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South Carolina

$240+ Cheap flights from Panama City (PTY) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/31. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
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Cheap flight deals from Panama City to South Carolina

Cheapest flights from Panama City to South Carolina
Explore the most affordable flight options available from Panama City to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

This Delta deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/163:46 pmPTY - CLT
1 stop7h 56mDelta
Wed 12/316:00 amCLT - PTY
1 stop7h 57mDelta
Deal found 12/14$424
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/164:43 pmPTY - CLT
2 stops13h 46mAmerican Airlines
Wed 12/318:57 amCLT - PTY
1 stop6h 57mAmerican Airlines
Deal found 12/14$434
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/204:41 pmPTY - CLT
1 stop29h 01mUnited Airlines
Thu 2/266:33 amCLT - PTY
1 stop10h 34mUnited Airlines
Deal found 12/15$469
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:55 amPTY - CLT
1 stop12h 47mUnited Airlines
Sat 2/284:50 pmCLT - PTY
1 stop21h 55mUnited Airlines
Deal found 12/15$490
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/194:55 pmPTY - CLT
1 stop15h 16mAmerican Airlines
Tue 1/65:15 amCLT - PTY
1 stop10h 16mAmerican Airlines
Deal found 12/15$499
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/164:43 pmPTY - CLT
1 stop20h 56mAmerican Airlines
Fri 1/95:15 amCLT - PTY
1 stop10h 23mAmerican Airlines
Deal found 12/15$507
This United Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/244:41 pmPTY - CLT
1 stop29h 01mUnited Airlines
Sat 1/34:45 pmCLT - PTY
1 stop24h 22mUnited Airlines
Deal found 12/13$511
This Delta deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/278:00 amPTY - CLT
1 stop11h 10mDelta
Thu 1/85:25 amCLT - PTY
1 stop8h 30mDelta
Deal found 12/15$522
This Delta deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/153:46 pmPTY - CHS
1 stop8h 04mDelta
Mon 12/298:15 amCHS - PTY
1 stop11h 45mDelta
Deal found 12/14$540
This American Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:55 pmPTY - CHS
2 stops21h 08mAmerican Airlines
Thu 1/18:07 pmCHS - PTY
1 stop19h 47mAmerican Airlines
Deal found 12/12$545
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:53 pmPTY - CHS
2 stops21h 28mAmerican Airlines
Wed 12/315:10 amCHS - PTY
2 stops10h 44mAmerican Airlines
Deal found 12/15$554
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/152:50 pmPTY - CHS
1 stop9h 56mAmerican Airlines
Mon 12/298:08 pmCHS - PTY
2 stops19h 46mAmerican Airlines
Deal found 12/15$575

Find flight deals from Panama City to South Carolina

Keep the following information in mind while searching for Panama City to South Carolina flight deals. Data was last updated December 15, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$369
(Kiwi.com)

One-way from

$240
(United Airlines)
Provider with most accurate pricing for Panama City Tocumen Intl-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Myrtle Beach Intl flights.
Search Deals
From Panama City Tocumen Intl to South Carolina
Search Deals
One-way flight from Panama City Tocumen Intl to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.

Fly from

Panama City

Fly to

South Carolina

Route

Depart

Return

Price

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 1/29

9:33 pm-10:38 am

1 stop13h 05m

Charlotte Douglas

Thu 2/5

8:38 pm-8:06 am

1 stop11h 28m

$369

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sat 2/14

4:41 pm-4:03 pm

1 stop23h 22m

Charleston

Wed 2/18

11:15 am-8:02 pm

1 stop8h 47m

$396

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 5/29

1:50 pm-10:00 am

2 stops19h 10m

Charleston

Mon 6/1

6:32 pm-12:25 pm

2 stops18h 53m

$397

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sat 2/14

4:05 pm-1:55 pm

2 stops21h 50m

Charleston

Wed 2/18

7:45 pm-1:50 pm

2 stops18h 05m

$416

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 4/30

7:55 am-9:52 pm

1 stop12h 57m

Charlotte Douglas

Mon 5/4

6:30 am-2:14 pm

1 stop8h 44m

$481

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 4/30

10:00 am-9:52 pm

1 stop10h 52m

Charlotte Douglas

Wed 5/6

11:45 am-6:37 pm

1 stop7h 52m

$481

Panama CityMyrtle Beach

PTY - MYR

PTYMYR

Panama City Tocumen Intl

Thu 1/29

4:50 pm-11:35 am

2 stops18h 45m

Myrtle Beach Intl

Thu 2/5

7:19 pm-1:27 pm

2 stops18h 08m

$482

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Mon 12/29

4:41 pm-9:42 pm

1 stop29h 01m

Charlotte Douglas

Mon 1/5

11:24 am-2:45 pm

1 stop27h 21m

$490

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Fri 5/1

1:55 pm-11:53 pm

1 stop8h 58m

Charlotte Douglas

Tue 5/5

10:25 pm-12:15 pm

1 stop14h 50m

$490

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Wed 2/4

9:55 am-9:57 pm

1 stop12h 02m

Greenville

Sun 2/8

6:49 am-5:07 pm

1 stop10h 18m

$501

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/12

Showing 1-10 of 49 results
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Best time to book a flight from Panama City to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South Carolina

What is the cheapest month to book a flight from Panama City to South Carolina?

Currently, December is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $148). Flying from Panama City to South Carolina in April is currently the most expensive (average of $601). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SC?

Find hourly flight availability from Panama City to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 15, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 35% on flights from Panama City to South Carolina by exploring options for tickets at noon.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 15, 2025.
Read through reviews of airlines operating flights from Panama City to South Carolina, such as Delta. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Overall

7.9

Crew

8.5

Food

7.3

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Overall

7.9

Crew

8.5

Food

7.3

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Panama City to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South Carolina?

    Panama City Tocumen Intl (PTY) is the airport you will fly out of if you book a flight from Panama City to South Carolina. It is only a 11.4 mi journey to Tocumen Intl (PTY) from Panama City’s city center.

  • How long is the flight from Panama City to South Carolina?

    United Airlines, American Airlines, and Delta can get you from Panama City to South Carolina in just under 8h 30m. Your travel time can differ by up to 14h 52m. The distance between Panama City and South Carolina is about 1792 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Panama City to South Carolina?

    The most popular flight routes from Panama City to South Carolina are Panama City Tocumen Intl - Charlotte Douglas, Panama City Tocumen Intl - Charleston and Panama City Tocumen Intl - Columbia Metropolitan.

  • Can I find deals for flights from Panama City to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama City to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South Carolina.

  • Can I find deals for business class flights from Panama City to South Carolina?

    Yes. Cheapflights offers flight deals from Panama City to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $148). Flying from Panama City to South Carolina in April is currently the most expensive (average of $601). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Panama City to South Carolina

Discover the top airline that operate flights from Panama City to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$205Average$603FlexibilityNo cancel feeOn-timeN/A

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