$111+ Cheap flights from Charleston to St. Louis (CHS - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Jul 11 — Jul 181
Round-trip
1 adult, Economy
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Find cheap flights from Charleston to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Charleston to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Charleston to St. LouisExplore the most affordable flight options available from Charleston to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 11, 2026.
Explore the most affordable flight options available from Charleston to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 11, 2026.
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2510:45 am
CHS
- STL
1 stop6h 40m
Southwest
Tue 9/18:35 am
STL
- CHS
1 stop6h 45m
Southwest
Deal found 6/10![Southwest logo]()
$221
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:45 am
CHS
- STL
2 stops7h 17m
United Airlines
Tue 9/18:00 am
STL
- CHS
1 stop4h 58m
United Airlines
Deal found 6/10![United Airlines logo]()
$226
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:30 am
CHS
- STL
1 stop5h 06m
Delta
Mon 9/146:45 pm
STL
- CHS
1 stop4h 12m
Delta
Deal found 6/9![Delta logo]()
$265
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:35 am
CHS
- STL
1 stop4h 35m
Southwest
Thu 8/135:45 am
STL
- CHS
2 stops8h 40m
Southwest
Deal found 6/8![Southwest logo]()
$270
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:10 am
CHS
- STL
1 stop4h 09m
Delta
Wed 8/59:15 am
STL
- CHS
1 stop5h 45m
Delta
Deal found 6/10![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/27:35 pm
CHS
- STL
1 stop4h 35m
Southwest
Tue 7/73:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/10![Southwest logo]()
$287
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:44 pm
CHS
- STL
1 stop4h 34m
Delta
Tue 7/71:22 pm
STL
- CHS
1 stop4h 37m
Delta
Deal found 6/11![Delta logo]()
$292
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/253:33 pm
CHS
- STL
1 stop7h 27m
United Airlines
Wed 8/267:00 am
STL
- CHS
1 stop6h 13m
United Airlines
Deal found 6/10![United Airlines logo]()
$301
Best flights from Charleston to St. LouisDiscover carefully curated flight deals from Charleston to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 11, 2026.
Discover carefully curated flight deals from Charleston to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 11, 2026.
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:30 am
CHS
- STL
1 stop5h 06m
Delta
Mon 9/146:45 pm
STL
- CHS
1 stop4h 12m
Delta
Deal found 6/9![Delta logo]()
$265
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/27:35 pm
CHS
- STL
1 stop4h 35m
Southwest
Tue 7/73:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/10![Southwest logo]()
$287
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2511:40 am
CHS
- STL
1 stop4h 58m
United Airlines
Wed 8/267:25 am
STL
- CHS
1 stop5h 33m
United Airlines
Deal found 6/8![United Airlines logo]()
$301
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:30 am
CHS
- STL
2 stops7h 25m
Southwest
Sun 9/136:00 am
STL
- CHS
1 stop7h 35m
Southwest
Deal found 6/11![Southwest logo]()
$328
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/219:41 am
CHS
- STL
1 stop6h 07m
Delta
Fri 7/246:00 am
STL
- CHS
1 stop5h 00m
Delta
Deal found 6/7![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/2511:31 am
CHS
- STL
1 stop5h 15m
United Airlines
Tue 6/301:13 pm
STL
- CHS
1 stop7h 35m
United Airlines
Deal found 6/6![United Airlines logo]()
$337
Last-minute flights from Charleston to St. LouisDiscover last-minute flight deals from Charleston to St. Louis. Data last updated June 11, 2026 and is based on user searches.
Discover last-minute flight deals from Charleston to St. Louis. Data last updated June 11, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/303:13 pm
CHS
- STL
1 stop9h 36m
Multiple Airlines
Tue 7/76:34 pm
STL
- CHS
2 stops37h 04m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/303:13 pm
CHS
- STL
1 stop9h 36m
Multiple Airlines
Mon 7/64:57 pm
STL
- CHS
2 stops28h 50m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/303:13 pm
CHS
- STL
1 stop9h 36m
Multiple Airlines
Wed 7/84:57 pm
STL
- CHS
2 stops28h 50m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/14:04 pm
CHS
- STL
1 stop8h 45m
Multiple Airlines
Tue 7/76:34 pm
STL
- CHS
2 stops37h 04m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$324
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/14:04 pm
CHS
- STL
1 stop8h 45m
Multiple Airlines
Mon 7/64:57 pm
STL
- CHS
2 stops28h 50m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/27:35 pm
CHS
- STL
1 stop4h 35m
Southwest
Tue 7/73:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/10![Southwest logo]()
$287
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:44 pm
CHS
- STL
1 stop4h 34m
Delta
Tue 7/71:22 pm
STL
- CHS
1 stop4h 37m
Delta
Deal found 6/11![Delta logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/24:02 pm
CHS
- STL
2 stops41h 50m
Multiple Airlines
Tue 7/74:09 pm
STL
- CHS
1 stop15h 59m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$332
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:55 pm
CHS
- STL
2 stops42h 02m
Multiple Airlines
Wed 7/84:09 pm
STL
- CHS
1 stop15h 29m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:10 am
CHS
- STL
1 stop4h 09m
Delta
Wed 8/59:15 am
STL
- CHS
1 stop5h 45m
Delta
Deal found 6/10![Delta logo]()
$279
One-way flights from Charleston to St. LouisSearch for one-way flight options from Charleston to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 11, 2026.
