$133+ Cheap flights from Charleston to Des Moines (CHS - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
May 9 — May 161
Round-trip
1 adult, Economy
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Find cheap flights from Charleston to Des Moines with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Charleston to Des Moines
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Best
Last-minute
One-way
Cheapest flights from Charleston to Des MoinesExplore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.
Explore the most affordable flight options available from Charleston to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:15 am
CHS
- DSM
1 stop5h 10m
Southwest
Tue 5/193:15 pm
DSM
- CHS
1 stop4h 50m
Southwest
Deal found 4/6![Southwest logo]()
$335
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:08 pm
CHS
- DSM
1 stop7h 16m
United Airlines
Sat 5/96:15 am
DSM
- CHS
1 stop6h 36m
United Airlines
Deal found 4/6![United Airlines logo]()
$346
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:15 am
CHS
- DSM
1 stop5h 10m
Southwest
Sat 5/96:40 am
DSM
- CHS
2 stops10h 25m
Southwest
Deal found 4/6![Southwest logo]()
$351
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:20 am
CHS
- DSM
1 stop4h 48m
Delta
Tue 5/196:41 pm
DSM
- CHS
1 stop4h 18m
Delta
Deal found 4/6![Delta logo]()
$353
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:15 am
CHS
- DSM
1 stop5h 53m
Delta
Mon 5/186:41 pm
DSM
- CHS
1 stop4h 18m
Delta
Deal found 4/8![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:15 am
CHS
- DSM
1 stop5h 10m
Southwest
Mon 5/185:25 am
DSM
- CHS
2 stops6h 10m
Southwest
Deal found 4/6![Southwest logo]()
$360
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2712:58 pm
CHS
- DSM
2 stops7h 34m
American Airlines
Sat 5/301:48 pm
DSM
- CHS
2 stops7h 24m
American Airlines
Deal found 4/6![American Airlines logo]()
$365
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/28:00 am
CHS
- DSM
1 stop4h 30m
Southwest
Mon 5/44:20 pm
DSM
- CHS
1 stop4h 35m
Southwest
Deal found 4/8![Southwest logo]()
$366
Best flights from Charleston to Des MoinesDiscover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 9, 2026.
Discover carefully curated flight deals from Charleston to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 9, 2026.
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1312:00 pm
CHS
- DSM
2 stops11h 10m
Southwest
Tue 5/195:30 am
DSM
- CHS
2 stops8h 30m
Southwest
Deal found 4/8![Southwest logo]()
$351
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:35 am
CHS
- DSM
2 stops8h 19m
American Airlines
Mon 5/183:00 pm
DSM
- CHS
1 stop6h 16m
American Airlines
Deal found 4/5![American Airlines logo]()
$360
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/207:05 am
CHS
- DSM
1 stop4h 50m
Delta
Wed 6/2410:23 am
DSM
- CHS
1 stop6h 31m
Delta
Deal found 4/4![Delta logo]()
$371
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:15 am
CHS
- DSM
1 stop5h 10m
Southwest
Mon 5/185:25 am
DSM
- CHS
2 stops6h 10m
Southwest
Deal found 4/8![Southwest logo]()
$360
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:15 am
CHS
- DSM
1 stop5h 53m
Delta
Mon 5/186:41 pm
DSM
- CHS
1 stop4h 18m
Delta
Deal found 4/6![Delta logo]()
$373
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:15 am
CHS
- DSM
1 stop6h 53m
Delta
Tue 5/196:41 pm
DSM
- CHS
1 stop4h 18m
Delta
Deal found 4/6![Delta logo]()
$373
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:35 am
CHS
- DSM
2 stops14h 20m
Southwest
Mon 5/45:25 am
DSM
- CHS
2 stops7h 10m
Southwest
Deal found 4/8![Southwest logo]()
$376
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:03 pm
CHS
- DSM
1 stop5h 29m
Delta
Mon 5/186:41 pm
DSM
- CHS
1 stop4h 18m
Delta
Deal found 4/5![Delta logo]()
$391
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/72:15 pm
CHS
- DSM
2 stops9h 50m
Southwest
Sun 5/105:20 am
DSM
- CHS
2 stops9h 30m
Southwest
Deal found 4/6![Southwest logo]()
$401
Last-minute flights from Charleston to Des MoinesDiscover last-minute flight deals from Charleston to Des Moines. Data last updated April 9, 2026 and is based on user searches.
