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$349+ Cheap flights from Medford to St. Louis (MFR - STL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
MFR — STL
May 28 — Jun 41
Thu 5/28
Thu 6/4
1 adult, Economy
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Cheap flight deals from Medford to St. Louis

Cheapest flights from Medford to St. Louis
Explore the most affordable flight options available from Medford to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.

This Orbitz deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/512:00 pm
MFR
-
STL
1 stop9h 59m
Alaska Airlines
Tue 10/67:00 am
STL
-
MFR
1 stop7h 52m
Alaska Airlines
Deal found 4/27$349
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:20 am
MFR
-
STL
1 stop6h 16m
Delta
Tue 6/162:28 pm
STL
-
MFR
2 stops10h 44m
Delta
Deal found 4/26$354
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/91:40 pm
MFR
-
STL
1 stop5h 26m
Delta
Wed 5/137:59 pm
STL
-
MFR
1 stop5h 43m
Delta
Deal found 4/23$399
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:15 am
MFR
-
STL
2 stops12h 54m
Delta
Mon 6/157:52 pm
STL
-
MFR
1 stop6h 05m
Delta
Deal found 4/24$417
This Expedia deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:41 pm
MFR
-
STL
1 stop19h 35m
Alaska Airlines
Tue 5/266:00 am
STL
-
MFR
1 stop8h 49m
Alaska Airlines
Deal found 4/26$419
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:15 am
MFR
-
STL
1 stop6h 17m
Delta
Wed 6/101:59 pm
STL
-
MFR
2 stops11h 58m
Delta
Deal found 4/26$434

Find flight deals from Medford to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Medford (MFR) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$349
(Orbitz)

Popular in

December

Cheapest in

August

Average price

$395
Provider with most accurate pricing for Medford-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Medford-Lambert-St Louis flights.
Search Deals
From Medford to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($201 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($45 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Medford to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
Use the filters below to find and compare flights from Medford to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MedfordSt. Louis

MFR - STL

MFRSTL

Medford

Mon 10/5

12:00 pm-11:59 pm

1 stop9h 59m

Lambert-St Louis

Tue 10/6

7:00 am-12:52 pm

1 stop7h 52m

$349

MedfordSt. Louis

MFR - STL

MFRSTL

Medford

Thu 6/11

5:20 am-1:36 pm

1 stop6h 16m

Lambert-St Louis

Tue 6/16

2:28 pm-11:12 pm

2 stops10h 44m

$354

MedfordSt. Louis

MFR - STL

MFRSTL

Medford

Sat 5/9

5:15 am-5:16 pm

2 stops10h 01m

Lambert-St Louis

Wed 5/13

7:59 pm-11:42 pm

1 stop5h 43m

$404

MedfordSt. Louis

MFR - STL

MFRSTL

Medford

Sat 5/30

5:15 am-1:32 pm

1 stop6h 17m

Lambert-St Louis

Wed 6/10

1:59 pm-11:57 pm

2 stops11h 58m

$434

MedfordSt. Louis

MFR - STL

MFRSTL

Medford

Sat 5/30

5:00 am-3:46 pm

2 stops8h 46m

Lambert-St Louis

Wed 6/10

5:10 am-12:04 pm

2 stops8h 54m

$457

MedfordSt. Louis

MFR - STL

MFRSTL

Medford

Wed 6/10

1:10 pm-8:43 pm

1 stop5h 33m

Lambert-St Louis

Mon 6/15

5:10 am-12:04 pm

2 stops8h 54m

$458

MedfordSt. Louis

MFR - STL

MFRSTL

Medford

Mon 10/5

1:08 pm-11:45 pm

1 stop8h 37m

Lambert-St Louis

Tue 10/6

5:10 am-11:34 am

2 stops8h 24m

$463
Quickest round-trip

MedfordSt. Louis

MFR - STL

MFRSTL

Medford

Thu 6/4

5:15 am-1:32 pm

1 stop6h 17m

Lambert-St Louis

Mon 6/15

7:52 pm-11:57 pm

1 stop6h 05m

$494

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/27

Sorted by cheapest first

Compare providers for flights from Medford to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Medford to St. Louis in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Medford-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Medford-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Medford-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Medford-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Medford-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Medford to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Medford with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Medford to St. Louis

How much does it cost to fly round-trip from Medford to St. Louis?

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated April 28, 2026.
Peruse reviews from past customers who have flown with Delta and United Airlines from Medford to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,467 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,467 reviews
Delta
7.9
Good
8,467 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,672 reviews
Delta
7.9
Good
8,467 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Medford to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Medford to St. Louis?

    For as low as $354, Alaska Airlines can have you in St. Louis from Medford in 6h 16m. There are 1712 mi between Medford and St. Louis. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Medford to St. Louis round-trip?

    Cheapflights users have booked flights from Medford to St. Louis round-trip from $178. Another airline that can offer you cheap pricing is United Airlines. Delta is priced at 66% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Medford to St. Louis that include hotel bookings?

    Yes. In addition to deals on Medford to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Medford to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Medford to St. Louis.

  • Can I find deals for business class flights from Medford to St. Louis?

    Yes. Cheapflights offers flight deals from Medford to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Medford to St. Louis

Discover the top 2 airlines that operate flights from Medford to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$178Average$396FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$437Average$540FlexibilityNo cancel feeOn-time69%

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