HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$54+ Cheap flights from Missouri to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/11. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
jul. 6 — jul. 131
dom. 7/6
dom. 7/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to South Carolina

Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated julio 1, 2025.

Round-trip from

$163
(FlightHub)

One-way from

$54
(FlightHub)

Popular in

March

Cheapest in

September

Average price

$396

Good round-trip deal

$397 or less
From Missouri to South Carolina
Search Deals
One-way flight from Missouri to South Carolina
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($33 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals
Price to beat on a round-trip flight from Missouri to South Carolina.
Search Deals

Find flight deals from Missouri to South Carolina

Cheapest flights from Missouri to South Carolina
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 1, 2025.

This FlightHub deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 8/182:30 pmSTL - MYR
1 stop4h 23mSpirit Airlines
sáb. 8/235:20 pmMYR - STL
1 stop21h 12mSpirit Airlines
Deal found 6/30$163
This Cheapflightsfares deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 7/224:23 pmMCI - MYR
1 stop4h 54mSpirit Airlines
mar. 7/296:10 amMYR - MCI
1 stop10h 07mSpirit Airlines
Deal found 7/1$177
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/37:30 amSTL - MYR
1 stop6h 57mAmerican Airlines
jue. 8/75:23 amMYR - STL
1 stop3h 41mAmerican Airlines
Deal found 6/30$187
This Priceline deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/210:45 amSTL - CLT
1 stop8h 48mMultiple Airlines
mar. 8/57:03 pmCLT - STL
1 stop5h 44mMultiple Airlines
Deal found 7/1$194
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/315:23 pmSTL - MYR
1 stop5h 36mDelta
jue. 8/77:50 pmMYR - STL
1 stop5h 03mDelta
Deal found 7/1$197
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/273:10 pmSTL - CLT
Nonstop1h 50mSouthwest
jue. 9/47:50 pmCLT - STL
Nonstop2h 00mSouthwest
Deal found 7/1$197
This FlightHub deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/142:30 pmSTL - CLT
1 stop21h 40mSpirit Airlines
dom. 8/172:14 pmCLT - STL
1 stop24h 18mSpirit Airlines
Deal found 6/30$199
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/31:40 pmSTL - MYR
Nonstop1h 55mSouthwest
jue. 8/76:00 pmMYR - STL
1 stop5h 35mSouthwest
Deal found 6/30$207
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/216:49 pmSTL - CHS
1 stop4h 02mDelta
jue. 8/286:20 amCHS - STL
1 stop3h 55mDelta
Deal found 6/30$207
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 8/126:40 amSTL - CLT
1 stop4h 20mDelta
jue. 8/147:05 amCLT - STL
1 stop3h 52mDelta
Deal found 6/30$217
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/1310:45 amSTL - CHS
2 stops8h 25mSouthwest
mié. 8/278:35 amCHS - STL
1 stop5h 10mSouthwest
Deal found 6/30$222
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/26:42 pmMCI - MYR
1 stop3h 54mDelta
mar. 12/1611:10 amMYR - MCI
1 stop7h 07mDelta
Deal found 6/29$227

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 1, 2025.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.

