$90+ Cheap flights from St. Louis (STL) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/11. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Sep 9 — Sep 161
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from St. Louis to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to South Carolina
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to South CarolinaExplore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 10, 2026.
Explore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 10, 2026.
This Trip.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:02 pm -
1 stop19h 48m
Mon 8/318:56 am -
1 stop7h 32m
Deal found 8/6![Frontier logo]()
$191
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:23 am -
Nonstop1h 54m
Sun 9/64:35 pm -
Nonstop1h 59m
Deal found 8/8![American Airlines logo]()
$198
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:21 am -
Nonstop1h 54m
Mon 9/149:50 pm -
Nonstop1h 52m
Deal found 8/10![American Airlines logo]()
$199
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/13:25 pm -
Nonstop1h 57m
Tue 9/1512:10 pm -
Nonstop1h 53m
Deal found 8/10![American Airlines logo]()
$207
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/51:40 pm -
Nonstop2h 00m
Sat 9/126:45 am -
Nonstop2h 00m
Deal found 8/9![Southwest logo]()
$208
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/282:45 pm -
Nonstop1h 50m
Mon 10/59:00 pm -
1 stop3h 35m
Deal found 8/10![Southwest logo]()
$210
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:22 am -
Nonstop1h 53m
Tue 9/88:35 am -
Nonstop1h 57m
Deal found 8/10![American Airlines logo]()
$215
This Delta deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/51:04 pm -
1 stop6h 23m
Sun 9/66:00 am -
1 stop4h 20m
Deal found 8/8![Delta logo]()
$217
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:40 pm -
1 stop4h 35m
Sat 9/56:45 am -
Nonstop2h 00m
Deal found 8/9![Southwest logo]()
$218
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1712:00 pm -
1 stop5h 12m
Mon 9/217:39 pm -
1 stop5h 03m
Deal found 8/10![Delta logo]()
$219
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/223:45 pm -
1 stop4h 30m
Tue 9/296:50 am -
2 stops9h 00m
Deal found 8/10![Southwest logo]()
$221
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/39:25 am -
2 stops8h 15m
Mon 10/59:00 pm -
1 stop3h 35m
Deal found 8/10![Southwest logo]()
$222
Best flights from St. Louis to South CarolinaDiscover carefully curated flight deals from St. Louis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 10, 2026.
Discover carefully curated flight deals from St. Louis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 10, 2026.
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/282:45 pm -
Nonstop1h 50m
Mon 10/59:00 pm -
1 stop3h 35m
Deal found 8/10![Southwest logo]()
$210
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:05 am -
1 stop5h 25m
Mon 9/147:39 pm -
1 stop5h 03m
Deal found 8/10![Delta logo]()
$219
This United Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:00 am -
1 stop6h 13m
Thu 9/105:45 am -
2 stops7h 12m
Deal found 8/8![United Airlines logo]()
$277
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:00 am -
1 stop7h 25m
Wed 11/412:25 pm -
1 stop6h 04m
Deal found 8/9![American Airlines logo]()
$301
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/223:45 pm -
1 stop4h 30m
Tue 9/296:30 pm -
1 stop4h 15m
Deal found 8/10![Southwest logo]()
$215
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am -
1 stop4h 54m
Sun 9/67:13 am -
1 stop5h 43m
Deal found 8/7![Delta logo]()
$251
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2611:15 am -
1 stop7h 25m
Sat 10/38:00 am -
2 stops9h 15m
Deal found 8/10![Southwest logo]()
$236
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1112:40 pm -
Nonstop1h 55m
Mon 9/145:35 pm -
1 stop5h 10m
Deal found 8/10![Southwest logo]()
$237
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:00 am -
1 stop5h 26m
Mon 9/76:00 am -
1 stop6h 46m
Deal found 8/7![Delta logo]()
$275
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:40 am -
1 stop4h 41m
Tue 9/85:38 pm -
1 stop5h 22m
Deal found 8/7![United Airlines logo]()
$312
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/65:23 am -
1 stop4h 46m
Sun 9/136:29 pm -
1 stop6h 12m
Deal found 8/9![American Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/113:35 pm -
Nonstop2h 00m
Mon 9/146:35 am -
1 stop4h 35m
Deal found 8/5![Southwest logo]()
$241
This Delta deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:00 am -
1 stop6h 20m
Sun 9/66:00 am -
1 stop4h 20m
Deal found 8/8![Delta logo]()
$288
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2812:59 pm -
1 stop7h 29m
Sun 8/306:25 am -
1 stop4h 47m
Deal found 8/6![United Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:35 am -
1 stop5h 37m
