$112+ Cheap flights from St. Louis (STL) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Dec 10 — Dec 171
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to South Carolina
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Cheapest flights from St. Louis to South CarolinaExplore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.
Explore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:05 pm -
1 stop5h 54m
Sat 12/56:00 am -
1 stop7h 24m
Deal found 11/5![United Airlines logo]()
$222
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:03 am -
1 stop3h 47m
Mon 12/145:34 pm -
1 stop5h 04m
Deal found 11/5![Delta logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:20 pm -
1 stop13h 18m
Mon 12/148:58 pm -
2 stops39h 19m
Deal found 11/6![Multiple Airlines logo]()
$231
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/18:02 am -
1 stop4h 58m
Tue 12/152:57 pm -
2 stops8h 18m
Deal found 11/5![United Airlines logo]()
$232
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:13 pm -
1 stop13h 25m
Mon 12/148:58 pm -
2 stops39h 19m
Deal found 11/5![Multiple Airlines logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:13 pm -
1 stop13h 25m
Sun 12/136:45 am -
2 stops29h 32m
Deal found 11/5![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:13 pm -
1 stop13h 25m
Mon 12/148:58 pm -
2 stops39h 19m
Deal found 11/5![Multiple Airlines logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/212:05 pm -
2 stops19h 33m
Tue 12/153:00 pm -
1 stop10h 12m
Deal found 11/7![Multiple Airlines logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:13 pm -
1 stop13h 25m
Sun 12/136:45 am -
2 stops29h 32m
Deal found 11/5![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:13 pm -
1 stop13h 25m
Tue 12/153:00 pm -
2 stops21h 17m
Deal found 11/5![Multiple Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:20 pm -
1 stop13h 18m
Tue 12/153:00 pm -
2 stops21h 17m
Deal found 11/6![Multiple Airlines logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/712:02 pm -
2 stops19h 36m
Sat 12/123:42 pm -
1 stop9h 30m
Deal found 11/6![Multiple Airlines logo]()
$285
Best flights from St. Louis to South CarolinaDiscover carefully curated flight deals from St. Louis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 10, 2026.
Discover carefully curated flight deals from St. Louis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 10, 2026.
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/311:30 am -
2 stops7h 10m
Tue 2/97:15 am -
2 stops8h 35m
Deal found 11/5![Southwest logo]()
$299
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/246:06 am -
1 stop7h 00m
Fri 1/299:45 am -
1 stop5h 43m
Deal found 11/5![United Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1512:36 pm -
1 stop4h 44m
Wed 12/165:40 am -
1 stop6h 49m
Deal found 11/7![Delta logo]()
$333
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:10 am -
1 stop5h 21m
Mon 12/76:47 pm -
1 stop4h 30m
Deal found 11/9![American Airlines logo]()
$345
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/410:30 am -
2 stops8h 35m
Sat 12/59:45 am -
1 stop3h 55m
Deal found 11/5![Southwest logo]()
$319
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:30 am -
2 stops8h 02m
Mon 12/75:00 pm -
1 stop6h 59m
Deal found 11/5![United Airlines logo]()
$332
This Southwest deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/167:20 am -
1 stop5h 50m
Wed 12/166:45 pm -
1 stop4h 15m
Deal found 11/7![Southwest logo]()
$333
This United Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/19:40 am -
2 stops8h 33m
Sat 12/55:34 pm -
1 stop4h 55m
Deal found 11/7![United Airlines logo]()
$338
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:03 am -
1 stop3h 47m
Wed 12/1611:24 am -
1 stop6h 19m
Deal found 11/9![Delta logo]()
$377
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:47 am -
1 stop6h 30m
Mon 12/143:37 pm -
1 stop3h 56m
Deal found 11/6![American Airlines logo]()
$403
This Delta deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:00 am -
1 stop6h 26m
Tue 1/55:53 pm -
1 stop6h 33m
Deal found 11/7![Delta logo]()
$387
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/58:45 am -
2 stops8h 25m
Mon 12/76:45 pm -
1 stop4h 15m
Deal found 11/9![Southwest logo]()
$353
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/296:45 pm -
1 stop5h 00m
Mon 2/15:33 pm -
1 stop5h 04m
Deal found 11/9![United Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/811:20 am -
2 stops6h 45m
Fri 2/127:45 pm -
1 stop5h 05m
Deal found 11/5![Southwest logo]()
$357
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:00 am -
