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South Carolina

$269+ Cheap flights from Panama City (PTY) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Panama City to South Carolina

Keep the following information in mind while searching for Panama City to South Carolina flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$377
(Delta)

One-way from

$269
(Mytrip)
Provider with most accurate pricing for Panama City Tocumen Intl-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Myrtle Beach Intl flights.
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From Panama City Tocumen Intl to South Carolina
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One-way flight from Panama City Tocumen Intl to South Carolina
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Find flight deals from Panama City to South Carolina

Cheapest flights from Panama City to South Carolina
Explore the most affordable flight options available from Panama City to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:00 amPTY - CHS
1 stop7h 08mDelta
Thu 1/110:18 amCHS - PTY
1 stop9h 42mDelta
Deal found 10/30$377
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/234:55 pmPTY - CHS
1 stop7h 50mAmerican Airlines
Thu 1/18:08 pmCHS - PTY
2 stops19h 46mAmerican Airlines
Deal found 10/30$390
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/202:43 pmPTY - CLT
1 stop10h 04mAmerican Airlines
Thu 11/276:45 pmCLT - PTY
1 stop18h 58mAmerican Airlines
Deal found 10/28$410
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/212:43 pmPTY - CLT
1 stop10h 04mAmerican Airlines
Sat 12/68:26 pmCLT - PTY
1 stop17h 21mAmerican Airlines
Deal found 10/28$418
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/163:46 pmPTY - CLT
1 stop7h 56mDelta
Wed 12/317:05 amCLT - PTY
1 stop12h 55mDelta
Deal found 10/29$419
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/32:50 pmPTY - CLT
1 stop9h 09mAmerican Airlines
Wed 12/107:58 pmCLT - PTY
1 stop17h 49mAmerican Airlines
Deal found 10/29$425
This Avianca Connect deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/52:55 amPTY - CLT
2 stops14h 30mMultiple Airlines
Thu 11/278:52 pmCLT - PTY
2 stops17h 08mMultiple Airlines
Deal found 10/28$437
This SmartFares deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:00 amPTY - CLT
1 stop11h 10mDelta
Thu 1/18:15 amCLT - PTY
1 stop11h 45mDelta
Deal found 10/29$449
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/262:53 pmPTY - CAE
2 stops19h 15mAmerican Airlines
Tue 12/307:59 pmCAE - PTY
2 stops17h 54mAmerican Airlines
Deal found 10/27$461
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/34:43 pmPTY - CLT
1 stop7h 16mAmerican Airlines
Tue 1/135:15 amCLT - PTY
1 stop8h 12mAmerican Airlines
Deal found 10/29$462
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/204:55 pmPTY - CHS
1 stop15h 52mAmerican Airlines
Mon 1/195:41 pmCHS - PTY
2 stops19h 46mAmerican Airlines
Deal found 10/30$468
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/224:55 pmPTY - CHS
1 stop7h 50mAmerican Airlines
Sun 1/46:00 amCHS - PTY
1 stop7h 53mAmerican Airlines
Deal found 10/29$483

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.

Fly from

Panama City

Fly to

South Carolina

Route

Depart

Return

Price

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 12/23

8:00 am-3:08 pm

1 stop7h 08m

Charleston

Thu 1/1

10:18 am-8:00 pm

1 stop9h 42m

$377

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 12/23

4:55 pm-12:45 am

1 stop7h 50m

Charleston

Thu 1/1

8:08 pm-3:54 pm

2 stops19h 46m

$390

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sat 2/21

4:41 pm-4:03 pm

1 stop23h 22m

Charleston

Wed 2/25

5:07 pm-5:07 pm

1 stop24h 00m

$396

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 11/20

2:43 pm-12:47 am

1 stop10h 04m

Charlotte Douglas

Thu 11/27

6:45 pm-1:43 pm

1 stop18h 58m

$410

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Tue 12/16

3:46 pm-11:42 pm

1 stop7h 56m

Charlotte Douglas

Wed 12/31

7:05 am-8:00 pm

1 stop12h 55m

$419

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 12/3

4:43 pm-6:29 am

2 stops13h 46m

Charlotte Douglas

Wed 12/10

6:45 pm-1:47 pm

1 stop19h 02m

$429

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 2/11

2:27 pm-6:35 am

2 stops16h 08m

Charlotte Douglas

Fri 2/20

5:00 am-3:14 pm

1 stop10h 14m

$429

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Sun 2/1

2:27 pm-11:59 pm

1 stop9h 32m

Charlotte Douglas

Sun 2/8

6:30 am-1:27 pm

1 stop6h 57m

$439

Panama CityColumbia

PTY - CAE

PTYCAE

Panama City Tocumen Intl

Fri 12/26

2:53 pm-10:08 am

2 stops19h 15m

Columbia Metropolitan

Tue 12/30

7:59 pm-1:53 pm

2 stops17h 54m

$461

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 12/3

4:43 pm-6:29 am

2 stops13h 46m

Charlotte Douglas

Tue 1/13

6:30 am-1:27 pm

1 stop6h 57m

$466

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 38 results
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Best time to book a flight from Panama City to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South Carolina

What is the cheapest month to book a flight from Panama City to South Carolina?

Currently, November is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $205). Flying from Panama City to South Carolina in January is currently the most expensive (average of $517). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SC?

Find hourly flight availability from Panama City to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 35% on flights from Panama City to South Carolina by exploring options for tickets at noon.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 30, 2025.
Read through reviews of airlines operating flights from Panama City to South Carolina, such as Delta and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Mary,Oct 2025

AMS - PDX

It's specail being able to fly non-stop from Amsterdam all the way home to Portland, Oregon!
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Mary,Oct 2025

AMS - PDX

It's specail being able to fly non-stop from Amsterdam all the way home to Portland, Oregon!
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Mary,Oct 2025

AMS - PDX

It's specail being able to fly non-stop from Amsterdam all the way home to Portland, Oregon!

Related info for your journey

Find useful and relevant information for your journey from Panama City to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South Carolina?

    Panama City Tocumen Intl (PTY) is the airport you will fly out of if you book a flight from Panama City to South Carolina. It is only a 11.4 mi journey to Tocumen Intl (PTY) from Panama City’s city center.

  • How long is the flight from Panama City to South Carolina?

    Delta, American Airlines, and United Airlines can get you from Panama City to South Carolina in just under 7h 08m. Your travel time can differ by up to 16h 14m. The distance between Panama City and South Carolina is about 1645 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Panama City to South Carolina one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $293. However, be on the lookout for offers from United Airlines and Delta, as they are both options that can get you from Panama City to South Carolina for a low price.

  • What are the most popular routes from Panama City to South Carolina?

    The most popular flight routes from Panama City to South Carolina are Panama City Tocumen Intl - Charlotte Douglas, Panama City Tocumen Intl - Columbia Metropolitan and Panama City Tocumen Intl - Charleston.

  • Can I find deals for flights from Panama City to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama City to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South Carolina.

  • Can I find deals for business class flights from Panama City to South Carolina?

    Yes. Cheapflights offers flight deals from Panama City to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to South Carolina?

    Currently, November is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $205). Flying from Panama City to South Carolina in January is currently the most expensive (average of $517). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Panama City to South Carolina

Discover the top 2 airlines that operate flights from Panama City to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$205Average$603FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$397Average$546FlexibilityNo cancel feeOn-time71%

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