Sun 9/135:09 am -
1 stop4h 21m
Deal found 8/7![American Airlines logo]()
$333
This Southwest deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/51:40 pm -
Nonstop2h 00m
Thu 9/105:20 pm -
Nonstop2h 05m
Deal found 8/8![Southwest logo]()
$252
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:30 am -
1 stop5h 46m
Wed 10/289:50 am -
2 stops8h 01m
Deal found 8/6![United Airlines logo]()
$330
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/810:40 am -
1 stop3h 47m
Sat 9/1212:17 pm -
1 stop3h 32m
Deal found 8/10![Delta logo]()
$310
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/310:05 am -
2 stops8h 25m
Mon 10/58:40 pm -
1 stop3h 55m
Deal found 8/10![Southwest logo]()
$262
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:00 pm -
1 stop5h 28m
Mon 9/145:10 am -
1 stop5h 19m
Deal found 8/9![American Airlines logo]()
$361
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/293:32 pm -
1 stop4h 56m
Tue 9/110:23 am -
1 stop6h 15m
Deal found 8/10![United Airlines logo]()
$334
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:45 am -
2 stops8h 10m
Wed 8/265:30 pm -
1 stop5h 40m
Deal found 8/7![Southwest logo]()
$264
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:13 pm -
1 stop4h 46m
Sun 10/46:00 am -
1 stop5h 18m
Deal found 8/9![American Airlines logo]()
$367
This Delta deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:00 am -
1 stop6h 11m
Mon 9/76:35 am -
1 stop3h 45m
Deal found 8/8![Delta logo]()
$334
This United Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2712:59 pm -
1 stop7h 20m
Fri 8/286:45 am -
1 stop5h 32m
Deal found 8/8![United Airlines logo]()
$346
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:05 am -
2 stops9h 25m
Wed 10/288:10 am -
1 stop4h 25m
Deal found 8/6![Southwest logo]()
$266
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/23:39 pm -
1 stop6h 51m
Sat 9/56:00 am -
1 stop18h 31m
Deal found 8/6![Delta logo]()
$335
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:15 pm -
1 stop5h 26m
Tue 11/37:00 am -
2 stops9h 43m
Deal found 8/6![United Airlines logo]()
$350
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:22 am -
1 stop5h 52m
Mon 9/76:00 am -
1 stop5h 14m
Deal found 8/7![American Airlines logo]()
$391
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2510:45 am -
2 stops7h 40m
Sat 8/298:40 am -
2 stops5h 55m
Deal found 8/10![Southwest logo]()
$269
Last-minute flights from St. Louis to South CarolinaDiscover last-minute flight deals from St. Louis to South Carolina. Data last updated August 10, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to South Carolina. Data last updated August 10, 2026 and is based on user searches.
This Trip.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:02 pm -
1 stop19h 48m
Mon 8/318:56 am -
1 stop7h 32m
Deal found 8/6![Frontier logo]()
$191
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/13:25 pm -
Nonstop1h 57m
Tue 9/1512:10 pm -
Nonstop1h 53m
Deal found 8/10![American Airlines logo]()
$207
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:40 pm -
1 stop4h 35m
Sat 9/56:45 am -
Nonstop2h 00m
Deal found 8/9![Southwest logo]()
$218
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:34 am -
Nonstop1h 55m
Sun 9/66:44 pm -
Nonstop1h 58m
Deal found 8/10![American Airlines logo]()
$206
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:22 am -
Nonstop1h 53m
Tue 9/88:35 am -
Nonstop1h 57m
Deal found 8/10![American Airlines logo]()
$215
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:23 am -
Nonstop1h 54m
Sun 9/64:35 pm -
Nonstop1h 59m
Deal found 8/8![American Airlines logo]()
$198
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/51:40 pm -
Nonstop2h 00m
Sat 9/126:45 am -
Nonstop2h 00m
Deal found 8/9![Southwest logo]()
$208
This Delta deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/51:04 pm -
1 stop6h 23m
Sun 9/66:00 am -
1 stop4h 20m
Deal found 8/8![Delta logo]()
$217
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:21 am -
Nonstop1h 54m
Mon 9/149:50 pm -
Nonstop1h 52m
Deal found 8/10![American Airlines logo]()
$199
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/113:45 pm -
1 stop5h 10m
Fri 9/1811:50 am -
Nonstop1h 55m
Deal found 8/10![Southwest logo]()
$220
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1712:00 pm -
1 stop5h 12m
Mon 9/217:39 pm -
1 stop5h 03m
Deal found 8/10![Delta logo]()
$219
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/282:45 pm -
Nonstop1h 50m
Mon 10/59:00 pm -
1 stop3h 35m
Deal found 8/10![Southwest logo]()
$210
One-way flights from St. Louis to South CarolinaSearch for one-way flight options from St. Louis to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 10, 2026.
Search for one-way flight options from St. Louis to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 10, 2026.
