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South Carolina

$252+ Cheap flights from Panama City (PTY) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/3. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Panama City to South Carolina

Keep the following information in mind while searching for Panama City to South Carolina flight deals. Data was last updated May 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$431
(Trip.com)

One-way from

$252
(Kiwi.com)
Provider with most accurate pricing for Panama City Tocumen Intl-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Myrtle Beach Intl flights.
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From Panama City Tocumen Intl to South Carolina
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One-way flight from Panama City Tocumen Intl to South Carolina
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Find flight deals from Panama City to South Carolina

Cheapest flights from Panama City to South Carolina
Explore the most affordable flight options available from Panama City to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/252:23 pmPTY - CHS
1 stop8h 36mDelta
Sat 8/26:18 amCHS - PTY
1 stop7h 45mDelta
Deal found 4/29$393
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/253:10 pmPTY - CHS
2 stops18h 08mAmerican Airlines
Sat 8/26:00 amCHS - PTY
1 stop9h 15mAmerican Airlines
Deal found 4/29$398
This Trip.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/143:20 amPTY - CLT
2 stops27h 54mMultiple Airlines
Sun 5/189:04 amCLT - PTY
2 stops28h 31mMultiple Airlines
Deal found 4/29$431
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/192:23 pmPTY - CLT
1 stop8h 36mDelta
Mon 6/306:52 amCLT - PTY
1 stop7h 16mDelta
Deal found 4/29$460
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/51:50 pmPTY - CLT
1 stop9h 49mAmerican Airlines
Fri 9/125:35 amCLT - PTY
1 stop7h 50mAmerican Airlines
Deal found 4/28$469
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/281:50 pmPTY - FLO
2 stops19h 49mAmerican Airlines
Sun 7/611:12 amFLO - PTY
2 stops28h 03mAmerican Airlines
Deal found 4/29$482
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/291:20 pmPTY - AGS
2 stops9h 29mAmerican Airlines
Thu 6/52:32 pmAGS - PTY
2 stops24h 53mAmerican Airlines
Deal found 4/29$493
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/213:30 pmPTY - CLT
1 stop29h 46mUnited Airlines
Fri 5/305:05 pmCLT - PTY
1 stop26h 32mUnited Airlines
Deal found 4/29$545
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/31:05 pmPTY - CAE
2 stops19h 48mAmerican Airlines
Fri 5/98:16 pmCAE - PTY
2 stops17h 03mAmerican Airlines
Deal found 4/29$674
This Avianca deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/155:25 pmPTY - CLT
2 stops15h 20mAvianca
Sun 5/186:00 amCLT - PTY
2 stops19h 10mAvianca
Deal found 4/29$932
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2810:55 pmPTY - MYR
1 stop10h 07mUnited Airlines
Sun 7/610:58 amMYR - PTY
1 stop9h 33mUnited Airlines
Deal found 4/29$1,026
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/292:13 pmPTY - AGS
1 stop6h 44mDelta
Thu 6/57:00 amAGS - PTY
1 stop6h 48mDelta
Deal found 4/29$1,112

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.

Fly from

Panama City

Fly to

South Carolina

Route

Depart

Return

Price

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 7/25

2:23 pm-11:59 pm

1 stop8h 36m

Charleston

Sat 8/2

6:18 am-1:03 pm

1 stop7h 45m

$393

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 7/25

3:10 pm-10:18 am

2 stops18h 08m

Charleston

Sat 8/2

6:00 am-2:15 pm

1 stop9h 15m

$398

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 5/14

3:20 am-8:14 am

2 stops27h 54m

Charlotte Douglas

Sun 5/18

9:04 am-12:35 pm

2 stops28h 31m

$431

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 6/19

2:23 pm-11:59 pm

1 stop8h 36m

Charlotte Douglas

Mon 6/30

6:52 am-1:08 pm

1 stop7h 16m

$460

Panama CityFlorence

PTY - FLO

PTYFLO

Panama City Tocumen Intl

Sat 6/28

1:50 pm-10:39 am

2 stops19h 49m

Florence

Sun 7/6

11:12 am-2:15 pm

2 stops28h 03m

$482

Panama CityAugusta

PTY - AGS

PTYAGS

Panama City Tocumen Intl

Thu 5/29

1:20 pm-11:49 pm

2 stops9h 29m

Augusta Bush Field

Thu 6/5

2:32 pm-2:25 pm

2 stops24h 53m

$493

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 6/19

1:50 pm-6:35 am

2 stops15h 45m

Charlotte Douglas

Mon 6/30

6:40 pm-1:00 pm

1 stop19h 20m

$529

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 5/21

3:30 pm-10:16 pm

1 stop29h 46m

Charlotte Douglas

Fri 5/30

5:05 pm-6:37 pm

1 stop26h 32m

$545

Panama CityColumbia

PTY - CAE

PTYCAE

Panama City Tocumen Intl

Sat 5/3

1:05 pm-9:53 am

2 stops19h 48m

Columbia Metropolitan

Fri 5/9

8:16 pm-12:19 pm

2 stops17h 03m

$674

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 5/15

5:25 pm-9:45 am

2 stops15h 20m

Charlotte Douglas

Sun 5/18

6:00 am-12:10 am

2 stops19h 10m

$932

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 22 results
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Best time to book a flight from Panama City to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South Carolina

What is the cheapest month to book a flight from Panama City to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $217). Flying from Panama City to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SC?

Find hourly flight availability from Panama City to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to South Carolina as you normally would.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated May 1, 2025.
Read reviews from past customers who have flown Delta, Copa Airlines and United Airlines from Panama City to South Carolina. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Copa Airlines
7.5
Good
1,415 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Avianca
6.7
Okay
2,317 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Panama City to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South Carolina?

    Panama City Tocumen Intl (PTY) is the airport you will fly out of if you book a flight from Panama City to South Carolina. It is only a 11.4 mi journey to Tocumen Intl (PTY) from Panama City’s city center.

  • What are the cheapest airlines to fly from Panama City to South Carolina one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $284. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Panama City to South Carolina for a low price.

  • What are the most popular routes from Panama City to South Carolina?

    The most popular flight routes from Panama City to South Carolina are Panama City Tocumen Intl - Charlotte Douglas, Panama City Tocumen Intl - Charleston and Panama City Tocumen Intl - Columbia Metropolitan.

  • Can I find deals for flights from Panama City to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama City to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South Carolina.

  • Can I find deals for business class flights from Panama City to South Carolina?

    Yes. Cheapflights offers flight deals from Panama City to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Panama City to South Carolina (average of $217). Flying from Panama City to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Panama City to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Panama City to South Carolina

Discover the top airline that operate flights from Panama City to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$423Average$501FlexibilityNo cancel feeOn-time71%

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