$68+ Cheap flights from St. Louis to San Diego (STL - SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/6. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAN
Nov 24 — Dec 11
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from St. Louis to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Lambert-St Louis to San Diego are usually found in July or May, booked 70 days in advance, depart on a Saturday or Sunday and return on a Wednesday
Cheap flight deals from St. Louis to San Diego
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to San DiegoExplore the most affordable flight options available from St. Louis to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from St. Louis to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This CheapOair deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:59 pm -
1 stop5h 58m
Wed 11/116:25 am -
1 stop6h 58m
Deal found 10/23![Frontier logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:34 pm -
2 stops31h 23m
Mon 11/238:50 am -
1 stop29h 30m
Deal found 10/21![Frontier logo]()
$309
This Travelocity deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1010:25 am -
1 stop8h 06m
Fri 12/186:36 am -
1 stop6h 50m
Deal found 10/21![Multiple Airlines logo]()
$310
This Expedia deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/214:21 pm -
1 stop9h 37m
Mon 12/286:36 am -
1 stop6h 50m
Deal found 10/20![Frontier logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/114:18 pm -
1 stop9h 39m
Mon 11/308:50 am -
2 stops33h 17m
Deal found 10/20![Frontier logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/114:18 pm -
1 stop9h 39m
Sun 11/221:02 pm -
2 stops40h 52m
Deal found 10/21![Frontier logo]()
$313
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/65:40 am -
1 stop6h 00m
Wed 12/911:55 am -
Nonstop3h 30m
Deal found 10/20![Southwest logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:59 pm -
1 stop5h 58m
Fri 11/208:50 am -
1 stop29h 30m
Deal found 10/21![Frontier logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/91:28 pm -
1 stop8h 07m
Sun 11/226:30 am -
1 stop26h 33m
Deal found 10/21![Frontier logo]()
$316
This Mytrip deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:13 pm -
2 stops19h 24m
Fri 12/49:05 am -
2 stops23h 52m
Deal found 10/22![Frontier logo]()
$317
This Cheapflightsfares deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/51:28 pm -
1 stop8h 07m
Wed 12/212:32 pm -
1 stop22h 35m
Deal found 10/24![Frontier logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:59 pm -
1 stop5h 58m
Sun 11/159:32 am -
1 stop23h 47m
Deal found 10/21![Frontier logo]()
$319
Best flights from St. Louis to San DiegoDiscover carefully curated flight deals from St. Louis to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from St. Louis to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:03 am -
2 stops10h 48m
Wed 12/91:36 pm -
1 stop5h 52m
Deal found 10/21![Delta logo]()
$361
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/138:30 am -
Nonstop4h 00m
Mon 1/186:35 am -
1 stop5h 45m
Deal found 10/22![Southwest logo]()
$387
This Alaska Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:00 am -
2 stops15h 47m
Sat 11/211:36 pm -
1 stop8h 23m
Deal found 10/22![Alaska Airlines logo]()
$446
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:00 am -
2 stops10h 55m
Thu 11/269:39 pm -
2 stops12h 34m
Deal found 10/24![United Airlines logo]()
$449
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/92:21 pm -
1 stop9h 49m
Mon 11/309:50 pm -
1 stop9h 11m
Deal found 10/20![Delta logo]()
$378
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1012:40 pm -
2 stops6h 45m
Mon 11/235:20 pm -
1 stop5h 15m
Deal found 10/22![Southwest logo]()
$392
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:45 am -
1 stop6h 25m
Mon 11/306:15 pm -
1 stop5h 30m
Deal found 10/21![Southwest logo]()
$403
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:03 am -
1 stop8h 59m
Tue 12/157:20 am -
2 stops12h 08m
Deal found 10/21![Delta logo]()
$411
This Southwest deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:25 am -
Nonstop3h 55m
Sat 11/1411:55 am -
1 stop6h 05m
Deal found 10/24![Southwest logo]()
$433
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/225:16 pm -
1 stop8h 34m
Sat 1/26:25 am -
1 stop6h 19m
Deal found 10/20![Delta logo]()
$451
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/198:25 am -
Nonstop3h 55m
Thu 11/266:35 am -
1 stop8h 20m
Deal found 10/22![Southwest logo]()
$435
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/68:30 am -
Nonstop4h 00m
Wed 12/911:55 am -
Nonstop3h 30m
Deal found 10/20![Southwest logo]()
$447
Last-minute flights from St. Louis to San DiegoDiscover last-minute flight deals from St. Louis to San Diego. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to San Diego. Data last updated October 25, 2026 and is based on user searches.
