$74+ Cheap flights from St. Louis to San Diego (STL - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAN
May 23 — May 301
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Lambert-St Louis to San Diego are usually found in October or September, booked 64 days in advance, depart on a Wednesday or Tuesday and return on a Thursday
Cheap flight deals from St. Louis to San Diego
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Last-minute
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Cheapest flights from St. Louis to San DiegoExplore the most affordable flight options available from St. Louis to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
Explore the most affordable flight options available from St. Louis to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
This Gotogate deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:51 pm
STL
- SAN
1 stop28h 13m
Frontier
Sun 5/176:25 am
SAN
- STL
1 stop10h 58m
Frontier
Deal found 4/23![Frontier logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:51 pm
STL
- SAN
1 stop28h 21m
Frontier
Tue 5/2610:07 pm
SAN
- STL
2 stops19h 16m
Frontier
Deal found 4/22![Frontier logo]()
$246
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:20 am
STL
- SAN
1 stop6h 49m
American Airlines
Wed 5/133:09 pm
SAN
- STL
1 stop6h 47m
American Airlines
Deal found 4/23![American Airlines logo]()
$247
This Expedia deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/238:08 pm
STL
- SAN
1 stop5h 45m
Frontier
Sat 6/276:25 am
SAN
- STL
1 stop10h 09m
Frontier
Deal found 4/19![Frontier logo]()
$250
This Expedia deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/49:55 pm
STL
- SAN
1 stop22h 44m
Frontier
Fri 5/86:25 am
SAN
- STL
1 stop10h 58m
Frontier
Deal found 4/22![Frontier logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:08 pm
STL
- SAN
2 stops18h 35m
Frontier
Fri 5/296:25 am
SAN
- STL
1 stop10h 58m
Frontier
Deal found 4/19![Frontier logo]()
$252
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/112:50 pm
STL
- SAN
2 stops7h 40m
Southwest
Fri 8/143:20 pm
SAN
- STL
1 stop6h 30m
Southwest
Deal found 4/20![Southwest logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:51 pm
STL
- SAN
1 stop28h 21m
Frontier
Sun 5/246:25 am
SAN
- STL
2 stops24h 30m
Frontier
Deal found 4/22![Frontier logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/68:16 pm
STL
- SAN
2 stops38h 26m
Frontier
Tue 6/99:53 pm
SAN
- STL
1 stop18h 15m
Frontier
Deal found 4/20![Frontier logo]()
$256
This Expedia deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:55 pm
STL
- SAN
1 stop21h 57m
Frontier
Mon 4/276:25 am
SAN
- STL
1 stop6h 11m
Frontier
Deal found 4/19![Frontier logo]()
$260
This CheapOair deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/89:06 pm
STL
- SAN
1 stop25h 52m
Frontier
Sun 6/146:25 am
SAN
- STL
1 stop10h 58m
Frontier
Deal found 4/20![Frontier logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/143:33 pm
STL
- SAN
2 stops34h 17m
Frontier
Mon 5/189:59 pm
SAN
- STL
1 stop18h 07m
Frontier
Deal found 4/22![Frontier logo]()
$262
Best flights from St. Louis to San DiegoDiscover carefully curated flight deals from St. Louis to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
Discover carefully curated flight deals from St. Louis to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/245:10 am
STL
- SAN
1 stop5h 55m
United Airlines
Sun 9/2710:30 pm
SAN
- STL
1 stop8h 07m
United Airlines
Deal found 4/21![United Airlines logo]()
$291
This Alaska Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:59 pm
STL
- SAN
1 stop18h 06m
Alaska Airlines
Sun 9/138:03 pm
SAN
- STL
1 stop19h 00m
Alaska Airlines
Deal found 4/22![Alaska Airlines logo]()
$304
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:00 am
STL
- SAN
Nonstop4h 00m
Southwest
Tue 6/97:05 am
SAN
- STL
Nonstop3h 40m
Southwest
Deal found 4/23![Southwest logo]()
$320
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:21 am
STL
- SAN
1 stop6h 16m
Delta
Wed 6/37:10 pm
SAN
- STL
2 stops11h 36m
Delta
Deal found 4/22![Delta logo]()
$441
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:59 pm
STL
- SAN
1 stop6h 17m
United Airlines
Sat 5/1610:55 am
SAN
- STL
2 stops8h 18m
United Airlines
Deal found 4/23![United Airlines logo]()
$321
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:40 pm
STL
- SAN
1 stop5h 15m
Southwest
Sun 8/232:50 pm
SAN
- STL
2 stops7h 15m
Southwest
Deal found 4/20![Southwest logo]()
$380
This Alaska Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:51 am
STL
- SAN
1 stop7h 39m
Alaska Airlines
Wed 5/137:15 am
SAN
- STL
2 stops13h 04m
Alaska Airlines
Deal found 4/23![Alaska Airlines logo]()
$412
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:45 am
STL
- SAN
1 stop9h 48m
United Airlines
Sat 5/98:54 am
SAN
- STL
2 stops11h 51m
United Airlines
Deal found 4/20![United Airlines logo]()
$402
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/711:35 am
STL
- SAN
1 stop6h 20m
Southwest
Sat 5/162:50 pm
SAN
- STL
Nonstop3h 30m
Southwest
