$105+ Cheap flights from St. Louis (STL) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/8. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Jul 15 — Jul 221
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to South Carolina with Cheapflights
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Cheapest flights from St. Louis to South CarolinaExplore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
Explore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:30 am
STL
- CLT
Nonstop1h 55m
American Airlines
Wed 11/47:23 am
CLT
- STL
Nonstop2h 04m
American Airlines
Deal found 6/11![American Airlines logo]()
$189
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:50 pm
STL
- CLT
Nonstop1h 50m
Southwest
Wed 7/81:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/12![Southwest logo]()
$197
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:05 am
STL
- CLT
1 stop7h 15m
Southwest
Wed 11/46:20 pm
CLT
- STL
Nonstop2h 10m
Southwest
Deal found 6/10![Southwest logo]()
$199
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:46 pm
STL
- CLT
1 stop5h 08m
Delta
Tue 10/64:30 pm
CLT
- STL
1 stop5h 19m
Delta
Deal found 6/10![Delta logo]()
$209
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1810:15 am
STL
- CLT
2 stops9h 55m
Southwest
Wed 8/268:05 am
CLT
- STL
1 stop4h 15m
Southwest
Deal found 6/10![Southwest logo]()
$214
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:00 am
STL
- CLT
1 stop4h 26m
Delta
Wed 7/295:30 am
CLT
- STL
1 stop3h 49m
Delta
Deal found 6/12![Delta logo]()
$217
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/153:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Wed 7/221:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Deal found 6/14![Southwest logo]()
$217
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:32 am
STL
- CHS
1 stop6h 09m
American Airlines
Wed 7/223:42 pm
CHS
- STL
1 stop7h 10m
American Airlines
Deal found 6/14![American Airlines logo]()
$237
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/203:25 pm
STL
- CHS
1 stop4h 39m
American Airlines
Tue 8/256:00 am
CHS
- STL
1 stop5h 14m
American Airlines
Deal found 6/10![American Airlines logo]()
$243
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/81:40 pm
STL
- CHS
Nonstop2h 00m
Southwest
Thu 8/135:20 pm
CHS
- STL
Nonstop2h 05m
Southwest
Deal found 6/14![Southwest logo]()
$245
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1211:00 am
STL
- SAV
1 stop3h 53m
Delta
Sat 8/2212:52 pm
SAV
- STL
1 stop4h 25m
Delta
Deal found 6/10![Delta logo]()
$246
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:30 am
STL
- CHS
2 stops7h 55m
Southwest
Tue 8/258:10 am
CHS
- STL
1 stop7h 40m
Southwest
Deal found 6/10![Southwest logo]()
$248
Best flights from St. Louis to South CarolinaDiscover carefully curated flight deals from St. Louis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
Discover carefully curated flight deals from St. Louis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:00 am
STL
- CLT
1 stop6h 31m
Delta
Sat 7/255:39 pm
CLT
- STL
1 stop6h 41m
Delta
Deal found 6/14![Delta logo]()
$217
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:40 am
STL
- CHS
1 stop8h 25m
Southwest
Mon 12/147:55 am
CHS
- STL
1 stop5h 45m
Southwest
Deal found 6/11![Southwest logo]()
$271
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/114:53 pm
STL
- GSP
1 stop5h 41m
United Airlines
Sat 7/186:10 am
GSP
- STL
1 stop7h 01m
United Airlines
Deal found 6/13![United Airlines logo]()
$297
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:38 am
STL
- HHH
1 stop4h 53m
American Airlines
Wed 11/46:40 pm
HHH
- STL
1 stop6h 25m
American Airlines
Deal found 6/11![American Airlines logo]()
$306
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/172:45 pm
STL
- CLT
Nonstop1h 50m
Southwest
Thu 8/2011:50 am
CLT
- STL
Nonstop1h 55m
Southwest
Deal found 6/14![Southwest logo]()
$274
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/134:40 pm
STL
- CHS
1 stop4h 06m
Delta
Mon 11/165:30 am
CHS
- STL
1 stop6h 18m
Delta
Deal found 6/14![Delta logo]()
$296
This deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:50 am
STL
- CLT
1 stop5h 04m
United Airlines
Sat 9/58:05 am
CLT
- STL
1 stop4h 58m
United Airlines
Deal found 6/14![United Airlines logo]()
$297
