What are the cheapest airlines flying from Santa Ana to St. Louis round-trip?

Frontier, at $222, was found to be the cheapest airline from Santa Ana to St. Louis.Alternate airlines to your destination round-trip include Spirit Airlines and Delta. Frontier is priced at 52% lower than the current average price of a flight leaving 3 months from now.

What are the cheapest airlines to fly from Santa Ana to St. Louis one-way?

The cheapest airlines for a one-way flight from Santa Ana to St. Louis are Frontier ($114), United Airlines ($135), and Alaska Airlines ($136).

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the most popular airlines that fly from Santa Ana to St. Louis?

Consider American Airlines, Delta or Frontier when booking your flight. These represent the most popular airlines when flying from Santa Ana to St. Louis.

What is the cheapest day to fly round-trip from Santa Ana to St. Louis?

Leaving on a Monday is a viable option for saving on travel. Heavily demanded days of the week can typically drive up the prices you see. Booking your travel for a less competitive day can save up to 31% on the overall cost on flights from Santa Ana to St. Louis.

How far in advance should I book a flight from Santa Ana to St. Louis?

Find a great deal and save up to 278% by booking at least 61 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from Santa Ana to St. Louis within the next two weeks, with the cheapest ticket starting at $375.

What is the cheapest month to fly from Santa Ana to St. Louis?

August can be a great time to fly to St. Louis from Santa Ana with a flight ticket averaging about $400. Cheapflights users have found deals in the month of August for as cheap as $182. The most expensive prices can be found in the month of December.

Can I find deals for flights from Santa Ana to St. Louis that include hotel bookings?

Yes. In addition to deals on Santa Ana to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santa Ana to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to St. Louis.

Can I find deals for business class flights from Santa Ana to St. Louis?

Yes. Cheapflights offers flight deals from Santa Ana to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$114+ Flights from Santa Ana to St. Louis

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Cheapflights Tip: The best prices from Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis are usually found in May or October, booked 50 days in advance, depart on a Tuesday or Friday and return on a Wednesday

Cheap flight deals from Santa Ana to St. Louis

Round-trip from	$222 (FlightHub)
One-way from	$114 (Mytrip)
Popular in	January
Cheapest in	May
Average price	$458

From Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis

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One-way flight from Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis

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Highest demand for flights based on searches. 6% potential increase in price ($35 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Santa Ana to St. Louis

Cheapest flights from Santa Ana to St. Louis
Explore the most affordable flight options available from Santa Ana to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 2, 2025.

mar. 9/912:58 pmSNA - STL

1 stop18h 08mFrontier

jue. 9/187:55 pmSTL - SNA

1 stop17h 12mFrontier

Deal found 6/30

$222

mié. 9/2412:33 pmSNA - STL

1 stop23h 02mSpirit Airlines

dom. 9/282:30 pmSTL - SNA

1 stop23h 08mSpirit Airlines

Deal found 7/2

$239

jue. 8/284:37 pmSNA - STL

1 stop19h 09mMultiple Airlines

lun. 9/12:30 pmSTL - SNA

1 stop22h 59mMultiple Airlines

Deal found 6/30

$258

jue. 7/315:05 pmSNA - STL

1 stop5h 33mDelta

jue. 8/73:41 pmSTL - SNA

1 stop8h 22mDelta

Deal found 7/1

$279

lun. 8/113:10 pmSNA - STL

1 stop6h 15mSouthwest

vie. 8/159:50 amSTL - SNA

2 stops6h 40mSouthwest

Deal found 6/30

$284

mar. 10/2111:38 amSNA - STL

1 stop6h 48mAmerican Airlines

jue. 11/206:01 amSTL - SNA

1 stop6h 34mAmerican Airlines

Deal found 6/30

$315

mié. 9/241:08 pmSNA - STL

2 stops23h 33mAlaska Airlines

dom. 9/286:30 pmSTL - SNA

1 stop17h 19mAlaska Airlines

Deal found 6/30

$354

Best flights from Santa Ana to St. Louis
Discover carefully curated flight deals from Santa Ana to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated julio 2, 2025.

