How popular is this South Carolina to St. Louis flight route?

Within the past month, 3 users have taken a look at flights from South Carolina to Lambert-St Louis.

What are the cheapest airlines to fly from South Carolina to St. Louis one-way?

To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $86. Spirit Airlines flights start at $91 while deals on American Airlines start at $126 one-way.

What are the most popular routes from South Carolina to St. Louis?

The most popular flight routes from South Carolina to St. Louis are Charlotte Douglas - Lambert-St Louis, Charleston - Lambert-St Louis and Columbia Metropolitan - Lambert-St Louis.

What are the cheapest flights from South Carolina to St. Louis?

On average you can expect to pay $361 for a flight from South Carolina to St. Louis. The cheapest flight overall is $143 while the most popular route, (Charlotte Douglas - Lambert-St Louis) is currently priced at $184.

What are the most popular airlines that fly from South Carolina to St. Louis?

Consider American Airlines, Delta or Spirit Airlines when booking your flight. These represent the most popular airlines when flying from South Carolina to St. Louis.

What is the cheapest month to fly from South Carolina to St. Louis?

Due to multiple factors, expect to potentially pay more when booking in April. For low rates, July can be a great choice for travel to St. Louis. Flights to St. Louis from South Carolina in July are about $373 on average during July, but can be found for as low as $262.

What airport do you fly into for flights to St. Louis from South Carolina?

For a flight from South Carolina to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.

Can I find deals for flights from South Carolina to St. Louis that include hotel bookings?

Yes. In addition to deals on South Carolina to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from South Carolina to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to St. Louis.

Can I find deals for business class flights from South Carolina to St. Louis?

Yes. Cheapflights offers flight deals from South Carolina to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$86+ Flights from South Carolina to St. Louis

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Cheap flight deals from South Carolina to St. Louis

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$161 (CheapOair)
One-way from	$86 (Frontier)
Popular in	April
Cheapest in	July
Average price	$432
Good round-trip deal	$336 or less
Good one-way deal	$158 or less

Provider with most accurate pricing for Myrtle Beach Intl-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Myrtle Beach Intl-Lambert-St Louis flights.

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From South Carolina to Lambert-St Louis

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One-way flight from South Carolina to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 6% potential increase in price ($25 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in April 2025

Search Deals

Price to beat on a round-trip flight from South Carolina to Lambert-St Louis.

Search Deals

Price to beat on a one-way flight from South Carolina to Lambert-St Louis.

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Find flight deals from South Carolina to St. Louis

Cheapest flights from South Carolina to St. Louis
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

Fri 5/164:21 pmCLT - STL

1 stop8h 53mFrontier

Sun 5/185:45 pmSTL - CLT

1 stop14h 12mFrontier

Deal found 4/22

$161

Fri 5/164:21 pmCLT - STL

1 stop8h 53mMultiple Airlines

Sat 5/1710:10 amSTL - CLT

1 stop10h 50mMultiple Airlines

Deal found 4/21

$184

Sat 5/315:55 pmCAE - STL

1 stop6h 43mDelta

Sun 6/110:05 amSTL - CAE

1 stop3h 53mDelta

Deal found 4/22

$233

Sat 5/315:24 amCAE - STL

1 stop5h 30mAmerican Airlines

Sun 6/16:47 pmSTL - CAE

1 stop4h 07mAmerican Airlines

Deal found 4/22

$254

Thu 7/2412:18 pmMYR - STL

1 stop20h 31mSpirit Airlines

Mon 7/288:44 amSTL - MYR

1 stop7h 15mSpirit Airlines

Deal found 4/21

$271

Tue 5/207:15 amGSP - STL

1 stop7h 04mDelta

Sun 5/256:45 amSTL - GSP

1 stop4h 01mDelta

Deal found 4/22

$272

Wed 7/3011:56 amHHH - STL

1 stop5h 06mAmerican Airlines

Sun 8/35:26 amSTL - HHH

1 stop5h 01mAmerican Airlines

Deal found 4/22

$279

Tue 7/17:05 pmMYR - STL

1 stop4h 50mSouthwest

Sat 7/54:15 pmSTL - MYR

Nonstop1h 55mSouthwest

Deal found 4/21

$283

Wed 6/1810:58 pmCLT - STL

Nonstop2h 01mAmerican Airlines

Tue 6/245:30 amSTL - CLT

Nonstop1h 55mAmerican Airlines

Deal found 4/21

$287

Wed 7/97:45 pmCHS - STL

Nonstop2h 05mSouthwest

Wed 7/1611:20 amSTL - CHS

Nonstop1h 50mSouthwest

Deal found 4/20

$287

Tue 7/15:00 pmMYR - STL

1 stop4h 30mDelta

Sat 7/510:30 amSTL - MYR

1 stop4h 45mDelta

Deal found 4/22

$293

Wed 7/912:15 pmCHS - STL

1 stop4h 43mDelta

Wed 7/162:18 pmSTL - CHS

1 stop6h 43mDelta

Deal found 4/20

$297

Best flights from South Carolina to St. Louis
Discover carefully curated flight deals from South Carolina to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 22, 2025.

