$64+ Cheap flights from St. Louis (STL) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/6. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Jan 3 — Jan 101
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to South Carolina
Cheapest flights from St. Louis to South CarolinaExplore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.
Explore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.
This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 pmSTL - CHS
1 stop5h 45mAmerican Airlines
Wed 1/145:57 pmCHS - STL
1 stop5h 58mAmerican Airlines
Deal found 12/3![American Airlines logo]()
$159
This Mytrip deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/177:43 pmSTL - CLT
1 stop14h 39mFrontier
Sun 12/219:33 pmCLT - STL
1 stop13h 12mFrontier
Deal found 12/2![Frontier logo]()
$172
This Booking.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/107:43 pmSTL - CLT
1 stop20h 06mFrontier
Wed 12/1710:45 amCLT - STL
1 stop12h 48mFrontier
Deal found 12/3![Frontier logo]()
$174
This Kiwi.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/159:54 amSTL - CLT
1 stop9h 31mFrontier
Tue 12/1610:45 amCLT - STL
1 stop12h 48mFrontier
Deal found 12/3![Frontier logo]()
$180
This Mytrip deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/93:30 pmSTL - CLT
1 stop17h 20mFrontier
Thu 12/1110:33 pmCLT - STL
1 stop11h 26mFrontier
Deal found 12/2![Frontier logo]()
$192
This Mytrip deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/163:30 pmSTL - CLT
1 stop17h 20mFrontier
Fri 12/192:51 pmCLT - STL
1 stop5h 51mFrontier
Deal found 12/2![Frontier logo]()
$197
This Priceline deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/143:30 pmSTL - CLT
1 stop5h 08mFrontier
Fri 12/192:51 pmCLT - STL
1 stop5h 51mFrontier
Deal found 12/3![Frontier logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/103:30 pmSTL - CLT
1 stop27h 30mMultiple Airlines
Wed 12/1710:45 amCLT - STL
2 stops23h 55mMultiple Airlines
Deal found 12/3![Multiple Airlines logo]()
$213
This Southwest deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:20 pmSTL - CLT
1 stop4h 40mSouthwest
Tue 1/68:25 amCLT - STL
Nonstop2h 10mSouthwest
Deal found 12/2![Southwest logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/163:30 pmSTL - CAE
2 stops39h 18mMultiple Airlines
Sun 1/1112:20 pmCAE - STL
1 stop20h 45mMultiple Airlines
Deal found 12/3![Multiple Airlines logo]()
$217
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:04 pmSTL - CLT
Nonstop1h 56mAmerican Airlines
Thu 12/259:00 amCLT - STL
Nonstop1h 59mAmerican Airlines
Deal found 12/2![American Airlines logo]()
$217
This Booking.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/137:43 pmSTL - CLT
1 stop20h 06mFrontier
Fri 12/192:51 pmCLT - STL
1 stop8h 42mFrontier
Deal found 12/3![Frontier logo]()
$220
Find flight deals from St. Louis to South Carolina
Keep the following information in mind while searching for St. Louis to South Carolina flight deals. Data was last updated December 4, 2025.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $123 (American Airlines) |
One-way from | $64 (Frontier) |
Popular in | December |
Cheapest in | July |
Average price | $460 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from St. Louis to South Carolina that are best for you.
Fly from
St. Louis
Fly to
South Carolina
Route
Depart
Return
Price
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 1/24
8:13 am-11:11 am
Nonstop1h 58m
Charlotte Douglas
Sat 1/31
10:23 pm-11:26 pm
Nonstop2h 03m
$123
St. LouisSavannah
STL - SAV
STLSAV
Lambert-St Louis
Tue 2/24
6:00 am-11:37 am
1 stop4h 37m
Savannah/Hilton Head
Tue 3/3
6:25 am-12:31 pm
2 stops7h 06m
$164
St. LouisSavannah
STL - SAV
STLSAV
Lambert-St Louis
Wed 1/7
3:54 pm-11:16 pm
1 stop6h 22m
Savannah/Hilton Head
Tue 1/13
3:05 pm-9:51 pm
2 stops7h 46m
$164
St. LouisSavannah
STL - SAV
STLSAV
Lambert-St Louis
Tue 1/13
6:52 am-12:07 pm
1 stop4h 15m
Savannah/Hilton Head
Wed 1/21
3:05 pm-9:51 pm
2 stops7h 46m
$164
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 1/24
10:19 am-4:05 pm
1 stop4h 46m
Charlotte Douglas
Sat 1/31
5:00 pm-8:43 pm
1 stop4h 43m
$177
St. LouisSavannah
STL - SAV
STLSAV
Lambert-St Louis
Sat 2/21
5:00 pm-9:31 pm
1 stop3h 31m
Savannah/Hilton Head
Sat 2/28
5:30 am-9:06 am
1 stop4h 36m
$181
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Mon 2/2
2:30 pm-5:15 pm
Nonstop1h 45m
Charlotte Douglas
Thu 2/5
5:05 pm-6:15 pm
Nonstop2h 10m
$194
St. LouisSavannah
STL - SAV
STLSAV
Lambert-St Louis
Tue 1/13
6:05 am-3:20 pm
2 stops8h 15m
Savannah/Hilton Head
Wed 1/21
11:15 am-7:00 pm
2 stops8h 45m
$196
St. LouisSavannah
STL - SAV
STLSAV
Lambert-St Louis
Fri 2/27
6:47 pm-11:57 pm
1 stop4h 10m
Savannah/Hilton Head
Tue 3/3
11:37 am-4:42 pm
1 stop6h 05m
$197
St. LouisColumbia
STL - CAE
STLCAE
Lambert-St Louis
Wed 1/21
6:00 am-11:58 am
1 stop4h 58m
Columbia Metropolitan
Sat 1/24
12:45 pm-3:56 pm
1 stop4h 11m
$199
Showing 1-10 of 60 results
Best time to book a flight from St. Louis to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to South Carolina
What is the cheapest month to book a flight from St. Louis to South Carolina?
Currently, February is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $84). Flying from St. Louis to South Carolina in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to SC?
Find hourly flight availability from St. Louis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 4, 2025.
Unlike in the morning, when flights are generally more expensive, you can save up to 26% on flights from St. Louis to South Carolina by exploring options for tickets in the afternoon.
What is the cheapest day to fly from St. Louis to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from St. Louis to South Carolina. Price data was last updated on December 16, 2024.
Travelers seeking maximum savings on their St. Louis to South Carolina flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Tuesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 4, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and American Airlines from St. Louis to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Overall
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Overall
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Overall
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Overall
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Overall
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from St. Louis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for St. Louis to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from St. Louis to South Carolina
Discover the top 4 airlines that operate flights from St. Louis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$84 | Average$209 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$150 | Average$368 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$226 | Average$384 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$274 | Average$400 | FlexibilityNo cancel fee | On-time63% |