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/113:35 pm -
Nonstop2h 00m
Deal found 8/10![Southwest logo]()
$90
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:17 pm -
2 stops21h 41m
Deal found 8/7![Frontier logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:17 pm -
2 stops37h 21m
Deal found 8/7![Multiple Airlines logo]()
$96
This Trip.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:02 pm -
1 stop19h 48m
Deal found 8/6![Frontier logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:17 pm -
2 stops24h 18m
Deal found 8/9![Frontier logo]()
$99
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:35 am -
Nonstop1h 55m
Deal found 8/6![American Airlines logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2610:35 am -
2 stops45h 03m
Deal found 8/10![Multiple Airlines logo]()
$99
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/94:40 pm -
Nonstop1h 45m
Deal found 8/10![Southwest logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:29 pm -
2 stops41h 09m
Deal found 8/6![Multiple Airlines logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:17 pm -
2 stops36h 44m
Deal found 8/7![Frontier logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:29 pm -
2 stops41h 23m
Deal found 8/10![Frontier logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/610:35 am -
2 stops44h 05m
Deal found 8/6![Frontier logo]()
$107
Find flight deals from St. Louis to South Carolina
Keep the following information in mind while searching for St. Louis to South Carolina flight deals. Data was last updated August 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $191 (Trip.com) |
One-way from | $90 (Southwest) |
Popular in | April |
Cheapest in | February |
Average price | $397 |
Good one-way deal | $444 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from St. Louis to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisCharlotte
STL Lambert-St Louis - CLT Charlotte Douglas
STLCLT
Lambert-St Louis
Mon 9/28
2:45 pm-5:35 pm
Nonstop1h 50m
Charlotte Douglas
Mon 10/5
9:00 pm-11:35 pm
1 stop3h 35m
$210
St. LouisCharlotte
STL Lambert-St Louis - CLT Charlotte Douglas
STLCLT
Lambert-St Louis
Tue 9/22
3:45 pm-9:15 pm
1 stop4h 30m
Charlotte Douglas
Tue 9/29
6:30 pm-9:45 pm
1 stop4h 15m
$215
St. LouisCharlotte
STL Lambert-St Louis - CLT Charlotte Douglas
STLCLT
Lambert-St Louis
Thu 9/10
7:05 am-1:30 pm
1 stop5h 25m
Charlotte Douglas
Mon 9/14
7:39 pm-11:42 pm
1 stop5h 03m
$219
St. LouisSavannah
STL Lambert-St Louis - SAV Savannah/Hilton Head
STLSAV
Lambert-St Louis
Sat 9/26
11:15 am-7:40 pm
1 stop7h 25m
Savannah/Hilton Head
Sat 10/3
8:00 am-4:15 pm
2 stops9h 15m
$236
St. LouisSavannah
STL Lambert-St Louis - SAV Savannah/Hilton Head
STLSAV
Lambert-St Louis
Fri 9/11
12:40 pm-3:35 pm
Nonstop1h 55m
Savannah/Hilton Head
Mon 9/14
5:35 pm-9:45 pm
1 stop5h 10m
$237
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Fri 9/11
3:35 pm-6:35 pm
Nonstop2h 00m
Charleston
Mon 9/14
6:35 am-10:10 am
1 stop4h 35m
$241
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Wed 9/2
6:00 am-11:54 am
1 stop4h 54m
Charleston
Sun 9/6
7:13 am-11:56 am
1 stop5h 43m
$251
Quickest round-trip
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Sat 9/5
1:40 pm-4:40 pm
Nonstop2h 00m
Charleston
Thu 9/10
5:20 pm-6:25 pm
Nonstop2h 05m
$252
St. LouisGreenville
STL Lambert-St Louis - GSP Greenville
STLGSP
Lambert-St Louis
Sat 10/3
10:05 am-7:30 pm
2 stops8h 25m
Greenville
Mon 10/5
8:40 pm-11:35 pm
1 stop3h 55m
$262
St. LouisGreenville
STL Lambert-St Louis - GSP Greenville
STLGSP
Lambert-St Louis
Sat 8/22
5:45 am-2:55 pm
2 stops8h 10m
Greenville
Wed 8/26
5:30 pm-10:10 pm
1 stop5h 40m
$264
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from St. Louis to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from St. Louis with our price prediction graph.
STL-CLT
STL-CHS
STL-HHH
STL-SAV
STL-CAE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to South Carolina
STL-USSC
STL-CLT
STL-CHS
STL-HHH
STL-SAV
What is the cheapest month to book a flight from St. Louis to South Carolina?
Currently, October is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $348). Flying from St. Louis to South Carolina in July is currently the most expensive (average of $427). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to SC?
Find hourly flight availability from St. Louis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 10, 2026.
When flying from St. Louis to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from St. Louis to South Carolina?
Airfare is below average for this route at the moment.
St. Louis to South Carolina flights typically cost between $256 and $543 in September.The cheapest round-trip price found within the last 5 days was $208 on Southwest (Sep 5-Sep 12).
How far ahead should I book a flight from St. Louis to South Carolina?
The price you pay for your flight from St. Louis to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 50 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 10, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from St. Louis to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from St. Louis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for St. Louis to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to South Carolina by cabin class
Find flights from St. Louis to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and South Carolina flights
Browse other St. Louis and South Carolina flight options. Last updated on August 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
St. Louis to South Carolina flights
Consider these flights traveling from St. Louis to South Carolina.
Top 4 airlines flying from St. Louis to South Carolina
Discover the top 4 airlines that operate flights from St. Louis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$163 | Average$358 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$195 | Average$428 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$338 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$256 | Average$458 | FlexibilityNo cancel fee | On-time63% |