$348+ Cheap flights from Columbia, MO to San Francisco (COU - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/4. Fares are subject to change and may not be available on all flights or dates of travel.
COU — SFO
Oct 8 — Oct 151
Round-trip
1 adult, Economy
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Find cheap flights from Columbia to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Columbia to San Francisco
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Best
Last-minute
One-way
Cheapest flights from Columbia to San FranciscoExplore the most affordable flight options available from Columbia to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
Explore the most affordable flight options available from Columbia to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:32 pm -
1 stop7h 49m
Sat 10/1011:36 pm -
1 stop8h 22m
Deal found 9/3![American Airlines logo]()
$348
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:51 pm -
1 stop8h 37m
Tue 9/227:00 am -
1 stop9h 02m
Deal found 9/3![American Airlines logo]()
$418
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:14 pm -
1 stop9h 30m
Sat 10/176:00 am -
1 stop9h 54m
Deal found 9/6![American Airlines logo]()
$448
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:51 pm -
1 stop8h 37m
Sun 9/2010:46 pm -
1 stop9h 10m
Deal found 9/5![American Airlines logo]()
$463
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:19 am -
1 stop9h 35m
Tue 10/65:00 am -
1 stop8h 08m
Deal found 9/6![United Airlines logo]()
$468
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:48 pm -
1 stop6h 59m
Tue 12/1510:34 am -
1 stop9h 41m
Deal found 9/4![American Airlines logo]()
$497
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/193:11 pm -
1 stop9h 48m
Wed 9/2310:35 pm -
1 stop10h 04m
Deal found 9/4![United Airlines logo]()
$518
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:26 pm -
1 stop8h 04m
Thu 10/811:36 pm -
1 stop8h 25m
Deal found 9/3![American Airlines logo]()
$534
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:47 am -
2 stops9h 12m
Thu 12/1011:39 pm -
1 stop8h 09m
Deal found 9/7![American Airlines logo]()
$540
Best flights from Columbia to San FranciscoDiscover carefully curated flight deals from Columbia to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
Discover carefully curated flight deals from Columbia to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:11 pm -
1 stop8h 14m
Thu 12/1010:34 am -
1 stop9h 41m
Deal found 9/7![American Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:19 am -
1 stop9h 35m
Tue 10/65:00 am -
1 stop8h 08m
Deal found 9/3![United Airlines logo]()
$448
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:32 pm -
1 stop7h 49m
Sat 10/1011:36 pm -
1 stop8h 22m
Deal found 9/3![American Airlines logo]()
$348
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:24 pm -
1 stop8h 06m
Wed 10/216:00 am -
1 stop9h 54m
Deal found 9/6![American Airlines logo]()
$448
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:00 am -
2 stops10h 30m
Wed 9/239:00 am -
1 stop9h 12m
Deal found 9/4![American Airlines logo]()
$486
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:48 pm -
1 stop6h 59m
Tue 12/1510:34 am -
1 stop9h 41m
Deal found 9/4![American Airlines logo]()
$497
Last-minute flights from Columbia to San FranciscoDiscover last-minute flight deals from Columbia to San Francisco. Data last updated September 8, 2026 and is based on user searches.
Discover last-minute flight deals from Columbia to San Francisco. Data last updated September 8, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:51 pm -
1 stop8h 37m
Tue 9/227:00 am -
1 stop9h 02m
Deal found 9/3![American Airlines logo]()
$418
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:51 pm -
1 stop8h 37m
Sun 9/2010:46 pm -
1 stop9h 10m
Deal found 9/5![American Airlines logo]()
$463
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/193:11 pm -
1 stop9h 48m
Wed 9/2310:35 pm -
1 stop10h 04m
Deal found 9/4![United Airlines logo]()
$518
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:26 pm -
1 stop8h 04m
Thu 10/811:36 pm -
1 stop8h 25m
Deal found 9/3![American Airlines logo]()
$534
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:32 pm -
1 stop7h 49m
Sat 10/1011:36 pm -
1 stop8h 22m
Deal found 9/3![American Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:19 am -
1 stop9h 35m
Tue 10/65:00 am -
1 stop8h 08m
Deal found 9/5![United Airlines logo]()
$468
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:14 pm -
1 stop7h 52m
Tue 10/209:12 am -
1 stop9h 43m
Deal found 9/6![American Airlines logo]()
$448
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1312:01 pm -
2 stops9h 02m
Sun 10/1811:36 pm -
1 stop8h 22m
Deal found 9/6![American Airlines logo]()
$551
One-way flights from Columbia to San FranciscoSearch for one-way flight options from Columbia to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
Search for one-way flight options from Columbia to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 8, 2026.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:44 pm -
1 stop6h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![American Airlines logo]()
$373
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:15 am -
1 stop9h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![United Airlines logo]()
$435
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1211:59 am -
2 stops9h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![American Airlines logo]()
$441
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/293:15 pm -
3 stops41h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$451
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/43:19 pm -
2 stops19h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$486
