$89+ Cheap flights from Missouri to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/26. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — CHS
Jul 6 — Jul 131
Round-trip
1 adult, Economy
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Cheapest flights from Missouri to South CarolinaExplore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 6, 2026.
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 6, 2026.
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/98:30 am
STL
- CHS
1 stop6h 10m
American Airlines
Tue 9/151:11 pm
CHS
- STL
1 stop6h 56m
American Airlines
Deal found 6/1![American Airlines logo]()
$177
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/205:38 am
MCI
- CLT
1 stop6h 57m
Delta
Sun 6/218:01 am
CLT
- MCI
1 stop5h 14m
Delta
Deal found 6/3![Delta logo]()
$187
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:00 am
STL
- CHS
1 stop6h 04m
Delta
Mon 9/217:13 pm
CHS
- STL
1 stop5h 23m
Delta
Deal found 6/1![Delta logo]()
$191
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/23:38 pm
MCI
- CLT
1 stop7h 21m
Delta
Sun 7/56:00 am
CLT
- MCI
1 stop4h 48m
Delta
Deal found 6/2![Delta logo]()
$207
This American Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:12 pm
STL
- CLT
Nonstop2h 03m
American Airlines
Wed 7/2910:56 pm
CLT
- STL
Nonstop2h 02m
American Airlines
Deal found 6/4![American Airlines logo]()
$217
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:25 am
MCI
- CLT
1 stop5h 01m
Delta
Wed 6/176:59 am
CLT
- MCI
1 stop6h 16m
Delta
Deal found 6/3![Delta logo]()
$221
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:43 am
STL
- CHS
1 stop5h 48m
American Airlines
Tue 9/227:41 pm
CHS
- STL
1 stop4h 01m
American Airlines
Deal found 6/1![American Airlines logo]()
$224
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:40 am
STL
- CLT
1 stop4h 30m
Southwest
Wed 7/81:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/3![Southwest logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/24:10 pm
STL
- CHS
1 stop15h 28m
Multiple Airlines
Wed 9/96:00 am
CHS
- STL
2 stops28h 40m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$228
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:00 am
STL
- CHS
1 stop4h 05m
Delta
Sat 9/1912:36 pm
CHS
- STL
1 stop5h 05m
Delta
Deal found 6/1![Delta logo]()
$235
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:00 am
STL
- CLT
1 stop6h 35m
Delta
Tue 6/306:00 am
CLT
- STL
1 stop4h 46m
Delta
Deal found 6/2![Delta logo]()
$237
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/13:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Tue 7/71:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Deal found 6/3![Southwest logo]()
$237
Best flights from Missouri to South CarolinaDiscover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 6, 2026.
Discover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 6, 2026.
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/92:10 pm
MCI
- CLT
1 stop6h 47m
Delta
Sun 7/125:30 am
CLT
- MCI
1 stop5h 08m
Delta
Deal found 6/3![Delta logo]()
$187
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:40 am
STL
- CLT
2 stops7h 55m
Southwest
Wed 7/88:15 pm
CLT
- STL
1 stop3h 50m
Southwest
Deal found 6/3![Southwest logo]()
$242
This United Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:25 am
STL
- CLT
1 stop5h 31m
United Airlines
Mon 9/78:05 am
CLT
- STL
1 stop4h 57m
United Airlines
Deal found 6/2![United Airlines logo]()
$251
This American Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/116:00 am
MCI
- MYR
1 stop7h 48m
American Airlines
Fri 7/174:43 pm
MYR
- MCI
1 stop8h 40m
American Airlines
Deal found 6/5![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/192:10 pm
MCI
- CLT
1 stop6h 45m
Delta
Sun 6/218:01 am
CLT
- MCI
1 stop5h 14m
Delta
