$70+ Cheap flights from Missouri to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/23. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Jun 4 — Jun 111
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to South Carolina
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Cheapest flights from Missouri to South CarolinaExplore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
This CheapOair deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:45 pm
MCI
- CLT
1 stop6h 40m
Frontier
Wed 7/810:14 pm
CLT
- MCI
1 stop15h 41m
Frontier
Deal found 4/30![Frontier logo]()
$215
This CheapOair deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/201:45 pm
MCI
- CLT
1 stop6h 40m
Frontier
Wed 6/2410:14 pm
CLT
- MCI
1 stop15h 46m
Frontier
Deal found 5/1![Frontier logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- CHS
2 stops14h 05m
Multiple Airlines
Tue 6/210:38 am
CHS
- STL
1 stop14h 19m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$221
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:45 pm
STL
- CHS
1 stop6h 20m
Southwest
Tue 6/23:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 5/2![Southwest logo]()
$222
This CheapOair deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/232:34 pm
MCI
- CLT
1 stop26h 44m
Frontier
Tue 5/267:14 pm
CLT
- MCI
1 stop19h 35m
Frontier
Deal found 5/4![Frontier logo]()
$225
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:14 am
STL
- CHS
1 stop5h 54m
American Airlines
Tue 6/26:37 am
CHS
- STL
1 stop8h 49m
American Airlines
Deal found 5/2![American Airlines logo]()
$227
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/252:10 pm
STL
- CHS
Nonstop1h 55m
Southwest
Wed 5/273:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 5/4![Southwest logo]()
$228
This CheapOair deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/101:45 pm
MCI
- CLT
1 stop6h 38m
Frontier
Mon 8/1710:14 pm
CLT
- MCI
1 stop15h 46m
Frontier
Deal found 5/2![Frontier logo]()
$229
This CheapOair deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/181:45 pm
MCI
- CLT
1 stop6h 38m
Frontier
Sun 7/197:14 pm
CLT
- MCI
1 stop18h 41m
Frontier
Deal found 5/4![Frontier logo]()
$234
This CheapOair deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/171:45 pm
MCI
- CLT
1 stop6h 38m
Frontier
Thu 7/237:14 pm
CLT
- MCI
1 stop18h 41m
Frontier
Deal found 5/4![Frontier logo]()
$240
This CheapOair deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/211:45 pm
MCI
- CLT
1 stop6h 39m
Frontier
Sun 8/237:14 pm
CLT
- MCI
1 stop18h 46m
Frontier
Deal found 4/30![Frontier logo]()
$241
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:12 pm
STL
- CHS
1 stop4h 47m
American Airlines
Tue 6/27:51 pm
CHS
- STL
1 stop5h 23m
American Airlines
Deal found 5/1![American Airlines logo]()
$243
Best flights from Missouri to South CarolinaDiscover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
Discover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:01 pm
STL
- CLT
1 stop3h 52m
Delta
Sun 6/76:00 am
CLT
- STL
1 stop4h 32m
Delta
Deal found 5/1![Delta logo]()
$291
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:00 am
STL
- CLT
1 stop8h 09m
United Airlines
Wed 6/310:24 am
CLT
- STL
1 stop6h 22m
United Airlines
Deal found 5/4![United Airlines logo]()
$297
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/233:00 pm
STL
- CLT
2 stops7h 30m
Southwest
Mon 10/261:20 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 5/4![Southwest logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:24 pm
MCI
- CHS
2 stops19h 58m
Multiple Airlines
Wed 6/108:56 pm
CHS
- MCI
1 stop14h 14m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$323
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:18 am
MCI
- MYR
1 stop6h 33m
American Airlines
Wed 5/2711:15 am