mar. 9/912:58 pmSNA - STL

1 stop18h 08mFrontier

jue. 9/187:55 pmSTL - SNA

1 stop17h 12mFrontier

Deal found 6/30

$222

mié. 9/2412:33 pmSNA - STL

1 stop23h 02mSpirit Airlines

dom. 9/282:30 pmSTL - SNA

1 stop23h 08mSpirit Airlines

Deal found 7/2

$239

jue. 8/284:37 pmSNA - STL

1 stop19h 09mMultiple Airlines

lun. 9/12:30 pmSTL - SNA

1 stop22h 59mMultiple Airlines

Deal found 6/30

$258

jue. 7/315:05 pmSNA - STL

1 stop5h 33mDelta

jue. 8/73:41 pmSTL - SNA

1 stop8h 22mDelta

Deal found 7/1

$279

lun. 8/113:10 pmSNA - STL

1 stop6h 15mSouthwest

vie. 8/159:50 amSTL - SNA

2 stops6h 40mSouthwest

Deal found 6/30

$284

mar. 10/2111:38 amSNA - STL

1 stop6h 48mAmerican Airlines

jue. 11/206:01 amSTL - SNA

1 stop6h 34mAmerican Airlines

Deal found 6/30

$315

mié. 9/241:08 pmSNA - STL

2 stops23h 33mAlaska Airlines

dom. 9/286:30 pmSTL - SNA

1 stop17h 19mAlaska Airlines

Deal found 6/30

$354

Last-minute flights from Santa Ana to St. Louis
Discover last-minute flight deals from Santa Ana to St. Louis. Data last updated julio 2, 2025 and is based on user searches.

lun. 7/77:40 pmSNA - STL

3 stops35h 10mMultiple Airlines

mié. 7/911:24 amSTL - SNA

2 stops26h 02mMultiple Airlines

Deal found 7/1

$476

lun. 7/71:15 pmSNA - STL

1 stop6h 35mUnited Airlines

lun. 7/146:00 amSTL - SNA

1 stop7h 10mUnited Airlines

Deal found 6/30

$711

lun. 7/77:14 pmSNA - STL

1 stop17h 12mAlaska Airlines

mié. 7/93:24 pmSTL - SNA

1 stop9h 06mAlaska Airlines

Deal found 7/1

$862

mié. 7/98:00 amSNA - STL

1 stop6h 42mDelta

dom. 7/137:45 amSTL - SNA

1 stop6h 15mDelta

Deal found 6/30

$801

mié. 7/97:00 amSNA - STL

2 stops9h 25mSouthwest

dom. 7/1310:05 amSTL - SNA

2 stops8h 35mSouthwest

Deal found 6/30

$811

jue. 7/103:37 pmSNA - STL

2 stops16h 15mSpirit Airlines

dom. 7/1310:47 amSTL - SNA

3 stops29h 55mSpirit Airlines

Deal found 7/2

$663

vie. 7/113:32 pmSNA - STL

2 stops15h 39mFrontier

dom. 7/137:54 pmSTL - SNA

2 stops17h 16mFrontier

Deal found 7/1

$522

jue. 7/173:32 pmSNA - STL

1 stop20h 10mFrontier

lun. 7/212:37 pmSTL - SNA

1 stop6h 03mFrontier

Deal found 7/2

$303

mié. 7/3010:59 amSNA - STL

2 stops11h 00mAlaska Airlines

mar. 8/123:24 pmSTL - SNA

1 stop8h 15mAlaska Airlines

Deal found 7/2

$404

jue. 7/315:05 pmSNA - STL

1 stop5h 33mDelta

jue. 8/73:41 pmSTL - SNA

1 stop8h 22mDelta

Deal found 7/1

$279

jue. 7/317:58 pmSNA - STL

2 stops11h 54mSpirit Airlines

jue. 8/710:47 amSTL - SNA

2 stops26h 39mSpirit Airlines

Deal found 7/1

$341

mar. 8/58:51 amSNA - STL

2 stops11h 54mUnited Airlines

mar. 8/125:31 pmSTL - SNA

1 stop6h 46mUnited Airlines

Deal found 7/2

$430

One-way flights from Santa Ana to St. Louis
Search for one-way flight options from Santa Ana to St. Louis. Find affordable one-way fares based on user searches. Data last updated julio 2, 2025.

