South Carolina

$257+ Cheap flights from Panama City (PTY) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/7. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Mar 2 — Mar 91
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Cheap flight deals from Panama City to South Carolina

Cheapest flights from Panama City to South Carolina
Explore the most affordable flight options available from Panama City to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 31, 2026.

This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/110:00 am
PTY
-
CHS
1 stop11h 12m
United Airlines
Tue 6/167:00 am
CHS
-
PTY
1 stop12h 37m
United Airlines
Deal found 1/30$399
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:10 pm
PTY
-
CHS
2 stops21h 27m
American Airlines
Tue 6/161:06 pm
CHS
-
PTY
2 stops24h 04m
American Airlines
Deal found 1/30$436
This Avianca Connect deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/162:55 pm
PTY
-
CLT
2 stops20h 24m
Multiple Airlines
Mon 3/236:00 am
CLT
-
PTY
2 stops19h 40m
Multiple Airlines
Deal found 1/30$440
This Avianca Connect deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/125:50 pm
PTY
-
CLT
2 stops18h 30m
Multiple Airlines
Tue 2/175:55 am
CLT
-
PTY
2 stops19h 05m
Multiple Airlines
Deal found 1/31$454
This Avianca Connect deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/92:55 am
PTY
-
CLT
2 stops13h 59m
Multiple Airlines
Tue 2/177:00 am
CLT
-
PTY
2 stops18h 00m
Multiple Airlines
Deal found 1/30$472
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/311:10 pm
PTY
-
CHS
2 stops19h 58m
American Airlines
Sat 6/64:16 pm
CHS
-
PTY
2 stops20h 54m
American Airlines
Deal found 1/31$472
This Avianca Connect deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/293:05 am
PTY
-
CLT
2 stops16h 24m
Multiple Airlines
Thu 5/146:00 am
CLT
-
PTY
2 stops20h 05m
Multiple Airlines
Deal found 1/29$474
This Avianca Connect deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/203:05 am
PTY
-
CLT
2 stops16h 24m
Multiple Airlines
Mon 5/2511:12 am
CLT
-
PTY
2 stops15h 43m
Multiple Airlines
Deal found 1/29$499
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/103:20 pm
PTY
-
CLT
1 stop29h 32m
United Airlines
Mon 9/144:45 pm
CLT
-
PTY
1 stop22h 29m
United Airlines
Deal found 1/30$504
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2910:00 am
PTY
-
CLT
1 stop10h 41m
United Airlines
Tue 5/511:42 am
CLT
-
PTY
1 stop7h 55m
United Airlines
Deal found 1/30$513
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/273:10 pm
PTY
-
CHS
1 stop7h 49m
American Airlines
Sun 3/296:00 am
CHS
-
PTY
1 stop10h 01m
American Airlines
Deal found 1/30$513
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:49 pm
PTY
-
CLT
2 stops15h 37m
American Airlines
Tue 5/510:24 pm
CLT
-
PTY
2 stops15h 12m
American Airlines
Deal found 1/30$517

Find flight deals from Panama City to South Carolina

Keep the following information in mind while searching for Panama City to South Carolina flight deals. Data was last updated January 31, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$399
(United Airlines)

One-way from

$244
(Avianca Connect)
Provider with most accurate pricing for Panama City Tocumen Intl-Myrtle Beach Intl flight deals.
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Myrtle Beach Intl flights.
From Panama City Tocumen Intl to South Carolina
One-way flight from Panama City Tocumen Intl to South Carolina

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 31, 2026.
Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.

Fly from

Panama City

Fly to

South Carolina

Route

Depart

Return

Price

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Mon 6/1

10:00 am-10:12 pm

1 stop11h 12m

Charleston

Tue 6/16

7:00 am-6:37 pm

1 stop12h 37m

$399

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Mon 6/1

1:10 pm-11:37 am

2 stops21h 27m

Charleston

Tue 6/16

1:06 pm-12:10 pm

2 stops24h 04m

$436

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Mon 3/16

2:55 pm-12:19 pm

2 stops20h 24m

Charlotte Douglas

Mon 3/23

6:00 am-12:40 am

2 stops19h 40m

$440

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 2/12

5:50 pm-12:20 pm

2 stops18h 30m

Charlotte Douglas

Tue 2/17

5:55 am-1:00 am

2 stops19h 05m

$454

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sun 5/31

1:10 pm-10:08 am

2 stops19h 58m

Charleston

Sat 6/6

4:16 pm-12:10 pm

2 stops20h 54m

$472

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 5/20

3:05 am-8:29 pm

2 stops16h 24m

Charlotte Douglas

Mon 5/25

11:12 am-1:55 am

2 stops15h 43m

$499

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Mon 4/27

7:55 am-9:41 pm

1 stop12h 46m

Charlotte Douglas

Thu 5/14

6:35 am-6:37 pm

1 stop13h 02m

$504

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Tue 4/28

10:00 am-9:41 pm

1 stop10h 41m

Charlotte Douglas

Thu 5/14

6:35 am-6:37 pm

1 stop13h 02m

$504

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 4/29

9:45 am-9:15 pm

1 stop10h 30m

Charlotte Douglas

Thu 5/14

6:35 am-2:14 pm

1 stop8h 39m

$504

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 3/27

3:10 pm-11:59 pm

1 stop7h 49m

Charleston

Sun 3/29

6:00 am-3:01 pm

1 stop10h 01m

$513

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/31

Showing 1-10 of 32 results
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Best time to book a flight from Panama City to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South Carolina

What is the cheapest month to book a flight from Panama City to South Carolina?

Currently, December is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $148). Flying from Panama City to South Carolina in July is currently the most expensive (average of $479). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Panama City to South Carolina?

Related info for your journey

Find useful and relevant information for your journey from Panama City to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Panama City to South Carolina?

    Panama City Tocumen Intl (PTY) is the airport you will fly out of if you book a flight from Panama City to South Carolina. It is only a 11.4 mi journey to Tocumen Intl (PTY) from Panama City’s city center.

  • How long is the flight from Panama City to South Carolina?

    United Airlines and American Airlines can get you from Panama City to South Carolina in just under 11h 12m. Your travel time can differ by up to 10h 15m. The distance between Panama City and South Carolina is about 1645 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Panama City to South Carolina?

  • Can I find deals for flights from Panama City to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama City to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South Carolina.

  • Can I find deals for business class flights from Panama City to South Carolina?

    Yes. Cheapflights offers flight deals from Panama City to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $148). Flying from Panama City to South Carolina in July is currently the most expensive (average of $479). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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