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/143:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Thu 7/163:15 pm
CHS
- STL
1 stop7h 40m
Southwest
Deal found 6/12![Southwest logo]()
$277
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:00 am
STL
- CLT
1 stop5h 54m
United Airlines
Wed 8/268:05 am
CLT
- STL
1 stop4h 57m
United Airlines
Deal found 6/14![United Airlines logo]()
$297
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:00 am
STL
- CAE
1 stop4h 14m
Delta
Sun 7/125:35 am
CAE
- STL
1 stop3h 44m
Delta
Deal found 6/14![Delta logo]()
$303
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:10 am
STL
- HHH
1 stop5h 07m
American Airlines
Thu 8/65:16 pm
HHH
- STL
1 stop6h 24m
American Airlines
Deal found 6/14![American Airlines logo]()
$344
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/83:10 pm
STL
- CLT
1 stop6h 00m
Southwest
Sat 7/1111:35 am
CLT
- STL
2 stops7h 25m
Southwest
Deal found 6/12![Southwest logo]()
$288
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1812:59 pm
STL
- CHS
1 stop7h 35m
United Airlines
Wed 8/192:54 pm
CHS
- STL
2 stops8h 06m
United Airlines
Deal found 6/11![United Airlines logo]()
$306
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:39 pm
STL
- MYR
1 stop5h 11m
Delta
Tue 7/77:59 pm
MYR
- STL
1 stop4h 54m
Delta
Deal found 6/12![Delta logo]()
$317
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:25 am
STL
- MYR
1 stop9h 10m
Southwest
Wed 7/157:15 pm
MYR
- STL
1 stop4h 50m
Southwest
Deal found 6/10![Southwest logo]()
$297
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/85:02 pm
STL
- AGS
1 stop5h 57m
American Airlines
Wed 7/155:00 am
AGS
- STL
1 stop4h 33m
American Airlines
Deal found 6/10![American Airlines logo]()
$361
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:00 am
STL
- SAV
2 stops10h 35m
United Airlines
Wed 8/194:59 pm
SAV
- STL
1 stop6h 01m
United Airlines
Deal found 6/10![United Airlines logo]()
$310
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3010:51 am
STL
- HHH
1 stop3h 41m
Delta
Sat 7/412:17 pm
HHH
- STL
1 stop6h 50m
Delta
Deal found 6/10![Delta logo]()
$323
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/293:50 pm
STL
- MYR
1 stop4h 40m
Southwest
Mon 11/27:35 pm
MYR
- STL
1 stop5h 30m
Southwest
Deal found 6/13![Southwest logo]()
$299
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/29:30 am
STL
- CAE
1 stop6h 33m
United Airlines
Sat 9/52:56 pm
CAE
- STL
2 stops8h 04m
United Airlines
Deal found 6/14![United Airlines logo]()
$323
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:00 am
STL
- CLT
1 stop5h 26m
Delta
Mon 9/79:33 am
CLT
- STL
1 stop6h 00m
Delta
Deal found 6/11![Delta logo]()
$323
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/144:45 pm
STL
- SAV
Nonstop1h 55m
Southwest
Fri 7/177:20 am
SAV
- STL
1 stop4h 30m
Southwest
Deal found 6/14![Southwest logo]()
$303
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/55:10 am
STL
- AGS
1 stop6h 09m
American Airlines
Sat 7/116:31 pm
AGS
- STL
1 stop6h 26m
American Airlines
Deal found 6/10![American Airlines logo]()
$409
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:45 pm
STL
- CLT
Nonstop1h 50m
Southwest
Sun 8/301:35 pm
CLT
- STL
Nonstop1h 55m
Southwest
Deal found 6/14![Southwest logo]()
$303
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:00 am
STL
- GSP
1 stop4h 32m
United Airlines
Wed 8/2611:25 am
GSP
- STL
2 stops11h 35m
United Airlines
Deal found 6/13![United Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/298:00 am
STL
- SAV
1 stop5h 48m
Delta
Fri 7/31:57 pm
SAV
- STL
1 stop5h 10m
Delta
Deal found 6/10![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/144:45 pm
STL
- SAV
Nonstop1h 55m
Southwest
Tue 7/214:50 pm
SAV
- STL
1 stop6h 15m
Southwest
Deal found 6/13![Southwest logo]()
$307
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/81:18 pm
STL
- CHS
2 stops9h 40m
United Airlines
Sat 8/156:30 am
CHS
- STL
1 stop6h 33m
United Airlines
Deal found 6/14![United Airlines logo]()
$340
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:30 am
STL
- HHH
2 stops8h 02m
Delta
Tue 9/112:15 pm
HHH
- STL
1 stop5h 02m
Delta
Deal found 6/12![Delta logo]()
$356
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/68:00 am
STL
- MYR
1 stop5h 45m
Southwest
Mon 8/101:55 pm
MYR
- STL
Nonstop2h 05m
Southwest
Deal found 6/12![Southwest logo]()
$308
