$70+ Cheap flights from St. Louis (STL) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/26. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
May 30 — Jun 61
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from St. Louis to South CarolinaExplore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.
Explore the most affordable flight options available from St. Louis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/310:49 am
STL
- CHS
1 stop4h 00m
Delta
Wed 6/105:10 am
CHS
- STL
1 stop5h 36m
Delta
Deal found 4/27![Delta logo]()
$227
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/262:30 pm
STL
- CHS
1 stop4h 30m
Southwest
Tue 6/23:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 4/28![Southwest logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- CHS
2 stops14h 05m
Multiple Airlines
Tue 6/210:38 am
CHS
- STL
1 stop14h 19m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$234
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/14:19 pm
STL
- CHS
1 stop16h 39m
Multiple Airlines
Fri 6/53:23 pm
CHS
- STL
1 stop9h 34m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$238
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:12 pm
STL
- CHS
1 stop4h 47m
American Airlines
Tue 6/212:58 pm
CHS
- STL
1 stop5h 22m
American Airlines
Deal found 4/30![American Airlines logo]()
$243
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:05 am
STL
- GSP
1 stop4h 00m
Delta
Tue 6/238:52 am
GSP
- STL
1 stop4h 42m
Delta
Deal found 4/28![Delta logo]()
$247
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:19 am
STL
- CHS
1 stop6h 34m
Delta
Mon 6/17:59 pm
CHS
- STL
1 stop5h 00m
Delta
Deal found 4/26![Delta logo]()
$247
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:25 pm
STL
- CLT
1 stop5h 50m
Southwest
Thu 6/44:40 pm
CLT
- STL
Nonstop2h 10m
Southwest
Deal found 4/25![Southwest logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/44:19 pm
STL
- CLT
1 stop25h 33m
Multiple Airlines
Mon 6/89:07 pm
CLT
- STL
2 stops21h 23m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$250
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/262:30 pm
STL
- GSP
1 stop6h 10m
Southwest
Tue 6/212:50 pm
GSP
- STL
2 stops8h 10m
Southwest
Deal found 4/28![Southwest logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:19 pm
STL
- CHS
1 stop15h 29m
Multiple Airlines
Mon 6/13:23 pm
CHS
- STL
1 stop9h 34m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/304:19 pm
STL
- CLT
1 stop25h 33m
Multiple Airlines
Thu 6/46:41 pm
CLT
- STL
2 stops39h 14m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$255
Best flights from St. Louis to South CarolinaDiscover carefully curated flight deals from St. Louis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 30, 2026.
Discover carefully curated flight deals from St. Louis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 30, 2026.
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/39:13 am
STL
- GSP
1 stop4h 02m
Delta
Tue 6/238:52 am
GSP
- STL
1 stop4h 42m
Delta
Deal found 4/27![Delta logo]()
$247
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/303:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Thu 7/25:40 pm
CHS
- STL
1 stop7h 15m
Southwest
Deal found 4/27![Southwest logo]()
$277
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:00 am
STL
- CLT
2 stops7h 12m
United Airlines
Wed 6/248:05 am
CLT
- STL
1 stop5h 06m
United Airlines
Deal found 4/25![United Airlines logo]()
$302
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/92:12 pm
STL
- FLO
1 stop6h 35m
American Airlines
Tue 5/124:02 pm
FLO
- STL
1 stop4h 28m
American Airlines
Deal found 4/29![American Airlines logo]()
$385
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:19 am
STL
- CHS
1 stop6h 34m
Delta
Mon 6/17:59 pm
CHS
- STL
1 stop5h 00m
