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St. Louis

$43+ Cheap flights from San Diego to St. Louis (SAN - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/4. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — STL
Jul 5 — Jul 121
Sat 7/5
Sat 7/12
1 adult, Economy
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Cheapflights Tip: The best prices from San Diego to Lambert-St Louis are usually found in August or February, booked 81 days in advance, depart on a Wednesday or Thursday and return on a Tuesday

Cheap flight deals from San Diego to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 30, 2025.

Round-trip from

$128
(Priceline)

One-way from

$43
(Priceline)

Popular in

December

Cheapest in

August

Average price

$404

Good round-trip deal

$414 or less

Good one-way deal

$218 or less
From San Diego to Lambert-St Louis
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One-way flight from San Diego to Lambert-St Louis
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Highest demand for flights based on searches. 5% potential increase in price ($23 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Price to beat on a round-trip flight from San Diego to Lambert-St Louis.
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Price to beat on a one-way flight from San Diego to Lambert-St Louis.
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Find flight deals from San Diego to St. Louis

Cheapest flights from San Diego to St. Louis
Explore the most affordable flight options available from San Diego to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 30, 2025.

This Priceline deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/56:25 amSAN - STL
1 stop5h 28mFrontier
Sun 9/77:55 pmSTL - SAN
1 stop5h 58mFrontier
Deal found 6/30$128
This Mytrip deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/217:01 pmSAN - STL
2 stops16h 31mSpirit Airlines
Sun 8/242:30 pmSTL - SAN
3 stops29h 26mSpirit Airlines
Deal found 6/28$262
This FlightHub deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1511:21 amSAN - STL
1 stop19h 50mMultiple Airlines
Sun 8/172:30 pmSTL - SAN
1 stop22h 37mMultiple Airlines
Deal found 6/28$281
This Alaska Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/48:21 amSAN - STL
2 stops13h 38mAlaska Airlines
Tue 9/93:35 pmSTL - SAN
1 stop10h 18mAlaska Airlines
Deal found 6/28$298
This Southwest deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1610:15 amSAN - STL
Nonstop3h 45mSouthwest
Tue 9/234:45 pmSTL - SAN
Nonstop3h 45mSouthwest
Deal found 6/29$313

Cheapflights Fare Finder

Customize your flight search to find flights from San Diego to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 30, 2025.
Use the filters below to find and compare flights from San Diego to St. Louis that are best for you.

Fly from

San Diego

Fly to

St. Louis

Route

Depart

Return

Price

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Fri 9/5

6:25 am-1:53 pm

1 stop5h 28m

Lambert-St Louis

Sun 9/7

7:55 pm-11:53 pm

1 stop5h 58m

$128

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 8/21

7:01 pm-1:32 pm

2 stops16h 31m

Lambert-St Louis

Sun 8/24

2:30 pm-5:56 pm

3 stops29h 26m

$262

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Fri 8/15

11:21 am-9:11 am

1 stop19h 50m

Lambert-St Louis

Sun 8/17

2:30 pm-11:07 am

1 stop22h 37m

$281

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 9/4

8:21 am-11:59 pm

2 stops13h 38m

Lambert-St Louis

Tue 9/9

3:35 pm-11:53 pm

1 stop10h 18m

$298

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Tue 9/16

10:15 am-4:00 pm

Nonstop3h 45m

Lambert-St Louis

Tue 9/23

4:45 pm-6:30 pm

Nonstop3h 45m

$313

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Sat 8/9

10:30 pm-8:06 am

1 stop7h 36m

Lambert-St Louis

Tue 8/12

6:06 am-2:07 pm

1 stop10h 01m

$328

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 9/4

6:25 am-1:53 pm

1 stop5h 28m

$43

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Wed 8/6

3:57 pm-9:52 am

2 stops15h 55m

$111

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Tue 10/28

2:47 pm-3:05 pm

2 stops22h 18m

$147

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/28

The best insider tips for San Diego to St. Louis flights

Snippets provided in this section are AI-generated based on a summarization of Cheapflights-commissioned articles. The articles are presented as-is, for general informational purposes only, and may not be up-to-date. The opinions contained in the articles are original to the author and reflect their authentic experience, which may vary significantly from the experience of others.
Cheapflights partnered with top experts to bring you the best recommendations for your San Diego to St. Louis trip
Airports
SAN

Plan to arrive at SAN at least two hours before your flight to avoid stress from traffic congestion near the airport.

Read more about SANby Blane Bachelor
STL

Use the MetroLink light rail for a convenient and economical way to reach downtown St. Louis from STL.

Read more about STLby Taryn White
Our travel experts
Blane Bachelor

Blane Bachelor

Expert on SAN

Blane Bachelor

Blane Bachelor

Blane Bachelor is a journalist and editor specializing in travel and aviation who writes regularly for top global outlets. Born and raised in Florida, Blane has worked and lived in four countries, including the Netherlands, where she’s currently based with her family. Her favorite way to get to know a new destination is by running or riding a bike around town – or hearing a spooky ghost story about local history. She will always choose the window seat.

