$84+ Cheap flights from South Carolina to St. Louis (STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/19. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Oct 24 — Oct 311
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from South Carolina to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from South Carolina to St. LouisExplore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:16 am -
1 stop6h 19m
Wed 10/281:20 pm -
1 stop7h 49m
Deal found 9/22![American Airlines logo]()
$187
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:00 am -
1 stop4h 55m
Wed 11/182:54 pm -
1 stop6h 32m
Deal found 9/22![American Airlines logo]()
$206
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:00 am -
1 stop8h 04m
Tue 11/106:30 am -
1 stop3h 53m
Deal found 9/21![American Airlines logo]()
$207
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/214:58 pm -
1 stop5h 23m
Wed 10/281:00 pm -
1 stop5h 11m
Deal found 9/23![United Airlines logo]()
$222
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:04 pm -
1 stop5h 55m
Mon 10/261:20 pm -
1 stop7h 49m
Deal found 9/21![American Airlines logo]()
$227
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/211:55 pm -
2 stops7h 05m
Wed 10/282:10 pm -
1 stop4h 25m
Deal found 9/23![Southwest logo]()
$232
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:30 am -
2 stops7h 15m
Tue 11/1010:15 am -
2 stops8h 50m
Deal found 9/19![Southwest logo]()
$237
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:40 pm -
1 stop4h 00m
Wed 10/218:10 am -
1 stop3h 30m
Deal found 9/21![Southwest logo]()
$259
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:00 pm -
1 stop5h 24m
Mon 11/166:00 am -
1 stop7h 27m
Deal found 9/19![United Airlines logo]()
$266
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/213:29 pm -
1 stop7h 45m
Fri 11/275:00 am -
1 stop4h 35m
Deal found 9/22![American Airlines logo]()
$272
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:04 pm -
1 stop5h 55m
Sun 11/16:00 am -
1 stop7h 39m
Deal found 9/22![American Airlines logo]()
$286
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:25 pm -
1 stop7h 17m
Tue 11/37:00 am -
1 stop6h 56m
Deal found 9/20![American Airlines logo]()
$287
Best flights from South Carolina to St. LouisDiscover carefully curated flight deals from South Carolina to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
Discover carefully curated flight deals from South Carolina to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:00 am -
1 stop5h 40m
Tue 11/1012:40 pm -
1 stop6h 25m
Deal found 9/19![Southwest logo]()
$227
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:00 pm -
1 stop5h 24m
Mon 11/166:00 am -
1 stop7h 27m
Deal found 9/19![United Airlines logo]()
$266
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:00 am -
1 stop4h 51m
Tue 11/2412:29 pm -
1 stop3h 41m
Deal found 9/21![Delta logo]()
$356
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/108:12 pm -
1 stop4h 47m
Tue 10/1310:48 am -
1 stop7h 42m
Deal found 9/19![American Airlines logo]()
$357
This Southwest deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:40 pm -
1 stop4h 00m
Wed 10/218:10 am -
1 stop3h 30m
Deal found 9/20![Southwest logo]()
$259
This Southwest deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:10 pm -
2 stops5h 55m
Tue 11/312:40 pm -
1 stop6h 10m
Deal found 9/20![Southwest logo]()
$288
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:00 am -
2 stops9h 43m
Sat 10/316:00 am -
2 stops7h 23m
Deal found 9/21![United Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:35 am -
1 stop6h 25m
Mon 10/264:30 pm -
Nonstop1h 55m
Deal found 9/21![Southwest logo]()
$288
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:34 pm -
1 stop5h 44m
Mon 11/210:35 am -
1 stop3h 34m
Deal found 9/21![American Airlines logo]()
$373
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/115:40 am -
1 stop4h 29m
Tue 11/247:08 am -
1 stop5h 06m
Deal found 9/21![Delta logo]()
$374
This Southwest deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/131:00 pm -
2 stops7h 10m
Mon 11/164:30 pm -
1 stop3h 20m
Deal found 9/20![Southwest logo]()
$292
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1710:38 am -
2 stops9h 22m
Tue 10/275:00 am -
2 stops11h 11m
Deal found 9/22![United Airlines logo]()
$357
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:00 am -
1 stop4h 51m
Sat 10/1012:00 pm -
1 stop3h 26m
Deal found 9/22![Delta logo]()
$387
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:02 am -
1 stop7h 44m
Sun 10/255:00 am -
1 stop4h 33m
Deal found 9/23![American Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/103:03 pm -
2 stops7h 18m
Thu 11/267:30 am -
1 stop5h 37m
Deal found 9/21![United Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:10 am -
1 stop4h 10m
Mon 11/22:25 pm -
1 stop4h 45m
Deal found 9/20![Delta logo]()
$389
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:40 pm -
1 stop4h 00m
Sun 11/11:20 pm -
1 stop5h 50m
Deal found 9/19![Southwest logo]()