MYR
- MCI
1 stop6h 23m
American Airlines
Deal found 5/2![American Airlines logo]()
$406
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:40 pm
STL
- CLT
1 stop4h 20m
Southwest
Sun 5/3112:50 pm
CLT
- STL
Nonstop2h 05m
Southwest
Deal found 5/1![Southwest logo]()
$300
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:30 am
STL
- CLT
2 stops6h 38m
United Airlines
Tue 5/268:05 am
CLT
- STL
1 stop5h 06m
United Airlines
Deal found 5/3![United Airlines logo]()
$306
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/188:00 am
STL
- CLT
1 stop4h 31m
Delta
Wed 7/226:59 am
CLT
- STL
1 stop3h 44m
Delta
Deal found 4/30![Delta logo]()
$315
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2011:35 am
STL
- CLT
2 stops8h 20m
Southwest
Tue 5/267:20 pm
CLT
- STL
1 stop3h 40m
Southwest
Deal found 5/4![Southwest logo]()
$306
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:00 am
STL
- CHS
1 stop7h 16m
United Airlines
Wed 6/33:08 pm
CHS
- STL
1 stop7h 13m
United Airlines
Deal found 5/4![United Airlines logo]()
$307
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:30 am
STL
- CLT
1 stop4h 54m
Delta
Wed 7/226:59 am
CLT
- STL
1 stop3h 44m
Delta
Deal found 4/30![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/97:05 pm
STL
- CLT
1 stop3h 10m
Southwest
Mon 7/134:40 pm
CLT
- STL
Nonstop2h 10m
Southwest
Deal found 5/4![Southwest logo]()
$313
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/267:12 pm
STL
- CLT
1 stop3h 47m
Delta
Sun 6/286:00 am
CLT
- STL
1 stop4h 32m
Delta
Deal found 4/30![Delta logo]()
$323
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/63:45 pm
STL
- SAV
Nonstop1h 55m
Southwest
Mon 6/81:15 pm
SAV
- STL
1 stop6h 25m
Southwest
Deal found 4/30![Southwest logo]()
$323
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/257:12 pm
STL
- CLT
1 stop3h 47m
Delta
Mon 6/299:42 am
CLT
- STL
1 stop3h 52m
Delta
Deal found 5/4![Delta logo]()
$323
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:00 am
STL
- MYR
1 stop7h 02m
United Airlines
Wed 6/36:50 pm
MYR
- STL
1 stop5h 45m
United Airlines
Deal found 5/4![United Airlines logo]()
$371
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1211:27 am
SGF
- CLT
Nonstop2h 16m
American Airlines
Tue 6/1611:25 am
CLT
- SGF
Nonstop2h 27m
American Airlines
Deal found 4/30![American Airlines logo]()
$460
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/191:39 pm
STL
- CLT
1 stop3h 40m
Delta
Sun 6/216:00 am
CLT
- STL
1 stop4h 32m
Delta
Deal found 5/3![Delta logo]()
$323
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/253:35 pm
STL
- CHS
1 stop6h 15m
Southwest
Mon 6/291:30 pm
CHS
- STL
1 stop6h 45m
Southwest
Deal found 5/4![Southwest logo]()
$337
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1112:30 pm
MCI
- SAV
1 stop6h 18m
United Airlines
Wed 7/1512:10 pm
SAV
- MCI
1 stop7h 53m
United Airlines
Deal found 5/2![United Airlines logo]()
$402
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:25 am
MCI
- HHH
2 stops8h 07m
Delta
Mon 6/224:15 pm
HHH
- MCI
1 stop7h 13m
Delta
Deal found 5/2![Delta logo]()
$336
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:03 am
MCI
- HHH
2 stops10h 29m
American Airlines
Fri 10/3012:35 pm
HHH
- MCI
2 stops8h 42m
American Airlines
Deal found 5/2![American Airlines logo]()
$493
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:20 am
MCI
- SAV
1 stop6h 20m
Southwest
Wed 9/308:00 am
SAV
- MCI
2 stops9h 20m
Southwest
Deal found 4/30![Southwest logo]()
$340
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/189:16 am
STL
- SAV
1 stop8h 03m
United Airlines
Wed 8/198:00 am
SAV
- STL
1 stop5h 13m
United Airlines
Deal found 5/1![United Airlines logo]()
$407
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2010:16 am
STL
- SAV
1 stop3h 32m
Delta
Sat 6/276:00 am
