$257+ Cheap flights from Panama City (PTY) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/7. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Mar 2 — Mar 91
1 adult, Economy
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Find cheap flights from Panama City to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to South Carolina
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Cheapest flights from Panama City to South CarolinaExplore the most affordable flight options available from Panama City to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 31, 2026.
Explore the most affordable flight options available from Panama City to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 31, 2026.
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/110:00 am
PTY
- CHS
1 stop11h 12m
United Airlines
Tue 6/167:00 am
CHS
- PTY
1 stop12h 37m
United Airlines
Deal found 1/30![United Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:10 pm
PTY
- CHS
2 stops21h 27m
American Airlines
Tue 6/161:06 pm
CHS
- PTY
2 stops24h 04m
American Airlines
Deal found 1/30![American Airlines logo]()
$436
This Avianca Connect deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/162:55 pm
PTY
- CLT
2 stops20h 24m
Multiple Airlines
Mon 3/236:00 am
CLT
- PTY
2 stops19h 40m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$440
This Avianca Connect deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/125:50 pm
PTY
- CLT
2 stops18h 30m
Multiple Airlines
Tue 2/175:55 am
CLT
- PTY
2 stops19h 05m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$454
This Avianca Connect deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/92:55 am
PTY
- CLT
2 stops13h 59m
Multiple Airlines
Tue 2/177:00 am
CLT
- PTY
2 stops18h 00m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$472
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/311:10 pm
PTY
- CHS
2 stops19h 58m
American Airlines
Sat 6/64:16 pm
CHS
- PTY
2 stops20h 54m
American Airlines
Deal found 1/31![American Airlines logo]()
$472
This Avianca Connect deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/293:05 am
PTY
- CLT
2 stops16h 24m
Multiple Airlines
Thu 5/146:00 am
CLT
- PTY
2 stops20h 05m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$474
This Avianca Connect deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/203:05 am
PTY
- CLT
2 stops16h 24m
Multiple Airlines
Mon 5/2511:12 am
CLT
- PTY
2 stops15h 43m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$499
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/103:20 pm
PTY
- CLT
1 stop29h 32m
United Airlines
Mon 9/144:45 pm
CLT
- PTY
1 stop22h 29m
United Airlines
Deal found 1/30![United Airlines logo]()
$504
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2910:00 am
PTY
- CLT
1 stop10h 41m
United Airlines
Tue 5/511:42 am
CLT
- PTY
1 stop7h 55m
United Airlines
Deal found 1/30![United Airlines logo]()
$513
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/273:10 pm
PTY
- CHS
1 stop7h 49m
American Airlines
Sun 3/296:00 am
CHS
- PTY
1 stop10h 01m
American Airlines
Deal found 1/30![American Airlines logo]()
$513
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:49 pm
PTY
- CLT
2 stops15h 37m
American Airlines
Tue 5/510:24 pm
CLT
- PTY
2 stops15h 12m
American Airlines
Deal found 1/30![American Airlines logo]()
$517
Best flights from Panama City to South CarolinaDiscover carefully curated flight deals from Panama City to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated January 31, 2026.
Discover carefully curated flight deals from Panama City to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated January 31, 2026.