$328
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/132:13 pm -
2 stops7h 39m
Tue 10/2010:22 am -
1 stop5h 19m
Deal found 9/20![American Airlines logo]()
$408
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:59 pm -
1 stop4h 24m
Mon 10/266:00 am -
1 stop3h 43m
Deal found 9/21![Delta logo]()
$389
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:37 pm -
1 stop5h 03m
Fri 10/301:08 pm -
2 stops8h 52m
Deal found 9/23![United Airlines logo]()
$413
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:50 pm -
1 stop4h 30m
Mon 10/261:00 pm -
1 stop7h 30m
Deal found 9/19![Southwest logo]()
$347
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:11 pm -
1 stop6h 53m
Wed 10/75:00 am -
1 stop5h 05m
Deal found 9/19![American Airlines logo]()
$451
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:37 am -
1 stop7h 22m
Wed 11/48:00 am -
1 stop5h 17m
Deal found 9/23![United Airlines logo]()
$425
This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:40 pm -
1 stop4h 50m
Tue 10/2710:55 am -
2 stops8h 15m
Deal found 9/22![Southwest logo]()
$352
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/223:55 pm -
2 stops8h 25m
Thu 10/291:00 pm -
1 stop7h 30m
Deal found 9/23![Southwest logo]()
$352
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/612:23 pm -
2 stops9h 28m
Wed 10/710:14 am -
1 stop4h 16m
Deal found 9/19![Delta logo]()
$524
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:40 pm -
1 stop4h 50m
Fri 10/232:30 pm -
1 stop6h 15m
Deal found 9/21![Southwest logo]()
$366
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1310:23 am -
2 stops10h 00m
Sun 11/157:30 am -
1 stop5h 26m
Deal found 9/20![United Airlines logo]()
$490
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:55 pm -
1 stop4h 00m
Mon 11/91:20 pm -
1 stop6h 00m
Deal found 9/23![Southwest logo]()
$366
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:35 am -
1 stop6h 25m
Sun 10/255:25 pm -
Nonstop1h 55m
Deal found 9/23![Southwest logo]()
$385
Last-minute flights from South Carolina to St. LouisDiscover last-minute flight deals from South Carolina to St. Louis. Data last updated September 24, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to St. Louis. Data last updated September 24, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/138:30 am -
2 stops7h 25m
Sat 10/179:25 am -
1 stop9h 10m
Deal found 9/18![Southwest logo]()
$307
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:40 pm -
1 stop4h 00m
Wed 10/218:10 am -
1 stop3h 30m
Deal found 9/21![Southwest logo]()
$259
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:04 pm -
1 stop5h 55m
Mon 10/261:20 pm -
1 stop7h 49m
Deal found 9/21![American Airlines logo]()
$227
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:35 am -
1 stop6h 25m
Mon 10/264:30 pm -
Nonstop1h 55m
Deal found 9/21![Southwest logo]()
$288
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/214:58 pm -
1 stop5h 23m
Wed 10/281:00 pm -
1 stop5h 11m
Deal found 9/23![United Airlines logo]()
$222
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/211:55 pm -
2 stops7h 05m
Wed 10/282:10 pm -
1 stop4h 25m
Deal found 9/23![Southwest logo]()
$232
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/233:53 pm -
1 stop6h 04m
Sun 10/255:40 am -
1 stop8h 04m
Deal found 9/22![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:16 am -
1 stop6h 19m
Wed 10/281:20 pm -
1 stop7h 49m
Deal found 9/22![American Airlines logo]()
$187
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:19 pm -
1 stop5h 05m
Sat 10/319:40 am -
1 stop7h 24m
Deal found 9/22![United Airlines logo]()
$327
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:04 pm -
1 stop5h 55m
Sun 11/16:00 am -
1 stop7h 39m
Deal found 9/22![American Airlines logo]()
$286
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:25 pm -
1 stop7h 17m
Tue 11/37:00 am -
1 stop6h 56m
Deal found 9/20![American Airlines logo]()
$287
This Southwest deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:10 pm -
2 stops5h 55m
Tue 11/312:40 pm -
1 stop6h 10m
Deal found 9/20![Southwest logo]()
$288
One-way flights from South Carolina to St. LouisSearch for one-way flight options from South Carolina to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
Search for one-way flight options from South Carolina to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:04 pm -
1 stop5h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![American Airlines logo]()
$84
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop5h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$94
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/203:18 pm -
2 stops27h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Multiple Airlines logo]()
$96
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2011:28 am -
2 stops31h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Multiple Airlines logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:00 am -
2 stops12h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$109
