$95+ Cheap flights from South Carolina to St. Louis (STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Jul 16 — Jul 231
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to St. LouisExplore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2026.
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2026.
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/47:37 am
CLT
- STL
Nonstop1h 56m
American Airlines
Sat 8/86:54 am
STL
- CLT
Nonstop1h 55m
American Airlines
Deal found 6/11![American Airlines logo]()
$189
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:37 am
CLT
- STL
Nonstop1h 56m
American Airlines
Wed 7/156:13 pm
STL
- CLT
Nonstop1h 58m
American Airlines
Deal found 6/16![American Airlines logo]()
$197
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Wed 7/1510:15 am
STL
- CLT
1 stop6h 35m
Southwest
Deal found 6/15![Southwest logo]()
$207
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:45 am
CLT
- STL
1 stop6h 01m
Delta
Wed 8/126:00 am
STL
- CLT
1 stop4h 03m
Delta
Deal found 6/11![Delta logo]()
$209
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Tue 7/145:40 am
STL
- CLT
2 stops7h 55m
Southwest
Deal found 6/14![Southwest logo]()
$212
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:30 am
CLT
- STL
1 stop3h 49m
Delta
Tue 7/213:58 pm
STL
- CLT
1 stop7h 00m
Delta
Deal found 6/16![Delta logo]()
$217
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Tue 7/213:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/15![Southwest logo]()
$217
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:40 am
CLT
- STL
2 stops8h 45m
Southwest
Tue 7/215:40 am
STL
- CLT
2 stops7h 55m
Southwest
Deal found 6/15![Southwest logo]()
$227
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/59:45 pm
CLT
- STL
Nonstop1h 55m
American Airlines
Wed 8/126:00 am
STL
- CLT
1 stop5h 03m
American Airlines
Deal found 6/12![American Airlines logo]()
$231
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:30 am
CHS
- STL
1 stop3h 42m
Delta
Tue 10/136:00 am
STL
- CHS
1 stop4h 26m
Delta
Deal found 6/11![Delta logo]()
$243
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:50 pm
GSP
- STL
1 stop6h 25m
Southwest
Wed 7/153:10 pm
STL
- GSP
1 stop5h 55m
Southwest
Deal found 6/15![Southwest logo]()
$249
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:30 am
CHS
- STL
1 stop5h 06m
Delta
Mon 9/146:45 pm
STL
- CHS
1 stop4h 12m
Delta
Deal found 6/12![Delta logo]()
$255
Best flights from South Carolina to St. LouisDiscover carefully curated flight deals from South Carolina to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 16, 2026.
Discover carefully curated flight deals from South Carolina to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 16, 2026.
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:45 am
CLT
- STL
1 stop6h 01m
Delta
Wed 8/126:00 am
STL
- CLT
1 stop4h 03m
Delta
Deal found 6/11![Delta logo]()
$209
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/148:15 pm
CHS
- STL
1 stop3h 50m
Southwest
Tue 7/218:25 am
STL
- CHS
1 stop6h 10m
Southwest
Deal found 6/11![Southwest logo]()
$247
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/118:05 am
CLT
- STL
1 stop4h 57m
United Airlines
Wed 8/127:25 am
STL
- CLT
1 stop6h 29m
United Airlines
Deal found 6/15![United Airlines logo]()
$297
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:06 am
AGS
- STL
1 stop6h 09m
American Airlines
Sat 9/261:54 pm
STL
- AGS
1 stop3h 49m
American Airlines
Deal found 6/11![American Airlines logo]()
$331
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:50 pm
GSP
- STL
1 stop6h 25m
Southwest
Wed 7/153:10 pm
STL
- GSP
1 stop5h 55m
Southwest
Deal found 6/15![Southwest logo]()
$249