SAV
- STL
1 stop4h 08m
Delta
Deal found 5/3![Delta logo]()
$341
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/612:46 pm
SGF
- CLT
1 stop6h 01m
American Airlines
Mon 6/811:25 am
CLT
- SGF
Nonstop2h 27m
American Airlines
Deal found 5/3![American Airlines logo]()
$500
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:40 am
STL
- CHS
2 stops6h 50m
Southwest
Tue 7/148:15 pm
CHS
- STL
1 stop3h 45m
Southwest
Deal found 5/2![Southwest logo]()
$342
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/311:13 pm
STL
- CHS
1 stop7h 38m
United Airlines
Wed 6/36:00 am
CHS
- STL
2 stops10h 46m
United Airlines
Deal found 5/2![United Airlines logo]()
$407
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/298:00 am
STL
- SAV
1 stop5h 48m
Delta
Fri 7/35:39 am
SAV
- STL
1 stop5h 07m
Delta
Deal found 5/1![Delta logo]()
$341
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1812:50 pm
STL
- SAV
1 stop5h 55m
Southwest
Wed 7/226:45 am
SAV
- STL
2 stops9h 05m
Southwest
Deal found 5/2![Southwest logo]()
$346
Last-minute flights from Missouri to South CarolinaDiscover last-minute flight deals from Missouri to South Carolina. Data last updated May 5, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South Carolina. Data last updated May 5, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/232:34 pm
MCI
- CLT
1 stop26h 44m
Frontier
Tue 5/267:14 pm
CLT
- MCI
1 stop19h 35m
Frontier
Deal found 5/4![Frontier logo]()
$225
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/252:10 pm
STL
- CHS
Nonstop1h 55m
Southwest
Wed 5/273:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 5/4![Southwest logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- CHS
2 stops14h 05m
Multiple Airlines
Tue 6/210:38 am
CHS
- STL
1 stop14h 19m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$221
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:45 pm
STL
- CHS
1 stop6h 20m
Southwest
Tue 6/23:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 5/2![Southwest logo]()
$222
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:14 am
STL
- CHS
1 stop5h 54m
American Airlines
Tue 6/26:37 am
CHS
- STL
1 stop8h 49m
American Airlines
Deal found 5/2![American Airlines logo]()
$227
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/279:13 am
STL
- CHS
1 stop5h 36m
Delta
Mon 6/17:59 pm
CHS
- STL
1 stop5h 00m
Delta
Deal found 5/4![Delta logo]()
$256
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:12 pm
STL
- CHS
1 stop4h 47m
American Airlines
Tue 6/27:51 pm
CHS
- STL
1 stop5h 23m
American Airlines
Deal found 5/1![American Airlines logo]()
$243
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:20 pm
STL
- CHS
Nonstop1h 55m
Southwest
Mon 6/17:55 pm
CHS
- STL
1 stop4h 20m
Southwest
Deal found 5/5![Southwest logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/44:19 pm
STL
- MYR
1 stop15h 46m
Multiple Airlines
Mon 6/89:52 pm
MYR
- STL
2 stops35h 55m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$257
This CheapOair deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/131:45 pm
MCI
- CLT
1 stop6h 40m
Frontier
Sat 6/2010:14 pm
CLT
- MCI
1 stop15h 46m
Frontier
Deal found 5/1![Frontier logo]()
$255
This CheapOair deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/191:45 pm
MCI
- CLT
1 stop6h 40m
Frontier
Mon 6/2210:14 pm
CLT
- MCI
1 stop15h 46m
Frontier
Deal found 5/1![Frontier logo]()
$241
This CheapOair deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/201:45 pm
MCI
- CLT
1 stop6h 40m
Frontier
Wed 6/2410:14 pm
CLT
- MCI
1 stop15h 46m
Frontier
Deal found 5/1![Frontier logo]()
$221
One-way flights from Missouri to South CarolinaSearch for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
Search for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated May 5, 2026.
