$88+ Cheap flights from South Carolina to St. Louis (STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/3. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Sep 9 — Sep 161
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from South Carolina to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from South Carolina to St. LouisExplore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 10, 2026.
Explore the most affordable flight options available from South Carolina to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 10, 2026.
This CheapOair deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:56 am -
1 stop8h 15m
Mon 9/74:23 pm -
1 stop23h 35m
Deal found 8/5![Frontier logo]()
$186
This Trip.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:21 pm -
1 stop26h 52m
Sat 8/295:02 pm -
1 stop13h 59m
Deal found 8/6![Frontier logo]()
$195
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:44 pm -
Nonstop1h 58m
Sun 9/65:23 am -
Nonstop1h 54m
Deal found 8/7![American Airlines logo]()
$197
This CheapOair deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/109:40 pm -
1 stop19h 54m
Fri 9/185:19 pm -
1 stop14h 16m
Deal found 8/5![Frontier logo]()
$201
This Orbitz deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/108:11 pm -
1 stop24h 28m
Thu 10/158:10 pm -
1 stop21h 41m
Deal found 8/6![Frontier logo]()
$203
This Expedia deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/91:33 pm -
1 stop7h 06m
Mon 10/128:34 pm -
1 stop15h 04m
Deal found 8/5![Frontier logo]()
$205
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:30 pm -
1 stop4h 15m
Mon 9/282:45 pm -
Nonstop1h 50m
Deal found 8/9![Southwest logo]()
$208
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:30 pm -
1 stop7h 30m
Sun 9/68:40 am -
1 stop4h 38m
Deal found 8/7![United Airlines logo]()
$212
This CheapOair deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:54 pm -
1 stop24h 23m
Sun 10/45:19 pm -
1 stop14h 16m
Deal found 8/5![Frontier logo]()
$215
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:00 am -
1 stop3h 56m
Sun 9/67:00 am -
1 stop5h 10m
Deal found 8/5![Delta logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/242:13 pm -
1 stop27h 21m
Mon 9/282:29 pm -
2 stops17h 09m
Deal found 8/8![Multiple Airlines logo]()
$228
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/128:55 pm -
1 stop3h 40m
Thu 10/151:00 pm -
1 stop8h 25m
Deal found 8/9![Southwest logo]()
$236
Best flights from South Carolina to St. LouisDiscover carefully curated flight deals from South Carolina to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 10, 2026.
Discover carefully curated flight deals from South Carolina to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 10, 2026.
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:30 pm -
1 stop4h 15m
Mon 9/282:45 pm -
Nonstop1h 50m
Deal found 8/9![Southwest logo]()
$208
This CheapOair deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/129:40 pm -
1 stop19h 54m
Sat 9/198:10 pm -
1 stop21h 49m
Deal found 8/9![Frontier logo]()
$265
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:30 am -
1 stop4h 39m
Mon 10/127:00 am -
1 stop3h 35m
Deal found 8/5![Delta logo]()
$265
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:45 am -
2 stops7h 12m
Mon 9/215:30 pm -
1 stop4h 39m
Deal found 8/5![United Airlines logo]()
$270
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:43 pm -
1 stop4h 47m
Mon 9/146:53 am -
1 stop5h 25m
Deal found 8/8![American Airlines logo]()
$333
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/411:50 am -
Nonstop1h 55m
Fri 9/112:45 pm -
Nonstop1h 50m
Deal found 8/7![Southwest logo]()
$241
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/125:30 am -
1 stop4h 39m
Tue 10/1310:14 am -