This Cheapflightsfares deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/51:28 pm -
1 stop8h 07m
Wed 12/212:32 pm -
1 stop22h 35m
Deal found 10/24![Frontier logo]()
$318
This Cheapflightsfares deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/51:28 pm -
1 stop8h 07m
Mon 11/96:25 am -
1 stop10h 49m
Deal found 10/21![Frontier logo]()
$322
This CheapOair deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:59 pm -
1 stop5h 58m
Wed 11/116:25 am -
1 stop6h 58m
Deal found 10/23![Frontier logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:59 pm -
1 stop5h 58m
Fri 11/208:50 am -
1 stop29h 30m
Deal found 10/21![Frontier logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:34 pm -
2 stops31h 23m
Mon 11/238:50 am -
1 stop29h 30m
Deal found 10/21![Frontier logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/91:28 pm -
1 stop8h 07m
Sun 11/226:30 am -
1 stop26h 33m
Deal found 10/21![Frontier logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/114:18 pm -
1 stop9h 39m
Mon 11/308:50 am -
2 stops33h 17m
Deal found 10/20![Frontier logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/114:18 pm -
1 stop9h 39m
Sun 11/221:02 pm -
2 stops40h 52m
Deal found 10/21![Frontier logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:59 pm -
1 stop5h 58m
Sun 11/159:32 am -
1 stop23h 47m
Deal found 10/21![Frontier logo]()
$319
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/182:54 pm -
1 stop8h 56m
Sat 11/213:15 pm -
1 stop6h 20m
Deal found 10/22![American Airlines logo]()
$321
One-way flights from St. Louis to San DiegoSearch for one-way flight options from St. Louis to San Diego. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from St. Louis to San Diego. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/66:20 pm -
1 stop24h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/24![Frontier logo]()
$68
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:54 pm -
1 stop6h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Frontier logo]()
$104
This Cheapflightsfares deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:59 pm -
1 stop5h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Frontier logo]()
$106
This Priceline deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/167:59 pm -
1 stop5h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Frontier logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:04 pm -
1 stop10h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Frontier logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/184:18 pm -
1 stop9h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Frontier logo]()
$110
This Cheapflightsfares deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:58 pm -
1 stop16h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Frontier logo]()
$111
This Super.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:59 pm -
1 stop21h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Frontier logo]()
$112
This Cheapflightsfares deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:15 pm -
1 stop16h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Frontier logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:20 pm -
2 stops41h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/24![Frontier logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/233:04 pm -
1 stop10h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Frontier logo]()
$120
Find flight deals from St. Louis to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $308 (CheapOair) |
One-way from | $68 (Cheapflightsfares) |
Popular in | January |
Cheapest in | July |
Average price | $432 |
Good round-trip deal | $493 or less |
Good one-way deal | $172 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from St. Louis to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Wed 11/18
4:18 pm-10:11 am
2 stops19h 53m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$123
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Thu 12/10
6:25 am-9:55 am
1 stop5h 30m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$137
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Thu 12/17
6:09 pm-10:32 pm
1 stop6h 23m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$142
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Thu 10/29
10:12 am-2:17 pm
1 stop6h 05m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$153
Quickest round-trip
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Sat 11/14
3:05 pm-5:00 pm
Nonstop3h 55m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$167
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Fri 11/27
6:15 am-10:59 am
1 stop6h 44m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$180
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Fri 11/20
7:05 pm-12:19 am
1 stop7h 14m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$180
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Tue 12/8
6:25 am-9:55 am
1 stop5h 30m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$184
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Thu 10/29
1:28 pm-7:47 pm
1 stop8h 19m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$216
St. LouisSan Diego
STL Lambert-St Louis - SAN San Diego
STLSAN
Lambert-St Louis
Fri 12/4
8:25 am-10:20 am
Nonstop3h 55m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$268
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from St. Louis to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to San Diego in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from St. Louis with our price prediction graph.
