$97+ Cheap flights from South Carolina to St. Louis (STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Nov 1 — Nov 81
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to St. Louis
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Cheapest flights from South Carolina to St. LouisExplore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 2, 2026.
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 2, 2026.
This Southwest deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:15 am -
1 stop4h 00m
Mon 10/264:30 pm -
Nonstop1h 55m
Deal found 9/30![Southwest logo]()
$222
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
1 stop5h 51m
Mon 10/262:25 pm -
1 stop5h 33m
Deal found 9/30![Delta logo]()
$227
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
2 stops7h 15m
Mon 10/267:30 am -
1 stop5h 26m
Deal found 9/30![United Airlines logo]()
$232
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:35 am -
2 stops8h 10m
Wed 12/210:15 am -
2 stops8h 50m
Deal found 9/29![Southwest logo]()
$237
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:46 pm -
1 stop4h 35m
Wed 10/217:30 am -
1 stop6h 31m
Deal found 9/29![United Airlines logo]()
$254
This Southwest deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:50 pm -
1 stop8h 00m
Mon 10/264:30 pm -
Nonstop1h 55m
Deal found 9/30![Southwest logo]()
$261
This Southwest deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:40 pm -
1 stop4h 00m
Tue 11/310:55 am -
2 stops7h 55m
Deal found 9/30![Southwest logo]()
$264
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:08 pm -
1 stop7h 06m
Fri 11/275:00 am -
1 stop4h 35m
Deal found 9/30![American Airlines logo]()
$266
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:05 am -
2 stops7h 40m
Sat 12/55:45 am -
2 stops5h 30m
Deal found 9/27![Southwest logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:00 pm -
2 stops27h 40m
Mon 10/194:30 pm -
1 stop21h 08m
Deal found 9/30![Multiple Airlines logo]()
$271
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:25 pm -
1 stop7h 17m
Tue 11/37:00 am -
1 stop6h 56m
Deal found 9/30![American Airlines logo]()
$287
This Southwest deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:10 pm -
2 stops5h 55m
Tue 11/312:40 pm -
1 stop6h 10m
Deal found 9/30![Southwest logo]()
$288
Best flights from South Carolina to St. LouisDiscover carefully curated flight deals from South Carolina to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 2, 2026.
Discover carefully curated flight deals from South Carolina to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 2, 2026.
This United Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
2 stops7h 15m
Mon 10/267:30 am -
1 stop5h 26m
Deal found 10/1![United Airlines logo]()
$232
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:05 am -
2 stops7h 40m
Sat 12/57:00 am -
1 stop4h 15m
Deal found 9/27![Southwest logo]()
$264
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/215:15 am -
1 stop4h 52m
Mon 12/287:15 pm -
1 stop3h 39m
Deal found 9/29![Delta logo]()
$346
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1510:55 am -
1 stop6h 02m
Mon 10/195:00 am -
1 stop5h 05m
Deal found 9/29![American Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:52 pm -
2 stops7h 48m
Wed 11/45:00 am -
1 stop5h 21m
Deal found 9/30![United Airlines logo]()
$232
This Southwest deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:10 pm -
2 stops5h 55m
Tue 11/310:55 am -
2 stops6h 15m
Deal found 9/30![Southwest logo]()
$293
This United Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:00 pm -
1 stop5h 24m
Mon 11/96:00 am -
2 stops7h 28m
Deal found 10/1![United Airlines logo]()
$271
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:40 pm -
1 stop4h 00m
Wed 10/214:30 pm -
1 stop3h 35m
Deal found 9/28![Southwest logo]()
$315
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:10 pm -
1 stop5h 32m
Tue 11/1712:29 pm -
1 stop4h 50m
Deal found 10/2![Delta logo]()
$375
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1112:02 pm -
1 stop6h 27m
Sat 11/142:54 pm -
1 stop6h 40m
Deal found 9/29![American Airlines logo]()
$377
This United Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:28 pm -
1 stop8h 24m
Sat 10/317:30 am -
2 stops10h 42m
Deal found 10/1![United Airlines logo]()
$332
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:19 pm -
1 stop5h 37m
Wed 11/1812:29 pm -
1 stop4h 50m
Deal found 10/2![Delta logo]()
$375
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:12 am -
2 stops11h 28m
Wed 10/286:00 am -
2 stops7h 38m
Deal found 9/30![United Airlines logo]()
$337
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:13 pm -
1 stop6h 46m
Wed 10/219:27 am -
1 stop7h 11m
Deal found 9/30![American Airlines logo]()
$412
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:40 am -