Fri 5/164:21 pmCLT - STL

1 stop8h 53mFrontier

Sun 5/185:45 pmSTL - CLT

1 stop14h 12mFrontier

Deal found 4/22

$161

Fri 5/164:21 pmCLT - STL

1 stop8h 53mMultiple Airlines

Sat 5/1710:10 amSTL - CLT

1 stop10h 50mMultiple Airlines

Deal found 4/21

$184

Sat 5/315:55 pmCAE - STL

1 stop6h 43mDelta

Sun 6/110:05 amSTL - CAE

1 stop3h 53mDelta

Deal found 4/22

$233

Sat 5/315:24 amCAE - STL

1 stop5h 30mAmerican Airlines

Sun 6/16:47 pmSTL - CAE

1 stop4h 07mAmerican Airlines

Deal found 4/22

$254

Tue 7/17:05 pmMYR - STL

1 stop4h 50mSouthwest

Sat 7/54:15 pmSTL - MYR

Nonstop1h 55mSouthwest

Deal found 4/21

$283

Fri 6/275:35 pmGSP - STL

1 stop6h 10mUnited Airlines

Tue 7/110:00 amSTL - GSP

1 stop5h 54mUnited Airlines

Deal found 4/22

$302

Fri 5/99:02 pmCLT - STL

1 stop13h 13mSpirit Airlines

Sun 5/1810:10 amSTL - CLT

2 stops34h 52mSpirit Airlines

Deal found 4/22

$306

Tue 5/207:15 amGSP - STL

1 stop7h 04mDelta

Sun 5/256:45 amSTL - GSP

1 stop4h 01mDelta

Deal found 4/22

$272

Wed 7/3011:56 amHHH - STL

1 stop5h 06mAmerican Airlines

Sun 8/35:26 amSTL - HHH

1 stop5h 01mAmerican Airlines

Deal found 4/22

$279

Wed 7/97:45 pmCHS - STL

Nonstop2h 05mSouthwest

Wed 7/1611:20 amSTL - CHS

Nonstop1h 50mSouthwest

Deal found 4/20

$287

Wed 6/1810:58 pmCLT - STL

Nonstop2h 01mAmerican Airlines

Tue 6/245:30 amSTL - CLT

Nonstop1h 55mAmerican Airlines

Deal found 4/21

$287

Tue 7/15:00 pmMYR - STL

1 stop4h 30mDelta

Sat 7/510:30 amSTL - MYR

1 stop4h 45mDelta

Deal found 4/22

$293

Last-minute flights from South Carolina to St. Louis
Discover last-minute flight deals from South Carolina to St. Louis. Data last updated April 22, 2025 and is based on user searches.

