$133+ Cheap flights from Charleston to Des Moines (CHS - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Nov 24 — Dec 11
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Charleston to Des Moines
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Best
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One-way
Cheapest flights from Charleston to Des MoinesExplore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/312:17 pm -
1 stop7h 44m
Mon 12/79:23 am -
1 stop5h 03m
Deal found 10/21![American Airlines logo]()
$281
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am -
2 stops8h 14m
Mon 12/73:20 pm -
1 stop5h 01m
Deal found 10/21![United Airlines logo]()
$286
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/228:02 pm -
1 stop4h 56m
Wed 12/303:26 pm -
1 stop7h 54m
Deal found 10/22![American Airlines logo]()
$350
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/224:31 pm -
1 stop7h 07m
Wed 12/236:43 pm -
1 stop4h 11m
Deal found 10/22![Delta logo]()
$359
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/228:02 pm -
1 stop4h 56m
Wed 12/236:16 pm -
1 stop4h 43m
Deal found 10/22![American Airlines logo]()
$378
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/104:17 pm -
1 stop7h 18m
Thu 11/126:52 pm -
1 stop4h 07m
Deal found 10/22![Delta logo]()
$379
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:35 am -
2 stops8h 40m
Mon 12/77:00 am -
2 stops8h 30m
Deal found 10/21![Southwest logo]()
$397
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/238:09 pm -
1 stop25h 33m
Tue 12/296:45 pm -
1 stop23h 44m
Deal found 10/22![Multiple Airlines logo]()
$400
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/58:32 pm -
1 stop4h 25m
Mon 11/97:23 am -
1 stop7h 01m
Deal found 10/21![American Airlines logo]()
$409
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/54:00 pm -
2 stops8h 05m
Mon 11/95:25 am -
1 stop9h 25m
Deal found 10/21![Southwest logo]()
$420
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:14 pm -
1 stop7h 54m
Fri 11/68:44 am -
1 stop27h 40m
Deal found 10/20![Multiple Airlines logo]()
$442
Best flights from Charleston to Des MoinesDiscover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am -
2 stops8h 14m
Mon 12/73:20 pm -
1 stop5h 01m
Deal found 10/21![United Airlines logo]()
$286
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/104:17 pm -
1 stop7h 18m
Thu 11/126:52 pm -
1 stop4h 07m
Deal found 10/22![Delta logo]()
$379
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/54:00 pm -
2 stops8h 05m
Mon 11/95:25 am -
1 stop9h 25m
Deal found 10/21![Southwest logo]()
$420
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:14 pm -
1 stop7h 54m
Fri 11/68:30 pm -
2 stops23h 08m
Deal found 10/20![Multiple Airlines logo]()
$461
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/216:40 am -
1 stop5h 35m
Tue 12/225:10 am -
2 stops9h 50m
Deal found 10/22![Southwest logo]()
$442
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/99:46 am -
2 stops13h 44m
Wed 1/136:15 am -
1 stop6h 31m
Deal found 10/24![United Airlines logo]()
$444
This Southwest deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/224:45 pm -
1 stop6h 50m
Wed 12/235:10 am -
2 stops9h 50m
Deal found 10/24![Southwest logo]()
$468
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:52 pm -
1 stop23h 55m
Sat 11/79:00 am -
2 stops27h 37m
Deal found 10/20![Multiple Airlines logo]()
$542
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/102:52 pm -
2 stops9h 50m
Thu 11/125:30 am -
2 stops11h 34m
Deal found 10/22![United Airlines logo]()
$583
Last-minute flights from Charleston to Des MoinesDiscover last-minute flight deals from Charleston to Des Moines. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from Charleston to Des Moines. Data last updated October 25, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:14 pm -
1 stop7h 54m
Fri 11/68:44 am -
1 stop27h 40m
Deal found 10/20![Multiple Airlines logo]()
$442
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:14 pm -
1 stop7h 54m
Thu 11/54:15 pm -
1 stop27h 46m
Deal found 10/20![Multiple Airlines logo]()
$445
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:14 pm -
1 stop7h 54m
Sat 11/79:00 am -
1 stop22h 38m
Deal found 10/20![Multiple Airlines logo]()
$458
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:52 pm -
1 stop23h 55m
Fri 11/68:44 am -
1 stop27h 40m
Deal found 10/20![Multiple Airlines logo]()
$477
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:52 pm -
1 stop23h 55m
Thu 11/54:15 pm -
1 stop27h 46m
Deal found 10/20![Multiple Airlines logo]()
$480
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:52 pm -
1 stop23h 55m
Sat 11/79:00 am -
1 stop22h 38m
Deal found 10/20![Multiple Airlines logo]()
$493
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/58:32 pm -
1 stop4h 25m
Mon 11/97:23 am -
1 stop7h 01m
Deal found 10/21![American Airlines logo]()
$409
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/54:00 pm -
2 stops8h 05m
Mon 11/95:25 am -
1 stop9h 25m
Deal found 10/21![Southwest logo]()
$420
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/510:23 am -
2 stops8h 05m
Mon 11/96:05 am -
2 stops7h 23m
Deal found 10/21![United Airlines logo]()
$466
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/104:17 pm -
1 stop7h 18m
Thu 11/126:52 pm -
1 stop4h 07m
Deal found 10/22![Delta logo]()