1 stop4h 01m
Deal found 8/6![Delta logo]()
$265
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:50 am -
Nonstop1h 55m
Tue 9/1510:45 am -
2 stops7h 20m
Deal found 8/6![Southwest logo]()
$241
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:20 pm -
Nonstop2h 05m
Sat 9/191:40 pm -
Nonstop2h 00m
Deal found 8/6![Southwest logo]()
$255
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/22:58 pm -
1 stop8h 02m
Wed 9/98:00 am -
1 stop5h 03m
Deal found 8/6![United Airlines logo]()
$310
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:46 am -
1 stop3h 22m
Thu 8/2712:52 pm -
1 stop5h 17m
Deal found 8/6![Delta logo]()
$293
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:38 pm -
1 stop5h 22m
Sat 9/129:23 am -
2 stops8h 44m
Deal found 8/7![United Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:45 am -
2 stops7h 30m
Sat 8/2911:15 am -
1 stop6h 45m
Deal found 8/5![Southwest logo]()
$264
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3010:16 am -
1 stop3h 47m
Sun 10/45:15 am -
1 stop6h 01m
Deal found 8/9![American Airlines logo]()
$371
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/212:15 pm -
1 stop5h 02m
Wed 9/96:40 am -
2 stops7h 47m
Deal found 8/6![Delta logo]()
$315
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:15 pm -
1 stop4h 30m
Tue 9/810:45 am -
2 stops7h 20m
Deal found 8/9![Southwest logo]()
$276
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:00 pm -
1 stop16h 24m
Mon 9/76:54 am -
1 stop3h 30m
Deal found 8/9![American Airlines logo]()
$381
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:55 am -
1 stop5h 51m
Mon 9/75:23 pm -
1 stop4h 36m
Deal found 8/5![Delta logo]()
$317
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:19 am -
2 stops12h 17m
Mon 9/145:30 pm -
1 stop4h 39m
Deal found 8/7![United Airlines logo]()
$350
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:50 am -
2 stops9h 00m
Fri 9/113:45 pm -
1 stop5h 10m
Deal found 8/7![Southwest logo]()
$276
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/144:58 pm -
1 stop5h 38m
Sat 9/196:00 am -
2 stops7h 50m
Deal found 8/7![United Airlines logo]()
$350
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:40 pm -
1 stop6h 00m
Wed 9/236:53 am -
1 stop5h 28m
Deal found 8/6![American Airlines logo]()
$392
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:59 pm -
1 stop4h 59m
Mon 8/3111:00 am -
1 stop5h 32m
Deal found 8/5![Delta logo]()
$325
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/31:05 pm -
1 stop6h 20m
Thu 9/1011:40 am -
2 stops9h 15m
Deal found 8/6![Southwest logo]()
$280
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2112:59 pm -
1 stop7h 17m
Sun 8/238:50 am -
1 stop5h 14m
Deal found 8/7![United Airlines logo]()
$351
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/263:11 pm -
1 stop4h 16m
Wed 9/26:00 am -
1 stop4h 35m
Deal found 8/5![Delta logo]()
$325
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:50 am -
2 stops8h 30m
Sat 10/107:20 am -
1 stop4h 45m
Deal found 8/6![Southwest logo]()
$295
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:25 am -
1 stop6h 37m
Mon 8/318:40 am -
1 stop4h 41m
Deal found 8/6![United Airlines logo]()
$357
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/128:09 pm -
1 stop4h 45m
Thu 10/157:20 pm -
1 stop3h 37m
Deal found 8/6![Delta logo]()
$325
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/112:45 pm -
2 stops8h 41m
Mon 9/73:25 pm -
1 stop6h 51m
Deal found 8/9![American Airlines logo]()
$452
Last-minute flights from South Carolina to St. LouisDiscover last-minute flight deals from South Carolina to St. Louis. Data last updated August 10, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to St. Louis. Data last updated August 10, 2026 and is based on user searches.