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/110:00 am
PTY
- CHS
1 stop11h 12m
United Airlines
Tue 6/167:00 am
CHS
- PTY
1 stop12h 37m
United Airlines
Deal found 1/30![United Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:10 pm
PTY
- CHS
2 stops21h 27m
American Airlines
Tue 6/161:06 pm
CHS
- PTY
2 stops24h 04m
American Airlines
Deal found 1/30![American Airlines logo]()
$436
This Avianca Connect deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/162:55 pm
PTY
- CLT
2 stops20h 24m
Multiple Airlines
Mon 3/236:00 am
CLT
- PTY
2 stops19h 40m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$440
This Avianca Connect deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/125:50 pm
PTY
- CLT
2 stops18h 30m
Multiple Airlines
Tue 2/175:55 am
CLT
- PTY
2 stops19h 05m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$454
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/311:10 pm
PTY
- CHS
2 stops19h 58m
American Airlines
Sat 6/64:16 pm
CHS
- PTY
2 stops20h 54m
American Airlines
Deal found 1/31![American Airlines logo]()
$472
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/277:55 am
PTY
- CLT
1 stop12h 46m
United Airlines
Thu 5/146:35 am
CLT
- PTY
1 stop13h 02m
United Airlines
Deal found 1/29![United Airlines logo]()
$504
This Avianca Connect deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/203:05 am
PTY
- CLT
2 stops16h 24m
Multiple Airlines
Mon 5/2511:12 am
CLT
- PTY
2 stops15h 43m
Multiple Airlines
Deal found 1/29![Multiple Airlines logo]()
$499
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2810:00 am
PTY
- CLT
1 stop10h 41m
United Airlines
Thu 5/146:35 am
CLT
- PTY
1 stop13h 02m
United Airlines
Deal found 1/29![United Airlines logo]()
$504
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/273:10 pm
PTY
- CHS
1 stop7h 49m
American Airlines
Sun 3/296:00 am
CHS
- PTY
1 stop10h 01m
American Airlines
Deal found 1/30![American Airlines logo]()
$513
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/299:45 am
PTY
- CLT
1 stop10h 30m
United Airlines
Thu 5/146:35 am
CLT
- PTY
1 stop8h 39m
United Airlines
Deal found 1/29![United Airlines logo]()
$504
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:49 pm
PTY
- CLT
2 stops15h 37m
American Airlines
Tue 5/59:44 pm
CLT
- PTY
1 stop15h 52m
American Airlines
Deal found 1/30![American Airlines logo]()
$517
This Expedia deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3111:25 am
PTY
- CHS
3 stops26h 15m
Multiple Airlines
Sat 6/68:00 pm
CHS
- PTY
2 stops15h 30m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$518
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2910:00 am
PTY
- CLT
1 stop10h 41m
United Airlines
Tue 5/511:42 am
CLT
- PTY
1 stop7h 55m
United Airlines
Deal found 1/30![United Airlines logo]()
$513
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/11:49 pm
PTY
- CLT
1 stop9h 10m
American Airlines
Fri 5/155:05 am
CLT
- PTY
1 stop8h 31m
American Airlines
Deal found 1/30![American Airlines logo]()
$518
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/1312:03 pm
PTY
- MYR
1 stop20h 10m
Multiple Airlines
Mon 2/169:09 am
MYR
- PTY
2 stops15h 31m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$561
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3110:00 am
PTY
- CHS
1 stop11h 12m
United Airlines
Sat 6/67:00 am
CHS
- PTY
1 stop10h 12m
United Airlines
Deal found 1/31![United Airlines logo]()
$531
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/124:05 pm
PTY
- CHS
2 stops20h 37m
American Airlines
Sun 3/18:25 pm
CHS
- PTY
2 stops18h 50m
American Airlines
Deal found 1/30![American Airlines logo]()
$562
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/198:55 am
PTY
- CHS
1 stop13h 03m
United Airlines
Tue 2/246:35 am
CHS
- PTY
1 stop10h 32m
United Airlines
Deal found 1/30![United Airlines logo]()
$553
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2810:00 am
PTY
- GSP
1 stop11h 11m
United Airlines
Mon 6/14:55 pm
GSP
- PTY
1 stop24h 17m
United Airlines
Deal found 1/29![United Airlines logo]()
$565
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/132:40 pm
PTY
- MYR
2 stops21h 12m
American Airlines
Mon 2/165:18 pm
MYR
- PTY
2 stops20h 22m
American Airlines
Deal found 1/30![American Airlines logo]()
$697
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:51 pm
PTY
- CAE
2 stops23h 58m
United Airlines
Mon 6/110:18 am
CAE
- PTY
2 stops11h 09m
United Airlines
Deal found 1/29![United Airlines logo]()
$6,209
Last-minute flights from Panama City to South CarolinaDiscover last-minute flight deals from Panama City to South Carolina. Data last updated January 31, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to South Carolina. Data last updated January 31, 2026 and is based on user searches.
