How long is the flight from Charleston to Des Moines?

For as low as $325, Delta can have you in Des Moines from Charleston in 7h 07m. The distance between Charleston and Des Moines is about 956 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines flying from Charleston to Des Moines round-trip?

Currently priced at $233, American Airlines will fly you from Charleston to Des Moines and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $316. American Airlines is 47% cheaper than the average price of flights available within the next 90 days to this destination.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

What is the cheapest time of day to fly from CHS to DSM?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Charleston to Des Moines as you normally would.

Most accurate provider : When it comes to deals on Charleston-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Des Moines flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Charleston-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Charleston to Des Moines that include hotel bookings?

Yes. In addition to deals on Charleston to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Charleston to Des Moines?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Des Moines.

Can I find deals for business class flights from Charleston to Des Moines?

Yes. Cheapflights offers flight deals from Charleston to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$163+ Cheap Flights from Charleston to Des Moines

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Cheap flight deals from Charleston to Des Moines

Cheapest

Best

Last-minute

One-way

Cheapest flights from Charleston to Des Moines
Explore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 8, 2026.

Mon 12/77:35 pm -

1 stop4h 55m

Thu 12/105:24 am -

1 stop6h 39m

Deal found 11/4

$325

Mon 12/75:00 pm -

1 stop5h 25m

Wed 12/91:15 pm -

2 stops9h 44m

Deal found 11/4

$330

Tue 12/812:18 pm -

1 stop7h 43m

Thu 12/102:05 pm -

1 stop7h 03m

Deal found 11/7

$362

Sat 12/126:00 am -

1 stop7h 39m

Mon 12/141:15 pm -

1 stop7h 06m

Deal found 11/3

$425

Mon 12/76:35 am -

2 stops8h 40m

Thu 12/107:00 am -

2 stops8h 30m

Deal found 11/4

$457

Best flights from Charleston to Des Moines
Discover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 8, 2026.

Tue 12/224:31 pm -

1 stop7h 07m

Wed 12/236:43 pm -

1 stop4h 11m

Deal found 11/3

$325

Tue 12/86:02 am -

2 stops8h 33m

Thu 12/102:05 pm -

1 stop7h 03m

Deal found 11/7

$402

Sat 12/126:45 am -

2 stops8h 41m

Mon 12/141:15 pm -

1 stop7h 06m

Deal found 11/5

$430

Wed 11/184:15 pm -

1 stop8h 27m

Sat 11/2111:23 am -

1 stop5h 43m

Deal found 11/4

$537

Thu 11/193:29 pm -

1 stop4h 47m

Mon 11/239:50 am -

1 stop7h 16m

Deal found 11/4

$537

Last-minute flights from Charleston to Des Moines
Discover last-minute flight deals from Charleston to Des Moines. Data last updated November 8, 2026 and is based on user searches.

Mon 12/77:35 pm -

1 stop4h 55m

Thu 12/105:24 am -

1 stop6h 39m

Deal found 11/4

$325

Mon 12/75:00 pm -

1 stop5h 25m

Wed 12/91:15 pm -

2 stops9h 44m

Deal found 11/4

$330

Mon 12/76:35 am -

2 stops8h 40m

Thu 12/107:00 am -

2 stops8h 30m

Deal found 11/4

$457

Tue 12/812:18 pm -

1 stop7h 43m

Thu 12/102:05 pm -

1 stop7h 03m

Deal found 11/7

$362

Sat 12/126:00 am -

1 stop7h 39m

Mon 12/141:15 pm -

1 stop7h 06m

Deal found 11/3

$425

One-way flights from Charleston to Des Moines
Search for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated November 8, 2026.

