$80+ Cheap flights from South Carolina to St. Louis (STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/8. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Apr 10 — Apr 171
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to St. LouisExplore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.
This Priceline deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/84:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Mon 4/134:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Deal found 3/8![Frontier logo]()
$160
This CheapOair deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:30 pm
CLT
- STL
1 stop26h 02m
Frontier
Sun 4/264:59 pm
STL
- CLT
1 stop15h 28m
Frontier
Deal found 3/7![Frontier logo]()
$170
This CheapOair deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Thu 4/234:59 pm
STL
- CLT
1 stop16h 13m
Frontier
Deal found 3/9![Frontier logo]()
$171
This Expedia deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:30 pm
CLT
- STL
1 stop26h 02m
Frontier
Sun 4/194:59 pm
STL
- CLT
1 stop15h 38m
Frontier
Deal found 3/8![Frontier logo]()
$181
This Mytrip deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1010:49 pm
CLT
- STL
1 stop10h 02m
Frontier
Fri 4/178:06 pm
STL
- CLT
1 stop19h 50m
Frontier
Deal found 3/11![Frontier logo]()
$189
This CheapOair deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Sat 4/254:59 pm
STL
- CLT
1 stop13h 06m
Frontier
Deal found 3/9![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Tue 5/54:55 pm
STL
- CLT
1 stop22h 40m
Frontier
Deal found 3/8![Frontier logo]()
$192
This Frontier deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/311:59 pm
CLT
- STL
1 stop10h 20m
Frontier
Mon 4/64:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Deal found 3/9![Frontier logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:30 pm
CLT
- STL
1 stop26h 02m
Frontier
Fri 5/88:12 pm
STL
- CLT
1 stop19h 40m
Frontier
Deal found 3/8![Frontier logo]()
$197
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:00 am
CHS
- STL
1 stop4h 04m
American Airlines
Sat 8/83:33 pm
STL
- CHS
1 stop7h 05m
American Airlines
Deal found 3/7![American Airlines logo]()
$199
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/47:30 am
CLT
- STL
Nonstop2h 05m
American Airlines
Sat 4/116:53 pm
STL
- CLT
Nonstop1h 57m
American Airlines
Deal found 3/7![American Airlines logo]()
$200
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:34 am
CHS
- STL
1 stop7h 09m
American Airlines
Wed 4/81:29 pm
STL
- CHS
1 stop7h 57m
American Airlines
Deal found 3/11![American Airlines logo]()
$227
Best flights from South Carolina to St. LouisDiscover carefully curated flight deals from South Carolina to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 11, 2026.
Discover carefully curated flight deals from South Carolina to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 11, 2026.
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/51:45 pm
CLT
- STL
2 stops9h 15m
Southwest
Tue 5/1211:35 am
STL
- CLT
2 stops8h 10m
Southwest
Deal found 3/11![Southwest logo]()
$227
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:28 pm
CLT
- STL
1 stop6h 43m
United Airlines
Wed 4/89:10 am
STL
- CLT
2 stops8h 34m
United Airlines
Deal found 3/6![United Airlines logo]()
$244
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:46 am
CLT
- STL
1 stop4h 48m
Delta
Wed 5/136:45 am
STL
- CLT
1 stop4h 29m
Delta
Deal found 3/11![Delta logo]()
$259
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/35:40 am
SAV
- STL
1 stop7h 07m
American Airlines
Sat 5/99:34 am
STL
- SAV
1 stop8h 11m
American Airlines
Deal found 3/7![American Airlines logo]()
$286
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:40 am
CLT
- STL
2 stops7h 20m
Southwest
Sat 4/252:25 pm
STL
- CLT
1 stop5h 50m
Southwest
Deal found 3/9![Southwest logo]()
