$105+ Cheap flights from South Carolina to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/5. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — MCI
Jul 11 — Jul 181
Round-trip
1 adult, Economy
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Cheapest flights from South Carolina to MissouriExplore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 11, 2026.
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 11, 2026.
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/59:45 pm
CLT
- STL
Nonstop1h 55m
American Airlines
Wed 8/126:54 am
STL
- CLT
Nonstop1h 55m
American Airlines
Deal found 6/10![American Airlines logo]()
$189
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/47:37 am
CLT
- STL
Nonstop1h 56m
American Airlines
Sat 8/86:54 am
STL
- CLT
Nonstop1h 55m
American Airlines
Deal found 6/8![American Airlines logo]()
$193
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:10 am
CLT
- STL
1 stop4h 36m
Delta
Wed 8/1212:52 pm
STL
- CLT
1 stop4h 50m
Delta
Deal found 6/8![Delta logo]()
$209
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:50 am
CLT
- STL
2 stops9h 00m
Southwest
Tue 8/116:30 am
STL
- CLT
1 stop4h 25m
Southwest
Deal found 6/10![Southwest logo]()
$214
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/711:45 am
CLT
- STL
2 stops8h 50m
Southwest
Wed 10/1411:50 am
STL
- CLT
1 stop7h 35m
Southwest
Deal found 6/8![Southwest logo]()
$215
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:35 am
CLT
- STL
Nonstop1h 57m
American Airlines
Sat 7/47:32 am
STL
- CLT
Nonstop1h 58m
American Airlines
Deal found 6/10![American Airlines logo]()
$217
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:50 am
CLT
- STL
2 stops9h 00m
Southwest
Wed 8/2610:15 am
STL
- CLT
2 stops9h 55m
Southwest
Deal found 6/10![Southwest logo]()
$220
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2510:45 am
CHS
- STL
1 stop6h 40m
Southwest
Tue 9/18:35 am
STL
- CHS
1 stop6h 45m
Southwest
Deal found 6/10![Southwest logo]()
$221
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1711:50 am
CLT
- STL
Nonstop1h 55m
Southwest
Wed 10/218:35 am
STL
- CLT
1 stop5h 00m
Southwest
Deal found 6/8![Southwest logo]()
$222
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:05 pm
SAV
- STL
1 stop5h 05m
Southwest
Tue 9/810:45 am
STL
- SAV
1 stop5h 55m
Southwest
Deal found 6/7![Southwest logo]()
$225
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:45 am
CHS
- STL
2 stops7h 17m
United Airlines
Tue 9/18:00 am
STL
- CHS
1 stop4h 58m
United Airlines
Deal found 6/10![United Airlines logo]()
$226
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Sat 7/411:10 am
STL
- CLT
1 stop6h 15m
Southwest
Deal found 6/10![Southwest logo]()
$227
Best flights from South Carolina to MissouriDiscover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 11, 2026.
Discover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 11, 2026.
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Sat 7/410:15 am
STL
- CLT
2 stops7h 05m
Southwest
Deal found 6/10![Southwest logo]()
$232
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:30 am
CHS
- STL
1 stop5h 06m
Delta
Mon 9/146:45 pm
STL
- CHS
1 stop4h 12m
Delta
Deal found 6/9![Delta logo]()
$265
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2511:40 am
CHS
- STL
1 stop4h 58m
United Airlines
Wed 8/267:25 am
STL
- CHS
1 stop5h 33m
United Airlines
Deal found 6/8![United Airlines logo]()
$301
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/179:40 pm
MYR
- STL
2 stops36h 12m
Multiple Airlines
Mon 8/244:10 pm
STL
- MYR
1 stop16h 55m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:51 am
MYR
- MCI
1 stop5h 32m
American Airlines
Sun 7/266:00 am
MCI
- MYR
2 stops8h 31m
American Airlines
Deal found 6/7![American Airlines logo]()
$408
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:15 pm
CLT
- STL
1 stop4h 25m
Southwest
Mon 8/172:45 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 6/10![Southwest logo]()
$242
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:35 am
SAV
- STL
1 stop4h 19m
Delta
Mon 8/106:00 am
STL
- SAV
1 stop4h 40m
Delta
Deal found 6/11![Delta logo]()
$267
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/254:59 pm
SAV
- STL
1 stop6h 01m
United Airlines
Wed 8/267:25 am
STL
- SAV
1 stop6h 39m
United Airlines
Deal found 6/8![United Airlines logo]()
$305
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:40 pm
CLT
- STL
