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St. Louis

$72+ Cheap flights from South Carolina to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
oct. 17 — oct. 241
vie. 10/17
vie. 10/24
1 adult, Economy
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Cheap flight deals from South Carolina to St. Louis

Keep the following information in mind while searching for South Carolina to St. Louis flight deals. Data was last updated septiembre 17, 2025.

Round-trip from

$159
(American Airlines)

One-way from

$72
(Cheapflightsfares)

Popular in

February

Cheapest in

August

Average price

$330

Good round-trip deal

$277 or less

Good one-way deal

$199 or less
From South Carolina to Lambert-St Louis
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One-way flight from South Carolina to Lambert-St Louis
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Highest demand for flights based on searches. 5% potential increase in price ($21 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($4 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from South Carolina to Lambert-St Louis.
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Price to beat on a one-way flight from South Carolina to Lambert-St Louis.
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Find flight deals from South Carolina to St. Louis

Cheapest flights from South Carolina to St. Louis
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/247:41 pmCHS - STL
1 stop4h 24mAmerican Airlines
mar. 10/287:00 amSTL - CHS
1 stop5h 36mAmerican Airlines
Deal found 9/15$159
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/229:30 amCHS - STL
1 stop4h 05mDelta
dom. 10/266:00 amSTL - CHS
1 stop7h 12mDelta
Deal found 9/14$197
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/188:05 pmCAE - STL
1 stop4h 53mAmerican Airlines
sáb. 10/257:23 amSTL - CAE
1 stop5h 42mAmerican Airlines
Deal found 9/17$212
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/226:30 amCLT - STL
1 stop5h 19mUnited Airlines
mié. 10/223:23 pmSTL - CLT
1 stop5h 18mUnited Airlines
Deal found 9/15$217
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/187:20 amCAE - STL
1 stop6h 15mDelta
sáb. 10/257:05 amSTL - CAE
1 stop6h 13mDelta
Deal found 9/17$217
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/305:08 pmCHS - STL
2 stops23h 49mMultiple Airlines
dom. 11/210:57 amSTL - CHS
1 stop21h 04mMultiple Airlines
Deal found 9/15$220
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/157:05 amCLT - STL
1 stop5h 40mSouthwest
mié. 10/2210:05 amSTL - CLT
2 stops6h 30mSouthwest
Deal found 9/15$222
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/1110:19 amCLT - STL
1 stop8h 51mMultiple Airlines
mar. 10/147:52 pmSTL - CLT
2 stops37h 03mMultiple Airlines
Deal found 9/15$226
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/256:33 amCLT - STL
1 stop5h 16mDelta
mar. 12/27:05 amSTL - CLT
1 stop5h 21mDelta
Deal found 9/15$227
This Frontier deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/32:01 pmCLT - STL
2 stops20h 05mFrontier
lun. 10/69:32 pmSTL - CLT
2 stops15h 18mFrontier
Deal found 9/16$230
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/114:20 pmCLT - STL
1 stop5h 00mSouthwest
mar. 10/146:40 pmSTL - CLT
Nonstop1h 50mSouthwest
Deal found 9/15$231
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/154:20 pmCLT - STL
1 stop6h 45mSouthwest
lun. 10/272:05 pmSTL - CLT
2 stops8h 15mSouthwest
Deal found 9/15$232

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.

Fly from

South Carolina

Fly to

St. Louis

Route

Depart

Return

Price

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

mié. 10/22

9:30 am-12:35 pm

1 stop4h 05m

Lambert-St Louis

dom. 10/26

6:00 am-2:12 pm

1 stop7h 12m

$197

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

mar. 12/16

8:00 am-1:00 pm

1 stop6h 00m

Lambert-St Louis

mar. 12/16

5:12 pm-11:57 pm

1 stop5h 45m

$197

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

jue. 10/30

5:35 am-10:26 am

1 stop5h 51m

Lambert-St Louis

dom. 11/2

5:00 am-10:46 am

1 stop4h 46m

$197

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

mié. 10/22

7:05 am-11:45 am

1 stop5h 40m

Lambert-St Louis

mié. 10/22

6:40 pm-9:30 pm

Nonstop1h 50m

$217

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

sáb. 10/11

5:25 pm-8:33 pm

1 stop4h 08m

Lambert-St Louis

mar. 10/14

9:10 am-4:40 pm

1 stop6h 30m

$217

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

mié. 2/18

4:00 pm-8:57 pm

1 stop5h 57m

Lambert-St Louis

sáb. 2/21

6:00 am-3:07 pm

1 stop8h 07m

$217

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

sáb. 10/18

5:59 pm-11:54 pm

2 stops6h 55m

Lambert-St Louis

sáb. 10/25

6:00 am-2:05 pm

2 stops7h 05m

$223

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

mié. 10/15

6:45 am-10:26 am

1 stop4h 41m

Lambert-St Louis

lun. 10/27

2:15 pm-9:35 pm

1 stop6h 20m

$227

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

mar. 10/28

9:32 am-1:22 pm

1 stop4h 50m

Lambert-St Louis

jue. 10/30

6:00 am-11:00 am

1 stop4h 00m

$227

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

vie. 10/24

3:50 pm-4:50 pm

Nonstop2h 00m

Lambert-St Louis

lun. 10/27

4:35 pm-7:25 pm

Nonstop1h 50m

$231

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to St. Louis

What is the cheapest month to book a flight from South Carolina to St. Louis?

Currently, August is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $311). Flying from South Carolina to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to STL?

Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 17, 2025.

When flying from South Carolina to St. Louis, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from South Carolina?

    For a flight from South Carolina to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • How popular is this South Carolina to St. Louis flight route?

    Within the past month, 9 users have taken a look at flights from South Carolina to Lambert-St Louis.

  • How long is the flight from South Carolina to St. Louis?

    Departing from South Carolina to St. Louis will take you 4h 05m. South Carolina and St. Louis are separated by a distance of 705 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to St. Louis one-way?

    To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $76. Frontier flights start at $82 while deals on Southwest start at $99 one-way.

  • What are the most popular routes from South Carolina to St. Louis?

    The most popular flight routes from South Carolina to St. Louis are Charlotte Douglas - Lambert-St Louis, Charleston - Lambert-St Louis and Columbia Metropolitan - Lambert-St Louis.

  • What are the cheapest flights from South Carolina to St. Louis?

    On average you can expect to pay $366 for a flight from South Carolina to St. Louis. The cheapest flight overall is $159 while the most popular route, (Charlotte Douglas - Lambert-St Louis) is currently priced at $183.

  • Can I find deals for flights from South Carolina to St. Louis that include hotel bookings?

    Yes. In addition to deals on South Carolina to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to St. Louis.

  • Can I find deals for business class flights from South Carolina to St. Louis?

    Yes. Cheapflights offers flight deals from South Carolina to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $311). Flying from South Carolina to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

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Alternative routes for South Carolina to St. Louis

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Top 3 airlines flying from South Carolina to St. Louis

Discover the top 3 airlines that operate flights from South Carolina to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$168Average$366FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$243Average$373FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$286Average$370FlexibilityNo cancel feeOn-time63%

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