$233
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/181:59 pm
CAE
- STL
1 stop6h 12m
Delta
Sun 4/196:00 am
STL
- CAE
1 stop6h 14m
Delta
Deal found 3/9![Delta logo]()
$260
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/253:50 pm
CLT
- STL
1 stop4h 20m
Southwest
Sun 4/2611:40 am
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 3/8![Southwest logo]()
$242
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/299:36 am
CLT
- STL
1 stop4h 29m
Delta
Sun 5/36:50 pm
STL
- CLT
1 stop4h 03m
Delta
Deal found 3/7![Delta logo]()
$261
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:30 am
CLT
- STL
Nonstop2h 05m
American Airlines
Sat 3/287:05 am
STL
- CLT
Nonstop1h 59m
American Airlines
Deal found 3/6![American Airlines logo]()
$296
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/129:40 am
CHS
- STL
1 stop7h 59m
United Airlines
Wed 5/137:45 am
STL
- CHS
1 stop5h 06m
United Airlines
Deal found 3/9![United Airlines logo]()
$302
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:15 pm
CHS
- STL
1 stop3h 45m
Southwest
Fri 5/294:00 pm
STL
- CHS
1 stop4h 30m
Southwest
Deal found 3/10![Southwest logo]()
$264
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:30 am
CLT
- STL
1 stop4h 00m
Delta
Sat 4/251:03 pm
STL
- CLT
1 stop4h 08m
Delta
Deal found 3/8![Delta logo]()
$267
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/254:10 pm
HHH
- STL
1 stop6h 15m
American Airlines
Tue 4/287:00 am
STL
- HHH
1 stop4h 37m
American Airlines
Deal found 3/11![American Airlines logo]()
$305
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:45 am
SAV
- STL
1 stop5h 46m
United Airlines
Sat 4/188:21 am
STL
- SAV
2 stops9h 58m
United Airlines
Deal found 3/6![United Airlines logo]()
$312
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:00 pm
SAV
- STL
1 stop6h 10m
Southwest
Sat 4/253:10 pm
STL
- SAV
Nonstop1h 50m
Southwest
Deal found 3/8![Southwest logo]()
$275
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/254:10 pm
HHH
- STL
1 stop6h 15m
American Airlines
Mon 4/277:05 am
STL
- HHH
2 stops8h 29m
American Airlines
Deal found 3/11![American Airlines logo]()
$310
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2911:09 am
CLT
- STL
2 stops11h 04m
United Airlines
Tue 5/59:21 am
STL
- CLT
2 stops10h 48m
United Airlines
Deal found 3/8![United Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:30 am
CHS
- STL
1 stop3h 37m
Delta
Sun 6/285:30 pm
STL
- CHS
1 stop4h 26m
Delta
Deal found 3/6![Delta logo]()
$297
This Southwest deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:10 am
CLT
- STL
2 stops7h 30m
Southwest
Wed 4/811:35 am
STL
- CLT
2 stops8h 10m
Southwest
Deal found 3/6![Southwest logo]()
$281
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:41 pm
GSP
- STL
1 stop4h 32m
United Airlines
Sat 4/116:30 am
STL
- GSP
2 stops11h 29m
United Airlines
Deal found 3/6![United Airlines logo]()
$324
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/265:40 am
CAE
- STL
1 stop3h 27m
Delta
Sun 6/286:00 am
STL
- CAE
1 stop4h 17m
Delta
Deal found 3/10![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/175:20 am
FLO
- STL
1 stop4h 10m
American Airlines
Mon 4/202:12 pm
STL
- FLO
1 stop6h 35m
American Airlines
Deal found 3/11![American Airlines logo]()
$341
This Southwest deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:30 pm
CLT
- STL
1 stop3h 45m
Southwest
Sun 4/2611:40 am
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 3/6![Southwest logo]()
$293
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:35 am
CLT
- STL
1 stop3h 35m
Delta
Sun 5/176:45 am
STL
- CLT
1 stop4h 29m
Delta
Deal found 3/11![Delta logo]()
$314
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/313:15 pm
MYR
- STL
1 stop6h 53m
United Airlines
Sun 4/266:30 am
STL
- MYR
1 stop6h 47m
United Airlines