Last-minute flights from St. Louis to South CarolinaDiscover last-minute flight deals from St. Louis to South Carolina. Data last updated June 15, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to South Carolina. Data last updated June 15, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3010:15 am
STL
- CHS
1 stop4h 55m
Southwest
Tue 7/141:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Deal found 6/14![Southwest logo]()
$277
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/14:00 pm
STL
- CLT
1 stop4h 10m
Southwest
Wed 7/151:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/10![Southwest logo]()
$227
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:50 pm
STL
- CLT
Nonstop1h 50m
Southwest
Wed 7/81:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/12![Southwest logo]()
$197
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/71:13 pm
STL
- CLT
1 stop7h 16m
United Airlines
Wed 7/88:05 am
CLT
- STL
1 stop5h 06m
United Airlines
Deal found 6/12![United Airlines logo]()
$228
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/119:30 am
STL
- CLT
1 stop11h 40m
Southwest
Wed 7/151:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/10![Southwest logo]()
$233
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/153:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Wed 7/221:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Deal found 6/14![Southwest logo]()
$217
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:32 am
STL
- CHS
1 stop6h 09m
American Airlines
Wed 7/223:42 pm
CHS
- STL
1 stop7h 10m
American Airlines
Deal found 6/14![American Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/154:45 pm
STL
- SAV
Nonstop1h 55m
Southwest
Wed 7/221:25 pm
SAV
- STL
Nonstop2h 05m
Southwest
Deal found 6/10![Southwest logo]()
$277
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:43 am
STL
- GSP
1 stop4h 43m
American Airlines
Tue 7/285:28 pm
GSP
- STL
1 stop7h 30m
American Airlines
Deal found 6/10![American Airlines logo]()
$267
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:00 am
STL
- CLT
1 stop4h 26m
Delta
Tue 7/286:59 am
CLT
- STL
1 stop6h 18m
Delta
Deal found 6/12![Delta logo]()
$217
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/255:10 am
STL
- CLT
Nonstop1h 53m
American Airlines
Tue 7/287:37 am
CLT
- STL
Nonstop1h 56m
American Airlines
Deal found 6/12![American Airlines logo]()
$246
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:08 am
STL
- SAV
1 stop6h 30m
Delta
Wed 8/56:35 am
SAV
- STL
1 stop4h 19m
Delta
Deal found 6/11![Delta logo]()
$261
One-way flights from St. Louis to South CarolinaSearch for one-way flight options from St. Louis to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
Search for one-way flight options from St. Louis to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:30 am
STL
- CLT
1 stop4h 25m
Southwest
Deal found 6/11![Southwest logo]()
$105
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:45 pm
STL
- CLT
1 stop3h 40m
Southwest
Deal found 6/12![Southwest logo]()
$109
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/99:00 am
STL
- CHS
1 stop5h 39m
Delta
Deal found 6/10![Delta logo]()
$111
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/511:00 am
STL
- SAV
1 stop3h 53m
Delta
Deal found 6/11![Delta logo]()
$113
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/119:30 am
STL
- CLT
1 stop11h 40m
Southwest
Deal found 6/14![Southwest logo]()
$114
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/810:30 am
STL
- CHS
2 stops8h 35m
Southwest
Deal found 6/11![Southwest logo]()
$117
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/72:45 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 6/10![Southwest logo]()
$118
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:00 am
STL
- CLT
1 stop5h 08m
Delta
Deal found 6/11![Delta logo]()
$119
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am
STL
- CHS
1 stop6h 25m
Delta
Deal found 6/15![Delta logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:34 pm
STL
- SAV
2 stops46h 18m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$121
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/102:45 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 6/13![Southwest logo]()
$123
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:40 am
STL
- CLT
