$84+ Cheap flights from St. Louis (STL) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/13. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Oct 23 — Oct 301
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from St. Louis to South CarolinaExplore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
Explore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:32 am -
1 stop7h 13m
Tue 11/37:00 am -
1 stop8h 04m
Deal found 9/22![American Airlines logo]()
$167
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/261:20 pm -
1 stop7h 49m
Wed 10/287:17 am -
1 stop6h 43m
Deal found 9/22![American Airlines logo]()
$187
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:29 am -
1 stop6h 33m
Wed 10/284:12 pm -
1 stop5h 20m
Deal found 9/22![American Airlines logo]()
$206
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:28 am -
1 stop6h 34m
Wed 10/217:00 am -
1 stop6h 03m
Deal found 9/21![American Airlines logo]()
$207
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/264:30 pm -
Nonstop1h 55m
Wed 10/288:10 am -
1 stop4h 25m
Deal found 9/22![Southwest logo]()
$218
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/271:00 pm -
1 stop5h 11m
Mon 11/23:29 pm -
1 stop7h 11m
Deal found 9/22![United Airlines logo]()
$222
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:30 pm -
Nonstop1h 55m
Wed 10/217:15 am -
1 stop4h 35m
Deal found 9/18![Southwest logo]()
$227
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:30 am -
1 stop7h 05m
Tue 11/31:30 pm -
2 stops6h 55m
Deal found 9/22![Southwest logo]()
$232
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/142:31 pm -
1 stop3h 47m
Tue 11/172:00 pm -
1 stop5h 13m
Deal found 9/21![Delta logo]()
$237
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:50 pm -
2 stops13h 20m
Sat 10/246:15 am -
1 stop4h 00m
Deal found 9/21![Southwest logo]()
$238
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/193:11 pm -
1 stop5h 22m
Wed 10/216:00 am -
2 stops7h 13m
Deal found 9/18![United Airlines logo]()
$242
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2710:48 am -
1 stop4h 35m
Sat 10/316:43 pm -
1 stop6h 36m
Deal found 9/18![American Airlines logo]()
$259
Best flights from St. Louis to South CarolinaDiscover carefully curated flight deals from St. Louis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
Discover carefully curated flight deals from St. Louis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:10 am -
1 stop4h 05m
Tue 11/36:25 pm -
1 stop4h 30m
Deal found 9/19![Southwest logo]()
$227
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:00 am -
1 stop5h 04m
Wed 10/282:52 pm -
2 stops7h 48m
Deal found 9/22![United Airlines logo]()
$261
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/44:00 pm -
1 stop3h 21m
Fri 11/65:40 am -
1 stop4h 37m
Deal found 9/18![Delta logo]()
$305
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:28 am -
1 stop4h 37m
Wed 11/412:25 pm -
1 stop6h 04m
Deal found 9/19![American Airlines logo]()
$321
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/712:40 pm -
1 stop6h 20m
Wed 12/96:35 am -
2 stops7h 30m
Deal found 9/21![Southwest logo]()
$232
This Southwest deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/611:30 am -
2 stops7h 20m
Tue 1/126:45 am -
2 stops9h 20m
Deal found 9/20![Southwest logo]()
$237
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:50 pm -
2 stops13h 20m
Wed 10/281:55 pm -
2 stops7h 05m
Deal found 9/22![Southwest logo]()
$243
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/219:04 am -
1 stop6h 53m
Wed 10/2812:21 pm -
2 stops10h 19m
Deal found 9/21![United Airlines logo]()
$330
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:00 am -
1 stop5h 31m
Tue 12/16:59 pm -
1 stop6h 06m
Deal found 9/18![Delta logo]()
$347
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:30 am -
2 stops7h 40m
Tue 11/107:05 am -
2 stops7h 00m
Deal found 9/19![Southwest logo]()
$269
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/191:29 pm -
2 stops9h 46m
Wed 10/216:00 am -
2 stops10h 43m
Deal found 9/19![United Airlines logo]()
$337
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:47 am -
1 stop3h 43m
Wed 11/412:23 pm -
2 stops9h 28m
Deal found 9/22![Delta logo]()
$350
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/211:45 pm -
1 stop7h 15m
Wed 10/286:40 am -
2 stops7h 25m
Deal found 9/22![Southwest logo]()
$271
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:00 am -
1 stop5h 21m
Wed 11/43:35 pm -
1 stop7h 17m
Deal found 9/21![United Airlines logo]()
$346
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:54 am -
2 stops8h 51m
Wed 10/76:08 pm -
1 stop6h 51m