Tue 1/51:05 pm -

1 stop5h 14m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/3

$163

Tue 1/52:19 pm -

2 stops9h 17m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/6

$214

Tue 1/53:23 pm -

2 stops8h 51m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/3

$218

Thu 5/65:30 pm -

1 stop4h 54m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/6

$224

Thu 5/65:13 am -

2 stops8h 42m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/6

$229

Sat 11/213:42 pm -

2 stops28h 51m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/7

$236

Thu 11/122:13 pm -

1 stop19h 08m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/5

$240

Thu 11/1912:18 pm -

1 stop7h 58m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/4

$269

Thu 11/1910:13 pm -

3 stops36h 48m

Wed 12/3112:00 am -

Nonstop0h 00m

Deal found 11/4

$290

Find flight deals from Charleston to Des Moines

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$325 (American Airlines)
One-way from	$163 (Delta)
Popular in	January
Cheapest in	April
Average price	$541

Provider with most accurate pricing for Charleston-Des Moines flight deals.

Search Deals

Provider most trusted by Cheapflights users for Charleston-Des Moines flights.

Search Deals

From Charleston to Des Moines

Search Deals

One-way flight from Charleston to Des Moines

Search Deals

Highest demand for flights based on searches. 14% potential increase in price ($73 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 4% potential price decrease ($22 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in November 2026

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Tue 1/5

1:05 pm-5:19 pm

1 stop5h 14m

Des Moines

Wed 12/31

12:00 am-1:00 am

Nonstop0h 00m

$163

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Tue 1/5

7:00 am-2:56 pm

2 stops8h 56m

Des Moines

Wed 12/31

12:00 am-1:00 am

Nonstop0h 00m

$214

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Tue 1/5

3:23 pm-11:14 pm

2 stops8h 51m

Des Moines

Wed 12/31

12:00 am-1:00 am

Nonstop0h 00m

$218

Quickest round-trip

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Thu 5/6

5:30 pm-9:24 pm

1 stop4h 54m

Des Moines

Wed 12/31

12:00 am-1:00 am

Nonstop0h 00m

$224

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Thu 11/12

2:13 pm-8:21 am

1 stop19h 08m

Des Moines

Wed 12/31

12:00 am-1:00 am

Nonstop0h 00m

$240

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Thu 11/19

12:18 pm-7:16 pm

1 stop7h 58m

Des Moines

Wed 12/31

12:00 am-1:00 am

Nonstop0h 00m

$269

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Thu 11/19

10:13 pm-10:01 am

3 stops36h 48m

Des Moines

Wed 12/31

12:00 am-1:00 am

Nonstop0h 00m

$290

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Tue 12/22

4:31 pm-10:38 pm

1 stop7h 07m

Des Moines

Wed 12/23

6:43 pm-11:54 pm

1 stop4h 11m

$325

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Tue 12/8

6:02 am-1:35 pm

2 stops8h 33m

Des Moines

Thu 12/10

2:05 pm-10:08 pm

1 stop7h 03m

$402

CharlestonDes Moines

CHS Charleston - DSM Des Moines

CHSDSM

Charleston

Sat 12/12

6:45 am-2:26 pm

2 stops8h 41m

Des Moines

Mon 12/14

1:15 pm-9:21 pm

1 stop7h 06m

$430

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Showing 1-10 of 12 resultsSorted by cheapest first

Compare providers for flights from Charleston to Des Moines

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Des Moines in November.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
eDreams	Price Accuracy2 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Charleston-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Des Moines flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Charleston-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Charleston to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Charleston with our price prediction graph.

CHS-DSM

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to Des Moines

What is the cheapest month to book a flight from Charleston to Des Moines?

