$99+ Cheap flights from South Carolina to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/8. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — MCI
Jul 18 — Jul 251
Round-trip
1 adult, Economy
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Cheapest flights from South Carolina to MissouriExplore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 18, 2026.
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 18, 2026.
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:37 am
CLT
- STL
Nonstop1h 56m
American Airlines
Wed 7/156:13 pm
STL
- CLT
Nonstop1h 58m
American Airlines
Deal found 6/17![American Airlines logo]()
$197
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Wed 7/1510:15 am
STL
- CLT
1 stop6h 35m
Southwest
Deal found 6/15![Southwest logo]()
$207
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/211:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Tue 7/289:40 am
STL
- CLT
2 stops7h 10m
Southwest
Deal found 6/17![Southwest logo]()
$212
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/511:50 am
CLT
- STL
1 stop5h 27m
Delta
Wed 8/1211:00 am
STL
- CLT
1 stop4h 12m
Delta
Deal found 6/16![Delta logo]()
$217
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Tue 7/213:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/15![Southwest logo]()
$217
This CheapOair deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:14 pm
CLT
- MCI
1 stop18h 46m
Frontier
Wed 9/21:45 pm
MCI
- CLT
1 stop6h 39m
Frontier
Deal found 6/14![Frontier logo]()
$220
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:10 am
CHS
- STL
1 stop4h 09m
Delta
Tue 7/287:08 am
STL
- CHS
1 stop5h 34m
Delta
Deal found 6/17![Delta logo]()
$227
This CheapOair deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2910:04 pm
CLT
- MCI
1 stop15h 56m
Frontier
Wed 8/51:45 pm
MCI
- CLT
1 stop6h 34m
Frontier
Deal found 6/15![Frontier logo]()
$230
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/59:45 pm
CLT
- STL
Nonstop1h 55m
American Airlines
Sat 8/85:00 am
STL
- CLT
1 stop4h 36m
American Airlines
Deal found 6/17![American Airlines logo]()
$231
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:50 am
CLT
- STL
2 stops11h 35m
Southwest
Tue 7/145:40 am
STL
- CLT
2 stops7h 55m
Southwest
Deal found 6/14![Southwest logo]()
$233
This CheapOair deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/512:24 pm
CLT
- STL
1 stop12h 35m
Frontier
Mon 8/104:09 pm
STL
- CLT
1 stop18h 20m
Frontier
Deal found 6/16![Frontier logo]()
$235
This CheapOair deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:14 pm
CLT
- STL
1 stop25h 09m
Frontier
Fri 8/218:08 pm
STL
- CLT
1 stop24h 16m
Frontier
Deal found 6/16![Frontier logo]()
$236
Best flights from South Carolina to MissouriDiscover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 18, 2026.
Discover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 18, 2026.
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/151:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Tue 7/218:25 am
STL
- CLT
2 stops8h 25m
Southwest
Deal found 6/17![Southwest logo]()
$212
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:30 am
CLT
- STL
1 stop3h 49m
Delta
Tue 7/213:58 pm
STL
- CLT
1 stop7h 00m
Delta
Deal found 6/16![Delta logo]()
$217
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:51 am
MYR
- STL
1 stop6h 09m
American Airlines
Wed 7/229:25 am
STL
- MYR
1 stop5h 06m
American Airlines
Deal found 6/13![American Airlines logo]()
$297
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:00 am
CHS
- STL
1 stop5h 17m
United Airlines
Wed 8/268:00 am
STL
- CHS
1 stop4h 58m
United Airlines
Deal found 6/17![United Airlines logo]()
$307
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:59 am
CLT
- STL
1 stop3h 44m
Delta
Wed 7/159:24 am
STL
- CLT
1 stop5h 53m
Delta
Deal found 6/17![Delta logo]()
$217
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:40 pm
GSP
- STL
1 stop4h 25m
Southwest
Wed 7/1510:15 am
STL
- GSP
2 stops9h 05m
Southwest
Deal found 6/15![Southwest logo]()
$254
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:30 am
CLT
- STL
1 stop5h 24m
Delta
Mon 8/109:15 am
STL
- CLT
1 stop5h 57m
Delta
Deal found 6/13![Delta logo]()
$241
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:50 am
CLT
- STL
2 stops9h 00m
Southwest
Sat 8/88:30 am
STL
- CLT
2 stops9h 50m
Southwest
Deal found 6/17![Southwest logo]()
$257