This Priceline deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:30 pm
STL
- CLT
1 stop11h 29m
Frontier
Deal found 5/1![Frontier logo]()
$70
This Frontier deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:06 pm
STL
- CLT
1 stop8h 53m
Frontier
Deal found 5/4![Frontier logo]()
$90
This Frontier deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/249:06 pm
STL
- CLT
1 stop8h 53m
Frontier
Deal found 4/30![Frontier logo]()
$95
This Priceline deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/291:45 pm
MCI
- CLT
1 stop6h 38m
Frontier
Deal found 5/5![Frontier logo]()
$95
This Trip.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Deal found 4/30![Frontier logo]()
$98
This Southwest deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/164:50 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 5/2![Southwest logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:31 pm
STL
- CLT
2 stops26h 04m
Frontier
Deal found 5/4![Frontier logo]()
$101
This Expedia deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:45 pm
MCI
- CLT
1 stop27h 33m
Frontier
Deal found 5/3![Frontier logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/265:06 pm
STL
- SAV
2 stops40h 19m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:27 pm
STL
- CLT
2 stops18h 48m
Frontier
Deal found 5/2![Frontier logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:33 pm
STL
- CLT
2 stops28h 07m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/266:16 pm
MCI
- SAV
2 stops39h 09m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$107
Find flight deals from Missouri to South Carolina
Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated May 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $215 (CheapOair) |
One-way from | $70 (Priceline) |
Popular in | April |
Cheapest in | February |
Average price | $357 |
Good round-trip deal | $356 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Thu 6/4
7:01 pm-11:53 pm
1 stop3h 52m
Charlotte Douglas
Sun 6/7
6:00 am-9:32 am
1 stop4h 32m
$291
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Tue 6/2
6:00 am-3:09 pm
1 stop8h 09m
Charlotte Douglas
Wed 6/3
10:24 am-3:46 pm
1 stop6h 22m
$297
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Fri 10/23
3:00 pm-11:30 pm
2 stops7h 30m
Charlotte Douglas
Mon 10/26
1:20 pm-2:20 pm
Nonstop2h 00m
$299
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Fri 5/29
4:40 pm-10:00 pm
1 stop4h 20m
Charlotte Douglas
Sun 5/31
12:50 pm-1:55 pm
Nonstop2h 05m
$300
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Tue 5/19
6:30 am-2:08 pm
2 stops6h 38m
Charlotte Douglas
Tue 5/26
8:05 am-12:11 pm
1 stop5h 06m
$306
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 5/20
11:35 am-8:55 pm
2 stops8h 20m
Charlotte Douglas
Tue 5/26
7:20 pm-10:00 pm
1 stop3h 40m
$306
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 6/2
6:00 am-2:16 pm
1 stop7h 16m
Charleston
Wed 6/3
3:08 pm-9:21 pm
1 stop7h 13m
$307
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Thu 7/9
7:05 pm-11:15 pm
1 stop3h 10m
Charlotte Douglas
Mon 7/13
4:40 pm-5:50 pm
Nonstop2h 10m
$313
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 7/18
8:00 am-1:31 pm
1 stop4h 31m
Charlotte Douglas
Wed 7/22
6:59 am-9:43 am
1 stop3h 44m
$315
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Fri 7/17
6:30 am-12:24 pm
1 stop4h 54m
Charlotte Douglas
Wed 7/22
6:59 am-9:43 am
1 stop3h 44m
$319
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
MCI-CLT
STL-CHS
STL-MYR
STL-CLT
STL-SAV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South Carolina
USMO-USSC
MCI-CLT
STL-CHS
STL-MYR
STL-CLT
How far ahead should I book a flight from Missouri to South Carolina?
The price you pay for your flight from Missouri to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 53 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Missouri to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $89). Flying from Missouri to South Carolina in January is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SC?
Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 5, 2026.
When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from Missouri to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated May 5, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
7.9
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South Carolina by cabin class
Find flights from Missouri to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South Carolina flights
Browse other Missouri and South Carolina flight options. Last updated on May 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Missouri after your stay in South Carolina
Missouri to South Carolina flights
Consider these flights traveling from Missouri to South Carolina.
Top 5 airlines flying from Missouri to South Carolina
Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$99 | Average$367 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$172 | Average$403 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$176 | Average$218 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$196 | Average$391 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$237 | Average$407 | FlexibilityNo cancel fee | On-time63% |