Deal found 4/23![Southwest logo]()
$436
This Alaska Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/22:38 pm
STL
- SAN
1 stop7h 45m
Alaska Airlines
Sat 7/46:18 am
SAN
- STL
2 stops15h 41m
Alaska Airlines
Deal found 4/20![Alaska Airlines logo]()
$444
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:15 pm
STL
- SAN
2 stops7h 15m
Southwest
Sat 5/98:40 am
SAN
- STL
2 stops7h 25m
Southwest
Deal found 4/22![Southwest logo]()
$489
Last-minute flights from St. Louis to San DiegoDiscover last-minute flight deals from St. Louis to San Diego. Data last updated April 23, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to San Diego. Data last updated April 23, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:55 pm
STL
- SAN
1 stop21h 57m
Frontier
Mon 4/276:25 am
SAN
- STL
1 stop6h 11m
Frontier
Deal found 4/19![Frontier logo]()
$260
This Frontier deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/273:21 pm
STL
- SAN
1 stop8h 23m
Frontier
Thu 4/306:25 am
SAN
- STL
1 stop10h 56m
Frontier
Deal found 4/21![Frontier logo]()
$261
This Expedia deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/49:55 pm
STL
- SAN
1 stop22h 44m
Frontier
Fri 5/86:25 am
SAN
- STL
1 stop10h 58m
Frontier
Deal found 4/22![Frontier logo]()
$251
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/68:54 am
STL
- SAN
1 stop7h 24m
American Airlines
Mon 5/111:18 pm
SAN
- STL
1 stop7h 01m
American Airlines
Deal found 4/20![American Airlines logo]()
$266
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:20 am
STL
- SAN
1 stop6h 49m
American Airlines
Wed 5/133:09 pm
SAN
- STL
1 stop6h 47m
American Airlines
Deal found 4/23![American Airlines logo]()
$247
This Gotogate deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:51 pm
STL
- SAN
1 stop28h 13m
Frontier
Sun 5/176:25 am
SAN
- STL
1 stop10h 58m
Frontier
Deal found 4/23![Frontier logo]()
$245
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/132:12 pm
STL
- SAN
1 stop8h 38m
American Airlines
Sun 5/1710:40 pm
SAN
- STL
1 stop7h 47m
American Airlines
Deal found 4/21![American Airlines logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/144:19 pm
STL
- SAN
2 stops33h 31m
Frontier
Mon 5/189:59 pm
SAN
- STL
1 stop18h 07m
Frontier
Deal found 4/23![Frontier logo]()
$262
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:51 pm
STL
- SAN
1 stop28h 21m
Frontier
Tue 5/2610:07 pm
SAN
- STL
2 stops19h 16m
Frontier
Deal found 4/22![Frontier logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:51 pm
STL
- SAN
1 stop28h 21m
Frontier
Sun 5/246:25 am
SAN
- STL
2 stops24h 30m
Frontier
Deal found 4/22![Frontier logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:08 pm
STL
- SAN
2 stops18h 35m
Frontier
Fri 5/296:25 am
SAN
- STL
1 stop10h 58m
Frontier
Deal found 4/19![Frontier logo]()
$252
This Expedia deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:08 pm
STL
- SAN
1 stop5h 42m
Frontier
Sun 5/319:37 am
SAN
- STL
1 stop7h 46m
Frontier
Deal found 4/20![Frontier logo]()
$250
One-way flights from St. Louis to San DiegoSearch for one-way flight options from St. Louis to San Diego. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
Search for one-way flight options from St. Louis to San Diego. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:19 pm
STL
- SAN
1 stop25h 31m
Frontier
Deal found 4/22![Frontier logo]()
$74
This Super.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/159:18 pm
STL
- SAN
1 stop25h 46m
Frontier
Deal found 4/23![Frontier logo]()
$85
This CheapOair deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/189:18 pm
STL
- SAN
1 stop25h 46m
Frontier
Deal found 4/19![Frontier logo]()
$92
This Frontier deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/238:08 pm
STL
- SAN
1 stop5h 45m
Frontier
Deal found 4/20![Frontier logo]()
$105
This Expedia deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/89:18 pm
STL
- SAN
1 stop25h 51m
Frontier
Deal found 4/22![Frontier logo]()
$106
This Trip.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:51 pm
STL
- SAN
1 stop25h 48m
Frontier
Deal found 4/21![Frontier logo]()
$109
This Priceline deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:36 pm
STL
- SAN
1 stop10h 33m
Frontier
Deal found 4/20![Frontier logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/263:33 pm
STL
- SAN
2 stops25h 58m
Frontier
Deal found 4/20![Frontier logo]()
$113
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:51 pm
STL
- SAN
2 stops22h 40m
Frontier
Deal found 4/20![Frontier logo]()
$116
Find flight deals from St. Louis to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $245 (Gotogate) |
One-way from | $74 (Kiwi.com) |
Popular in | December |
Cheapest in | October |
Average price | $418 |
Good round-trip deal | $482 or less |
Good one-way deal | $371 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from St. Louis to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSan Diego
STL - SAN
STLSAN
Lambert-St Louis
Thu 9/24
5:10 am-9:05 am
1 stop5h 55m
San Diego
Sun 9/27