STL-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to San Diego
Prices
More
How far ahead should I book a flight from St. Louis to San Diego?
To ensure you get the cheapest price possible for a flight from St. Louis to San Diego, you should look to book at least 69 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from St. Louis to San Diego?
Currently, July is the cheapest month in which you can book a flight from St. Louis to San Diego (average of $371). Flying from St. Louis to San Diego in January is currently the most expensive (average of $442). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to SAN?
Find hourly flight availability from St. Louis to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 25, 2026.
Unlike at noon, when flights are generally more expensive, you can save up to 19% on flights from St. Louis to San Diego by exploring options for tickets in the afternoon.
What’s the top layover airport for flights from St. Louis to San Diego?
Share of 1-stop round-trip flights from St. Louis to San Diego chosen by Cheapflights users in the past 12 months, using the same layover each way.
Salt Lake City (SLC) – chosen by Cheapflights users on 33% of 1-stop itineraries from St. Louis to San Diego on Cheapflights.
What’s the cheapest layover airport for flights from St. Louis to San Diego?
Average round-trip fare for 1-stop flights from St. Louis to San Diego, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Las Vegas (LAS) is the most affordable 1-stop option, with an average round-trip price of $176.
What’s the fastest layover option from St. Louis to San Diego?
Shortest average travel time for 1-stop one-way flights from St. Louis to San Diego, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 5h 41m.
Which airport typically offers the quickest layover for flights from St. Louis to San Diego?
Average layover duration for 1-stop one-way flights from St. Louis to San Diego, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Salt Lake City (SLC) offer the fastest connection on this route, with an average layover time of 0h 53m.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated October 25, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from St. Louis to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Boarding
8.1
Entertainment
7.4
Overall
7.9
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentWalter,Aug 2025
OAK - SAN
Food
7.0
Boarding
8.1
Entertainment
7.4
Overall
7.9
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentWalter,Aug 2025
OAK - SAN
Food
7.0
Boarding
8.1
Entertainment
7.4
Overall
7.9
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentWalter,Aug 2025
OAK - SAN
Food
7.0
Boarding
8.1
Entertainment
7.4
Overall
7.9
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentWalter,Aug 2025
OAK - SAN
Food
7.0
Boarding
8.1
Entertainment
7.4
Overall
7.9
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentWalter,Aug 2025
OAK - SAN
Food
7.0
Boarding
8.1
Entertainment
7.4
Overall
7.9
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentWalter,Aug 2025
OAK - SAN
Related info for your journey
Find useful and relevant information for your journey from St. Louis to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
San Ysidro
Poway
Coronado
La Mesa
Julian
Santee
Lemon Grove
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from St. Louis
Popular flights
San Diego flight routes
Alternative routes for St. Louis to San Diego
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Diego by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to San Diego by cabin class
Find flights from St. Louis to San Diego, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and San Diego flights
Browse other St. Louis and San Diego flight options. Last updated on October 25, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Top 6 airlines flying from St. Louis to San Diego
Discover the top 6 airlines that operate flights from St. Louis to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$151 | Average$283 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$222 | Average$316 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$236 | Average$336 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$236 | Average$389 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$266 | Average$488 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$294 | Average$463 | FlexibilityNo cancel fee | On-time63% |