$70+ Cheap flights from South Carolina to St. Louis (STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/28. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
May 5 — May 121
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to St. Louis
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Cheapest flights from South Carolina to St. LouisExplore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 5, 2026.
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 5, 2026.
This Trip.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Fri 4/248:39 am
STL
- CLT
1 stop6h 34m
Frontier
Deal found 4/3![Frontier logo]()
$170
This CheapOair deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Mon 4/274:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Deal found 3/31![Frontier logo]()
$171
This Priceline deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:55 am
CLT
- STL
1 stop10h 11m
Frontier
Sat 6/66:30 pm
STL
- CLT
1 stop11h 29m
Frontier
Deal found 4/3![Frontier logo]()
$180
This Frontier deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:00 pm
CLT
- STL
1 stop11h 57m
Frontier
Wed 6/36:51 pm
STL
- CLT
1 stop11h 08m
Frontier
Deal found 4/3![Frontier logo]()
$181
This Frontier deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:58 pm
CLT
- STL
1 stop5h 23m
Frontier
Wed 6/106:58 pm
STL
- CLT
1 stop11h 17m
Frontier
Deal found 3/31![Frontier logo]()
$185
This CheapOair deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:14 pm
CLT
- STL
1 stop25h 09m
Frontier
Thu 6/49:06 pm
STL
- CLT
1 stop8h 53m
Frontier
Deal found 4/3![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Sun 4/264:59 pm
STL
- CLT
1 stop15h 28m
Frontier
Deal found 4/1![Frontier logo]()
$192
This CheapOair deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:30 pm
CLT
- STL
1 stop5h 49m
Frontier
Tue 4/284:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Deal found 4/1![Frontier logo]()
$196
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/297:26 am
CLT
- STL
Nonstop2h 04m
American Airlines
Wed 5/137:00 am
STL
- CLT
Nonstop2h 02m
American Airlines
Deal found 4/3![American Airlines logo]()
$197
This Expedia deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Thu 4/168:06 pm
STL
- CLT
1 stop20h 29m
Frontier
Deal found 4/1![Frontier logo]()
$201
This Expedia deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/221:00 pm
CLT
- STL
1 stop12h 21m
Frontier
Tue 5/264:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Deal found 3/31![Frontier logo]()
$205
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:20 pm
CLT
- STL
1 stop3h 40m
Southwest
Wed 6/104:50 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 3/31![Southwest logo]()
$207
Best flights from South Carolina to St. LouisDiscover carefully curated flight deals from South Carolina to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 5, 2026.
Discover carefully curated flight deals from South Carolina to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 5, 2026.
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:30 am
CLT
- STL
1 stop4h 00m
Delta
Thu 4/306:00 am
STL
- CLT
1 stop4h 11m
Delta
Deal found 3/31![Delta logo]()
$238
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/164:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Tue 5/193:45 pm
STL
- CHS
1 stop4h 20m
Southwest
Deal found 3/31![Southwest logo]()
$238
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:06 am
CHS
- STL
1 stop5h 31m
American Airlines
Tue 6/235:08 am
STL
- CHS
1 stop7h 21m
American Airlines
Deal found 3/31![American Airlines logo]()
$287
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/288:05 am
CLT
- STL
1 stop5h 06m
United Airlines
Sat 7/41:13 pm
STL
- CLT
1 stop7h 16m
United Airlines
Deal found 4/2![United Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/164:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Mon 5/182:10 pm
STL
- CHS
Nonstop1h 55m
Southwest
Deal found 4/4![Southwest logo]()
$239
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:20 pm
CLT
- STL
1 stop4h 50m
Southwest
Thu 4/3010:15 am
STL
- CLT
2 stops7h 30m
Southwest
Deal found 4/1![Southwest logo]()
$243
This Delta deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:59 pm
CHS
- STL
1 stop4h 57m
Delta
Tue 6/2310:20 am
STL
- CHS
1 stop6h 34m
Delta
Deal found 4/3![Delta logo]()
$287
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:15 am
CLT
- STL
2 stops7h 35m
Southwest
Tue 4/2811:35 am
STL
- CLT
2 stops8h 20m
Southwest
Deal found 4/1![Southwest logo]()
$248
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/243:05 pm
