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South Carolina

$64+ Cheap flights from Missouri to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Jul 21 — Jul 281
Mon 7/21
Mon 7/28
1 adult, Economy
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Cheap flight deals from Missouri to South Carolina

Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated July 16, 2025.

Round-trip from

$179
(FlightHub)

One-way from

$64
(Booking.com)

Popular in

March

Cheapest in

September

Average price

$396

Good round-trip deal

$286 or less
From Missouri to South Carolina
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One-way flight from Missouri to South Carolina
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Highest demand for flights based on searches. 7% potential increase in price ($31 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a round-trip flight from Missouri to South Carolina.
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Find flight deals from Missouri to South Carolina

Cheapest flights from Missouri to South Carolina
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 16, 2025.

This FlightHub deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/138:44 amSTL - CLT
1 stop6h 15mSpirit Airlines
Sun 11/165:04 pmCLT - STL
1 stop15h 45mSpirit Airlines
Deal found 7/14$168
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/197:34 amSTL - CLT
Nonstop1h 56mAmerican Airlines
Wed 11/191:16 pmCLT - STL
1 stop7h 44mAmerican Airlines
Deal found 7/16$174
This FlightHub deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/182:30 pmSTL - MYR
1 stop4h 23mSpirit Airlines
Sat 8/235:20 pmMYR - STL
1 stop21h 12mSpirit Airlines
Deal found 7/16$179
This FlightHub deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/84:23 pmMCI - MYR
1 stop4h 54mSpirit Airlines
Fri 8/156:31 pmMYR - MCI
1 stop5h 22mSpirit Airlines
Deal found 7/15$203
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/129:45 amSTL - MYR
1 stop5h 15mSouthwest
Tue 8/196:30 amMYR - STL
1 stop7h 05mSouthwest
Deal found 7/15$207
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/122:45 pmSTL - MYR
2 stops7h 26mAmerican Airlines
Tue 8/191:12 pmMYR - STL
1 stop4h 44mAmerican Airlines
Deal found 7/15$212
This FlightHub deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/278:44 amSTL - CLT
1 stop6h 15mMultiple Airlines
Mon 11/35:34 pmCLT - STL
1 stop16h 33mMultiple Airlines
Deal found 7/14$215
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1610:25 amSTL - SAV
Nonstop1h 50mSouthwest
Sat 8/231:50 pmSAV - STL
Nonstop2h 05mSouthwest
Deal found 7/15$217
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/117:50 amSTL - CHS
Nonstop1h 55mSouthwest
Mon 8/1811:25 amCHS - STL
Nonstop2h 05mSouthwest
Deal found 7/15$217
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/82:45 pmSTL - CLT
Nonstop1h 50mSouthwest
Mon 8/117:50 pmCLT - STL
Nonstop2h 00mSouthwest
Deal found 7/15$221
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/244:06 pmMCI - MYR
1 stop6h 43mDelta
Mon 9/2910:55 amMYR - MCI
1 stop5h 06mDelta
Deal found 7/15$227
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/45:11 pmSTL - MYR
1 stop5h 38mDelta
Thu 9/1111:34 amMYR - STL
1 stop6h 03mDelta
Deal found 7/15$227

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 16, 2025.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.

Fly from

Missouri

Fly to

South Carolina

Route

Depart

Return

Price

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

Mon 8/18

2:30 pm-7:53 pm

1 stop4h 23m

Myrtle Beach Intl

Sat 8/23

5:20 pm-1:32 pm

1 stop21h 12m

$179

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 8/14

2:30 pm-1:10 pm

1 stop21h 40m

Charlotte Douglas

Thu 8/21

2:14 pm-1:32 pm

1 stop24h 18m

$184

Kansas CityMyrtle Beach

MCI - MYR

MCIMYR

Kansas City

Fri 8/8

4:23 pm-10:17 pm

1 stop4h 54m

Myrtle Beach Intl

Fri 8/15

6:31 pm-10:53 pm

1 stop5h 22m

$203

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

Tue 8/12

9:45 am-4:00 pm

1 stop5h 15m

Myrtle Beach Intl

Tue 8/19

6:30 am-12:35 pm

1 stop7h 05m

$207

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

Tue 8/12

2:45 pm-11:11 pm

2 stops7h 26m

Myrtle Beach Intl

Tue 8/19

1:12 pm-4:56 pm

1 stop4h 44m

$212

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Sat 8/16

10:25 am-1:15 pm

Nonstop1h 50m

Savannah/Hilton Head

Sat 8/23

1:50 pm-2:55 pm

Nonstop2h 05m

$217

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 9/9

3:10 pm-6:00 pm

Nonstop1h 50m

Charlotte Douglas

Thu 9/11

7:50 pm-8:50 pm

Nonstop2h 00m

$217

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Mon 8/11

7:50 am-10:45 am

Nonstop1h 55m

Charleston

Mon 8/18

11:25 am-12:30 pm

Nonstop2h 05m

$217

Kansas CityMyrtle Beach

MCI - MYR

MCIMYR

Kansas City

Wed 9/24

4:06 pm-11:49 pm

1 stop6h 43m

Myrtle Beach Intl

Mon 9/29

10:55 am-3:01 pm

1 stop5h 06m

$227

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Sat 9/6

1:05 pm-8:08 pm

1 stop6h 03m

Savannah/Hilton Head

Sat 9/13

6:40 am-12:21 pm

1 stop6h 41m

$227

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/14

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South Carolina

What is the cheapest month to book a flight from Missouri to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SC?

Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 16, 2025.

When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

How much does it cost to fly round-trip from Missouri to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated July 16, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,959 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,863 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Spirit Airlines
6.3
Okay
8,043 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Boarding

8.1

Comfort

8.0

Overall

8.0

Entertainment

7.6

Crew

8.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Missouri to South Carolina flight route?

    The Missouri to South Carolina flight path was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Missouri to South Carolina one-way?

    For one-way options, check prices for Spirit Airlines. According to our data, you can fly for as low as $64. Users have also found prices from $79 and $94 on Southwest and American Airlines, respectively.

  • Can I find deals for flights from Missouri to South Carolina that include hotel bookings?

    Yes. In addition to deals on Missouri to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South Carolina.

  • Can I find deals for business class flights from Missouri to South Carolina?

    Yes. Cheapflights offers flight deals from Missouri to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to South Carolina

Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$112Average$234FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$178Average$410FlexibilityNo cancel feeOn-time71%
DeltaCheapest$196Average$376FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$223Average$441FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$276Average$399FlexibilityNo cancel feeOn-time63%

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