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St. Louis

$64+ Cheap flights from South Carolina to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Feb 4 — Feb 111
Wed 2/4
Wed 2/11
1 adult, Economy
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Cheap flight deals from South Carolina to St. Louis

Cheapest flights from South Carolina to St. Louis
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 5, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/296:01 pmCLT - STL
1 stop6h 32mMultiple Airlines
Sun 2/19:09 amSTL - CLT
1 stop24h 08mMultiple Airlines
Deal found 1/3$132
This Kiwi.com deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/307:06 pmCLT - STL
1 stop17h 05mMultiple Airlines
Sun 2/15:42 pmSTL - CLT
1 stop15h 35mMultiple Airlines
Deal found 1/3$143
This Frontier deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/319:59 pmCLT - STL
1 stop11h 25mFrontier
Mon 2/210:16 amSTL - CLT
1 stop7h 39mFrontier
Deal found 1/4$144
This Kiwi.com deal was found by Cheapflights users on 1/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/236:01 pmCLT - STL
1 stop6h 32mMultiple Airlines
Sun 1/255:42 pmSTL - CLT
1 stop14h 48mMultiple Airlines
Deal found 1/2$152
This Kiwi.com deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/69:59 pmCLT - STL
1 stop14h 12mFrontier
Sun 2/85:42 pmSTL - CLT
1 stop14h 48mFrontier
Deal found 1/4$154
This Frontier deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/226:54 pmCLT - STL
1 stop5h 39mFrontier
Mon 1/2610:16 amSTL - CLT
1 stop7h 39mFrontier
Deal found 1/3$160
This Kiwi.com deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/239:59 pmCLT - STL
1 stop14h 12mFrontier
Sun 1/255:42 pmSTL - CLT
1 stop14h 48mFrontier
Deal found 1/3$162
This Kiwi.com deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/233:21 pmCHS - STL
1 stop20h 50mMultiple Airlines
Mon 1/265:42 pmSTL - CHS
1 stop13h 56mMultiple Airlines
Deal found 1/4$163
This Kiwi.com deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/265:05 pmCHS - STL
2 stops31h 28mMultiple Airlines
Mon 2/210:16 amSTL - CHS
1 stop21h 22mMultiple Airlines
Deal found 1/4$182
This Kiwi.com deal was found by Cheapflights users on 1/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/291:07 pmMYR - STL
1 stop22h 16mMultiple Airlines
Sun 2/15:42 pmSTL - MYR
2 stops24h 38mMultiple Airlines
Deal found 1/3$232
This Delta deal was found by Cheapflights users on 1/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/17:00 amSAV - STL
1 stop4h 34mDelta
Mon 5/46:59 pmSTL - SAV
1 stop4h 00mDelta
Deal found 1/2$237
This Kiwi.com deal was found by Cheapflights users on 1/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/303:21 pmCHS - STL
1 stop9h 12mMultiple Airlines
Fri 2/611:18 amSTL - CHS
2 stops29h 21mMultiple Airlines
Deal found 1/2$237

Find flight deals from South Carolina to St. Louis

Keep the following information in mind while searching for South Carolina to St. Louis flight deals. Data was last updated January 5, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$132
(Kiwi.com)

One-way from

$64
(Frontier)

Popular in

January

Cheapest in

August

Average price

$537
Provider with most accurate pricing for Myrtle Beach Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Lambert-St Louis flights.
Search Deals
From South Carolina to Lambert-St Louis
Search Deals
One-way flight from South Carolina to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($92 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 5, 2026.
Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.

Fly from

South Carolina

Fly to

St. Louis

Route

Depart

Return

Price

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Thu 1/29

6:01 pm-11:33 pm

1 stop6h 32m

Lambert-St Louis

Sun 2/1

9:09 am-10:17 am

1 stop24h 08m

$132

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Fri 1/30

7:06 pm-11:11 am

1 stop17h 05m

Lambert-St Louis

Sun 2/1

5:42 pm-10:17 am

1 stop15h 35m

$143

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Thu 1/22

6:54 pm-11:33 pm

1 stop5h 39m

Lambert-St Louis

Mon 1/26

10:16 am-6:55 pm

1 stop7h 39m

$163

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Fri 2/27

5:49 pm-12:27 am

1 stop7h 38m

Lambert-St Louis

Sun 3/1

3:49 pm-6:18 pm

2 stops25h 29m

$182

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Mon 1/26

5:05 pm-11:33 pm

2 stops31h 28m

Lambert-St Louis

Mon 2/2

10:16 am-8:38 am

1 stop21h 22m

$182

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Sat 1/17

8:46 pm-9:11 am

1 stop13h 25m

Lambert-St Louis

Sun 1/18

5:11 pm-8:03 am

1 stop13h 52m

$199

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Sun 2/22

5:49 pm-1:09 pm

2 stops20h 20m

Lambert-St Louis

Wed 2/25

3:49 pm-10:17 am

1 stop17h 28m

$213

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Sat 1/31

7:00 am-9:45 am

1 stop3h 45m

Lambert-St Louis

Mon 2/2

2:30 pm-5:15 pm

Nonstop1h 45m

$231

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Thu 2/19

12:55 pm-7:00 pm

1 stop7h 05m

Lambert-St Louis

Sat 2/21

3:05 pm-5:50 pm

Nonstop1h 45m

$232

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 2/13

3:20 pm-12:27 am

1 stop10h 07m

Lambert-St Louis

Fri 2/20

3:49 pm-10:59 am

1 stop18h 10m

$232

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/3

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to St. Louis

What is the cheapest month to book a flight from South Carolina to St. Louis?

Currently, June is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $108). Flying from South Carolina to St. Louis in November is currently the most expensive (average of $292). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to STL?

Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 5, 2026.

One of the essential ways to save on airfare from South Carolina to St. Louis is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 23% on airfare.

What is the cheapest day to fly from South Carolina to St. Louis?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to St. Louis. Price data was last updated on December 27, 2025.

Travelers seeking maximum savings on their South Carolina to St. Louis flight should consider departing on Saturday mornings when fares are most often at their lowest. Tuesday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from South Carolina?

    For a flight from South Carolina to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

  • How popular is this South Carolina to St. Louis flight route?

    Within the past month, 9 users have taken a look at flights from South Carolina to Lambert-St Louis.

  • How long is the flight from South Carolina to St. Louis?

    Departing from South Carolina to St. Louis will take you 4h. South Carolina and St. Louis are separated by a distance of 689 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from South Carolina to St. Louis one-way?

    To fly one-way, consider booking your trip with Volaris, which is currently one of the cheapest options available, starting at $124. Frontier flights start at $164 while deals on Delta start at $193 one-way.

  • What are the most popular routes from South Carolina to St. Louis?

    The most popular flight routes from South Carolina to St. Louis are Charlotte Douglas - Lambert-St Louis, Greenville - Lambert-St Louis and Charleston - Lambert-St Louis.

  • Can I find deals for flights from South Carolina to St. Louis that include hotel bookings?

    Yes. In addition to deals on South Carolina to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to St. Louis.

  • Can I find deals for business class flights from South Carolina to St. Louis?

    Yes. Cheapflights offers flight deals from South Carolina to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to St. Louis?

    Currently, June is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $108). Flying from South Carolina to St. Louis in November is currently the most expensive (average of $292). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
Chesterfield
Alton
Farmington
Festus

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Alternative routes for South Carolina to St. Louis

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Top 3 airlines flying from South Carolina to St. Louis

Discover the top 3 airlines that operate flights from South Carolina to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$196Average$363FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$229Average$397FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$287Average$377FlexibilityNo cancel feeOn-time63%

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