Discover last-minute flight deals from Charleston to Des Moines. Data last updated April 9, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/28:00 am
CHS
- DSM
1 stop4h 30m
Southwest
Mon 5/44:20 pm
DSM
- CHS
1 stop4h 35m
Southwest
Deal found 4/8![Southwest logo]()
$366
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:08 pm
CHS
- DSM
1 stop7h 16m
United Airlines
Sat 5/96:15 am
DSM
- CHS
1 stop6h 36m
United Airlines
Deal found 4/6![United Airlines logo]()
$346
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:15 am
CHS
- DSM
1 stop5h 10m
Southwest
Sat 5/96:40 am
DSM
- CHS
2 stops10h 25m
Southwest
Deal found 4/6![Southwest logo]()
$351
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:15 am
CHS
- DSM
1 stop5h 10m
Southwest
Tue 5/193:15 pm
DSM
- CHS
1 stop4h 50m
Southwest
Deal found 4/6![Southwest logo]()
$335
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:20 am
CHS
- DSM
1 stop4h 48m
Delta
Tue 5/196:41 pm
DSM
- CHS
1 stop4h 18m
Delta
Deal found 4/6![Delta logo]()
$353
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:15 am
CHS
- DSM
1 stop5h 53m
Delta
Mon 5/186:41 pm
DSM
- CHS
1 stop4h 18m
Delta
Deal found 4/8![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:15 am
CHS
- DSM
1 stop5h 10m
Southwest
Mon 5/185:25 am
DSM
- CHS
2 stops6h 10m
Southwest
Deal found 4/6![Southwest logo]()
$360
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2712:58 pm
CHS
- DSM
2 stops7h 34m
American Airlines
Sat 5/301:48 pm
DSM
- CHS
2 stops7h 24m
American Airlines
Deal found 4/6![American Airlines logo]()
$365
One-way flights from Charleston to Des MoinesSearch for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 9, 2026.
Search for one-way flight options from Charleston to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/274:34 pm
CHS
- DSM
1 stop17h 19m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$133
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2712:58 pm
CHS
- DSM
2 stops7h 34m
American Airlines
Deal found 4/6![American Airlines logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:00 am
CHS
- DSM
2 stops16h 06m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$185
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:00 am
CHS
- DSM
1 stop5h 37m
United Airlines
Deal found 4/6![United Airlines logo]()
$188
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/305:00 am
CHS
- DSM
2 stops8h 55m
American Airlines
Deal found 4/6![American Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/252:53 pm
CHS
- DSM
2 stops27h 02m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$195
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/277:05 am
CHS
- DSM
1 stop4h 50m
Delta
Deal found 4/9![Delta logo]()
$204
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:45 am
CHS
- DSM
2 stops7h 33m
American Airlines
Deal found 4/5![American Airlines logo]()
$209
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:51 pm
CHS
- DSM
1 stop8h 08m
American Airlines
Deal found 4/6![American Airlines logo]()
$214
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/31:00 pm
CHS
- DSM
2 stops7h 36m
American Airlines
Deal found 4/6![American Airlines logo]()
$217
Find flight deals from Charleston to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $335 (Southwest) |
One-way from | $133 (Kiwi.com) |
Popular in | November |
Cheapest in | May |
Average price | $316 |
Cheapflights Fare Finder
Customize your flight search to find flights from Charleston to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
Use the filters below to find and compare flights from Charleston to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Wed 5/13
12:00 pm-10:10 pm
2 stops11h 10m
Des Moines
Tue 5/19
5:30 am-3:00 pm
2 stops8h 30m
$351
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Wed 5/13
6:35 am-1:54 pm
2 stops8h 19m
Des Moines
Mon 5/18
3:00 pm-10:16 pm
1 stop6h 16m
$360
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Wed 5/13
7:15 am-11:25 am
1 stop5h 10m
Des Moines
Mon 5/18
5:25 am-12:35 pm
2 stops6h 10m
$360
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Sat 6/20
7:05 am-10:55 am
1 stop4h 50m
Des Moines
Wed 6/24
10:23 am-5:54 pm
1 stop6h 31m
$371
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Tue 5/12
6:15 am-11:08 am
1 stop5h 53m
Des Moines
Mon 5/18
6:41 pm-11:59 pm
1 stop4h 18m
$373
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Mon 5/11
5:15 am-11:08 am
1 stop6h 53m
Des Moines
Tue 5/19
6:41 pm-11:59 pm
1 stop4h 18m
$373
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Sat 5/2
7:35 am-8:55 pm
2 stops14h 20m
Des Moines
Mon 5/4
5:25 am-1:35 pm
2 stops7h 10m
$376
Quickest round-trip
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Fri 5/15
6:03 pm-10:32 pm
1 stop5h 29m
Des Moines
Mon 5/18
6:41 pm-11:59 pm
1 stop4h 18m
$391
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Thu 5/7
2:15 pm-11:05 pm
2 stops9h 50m
Des Moines
Sun 5/10
5:20 am-3:50 pm
2 stops9h 30m
$401
Cheapest one-way
Quickest one-way
CharlestonDes Moines
CHS - DSM
CHSDSM
Charleston
Thu 4/30
7:25 am-11:05 am
1 stop4h 40m
$188
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Charleston to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to Des Moines in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Charleston-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Charleston-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Charleston to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Charleston with our price prediction graph.
CHS-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Charleston to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 9, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Charleston to Des Moines by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Comfort
7.9
Food
7.2
Crew
8.5
Overall
7.9
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Comfort
7.9
Food
7.2
Crew
8.5
Overall
7.9
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Comfort
7.9
Food
7.2
Crew
8.5
Overall
7.9
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Charleston to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ames
Clive
Ankeny
Boone
West Des Moines
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 9, 2026.
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Charleston and Des Moines flights
Browse other Charleston and Des Moines flight options. Last updated on April 9, 2026.
Other flights from Charleston
Browse through other flights departing from Charleston. Flights are based on user searches made on Cheapflights and were last updated on April 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Charleston to Des Moines
Discover the top 2 airlines that operate flights from Charleston to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$233 | Average$366 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$418 | FlexibilityNo cancel fee | On-timeN/A |