1 stop4h 07m
Thu 11/266:00 am -
1 stop5h 01m
Deal found 11/5![Delta logo]()
$393
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:49 pm -
1 stop6h 17m
Fri 11/278:28 pm -
1 stop4h 30m
Deal found 11/7![American Airlines logo]()
$435
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/66:30 am -
2 stops6h 57m
Sun 12/135:45 pm -
1 stop6h 14m
Deal found 11/8![United Airlines logo]()
$374
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:00 am -
1 stop4h 07m
Fri 11/2711:18 am -
1 stop6h 05m
Deal found 11/5![Delta logo]()
$393
This Southwest deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/512:40 pm -
1 stop6h 15m
Fri 1/88:25 am -
1 stop5h 40m
Deal found 11/7![Southwest logo]()
$358
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/910:27 am -
1 stop4h 26m
Mon 2/2212:24 pm -
1 stop4h 03m
Deal found 11/8![American Airlines logo]()
$440
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/301:08 pm -
1 stop6h 50m
Wed 12/25:34 pm -
1 stop4h 49m
Deal found 11/5![United Airlines logo]()
$377
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/248:30 am -
2 stops7h 15m
Fri 1/2910:50 am -
2 stops8h 15m
Deal found 11/5![Southwest logo]()
$373
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:43 am -
1 stop6h 35m
Sat 12/121:13 pm -
1 stop5h 24m
Deal found 11/5![American Airlines logo]()
$455
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/41:18 pm -
2 stops9h 41m
Sat 12/56:45 am -
2 stops11h 20m
Deal found 11/5![United Airlines logo]()
$377
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/251:00 pm -
1 stop5h 08m
Wed 12/25:45 pm -
1 stop4h 38m
Deal found 11/4![United Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:43 am -
1 stop6h 35m
Mon 12/144:24 pm -
1 stop6h 46m
Deal found 11/5![American Airlines logo]()
$464
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/237:05 am -
1 stop6h 00m
Tue 12/2910:56 am -
1 stop4h 47m
Deal found 11/6![Delta logo]()
$467
This Southwest deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/110:30 am -
2 stops8h 35m
Sat 12/126:40 am -
2 stops10h 35m
Deal found 11/7![Southwest logo]()
$387
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/176:30 am -
1 stop4h 23m
Sun 2/2111:04 am -
1 stop5h 35m
Deal found 11/6![American Airlines logo]()
$468
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/98:25 am -
2 stops8h 00m
Sat 12/128:20 am -
2 stops9h 25m
Deal found 11/6![Southwest logo]()
$387
Last-minute flights from St. Louis to South CarolinaDiscover last-minute flight deals from St. Louis to South Carolina. Data last updated November 10, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to South Carolina. Data last updated November 10, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/18:02 am -
1 stop4h 58m
Tue 12/152:57 pm -
2 stops8h 18m
Deal found 11/5![United Airlines logo]()
$232
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:13 pm -
1 stop13h 25m
Mon 12/148:58 pm -
2 stops39h 19m
Deal found 11/5![Multiple Airlines logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:13 pm -
1 stop13h 25m
Sun 12/136:45 am -
2 stops29h 32m
Deal found 11/5![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:13 pm -
1 stop13h 25m
Tue 12/153:00 pm -
2 stops21h 17m
Deal found 11/5![Multiple Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:03 am -
1 stop3h 47m
Mon 12/145:34 pm -
1 stop5h 04m
Deal found 11/5![Delta logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:13 pm -
1 stop13h 25m
Mon 12/148:58 pm -
2 stops39h 19m
Deal found 11/5![Multiple Airlines logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:13 pm -
1 stop13h 25m
Sun 12/136:45 am -
2 stops29h 32m
Deal found 11/5![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/212:05 pm -
2 stops19h 33m
Tue 12/153:00 pm -
1 stop10h 12m
Deal found 11/7![Multiple Airlines logo]()
$265
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:05 pm -
1 stop5h 54m
Sat 12/56:00 am -
1 stop7h 24m
Deal found 11/5![United Airlines logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:20 pm -
1 stop13h 18m
Mon 12/148:58 pm -
2 stops39h 19m
Deal found 11/6![Multiple Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/712:02 pm -
2 stops19h 36m
Sat 12/123:42 pm -
1 stop9h 30m
Deal found 11/6![Multiple Airlines logo]()
$285
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:20 pm -
1 stop13h 18m
Tue 12/153:00 pm -
2 stops21h 17m
Deal found 11/6![Multiple Airlines logo]()
$284
One-way flights from St. Louis to South CarolinaSearch for one-way flight options from St. Louis to South Carolina. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.