Sun 4/276:00 amCHS - STL

2 stops9h 45mUnited Airlines

Wed 4/308:00 amSTL - CHS

1 stop4h 59mUnited Airlines

Deal found 4/21

$605

Sun 4/279:20 pmCHS - STL

1 stop3h 50mSouthwest

Wed 4/302:20 pmSTL - CHS

Nonstop2h 00mSouthwest

Deal found 4/21

$638

Tue 4/294:52 pmCLT - STL

1 stop18h 09mFrontier

Fri 5/25:55 pmSTL - CLT

1 stop22h 57mFrontier

Deal found 4/22

$201

Tue 4/296:00 amCAE - STL

1 stop6h 56mDelta

Fri 5/26:00 amSTL - CAE

1 stop4h 43mDelta

Deal found 4/21

$661

Tue 4/295:10 amCAE - STL

2 stops7h 14mAmerican Airlines

Fri 5/27:03 pmSTL - CAE

1 stop3h 38mAmerican Airlines

Deal found 4/21

$666

Wed 4/306:15 pmGSP - STL

1 stop4h 35mSouthwest

Fri 5/211:20 amSTL - GSP

1 stop6h 15mSouthwest

Deal found 4/22

$479

Thu 5/110:36 pmCLT - STL

1 stop26h 38mMultiple Airlines

Tue 5/66:10 pmSTL - CLT

1 stop5h 17mMultiple Airlines

Deal found 4/22

$234

Thu 5/17:35 amCLT - STL

Nonstop1h 55mAmerican Airlines

Wed 5/71:59 pmSTL - CLT

Nonstop1h 58mAmerican Airlines

Deal found 4/22

$446

Thu 5/17:00 amCLT - STL

2 stops8h 47mUnited Airlines

Wed 5/78:25 amSTL - CLT

1 stop4h 46mUnited Airlines

Deal found 4/22

$539

Fri 5/24:20 pmCLT - STL

Nonstop2h 05mSouthwest

Sun 5/44:25 pmSTL - CLT

Nonstop1h 50mSouthwest

Deal found 4/20

$499

Fri 5/210:11 amGSP - STL

1 stop5h 49mDelta

Sun 5/45:32 pmSTL - GSP

1 stop5h 21mDelta

Deal found 4/22

$527

Fri 5/23:55 pmGSP - STL

3 stops45h 15mMultiple Airlines

Sun 5/46:10 pmSTL - GSP

1 stop19h 55mMultiple Airlines

Deal found 4/22

$603

One-way flights from South Carolina to St. Louis
Search for one-way flight options from South Carolina to St. Louis. Find affordable one-way fares based on user searches. Data last updated April 22, 2025.

Mon 5/194:21 pmCLT - STL

1 stop8h 45mFrontier

Deal found 4/21

$86

Sat 5/249:43 amCHS - STL

1 stop24h 32mSpirit Airlines

Deal found 4/21

$91

Fri 6/136:10 amMYR - STL

1 stop5h 23mSpirit Airlines

Deal found 4/22

$97

Fri 5/912:34 pmSAV - STL

1 stop21h 41mMultiple Airlines

Deal found 4/22

$105

Wed 6/46:17 pmCLT - STL

1 stop15h 58mSpirit Airlines

Deal found 4/21

$124

Tue 7/11:01 pmCLT - STL

1 stop8h 29mAmerican Airlines

Deal found 4/22

$126

Tue 7/17:45 pmCHS - STL

Nonstop2h 05mSouthwest

Deal found 4/22

$128

Thu 5/1512:11 pmSAV - STL

1 stop24h 26mSun Country Air

Deal found 4/22

$133

Tue 5/207:39 amCHS - STL

1 stop5h 25mDelta

Deal found 4/20

$133

Sat 5/2411:20 amMYR - STL

Nonstop2h 20mSouthwest

Deal found 4/21

$137

Sat 5/244:40 pmCLT - STL

1 stop4h 59mDelta

Deal found 4/21

$138

Fri 7/411:14 amCHS - STL

2 stops6h 53mAmerican Airlines

Deal found 4/22

$143

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Fri 5/16

4:21 pm-12:14 am

1 stop8h 53m

Lambert-St Louis

Sun 5/18

5:45 pm-8:57 am

1 stop14h 12m

$161

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Fri 5/16

4:21 pm-12:14 am

1 stop8h 53m

Lambert-St Louis

Sat 5/17

10:10 am-10:00 pm

1 stop10h 50m

$184

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Sat 5/31

5:55 pm-11:38 pm

1 stop6h 43m

Lambert-St Louis

Sun 6/1

10:05 am-2:58 pm

1 stop3h 53m

$233

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Sat 5/31

5:24 am-9:54 am

1 stop5h 30m

Lambert-St Louis

Sun 6/1

6:47 pm-11:54 pm

1 stop4h 07m

$254

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Tue 5/20

7:15 am-1:19 pm

1 stop7h 04m

Lambert-St Louis

Sun 5/25

6:45 am-11:46 am

1 stop4h 01m

$272

Hilton Head IslandSt. Louis

HHH - STL

HHHSTL

Hilton Head Island

Wed 7/30

11:56 am-4:02 pm

1 stop5h 06m

Lambert-St Louis

Sun 8/3

5:26 am-11:27 am

1 stop5h 01m

$279

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Tue 7/1

7:05 pm-10:55 pm

1 stop4h 50m

Lambert-St Louis

Sat 7/5

4:15 pm-7:10 pm

Nonstop1h 55m

$283

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Wed 7/9

7:45 pm-8:50 pm

Nonstop2h 05m

Lambert-St Louis

Wed 7/16

11:20 am-2:10 pm

Nonstop1h 50m

$287

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Wed 6/18

10:58 pm-11:59 pm

Nonstop2h 01m

Lambert-St Louis

Tue 6/24

5:30 am-8:25 am

Nonstop1h 55m

$287

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Tue 7/1

5:00 pm-8:30 pm

1 stop4h 30m

Lambert-St Louis

Sat 7/5

10:30 am-4:15 pm

1 stop4h 45m

$293

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/21

Showing 1-10 of 60 results

...