Fly from

Missouri

Fly to

South Carolina

Route

Depart

Return

Price

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

lun. 8/18

2:30 pm-7:53 pm

1 stop4h 23m

Myrtle Beach Intl

sáb. 8/23

5:20 pm-1:32 pm

1 stop21h 12m

$163

Kansas CityMyrtle Beach

MCI - MYR

MCIMYR

Kansas City

mar. 7/22

4:23 pm-10:17 pm

1 stop4h 54m

Myrtle Beach Intl

mar. 7/29

6:10 am-3:17 pm

1 stop10h 07m

$177

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

dom. 8/3

7:30 am-3:27 pm

1 stop6h 57m

Myrtle Beach Intl

jue. 8/7

5:23 am-8:04 am

1 stop3h 41m

$187

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

sáb. 8/2

10:45 am-8:33 pm

1 stop8h 48m

Charlotte Douglas

mar. 8/5

7:03 pm-11:47 pm

1 stop5h 44m

$194

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

jue. 7/31

5:23 pm-11:59 pm

1 stop5h 36m

Myrtle Beach Intl

jue. 8/7

7:50 pm-11:53 pm

1 stop5h 03m

$197

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

mié. 8/27

3:10 pm-6:00 pm

Nonstop1h 50m

Charlotte Douglas

jue. 9/4

7:50 pm-8:50 pm

Nonstop2h 00m

$197

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

jue. 8/14

2:30 pm-1:10 pm

1 stop21h 40m

Charlotte Douglas

dom. 8/17

2:14 pm-1:32 pm

1 stop24h 18m

$199

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

dom. 8/3

1:40 pm-4:35 pm

Nonstop1h 55m

Myrtle Beach Intl

jue. 8/7

6:00 pm-10:35 pm

1 stop5h 35m

$207

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

jue. 8/21

6:49 pm-11:51 pm

1 stop4h 02m

Charleston

jue. 8/28

6:20 am-9:15 am

1 stop3h 55m

$207

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

mar. 8/12

6:40 am-12:00 pm

1 stop4h 20m

Charlotte Douglas

jue. 8/14

7:05 am-9:57 am

1 stop3h 52m

$217

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Missouri to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South Carolina

What is the cheapest month to book a flight from Missouri to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SC?

Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 1, 2025.

When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated julio 1, 2025.
See what other customers who have flown with Alaska Airlines, Southwest, and Delta from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Food

7.1

Crew

8.5

Entertainment

7.1

Overall

8.0

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Food

7.1

Crew

8.5

Entertainment

7.1

Overall

8.0

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Southwest
8.0
Very good
4,273 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Food

7.1

Crew

8.5

Entertainment

7.1

Overall

8.0

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,973 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Food

7.1

Crew

8.5

Entertainment

7.1

Overall

8.0

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,858 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Food

7.1

Crew

8.5

Entertainment

7.1

Overall

8.0

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Food

7.1

Crew

8.5

Entertainment

7.1

Overall

8.0

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Missouri to South Carolina flight route?

    The Missouri to South Carolina flight path was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Missouri to South Carolina one-way?

    For one-way options, check prices for Spirit Airlines. According to our data, you can fly for as low as $54. Users have also found prices from $89 and $94 on Southwest and American Airlines, respectively.

  • Can I find deals for flights from Missouri to South Carolina that include hotel bookings?

    Yes. In addition to deals on Missouri to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South Carolina.

  • Can I find deals for business class flights from Missouri to South Carolina?

    Yes. Cheapflights offers flight deals from Missouri to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Dallas/Fort Worth to Seattle flights
Dallas/Fort Worth to LaGuardia flights
Los Angeles to John F Kennedy Intl flights
Los Angeles to Seattle flights
John F Kennedy Intl to Los Angeles flights
Dallas/Fort Worth to John F Kennedy Intl flights
Dallas/Fort Worth to O'Hare Intl flights
Atlanta to John F Kennedy Intl flights
John F Kennedy Intl to Orlando flights
John F Kennedy Intl to O'Hare Intl flights
John F Kennedy Intl to Las Vegas flights
Dallas/Fort Worth to Los Angeles flights
John F Kennedy Intl to Atlanta flights
Los Angeles to Newark flights
LaGuardia to Dallas/Fort Worth flights
Newark to Miami flights
John F Kennedy Intl to Miami flights
Newark to Los Angeles flights
Newark to Fort Lauderdale flights
Newark to O'Hare Intl flights
John F Kennedy Intl to Seattle flights
Dallas/Fort Worth to Las Vegas flights
San Francisco to John F Kennedy Intl flights
Los Angeles to Honolulu flights
LaGuardia to Atlanta flights
LaGuardia to Fort Lauderdale flights
Atlanta to LaGuardia flights
John F Kennedy Intl to San Francisco flights
Los Angeles to Dallas/Fort Worth flights
LaGuardia to Miami flights
Newark to Seattle flights
Newark to Atlanta flights
O'Hare Intl to John F Kennedy Intl flights
Seattle to Los Angeles flights
San Francisco to Las Vegas flights
LaGuardia to O'Hare Intl flights
O'Hare Intl to LaGuardia flights
O'Hare Intl to Las Vegas flights
San Francisco to Los Angeles flights
John F Kennedy Intl to Dallas/Fort Worth flights
Dallas/Fort Worth to Newark flights
Dallas/Fort Worth to Orlando flights
O'Hare Intl to Dallas/Fort Worth flights
Los Angeles to San Francisco flights
San Francisco to Newark flights
Ontario to Seattle flights
John F Kennedy Intl to Denver flights
O'Hare Intl to Newark flights
Atlanta to Las Vegas flights
Atlanta to Newark flights

Top 5 airlines flying from Missouri to South Carolina

Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$112Average$217FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$164Average$413FlexibilityNo cancel feeOn-time71%
DeltaCheapest$196Average$373FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$223Average$430FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$276Average$401FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.