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:00 am -
1 stop5h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![United Airlines logo]()
$114
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/214:20 pm -
1 stop5h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Delta logo]()
$119
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:08 pm -
1 stop4h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![American Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:45 am -
2 stops35h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:13 pm -
2 stops29h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2010:45 am -
2 stops31h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1310:44 am -
2 stops31h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Multiple Airlines logo]()
$127
Find flight deals from South Carolina to St. Louis
Keep the following information in mind while searching for South Carolina to St. Louis flight deals. Data was last updated September 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $187 (American Airlines) |
One-way from | $84 (American Airlines) |
Popular in | June |
Cheapest in | February |
Average price | $352 |
Good round-trip deal | $301 or less |
Good one-way deal | $229 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Sat 10/17
7:00 am-11:33 am
1 stop5h 33m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$114
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Thu 11/19
1:30 pm-6:05 pm
1 stop5h 35m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$114
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Wed 11/18
3:29 pm-9:40 pm
1 stop7h 11m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$114
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Sat 10/17
7:02 am-10:51 am
1 stop4h 49m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$119
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Thu 10/22
5:30 am-10:51 am
1 stop6h 21m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$119
Quickest round-trip
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Sat 10/24
7:02 am-9:42 am
1 stop3h 40m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$119
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Wed 10/21
6:00 am-2:17 pm
2 stops9h 17m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$119
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Tue 10/20
11:15 am-4:28 pm
1 stop6h 13m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$119
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Thu 12/17
12:55 pm-6:13 pm
1 stop6h 18m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$119
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Tue 11/17
5:20 am-11:15 am
1 stop6h 55m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$119
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.
CHS-STL
GSP-STL
MYR-STL
CAE-STL
FLO-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to St. Louis
USSC-STL
CHS-STL
GSP-STL
MYR-STL
CAE-STL
What is the cheapest month to book a flight from South Carolina to St. Louis?
Currently, February is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $346). Flying from South Carolina to St. Louis in December is currently the most expensive (average of $448). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to STL?
Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 24, 2026.
One of the essential ways to save on airfare from South Carolina to St. Louis is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 21% on airfare.
How much does it cost to fly round-trip from South Carolina to St. Louis?
Airfare is below average for this route at the moment.
South Carolina to St. Louis flights typically cost between $288 and $468 in October.The cheapest round-trip price found within the last 5 days was $187 on American Airlines (Oct 27-Oct 28).
Related info for your journey
Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Wentzville
Maryland Heights
Collinsville
Edwardsville
Glencoe
Chesterfield
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
St. Louis flight routes
Top destinations
Alternative routes for South Carolina to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to St. Louis by cabin class
Find flights from South Carolina to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and St. Louis flights
Browse other South Carolina and St. Louis flight options. Last updated on September 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 24, 2026.
South Carolina to St. Louis flights
Consider these flights traveling from South Carolina to St. Louis.
Top 3 airlines flying from South Carolina to St. Louis
Discover the top 3 airlines that operate flights from South Carolina to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$226 | Average$370 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$228 | Average$391 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$253 | Average$380 | FlexibilityNo cancel fee | On-time71% |