Read more
Taryn White

Taryn White

Expert on STL

Taryn White

Taryn White

Taryn White is a freelance travel writer, digital creator, and travel advisor who has visited nearly 100 countries and all 50 states. She’s familiar with many airports and enjoys beach hopping, boutique hotels, spa experiences, and exploring local culture. Her work has appeared in Travel + Leisure, Condé Nast Traveler, National Geographic, Smithsonian Magazine, AFAR, and more.

Read more

Best time to book a flight from San Diego to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to St. Louis

How far ahead should I book a flight from San Diego to St. Louis?

Use this chart to determine the optimal time to book a round-trip flight from San Diego to St. Louis. Price data was last updated on June 27, 2025.

The best time to book flights from San Diego to St. Louis is 80 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from San Diego to St. Louis?

Currently, August is the cheapest month in which you can book a flight from San Diego to St. Louis (average of $311). Flying from San Diego to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to STL?

Find hourly flight availability from San Diego to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 30, 2025.

A simple way to save on the total cost of your ticket is to fly from San Diego to St. Louis in the evening. If you’re flexible enough to do this you can expect to save up to 65% on your trip compared to booking a flight at noon.

What is the cheapest day to fly from San Diego to St. Louis?

Use this chart to determine the cheapest time to fly round-trip from San Diego to St. Louis. Price data was last updated on June 29, 2025.

Travelers seeking maximum savings on their San Diego to St. Louis flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated June 30, 2025.
Peruse reviews from past customers who have flown with Alaska Airlines, Southwest, and American Airlines from San Diego to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Comfort

7.8

Entertainment

7.1

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Comfort

7.8

Entertainment

7.1

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Southwest
8.0
Very good
4,278 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Comfort

7.8

Entertainment

7.1

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Comfort

7.8

Entertainment

7.1

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Spirit Airlines
6.3
Okay
8,094 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Comfort

7.8

Entertainment

7.1

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Frontier
5.9
Fair
3,290 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Food

7.1

Overall

8.0

Comfort

7.8

Entertainment

7.1

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from San Diego to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from San Diego to St. Louis?

    To fly from San Diego to St. Louis, you need to book a flight from San Diego (SAN) to Lambert-St Louis (STL). Nonstop flights to Lambert-St Louis from San Diego take 3h 30m on average. When it comes time to book airfare, you have a few options: there is 1 outbound flight from San Diego to Lambert-St Louis offered by 5 different airlines.

  • How popular is this San Diego to St. Louis flight route?

    Flights from San Diego to Lambert-St Louis have been viewed 8 times in the past calendar month.

  • What are the cheapest airlines flying from San Diego to St. Louis round-trip?

    Cheapflights users have booked flights from San Diego to St. Louis round-trip from $128. Other airlines that can offer you cheap pricing are Spirit Airlines, from $262, and Alaska Airlines, from $298. Frontier is priced at 65% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from San Diego to St. Louis one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $43. Users have also found prices from $111 and $147 on Spirit Airlines and Alaska Airlines, respectively.

  • What are the cheapest flights from San Diego to St. Louis?

    Looking for the cheapest flight from San Diego to St. Louis? While on average our users pay $323, our data indicates the cheapest price to be $72. The most popular route (San Diego - Lambert-St Louis), is priced around $247.

  • Where are the most common layover locations when flying from San Diego to St. Louis?

    Of the flights from San Diego to St. Louis that have layovers, most of them stop in Phoenix.

  • What are some popular things to do or see while on a layover in Phoenix?

    Chase Field, Desert Ridge Marketplace, and Phoenix Symphony Hall are currently the most popular points of interest in Phoenix at the moment. Those on a layover in Phoenix interested in visiting Chase Field, Desert Ridge Marketplace, or Phoenix Symphony Hall can do so by traveling 4.0 mi, 16.7 mi, and 4.3 mi, respectively from Phoenix Sky Harbor Intl. Travelers can book a car rental at Phoenix Sky Harbor Intl for about $50 per day to make their sightseeing more efficient.

  • Where are the least popular layover locations for San Diego to St. Louis flights?

    San Diego to St. Louis flights have a layover in Denver the least frequently.

  • Can I find deals for flights from San Diego to St. Louis that include hotel bookings?

    Yes. In addition to deals on San Diego to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to St. Louis.

  • Can I find deals for business class flights from San Diego to St. Louis?

    Yes. Cheapflights offers flight deals from San Diego to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from San Diego to St. Louis (average of $311). Flying from San Diego to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
O'Fallon
Maryland Heights
Fairview Heights
Collinsville
Eureka
St. Peters
Glencoe
Alton
Festus
Chesterfield
Farmington

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Top 5 airlines flying from San Diego to St. Louis

Discover the top 5 airlines that operate flights from San Diego to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$113Average$285FlexibilityNo cancel feeOn-time62%
DeltaCheapest$184Average$276FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$246Average$340FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$256Average$345FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$343Average$488FlexibilityNo cancel feeOn-time63%

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