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St. Louis

$61+ Cheap flights from South Carolina to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/4. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
dic. 4 — dic. 111
jue. 12/4
jue. 12/11
1 adult, Economy
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Find flight deals from South Carolina to St. Louis

Cheapest flights from South Carolina to St. Louis
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on noviembre 4, 2025.

This CheapOair deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/89:20 pmCLT - STL
1 stop26h 13mFrontier
jue. 12/113:30 pmSTL - CLT
1 stop5h 08mFrontier
Deal found 11/3$120
This CheapOair deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/251:54 pmCLT - STL
1 stop20h 35mFrontier
jue. 11/274:13 pmSTL - CLT
1 stop15h 26mFrontier
Deal found 11/4$148
This Mytrip deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/182:27 pmCLT - STL
1 stop20h 38mMultiple Airlines
sáb. 11/229:52 amSTL - CLT
1 stop5h 58mMultiple Airlines
Deal found 11/3$165
This Mytrip deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/106:07 pmCLT - STL
1 stop16h 00mFrontier
jue. 11/137:45 pmSTL - CLT
1 stop20h 32mFrontier
Deal found 11/3$199
This Frontier deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/1410:33 pmCLT - STL
1 stop11h 26mFrontier
lun. 12/229:07 amSTL - CLT
1 stop6h 54mFrontier
Deal found 11/3$200
This Booking.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/55:44 pmCLT - STL
1 stop17h 30mFrontier
dom. 12/79:54 amSTL - CLT
1 stop22h 43mFrontier
Deal found 11/2$202
This Booking.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/510:33 pmCLT - STL
1 stop25h 00mMultiple Airlines
dom. 12/72:47 pmSTL - CLT
1 stop8h 12mMultiple Airlines
Deal found 11/3$207
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/42:59 pmCHS - STL
1 stop8h 34mMultiple Airlines
lun. 12/83:30 pmSTL - CHS
1 stop16h 07mMultiple Airlines
Deal found 11/2$208
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/134:22 pmCLT - STL
2 stops18h 25mMultiple Airlines
lun. 12/159:54 amSTL - CLT
1 stop9h 06mMultiple Airlines
Deal found 11/3$214
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/109:58 pmCLT - STL
Nonstop2h 08mAmerican Airlines
mié. 12/1710:13 amSTL - CLT
Nonstop1h 53mAmerican Airlines
Deal found 11/3$217
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/188:28 amSAV - STL
2 stops39h 33mMultiple Airlines
dom. 11/2311:08 amSTL - SAV
1 stop10h 58mMultiple Airlines
Deal found 11/2$217
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/198:28 amSAV - STL
2 stops31h 01mMultiple Airlines
dom. 11/2311:08 amSTL - SAV
1 stop10h 58mMultiple Airlines
Deal found 11/2$219

Cheap flight deals from South Carolina to St. Louis

Keep the following information in mind while searching for South Carolina to St. Louis flight deals. Data was last updated noviembre 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$119
(Mytrip)

One-way from

$61
(Frontier)

Popular in

February

Cheapest in

August

Average price

$324
Provider with most accurate pricing for Myrtle Beach Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Lambert-St Louis flights.
Search Deals
From South Carolina to Lambert-St Louis
Search Deals
One-way flight from South Carolina to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($29 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 4, 2025.
Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.

Fly from

South Carolina

Fly to

St. Louis

Route

Depart

Return

Price

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

jue. 12/4

2:59 pm-8:59 am

1 stop19h 00m

Lambert-St Louis

lun. 12/8

10:47 am-8:37 am

2 stops20h 50m

$209

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

mié. 2/4

5:35 am-8:53 am

1 stop4h 18m

Lambert-St Louis

mié. 2/11

1:05 pm-9:28 pm

1 stop7h 23m

$211

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

mié. 2/18

7:00 am-12:25 pm

1 stop6h 25m

Lambert-St Louis

sáb. 2/21

7:25 am-3:42 pm

1 stop7h 17m

$211

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

mié. 2/4

9:10 am-5:43 pm

2 stops9h 33m

Lambert-St Louis

mié. 2/11

8:05 am-2:00 pm

1 stop4h 55m

$216

SavannahSt. Louis

SAV - STL

SAVSTL

Savannah/Hilton Head

mar. 11/18

8:28 am-11:01 pm

2 stops39h 33m

Lambert-St Louis

dom. 11/23

11:08 am-11:06 pm

1 stop10h 58m

$217

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

mié. 2/4

11:59 am-6:14 pm

2 stops7h 15m

Lambert-St Louis

mié. 2/11

9:54 am-5:07 pm

2 stops6h 13m

$221

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

mar. 11/25

10:11 am-4:07 pm

1 stop6h 56m

Lambert-St Louis

jue. 11/27

6:00 am-12:06 pm

1 stop5h 06m

$230

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

jue. 11/27

7:50 am-9:00 am

Nonstop2h 10m

Lambert-St Louis

jue. 12/4

2:55 pm-5:40 pm

Nonstop1h 45m

$231

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

sáb. 12/13

6:45 am-9:40 am

1 stop3h 55m

Lambert-St Louis

lun. 12/15

2:55 pm-5:40 pm

Nonstop1h 45m

$231

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

sáb. 12/27

9:15 pm-12:15 am

1 stop4h 00m

Lambert-St Louis

jue. 1/1

10:15 am-4:20 pm

1 stop5h 05m

$237

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/3

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to St. Louis

What is the cheapest month to book a flight from South Carolina to St. Louis?

Currently, June is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $108). Flying from South Carolina to St. Louis in April is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to STL?

Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated noviembre 4, 2025.

One of the essential ways to save on airfare from South Carolina to St. Louis is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 16% on airfare.

What is the cheapest day to fly from South Carolina to St. Louis?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to St. Louis. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to St. Louis flight should consider departing on Saturday mornings when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from South Carolina?

    For a flight from South Carolina to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • How popular is this South Carolina to St. Louis flight route?

    Within the past month, 9 users have taken a look at flights from South Carolina to Lambert-St Louis.

  • How long is the flight from South Carolina to St. Louis?

    Departing from South Carolina to St. Louis will take you 2h 10m. South Carolina and St. Louis are separated by a distance of 574 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to St. Louis one-way?

    To fly one-way, consider booking your trip with Southwest, which is currently one of the cheapest options available, starting at $91. Frontier flights start at $109 while deals on Spirit Airlines start at $123 one-way.

  • What are the most popular routes from South Carolina to St. Louis?

    The most popular flight routes from South Carolina to St. Louis are Charlotte Douglas - Lambert-St Louis, Charleston - Lambert-St Louis and Columbia Metropolitan - Lambert-St Louis.

  • Can I find deals for flights from South Carolina to St. Louis that include hotel bookings?

    Yes. In addition to deals on South Carolina to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to St. Louis.

  • Can I find deals for business class flights from South Carolina to St. Louis?

    Yes. Cheapflights offers flight deals from South Carolina to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to St. Louis?

    Currently, June is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $108). Flying from South Carolina to St. Louis in April is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

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Top 3 airlines flying from South Carolina to St. Louis

Discover the top 3 airlines that operate flights from South Carolina to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$168Average$362FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$243Average$372FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$287Average$407FlexibilityNo cancel feeOn-time63%

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