Nonstop2h 10m
Southwest
Tue 7/73:10 pm
STL
- CLT
1 stop6h 00m
Southwest
Deal found 6/11![Southwest logo]()
$283
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:59 pm
MYR
- STL
1 stop4h 54m
Delta
Tue 7/216:58 pm
STL
- MYR
1 stop3h 57m
Delta
Deal found 6/8![Delta logo]()
$297
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/207:05 pm
CLT
- STL
1 stop4h 50m
Southwest
Wed 7/224:50 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 6/9![Southwest logo]()
$283
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:39 am
SAV
- STL
1 stop5h 07m
Delta
Tue 7/71:22 pm
STL
- SAV
1 stop6h 55m
Delta
Deal found 6/9![Delta logo]()
$297
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/2511:31 am
CHS
- STL
1 stop5h 15m
United Airlines
Tue 6/301:13 pm
STL
- CHS
1 stop7h 35m
United Airlines
Deal found 6/6![United Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:40 am
CLT
- STL
2 stops8h 40m
Southwest
Sun 8/303:05 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 6/10![Southwest logo]()
$284
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/27:35 pm
CHS
- STL
1 stop4h 35m
Southwest
Tue 7/73:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/10![Southwest logo]()
$287
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/14:33 pm
GSP
- MCI
1 stop7h 57m
United Airlines
Wed 9/26:00 am
MCI
- GSP
2 stops7h 19m
United Airlines
Deal found 6/8![United Airlines logo]()
$350
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/177:59 pm
MYR
- STL
1 stop4h 54m
Delta
Mon 7/209:24 am
STL
- MYR
1 stop5h 15m
Delta
Deal found 6/7![Delta logo]()
$337
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:37 pm
CLT
- SGF
Nonstop2h 33m
American Airlines
Tue 11/177:07 am
SGF
- CLT
Nonstop2h 18m
American Airlines
Deal found 6/8![American Airlines logo]()
$455
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1411:50 am
CLT
- STL
Nonstop1h 55m
Southwest
Sun 8/163:05 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 6/8![Southwest logo]()
$290
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/235:39 am
SAV
- STL
1 stop3h 40m
Delta
Mon 7/277:08 am
STL
- SAV
1 stop6h 30m
Delta
Deal found 6/10![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:30 am
CLT
- STL
2 stops7h 45m
Southwest
Sat 8/159:00 am
STL
- CLT
1 stop6h 35m
Southwest
Deal found 6/6![Southwest logo]()
$290
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:28 pm
CLT
- SGF
Nonstop2h 22m
American Airlines
Sun 7/126:53 am
SGF
- CLT
Nonstop2h 22m
American Airlines
Deal found 6/11![American Airlines logo]()
$490
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/219:41 am
CHS
- STL
1 stop6h 07m
Delta
Fri 7/246:00 am
STL
- CHS
1 stop5h 00m
Delta
Deal found 6/7![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/293:24 pm
MYR
- MCI
1 stop5h 18m
United Airlines
Tue 9/17:30 am
MCI
- MYR
1 stop6h 23m
United Airlines
Deal found 6/11![United Airlines logo]()
$417
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/97:10 am
CLT
- STL
2 stops12h 20m
Southwest
Tue 7/145:40 am
STL
- CLT
2 stops7h 55m
Southwest
Deal found 6/9![Southwest logo]()
$296
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/77:50 am
SAV
- STL
1 stop4h 40m
Southwest
Tue 7/141:20 pm
STL
- SAV
1 stop6h 20m
Southwest
Deal found 6/7![Southwest logo]()
$297
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/212:05 pm
SAV
- MCI
1 stop7h 58m
United Airlines
Sun 7/56:05 am
MCI
- SAV
1 stop7h 09m
United Airlines
Deal found 6/7![United Airlines logo]()
$440
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:40 am
GSP
- MCI
1 stop6h 29m
Delta
Sun 11/15:26 pm
MCI
- GSP
1 stop5h 11m
Delta
Deal found 6/11![Delta logo]()
$376
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:00 pm
MYR
- STL
Nonstop2h 05m
Southwest
Tue 7/71:45 pm
STL
- MYR
1 stop5h 50m
Southwest
Deal found 6/10![Southwest logo]()
$307
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:00 am
CHS
- MCI
1 stop7h 22m
United Airlines
Wed 7/293:16 pm
MCI
- CHS
1 stop5h 32m
United Airlines
Deal found 6/8![United Airlines logo]()
$459
Last-minute flights from South Carolina to MissouriDiscover last-minute flight deals from South Carolina to Missouri. Data last updated June 11, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Missouri. Data last updated June 11, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:35 am
CLT
- STL
Nonstop1h 57m
American Airlines
Tue 7/76:13 pm
STL
- CLT
Nonstop1h 58m