Deal found 3/6![United Airlines logo]()
$346
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:15 am
CHS
- STL
2 stops9h 15m
Southwest
Fri 4/34:55 pm
STL
- CHS
1 stop3h 45m
Southwest
Deal found 3/8![Southwest logo]()
$293
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/84:40 pm
AGS
- STL
2 stops6h 27m
American Airlines
Sat 4/116:53 pm
STL
- AGS
1 stop4h 05m
American Airlines
Deal found 3/8![American Airlines logo]()
$356
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/156:00 am
SAV
- STL
1 stop7h 27m
United Airlines
Fri 3/203:24 pm
STL
- SAV
1 stop4h 49m
United Airlines
Deal found 3/6![United Airlines logo]()
$347
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:34 am
CAE
- STL
1 stop4h 31m
Delta
Sun 3/296:00 am
STL
- CAE
1 stop6h 27m
Delta
Deal found 3/9![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:08 pm
AGS
- STL
1 stop6h 51m
American Airlines
Sun 5/105:51 am
STL
- AGS
2 stops7h 47m
American Airlines
Deal found 3/11![American Airlines logo]()
$356
Last-minute flights from South Carolina to St. LouisDiscover last-minute flight deals from South Carolina to St. Louis. Data last updated March 11, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to St. Louis. Data last updated March 11, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/311:59 pm
CLT
- STL
1 stop10h 20m
Frontier
Mon 4/64:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Deal found 3/9![Frontier logo]()
$195
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/47:30 am
CLT
- STL
Nonstop2h 05m
American Airlines
Sat 4/116:53 pm
STL
- CLT
Nonstop1h 57m
American Airlines
Deal found 3/7![American Airlines logo]()
$200
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:55 pm
CHS
- STL
1 stop4h 10m
Southwest
Mon 4/132:10 pm
STL
- CHS
Nonstop1h 55m
Southwest
Deal found 3/7![Southwest logo]()
$255
This Priceline deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/84:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Mon 4/134:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Deal found 3/8![Frontier logo]()
$160
This Mytrip deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1010:49 pm
CLT
- STL
1 stop10h 02m
Frontier
Fri 4/178:06 pm
STL
- CLT
1 stop19h 50m
Frontier
Deal found 3/11![Frontier logo]()
$189
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:00 am
CAE
- STL
1 stop4h 30m
American Airlines
Sat 4/185:20 am
STL
- CAE
1 stop5h 38m
American Airlines
Deal found 3/9![American Airlines logo]()
$232
This Expedia deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:30 pm
CLT
- STL
1 stop26h 02m
Frontier
Sun 4/194:59 pm
STL
- CLT
1 stop15h 38m
Frontier
Deal found 3/8![Frontier logo]()
$181
This CheapOair deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Thu 4/234:59 pm
STL
- CLT
1 stop16h 13m
Frontier
Deal found 3/9![Frontier logo]()
$171
This CheapOair deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Sat 4/254:59 pm
STL
- CLT
1 stop13h 06m
Frontier
Deal found 3/9![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:30 pm
CLT
- STL
1 stop26h 02m
Frontier
Sun 4/264:59 pm
STL
- CLT
1 stop15h 28m
Frontier
Deal found 3/7![Frontier logo]()
$170
This CheapOair deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Tue 5/54:55 pm
STL
- CLT
1 stop22h 40m
Frontier
Deal found 3/8![Frontier logo]()
$192
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:00 am
CLT
- STL
1 stop4h 42m
Delta
Wed 5/66:00 am
STL
- CLT
1 stop4h 11m
Delta
Deal found 3/8![Delta logo]()
$201
One-way flights from South Carolina to St. LouisSearch for one-way flight options from South Carolina to St. Louis. Find affordable one-way fares based on user searches. Data last updated March 11, 2026.
Search for one-way flight options from South Carolina to St. Louis. Find affordable one-way fares based on user searches. Data last updated March 11, 2026.
