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$370+ Cheap flights from Iowa to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/28. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — BOG
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
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Cheap flight deals from Iowa to South America

Cheapest flights from Iowa to South America
Explore the most affordable flight options available from Iowa to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:16 pmDSM - LIM
1 stop26h 19mMultiple Airlines
Sun 1/186:04 amLIM - DSM
2 stops38h 19mMultiple Airlines
Deal found 12/14$900
This Copa Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:25 pmOMA - MDE
2 stops15h 26mCopa Airlines
Sat 1/178:37 amMDE - OMA
2 stops15h 30mCopa Airlines
Deal found 12/13$902
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:07 amDSM - LIM
2 stops17h 18mAmerican Airlines
Thu 1/1512:45 amLIM - DSM
2 stops17h 21mAmerican Airlines
Deal found 12/14$996
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1711:15 amDSM - LIM
2 stops36h 35mMultiple Airlines
Wed 3/1810:30 pmLIM - DSM
1 stop24h 58mMultiple Airlines
Deal found 12/14$1,001
This Delta deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:35 amDSM - LIM
2 stops16h 05mDelta
Sun 1/181:30 pmLIM - DSM
2 stops22h 11mDelta
Deal found 12/14$1,020
This United Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:25 pmOMA - MDE
2 stops35h 17mUnited Airlines
Sat 1/1710:45 amMDE - OMA
1 stop12h 36mUnited Airlines
Deal found 12/13$1,070
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2512:15 pmDSM - LIM
1 stop32h 55mMultiple Airlines
Sun 1/186:04 amLIM - DSM
2 stops38h 19mMultiple Airlines
Deal found 12/14$1,074
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/183:11 pmDSM - LIM
1 stop30h 24mMultiple Airlines
Sun 1/186:04 amLIM - DSM
2 stops38h 19mMultiple Airlines
Deal found 12/14$1,129
This FlightHub deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:35 amDSM - LIM
1 stop14h 45mLATAM Airlines
Mon 12/2911:40 pmLIM - DSM
1 stop11h 58mLATAM Airlines
Deal found 12/14$1,194
This Delta deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/212:18 pmDSM - LIM
1 stop13h 42mDelta
Sun 1/181:30 pmLIM - DSM
2 stops22h 11mDelta
Deal found 12/14$1,208
This Delta deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:22 pmOMA - LIM
1 stop25h 58mDelta
Sat 12/278:25 amLIM - OMA
2 stops16h 43mDelta
Deal found 12/13$1,231
This Delta deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/187:00 amOMA - LIM
1 stop21h 00mDelta
Sun 12/2811:40 pmLIM - OMA
1 stop12h 14mDelta
Deal found 12/13$1,235

Find flight deals from Iowa to South America

Keep the following information in mind while searching for Iowa to South America flight deals. Data was last updated December 15, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$380
(Kiwi.com)

One-way from

$370
(Delta)

Popular in

June

Cheapest in

April

Average price

$1,405
Provider with most accurate pricing for Des Moines-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Sao Paulo (SAO) flights.
Search Deals
From Iowa to South America
Search Deals
One-way flight from Iowa to South America
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($279 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($103 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Iowa to South America that are best for you.

Fly from

Iowa

Fly to

South America

Route

Depart

Return

Price

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Sun 2/15

3:32 pm-12:04 am

1 stop31h 32m

Guayaquil Jose Joaquin de Olmedo

Mon 3/2

12:59 am-10:35 am

2 stops34h 36m

$444

OmahaMedellín

OMA - MDE

OMAMDE

Omaha Eppley Airfield

Mon 2/2

6:06 am-10:05 pm

1 stop14h 59m

Medellín Jose Maria Cordova Intl

Thu 2/5

10:45 am-6:54 pm

1 stop9h 09m

$553

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Thu 2/12

3:32 pm-12:04 am

1 stop31h 32m

Guayaquil Jose Joaquin de Olmedo

Sat 2/28

12:59 am-2:18 pm

2 stops14h 19m

$558

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Wed 1/28

6:14 pm-12:21 am

3 stops29h 07m

Guayaquil Jose Joaquin de Olmedo

Tue 2/3

3:30 am-3:40 pm

3 stops37h 10m

$564

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Tue 1/27

6:30 am-1:33 pm

1 stop30h 03m

Barranquilla E Cortissoz

Tue 2/3

2:33 pm-11:29 pm

1 stop9h 56m

$589

Des MoinesLima

DSM - LIM

DSMLIM

Des Moines

Wed 1/28

6:14 pm-10:35 pm

3 stops27h 21m

Lima J Chavez Intl

Wed 2/4

6:04 am-10:46 pm

3 stops41h 42m

$590

Des MoinesBarranquilla

DSM - BAQ

DSMBAQ

Des Moines

Wed 1/28

6:30 am-1:33 pm

1 stop30h 03m

Barranquilla E Cortissoz

Wed 2/4

2:33 pm-11:29 pm

1 stop9h 56m

$595

OmahaMedellín

OMA - MDE

OMAMDE

Omaha Eppley Airfield

Sat 1/17

1:51 pm-2:06 pm

2 stops23h 15m

Medellín Jose Maria Cordova Intl

Tue 1/20

3:10 pm-11:41 am

2 stops21h 31m

$608

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Wed 2/11

8:10 am-11:42 pm

2 stops14h 32m

Guayaquil Jose Joaquin de Olmedo

Tue 3/3

12:20 pm-10:20 pm

2 stops35h 00m

$611

Des MoinesGuayaquil

DSM - GYE

DSMGYE

Des Moines

Wed 2/11

8:10 am-11:42 pm

2 stops14h 32m

Guayaquil Jose Joaquin de Olmedo

Mon 3/2

8:32 am-10:20 pm

2 stops38h 48m

$620

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/14

Showing 1-10 of 41 results
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Best time to book a flight from Iowa to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to South America

What is the cheapest month to book a flight from Iowa to South America?

Currently, February is the cheapest month in which you can book a flight from Iowa to South America (average of $359). Flying from Iowa to South America in November is currently the most expensive (average of $855). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to SA?

Find hourly flight availability from Iowa to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 15, 2025.

It’s typically best to fly out from Iowa to South America in the evening. Doing so could potentially save you 40% on the flight price compared to flying in the morning, which is usually more expensive.

Related info for your journey

Find useful and relevant information for your journey from Iowa to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Iowa to South America?

    For as low as $553, United Airlines can have you in South America from Iowa in 14h 59m. The distance from Iowa to South America is about 2734 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Iowa to South America that include hotel bookings?

    Yes. In addition to deals on Iowa to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to South America.

  • Can I find deals for business class flights from Iowa to South America?

    Yes. Cheapflights offers flight deals from Iowa to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to South America?

    Currently, February is the cheapest month in which you can book a flight from Iowa to South America (average of $359). Flying from Iowa to South America in November is currently the most expensive (average of $855). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Iowa to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Iowa to South America

Discover the top 3 airlines that operate flights from Iowa to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$488Average$940FlexibilityNo cancel feeOn-time71%
DeltaCheapest$503Average$985FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$592Average$978FlexibilityNo cancel feeOn-time81%

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