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St. Louis

$73+ Cheap flights from South Carolina to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/30. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Aug 21 — Aug 281
Thu 8/21
Thu 8/28
1 adult, Economy
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Cheap flight deals from South Carolina to St. Louis

Keep the following information in mind while searching for South Carolina to St. Louis flight deals. Data was last updated August 16, 2025.

Round-trip from

$187
(American Airlines)

One-way from

$73
(Priceline)

Popular in

December

Cheapest in

August

Average price

$271

Good round-trip deal

$394 or less

Good one-way deal

$289 or less
From South Carolina to Lambert-St Louis
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One-way flight from South Carolina to Lambert-St Louis
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Highest demand for flights based on searches. 4% potential increase in price ($18 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($4 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Price to beat on a round-trip flight from South Carolina to Lambert-St Louis.
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Price to beat on a one-way flight from South Carolina to Lambert-St Louis.
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Find flight deals from South Carolina to St. Louis

Cheapest flights from South Carolina to St. Louis
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 16, 2025.

This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/194:22 pmCHS - STL
1 stop5h 48mAmerican Airlines
Sun 9/216:00 amSTL - CHS
1 stop7h 28mAmerican Airlines
Deal found 8/14$187
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/272:59 pmCHS - STL
2 stops7h 54mAmerican Airlines
Mon 9/296:00 amSTL - CHS
1 stop7h 28mAmerican Airlines
Deal found 8/14$192
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/53:59 pmMYR - STL
1 stop6h 07mAmerican Airlines
Mon 9/86:00 amSTL - MYR
1 stop7h 29mAmerican Airlines
Deal found 8/14$193
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/252:14 pmCHS - STL
1 stop7h 56mAmerican Airlines
Mon 9/296:00 amSTL - CHS
1 stop7h 28mAmerican Airlines
Deal found 8/14$197
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:05 amSAV - STL
1 stop4h 11mAmerican Airlines
Wed 10/86:25 amSTL - SAV
1 stop4h 40mAmerican Airlines
Deal found 8/14$199
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/710:52 amCAE - STL
1 stop6h 11mAmerican Airlines
Sat 10/117:23 amSTL - CAE
1 stop5h 42mAmerican Airlines
Deal found 8/15$211
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/112:15 pmSAV - STL
1 stop4h 50mDelta
Sat 10/43:55 pmSTL - SAV
1 stop4h 30mDelta
Deal found 8/14$213
This Delta deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/235:40 amCAE - STL
1 stop3h 34mDelta
Sat 9/276:01 amSTL - CAE
1 stop5h 11mDelta
Deal found 8/15$217
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/15:08 pmSAV - STL
1 stop5h 02mAmerican Airlines
Sat 10/47:23 amSTL - SAV
2 stops6h 30mAmerican Airlines
Deal found 8/14$218
This Frontier deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/111:11 pmCLT - STL
2 stops20h 55mFrontier
Sun 9/1410:39 amSTL - CLT
2 stops20h 16mFrontier
Deal found 8/15$222
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/410:45 amGSP - STL
1 stop4h 05mSouthwest
Wed 9/101:35 pmSTL - GSP
1 stop3h 30mSouthwest
Deal found 8/14$223
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:35 amCHS - STL
1 stop4h 40mSouthwest
Tue 9/1610:30 amSTL - CHS
2 stops6h 30mSouthwest
Deal found 8/14$223

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2025.
Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.

Fly from

South Carolina

Fly to

St. Louis

Route

Depart

Return

Price

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Fri 9/19

4:22 pm-9:10 pm

1 stop5h 48m

Lambert-St Louis

Sun 9/21

6:00 am-2:28 pm

1 stop7h 28m

$187

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Sat 9/27

6:27 am-9:16 am

1 stop3h 49m

Lambert-St Louis

Mon 9/29

8:23 am-1:39 pm

1 stop4h 16m

$187

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Sat 9/20

10:57 am-4:15 pm

1 stop6h 18m

Lambert-St Louis

Mon 9/22

6:05 am-11:19 am

1 stop4h 14m

$187

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Thu 10/16

8:20 pm-11:58 pm

1 stop4h 38m

Lambert-St Louis

Tue 10/21

6:00 am-2:11 pm

1 stop7h 11m

$193

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sun 10/5

5:15 am-8:05 am

1 stop3h 50m

Lambert-St Louis

Mon 10/6

5:30 am-10:26 am

1 stop3h 56m

$193

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 9/5

3:59 pm-9:06 pm

1 stop6h 07m

Lambert-St Louis

Mon 9/8

6:00 am-2:29 pm

1 stop7h 29m

$193

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Sat 11/15

5:10 am-8:08 am

1 stop3h 58m

Lambert-St Louis

Mon 11/17

6:00 am-1:17 pm

1 stop6h 17m

$197

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Thu 9/25

4:30 pm-7:20 pm

1 stop3h 50m

Lambert-St Louis

Mon 9/29

6:00 am-2:28 pm

1 stop7h 28m

$197

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Wed 9/10

4:22 pm-9:10 pm

1 stop5h 48m

Lambert-St Louis

Tue 9/16

8:17 am-1:39 pm

1 stop4h 22m

$197

SavannahSt. Louis

SAV - STL

SAVSTL

Savannah/Hilton Head

Wed 10/1

6:05 am-9:16 am

1 stop4h 11m

Lambert-St Louis

Wed 10/8

6:25 am-12:05 pm

1 stop4h 40m

$199

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/15

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to St. Louis

What is the cheapest month to book a flight from South Carolina to St. Louis?

Currently, August is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $311). Flying from South Carolina to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to STL?

Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 16, 2025.

When flying from South Carolina to St. Louis, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from South Carolina?

    For a flight from South Carolina to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • How popular is this South Carolina to St. Louis flight route?

    Within the past month, 6 users have taken a look at flights from South Carolina to Lambert-St Louis.

  • What are the cheapest airlines to fly from South Carolina to St. Louis one-way?

    To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $73. Spirit Airlines flights start at $89 while deals on Southwest start at $92 one-way.

  • What are the most popular routes from South Carolina to St. Louis?

    The most popular flight routes from South Carolina to St. Louis are Charlotte Douglas - Lambert-St Louis, Charleston - Lambert-St Louis and Myrtle Beach Intl - Lambert-St Louis.

  • What are the cheapest flights from South Carolina to St. Louis?

    On average you can expect to pay $355 for a flight from South Carolina to St. Louis. The cheapest flight overall is $198 while the most popular route, (Charlotte Douglas - Lambert-St Louis) is currently priced at $182.

  • Can I find deals for flights from South Carolina to St. Louis that include hotel bookings?

    Yes. In addition to deals on South Carolina to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to St. Louis.

  • Can I find deals for business class flights from South Carolina to St. Louis?

    Yes. Cheapflights offers flight deals from South Carolina to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $311). Flying from South Carolina to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
St. Peters
Glencoe
Alton
Chesterfield
Farmington
Festus

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Top 3 airlines flying from South Carolina to St. Louis

Discover the top 3 airlines that operate flights from South Carolina to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$172Average$373FlexibilityNo cancel feeOn-time71%
DeltaCheapest$196Average$367FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$286Average$362FlexibilityNo cancel feeOn-time63%

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