10:30 pm-8:37 am
1 stop8h 07m
$291
St. LouisSan Diego
STL - SAN
STLSAN
Lambert-St Louis
Fri 9/11
5:59 pm-10:05 am
1 stop18h 06m
San Diego
Sun 9/13
8:03 pm-5:03 pm
1 stop19h 00m
$304
Quickest round-trip
St. LouisSan Diego
STL - SAN
STLSAN
Lambert-St Louis
Sat 5/30
7:00 am-9:00 am
Nonstop4h 00m
San Diego
Tue 6/9
7:05 am-12:45 pm
Nonstop3h 40m
$320
St. LouisSan Diego
STL - SAN
STLSAN
Lambert-St Louis
Thu 5/7
5:59 pm-10:16 pm
1 stop6h 17m
San Diego
Sat 5/16
10:55 am-9:13 pm
2 stops8h 18m
$321
St. LouisSan Diego
STL - SAN
STLSAN
Lambert-St Louis
Thu 8/20
6:40 pm-9:55 pm
1 stop5h 15m
San Diego
Sun 8/23
2:50 pm-12:05 am
2 stops7h 15m
$380
St. LouisSan Diego
STL - SAN
STLSAN
Lambert-St Louis
Thu 5/7
7:45 am-3:33 pm
1 stop9h 48m
San Diego
Sat 5/9
8:54 am-10:45 pm
2 stops11h 51m
$402
St. LouisSan Diego
STL - SAN
STLSAN
Lambert-St Louis
Sun 5/10
5:51 am-11:30 am
1 stop7h 39m
San Diego
Wed 5/13
7:15 am-10:19 pm
2 stops13h 04m
$412
St. LouisSan Diego
STL - SAN
STLSAN
Lambert-St Louis
Thu 5/7
11:35 am-3:55 pm
1 stop6h 20m
San Diego
Sat 5/16
2:50 pm-8:20 pm
Nonstop3h 30m
$436
St. LouisSan Diego
STL - SAN
STLSAN
Lambert-St Louis
Sun 5/31
6:21 am-10:37 am
1 stop6h 16m
San Diego
Wed 6/3
7:10 pm-8:46 am
2 stops11h 36m
$441
St. LouisSan Diego
STL - SAN
STLSAN
Lambert-St Louis
Thu 7/2
2:38 pm-8:23 pm
1 stop7h 45m
San Diego
Sat 7/4
6:18 am-11:59 pm
2 stops15h 41m
$444
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from St. Louis to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to San Diego in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from St. Louis with our price prediction graph.
STL-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to San Diego
Prices
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How far ahead should I book a flight from St. Louis to San Diego?
To ensure you get the cheapest price possible for a flight from St. Louis to San Diego, you should look to book at least 63 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from St. Louis to San Diego?
Currently, October is the cheapest month in which you can book a flight from St. Louis to San Diego (average of $331). Flying from St. Louis to San Diego in December is currently the most expensive (average of $458). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from STL to SAN?
Find hourly flight availability from St. Louis to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 23, 2026.
Unlike at noon, when flights are generally more expensive, you can save up to 24% on flights from St. Louis to San Diego by exploring options for tickets in the afternoon.
What’s the top layover airport for flights from St. Louis to San Diego?
Share of 1-stop round-trip flights from St. Louis to San Diego chosen by Cheapflights users in the past 12 months, using the same layover each way.
Salt Lake City (SLC) – chosen by Cheapflights users on 50% of 1-stop itineraries from St. Louis to San Diego on Cheapflights.
What’s the cheapest layover airport for flights from St. Louis to San Diego?
Average round-trip fare for 1-stop flights from St. Louis to San Diego, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Denver (DEN) is the most affordable 1-stop option, with an average round-trip price of $312.
What’s the fastest layover option from St. Louis to San Diego?
Shortest average travel time for 1-stop one-way flights from St. Louis to San Diego, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Salt Lake City (SLC) have the shortest average one-way travel time for 1-stop routes: 6h 19m.
Which airport typically offers the quickest layover for flights from St. Louis to San Diego?
Average layover duration for 1-stop one-way flights from St. Louis to San Diego, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Salt Lake City (SLC) offer the fastest connection on this route, with an average layover time of 0h 53m.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated April 23, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from St. Louis to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from St. Louis to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove
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St. Louis and San Diego flights
Browse other St. Louis and San Diego flight options. Last updated on April 23, 2026.
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Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on April 23, 2026.
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Top 5 airlines flying from St. Louis to San Diego
Discover the top 5 airlines that operate flights from St. Louis to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$88 | Average$233 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$136 | Average$326 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$182 | Average$328 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$226 | Average$369 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$285 | Average$457 | FlexibilityNo cancel fee | On-time63% |