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/116:00 am
CLT
- STL
1 stop4h 06m
Delta
Fri 7/176:00 am
STL
- CLT
1 stop6h 31m
Delta
Deal found 6/17![Delta logo]()
$270
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/412:55 pm
CLT
- STL
2 stops7h 25m
Southwest
Wed 7/810:15 am
STL
- CLT
1 stop6h 35m
Southwest
Deal found 6/16![Southwest logo]()
$271
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:43 pm
GSP
- STL
1 stop5h 17m
United Airlines
Wed 8/269:30 am
STL
- GSP
1 stop6h 32m
United Airlines
Deal found 6/17![United Airlines logo]()
$329
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2711:50 am
CLT
- STL
Nonstop1h 55m
Southwest
Sun 8/303:05 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 6/15![Southwest logo]()
$274
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/258:44 pm
MYR
- STL
1 stop4h 14m
American Airlines
Sun 7/266:14 am
STL
- MYR
1 stop5h 57m
American Airlines
Deal found 6/17![American Airlines logo]()
$372
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:15 am
CHS
- STL
1 stop4h 39m
Delta
Fri 8/285:23 pm
STL
- CHS
1 stop5h 36m
Delta
Deal found 6/13![Delta logo]()
$287
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/181:55 pm
GSP
- STL
1 stop9h 10m
Southwest
Tue 7/213:10 pm
STL
- GSP
1 stop5h 55m
Southwest
Deal found 6/15![Southwest logo]()
$278
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/22:47 pm
CHS
- STL
2 stops9h 57m
United Airlines
Tue 7/71:13 pm
STL
- CHS
1 stop7h 35m
United Airlines
Deal found 6/15![United Airlines logo]()
$372
This American Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/174:43 pm
MYR
- STL
1 stop8h 21m
American Airlines
Mon 7/2012:35 pm
STL
- MYR
1 stop6h 28m
American Airlines
Deal found 6/18![American Airlines logo]()
$373
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2011:50 am
CLT
- STL
Nonstop1h 55m
Southwest
Sun 8/2311:20 am
STL
- CLT
1 stop3h 50m
Southwest
Deal found 6/13![Southwest logo]()
$284
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:59 pm
MYR
- STL
1 stop5h 39m
United Airlines
Wed 8/127:25 am
STL
- MYR
1 stop6h 28m
United Airlines
Deal found 6/13![United Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:10 pm
MYR
- STL
2 stops7h 06m
American Airlines
Thu 7/97:32 am
STL
- MYR
1 stop6h 59m
American Airlines
Deal found 6/15![American Airlines logo]()
$393
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/115:31 pm
SAV
- STL
1 stop4h 06m
Delta
Mon 7/136:58 pm
STL
- SAV
1 stop3h 55m
Delta
Deal found 6/13![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/273:35 pm
SAV
- MCI
1 stop8h 00m
United Airlines
Mon 8/311:02 pm
MCI
- SAV
1 stop7h 17m
United Airlines
Deal found 6/17![United Airlines logo]()
$379
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/24:40 pm
CLT
- STL
Nonstop2h 10m
Southwest
Tue 7/75:40 am
STL
- CLT
1 stop4h 30m
Southwest
Deal found 6/13![Southwest logo]()
$293
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:07 pm
SAV
- STL
1 stop5h 46m
Delta
Mon 7/273:58 pm
STL
- SAV
1 stop5h 51m
Delta
Deal found 6/14![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/93:15 pm
MYR
- STL
1 stop7h 11m
United Airlines
Tue 7/146:00 am
STL
- MYR
1 stop7h 19m
United Airlines
Deal found 6/17![United Airlines logo]()
$387
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/35:56 pm
SAV
- MCI
1 stop6h 02m
American Airlines
Thu 8/65:00 am
MCI
- SAV
2 stops7h 31m
American Airlines
Deal found 6/13![American Airlines logo]()
$432
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/31:05 pm
GSP
- STL
2 stops7h 50m
Southwest
Mon 9/76:05 am
STL
- GSP
1 stop9h 00m
Southwest
Deal found 6/14![Southwest logo]()
$300
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:15 am
CHS
- STL
1 stop4h 28m
Delta
Thu 7/166:58 pm
STL
- CHS
1 stop4h 28m
Delta
Deal found 6/15![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:30 am
GSP
- MCI
1 stop6h 50m
United Airlines
Wed 8/267:30 am
MCI
- GSP
1 stop5h 02m
United Airlines
Deal found 6/15![United Airlines logo]()
$397
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:50 am
SAV
- STL
1 stop6h 35m
Southwest
Wed 9/2310:45 am
STL
- SAV
2 stops7h 50m
Southwest
Deal found 6/17![Southwest logo]()
$304
Last-minute flights from South Carolina to MissouriDiscover last-minute flight deals from South Carolina to Missouri. Data last updated June 18, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Missouri. Data last updated June 18, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:37 am