1 stop6h 35m
Mon 11/165:30 pm -
1 stop5h 23m
Deal found 10/2![Delta logo]()
$375
This Southwest deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1010:45 am -
2 stops9h 40m
Thu 11/121:20 pm -
1 stop6h 00m
Deal found 10/1![Southwest logo]()
$382
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:13 pm -
1 stop6h 46m
Sun 10/257:16 am -
1 stop6h 10m
Deal found 10/1![American Airlines logo]()
$412
This Delta deal was found by Cheapflights users on 10/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:40 am -
1 stop6h 35m
Sat 11/2110:13 am -
1 stop4h 28m
Deal found 10/2![Delta logo]()
$375
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:35 am -
1 stop6h 25m
Sun 10/255:25 pm -
Nonstop1h 55m
Deal found 9/27![Southwest logo]()
$385
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/132:00 pm -
1 stop9h 25m
Sun 11/1510:30 am -
1 stop4h 20m
Deal found 9/29![Southwest logo]()
$385
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/1211:28 am -
2 stops11h 19m
Wed 1/138:05 am -
2 stops7h 44m
Deal found 9/29![United Airlines logo]()
$387
This Delta deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:40 am -
1 stop6h 11m
Sat 10/176:00 am -
1 stop3h 48m
Deal found 10/1![Delta logo]()
$387
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/93:25 pm -
2 stops7h 30m
Thu 12/107:05 am -
2 stops10h 20m
Deal found 9/29![Southwest logo]()
$387
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:59 pm -
1 stop4h 24m
Sun 10/256:00 am -
1 stop3h 43m
Deal found 9/27![Delta logo]()
$388
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:37 pm -
1 stop5h 03m
Fri 10/301:08 pm -
2 stops8h 52m
Deal found 9/28![United Airlines logo]()
$392
This American Airlines deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:30 am -
1 stop6h 39m
Sun 10/1811:21 am -
2 stops7h 06m
Deal found 10/1![American Airlines logo]()
$484
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:25 pm -
2 stops7h 35m
Sat 11/148:45 am -
2 stops7h 35m
Deal found 9/29![Southwest logo]()
$387
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/142:11 pm -
2 stops7h 46m
Sun 10/185:00 am -
2 stops7h 31m
Deal found 9/29![American Airlines logo]()
$489
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:37 pm -
1 stop6h 47m
Wed 11/41:00 pm -
1 stop5h 08m
Deal found 9/29![United Airlines logo]()
$425
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/73:25 pm -
2 stops7h 30m
Tue 12/87:05 am -
2 stops10h 20m
Deal found 9/29![Southwest logo]()
$387
Last-minute flights from South Carolina to St. LouisDiscover last-minute flight deals from South Carolina to St. Louis. Data last updated October 2, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to St. Louis. Data last updated October 2, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:00 pm -
2 stops27h 40m
Mon 10/194:30 pm -
1 stop21h 08m
Deal found 9/30![Multiple Airlines logo]()
$271
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:46 pm -
1 stop4h 35m
Wed 10/217:30 am -
1 stop6h 31m
Deal found 9/29![United Airlines logo]()
$254
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:00 am -
1 stop4h 20m
Wed 10/2112:25 pm -
2 stops7h 40m
Deal found 9/29![Southwest logo]()
$292
This Southwest deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:40 pm -
1 stop4h 00m
Tue 11/310:55 am -
2 stops7h 55m
Deal found 9/30![Southwest logo]()
$264
This Southwest deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:50 pm -
1 stop8h 00m
Mon 10/264:30 pm -
Nonstop1h 55m
Deal found 9/30![Southwest logo]()
$261
This Southwest deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:15 am -
1 stop4h 00m
Mon 10/264:30 pm -
Nonstop1h 55m
Deal found 9/30![Southwest logo]()
$222
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
1 stop5h 51m
Mon 10/262:25 pm -
1 stop5h 33m
Deal found 9/30![Delta logo]()
$227
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
2 stops7h 15m
Mon 10/267:30 am -
1 stop5h 26m
Deal found 9/30![United Airlines logo]()
$232
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:25 pm -
1 stop7h 17m
Tue 11/37:00 am -
1 stop6h 56m
Deal found 9/30![American Airlines logo]()
$287
This Southwest deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:10 pm -
2 stops5h 55m
Tue 11/312:40 pm -
1 stop6h 10m
Deal found 9/30![Southwest logo]()
$288
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:35 am -
2 stops8h 10m
Wed 12/210:15 am -
2 stops8h 50m
Deal found 9/29![Southwest logo]()
$237
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:08 pm -
1 stop7h 06m
Fri 11/275:00 am -
1 stop4h 35m
Deal found 9/30![American Airlines logo]()
$266
One-way flights from South Carolina to St. LouisSearch for one-way flight options from South Carolina to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 2, 2026.