$379
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/102:40 pm -
2 stops8h 14m
Thu 11/129:25 am -
1 stop13h 52m
Deal found 10/22![American Airlines logo]()
$462
One-way flights from Charleston to Des MoinesSearch for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:14 pm -
1 stop8h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Multiple Airlines logo]()
$133
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:00 pm -
1 stop4h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![United Airlines logo]()
$141
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/184:55 pm -
1 stop7h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![United Airlines logo]()
$180
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1310:23 am -
2 stops9h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![United Airlines logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/173:00 pm -
3 stops50h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/182:49 pm -
1 stop8h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:45 am -
2 stops40h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$219
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/185:55 am -
2 stops10h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Southwest logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/122:13 pm -
3 stops30h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/194:10 pm -
3 stops53h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$268
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:27 am -
1 stop5h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![American Airlines logo]()
$269
Find flight deals from Charleston to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $281 (American Airlines) |
One-way from | $133 (Kiwi.com) |
Popular in | June |
Cheapest in | April |
Average price | $396 |
Cheapflights Fare Finder
Customize your flight search to find flights from Charleston to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Thu 11/12
7:00 pm-10:59 pm
1 stop4h 59m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$141
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Tue 11/17
6:10 am-10:10 am
1 stop5h 00m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$141
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Tue 11/17
1:30 pm-10:05 pm
2 stops9h 35m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$146
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Thu 12/17
6:00 am-4:16 pm
2 stops11h 16m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$146
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Fri 12/18
4:55 pm-11:17 pm
1 stop7h 22m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$180
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Fri 11/13
10:23 am-7:16 pm
2 stops9h 53m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$185
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Tue 11/17
3:00 pm-4:11 pm
3 stops50h 11m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$207
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Fri 12/18
2:49 pm-10:04 pm
1 stop8h 15m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$209
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Thu 11/5
6:45 am-10:15 pm
2 stops40h 30m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$219
CharlestonDes Moines
CHS Charleston - DSM Des Moines
CHSDSM
Charleston
Fri 12/18
5:55 am-3:05 pm
2 stops10h 10m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$224
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Charleston to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Des Moines in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Charleston-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Charleston-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Charleston to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Charleston with our price prediction graph.
CHS-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Charleston to Des Moines
What is the cheapest month to book a flight from Charleston to Des Moines?
Currently, April is the cheapest month in which you can book a flight from Charleston to Des Moines (average of $316). Flying from Charleston to Des Moines in June is currently the most expensive (average of $618). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Charleston to Des Moines?
Airfare is below average for this route at the moment.
Charleston to Des Moines flights typically cost between $392 and $468 in December.The cheapest round-trip price found within the last 5 days was $281 on American Airlines (Dec 3-Dec 7).
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 25, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Charleston to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Overall
7.8
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Food
7.2
Overall
7.8
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Food
7.2
Overall
7.8
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Charleston to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
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Top 2 airlines flying from Charleston to Des Moines
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$233 | Average$354 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$316 | Average$502 | FlexibilityNo cancel fee | On-timeN/A |