Delta
Deal found 4/26![Delta logo]()
$247
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:30 pm
STL
- CLT
1 stop6h 10m
Southwest
Fri 5/298:20 am
CLT
- STL
2 stops8h 10m
Southwest
Deal found 4/29![Southwest logo]()
$288
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:05 am
STL
- CLT
1 stop5h 22m
Delta
Sun 5/319:47 am
CLT
- STL
1 stop4h 23m
Delta
Deal found 4/27![Delta logo]()
$270
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/239:21 am
STL
- GSP
1 stop4h 30m
Delta
Sat 6/275:44 am
GSP
- STL
1 stop4h 24m
Delta
Deal found 4/29![Delta logo]()
$272
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:45 am
STL
- CHS
1 stop5h 06m
United Airlines
Fri 5/156:53 pm
CHS
- STL
1 stop4h 57m
United Airlines
Deal found 4/25![United Airlines logo]()
$332
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/232:05 pm
STL
- GSP
2 stops5h 35m
Southwest
Sat 5/3012:25 pm
GSP
- STL
1 stop8h 10m
Southwest
Deal found 4/25![Southwest logo]()
$302
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:35 am
STL
- CLT
2 stops8h 10m
Southwest
Tue 6/93:10 pm
CLT
- STL
2 stops8h 50m
Southwest
Deal found 4/27![Southwest logo]()
$307
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:41 pm
STL
- CLT
1 stop6h 04m
United Airlines
Mon 6/85:51 pm
CLT
- STL
1 stop6h 44m
United Airlines
Deal found 4/28![United Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/133:20 pm
STL
- GSP
1 stop6h 19m
American Airlines
Sat 7/186:43 pm
GSP
- STL
1 stop6h 13m
American Airlines
Deal found 4/25![American Airlines logo]()
$387
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
STL
- CLT
1 stop6h 27m
Delta
Sun 5/315:35 am
CLT
- STL
1 stop3h 43m
Delta
Deal found 4/25![Delta logo]()
$291
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2711:35 am
STL
- CLT
2 stops8h 20m
Southwest
Sat 5/308:10 am
CLT
- STL
2 stops9h 10m
Southwest
Deal found 4/29![Southwest logo]()
$307
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/89:21 am
STL
- CLT
1 stop5h 57m
Delta
Thu 6/117:45 pm
CLT
- STL
1 stop5h 11m
Delta
Deal found 4/25![Delta logo]()
$291
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:00 am
STL
- HHH
1 stop8h 14m
American Airlines
Sat 5/164:10 pm
HHH
- STL
1 stop6h 26m
American Airlines
Deal found 4/28![American Airlines logo]()
$391
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/301:13 pm
STL
- CHS
2 stops9h 43m
United Airlines
Tue 6/211:31 am
CHS
- STL
1 stop5h 15m
United Airlines
Deal found 4/29![United Airlines logo]()
$363
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/154:50 pm
STL
- CLT
Nonstop1h 50m
Southwest
Thu 7/239:15 pm
CLT
- STL
1 stop3h 50m
Southwest
Deal found 4/26![Southwest logo]()
$309
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:14 am
STL
- CAE
1 stop6h 06m
American Airlines
Mon 7/68:30 pm
CAE
- STL
1 stop4h 27m
American Airlines
Deal found 4/25![American Airlines logo]()
$410
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:00 am
STL
- GSP
2 stops7h 20m
United Airlines
Wed 6/106:30 am
GSP
- STL
2 stops10h 16m
United Airlines
Deal found 4/26![United Airlines logo]()
$376
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/127:08 am
STL
- SAV
1 stop6h 40m
Delta
Wed 6/177:08 pm
SAV
- STL
1 stop5h 48m
Delta
Deal found 4/27![Delta logo]()
$334
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/267:15 am
STL
- CHS
1 stop7h 50m
Southwest
Mon 6/297:35 pm
CHS
- STL
1 stop4h 35m
Southwest
Deal found 4/27![Southwest logo]()
$337
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:54 pm
STL
- AGS
1 stop4h 04m
American Airlines
Wed 5/205:00 am
AGS
- STL
2 stops8h 48m
American Airlines
Deal found 4/29![American Airlines logo]()
$417
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/209:21 am
STL
- SAV
1 stop7h 16m
United Airlines
Wed 5/2712:10 pm