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:35 am
SAV
- STL
1 stop4h 19m
Delta
Mon 8/106:00 am
STL
- SAV
1 stop4h 40m
Delta
Deal found 6/11![Delta logo]()
$267
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:30 pm
GSP
- STL
1 stop5h 40m
Southwest
Wed 8/57:15 am
STL
- GSP
1 stop4h 10m
Southwest
Deal found 6/11![Southwest logo]()
$249
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:00 am
CLT
- STL
2 stops7h 11m
United Airlines
Wed 8/126:00 am
STL
- CLT
2 stops8h 18m
United Airlines
Deal found 6/11![United Airlines logo]()
$300
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/611:50 am
CLT
- STL
Nonstop1h 55m
Southwest
Mon 8/103:45 pm
STL
- CLT
1 stop5h 05m
Southwest
Deal found 6/15![Southwest logo]()
$255
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:00 pm
CHS
- STL
1 stop6h 15m
Delta
Fri 7/246:58 pm
STL
- CHS
1 stop4h 28m
Delta
Deal found 6/12![Delta logo]()
$287
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/42:53 pm
CLT
- STL
2 stops9h 43m
United Airlines
Sat 8/89:20 am
STL
- CLT
1 stop7h 39m
United Airlines
Deal found 6/14![United Airlines logo]()
$302
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/248:30 pm
CAE
- STL
1 stop4h 14m
American Airlines
Sat 6/2712:39 pm
STL
- CAE
1 stop4h 35m
American Airlines
Deal found 6/11![American Airlines logo]()
$348
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/61:05 pm
SAV
- STL
1 stop7h 15m
Southwest
Mon 8/1011:40 am
STL
- SAV
2 stops9h 15m
Southwest
Deal found 6/11![Southwest logo]()
$273
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:47 pm
CAE
- STL
1 stop5h 20m
Delta
Mon 7/67:12 pm
STL
- CAE
1 stop3h 34m
Delta
Deal found 6/15![Delta logo]()
$302
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:00 am
CHS
- STL
1 stop5h 17m
United Airlines
Wed 8/268:00 am
STL
- CHS
1 stop4h 58m
United Airlines
Deal found 6/15![United Airlines logo]()
$317
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/142:35 pm
FLO
- STL
1 stop3h 46m
American Airlines
Tue 7/219:25 am
STL
- FLO
1 stop3h 45m
American Airlines
Deal found 6/16![American Airlines logo]()
$350
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2711:50 am
CLT
- STL
Nonstop1h 55m
Southwest
Sun 8/303:05 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 6/15![Southwest logo]()
$274
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:43 am
SAV
- STL
1 stop4h 00m
Delta
Fri 7/246:58 pm
STL
- SAV
1 stop3h 55m
Delta
Deal found 6/15![Delta logo]()
$317
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:30 am
AGS
- STL
1 stop6h 25m
American Airlines
Wed 7/225:02 pm
STL
- AGS
1 stop5h 57m
American Airlines
Deal found 6/13![American Airlines logo]()
$351
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/181:55 pm
GSP
- STL
1 stop9h 10m
Southwest
Tue 7/213:10 pm
STL
- GSP
1 stop5h 55m
Southwest
Deal found 6/15![Southwest logo]()
$278
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:39 am
SAV
- STL
1 stop3h 40m
Delta
Tue 7/211:22 pm
STL
- SAV
1 stop4h 37m
Delta
Deal found 6/15![Delta logo]()
$317
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:10 pm
MYR
- STL
2 stops7h 06m
American Airlines
Tue 7/217:32 am
STL
- MYR
1 stop6h 59m
American Airlines
Deal found 6/11![American Airlines logo]()
$368
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/22:47 pm
CHS
- STL
2 stops9h 57m
United Airlines
Tue 7/71:13 pm
STL
- CHS
1 stop7h 35m
United Airlines
Deal found 6/15![United Airlines logo]()
$372
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2010:50 am
GSP
- STL
2 stops7h 50m
Southwest
Sat 10/2411:30 am
STL
- GSP
1 stop4h 50m
Southwest
Deal found 6/12![Southwest logo]()
$294
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/115:31 pm
SAV
- STL
1 stop4h 06m
Delta
Mon 7/136:58 pm