jue. 9/1811:52 amSNA - STL

1 stop19h 14mFrontier

Deal found 7/2

$114

mar. 9/307:06 amSNA - STL

1 stop7h 39mUnited Airlines

Deal found 7/1

$135

jue. 10/3012:35 pmSNA - STL

1 stop9h 23mAlaska Airlines

Deal found 7/1

$136

jue. 7/315:05 pmSNA - STL

1 stop5h 33mDelta

Deal found 7/2

$140

sáb. 8/168:30 pmSNA - STL

2 stops15h 02mSpirit Airlines

Deal found 6/30

$144

mar. 9/308:55 amSNA - STL

2 stops6h 55mSouthwest

Deal found 7/1

$145

mar. 9/308:40 pmSNA - STL

3 stops13h 30mMultiple Airlines

Deal found 7/1

$182

mar. 12/237:58 pmSNA - STL

2 stops11h 28mAmerican Airlines

Deal found 7/2

$274

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santa Ana to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

mié. 9/24

12:33 pm-1:35 pm

1 stop23h 02m

Lambert-St Louis

dom. 9/28

2:30 pm-11:38 am

1 stop23h 08m

$239

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

jue. 8/28

4:37 pm-1:46 pm

1 stop19h 09m

Lambert-St Louis

lun. 9/1

2:30 pm-11:29 am

1 stop22h 59m

$258

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

jue. 7/31

5:05 pm-12:38 am

1 stop5h 33m

Lambert-St Louis

jue. 8/7

3:41 pm-10:03 pm

1 stop8h 22m

$279

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

lun. 8/11

3:10 pm-11:25 pm

1 stop6h 15m

Lambert-St Louis

vie. 8/15

9:50 am-2:30 pm

2 stops6h 40m

$284

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

jue. 7/17

3:32 pm-1:42 pm

1 stop20h 10m

Lambert-St Louis

lun. 7/21

2:37 pm-6:40 pm

1 stop6h 03m

$303

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

vie. 9/5

7:30 am-4:53 pm

1 stop7h 23m

Lambert-St Louis

dom. 9/7

6:15 am-11:05 am

1 stop6h 50m

$314

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

mar. 10/21

10:23 am-8:26 pm

1 stop8h 03m

Lambert-St Louis

jue. 11/20

6:01 am-10:35 am

1 stop6h 34m

$315

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

mar. 9/23

6:45 am-5:34 pm

1 stop8h 49m

Lambert-St Louis

jue. 9/25

3:35 pm-10:30 pm

1 stop8h 55m

$318

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

jue. 9/18

11:52 am-9:06 am

1 stop19h 14m

$114

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

mar. 9/30

7:06 am-4:45 pm

1 stop7h 39m

$135

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/2

Showing 1-10 of 16 results

Best time to book a flight from Santa Ana to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santa Ana with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to St. Louis

How far ahead should I book a flight from Santa Ana to St. Louis?

The price you pay for your flight from Santa Ana to St. Louis may vary depending on when you book. For the best chance of a lower fare, look to book 50 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santa Ana to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Santa Ana to St. Louis (average of $311). Flying from Santa Ana to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SNA to STL?

It’s optimal to fly from Santa Ana to St. Louis in the evening. By choosing this option you can save up to 23% on the cost of your flight, compared to a flight at noon.

What is the cheapest day to fly from Santa Ana to St. Louis?