Best time to book a flight from South Carolina to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to St. Louis

What is the cheapest month to book a flight from South Carolina to St. Louis?

Currently, August is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $311). Flying from South Carolina to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to STL?

When flying from South Carolina to St. Louis, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in St. Louis by month

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Read through reviews of airlines operating flights from South Carolina to St. Louis, such as Alaska Airlines, Southwest and Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Alaska Airlines

8.0

Very good

9,911 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Alaska Airlines

8.0

Very good

9,911 reviews

Alaska Airlines

8.0

Very good

9,911 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Southwest

8.0

Very good

4,287 reviews

Alaska Airlines

8.0

Very good

9,911 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Delta

8.0

Very good

7,920 reviews

Alaska Airlines

8.0

Very good

9,911 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

United Airlines

7.4

Good

8,683 reviews

Alaska Airlines

8.0

Very good

9,911 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

American Airlines

7.2

Good

10,000 reviews

Alaska Airlines

8.0

Very good

9,911 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Related info for your journey

What airport do you fly into for flights to St. Louis from South Carolina?
For a flight from South Carolina to St. Louis, you will be flying into Lambert-St Louis. Lambert-St Louis (STL) is just 12.7 mi from the center of the city.
How popular is this South Carolina to St. Louis flight route?
Within the past month, 3 users have taken a look at flights from South Carolina to Lambert-St Louis.
What are the cheapest airlines to fly from South Carolina to St. Louis one-way?
To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $86. Spirit Airlines flights start at $91 while deals on American Airlines start at $126 one-way.
What are the most popular routes from South Carolina to St. Louis?
The most popular flight routes from South Carolina to St. Louis are Charlotte Douglas - Lambert-St Louis, Charleston - Lambert-St Louis and Columbia Metropolitan - Lambert-St Louis.
What are the cheapest flights from South Carolina to St. Louis?
On average you can expect to pay $361 for a flight from South Carolina to St. Louis. The cheapest flight overall is $143 while the most popular route, (Charlotte Douglas - Lambert-St Louis) is currently priced at $184.
Can I find deals for flights from South Carolina to St. Louis that include hotel bookings?
Yes. In addition to deals on South Carolina to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from South Carolina to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to St. Louis.
Can I find deals for business class flights from South Carolina to St. Louis?
Yes. Cheapflights offers flight deals from South Carolina to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from South Carolina to St. Louis?
Currently, August is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $311). Flying from South Carolina to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Fenton

Maryland Heights

Fairview Heights

Collinsville

Wentzville

Eureka

St. Peters

Festus

Glencoe

Alton

Farmington

Browse thousands of different options on Cheapflights for your next trip

Top 4 airlines flying from South Carolina to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$139	Average$201	FlexibilityNo cancel fee	On-time65%
American Airlines	Cheapest$172	Average$357	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$238	Average$362	FlexibilityNo cancel fee	On-timeN/A
Southwest	Cheapest$286	Average$364	FlexibilityNo cancel fee	On-time63%

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$86+ Cheap flights from South Carolina to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from South Carolina to St. Louis with Cheapflights

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3. Compare prices and book

Cheap flight deals from South Carolina to St. Louis

Keep the following information in mind while searching for South Carolina to St. Louis flight deals. Data was last updated April 22, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from South Carolina to St. Louis

Cheapest flights from South Carolina to St. LouisExplore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.

Best time to book a flight from South Carolina to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to St. Louis

What is the cheapest month to book a flight from South Carolina to St. Louis?

What is the cheapest time of day to fly from SC to STL?

Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 22, 2025.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

Reviews of airlines servicing St. Louis

Read through reviews of airlines operating flights from South Carolina to St. Louis, such as Alaska Airlines, Southwest and Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to St. Louis from South Carolina?

How popular is this South Carolina to St. Louis flight route?

What are the cheapest airlines to fly from South Carolina to St. Louis one-way?

What are the most popular routes from South Carolina to St. Louis?

What are the cheapest flights from South Carolina to St. Louis?

Can I find deals for flights from South Carolina to St. Louis that include hotel bookings?

How can I find direct flights from South Carolina to St. Louis?

Can I find deals for business class flights from South Carolina to St. Louis?

What is the cheapest month to book a flight from South Carolina to St. Louis?

Traveling to a place near South Carolina?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to St. Louis

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from South Carolina to St. Louis

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Cheapest flights from South Carolina to St. Louis
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.