American Airlines
Deal found 6/10![American Airlines logo]()
$217
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Sat 7/411:10 am
STL
- CLT
1 stop6h 15m
Southwest
Deal found 6/10![Southwest logo]()
$227
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/18:15 pm
CLT
- STL
1 stop3h 45m
Southwest
Tue 7/73:10 pm
STL
- CLT
1 stop6h 00m
Southwest
Deal found 6/10![Southwest logo]()
$237
This Mytrip deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/112:29 pm
CLT
- STL
1 stop12h 20m
Frontier
Mon 7/64:09 pm
STL
- CLT
1 stop23h 29m
Frontier
Deal found 6/9![Frontier logo]()
$258
This Mytrip deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/412:29 pm
CLT
- STL
1 stop12h 20m
Frontier
Wed 7/84:09 pm
STL
- CLT
1 stop23h 49m
Frontier
Deal found 6/8![Frontier logo]()
$253
This CheapOair deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/412:29 pm
CLT
- STL
1 stop12h 20m
Frontier
Tue 7/74:09 pm
STL
- CLT
1 stop23h 49m
Frontier
Deal found 6/8![Frontier logo]()
$254
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/116:00 am
CLT
- STL
2 stops7h 11m
United Airlines
Sat 7/187:20 am
STL
- CLT
1 stop5h 30m
United Airlines
Deal found 6/11![United Airlines logo]()
$255
This Frontier deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1110:14 pm
CLT
- MCI
1 stop15h 46m
Frontier
Mon 7/131:45 pm
MCI
- CLT
1 stop6h 34m
Frontier
Deal found 6/9![Frontier logo]()
$264
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Tue 7/213:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/11![Southwest logo]()
$237
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:05 am
CLT
- STL
1 stop5h 06m
United Airlines
Sat 7/251:18 pm
STL
- CLT
1 stop7h 11m
United Airlines
Deal found 6/10![United Airlines logo]()
$245
This CheapOair deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2710:59 pm
CLT
- STL
1 stop26h 00m
Frontier
Wed 7/294:09 pm
STL
- CLT
1 stop18h 20m
Frontier
Deal found 6/10![Frontier logo]()
$259
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/314:40 pm
CLT
- STL
Nonstop2h 10m
Southwest
Tue 8/43:45 pm
STL
- CLT
1 stop4h 25m
Southwest
Deal found 6/7![Southwest logo]()
$256
One-way flights from South Carolina to MissouriSearch for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated June 11, 2026.
Search for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated June 11, 2026.
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/512:35 pm
CLT
- STL
1 stop6h 20m
Southwest
Deal found 6/8![Southwest logo]()
$105
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/9![Southwest logo]()
$109
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:30 am
CLT
- STL
1 stop5h 24m
Delta
Deal found 6/8![Delta logo]()
$111
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/45:10 am
CHS
- STL
1 stop5h 44m
Delta
Deal found 6/8![Delta logo]()
$111
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/510:50 am
SAV
- STL
1 stop8h 05m
Southwest
Deal found 6/8![Southwest logo]()
$113
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/412:35 pm
CLT
- MCI
1 stop6h 00m
Southwest
Deal found 6/7![Southwest logo]()
$115
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:10 am
CHS
- STL
2 stops9h 15m
Southwest
Deal found 6/8![Southwest logo]()
$117
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/611:50 am
CLT
- STL
Nonstop1h 55m
Southwest
Deal found 6/9![Southwest logo]()
$118
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:39 pm
CLT
- STL
1 stop5h 36m
Delta
Deal found 6/8![Delta logo]()
$119
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/71:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Deal found 6/9![Southwest logo]()
$119
This Frontier deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3012:29 pm
CLT
- STL
1 stop12h 20m
Frontier
Deal found 6/6![Frontier logo]()
$121
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:00 am
MYR
- MCI
1 stop4h 19m
Delta
Deal found 6/10![Delta logo]()
$121
Find flight deals from South Carolina to Missouri
Keep the following information in mind while searching for South Carolina to Missouri flight deals. Data was last updated June 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $189 (American Airlines) |
One-way from | $105 (Southwest) |
Popular in | December |
Cheapest in | August |
Average price | $379 |
Good round-trip deal | $330 or less |
Good one-way deal | $203 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 11, 2026.
Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 7/1
1:25 pm-2:25 pm
Nonstop2h 00m
Lambert-St Louis
Sat 7/4
10:15 am-6:20 pm
2 stops7h 05m
$232
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Sat 8/15
5:15 pm-8:40 pm
1 stop4h 25m
Lambert-St Louis
Mon 8/17
2:45 pm-5:35 pm
Nonstop1h 50m
$242
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Thu 9/10
5:30 am-9:36 am
1 stop5h 06m
Lambert-St Louis
Mon 9/14
6:45 pm-11:57 pm
1 stop4h 12m
$265
SavannahSt. Louis
SAV - STL
SAVSTL
Savannah/Hilton Head
Thu 8/6
6:35 am-9:54 am
1 stop4h 19m
Lambert-St Louis
Mon 8/10
6:00 am-11:40 am
1 stop4h 40m
$267
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Fri 7/3
4:40 pm-5:50 pm
Nonstop2h 10m
Lambert-St Louis
Tue 7/7
3:10 pm-10:10 pm
1 stop6h 00m
$283
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Mon 7/20
7:05 pm-10:55 pm
1 stop4h 50m
Lambert-St Louis
Wed 7/22
4:50 pm-7:40 pm
Nonstop1h 50m
$283
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Thu 8/27
7:40 am-3:20 pm
2 stops8h 40m
Lambert-St Louis
Sun 8/30
3:05 pm-5:55 pm
Nonstop1h 50m
$284
CharlestonSt. Louis
CHS - STL
CHSSTL
Charleston
Thu 7/2
7:35 pm-11:10 pm
1 stop4h 35m
Lambert-St Louis
Tue 7/7
3:15 pm-6:15 pm
Nonstop2h 00m
$287
Quickest round-trip
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Fri 8/14
11:50 am-12:45 pm
Nonstop1h 55m
Lambert-St Louis
Sun 8/16
3:05 pm-5:55 pm
Nonstop1h 50m
$290
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Sat 8/8
6:30 am-1:15 pm
2 stops7h 45m
Lambert-St Louis
Sat 8/15
9:00 am-4:35 pm
1 stop6h 35m
$290
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.
CLT-STL
CHS-STL
MYR-STL
MYR-MCI
SAV-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Missouri
USSC-USMO
CLT-STL
CHS-STL
MYR-STL
MYR-MCI
What is the cheapest month to book a flight from South Carolina to Missouri?
Currently, October is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $158). Flying from South Carolina to Missouri in March is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to MO?
Find hourly flight availability from South Carolina to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 11, 2026.
It’s optimal to fly from South Carolina to Missouri in the afternoon. By choosing this option you can save up to 26% on the cost of your flight, compared to a flight at noon.
How much does it cost to fly round-trip from South Carolina to Missouri?
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated June 11, 2026.
Read through reviews of airlines operating flights from South Carolina to Missouri, such as Southwest,Delta, andUnited Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.5
Overall
7.9
Food
7.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Entertainment
7.5
Overall
7.9
Food
7.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Entertainment
7.5
Overall
7.9
Food
7.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Entertainment
7.5
Overall
7.9
Food
7.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Comfort
8.0
Entertainment
7.5
Overall
7.9
Food
7.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
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Top destinations
Alternative routes for South Carolina to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Missouri by cabin class
Find flights from South Carolina to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Missouri flights
Browse other South Carolina and Missouri flight options. Last updated on June 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to South Carolina after your stay in Missouri
South Carolina to Missouri flights
Consider these flights traveling from South Carolina to Missouri.
Top 4 airlines flying from South Carolina to Missouri
Discover the top 4 airlines that operate flights from South Carolina to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$177 | Average$406 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$206 | Average$408 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$403 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$281 | Average$413 | FlexibilityNo cancel fee | On-time63% |