$80+ Cheap flights from South Carolina to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/3. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Sep 16 — Sep 231
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Missouri with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from South Carolina to MissouriExplore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 17, 2026.
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 17, 2026.
This CheapOair deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/109:32 am -
1 stop9h 22m
Mon 9/145:19 pm -
1 stop20h 57m
Deal found 8/13![Frontier logo]()
$170
This Frontier deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/179:40 pm -
1 stop19h 54m
Mon 9/215:19 pm -
1 stop14h 16m
Deal found 8/17![Frontier logo]()
$177
This CheapOair deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/109:40 pm -
1 stop19h 54m
Fri 9/185:19 pm -
1 stop14h 16m
Deal found 8/16![Frontier logo]()
$186
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/284:59 pm -
1 stop6h 22m
Sat 8/294:00 pm -
1 stop6h 57m
Deal found 8/13![Delta logo]()
$187
This CheapOair deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/247:16 pm -
1 stop22h 18m
Mon 9/285:19 pm -
1 stop14h 16m
Deal found 8/13![Frontier logo]()
$188
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:50 am -
Nonstop1h 55m
Mon 9/143:45 pm -
1 stop5h 10m
Deal found 8/12![Southwest logo]()
$192
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:50 pm -
1 stop5h 35m
Tue 10/138:30 am -
1 stop4h 00m
Deal found 8/12![Southwest logo]()
$192
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2711:15 am -
Nonstop1h 55m
Tue 11/33:00 pm -
Nonstop1h 40m
Deal found 8/13![Southwest logo]()
$196
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:50 pm -
Nonstop1h 52m
Mon 9/218:43 am -
Nonstop1h 57m
Deal found 8/14![American Airlines logo]()
$197
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:30 am -
1 stop6h 23m
Thu 8/276:06 am -
1 stop6h 20m
Deal found 8/12![Delta logo]()
$197
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:43 am -
1 stop4h 10m
Tue 9/82:26 pm -
1 stop6h 15m
Deal found 8/12![Delta logo]()
$197
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:34 pm -
Nonstop1h 56m
Mon 9/1410:21 am -
Nonstop1h 54m
Deal found 8/12![American Airlines logo]()
$198
Best flights from South Carolina to MissouriDiscover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 17, 2026.
Discover carefully curated flight deals from South Carolina to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 17, 2026.
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/119:42 am -
1 stop6h 03m
Sat 11/144:00 pm -
1 stop6h 54m
Deal found 8/13![Delta logo]()
$187
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:50 pm -
1 stop5h 35m
Tue 10/138:30 am -
1 stop4h 00m
Deal found 8/12![Southwest logo]()
$192
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:01 pm -
1 stop4h 59m
Thu 9/1012:28 pm -
1 stop7h 16m
Deal found 8/14![United Airlines logo]()
$217
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:32 am -
1 stop4h 32m
Tue 9/295:13 am -
1 stop4h 50m
Deal found 8/15![American Airlines logo]()
$259
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:02 pm -
1 stop6h 06m
Wed 9/163:19 pm -
1 stop3h 54m
Deal found 8/12![Delta logo]()
$197
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:50 am -
Nonstop1h 55m
Sun 9/610:35 am -
1 stop5h 40m
Deal found 8/13![Southwest logo]()
$216
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:43 am -
1 stop4h 10m
Tue 9/82:26 pm -
1 stop6h 15m
Deal found 8/12![Delta logo]()
$197
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/155:45 am -
2 stops7h 12m
Wed 9/167:56 am -
1 stop5h 02m
Deal found 8/16![United Airlines logo]()
$232
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/46:40 am -
1 stop5h 50m
Tue 9/811:20 am -
1 stop6h 55m
Deal found 8/12![Southwest logo]()
$216