Travelers seeking maximum savings on their Santa Ana to St. Louis flight should consider departing on Sunday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing St. Louis

Read reviews from past customers who have flown Alaska Airlines, Southwest, and Delta from Santa Ana to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Alaska Airlines

8.0

Very good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Alaska Airlines

8.0

Very good

10,000 reviews

Alaska Airlines

8.0

Very good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Southwest

8.0

Very good

4,272 reviews

Alaska Airlines

8.0

Very good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Delta

8.0

Very good

7,983 reviews

Alaska Airlines

8.0

Very good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

United Airlines

7.4

Good

8,861 reviews

Alaska Airlines

8.0

Very good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

American Airlines

7.2

Good

10,000 reviews

Alaska Airlines

8.0

Very good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

What are the cheapest airlines flying from Santa Ana to St. Louis round-trip?
Frontier, at $222, was found to be the cheapest airline from Santa Ana to St. Louis.Alternate airlines to your destination round-trip include Spirit Airlines and Delta. Frontier is priced at 52% lower than the current average price of a flight leaving 3 months from now.
What are the cheapest airlines to fly from Santa Ana to St. Louis one-way?
The cheapest airlines for a one-way flight from Santa Ana to St. Louis are Frontier ($114), United Airlines ($135), and Alaska Airlines ($136).
Can I find deals for flights from Santa Ana to St. Louis that include hotel bookings?
Yes. In addition to deals on Santa Ana to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santa Ana to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to St. Louis.
Can I find deals for business class flights from Santa Ana to St. Louis?
Yes. Cheapflights offers flight deals from Santa Ana to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santa Ana to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Santa Ana to St. Louis (average of $311). Flying from Santa Ana to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

O'Fallon

Maryland Heights

Fairview Heights

Collinsville

Eureka

St. Peters

Glencoe

Alton

Festus

Chesterfield

Farmington

Browse thousands of different options on Cheapflights for your next trip

Top 5 airlines flying from Santa Ana to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$138	Average$239	FlexibilityNo cancel fee	On-time62%
American Airlines	Cheapest$342	Average$461	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$346	Average$490	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$352	Average$474	FlexibilityNo cancel fee	On-time69%
Southwest	Cheapest$366	Average$487	FlexibilityNo cancel fee	On-time63%

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$114+ Cheap flights from Santa Ana to St. Louis (SNA - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/18. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santa Ana to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis are usually found in May or October, booked 50 days in advance, depart on a Tuesday or Friday and return on a Wednesday

Cheap flight deals from Santa Ana to St. Louis

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Santa Ana to St. Louis

Cheapest flights from Santa Ana to St. LouisExplore the most affordable flight options available from Santa Ana to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 2, 2025.

Explore the most affordable flight options available from Santa Ana to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 2, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santa Ana to St. Louis that are best for you.

Best time to book a flight from Santa Ana to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santa Ana with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to St. Louis

How far ahead should I book a flight from Santa Ana to St. Louis?

Use this chart to determine the optimal time to book a round-trip flight from Santa Ana to St. Louis. Price data was last updated on June 27, 2025.

What is the cheapest month to book a flight from Santa Ana to St. Louis?

What is the cheapest time of day to fly from SNA to STL?

Find hourly flight availability from Santa Ana to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 2, 2025.

What is the cheapest day to fly from Santa Ana to St. Louis?

Use this chart to determine the cheapest time to fly round-trip from Santa Ana to St. Louis. Price data was last updated on December 16, 2024.

Reviews of airlines servicing St. Louis

Read reviews from past customers who have flown Alaska Airlines, Southwest, and Delta from Santa Ana to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Santa Ana to St. Louis round-trip?

What are the cheapest airlines to fly from Santa Ana to St. Louis one-way?

Can I find deals for flights from Santa Ana to St. Louis that include hotel bookings?

How can I find direct flights from Santa Ana to St. Louis?

Can I find deals for business class flights from Santa Ana to St. Louis?

What is the cheapest month to book a flight from Santa Ana to St. Louis?

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Alternative routes for Santa Ana to St. Louis

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Top 5 airlines flying from Santa Ana to St. Louis

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Cheapest flights from Santa Ana to St. Louis
Explore the most affordable flight options available from Santa Ana to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 2, 2025.