Search for one-way flight options from Charleston to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 11, 2026.
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/41:01 pm
CHS
- STL
1 stop4h 16m
Delta
Deal found 6/10![Delta logo]()
$111
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:10 am
CHS
- STL
2 stops9h 15m
Southwest
Deal found 6/8![Southwest logo]()
$117
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/71:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Deal found 6/10![Southwest logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:27 pm
CHS
- STL
2 stops39h 30m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$130
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/69:48 am
CHS
- STL
1 stop5h 45m
Delta
Deal found 6/11![Delta logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:55 pm
CHS
- STL
2 stops42h 02m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$134
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:25 am
CHS
- STL
2 stops11h 05m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:56 pm
CHS
- STL
2 stops21h 34m
Multiple Airlines
Deal found 6/10![Multiple Airlines logo]()
$142
Find flight deals from Charleston to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Charleston (CHS) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $221 (Southwest) |
One-way from | $111 (Delta) |
Popular in | November |
Cheapest in | February |
Average price | $374 |
Good round-trip deal | $330 or less |
Good one-way deal | $219 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Charleston to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 11, 2026.
Use the filters below to find and compare flights from Charleston to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Thu 9/10
5:30 am-9:36 am
1 stop5h 06m
Lambert-St Louis
Mon 9/14
6:45 pm-11:57 pm
1 stop4h 12m
$265
Quickest round-trip
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Thu 7/2
7:35 pm-11:10 pm
1 stop4h 35m
Lambert-St Louis
Tue 7/7
3:15 pm-6:15 pm
Nonstop2h 00m
$287
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Tue 8/25
11:40 am-3:38 pm
1 stop4h 58m
Lambert-St Louis
Wed 8/26
7:25 am-1:58 pm
1 stop5h 33m
$301
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Fri 9/11
11:30 am-5:55 pm
2 stops7h 25m
Lambert-St Louis
Sun 9/13
6:00 am-2:35 pm
1 stop7h 35m
$328
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Tue 7/21
9:41 am-2:48 pm
1 stop6h 07m
Lambert-St Louis
Fri 7/24
6:00 am-12:00 pm
1 stop5h 00m
$337
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Thu 6/25
11:31 am-3:46 pm
1 stop5h 15m
Lambert-St Louis
Tue 6/30
1:13 pm-9:48 pm
1 stop7h 35m
$337
Cheapest one-way
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Tue 12/8
5:30 am-10:48 am
1 stop6h 18m
$111
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Tue 7/7
6:00 am-12:11 pm
1 stop7h 11m
$124
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Wed 7/8
6:28 pm-11:53 pm
1 stop6h 25m
$124
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Tue 7/7
3:00 pm-11:05 pm
2 stops9h 05m
$129
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Charleston to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Charleston to St. Louis in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Charleston-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Charleston-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Charleston-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Charleston-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Charleston-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Charleston to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Charleston with our price prediction graph.
CHS-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Charleston to St. Louis
What is the cheapest month to book a flight from Charleston to St. Louis?
Currently, February is the cheapest month in which you can book a flight from Charleston to St. Louis (average of $276). Flying from Charleston to St. Louis in November is currently the most expensive (average of $495). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from CHS to STL?
Find hourly flight availability from Charleston to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 11, 2026.
A simple way to save on the total cost of your ticket is to fly from Charleston to St. Louis in the morning. If you’re flexible enough to do this you can expect to save up to 32% on your trip compared to booking a flight at noon.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated June 11, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Charleston to St. Louis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Overall
7.9
Food
7.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Overall
7.9
Food
7.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Overall
7.9
Food
7.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Overall
7.9
Food
7.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Charleston to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Browse thousands of different options on Cheapflights for your next trip
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Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
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Charleston and St. Louis flights
Browse other Charleston and St. Louis flight options. Last updated on June 11, 2026.
Other flights from Charleston
Browse through other flights departing from Charleston. Flights are based on user searches made on Cheapflights and were last updated on June 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 11, 2026.
Top 3 airlines flying from Charleston to St. Louis
Discover the top 3 airlines that operate flights from Charleston to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$206 | Average$351 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$274 | Average$352 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$281 | Average$373 | FlexibilityNo cancel fee | On-time63% |