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:35 am -
1 stop4h 57m
Mon 9/146:54 pm -
1 stop4h 05m
Deal found 8/14![Delta logo]()
$227
This Delta deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:30 am -
1 stop3h 39m
Mon 10/125:35 pm -
1 stop5h 24m
Deal found 8/15![Delta logo]()
$227
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:09 am -
2 stops10h 23m
Sun 9/67:30 am -
1 stop6h 23m
Deal found 8/16![United Airlines logo]()
$291
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:30 pm -
1 stop5h 10m
Wed 10/76:20 am -
2 stops8h 55m
Deal found 8/13![Southwest logo]()
$281
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:30 am -
1 stop4h 30m
Thu 9/246:54 pm -
1 stop4h 05m
Deal found 8/17![Delta logo]()
$238
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:10 am -
1 stop7h 20m
Mon 11/27:30 am -
2 stops13h 11m
Deal found 8/16![United Airlines logo]()
$302
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/12:04 pm -
1 stop7h 22m
Sun 9/63:35 pm -
1 stop5h 52m
Deal found 8/13![American Airlines logo]()
$367
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:50 am -
Nonstop1h 55m
Tue 9/83:45 pm -
1 stop4h 30m
Deal found 8/12![Southwest logo]()
$287
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1511:27 am -
1 stop5h 16m
Mon 10/198:00 am -
1 stop5h 04m
Deal found 8/16![United Airlines logo]()
$307
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/245:45 am -
1 stop4h 37m
Mon 9/285:30 pm -
1 stop4h 25m
Deal found 8/16![Delta logo]()
$259
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:50 pm -
1 stop4h 25m
Mon 10/121:00 pm -
1 stop7h 25m
Deal found 8/12![Southwest logo]()
$287
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:12 pm -
1 stop4h 06m
Sun 10/256:00 am -
1 stop7h 45m
Deal found 8/16![American Airlines logo]()
$400
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:00 am -
2 stops9h 43m
Mon 11/21:08 pm -
1 stop7h 58m
Deal found 8/17![United Airlines logo]()
$312
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/22:25 pm -
2 stops8h 15m
Tue 9/810:45 am -
1 stop5h 55m
Deal found 8/12![Southwest logo]()
$294
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:10 am -
1 stop4h 36m
Sat 9/53:44 pm -
1 stop5h 07m
Deal found 8/13![Delta logo]()
$274
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/206:15 pm -
1 stop6h 26m
Fri 9/251:54 pm -
1 stop6h 14m
Deal found 8/14![American Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:10 am -
1 stop5h 35m
Fri 10/1611:20 am -
1 stop7h 56m
Deal found 8/12![United Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/910:40 am -
Nonstop1h 55m
Sun 10/117:00 am -
1 stop4h 35m
Deal found 8/12![Southwest logo]()
$295
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/122:18 pm -
1 stop4h 22m
Sun 11/158:05 am -
1 stop4h 28m
Deal found 8/14![Delta logo]()
$278
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:00 am -
1 stop5h 14m
Sun 8/305:42 am -
1 stop6h 52m
Deal found 8/15![American Airlines logo]()
$429
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:25 am -
1 stop5h 25m
Wed 9/166:00 am -
2 stops7h 21m
Deal found 8/14![United Airlines logo]()
$323
Last-minute flights from South Carolina to MissouriDiscover last-minute flight deals from South Carolina to Missouri. Data last updated August 17, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Missouri. Data last updated August 17, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:30 am -
1 stop6h 23m
Thu 8/276:06 am -
1 stop6h 20m
Deal found 8/12![Delta logo]()
$197
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/284:59 pm -
1 stop6h 22m
Sat 8/294:00 pm -
1 stop6h 57m
Deal found 8/13![Delta logo]()
$187
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/212:10 pm -
Nonstop1h 52m
Sun 9/67:35 am -
Nonstop1h 55m
Deal found 8/13![American Airlines logo]()
$206
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:43 am -
1 stop4h 10m
Tue 9/82:26 pm -
1 stop6h 15m