HHH
- STL
1 stop7h 08m
United Airlines
Sat 5/26:30 am
STL
- HHH
2 stops8h 11m
United Airlines
Deal found 4/2![United Airlines logo]()
$330
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:40 am
CAE
- STL
1 stop3h 38m
Delta
Wed 6/106:05 am
STL
- CAE
1 stop8h 20m
Delta
Deal found 3/31![Delta logo]()
$305
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/48:00 am
CHS
- STL
1 stop5h 10m
Southwest
Tue 6/910:15 am
STL
- CHS
2 stops9h 10m
Southwest
Deal found 4/1![Southwest logo]()
$253
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:00 am
SAV
- STL
1 stop5h 16m
American Airlines
Mon 5/45:20 am
STL
- SAV
1 stop5h 25m
American Airlines
Deal found 3/31![American Airlines logo]()
$341
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:04 pm
SAV
- STL
1 stop5h 09m
United Airlines
Mon 4/206:30 am
STL
- SAV
1 stop7h 10m
United Airlines
Deal found 3/31![United Airlines logo]()
$341
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:35 am
CLT
- STL
1 stop5h 09m
Delta
Sun 5/106:00 am
STL
- CLT
1 stop4h 05m
Delta
Deal found 4/4![Delta logo]()
$313
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:10 am
CLT
- STL
1 stop6h 35m
Southwest
Sun 5/1011:40 am
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 4/5![Southwest logo]()
$260
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/174:52 pm
MYR
- STL
1 stop7h 07m
American Airlines
Mon 4/205:51 am
STL
- MYR
1 stop5h 13m
American Airlines
Deal found 3/31![American Airlines logo]()
$351
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1711:31 am
SAV
- STL
1 stop5h 17m
United Airlines
Mon 4/207:45 am
STL
- SAV
1 stop5h 55m
United Airlines
Deal found 3/31![United Airlines logo]()
$341
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/276:01 pm
CAE
- STL
1 stop6h 52m
Delta
Sat 8/15:36 pm
STL
- CAE
1 stop5h 13m
Delta
Deal found 4/1![Delta logo]()
$314
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:06 pm
MYR
- STL
2 stops6h 48m
American Airlines
Tue 5/265:08 am
STL
- MYR
1 stop5h 29m
American Airlines
Deal found 3/31![American Airlines logo]()
$356
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:15 am
CLT
- STL
2 stops7h 35m
Southwest
Thu 4/3010:15 am
STL
- CLT
2 stops7h 30m
Southwest
Deal found 4/1![Southwest logo]()
$269
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/173:15 pm
MYR
- STL
1 stop6h 58m
United Airlines
Tue 4/216:30 am
STL
- MYR
1 stop6h 47m
United Airlines
Deal found 4/1![United Airlines logo]()
$346
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:35 am
CAE
- STL
1 stop5h 11m
Delta
Sat 7/48:00 am
STL
- CAE
1 stop6h 09m
Delta
Deal found 4/2![Delta logo]()
$315
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:05 am
FLO
- STL
1 stop4h 28m
American Airlines
Mon 5/257:30 am
STL
- FLO
1 stop5h 40m
American Airlines
Deal found 4/1![American Airlines logo]()
$361
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/59:15 pm
CLT
- STL
1 stop3h 50m
Southwest
Mon 6/83:35 pm
STL
- CLT
2 stops6h 40m
Southwest
Deal found 4/2![Southwest logo]()
$280
This Southwest deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:30 pm
CLT
- STL
1 stop3h 45m
Southwest
Sat 4/256:10 am
STL
- CLT
2 stops8h 00m
Southwest
Deal found 4/4![Southwest logo]()
$280
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:35 am
CLT
- STL
1 stop3h 35m
Delta
Sun 5/177:01 pm
STL
- CLT
1 stop3h 52m
Delta
Deal found 3/31![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:27 pm
AGS
- STL
1 stop6h 17m
American Airlines
Mon 6/16:12 pm
STL
- AGS
1 stop4h 47m
American Airlines
Deal found 4/1![American Airlines logo]()
$382
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/243:05 pm
HHH
- STL
1 stop7h 47m
United Airlines
Mon 5/46:30 am
STL
- HHH
1 stop6h 41m
United Airlines
Deal found 4/2![United Airlines logo]()
$405
This Delta deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/305:35 am
SAV
- STL
1 stop3h 55m
Delta
Mon 5/44:41 pm
STL
- SAV
1 stop6h 18m
Delta
Deal found 4/3![Delta logo]()
$341
This Southwest deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:45 pm
CHS
- STL
1 stop7h 40m
Southwest
Tue 4/2812:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Deal found 4/3![Southwest logo]()
$288
Last-minute flights from South Carolina to St. LouisDiscover last-minute flight deals from South Carolina to St. Louis. Data last updated April 5, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to St. Louis. Data last updated April 5, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/121:46 pm
CLT
- STL
1 stop19h 05m
Frontier
