$72+ Cheap flights from South Carolina to St. Louis (STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/13. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from South Carolina to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to St. Louis
Keep the following information in mind while searching for South Carolina to St. Louis flight deals. Data was last updated June 15, 2025.
Round-trip from | $166 (Mytrip) |
|---|---|
One-way from | $72 (American Airlines) |
Popular in | February |
Cheapest in | August |
Average price | $323 |
Good round-trip deal | $314 or less |
Good one-way deal | $271 or less |
Find flight deals from South Carolina to St. Louis
Cheapest flights from South Carolina to St. LouisExplore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2025.
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2025.
This Mytrip deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Booking.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Booking.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Booking.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2025.
Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Thu 7/17
6:29 pm-9:52 am
1 stop16h 23m
Lambert-St Louis
Mon 7/21
10:47 am-5:24 pm
1 stop5h 37m
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Mon 7/7
9:17 pm-11:47 pm
1 stop27h 30m
Lambert-St Louis
Mon 7/14
10:47 am-5:24 pm
1 stop5h 37m
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Mon 7/7
9:17 pm-11:47 pm
1 stop27h 30m
Lambert-St Louis
Wed 7/9
5:40 pm-11:42 am
1 stop17h 02m
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Thu 7/24
10:53 am-9:52 am
1 stop23h 59m
Lambert-St Louis
Sun 7/27
10:47 am-9:53 am
1 stop22h 06m
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Tue 7/22
7:21 am-8:14 am
Nonstop1h 53m
Lambert-St Louis
Tue 7/29
12:41 pm-3:39 pm
Nonstop1h 58m
ColumbiaSt. Louis
CAE - STL
CAESTL
Columbia Metropolitan
Mon 6/30
5:40 am-9:15 am
1 stop4h 35m
Lambert-St Louis
Fri 7/4
1:30 pm-7:09 pm
1 stop4h 39m
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Tue 9/9
6:34 pm-10:50 pm
1 stop5h 16m
Lambert-St Louis
Thu 9/11
3:34 pm-10:45 pm
1 stop6h 11m
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Tue 9/9
3:25 pm-9:55 pm
1 stop7h 30m
Lambert-St Louis
Thu 9/11
11:50 am-9:00 pm
2 stops8h 10m
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Thu 8/7
7:50 pm-8:50 pm
Nonstop2h 00m
Lambert-St Louis
Thu 8/14
2:45 pm-5:35 pm
Nonstop1h 50m
ColumbiaSt. Louis
CAE - STL
CAESTL
Columbia Metropolitan
Mon 7/14
4:37 pm-4:31 pm
1 stop24h 54m
Lambert-St Louis
Mon 7/21
10:47 am-2:04 pm
2 stops26h 17m
Best time to book a flight from South Carolina to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to St. Louis
What is the cheapest month to book a flight from South Carolina to St. Louis?
Currently, August is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $311). Flying from South Carolina to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to STL?
Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 15, 2025.
When flying from South Carolina to St. Louis, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
Weekly flight availability from South Carolina to St. Louis
Explore weekly flight availability from South Carolina to St. Louis. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 15, 2025.
The most flights from USSC to STL are scheduled on a Monday (1 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (1 on average).
Rainfall in St. Louis by month
Plan your trip to St. Louis by taking into account the average rainfall totals by month.
In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.
Temperature in St. Louis by month
Plan your trip to St. Louis by taking into account the average temperature totals by month.
If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated June 15, 2025.
Read through reviews of airlines operating flights from South Carolina to St. Louis, such as Southwest, Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
Entertainment
Comfort
Food
Boarding
Crew
Reviews
John,May 2025
PVD - BNA
Overall
Entertainment
Comfort
Food
Boarding
Crew
Reviews
John,May 2025
PVD - BNA
Overall
Entertainment
Comfort
Food
Boarding
Crew
Reviews
John,May 2025
PVD - BNA
Overall
Entertainment
Comfort
Food
Boarding
Crew
Reviews
John,May 2025
PVD - BNA
Overall
Entertainment
Comfort
Food
Boarding
Crew
Reviews
John,May 2025
PVD - BNA
Overall
Entertainment
Comfort
Food
Boarding
Crew
Reviews
John,May 2025
PVD - BNA
Related info for your journey
Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near South Carolina?
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Alternative routes for South Carolina to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Top 3 airlines flying from South Carolina to St. Louis
Discover the top 3 airlines that operate flights from South Carolina to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$172 | Average$359 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$360 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$286 | Average$367 | FlexibilityNo cancel fee | On-time63% |