This Trip.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:21 pm -
1 stop26h 52m
Sat 8/295:02 pm -
1 stop13h 59m
Deal found 8/6![Frontier logo]()
$195
This CheapOair deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:56 am -
1 stop8h 15m
Sun 8/305:02 pm -
1 stop22h 56m
Deal found 8/5![Frontier logo]()
$218
This CheapOair deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:21 pm -
1 stop26h 52m
Sat 9/55:02 pm -
1 stop13h 59m
Deal found 8/8![Frontier logo]()
$220
This CheapOair deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:56 am -
1 stop8h 15m
Mon 9/74:23 pm -
1 stop23h 35m
Deal found 8/5![Frontier logo]()
$186
This CheapOair deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/49:52 pm -
1 stop19h 19m
Mon 9/74:23 pm -
1 stop14h 38m
Deal found 8/5![Frontier logo]()
$215
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:44 pm -
Nonstop1h 58m
Sun 9/65:23 am -
Nonstop1h 54m
Deal found 8/7![American Airlines logo]()
$197
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:30 pm -
1 stop7h 30m
Sun 9/68:40 am -
1 stop4h 38m
Deal found 8/7![United Airlines logo]()
$212
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:00 am -
1 stop3h 56m
Sun 9/67:00 am -
1 stop5h 10m
Deal found 8/5![Delta logo]()
$217
This CheapOair deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/109:40 pm -
1 stop19h 54m
Fri 9/185:19 pm -
1 stop14h 16m
Deal found 8/5![Frontier logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/172:13 pm -
1 stop27h 21m
Mon 9/212:29 pm -
2 stops21h 02m
Deal found 8/9![Multiple Airlines logo]()
$236
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:30 pm -
1 stop4h 15m
Mon 9/282:45 pm -
Nonstop1h 50m
Deal found 8/9![Southwest logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/242:13 pm -
1 stop27h 21m
Mon 9/282:29 pm -
2 stops17h 09m
Deal found 8/8![Multiple Airlines logo]()
$228
One-way flights from South Carolina to St. LouisSearch for one-way flight options from South Carolina to St. Louis. Find affordable one-way fares based on user searches. Data last updated August 10, 2026.
Search for one-way flight options from South Carolina to St. Louis. Find affordable one-way fares based on user searches. Data last updated August 10, 2026.
This Frontier deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:56 am -
1 stop8h 15m
Deal found 8/6![Frontier logo]()
$88
This Expedia deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:52 pm -
1 stop19h 19m
Deal found 8/6![Frontier logo]()
$94
This CheapOair deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/99:40 pm -
1 stop21h 14m
Deal found 8/7![Frontier logo]()
$97
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:44 pm -
Nonstop1h 58m
Deal found 8/9![American Airlines logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/69:40 pm -
2 stops37h 00m
Deal found 8/7![Frontier logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/69:18 am -
2 stops49h 22m
Deal found 8/8![Multiple Airlines logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/79:40 pm -
2 stops13h 00m
Deal found 8/7![Frontier logo]()
$102
This Frontier deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/81:33 pm -
1 stop7h 06m
Deal found 8/5![Frontier logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:56 pm -
2 stops45h 26m
Deal found 8/8![Multiple Airlines logo]()
$103
This Frontier deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/101:33 pm -
1 stop7h 06m
Deal found 8/9![Frontier logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:56 pm -
2 stops21h 26m
Deal found 8/5![Multiple Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/293:00 pm -
2 stops23h 10m
Deal found 8/5![Multiple Airlines logo]()
$107
Find flight deals from South Carolina to St. Louis
Keep the following information in mind while searching for South Carolina to St. Louis flight deals. Data was last updated August 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $186 (CheapOair) |
One-way from | $88 (Frontier) |
Popular in | July |
Cheapest in | October |
Average price | $325 |
Good round-trip deal | $245 or less |
Good one-way deal | $252 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSt. Louis