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/297:48 pm -
1 stop6h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![American Airlines logo]()
$753
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/299:01 am -
2 stops25h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![United Airlines logo]()
$926
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:20 am -
3 stops13h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$943
Find flight deals from Columbia to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Columbia (COU) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $348 (American Airlines) |
Popular in | June |
Cheapest in | March |
Average price | $459 |
Cheapflights Fare Finder
Customize your flight search to find flights from Columbia to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
Use the filters below to find and compare flights from Columbia to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbiaSan Francisco
COU Columbia Regional - SFO San Francisco
COUSFO
Columbia Regional
Fri 12/4
5:11 pm-11:25 pm
1 stop8h 14m
San Francisco
Thu 12/10
10:34 am-10:15 pm
1 stop9h 41m
$348
ColumbiaSan Francisco
COU Columbia Regional - SFO San Francisco
COUSFO
Columbia Regional
Fri 10/2
6:32 pm-12:21 am
1 stop7h 49m
San Francisco
Sat 10/10
11:36 pm-9:58 am
1 stop8h 22m
$348
Quickest round-trip
ColumbiaSan Francisco
COU Columbia Regional - SFO San Francisco
COUSFO
Columbia Regional
Sun 10/4
7:44 pm-12:30 am
1 stop6h 46m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$373
ColumbiaSan Francisco
COU Columbia Regional - SFO San Francisco
COUSFO
Columbia Regional
Sat 9/12
6:15 am-1:27 pm
1 stop9h 12m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$435
ColumbiaSan Francisco
COU Columbia Regional - SFO San Francisco
COUSFO
Columbia Regional
Wed 9/23
7:00 am-4:09 pm
2 stops11h 09m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$441
ColumbiaSan Francisco
COU Columbia Regional - SFO San Francisco
COUSFO
Columbia Regional
Sat 10/3
11:19 am-6:54 pm
1 stop9h 35m
San Francisco
Tue 10/6
5:00 am-3:08 pm
1 stop8h 08m
$448
ColumbiaSan Francisco
COU Columbia Regional - SFO San Francisco
COUSFO
Columbia Regional
Sat 10/17
6:24 pm-12:30 am
1 stop8h 06m
San Francisco
Wed 10/21
6:00 am-5:54 pm
1 stop9h 54m
$448
ColumbiaSan Francisco
COU Columbia Regional - SFO San Francisco
COUSFO
Columbia Regional
Sun 11/29
3:15 pm-6:46 am
3 stops41h 31m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$451
ColumbiaSan Francisco
COU Columbia Regional - SFO San Francisco
COUSFO
Columbia Regional
Sun 10/4
3:19 pm-8:56 am
2 stops19h 37m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$486
ColumbiaSan Francisco
COU Columbia Regional - SFO San Francisco
COUSFO
Columbia Regional
Sat 9/19
7:00 am-3:30 pm
2 stops10h 30m
San Francisco
Wed 9/23
9:00 am-8:12 pm
1 stop9h 12m
$486
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Columbia to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbia to San Francisco in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Columbia, Missouri-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Columbia, Missouri-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Columbia, Missouri-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Columbia to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Columbia with our price prediction graph.
COU-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Columbia to San Francisco
What is the cheapest month to book a flight from Columbia, Missouri to San Francisco?
Currently, March is the cheapest month in which you can book a flight from Columbia, Missouri to San Francisco (average of $298). Flying from Columbia, Missouri to San Francisco in June is currently the most expensive (average of $682). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Columbia, Missouri to San Francisco?
Airfare is below average for this route at the moment.
Columbia, Missouri to San Francisco flights typically cost between $373 and $797 in October.The cheapest round-trip price found within the last 5 days was $348 on American Airlines (Oct 2-Oct 10).
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated September 8, 2026.
Get a feel of what it's like to fly with United Airlines and American Airlines from Columbia to San Francisco by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.4
Food
6.6
Entertainment
7.1
Crew
8.1
Comfort
7.3
Boarding
7.7
Reviews
1 / 20
10.0
ExcellentKathy,Jun 2024
RDD - SFO
Overall
7.4
Food
6.6
Entertainment
7.1
Crew
8.1
Comfort
7.3
Boarding
7.7
Reviews
1 / 20
10.0
ExcellentKathy,Jun 2024
RDD - SFO
Overall
7.4
Food
6.6
Entertainment
7.1
Crew
8.1
Comfort
7.3
Boarding
7.7
Reviews
1 / 20
10.0
ExcellentKathy,Jun 2024
RDD - SFO
Related info for your journey
Find useful and relevant information for your journey from Columbia to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Emeryville
San Bruno
Burlingame
Rancho Cordova
Roseville
Fairfield
Vallejo
Cupertino
Newark
Hayward
San Ramon
Redwood City
Manteca
San Carlos
Turlock
Davis
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Columbia and San Francisco flights
Browse other Columbia and San Francisco flight options. Last updated on September 8, 2026.
Other flights from Columbia
Browse through other flights departing from Columbia. Flights are based on user searches made on Cheapflights and were last updated on September 8, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 8, 2026.
Top 2 airlines flying from Columbia to San Francisco
Discover the top 2 airlines that operate flights from Columbia to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$278 | Average$404 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$348 | Average$557 | FlexibilityNo cancel fee | On-time71% |