CLT
- STL
Nonstop1h 56m
American Airlines
Wed 7/156:13 pm
STL
- CLT
Nonstop1h 58m
American Airlines
Deal found 6/17![American Airlines logo]()
$197
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Wed 7/1510:15 am
STL
- CLT
1 stop6h 35m
Southwest
Deal found 6/15![Southwest logo]()
$207
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:59 am
CLT
- STL
1 stop3h 44m
Delta
Wed 7/159:24 am
STL
- CLT
1 stop5h 53m
Delta
Deal found 6/16![Delta logo]()
$217
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:50 am
CLT
- STL
2 stops11h 35m
Southwest
Tue 7/145:40 am
STL
- CLT
2 stops7h 55m
Southwest
Deal found 6/14![Southwest logo]()
$233
This CheapOair deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/812:24 pm
CLT
- STL
1 stop12h 35m
Frontier
Wed 7/154:09 pm
STL
- CLT
1 stop23h 49m
Frontier
Deal found 6/15![Frontier logo]()
$240
This CheapOair deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/810:04 pm
CLT
- MCI
1 stop15h 56m
Frontier
Wed 7/221:45 pm
MCI
- CLT
1 stop6h 34m
Frontier
Deal found 6/16![Frontier logo]()
$240
This CheapOair deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/1210:59 pm
CLT
- STL
1 stop26h 00m
Frontier
Tue 7/144:09 pm
STL
- CLT
1 stop23h 49m
Frontier
Deal found 6/17![Frontier logo]()
$247
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Tue 7/213:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/15![Southwest logo]()
$217
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:10 am
CHS
- STL
1 stop4h 09m
Delta
Tue 7/287:08 am
STL
- CHS
1 stop5h 34m
Delta
Deal found 6/17![Delta logo]()
$227
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/211:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Tue 7/289:40 am
STL
- CLT
2 stops7h 10m
Southwest
Deal found 6/17![Southwest logo]()
$212
This CheapOair deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2112:24 pm
CLT
- STL
1 stop12h 35m
Frontier
Fri 7/244:09 pm
STL
- CLT
1 stop18h 20m
Frontier
Deal found 6/16![Frontier logo]()
$246
This CheapOair deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2910:04 pm
CLT
- MCI
1 stop15h 56m
Frontier
Wed 8/51:45 pm
MCI
- CLT
1 stop6h 34m
Frontier
Deal found 6/15![Frontier logo]()
$230
One-way flights from South Carolina to MissouriSearch for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated June 18, 2026.
Search for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated June 18, 2026.
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/17![Southwest logo]()
$99
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/119:33 am
CLT
- STL
1 stop6h 00m
Delta
Deal found 6/16![Delta logo]()
$109
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Deal found 6/16![Southwest logo]()
$109
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:50 am
CLT
- STL
2 stops9h 00m
Southwest
Deal found 6/17![Southwest logo]()
$114
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:00 pm
CHS
- STL
1 stop6h 15m
Delta
Deal found 6/16![Delta logo]()
$114
This CheapOair deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1210:04 pm
CLT
- MCI
1 stop15h 56m
Frontier
Deal found 6/15![Frontier logo]()
$116
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:50 am
CLT
- STL
2 stops11h 35m
Southwest
Deal found 6/17![Southwest logo]()
$120
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1311:50 am
CLT
- STL
Nonstop1h 55m
Southwest
Deal found 6/16![Southwest logo]()
$123
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:20 pm
CHS
- STL
Nonstop2h 05m
Southwest
Deal found 6/16![Southwest logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:43 pm
CHS
- MCI
2 stops23h 27m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:43 pm
CHS
- STL
2 stops39h 14m
Multiple Airlines
Deal found 6/13![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/159:18 am
CHS
- MCI
2 stops32h 58m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$125
Find flight deals from South Carolina to Missouri
Keep the following information in mind while searching for South Carolina to Missouri flight deals. Data was last updated June 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $197 (American Airlines) |
One-way from | $99 (Southwest) |
Popular in | December |
Cheapest in | August |
Average price | $350 |
Good round-trip deal | $336 or less |
Good one-way deal | $203 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 18, 2026.
Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 7/15
1:25 pm-2:25 pm
Nonstop2h 00m
Lambert-St Louis
Tue 7/21
8:25 am-5:50 pm
2 stops8h 25m
$212
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Tue 7/14
5:30 am-8:19 am
1 stop3h 49m
Lambert-St Louis
Tue 7/21
3:58 pm-11:58 pm
1 stop7h 00m
$217
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 7/8
6:59 am-9:43 am
1 stop3h 44m
Lambert-St Louis
Wed 7/15
9:24 am-4:17 pm
1 stop5h 53m
$217
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 8/5
5:30 am-9:54 am
1 stop5h 24m
Lambert-St Louis
Mon 8/10
9:15 am-4:12 pm
1 stop5h 57m
$241
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Tue 7/14
7:40 pm-11:05 pm
1 stop4h 25m
Lambert-St Louis
Wed 7/15
10:15 am-8:20 pm
2 stops9h 05m
$254
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Wed 8/5
6:50 am-2:50 pm
2 stops9h 00m
Lambert-St Louis
Sat 8/8
8:30 am-7:20 pm
2 stops9h 50m
$257
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Sat 7/11
6:00 am-9:06 am
1 stop4h 06m
Lambert-St Louis
Fri 7/17
6:00 am-1:31 pm
1 stop6h 31m
$270
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Sat 7/4
12:55 pm-7:20 pm
2 stops7h 25m
Lambert-St Louis
Wed 7/8
10:15 am-5:50 pm
1 stop6h 35m
$271
Quickest round-trip
CharlotteSt. Louis
CLT - STL
CLTSTL
Charlotte Douglas
Thu 8/27
11:50 am-12:45 pm
Nonstop1h 55m
Lambert-St Louis
Sun 8/30
3:05 pm-5:55 pm
Nonstop1h 50m
$274
GreenvilleSt. Louis
GSP - STL
GSPSTL
Greenville
Sat 7/18
1:55 pm-10:05 pm
1 stop9h 10m
Lambert-St Louis
Tue 7/21
3:10 pm-10:05 pm
1 stop5h 55m
$278
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.
CLT-STL
CHS-STL
CLT-MCI
MYR-STL
GSP-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Missouri
USSC-USMO
CLT-STL
CHS-STL
CLT-MCI
MYR-STL
What is the cheapest month to book a flight from South Carolina to Missouri?
Currently, September is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $154). Flying from South Carolina to Missouri in March is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to MO?
Find hourly flight availability from South Carolina to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 18, 2026.
It’s optimal to fly from South Carolina to Missouri in the afternoon. By choosing this option you can save up to 46% on the cost of your flight, compared to a flight in the evening.
How much does it cost to fly round-trip from South Carolina to Missouri?
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated June 18, 2026.
Read through reviews of airlines operating flights from South Carolina to Missouri, such as Southwest,Delta, andUnited Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Overall
7.9
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Crew
8.6
Overall
7.9
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Crew
8.6
Overall
7.9
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Crew
8.6
Overall
7.9
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Crew
8.6
Overall
7.9
Entertainment
7.5
Food
7.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for South Carolina to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Missouri by cabin class
Find flights from South Carolina to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Missouri flights
Browse other South Carolina and Missouri flight options. Last updated on June 18, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to South Carolina after your stay in Missouri
South Carolina to Missouri flights
Consider these flights traveling from South Carolina to Missouri.
Top 4 airlines flying from South Carolina to Missouri
Discover the top 4 airlines that operate flights from South Carolina to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$177 | Average$413 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$206 | Average$408 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$403 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$281 | Average$410 | FlexibilityNo cancel fee | On-time63% |