STL
- SAV
1 stop3h 55m
Delta
Deal found 6/13![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:59 pm
MYR
- STL
1 stop5h 39m
United Airlines
Wed 8/127:25 am
STL
- MYR
1 stop6h 28m
United Airlines
Deal found 6/13![United Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/85:17 am
FLO
- STL
2 stops12h 23m
American Airlines
Tue 7/147:32 am
STL
- FLO
1 stop5h 38m
American Airlines
Deal found 6/14![American Airlines logo]()
$381
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:35 am
CHS
- STL
2 stops8h 55m
Southwest
Wed 7/221:45 pm
STL
- CHS
1 stop5h 45m
Southwest
Deal found 6/11![Southwest logo]()
$297
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:07 pm
SAV
- STL
1 stop5h 46m
Delta
Mon 7/273:58 pm
STL
- SAV
1 stop5h 51m
Delta
Deal found 6/14![Delta logo]()
$337
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:17 am
FLO
- STL
1 stop4h 16m
American Airlines
Wed 7/159:25 am
STL
- FLO
1 stop3h 45m
American Airlines
Deal found 6/14![American Airlines logo]()
$384
Last-minute flights from South Carolina to St. LouisDiscover last-minute flight deals from South Carolina to St. Louis. Data last updated June 16, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to St. Louis. Data last updated June 16, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:37 am
CLT
- STL
Nonstop1h 56m
American Airlines
Wed 7/156:13 pm
STL
- CLT
Nonstop1h 58m
American Airlines
Deal found 6/16![American Airlines logo]()
$197
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Wed 7/1510:15 am
STL
- CLT
1 stop6h 35m
Southwest
Deal found 6/15![Southwest logo]()
$207
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Tue 7/145:40 am
STL
- CLT
2 stops7h 55m
Southwest
Deal found 6/14![Southwest logo]()
$212
This CheapOair deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/812:24 pm
CLT
- STL
1 stop12h 35m
Frontier
Wed 7/154:09 pm
STL
- CLT
1 stop23h 49m
Frontier
Deal found 6/15![Frontier logo]()
$240
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/93:15 pm
CHS
- STL
1 stop7h 40m
Southwest
Tue 7/143:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/14![Southwest logo]()
$277
This CheapOair deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/1210:59 pm
CLT
- STL
1 stop26h 00m
Frontier
Tue 7/144:09 pm
STL
- CLT
1 stop23h 49m
Frontier
Deal found 6/12![Frontier logo]()
$246
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:30 am
CLT
- STL
1 stop3h 49m
Delta
Tue 7/213:58 pm
STL
- CLT
1 stop7h 00m
Delta
Deal found 6/16![Delta logo]()
$217
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Tue 7/213:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/15![Southwest logo]()
$217
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:40 am
CLT
- STL
2 stops8h 45m
Southwest
Tue 7/215:40 am
STL
- CLT
2 stops7h 55m
Southwest
Deal found 6/15![Southwest logo]()
$227
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:50 pm
GSP
- STL
1 stop6h 25m
Southwest
Wed 7/153:10 pm
STL
- GSP
1 stop5h 55m
Southwest
Deal found 6/15![Southwest logo]()
$249
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/255:28 pm
GSP
- STL
1 stop7h 30m
American Airlines
Tue 7/285:58 pm
STL
- GSP
1 stop5h 00m
American Airlines
Deal found 6/15![American Airlines logo]()
$273
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/287:00 am
GSP
- STL
2 stops7h 05m
Southwest
Wed 7/2910:15 am
STL
- GSP
2 stops9h 05m
Southwest
Deal found 6/15![Southwest logo]()
$259
One-way flights from South Carolina to St. LouisSearch for one-way flight options from South Carolina to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 16, 2026.
Search for one-way flight options from South Carolina to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 16, 2026.