Currently, April is the cheapest month in which you can book a flight from Charleston to Des Moines (average of $316). Flying from Charleston to Des Moines in January is currently the most expensive (average of $677). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get a feel of what it's like to fly with Delta and American Airlines from Charleston to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.8

Good

8,698 reviews

Reviews

1 / 20

6.0

Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Delta

7.8

Good

8,698 reviews

Delta

7.8

Good

8,698 reviews

Reviews

1 / 20

6.0

Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

American Airlines

7.0

Good

12,228 reviews

Delta

7.8

Good

8,698 reviews

Reviews

1 / 20

6.0

Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Related info for your journey

How long is the flight from Charleston to Des Moines?
For as low as $325, Delta can have you in Des Moines from Charleston in 7h 07m. The distance between Charleston and Des Moines is about 956 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from Charleston to Des Moines round-trip?
Currently priced at $233, American Airlines will fly you from Charleston to Des Moines and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $316. American Airlines is 47% cheaper than the average price of flights available within the next 90 days to this destination.
Can I find deals for flights from Charleston to Des Moines that include hotel bookings?
Yes. In addition to deals on Charleston to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Charleston to Des Moines?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to Des Moines.
Can I find deals for business class flights from Charleston to Des Moines?
Yes. Cheapflights offers flight deals from Charleston to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Charleston to Des Moines?
Currently, April is the cheapest month in which you can book a flight from Charleston to Des Moines (average of $316). Flying from Charleston to Des Moines in January is currently the most expensive (average of $677). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Altoona

Clive

West Des Moines

Ames

Johnston

Boone

Norwalk

Ankeny

Browse thousands of different options on Cheapflights for your next trip

Alternative routes

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Other flights from Charleston

Popular flights

Alternative routes for Charleston to Des Moines

Top 2 airlines flying from Charleston to Des Moines

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$233	Average$370	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$316	Average$502	FlexibilityNo cancel fee	On-timeN/A

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$163+ Cheap flights from Charleston to Des Moines (CHS - DSM)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/5. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Charleston to Des Moines with Cheapflights

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2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Charleston to Des Moines

Cheapest flights from Charleston to Des MoinesExplore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 8, 2026.

Explore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 8, 2026.

Best flights from Charleston to Des MoinesDiscover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 8, 2026.

Discover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 8, 2026.

Last-minute flights from Charleston to Des MoinesDiscover last-minute flight deals from Charleston to Des Moines. Data last updated November 8, 2026 and is based on user searches.

Discover last-minute flight deals from Charleston to Des Moines. Data last updated November 8, 2026 and is based on user searches.

One-way flights from Charleston to Des MoinesSearch for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated November 8, 2026.

Search for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated November 8, 2026.

Find flight deals from Charleston to Des Moines

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.

Compare providers for flights from Charleston to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Des Moines in November.

Best time to book a flight from Charleston to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Charleston with our price prediction graph.

Cheapflights Insights

What is the cheapest month to book a flight from Charleston to Des Moines?

Reviews of airlines servicing Des Moines

Get a feel of what it's like to fly with Delta and American Airlines from Charleston to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

How long is the flight from Charleston to Des Moines?

What are the cheapest airlines flying from Charleston to Des Moines round-trip?

Can I find deals for flights from Charleston to Des Moines that include hotel bookings?

How can I find direct flights from Charleston to Des Moines?

Can I find deals for business class flights from Charleston to Des Moines?

What is the cheapest month to book a flight from Charleston to Des Moines?

Traveling to a place near Des Moines?

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Alternative routes for Charleston to Des Moines

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Complete your trip

Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.

Other flights to Des Moines

Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 8, 2026.

Search flights from Charleston to Des Moines by cabin class

Find flights from Charleston to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Charleston and Des Moines flights

Browse other Charleston and Des Moines flight options. Last updated on November 8, 2026.

Other flights from Charleston

Browse through other flights departing from Charleston. Flights are based on user searches made on Cheapflights and were last updated on November 8, 2026.

Popular flight searches

Check out other popular destinations found by fellow travelers in 2026

Top 2 airlines flying from Charleston to Des Moines

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Cheapest flights from Charleston to Des Moines
Explore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 8, 2026.

Best flights from Charleston to Des Moines
Discover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 8, 2026.

Last-minute flights from Charleston to Des Moines
Discover last-minute flight deals from Charleston to Des Moines. Data last updated November 8, 2026 and is based on user searches.

One-way flights from Charleston to Des Moines
Search for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated November 8, 2026.