Wed 4/154:59 pm
STL
- CLT
1 stop14h 34m
Frontier
Deal found 3/31![Frontier logo]()
$212
This Expedia deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Thu 4/168:06 pm
STL
- CLT
1 stop20h 29m
Frontier
Deal found 4/1![Frontier logo]()
$201
This Trip.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Fri 4/248:39 am
STL
- CLT
1 stop6h 34m
Frontier
Deal found 4/3![Frontier logo]()
$170
This CheapOair deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Mon 4/274:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Deal found 3/31![Frontier logo]()
$171
This CheapOair deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Sun 4/264:59 pm
STL
- CLT
1 stop15h 28m
Frontier
Deal found 4/1![Frontier logo]()
$192
This CheapOair deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:30 pm
CLT
- STL
1 stop5h 49m
Frontier
Tue 4/284:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Deal found 4/1![Frontier logo]()
$196
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/297:26 am
CLT
- STL
Nonstop2h 04m
American Airlines
Wed 5/137:00 am
STL
- CLT
Nonstop2h 02m
American Airlines
Deal found 4/3![American Airlines logo]()
$197
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/299:36 am
CLT
- STL
1 stop4h 29m
Delta
Wed 5/1310:19 am
STL
- CLT
1 stop4h 31m
Delta
Deal found 4/1![Delta logo]()
$217
This CheapOair deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:17 am
CLT
- STL
1 stop7h 59m
Frontier
Sat 5/24:59 pm
STL
- CLT
1 stop13h 11m
Frontier
Deal found 4/3![Frontier logo]()
$216
This Southwest deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/133:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Tue 5/1912:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Deal found 4/3![Southwest logo]()
$217
This Expedia deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/221:00 pm
CLT
- STL
1 stop12h 21m
Frontier
Tue 5/264:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Deal found 3/31![Frontier logo]()
$205
This Priceline deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:55 am
CLT
- STL
1 stop10h 11m
Frontier
Sat 6/66:30 pm
STL
- CLT
1 stop11h 29m
Frontier
Deal found 4/3![Frontier logo]()
$180
One-way flights from South Carolina to St. LouisSearch for one-way flight options from South Carolina to St. Louis. Find affordable one-way fares based on user searches. Data last updated April 5, 2026.
Search for one-way flight options from South Carolina to St. Louis. Find affordable one-way fares based on user searches. Data last updated April 5, 2026.
This Frontier deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Deal found 4/2![Frontier logo]()
$70
This Frontier deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:58 pm
CLT
- STL
1 stop5h 23m
Frontier
Deal found 4/1![Frontier logo]()
$90
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:00 pm
CLT
- STL
1 stop6h 19m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$95
This Frontier deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:00 pm
CLT
- STL
1 stop11h 57m
Frontier
Deal found 4/4![Frontier logo]()
$96
This Trip.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Deal found 4/3![Frontier logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/28:09 pm
CLT
- STL
2 stops35h 41m
Frontier
Deal found 4/3![Frontier logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:54 pm
CLT
- STL
2 stops33h 56m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/241:45 pm
SAV
- STL
2 stops18h 05m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$108
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:59 am
CLT
- STL
1 stop6h 35m
Delta
Deal found 4/1![Delta logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/271:45 pm
SAV
- STL
2 stops42h 05m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$109
This Southwest deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/33:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 4/4![Southwest logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:30 am
CLT
- STL
2 stops26h 25m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$110
Find flight deals from South Carolina to St. Louis
Keep the following information in mind while searching for South Carolina to St. Louis flight deals. Data was last updated April 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $170 (Trip.com) |
One-way from | $70 (Frontier) |
Popular in | December |
Cheapest in | August |
Average price | $418 |
Good round-trip deal | $366 or less |
Good one-way deal | $179 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 5, 2026.
Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 4/29
5:30 am-8:30 am
1 stop4h 00m
Lambert-St Louis
Thu 4/30
6:00 am-11:11 am
1 stop4h 11m
$238
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Sat 5/16
4:40 pm-6:00 pm
Nonstop2h 20m
Lambert-St Louis
Tue 5/19
3:45 pm-9:05 pm
1 stop4h 20m
$238
Quickest round-trip
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Sat 5/16
4:40 pm-6:00 pm
Nonstop2h 20m
Lambert-St Louis
Mon 5/18
2:10 pm-5:05 pm
Nonstop1h 55m
$239
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 4/22
6:20 pm-10:10 pm
1 stop4h 50m
Lambert-St Louis
Thu 4/30
10:15 am-6:45 pm
2 stops7h 30m
$243
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Thu 4/23
6:15 am-12:50 pm
2 stops7h 35m
Lambert-St Louis
Tue 4/28
11:35 am-8:55 pm
2 stops8h 20m
$248
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Thu 6/4
8:00 am-12:10 pm
1 stop5h 10m
Lambert-St Louis
Tue 6/9
10:15 am-8:25 pm
2 stops9h 10m
$253
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Sat 5/9
6:10 am-11:45 am
1 stop6h 35m
Lambert-St Louis
Sun 5/10
11:40 am-2:30 pm
Nonstop1h 50m
$260
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Thu 4/23
6:15 am-12:50 pm
2 stops7h 35m
Lambert-St Louis
Thu 4/30
10:15 am-6:45 pm
2 stops7h 30m
$269
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Fri 6/5
9:15 pm-12:05 am
1 stop3h 50m
Lambert-St Louis
Mon 6/8
3:35 pm-11:15 pm
2 stops6h 40m
$280
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Fri 4/24
8:30 pm-11:15 pm
1 stop3h 45m
Lambert-St Louis
Sat 4/25
6:10 am-3:10 pm
2 stops8h 00m
$280
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.
CLT-STL
CHS-STL
CAE-STL
AGS-STL
SAV-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to St. Louis
USSC-STL
CLT-STL
CHS-STL
CAE-STL
AGS-STL
What is the cheapest month to book a flight from South Carolina to St. Louis?
Currently, June is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $108). Flying from South Carolina to St. Louis in January is currently the most expensive (average of $300). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to STL?
Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 5, 2026.
One of the essential ways to save on airfare from South Carolina to St. Louis is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 14% on airfare.
What is the cheapest day to fly from South Carolina to St. Louis?
Use this chart to determine the cheapest time to fly round-trip from South Carolina to St. Louis. Price data was last updated on March 28, 2026.
Travelers seeking maximum savings on their South Carolina to St. Louis flight should consider departing on Saturday mornings when fares are most often at their lowest. Friday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
How much does it cost to fly round-trip from South Carolina to St. Louis?
Related info for your journey
Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for South Carolina to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to St. Louis by cabin class
Find flights from South Carolina to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and St. Louis flights
Browse other South Carolina and St. Louis flight options. Last updated on April 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 5, 2026.
South Carolina to St. Louis flights
Consider these flights traveling from South Carolina to St. Louis.
Top 3 airlines flying from South Carolina to St. Louis
Discover the top 3 airlines that operate flights from South Carolina to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$128 | Average$342 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$229 | Average$382 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$287 | Average$383 | FlexibilityNo cancel fee | On-time63% |