 stop5h 41mUnited Airlines
lun. 12/296:46 pmDSM - CHS
1 stop14h 49mUnited Airlines
Deal found 11/28$567
This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/86:00 amCHS - DSM
2 stops9h 20mUnited Airlines
lun. 12/158:00 amDSM - CHS
1 stop4h 55mUnited Airlines
Deal found 12/1$582
This American Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/266:44 amCHS - DSM
2 stops9h 09mAmerican Airlines
lun. 12/291:25 pmDSM - CHS
1 stop9h 32mAmerican Airlines
Deal found 11/28$616

Cheap flight deals from Charleston to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated diciembre 1, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$297
(Kiwi.com)

One-way from

$153
(Kiwi.com)

Popular in

February

Cheapest in

January

Average price

$449
Provider with most accurate pricing for Charleston-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Des Moines flights.
Search Deals
From Charleston to Des Moines
Search Deals
One-way flight from Charleston to Des Moines
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($123 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($31 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 1, 2025.
Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.

Fly from

Charleston

Fly to

Des Moines

Route

Depart

Return

Price

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

jue. 2/19

7:00 am-11:12 pm

2 stops17h 12m

Des Moines

dom. 2/22

3:32 pm-5:30 pm

1 stop24h 58m

$297

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

jue. 2/19

5:07 pm-10:20 pm

1 stop6h 13m

Des Moines

dom. 2/22

8:00 am-1:52 pm

1 stop4h 52m

$350

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

jue. 2/19

10:55 am-9:20 pm

2 stops11h 25m

Des Moines

dom. 2/22

6:10 am-6:45 pm

2 stops11h 35m

$360

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

vie. 1/2

6:44 am-1:21 pm

1 stop7h 37m

Des Moines

dom. 1/4

6:52 pm-3:18 am

1 stop7h 26m

$407

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

dom. 12/21

11:40 am-6:05 pm

1 stop7h 25m

Des Moines

mar. 12/23

11:35 am-7:18 pm

1 stop6h 43m

$407

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

dom. 12/21

12:15 pm-5:09 pm

1 stop5h 54m

Des Moines

mar. 12/23

3:55 pm-12:05 am

2 stops7h 10m

$412

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

dom. 12/21

1:55 pm-11:10 pm

2 stops10h 15m

Des Moines

mar. 12/23

5:30 am-7:20 pm

2 stops12h 50m

$433

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

lun. 12/15

9:49 pm-10:41 am

2 stops37h 52m

Des Moines

vie. 12/19

6:35 am-1:10 pm

1 stop5h 35m

$454

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

lun. 12/15

6:31 pm-10:34 pm

1 stop5h 03m

Des Moines

vie. 12/19

2:16 pm-10:04 pm

1 stop6h 48m

$467

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

jue. 12/18

3:08 pm-9:09 pm

2 stops31h 01m

$153

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/1

Showing 1-10 of 15 results
1
2

Compare providers for flights from Charleston to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Des Moines in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Charleston-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Charleston-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Charleston-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Charleston-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Charleston to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Des Moines

What is the cheapest month to book a flight from Charleston to Des Moines?

Currently, September is the cheapest month in which you can book a flight from Charleston to Des Moines (average of $162). Flying from Charleston to Des Moines in February is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to DSM?

Find hourly flight availability from Charleston to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 1, 2025.

When flying from Charleston to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 15% versus a flight at noon.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated diciembre 1, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Charleston to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,012 reviews

Crew

8.5

Entertainment

7.9

Overall

7.9

Food

7.3

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,012 reviews
Delta
7.9
Good
8,012 reviews

Crew

8.5

Entertainment

7.9

Overall

7.9

Food

7.3

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,039 reviews
Delta
7.9
Good
8,012 reviews

Crew

8.5

Entertainment

7.9

Overall

7.9

Food

7.3

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Charleston to Des Moines?

    For as low as $350, United Airlines can have you in Des Moines from Charleston in 6h 13m. The distance between Charleston and Des Moines is about 956 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Charleston to Des Moines round-trip?

    Currently priced at $233, American Airlines will fly you from Charleston to Des Moines and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $236. American Airlines is 45% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Charleston to Des Moines that include hotel bookings?

    Yes. In addition to deals on Charleston to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Des Moines.

  • Can I find deals for business class flights from Charleston to Des Moines?

    Yes. Cheapflights offers flight deals from Charleston to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from Charleston to Des Moines (average of $162). Flying from Charleston to Des Moines in February is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Top 2 airlines flying from Charleston to Des Moines

Discover the top 2 airlines that operate flights from Charleston to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$233Average$366FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$418FlexibilityNo cancel feeOn-timeN/A

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