Deal found 8/12![Delta logo]()
$197
This CheapOair deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/109:32 am -
1 stop9h 22m
Mon 9/145:19 pm -
1 stop20h 57m
Deal found 8/13![Frontier logo]()
$170
This CheapOair deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/109:32 am -
1 stop9h 22m
Fri 9/115:19 pm -
1 stop14h 16m
Deal found 8/16![Frontier logo]()
$186
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:50 am -
Nonstop1h 55m
Mon 9/143:45 pm -
1 stop5h 10m
Deal found 8/12![Southwest logo]()
$192
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:34 pm -
Nonstop1h 56m
Mon 9/1410:21 am -
Nonstop1h 54m
Deal found 8/12![American Airlines logo]()
$198
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:50 pm -
Nonstop1h 52m
Mon 9/218:43 am -
Nonstop1h 57m
Deal found 8/14![American Airlines logo]()
$197
This Frontier deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/179:40 pm -
1 stop19h 54m
Mon 9/215:19 pm -
1 stop14h 16m
Deal found 8/17![Frontier logo]()
$177
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/179:50 pm -
Nonstop1h 52m
Thu 9/246:53 am -
Nonstop1h 57m
Deal found 8/13![American Airlines logo]()
$199
This CheapOair deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/247:16 pm -
1 stop22h 18m
Mon 9/285:19 pm -
1 stop14h 16m
Deal found 8/13![Frontier logo]()
$188
One-way flights from South Carolina to MissouriSearch for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated August 17, 2026.
Search for one-way flight options from South Carolina to Missouri. Find affordable one-way fares based on user searches. Data last updated August 17, 2026.
This Expedia deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:56 am -
1 stop8h 15m
Deal found 8/13![Frontier logo]()
$80
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:50 am -
Nonstop1h 55m
Deal found 8/13![Southwest logo]()
$82
This Priceline deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/19:32 am -
1 stop9h 22m
Deal found 8/13![Frontier logo]()
$86
This CheapOair deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/29:52 pm -
1 stop19h 19m
Deal found 8/12![Frontier logo]()
$87
This Frontier deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/119:32 am -
1 stop8h 02m
Deal found 8/13![Frontier logo]()
$88
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:45 am -
Nonstop2h 00m
Deal found 8/12![Southwest logo]()
$90
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:15 pm -
1 stop4h 30m
Deal found 8/12![Southwest logo]()
$92
This Expedia deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:16 pm -
1 stop22h 18m
Deal found 8/14![Frontier logo]()
$94
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/304:59 pm -
1 stop6h 22m
Deal found 8/13![Delta logo]()
$94
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1311:25 am -
1 stop8h 13m
Deal found 8/13![United Airlines logo]()
$94
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:45 pm -
1 stop4h 25m
Deal found 8/13![Southwest logo]()
$96
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:29 pm -
1 stop4h 55m
Deal found 8/13![American Airlines logo]()
$97
Find flight deals from South Carolina to Missouri
Keep the following information in mind while searching for South Carolina to Missouri flight deals. Data was last updated August 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $170 (CheapOair) |
One-way from | $80 (Expedia) |
Popular in | December |
Cheapest in | August |
Average price | $286 |
Good round-trip deal | $245 or less |
Good one-way deal | $208 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteSpringfield
CLT Charlotte Douglas - SGF Springfield-Branson
CLTSGF
Charlotte Douglas
Wed 11/11
9:42 am-2:45 pm
1 stop6h 03m
Springfield-Branson
Sat 11/14
4:00 pm-11:54 pm
1 stop6h 54m
$187
Myrtle BeachKansas City
MYR Myrtle Beach Intl - MCI Kansas City
MYRMCI
Myrtle Beach Intl
Thu 10/8
7:50 pm-12:25 am
1 stop5h 35m
Kansas City
Tue 10/13