SAV
- STL
2 stops10h 11m
United Airlines
Deal found 4/25![United Airlines logo]()
$394
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/187:12 pm
STL
- CHS
1 stop4h 33m
Delta
Mon 6/226:24 pm
CHS
- STL
1 stop4h 54m
Delta
Deal found 4/25![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:10 pm
STL
- CLT
2 stops6h 30m
Southwest
Mon 6/87:10 am
CLT
- STL
2 stops12h 20m
Southwest
Deal found 4/28![Southwest logo]()
$339
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:14 am
STL
- HHH
1 stop4h 56m
American Airlines
Sun 5/242:43 pm
HHH
- STL
1 stop6h 15m
American Airlines
Deal found 4/25![American Airlines logo]()
$429
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:45 am
STL
- SAV
2 stops10h 41m
United Airlines
Wed 5/2012:19 pm
SAV
- STL
1 stop5h 20m
United Airlines
Deal found 4/29![United Airlines logo]()
$401
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1210:51 am
STL
- CHS
1 stop4h 07m
Delta
Fri 6/195:10 am
CHS
- STL
1 stop4h 06m
Delta
Deal found 4/27![Delta logo]()
$337
Last-minute flights from St. Louis to South CarolinaDiscover last-minute flight deals from St. Louis to South Carolina. Data last updated April 30, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to South Carolina. Data last updated April 30, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/143:33 pm
STL
- CLT
2 stops24h 10m
Frontier
Sun 5/177:58 pm
CLT
- STL
1 stop29h 23m
Frontier
Deal found 4/30![Frontier logo]()
$271
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:05 am
STL
- GSP
1 stop6h 10m
Delta
Tue 6/25:40 am
GSP
- STL
1 stop3h 38m
Delta
Deal found 4/25![Delta logo]()
$266
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/262:30 pm
STL
- CHS
1 stop4h 30m
Southwest
Tue 6/22:25 pm
CHS
- STL
1 stop7h 40m
Southwest
Deal found 4/28![Southwest logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- CHS
2 stops14h 05m
Multiple Airlines
Tue 6/210:38 am
CHS
- STL
1 stop14h 19m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$234
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/262:30 pm
STL
- GSP
1 stop6h 10m
Southwest
Tue 6/25:05 pm
GSP
- STL
1 stop5h 55m
Southwest
Deal found 4/28![Southwest logo]()
$247
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:19 am
STL
- CHS
1 stop6h 34m
Delta
Mon 6/17:59 pm
CHS
- STL
1 stop5h 00m
Delta
Deal found 4/26![Delta logo]()
$247
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:20 pm
STL
- CHS
1 stop4h 36m
Delta
Mon 6/15:15 am
CHS
- STL
1 stop4h 03m
Delta
Deal found 4/28![Delta logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:19 pm
STL
- CHS
1 stop15h 29m
Multiple Airlines
Mon 6/13:23 pm
CHS
- STL
1 stop9h 34m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$254
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:12 pm
STL
- CHS
1 stop4h 47m
American Airlines
Tue 6/212:58 pm
CHS
- STL
1 stop5h 22m
American Airlines
Deal found 4/30![American Airlines logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:27 pm
STL
- CLT
2 stops17h 07m
Multiple Airlines
Mon 6/17:57 pm
CLT
- STL
1 stop29h 00m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$266
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:05 am
STL
- CLT
1 stop5h 22m
Delta
Sun 5/319:47 am
CLT
- STL
1 stop4h 23m
Delta
Deal found 4/27![Delta logo]()
$270
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/315:14 am
STL
- CLT
Nonstop1h 54m
American Airlines
Tue 6/910:45 pm
CLT
- STL
Nonstop1h 59m
American Airlines
Deal found 4/29![American Airlines logo]()
$269
One-way flights from St. Louis to South CarolinaSearch for one-way flight options from St. Louis to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 30, 2026.
Search for one-way flight options from St. Louis to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 30, 2026.