CLT Charlotte Douglas - STL Lambert-St Louis
CLTSTL
Charlotte Douglas
Wed 9/23
6:30 pm-9:45 pm
1 stop4h 15m
Lambert-St Louis
Mon 9/28
2:45 pm-5:35 pm
Nonstop1h 50m
$208
Quickest round-trip
CharlotteSt. Louis
CLT Charlotte Douglas - STL Lambert-St Louis
CLTSTL
Charlotte Douglas
Fri 9/4
11:50 am-12:45 pm
Nonstop1h 55m
Lambert-St Louis
Fri 9/11
2:45 pm-5:35 pm
Nonstop1h 50m
$241
CharlotteSt. Louis
CLT Charlotte Douglas - STL Lambert-St Louis
CLTSTL
Charlotte Douglas
Fri 9/11
11:50 am-12:45 pm
Nonstop1h 55m
Lambert-St Louis
Tue 9/15
10:45 am-7:05 pm
2 stops7h 20m
$241
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Mon 9/14
5:20 pm-6:25 pm
Nonstop2h 05m
Lambert-St Louis
Sat 9/19
1:40 pm-4:40 pm
Nonstop2h 00m
$255
GreenvilleSt. Louis
GSP Greenville - STL Lambert-St Louis
GSPSTL
Greenville
Sat 8/22
6:45 am-1:15 pm
2 stops7h 30m
Lambert-St Louis
Sat 8/29
11:15 am-7:00 pm
1 stop6h 45m
$264
CharlotteSt. Louis
CLT Charlotte Douglas - STL Lambert-St Louis
CLTSTL
Charlotte Douglas
Sat 9/12
9:40 pm-4:34 pm
1 stop19h 54m
Lambert-St Louis
Sat 9/19
8:10 pm-6:59 pm
1 stop21h 49m
$265
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Thu 10/8
5:30 am-9:09 am
1 stop4h 39m
Lambert-St Louis
Mon 10/12
7:00 am-11:35 am
1 stop3h 35m
$265
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Mon 10/12
5:30 am-9:09 am
1 stop4h 39m
Lambert-St Louis
Tue 10/13
10:14 am-3:15 pm
1 stop4h 01m
$265
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Thu 9/17
5:45 am-11:57 am
2 stops7h 12m
Lambert-St Louis
Mon 9/21
5:30 pm-11:09 pm
1 stop4h 39m
$270
CharlotteSt. Louis
CLT Charlotte Douglas - STL Lambert-St Louis
CLTSTL
Charlotte Douglas
Sat 9/5
5:15 pm-8:45 pm
1 stop4h 30m
Lambert-St Louis
Tue 9/8
10:45 am-7:05 pm
2 stops7h 20m
$276
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from South Carolina with our price prediction graph.
CLT-STL
CHS-STL
FLO-STL
HHH-STL
GSP-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to St. Louis
USSC-STL
CLT-STL
CHS-STL
FLO-STL
HHH-STL
What is the cheapest month to book a flight from South Carolina to St. Louis?
Currently, September is the cheapest month in which you can book a flight from South Carolina to St. Louis (average of $325). Flying from South Carolina to St. Louis in December is currently the most expensive (average of $448). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to STL?
Find hourly flight availability from South Carolina to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 10, 2026.
One of the essential ways to save on airfare from South Carolina to St. Louis is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 11% on airfare.
How much does it cost to fly round-trip from South Carolina to St. Louis?
Airfare is below average for this route at the moment.
South Carolina to St. Louis flights typically cost between $321 and $394 in September.The cheapest round-trip price found within the last 5 days was $228 on Multiple Airlines (Sep 24-Sep 28).
Related info for your journey
Find useful and relevant information for your journey from South Carolina to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
Fairview Heights
O'Fallon
Fenton
Swansea
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Farmington
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
St. Louis flight routes
Top destinations
Alternative routes for South Carolina to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to St. Louis by cabin class
Find flights from South Carolina to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and St. Louis flights
Browse other South Carolina and St. Louis flight options. Last updated on August 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 10, 2026.
South Carolina to St. Louis flights
Consider these flights traveling from South Carolina to St. Louis.
Top 3 airlines flying from South Carolina to St. Louis
Discover the top 3 airlines that operate flights from South Carolina to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$206 | Average$364 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$228 | Average$397 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$229 | Average$392 | FlexibilityNo cancel fee | On-time71% |