Deal found 6/3![Delta logo]()
$207
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/14:00 pm
STL
- CHS
1 stop4h 25m
Southwest
Tue 7/71:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Deal found 6/2![Southwest logo]()
$242
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2510:25 am
MCI
- MYR
1 stop6h 42m
Delta
Sat 8/296:00 am
MYR
- MCI
1 stop5h 15m
Delta
Deal found 6/1![Delta logo]()
$260
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/33:40 pm
STL
- CLT
Nonstop1h 50m
Southwest
Tue 7/710:40 am
CLT
- STL
2 stops8h 45m
Southwest
Deal found 6/1![Southwest logo]()
$275
This United Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am
MCI
- SAV
1 stop8h 04m
United Airlines
Wed 9/24:59 pm
SAV
- MCI
1 stop5h 46m
United Airlines
Deal found 6/1![United Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/33:57 pm
STL
- CLT
1 stop4h 01m
Delta
Tue 7/75:30 am
CLT
- STL
1 stop5h 13m
Delta
Deal found 6/2![Delta logo]()
$286
This United Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:00 am
STL
- CLT
1 stop5h 54m
United Airlines
Sat 8/298:05 am
CLT
- STL
1 stop4h 58m
United Airlines
Deal found 6/5![United Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/294:45 pm
STL
- SAV
Nonstop1h 55m
Southwest
Wed 8/56:45 am
SAV
- STL
2 stops9h 25m
Southwest
Deal found 6/6![Southwest logo]()
$292
This Delta deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:05 pm
STL
- CLT
1 stop3h 48m
Delta
Sat 11/77:05 pm
CLT
- STL
1 stop5h 34m
Delta
Deal found 6/4![Delta logo]()
$290
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:00 am
STL
- SAV
2 stops8h 08m
American Airlines
Sat 8/223:40 pm
SAV
- STL
1 stop4h 19m
American Airlines
Deal found 6/6![American Airlines logo]()
$390
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/223:10 pm
STL
- CHS
1 stop4h 20m
Southwest
Fri 7/3110:35 am
CHS
- STL
2 stops8h 55m
Southwest
Deal found 6/3![Southwest logo]()
$297
This United Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/112:59 pm
STL
- CHS
1 stop7h 35m
United Airlines
Wed 9/211:40 am
CHS
- STL
1 stop4h 58m
United Airlines
Deal found 6/2![United Airlines logo]()
$327
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:05 am
STL
- MYR
1 stop6h 45m
Southwest
Mon 8/176:40 am
MYR
- STL
1 stop5h 55m
Southwest
Deal found 6/5![Southwest logo]()
$299
This American Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:19 pm
COU
- CLT
1 stop6h 34m
American Airlines
Tue 7/78:40 pm
CLT
- COU
Nonstop2h 12m
American Airlines
Deal found 6/5![American Airlines logo]()
$407
This United Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:11 pm
MCI
- MYR
2 stops13h 33m
United Airlines
Mon 8/3110:23 am
MYR
- MCI
2 stops12h 22m
United Airlines
Deal found 6/1![United Airlines logo]()
$347
This Delta deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1311:00 am
STL
- CHS
1 stop4h 00m
Delta
Sun 8/165:10 am
CHS
- STL
1 stop4h 00m
Delta
Deal found 6/5![Delta logo]()
$318
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/41:40 pm
STL
- SAV
1 stop4h 35m
Southwest
Wed 8/1210:50 am
SAV
- STL
1 stop6h 35m
Southwest
Deal found 6/5![Southwest logo]()
$313
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:00 am
STL
- SAV
1 stop6h 10m
Delta
Sun 9/67:00 am
SAV
- STL
1 stop5h 56m
Delta
Deal found 6/3![Delta logo]()
$341
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:15 am
STL
- CHS
1 stop7h 50m
Southwest
Tue 8/46:45 am
CHS
- STL
2 stops9h 05m
Southwest
Deal found 6/5![Southwest logo]()
$313
This United Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/115:45 pm
MCI
- CLT
1 stop5h 14m
United Airlines
Sun 7/128:05 am
CLT
- MCI
1 stop7h 15m
United Airlines
Deal found 6/1![United Airlines logo]()
$380
This American Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2011:06 am
SGF
- CLT
Nonstop2h 14m