Search for one-way flight options from South Carolina to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/273:00 pm -
2 stops27h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Multiple Airlines logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/203:18 pm -
2 stops27h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Multiple Airlines logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:00 pm -
2 stops27h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:00 am -
2 stops12h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![Multiple Airlines logo]()
$108
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:25 pm -
Nonstop2h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Southwest logo]()
$109
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/272:05 pm -
1 stop5h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Delta logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:21 pm -
2 stops22h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Multiple Airlines logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/274:03 pm -
2 stops26h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Multiple Airlines logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/18:15 pm -
2 stops22h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![Multiple Airlines logo]()
$128
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am -
1 stop7h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![United Airlines logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/14:03 pm -
2 stops20h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Multiple Airlines logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:10 pm -
2 stops22h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Multiple Airlines logo]()
$149
Find flight deals from South Carolina to St. Louis
Keep the following information in mind while searching for South Carolina to St. Louis flight deals. Data was last updated October 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $222 (Southwest) |
One-way from | $97 (Kiwi.com) |
Popular in | June |
Cheapest in | February |
Average price | $322 |
Good round-trip deal | $301 or less |
Good one-way deal | $321 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 2, 2026.
Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Wed 10/21
8:10 am-11:35 am
1 stop4h 25m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$109
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Wed 10/28
2:05 pm-6:15 pm
1 stop5h 10m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$114
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Mon 10/26
8:08 pm-11:59 pm
1 stop4h 51m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$114
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Wed 12/2
5:10 am-9:01 am
1 stop4h 51m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$114
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Tue 12/29
7:59 pm-11:55 pm
1 stop4h 56m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$114
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Wed 12/30
7:59 pm-11:55 pm
1 stop4h 56m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$114
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Sat 10/24
6:00 am-10:51 am
1 stop5h 51m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$114
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Thu 10/29
7:50 am-1:20 pm
1 stop6h 30m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$114
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Thu 10/22
6:00 am-12:13 pm
2 stops7h 13m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$119
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Sat 11/7
6:00 am-12:12 pm
1 stop7h 12m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$130
Showing 1-10 of 59 resultsSorted by cheapest first
Best time to book a flight from South Carolina to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.
CHS-STL
GSP-STL
MYR-STL
CAE-STL
HHH-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to St. Louis
USSC-STL
CHS-STL
GSP-STL
MYR-STL
CAE-STL
What is the cheapest month to book a flight from South Carolina to St. Louis?
Currently, February is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $346). Flying from South Carolina to St. Louis in December is currently the most expensive (average of $436). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to STL?
Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 2, 2026.
One of the essential ways to save on airfare from South Carolina to St. Louis is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 21% on airfare.
How much does it cost to fly round-trip from South Carolina to St. Louis?
Airfare is below average for this route at the moment.
South Carolina to St. Louis flights typically cost between $306 and $506 in October.The cheapest round-trip price found within the last 5 days was $222 on Southwest (Oct 24-Oct 26).
Related info for your journey
Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Wentzville
Chesterfield
Maryland Heights
Collinsville
Edwardsville
Glencoe
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for South Carolina to St. Louis
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Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to St. Louis by cabin class
Find flights from South Carolina to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and St. Louis flights
Browse other South Carolina and St. Louis flight options. Last updated on October 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 2, 2026.
South Carolina to St. Louis flights
Consider these flights traveling from South Carolina to St. Louis.
Top 3 airlines flying from South Carolina to St. Louis
Discover the top 3 airlines that operate flights from South Carolina to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$226 | Average$370 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$228 | Average$385 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$253 | Average$379 | FlexibilityNo cancel fee | On-time71% |