Search for one-way flight options from St. Louis to South Carolina. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/712:02 pm -
2 stops26h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/7![Multiple Airlines logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:20 pm -
1 stop19h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$157
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/212:36 pm -
1 stop6h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Delta logo]()
$167
This Southwest deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/210:55 am -
2 stops6h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Southwest logo]()
$172
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/171:20 pm -
1 stop5h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Southwest logo]()
$182
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/248:00 am -
1 stop5h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![American Airlines logo]()
$190
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:00 am -
1 stop4h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Delta logo]()
$192
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/212:05 pm -
3 stops43h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Multiple Airlines logo]()
$209
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/131:20 pm -
1 stop5h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Southwest logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/184:18 pm -
2 stops15h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/66:20 pm -
3 stops41h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/6![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:35 pm -
2 stops14h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![Multiple Airlines logo]()
$238
Find flight deals from St. Louis to South Carolina
Keep the following information in mind while searching for St. Louis to South Carolina flight deals. Data was last updated November 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $222 (United Airlines) |
One-way from | $112 (Kiwi.com) |
Popular in | April |
Cheapest in | February |
Average price | $400 |
Good round-trip deal | $590 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 10, 2026.
Use the filters below to find and compare flights from St. Louis to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisGreenville
STL Lambert-St Louis - GSP Greenville
STLGSP
Lambert-St Louis
Mon 12/7
12:02 pm-3:29 pm
2 stops26h 27m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$112
St. LouisGreenville
STL Lambert-St Louis - GSP Greenville
STLGSP
Lambert-St Louis
Wed 12/16
12:02 pm-9:32 am
2 stops20h 30m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$158
St. LouisGreenville
STL Lambert-St Louis - GSP Greenville
STLGSP
Lambert-St Louis
Tue 12/15
12:36 pm-7:56 pm
1 stop6h 20m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$167
St. LouisGreenville
STL Lambert-St Louis - GSP Greenville
STLGSP
Lambert-St Louis
Wed 12/2
12:36 pm-7:56 pm
1 stop6h 20m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$167
St. LouisGreenville
STL Lambert-St Louis - GSP Greenville
STLGSP
Lambert-St Louis
Wed 12/2
10:55 am-6:10 pm
2 stops6h 15m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$172
St. LouisGreenville
STL Lambert-St Louis - GSP Greenville
STLGSP
Lambert-St Louis
Wed 12/16
10:55 am-6:10 pm
2 stops6h 15m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$172
St. LouisGreenville
STL Lambert-St Louis - GSP Greenville
STLGSP
Lambert-St Louis
Mon 12/7
5:31 pm-10:22 pm
1 stop3h 51m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$182
St. LouisGreenville
STL Lambert-St Louis - GSP Greenville
STLGSP
Lambert-St Louis
Thu 12/17
6:00 am-11:13 am
1 stop4h 13m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$182
St. LouisGreenville
STL Lambert-St Louis - GSP Greenville
STLGSP
Lambert-St Louis
Thu 12/17
2:00 pm-11:00 pm
2 stops8h 00m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$187
St. LouisHilton Head Island
STL Lambert-St Louis - HHH Hilton Head Island
STLHHH
Lambert-St Louis
Thu 12/24
8:00 am-2:30 pm
1 stop5h 30m
Hilton Head Island
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$190
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from St. Louis to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from St. Louis with our price prediction graph.
STL-GSP
STL-HHH
STL-CHS
STL-MYR
STL-CAE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to South Carolina
STL-USSC
STL-GSP
STL-HHH
STL-CHS
STL-MYR
What is the cheapest month to book a flight from St. Louis to South Carolina?
Currently, February is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $338). Flying from St. Louis to South Carolina in November is currently the most expensive (average of $469). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to SC?
Find hourly flight availability from St. Louis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 10, 2026.
When flying from St. Louis to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from St. Louis to South Carolina?
Airfare is below average for this route at the moment.
St. Louis to South Carolina flights typically cost between $323 and $597 in December.The cheapest round-trip price found within the last 5 days was $222 on United Airlines (Dec 4-Dec 5).
How far ahead should I book a flight from St. Louis to South Carolina?
The price you pay for your flight from St. Louis to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 26 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 10, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from St. Louis to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Entertainment
7.4
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Boarding
8.1
Comfort
8.0
Entertainment
7.4
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Boarding
8.1
Comfort
8.0
Entertainment
7.4
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Boarding
8.1
Comfort
8.0
Entertainment
7.4
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Boarding
8.1
Comfort
8.0
Entertainment
7.4
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Related info for your journey
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Alternative routes for St. Louis to South Carolina
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Complete your trip
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St. Louis and South Carolina flights
Browse other St. Louis and South Carolina flight options. Last updated on November 10, 2026.
Popular flight searches
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St. Louis to South Carolina flights
Consider these flights traveling from St. Louis to South Carolina.
Top 4 airlines flying from St. Louis to South Carolina
Discover the top 4 airlines that operate flights from St. Louis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$195 | Average$425 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$383 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$196 | Average$338 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$245 | Average$445 | FlexibilityNo cancel fee | On-time63% |