American Airlines
Tue 11/249:00 am
CLT
- SGF
Nonstop2h 34m
American Airlines
Deal found 6/5![American Airlines logo]()
$490
This United Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:00 am
STL
- MYR
1 stop5h 53m
United Airlines
Wed 9/210:23 am
MYR
- STL
2 stops12h 37m
United Airlines
Deal found 6/2![United Airlines logo]()
$384
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/173:45 pm
STL
- CLT
1 stop5h 05m
Southwest
Thu 9/246:35 am
CLT
- STL
2 stops8h 10m
Southwest
Deal found 6/3![Southwest logo]()
$319
This Delta deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:39 pm
STL
- MYR
1 stop5h 11m
Delta
Tue 7/76:00 am
MYR
- STL
1 stop4h 43m
Delta
Deal found 6/5![Delta logo]()
$365
This United Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:05 am
MCI
- SAV
1 stop7h 03m
United Airlines
Tue 7/78:00 am
SAV
- MCI
1 stop5h 22m
United Airlines
Deal found 6/1![United Airlines logo]()
$391
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:25 am
STL
- CLT
2 stops8h 25m
Southwest
Wed 7/2210:40 am
CLT
- STL
2 stops8h 40m
Southwest
Deal found 6/1![Southwest logo]()
$325
Last-minute flights from Missouri to South CarolinaDiscover last-minute flight deals from Missouri to South Carolina. Data last updated June 6, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South Carolina. Data last updated June 6, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:25 am
MCI
- CLT
1 stop5h 01m
Delta
Wed 6/176:59 am
CLT
- MCI
1 stop6h 16m
Delta
Deal found 6/3![Delta logo]()
$221
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/205:38 am
MCI
- CLT
1 stop6h 57m
Delta
Sun 6/218:01 am
CLT
- MCI
1 stop5h 14m
Delta
Deal found 6/3![Delta logo]()
$187
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:00 am
STL
- CLT
1 stop6h 35m
Delta
Tue 6/306:00 am
CLT
- STL
1 stop4h 46m
Delta
Deal found 6/2![Delta logo]()
$237
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/303:38 pm
MCI
- CLT
1 stop4h 20m
Delta
Wed 7/16:00 am
CLT
- MCI
1 stop4h 48m
Delta
Deal found 6/2![Delta logo]()
$247
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:40 am
STL
- CLT
1 stop4h 30m
Southwest
Wed 7/81:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/3![Southwest logo]()
$227
This Southwest deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/13:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Wed 7/81:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Deal found 6/3![Southwest logo]()
$237
This CheapOair deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:45 pm
MCI
- CLT
1 stop6h 40m
Frontier
Wed 7/810:04 pm
CLT
- MCI
1 stop15h 56m
Frontier
Deal found 6/2![Frontier logo]()
$240
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/14:00 pm
STL
- CHS
1 stop4h 25m
Southwest
Tue 7/71:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Deal found 6/2![Southwest logo]()
$242
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:12 pm
STL
- CHS
1 stop4h 24m
Delta
Tue 7/75:10 am
CHS
- STL
1 stop5h 33m
Delta
Deal found 6/2![Delta logo]()
$247
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/23:38 pm
MCI
- CLT
1 stop7h 21m
Delta
Mon 7/65:30 am
CLT
- MCI
1 stop5h 01m
Delta
Deal found 6/3![Delta logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/84:09 pm
STL
- CHS
1 stop15h 29m
Multiple Airlines
Wed 7/154:04 pm
CHS
- STL
1 stop8h 55m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$239
This American Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:12 pm
STL
- CLT
Nonstop2h 03m
American Airlines
Wed 7/2910:56 pm
CLT
- STL
Nonstop2h 02m
American Airlines
Deal found 6/4![American Airlines logo]()
$217
One-way flights from Missouri to South CarolinaSearch for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 6, 2026.
Search for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 6, 2026.