This Avianca Connect deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/12:55 am
PTY
- CLT
2 stops15h 53m
Multiple Airlines
Fri 2/135:55 am
CLT
- PTY
2 stops18h 45m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$615
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/42:27 pm
PTY
- CAE
2 stops22h 01m
American Airlines
Fri 2/67:10 pm
CAE
- PTY
2 stops18h 17m
American Airlines
Deal found 1/31![American Airlines logo]()
$740
This Avianca Connect deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/52:55 pm
PTY
- CLT
2 stops21h 27m
Multiple Airlines
Thu 2/125:55 am
CLT
- PTY
2 stops19h 05m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$527
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/64:41 pm
PTY
- CHS
1 stop23h 39m
United Airlines
Tue 2/105:13 pm
CHS
- PTY
1 stop26h 25m
United Airlines
Deal found 1/29![United Airlines logo]()
$633
This Avianca Connect deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/92:55 am
PTY
- CLT
2 stops13h 59m
Multiple Airlines
Tue 2/177:00 am
CLT
- PTY
2 stops18h 00m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$472
This Avianca Connect deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/125:50 pm
PTY
- CLT
2 stops18h 30m
Multiple Airlines
Tue 2/175:55 am
CLT
- PTY
2 stops19h 05m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$454
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/124:05 pm
PTY
- CHS
2 stops20h 37m
American Airlines
Sun 3/18:25 pm
CHS
- PTY
2 stops18h 50m
American Airlines
Deal found 1/30![American Airlines logo]()
$562
This Kiwi.com deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/1312:03 pm
PTY
- MYR
1 stop20h 10m
Multiple Airlines
Mon 2/169:09 am
MYR
- PTY
2 stops15h 31m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$561
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/132:40 pm
PTY
- MYR
2 stops21h 12m
American Airlines
Mon 2/165:18 pm
MYR
- PTY
2 stops20h 22m
American Airlines
Deal found 1/30![American Airlines logo]()
$697
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/1511:35 am
PTY
- CLT
1 stop10h 22m
United Airlines
Wed 2/2511:23 am
CLT
- PTY
1 stop8h 39m
United Airlines
Deal found 1/30![United Airlines logo]()
$611
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/198:55 am
PTY
- CHS
1 stop13h 03m
United Airlines
Tue 2/246:35 am
CHS
- PTY
1 stop10h 32m
United Airlines
Deal found 1/30![United Airlines logo]()
$553
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/192:40 pm
PTY
- CHS
2 stops20h 49m
American Airlines
Tue 2/246:00 am
CHS
- PTY
1 stop7h 40m
American Airlines
Deal found 1/31![American Airlines logo]()
$616
One-way flights from Panama City to South CarolinaSearch for one-way flight options from Panama City to South Carolina. Find affordable one-way fares based on user searches. Data last updated January 31, 2026.
Search for one-way flight options from Panama City to South Carolina. Find affordable one-way fares based on user searches. Data last updated January 31, 2026.
This Mytrip deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:30 am
PTY
- CLT
2 stops13h 59m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$257
This Mytrip deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/135:50 pm
PTY
- CLT
2 stops30h 06m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$263
This Avianca Connect deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:30 am
PTY
- CLT
2 stops13h 59m
Multiple Airlines
Deal found 1/30![Multiple Airlines logo]()
$283
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/52:40 pm
PTY
- MYR
2 stops20h 59m
American Airlines
Deal found 1/30![American Airlines logo]()
$304
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/73:30 pm
PTY
- CLT
1 stop29h 09m
United Airlines
Deal found 1/29![United Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/35:50 pm
PTY
- CAE
2 stops42h 59m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$323
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1010:00 am
PTY
- GSP
1 stop11h 14m
United Airlines
Deal found 1/31![United Airlines logo]()
$327
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/249:45 am
PTY
- CLT
1 stop10h 30m
United Airlines
Deal found 1/31![United Airlines logo]()
$332
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/101:49 pm
PTY
- GSP
2 stops17h 46m
American Airlines
Deal found 1/30![American Airlines logo]()
$342
This Delta deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/53:15 pm
PTY
- MYR
1 stop8h 42m
Delta
Deal found 1/30![Delta logo]()
$343
This Ovago deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/33:20 pm
PTY
- CAE
1 stop27h 35m
LATAM Airlines
Deal found 1/31![LATAM Airlines logo]()
$366
Find flight deals from Panama City to South Carolina
Keep the following information in mind while searching for Panama City to South Carolina flight deals. Data was last updated January 31, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $399 (United Airlines) |
One-way from | $244 (Avianca Connect) |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 31, 2026.
Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.
Fly from
Panama City
Fly to
South Carolina
Route
Depart
Return
Price
Panama CityCharleston
PTY - CHS
PTYCHS
Panama City Tocumen Intl
Mon 6/1
10:00 am-10:12 pm
1 stop11h 12m
Charleston
Tue 6/16
7:00 am-6:37 pm
1 stop12h 37m
$399
Panama CityCharleston
PTY - CHS
PTYCHS
Panama City Tocumen Intl
Mon 6/1
1:10 pm-11:37 am
2 stops21h 27m
Charleston
Tue 6/16
1:06 pm-12:10 pm
2 stops24h 04m
$436
Panama CityCharlotte
PTY - CLT
PTYCLT
Panama City Tocumen Intl
Mon 3/16
2:55 pm-12:19 pm
2 stops20h 24m
Charlotte Douglas
Mon 3/23
6:00 am-12:40 am
2 stops19h 40m
$440
Panama CityCharlotte
PTY - CLT
PTYCLT
Panama City Tocumen Intl
Thu 2/12
5:50 pm-12:20 pm
2 stops18h 30m
Charlotte Douglas
Tue 2/17
5:55 am-1:00 am
2 stops19h 05m
$454
Panama CityCharleston
PTY - CHS
PTYCHS
Panama City Tocumen Intl
Sun 5/31
1:10 pm-10:08 am
2 stops19h 58m
Charleston
Sat 6/6
4:16 pm-12:10 pm
2 stops20h 54m
$472
Panama CityCharlotte
PTY - CLT
PTYCLT
Panama City Tocumen Intl
Wed 5/20
3:05 am-8:29 pm
2 stops16h 24m
Charlotte Douglas
Mon 5/25
11:12 am-1:55 am
2 stops15h 43m
$499
Panama CityCharlotte
PTY - CLT
PTYCLT
Panama City Tocumen Intl
Mon 4/27
7:55 am-9:41 pm
1 stop12h 46m
Charlotte Douglas
Thu 5/14
6:35 am-6:37 pm
1 stop13h 02m
$504
Panama CityCharlotte
PTY - CLT
PTYCLT
Panama City Tocumen Intl
Tue 4/28
10:00 am-9:41 pm
1 stop10h 41m
Charlotte Douglas
Thu 5/14
6:35 am-6:37 pm
1 stop13h 02m
$504
Panama CityCharlotte
PTY - CLT
PTYCLT
Panama City Tocumen Intl
Wed 4/29
9:45 am-9:15 pm
1 stop10h 30m
Charlotte Douglas
Thu 5/14
6:35 am-2:14 pm
1 stop8h 39m
$504
Panama CityCharleston
PTY - CHS
PTYCHS
Panama City Tocumen Intl
Fri 3/27
3:10 pm-11:59 pm
1 stop7h 49m
Charleston
Sun 3/29
6:00 am-3:01 pm
1 stop10h 01m
$513
Showing 1-10 of 32 results
Best time to book a flight from Panama City to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama City with our price prediction graph.
PTY-CLT
PTY-MYR
PTY-CAE
PTY-GSP
PTY-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to South Carolina
PTY-USSC
PTY-CLT
PTY-MYR
PTY-CAE
PTY-GSP
What is the cheapest month to book a flight from Panama City to South Carolina?
Currently, December is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $148). Flying from Panama City to South Carolina in July is currently the most expensive (average of $479). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.