8:30 am-1:30 pm
1 stop4h 00m
$192
CharlotteSpringfield
CLT Charlotte Douglas - SGF Springfield-Branson
CLTSGF
Charlotte Douglas
Wed 9/9
5:02 pm-10:08 pm
1 stop6h 06m
Springfield-Branson
Wed 9/16
3:19 pm-8:13 pm
1 stop3h 54m
$197
Myrtle BeachKansas City
MYR Myrtle Beach Intl - MCI Kansas City
MYRMCI
Myrtle Beach Intl
Thu 9/3
11:43 am-2:53 pm
1 stop4h 10m
Kansas City
Tue 9/8
2:26 pm-9:41 pm
1 stop6h 15m
$197
CharlotteSt. Louis
CLT Charlotte Douglas - STL Lambert-St Louis
CLTSTL
Charlotte Douglas
Thu 9/3
11:50 am-12:45 pm
Nonstop1h 55m
Lambert-St Louis
Sun 9/6
10:35 am-5:15 pm
1 stop5h 40m
$216
Myrtle BeachKansas City
MYR Myrtle Beach Intl - MCI Kansas City
MYRMCI
Myrtle Beach Intl
Fri 9/4
6:40 am-11:30 am
1 stop5h 50m
Kansas City
Tue 9/8
11:20 am-7:15 pm
1 stop6h 55m
$216
CharlotteSt. Louis
CLT Charlotte Douglas - STL Lambert-St Louis
CLTSTL
Charlotte Douglas
Tue 9/8
6:01 pm-10:00 pm
1 stop4h 59m
Lambert-St Louis
Thu 9/10
12:28 pm-8:44 pm
1 stop7h 16m
$217
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Thu 9/10
8:35 am-12:32 pm
1 stop4h 57m
Lambert-St Louis
Mon 9/14
6:54 pm-11:59 pm
1 stop4h 05m
$227
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Thu 10/8
6:30 am-9:09 am
1 stop3h 39m
Lambert-St Louis
Mon 10/12
5:35 pm-11:59 pm
1 stop5h 24m
$227
CharlestonSt. Louis
CHS Charleston - STL Lambert-St Louis
CHSSTL
Charleston
Tue 9/15
5:45 am-11:57 am
2 stops7h 12m
Lambert-St Louis
Wed 9/16
7:56 am-1:58 pm
1 stop5h 02m
$232
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from South Carolina to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.
CHS-STL
CLT-SGF
GSP-MCI
CLT-STL
MYR-MCI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Missouri
USSC-USMO
CHS-STL
CLT-SGF
GSP-MCI
CLT-STL
What is the cheapest month to book a flight from South Carolina to Missouri?
Currently, September is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $336). Flying from South Carolina to Missouri in December is currently the most expensive (average of $466). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to MO?
Find hourly flight availability from South Carolina to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 17, 2026.
It’s optimal to fly from South Carolina to Missouri in the evening. By choosing this option you can save up to 37% on the cost of your flight, compared to a flight at noon.
How much does it cost to fly round-trip from South Carolina to Missouri?
Airfare is below average for this route at the moment.
South Carolina to Missouri flights typically cost between $321 and $434 in September.The cheapest round-trip price found within the last 5 days was $217 on Southwest (Sep 24-Sep 28).
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated August 17, 2026.
Read through reviews of airlines operating flights from South Carolina to Missouri, such as Southwest,Delta, andUnited Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for South Carolina to Missouri
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from South Carolina to Missouri by cabin class
Find flights from South Carolina to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
South Carolina and Missouri flights
Browse other South Carolina and Missouri flight options. Last updated on August 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Missouri
Find the right flight back to South Carolina after your stay in Missouri
South Carolina to Missouri flights
Consider these flights traveling from South Carolina to Missouri.
Top 4 airlines flying from South Carolina to Missouri
Discover the top 4 airlines that operate flights from South Carolina to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$158 | Average$412 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$228 | Average$419 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$248 | Average$392 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$405 | FlexibilityNo cancel fee | On-time71% |