This Frontier deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:51 pm
STL
- CLT
1 stop11h 08m
Frontier
Deal found 4/29![Frontier logo]()
$70
This Priceline deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:06 pm
STL
- CLT
1 stop8h 53m
Frontier
Deal found 4/29![Frontier logo]()
$90
This Frontier deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:30 pm
STL
- CLT
1 stop11h 29m
Frontier
Deal found 4/26![Frontier logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:31 pm
STL
- CLT
2 stops26h 04m
Frontier
Deal found 4/29![Frontier logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- CLT
2 stops28h 07m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:27 pm
STL
- CLT
2 stops17h 07m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$107
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/247:12 pm
STL
- CLT
1 stop3h 47m
Delta
Deal found 4/28![Delta logo]()
$109
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/243:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 4/28![Southwest logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:27 pm
STL
- CLT
2 stops19h 44m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:33 pm
STL
- CLT
2 stops40h 32m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/114:19 pm
STL
- CLT
1 stop25h 33m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$113
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:31 pm
STL
- SAV
2 stops38h 54m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$114
Find flight deals from St. Louis to South Carolina
Keep the following information in mind while searching for St. Louis to South Carolina flight deals. Data was last updated April 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $227 (Delta) |
One-way from | $70 (Frontier) |
Popular in | April |
Cheapest in | February |
Average price | $497 |
Good round-trip deal | $315 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
Use the filters below to find and compare flights from St. Louis to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisGreenville
STL - GSP
STLGSP
Lambert-St Louis
Wed 6/3
9:13 am-2:15 pm
1 stop4h 02m
Greenville
Tue 6/23
8:52 am-12:34 pm
1 stop4h 42m
$247
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Wed 5/27
10:19 am-5:53 pm
1 stop6h 34m
Charleston
Mon 6/1
7:59 pm-11:59 pm
1 stop5h 00m
$247
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 5/30
7:05 am-1:27 pm
1 stop5h 22m
Charlotte Douglas
Sun 5/31
9:47 am-1:10 pm
1 stop4h 23m
$270
St. LouisGreenville
STL - GSP
STLGSP
Lambert-St Louis
Tue 6/23
9:21 am-2:51 pm
1 stop4h 30m
Greenville
Sat 6/27
5:44 am-9:08 am
1 stop4h 24m
$272
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 6/30
3:15 pm-6:15 pm
Nonstop2h 00m
Charleston
Thu 7/2
5:40 pm-11:55 pm
1 stop7h 15m
$277
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 5/27
2:30 pm-9:40 pm
1 stop6h 10m
Charlotte Douglas
Fri 5/29
8:20 am-3:30 pm
2 stops8h 10m
$288
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Thu 5/28
6:00 am-1:27 pm
1 stop6h 27m
Charlotte Douglas
Sun 5/31
5:35 am-8:18 am
1 stop3h 43m
$291
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Mon 6/8
9:21 am-4:18 pm
1 stop5h 57m
Charlotte Douglas
Thu 6/11
7:45 pm-11:56 pm
1 stop5h 11m
$291
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 6/17
6:00 am-2:12 pm
2 stops7h 12m
Charlotte Douglas
Wed 6/24
8:05 am-12:11 pm
1 stop5h 06m
$302
St. LouisGreenville
STL - GSP
STLGSP
Lambert-St Louis
Sat 5/23
2:05 pm-8:40 pm
2 stops5h 35m
Greenville
Sat 5/30
12:25 pm-7:35 pm
1 stop8h 10m
$302
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from St. Louis to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from St. Louis with our price prediction graph.
STL-CLT
STL-CHS
STL-SAV
STL-GSP
STL-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to South Carolina
STL-USSC
STL-CLT
STL-CHS
STL-SAV
STL-GSP
How far ahead should I book a flight from St. Louis to South Carolina?
The price you pay for your flight from St. Louis to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 51 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from St. Louis to South Carolina?
Currently, July is the cheapest month in which you can book a flight from St. Louis to South Carolina (average of $89). Flying from St. Louis to South Carolina in January is currently the most expensive (average of $275). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to SC?
Find hourly flight availability from St. Louis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 30, 2026.
When flying from St. Louis to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from St. Louis to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 30, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from St. Louis to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from St. Louis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for St. Louis to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to South Carolina by cabin class
Find flights from St. Louis to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and South Carolina flights
Browse other St. Louis and South Carolina flight options. Last updated on April 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
St. Louis to South Carolina flights
Consider these flights traveling from St. Louis to South Carolina.
Top 4 airlines flying from St. Louis to South Carolina
Discover the top 4 airlines that operate flights from St. Louis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$99 | Average$348 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$193 | Average$396 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$338 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$261 | Average$390 | FlexibilityNo cancel fee | On-time63% |