Deal found 9/17![American Airlines logo]()
$432
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:05 am -
1 stop4h 35m
Sat 11/285:35 am -
1 stop4h 28m
Deal found 9/22![Delta logo]()
$377
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:30 am -
2 stops10h 55m
Mon 11/27:40 am -
2 stops12h 30m
Deal found 9/22![Southwest logo]()
$288
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/281:08 pm -
1 stop6h 50m
Thu 10/295:50 am -
1 stop5h 58m
Deal found 9/22![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:31 pm -
1 stop5h 52m
Sat 11/285:11 pm -
1 stop6h 03m
Deal found 9/19![American Airlines logo]()
$459
This Southwest deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/171:25 pm -
2 stops8h 30m
Thu 1/73:15 pm -
2 stops7h 30m
Deal found 9/20![Southwest logo]()
$297
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/271:08 pm -
2 stops8h 52m
Sat 10/3110:42 am -
1 stop4h 47m
Deal found 9/21![United Airlines logo]()
$364
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2810:45 am -
2 stops7h 00m
Sat 10/310:18 am -
2 stops7h 30m
Deal found 9/22![American Airlines logo]()
$467
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:35 pm -
1 stop4h 22m
Wed 10/212:16 pm -
1 stop4h 59m
Deal found 9/18![Delta logo]()
$438
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1511:35 am -
1 stop4h 22m
Sat 10/1710:23 am -
2 stops10h 18m
Deal found 9/18![United Airlines logo]()
$386
This Southwest deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/125:50 pm -
1 stop4h 00m
Fri 10/168:40 pm -
1 stop4h 00m
Deal found 9/20![Southwest logo]()
$324
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:47 am -
1 stop4h 30m
Sat 11/285:53 am -
1 stop5h 51m
Deal found 9/19![American Airlines logo]()
$491
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:00 am -
2 stops7h 26m
Wed 10/73:03 pm -
2 stops7h 18m
Deal found 9/22![United Airlines logo]()
$388
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:30 pm -
Nonstop1h 55m
Mon 10/195:35 am -
1 stop6h 25m
Deal found 9/19![Southwest logo]()
$340
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/179:30 am -
1 stop7h 42m
Sat 10/2412:30 pm -
2 stops12h 01m
Deal found 9/19![United Airlines logo]()
$391
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:10 am -
1 stop4h 20m
Tue 10/271:35 pm -
1 stop6h 45m
Deal found 9/19![Southwest logo]()
$347
Last-minute flights from St. Louis to South CarolinaDiscover last-minute flight deals from St. Louis to South Carolina. Data last updated September 23, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to South Carolina. Data last updated September 23, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:28 am -
1 stop6h 34m
Sat 10/316:40 am -
1 stop6h 29m
Deal found 9/20![American Airlines logo]()
$237
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:28 am -
1 stop6h 34m
Wed 10/217:00 am -
1 stop6h 03m
Deal found 9/21![American Airlines logo]()
$207
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:30 pm -
Nonstop1h 55m
Wed 10/217:15 am -
1 stop4h 35m
Deal found 9/18![Southwest logo]()
$227
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:50 pm -
2 stops13h 20m
Sat 10/246:15 am -
1 stop4h 00m
Deal found 9/21![Southwest logo]()
$238
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/193:11 pm -
1 stop5h 22m
Wed 10/216:00 am -
2 stops7h 13m
Deal found 9/18![United Airlines logo]()
$242
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:29 am -
1 stop6h 33m
Wed 10/284:12 pm -
1 stop5h 20m
Deal found 9/22![American Airlines logo]()
$206
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/261:20 pm -
1 stop7h 49m
Wed 10/287:17 am -
1 stop6h 43m
Deal found 9/22![American Airlines logo]()
$187
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/264:30 pm -
Nonstop1h 55m
Wed 10/288:10 am -
1 stop4h 25m
Deal found 9/22![Southwest logo]()
$218
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:32 am -
1 stop7h 13m
Tue 11/37:00 am -
1 stop8h 04m
Deal found 9/22![American Airlines logo]()
$167
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/271:00 pm -
1 stop5h 11m
Mon 11/23:29 pm -
1 stop7h 11m
Deal found 9/22![United Airlines logo]()
$222
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:30 am -
1 stop7h 05m
Tue 11/31:30 pm -
2 stops6h 55m
Deal found 9/22![Southwest logo]()
$232
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2710:48 am -
1 stop4h 35m
Sat 10/316:43 pm -
1 stop6h 36m
Deal found 9/18![American Airlines logo]()
$259
One-way flights from St. Louis to South CarolinaSearch for one-way flight options from St. Louis to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 23, 2026.