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:20 pm
CLT
- STL
Nonstop2h 10m
Southwest
Deal found 6/11![Southwest logo]()
$95
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/14![Southwest logo]()
$99
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:35 pm
CLT
- STL
1 stop4h 05m
Southwest
Deal found 6/11![Southwest logo]()
$105
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/119:33 am
CLT
- STL
1 stop6h 00m
Delta
Deal found 6/16![Delta logo]()
$109
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/810:30 am
CHS
- STL
1 stop6h 27m
Delta
Deal found 6/11![Delta logo]()
$111
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:35 am
SAV
- STL
1 stop5h 19m
Delta
Deal found 6/11![Delta logo]()
$113
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:50 am
CLT
- STL
2 stops9h 00m
Southwest
Deal found 6/12![Southwest logo]()
$114
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:00 pm
CHS
- STL
1 stop6h 15m
Delta
Deal found 6/15![Delta logo]()
$114
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/811:00 am
CHS
- STL
2 stops7h 20m
Southwest
Deal found 6/11![Southwest logo]()
$117
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:45 am
SAV
- STL
2 stops9h 20m
Southwest
Deal found 6/11![Southwest logo]()
$118
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/911:37 am
CHS
- STL
1 stop5h 01m
United Airlines
Deal found 6/12![United Airlines logo]()
$119
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1311:50 am
CLT
- STL
Nonstop1h 55m
Southwest
Deal found 6/16![Southwest logo]()
$123
Find flight deals from South Carolina to St. Louis
Keep the following information in mind while searching for South Carolina to St. Louis flight deals. Data was last updated June 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $189 (American Airlines) |
One-way from | $95 (Southwest) |
Popular in | December |
Cheapest in | August |
Average price | $379 |
Good round-trip deal | $336 or less |
Good one-way deal | $203 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 8/5
6:45 am-11:46 am
1 stop6h 01m
Lambert-St Louis
Wed 8/12
6:00 am-11:03 am
1 stop4h 03m
$209
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Tue 7/14
8:15 pm-11:05 pm
1 stop3h 50m
Lambert-St Louis
Tue 7/21
8:25 am-3:35 pm
1 stop6h 10m
$247
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Tue 7/14
1:50 pm-7:15 pm
1 stop6h 25m
Lambert-St Louis
Wed 7/15
3:10 pm-10:05 pm
1 stop5h 55m
$249
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Tue 8/4
5:30 pm-10:10 pm
1 stop5h 40m
Lambert-St Louis
Wed 8/5
7:15 am-12:25 pm
1 stop4h 10m
$249
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Thu 8/6
11:50 am-12:45 pm
Nonstop1h 55m
Lambert-St Louis
Mon 8/10
3:45 pm-9:50 pm
1 stop5h 05m
$255
SavannahSt. Louis
SAV - STL
SAVSTL
Savannah/Hilton Head
Thu 8/6
6:35 am-9:54 am
1 stop4h 19m
Lambert-St Louis
Mon 8/10
6:00 am-11:40 am
1 stop4h 40m
$267
SavannahSt. Louis
SAV - STL
SAVSTL
Savannah/Hilton Head
Thu 8/6
1:05 pm-7:20 pm
1 stop7h 15m
Lambert-St Louis
Mon 8/10
11:40 am-9:55 pm
2 stops9h 15m
$273
Quickest round-trip
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Thu 8/27
11:50 am-12:45 pm
Nonstop1h 55m
Lambert-St Louis
Sun 8/30
3:05 pm-5:55 pm
Nonstop1h 50m
$274
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Sat 7/18
1:55 pm-10:05 pm
1 stop9h 10m
Lambert-St Louis
Tue 7/21
3:10 pm-10:05 pm
1 stop5h 55m
$278
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Tue 7/21
5:00 pm-10:15 pm
1 stop6h 15m
Lambert-St Louis
Fri 7/24
6:58 pm-12:26 am
1 stop4h 28m
$287
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.
CLT-STL
CHS-STL
AGS-STL
GSP-STL
SAV-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to St. Louis
USSC-STL
CLT-STL
CHS-STL
AGS-STL
GSP-STL
What is the cheapest month to book a flight from South Carolina to St. Louis?
Currently, October is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $158). Flying from South Carolina to St. Louis in January is currently the most expensive (average of $299). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to STL?
Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 16, 2026.
One of the essential ways to save on airfare from South Carolina to St. Louis is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 48% on airfare.
How much does it cost to fly round-trip from South Carolina to St. Louis?
Related info for your journey
Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for South Carolina to St. Louis
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Complete your trip
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South Carolina and St. Louis flights
Browse other South Carolina and St. Louis flight options. Last updated on June 16, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 16, 2026.
South Carolina to St. Louis flights
Consider these flights traveling from South Carolina to St. Louis.
Top 3 airlines flying from South Carolina to St. Louis
Discover the top 3 airlines that operate flights from South Carolina to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$206 | Average$358 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$229 | Average$389 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$281 | Average$377 | FlexibilityNo cancel fee | On-time63% |