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:54 am
STL
- CHS
1 stop5h 22m
American Airlines
Deal found 6/1![American Airlines logo]()
$89
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2010:33 am
MCI
- CLT
1 stop5h 21m
Delta
Deal found 6/3![Delta logo]()
$94
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:00 am
STL
- CHS
1 stop5h 11m
Delta
Deal found 6/1![Delta logo]()
$96
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:31 pm
STL
- CLT
2 stops26h 04m
Frontier
Deal found 6/2![Frontier logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/14:10 pm
STL
- CHS
1 stop15h 58m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/304:17 pm
STL
- CHS
1 stop15h 51m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/24:10 pm
STL
- CHS
1 stop15h 28m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$100
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:38 am
MCI
- CLT
1 stop4h 54m
Delta
Deal found 6/2![Delta logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/13:33 pm
STL
- CLT
2 stops43h 32m
Frontier
Deal found 6/3![Frontier logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/314:10 pm
STL
- CHS
1 stop15h 28m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$105
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/294:50 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 6/1![Southwest logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/14:17 pm
STL
- CHS
1 stop15h 21m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$110
Find flight deals from Missouri to South Carolina
Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated June 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $187 (Delta) |
One-way from | $89 (American Airlines) |
Popular in | April |
Cheapest in | February |
Average price | $364 |
Good round-trip deal | $336 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 6, 2026.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Kansas CityCharlotte
MCI - CLT
MCICLT
Kansas City
Thu 7/9
2:10 pm-9:57 pm
1 stop6h 47m
Charlotte Douglas
Sun 7/12
5:30 am-9:38 am
1 stop5h 08m
$187
Kansas CityCharlotte
MCI - CLT
MCICLT
Kansas City
Fri 6/19
2:10 pm-9:55 pm
1 stop6h 45m
Charlotte Douglas
Sun 6/21
8:01 am-12:15 pm
1 stop5h 14m
$207
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 7/1
5:40 am-2:35 pm
2 stops7h 55m
Charlotte Douglas
Wed 7/8
8:15 pm-11:05 pm
1 stop3h 50m
$242
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Wed 7/1
4:00 pm-9:25 pm
1 stop4h 25m
Charleston
Tue 7/7
1:50 pm-3:00 pm
Nonstop2h 10m
$242
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 9/5
7:25 am-1:56 pm
1 stop5h 31m
Charlotte Douglas
Mon 9/7
8:05 am-12:02 pm
1 stop4h 57m
$251
Kansas CityMyrtle Beach
MCI - MYR
MCIMYR
Kansas City
Tue 8/25
10:25 am-6:07 pm
1 stop6h 42m
Myrtle Beach Intl
Sat 8/29
6:00 am-10:15 am
1 stop5h 15m
$260
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Fri 7/3
3:40 pm-6:30 pm
Nonstop1h 50m
Charlotte Douglas
Tue 7/7
10:40 am-6:25 pm
2 stops8h 45m
$275
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Fri 7/3
3:57 pm-8:58 pm
1 stop4h 01m
Charlotte Douglas
Tue 7/7
5:30 am-9:43 am
1 stop5h 13m
$286
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Fri 10/30
7:05 pm-11:53 pm
1 stop3h 48m
Charlotte Douglas
Sat 11/7
7:05 pm-11:39 pm
1 stop5h 34m
$290
St. LouisSavannah
STL - SAV
STLSAV
Lambert-St Louis
Wed 7/29
4:45 pm-7:40 pm
Nonstop1h 55m
Savannah/Hilton Head
Wed 8/5
6:45 am-3:10 pm
2 stops9h 25m
$292
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
MCI-CLT
STL-CLT
STL-MYR
STL-CHS
MCI-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South Carolina
USMO-USSC
MCI-CLT
STL-CLT
STL-MYR
STL-CHS
What is the cheapest month to book a flight from Missouri to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $89). Flying from Missouri to South Carolina in January is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SC?
Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 6, 2026.
When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from Missouri to South Carolina?
How far ahead should I book a flight from Missouri to South Carolina?
The price you pay for your flight from Missouri to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 87 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated June 6, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Food
7.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Food
7.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Food
7.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Food
7.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Food
7.0
Boarding
8.1
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South Carolina by cabin class
Find flights from Missouri to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South Carolina flights
Browse other Missouri and South Carolina flight options. Last updated on June 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Missouri after your stay in South Carolina
Missouri to South Carolina flights
Consider these flights traveling from Missouri to South Carolina.
Top 4 airlines flying from Missouri to South Carolina
Discover the top 4 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$146 | Average$375 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$193 | Average$403 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$391 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$237 | Average$435 | FlexibilityNo cancel fee | On-time63% |