Search for one-way flight options from St. Louis to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 23, 2026.
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:29 am -
1 stop6h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$84
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:29 am -
1 stop6h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$94
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:35 pm -
2 stops37h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$103
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:30 pm -
Nonstop1h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Southwest logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1612:02 pm -
2 stops33h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$115
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/215:13 pm -
1 stop5h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Delta logo]()
$119
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:29 am -
1 stop6h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:35 pm -
3 stops36h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:35 pm -
2 stops40h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:44 pm -
2 stops40h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$127
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:50 pm -
1 stop4h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Southwest logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:35 pm -
2 stops40h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Multiple Airlines logo]()
$132
Find flight deals from St. Louis to South Carolina
Keep the following information in mind while searching for St. Louis to South Carolina flight deals. Data was last updated September 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $187 (American Airlines) |
One-way from | $84 (American Airlines) |
Popular in | July |
Cheapest in | October |
Average price | $430 |
Good round-trip deal | $236 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 23, 2026.
Use the filters below to find and compare flights from St. Louis to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Mon 10/19
4:30 pm-7:25 pm
Nonstop1h 55m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$109
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Mon 10/26
4:30 pm-7:25 pm
Nonstop1h 55m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$109
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Tue 10/20
1:29 pm-9:33 pm
1 stop7h 04m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$114
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Mon 10/19
1:29 pm-9:33 pm
1 stop7h 04m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$114
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Thu 12/24
4:49 pm-10:43 pm
1 stop4h 54m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$119
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Tue 12/15
10:06 am-4:27 pm
1 stop5h 21m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$119
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Sat 10/17
9:04 am-6:48 pm
2 stops8h 44m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$119
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Tue 11/17
2:31 pm-9:10 pm
1 stop5h 39m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$119
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Tue 10/20
6:00 am-11:35 am
1 stop4h 35m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$119
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Mon 12/21
5:13 pm-11:54 pm
1 stop5h 41m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$119
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from St. Louis to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from St. Louis with our price prediction graph.
STL-CHS
STL-GSP
STL-HHH
STL-CAE
STL-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to South Carolina
STL-USSC
STL-CHS
STL-GSP
STL-HHH
STL-CAE
What is the cheapest month to book a flight from St. Louis to South Carolina?
Currently, October is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $340). Flying from St. Louis to South Carolina in November is currently the most expensive (average of $436). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to SC?
Find hourly flight availability from St. Louis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 23, 2026.
When flying from St. Louis to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from St. Louis to South Carolina?
Airfare is below average for this route at the moment.
St. Louis to South Carolina flights typically cost between $303 and $484 in October.The cheapest round-trip price found within the last 5 days was $187 on American Airlines (Oct 26-Oct 28).
How far ahead should I book a flight from St. Louis to South Carolina?
The price you pay for your flight from St. Louis to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 41 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 23, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from St. Louis to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Related info for your journey
Find useful and relevant information for your journey from St. Louis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for St. Louis to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to South Carolina by cabin class
Find flights from St. Louis to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and South Carolina flights
Browse other St. Louis and South Carolina flight options. Last updated on September 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
St. Louis to South Carolina flights
Consider these flights traveling from St. Louis to South Carolina.
Top 4 airlines flying from St. Louis to South Carolina
Discover the top 4 airlines that operate flights from St. Louis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$195 | Average$431 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$376 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$196 | Average$358 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$239 | Average$431 | FlexibilityNo cancel fee | On-time63% |