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South Carolina

$222+ Cheap flights from Panama City (PTY) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Apr 29 — May 61
Wed 4/29
Wed 5/6
1 adult, Economy
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Cheap flight deals from Panama City to South Carolina

Cheapest flights from Panama City to South Carolina
Explore the most affordable flight options available from Panama City to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 30, 2026.

This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/154:37 pm
PTY
-
CLT
1 stop15h 30m
American Airlines
Tue 1/57:11 am
CLT
-
PTY
1 stop8h 43m
American Airlines
Deal found 3/30$464
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:21 pm
PTY
-
CLT
1 stop8h 36m
Delta
Mon 9/145:30 am
CLT
-
PTY
1 stop8h 26m
Delta
Deal found 3/30$465
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:15 pm
PTY
-
CHS
1 stop8h 44m
Delta
Tue 6/166:15 am
CHS
-
PTY
1 stop7h 54m
Delta
Deal found 3/30$476
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/103:40 pm
PTY
-
CLT
2 stops13h 47m
American Airlines
Mon 9/149:00 pm
CLT
-
PTY
1 stop18h 10m
American Airlines
Deal found 3/28$478
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/63:41 pm
PTY
-
CLT
1 stop7h 44m
Multiple Airlines
Thu 4/306:30 am
CLT
-
PTY
1 stop13h 50m
Multiple Airlines
Deal found 3/28$493
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:14 pm
PTY
-
CHS
1 stop9h 45m
American Airlines
Wed 6/36:18 pm
CHS
-
PTY
2 stops18h 56m
American Airlines
Deal found 3/29$494
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/13:30 pm
PTY
-
CHS
2 stops17h 38m
United Airlines
Tue 6/166:30 pm
CHS
-
PTY
2 stops22h 42m
United Airlines
Deal found 3/30$495
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:21 pm
PTY
-
CHS
1 stop17h 19m
Delta
Sat 11/75:55 pm
CHS
-
PTY
1 stop20h 01m
Delta
Deal found 3/29$505
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:00 am
PTY
-
CHS
2 stops23h 08m
United Airlines
Wed 6/310:00 am
CHS
-
PTY
2 stops10h 31m
United Airlines
Deal found 3/29$509
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/293:35 pm
PTY
-
CHS
2 stops17h 44m
American Airlines
Sat 11/74:59 pm
CHS
-
PTY
2 stops20h 37m
American Airlines
Deal found 3/29$513
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/510:00 am
PTY
-
CHS
1 stop11h 15m
United Airlines
Mon 6/1511:31 am
CHS
-
PTY
2 stops27h 43m
United Airlines
Deal found 3/27$515
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/33:20 pm
PTY
-
CHS
1 stop26h 40m
American Airlines
Sat 9/128:10 pm
CHS
-
PTY
1 stop19h 00m
American Airlines
Deal found 3/29$521

Find flight deals from Panama City to South Carolina

Keep the following information in mind while searching for Panama City to South Carolina flight deals. Data was last updated March 30, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$431
(Mytrip)

One-way from

$222
(Kiwi.com)
Provider with most accurate pricing for Panama City Tocumen Intl-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Myrtle Beach Intl flights.
Search Deals
From Panama City Tocumen Intl to South Carolina
Search Deals
One-way flight from Panama City Tocumen Intl to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Mon 6/1

2:15 pm-11:59 pm

1 stop8h 44m

Charleston

Tue 6/16

6:15 am-1:09 pm

1 stop7h 54m

$476

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Mon 4/6

3:41 pm-12:25 am

1 stop7h 44m

Charlotte Douglas

Thu 4/30

6:30 am-7:20 pm

1 stop13h 50m

$493

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 5/13

9:45 am-11:59 pm

2 stops13h 14m

Charleston

Wed 5/20

7:44 pm-6:37 pm

2 stops23h 53m

$495

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Mon 6/1

3:30 pm-10:08 am

2 stops17h 38m

Charleston

Tue 6/16

6:50 am-2:14 pm

1 stop8h 24m

$495

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 5/27

1:14 pm-11:59 pm

1 stop9h 45m

Charleston

Wed 6/3

7:34 pm-12:13 pm

1 stop17h 39m

$498

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 5/27

3:30 pm-10:08 am

2 stops17h 38m

Charleston

Wed 6/3

10:00 am-7:31 pm

2 stops10h 31m

$509

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 4/30

1:49 pm-10:57 pm

1 stop8h 08m

Charlotte Douglas

Sun 5/10

8:45 pm-12:46 pm

1 stop17h 01m

$562

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Mon 5/25

3:10 pm-11:40 pm

2 stops31h 30m

Charlotte Douglas

Mon 8/31

7:40 am-2:15 pm

2 stops31h 35m

$564

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Mon 5/4

1:49 pm-9:10 am

1 stop18h 21m

Charlotte Douglas

Tue 5/12

2:44 pm-12:46 pm

1 stop23h 02m

$607

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Thu 4/16

1:49 pm-11:59 pm

1 stop9h 10m

Greenville

Sat 5/2

6:05 pm-12:46 pm

2 stops19h 41m

$641

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/29

Showing 1-10 of 44 resultsSorted by cheapest first
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Best time to book a flight from Panama City to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South Carolina

What is the cheapest month to book a flight from Panama City to South Carolina?

Currently, December is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $148). Flying from Panama City to South Carolina in March is currently the most expensive (average of $1,239). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama City to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South Carolina?

    Panama City Tocumen Intl (PTY) is the airport you will fly out of if you book a flight from Panama City to South Carolina. It is only a 11.4 mi journey to Tocumen Intl (PTY) from Panama City’s city center.

  • How long is the flight from Panama City to South Carolina?

    Delta, United Airlines, and American Airlines can get you from Panama City to South Carolina in just under 8h 08m. Your travel time can differ by up to 5h 06m. The distance between Panama City and South Carolina is about 1808 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Panama City to South Carolina?

    The most popular flight routes from Panama City to South Carolina are Panama City Tocumen Intl - Charleston, Panama City Tocumen Intl - Charlotte Douglas and Panama City Tocumen Intl - Myrtle Beach Intl.

  • Can I find deals for flights from Panama City to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama City to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South Carolina.

  • Can I find deals for business class flights from Panama City to South Carolina?

    Yes. Cheapflights offers flight deals from Panama City to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $148). Flying from Panama City to South Carolina in March is currently the most expensive (average of $1,239). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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