This Priceline deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/84:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/8![Frontier logo]()
$80
This Frontier deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/73:30 pm
CLT
- STL
1 stop8h 49m
Frontier
Deal found 3/9![Frontier logo]()
$86
This CheapOair deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:49 pm
CLT
- STL
1 stop24h 32m
Frontier
Deal found 3/9![Frontier logo]()
$92
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:49 pm
CLT
- STL
1 stop24h 23m
Frontier
Deal found 3/7![Frontier logo]()
$93
This Frontier deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/91:46 pm
CLT
- STL
1 stop10h 39m
Frontier
Deal found 3/10![Frontier logo]()
$96
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/91:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 3/9![Southwest logo]()
$99
This Frontier deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/74:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/8![Frontier logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:49 pm
CLT
- STL
1 stop24h 23m
Frontier
Deal found 3/9![Frontier logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/139:15 am
CLT
- STL
2 stops46h 35m
Frontier
Deal found 3/6![Frontier logo]()
$103
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/71:45 pm
CLT
- STL
2 stops9h 15m
Southwest
Deal found 3/8![Southwest logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/144:50 pm
SAV
- STL
2 stops15h 00m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$106
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/83:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 3/9![Southwest logo]()
$109
Find flight deals from South Carolina to St. Louis
Keep the following information in mind while searching for South Carolina to St. Louis flight deals. Data was last updated March 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $160 (Expedia) |
One-way from | $80 (Frontier) |
Popular in | March |
Cheapest in | August |
Average price | $494 |
Good round-trip deal | $344 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Tue 5/5
1:45 pm-10:00 pm
2 stops9h 15m
Lambert-St Louis
Tue 5/12
11:35 am-8:45 pm
2 stops8h 10m
$227
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 4/22
6:40 am-1:00 pm
2 stops7h 20m
Lambert-St Louis
Sat 4/25
2:25 pm-9:15 pm
1 stop5h 50m
$233
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Sat 4/25
3:50 pm-7:10 pm
1 stop4h 20m
Lambert-St Louis
Sun 4/26
11:40 am-2:30 pm
Nonstop1h 50m
$242
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 4/1
5:28 pm-11:11 pm
1 stop6h 43m
Lambert-St Louis
Wed 4/8
9:10 am-6:44 pm
2 stops8h 34m
$244
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 4/29
6:46 am-10:34 am
1 stop4h 48m
Lambert-St Louis
Wed 5/13
6:45 am-12:14 pm
1 stop4h 29m
$259
ColumbiaSt. Louis
CAE - STL
CAESTL
Columbia Metropolitan
Sat 4/18
1:59 pm-7:11 pm
1 stop6h 12m
Lambert-St Louis
Sun 4/19
6:00 am-1:14 pm
1 stop6h 14m
$260
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 4/29
9:36 am-1:05 pm
1 stop4h 29m
Lambert-St Louis
Sun 5/3
6:50 pm-11:53 pm
1 stop4h 03m
$261
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Tue 5/26
7:15 pm-10:00 pm
1 stop3h 45m
Lambert-St Louis
Fri 5/29
4:00 pm-9:30 pm
1 stop4h 30m
$264
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Sat 4/25
5:30 am-8:30 am
1 stop4h 00m
Lambert-St Louis
Sat 4/25
1:03 pm-6:11 pm
1 stop4h 08m
$267
SavannahSt. Louis
SAV - STL
SAVSTL
Savannah/Hilton Head
Wed 4/22
5:00 pm-10:10 pm
1 stop6h 10m
Lambert-St Louis
Sat 4/25
3:10 pm-6:00 pm
Nonstop1h 50m
$275
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.
CLT-STL
CHS-STL
CAE-STL
AGS-STL
GSP-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to St. Louis
USSC-STL
CLT-STL
CHS-STL
CAE-STL
AGS-STL
What is the cheapest month to book a flight from South Carolina to St. Louis?
Currently, June is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $108). Flying from South Carolina to St. Louis in January is currently the most expensive (average of $300). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to STL?
Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 11, 2026.
One of the essential ways to save on airfare from South Carolina to St. Louis is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 27% on airfare.
What is the cheapest day to fly from South Carolina to St. Louis?
Use this chart to determine the cheapest time to fly round-trip from South Carolina to St. Louis. Price data was last updated on February 21, 2026.
Travelers seeking maximum savings on their South Carolina to St. Louis flight should consider departing on Saturday mornings when fares are most often at their lowest. Tuesday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for South Carolina to St. Louis
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Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to St. Louis by cabin class
Find flights from South Carolina to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and St. Louis flights
Browse other South Carolina and St. Louis flight options. Last updated on March 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 11, 2026.
South Carolina to St. Louis flights
Consider these flights traveling from South Carolina to St. Louis.
Top 3 airlines flying from South Carolina to St. Louis
Discover the top 3 airlines that operate flights from South Carolina to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$128 | Average$350 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$229 | Average$387 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$287 | Average$371 | FlexibilityNo cancel fee | On-time63% |