2 stops7h 55m
Southwest
Deal found 6/11![Southwest logo]()
$124
Find flight deals from St. Louis to South Carolina
Keep the following information in mind while searching for St. Louis to South Carolina flight deals. Data was last updated June 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $189 (American Airlines) |
One-way from | $105 (Southwest) |
Popular in | April |
Cheapest in | February |
Average price | $426 |
Good round-trip deal | $336 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from St. Louis to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 7/18
6:00 am-1:31 pm
1 stop6h 31m
Charlotte Douglas
Sat 7/25
5:39 pm-11:20 pm
1 stop6h 41m
$217
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Thu 12/10
7:40 am-5:05 pm
1 stop8h 25m
Charleston
Mon 12/14
7:55 am-12:40 pm
1 stop5h 45m
$271
Quickest round-trip
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Mon 8/17
2:45 pm-5:35 pm
Nonstop1h 50m
Charlotte Douglas
Thu 8/20
11:50 am-12:45 pm
Nonstop1h 55m
$274
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 7/14
3:15 pm-6:15 pm
Nonstop2h 00m
Charleston
Thu 7/16
3:15 pm-9:55 pm
1 stop7h 40m
$277
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 7/8
3:10 pm-10:10 pm
1 stop6h 00m
Charlotte Douglas
Sat 7/11
11:35 am-6:00 pm
2 stops7h 25m
$288
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Fri 11/13
4:40 pm-9:46 pm
1 stop4h 06m
Charleston
Mon 11/16
5:30 am-10:48 am
1 stop6h 18m
$296
St. LouisGreenville
STL - GSP
STLGSP
Lambert-St Louis
Sat 7/11
4:53 pm-11:34 pm
1 stop5h 41m
Greenville
Sat 7/18
6:10 am-12:11 pm
1 stop7h 01m
$297
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 9/2
8:50 am-2:54 pm
1 stop5h 04m
Charlotte Douglas
Sat 9/5
8:05 am-12:03 pm
1 stop4h 58m
$297
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Tue 8/25
8:00 am-2:54 pm
1 stop5h 54m
Charlotte Douglas
Wed 8/26
8:05 am-12:02 pm
1 stop4h 57m
$297
St. LouisMyrtle Beach
STL - MYR
STLMYR
Lambert-St Louis
Wed 7/8
8:25 am-6:35 pm
1 stop9h 10m
Myrtle Beach Intl
Wed 7/15
7:15 pm-11:05 pm
1 stop4h 50m
$297
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from St. Louis to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from St. Louis with our price prediction graph.
STL-CLT
STL-CAE
STL-GSP
STL-CHS
STL-SAV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to South Carolina
STL-USSC
STL-CLT
STL-CAE
STL-GSP
STL-CHS
What is the cheapest month to book a flight from St. Louis to South Carolina?
Currently, July is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $89). Flying from St. Louis to South Carolina in January is currently the most expensive (average of $275). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to SC?
Find hourly flight availability from St. Louis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 15, 2026.
When flying from St. Louis to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from St. Louis to South Carolina?
How far ahead should I book a flight from St. Louis to South Carolina?
The price you pay for your flight from St. Louis to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 83 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated June 15, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from St. Louis to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
7.9
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from St. Louis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for St. Louis to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to South Carolina by cabin class
Find flights from St. Louis to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and South Carolina flights
Browse other St. Louis and South Carolina flight options. Last updated on June 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
St. Louis to South Carolina flights
Consider these flights traveling from St. Louis to South Carolina.
Top 4 airlines flying from St. Louis to South Carolina
Discover the top 4 airlines that operate flights from St. Louis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$146 | Average$355 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$193 | Average$400 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$338 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$245 | Average$441 | FlexibilityNo cancel fee | On-time63% |