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South America

$244+ Cheap flights from Greenville (GSP) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/1. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — BOG
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Greenville to South America

Keep the following information in mind while searching for Greenville to South America flight deals. Data was last updated September 17, 2025.

Round-trip from

$422
(Kiwi.com)

One-way from

$244
(Copa Airlines)
From Greenville to South America
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One-way flight from Greenville to South America
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Find flight deals from Greenville to South America

Cheapest flights from Greenville to South America
Explore the most affordable flight options available from Greenville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:17 pmGSP - MDE
2 stops20h 59mMultiple Airlines
Thu 11/206:59 pmMDE - GSP
1 stop17h 38mMultiple Airlines
Deal found 9/15$422
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/318:03 pmGSP - MDE
1 stop18h 01mMultiple Airlines
Fri 11/76:59 pmMDE - GSP
2 stops48h 24mMultiple Airlines
Deal found 9/16$453
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1311:33 amGSP - MDE
2 stops9h 37mAmerican Airlines
Thu 11/207:00 amMDE - GSP
2 stops15h 04mAmerican Airlines
Deal found 9/15$510
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/85:16 pmGSP - BOG
2 stops18h 49mDelta
Thu 11/136:35 pmBOG - GSP
2 stops14h 27mDelta
Deal found 9/16$520
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/208:03 pmGSP - BOG
2 stops21h 41mMultiple Airlines
Mon 11/38:40 amBOG - GSP
1 stop10h 43mMultiple Airlines
Deal found 9/17$525
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1511:34 amGSP - MDE
1 stop12h 05mAmerican Airlines
Sat 11/227:00 amMDE - GSP
1 stop16h 59mAmerican Airlines
Deal found 9/15$526
This FlightHub deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2011:04 amGSP - BOG
2 stops9h 50mLATAM Airlines
Mon 11/310:55 amBOG - GSP
2 stops11h 23mLATAM Airlines
Deal found 9/17$532
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/205:30 amGSP - BOG
1 stop9h 10mDelta
Mon 11/39:00 amBOG - GSP
1 stop7h 41mDelta
Deal found 9/17$533
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/224:56 pmGSP - MDE
1 stop29h 09mUnited Airlines
Sun 11/3010:45 amMDE - GSP
1 stop28h 54mUnited Airlines
Deal found 9/14$537
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/225:30 amGSP - BOG
1 stop14h 45mDelta
Mon 10/276:35 pmBOG - GSP
2 stops17h 12mDelta
Deal found 9/17$543
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/206:00 amGSP - MDE
1 stop15h 15mAmerican Airlines
Tue 10/286:00 amMDE - GSP
1 stop16h 21mAmerican Airlines
Deal found 9/15$546
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/229:35 amGSP - BOG
2 stops20h 19mUnited Airlines
Sun 10/261:30 amBOG - GSP
1 stop19h 29mUnited Airlines
Deal found 9/17$547

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Greenville to South America that are best for you.

Fly from

Greenville

Fly to

South America

Route

Depart

Return

Price

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Thu 11/13

5:17 pm-2:16 pm

2 stops20h 59m

Medellín Jose Maria Cordova Intl

Thu 11/20

6:59 pm-12:37 pm

1 stop17h 38m

$422

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Thu 11/13

11:33 am-9:10 pm

2 stops9h 37m

Medellín Jose Maria Cordova Intl

Thu 11/20

7:00 am-10:04 pm

2 stops15h 04m

$510

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Mon 10/20

8:03 pm-4:44 pm

2 stops21h 41m

Bogotá El Dorado

Mon 11/3

8:40 am-7:23 pm

1 stop10h 43m

$525

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Sat 11/22

4:56 pm-10:05 pm

1 stop29h 09m

Medellín Jose Maria Cordova Intl

Sun 11/30

10:45 am-8:49 pm

2 stops34h 04m

$537

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Wed 3/11

7:45 am-7:30 pm

1 stop12h 45m

Bogotá El Dorado

Fri 3/13

2:55 pm-9:27 am

1 stop17h 32m

$538

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Wed 3/11

7:00 am-10:35 pm

1 stop16h 35m

Bogotá El Dorado

Thu 3/12

1:30 am-9:46 pm

1 stop19h 16m

$538

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Wed 3/11

10:14 am-8:20 pm

2 stops11h 06m

Bogotá El Dorado

Fri 3/13

7:00 am-9:22 pm

2 stops13h 22m

$542

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Wed 10/22

7:52 am-1:40 pm

1 stop6h 48m

Bogotá El Dorado

Mon 10/27

9:00 am-11:55 pm

1 stop13h 55m

$543

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Wed 10/22

5:36 pm-12:00 pm

2 stops19h 24m

Bogotá El Dorado

Mon 10/27

6:35 pm-12:47 pm

2 stops17h 12m

$543

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Fri 1/23

5:38 am-8:52 pm

1 stop15h 14m

Medellín Jose Maria Cordova Intl

Sun 2/8

6:50 am-3:43 pm

1 stop8h 53m

$546

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 56 results
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Best time to book a flight from Greenville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to South America

What is the cheapest month to book a flight from Greenville to South America?

Currently, May is the cheapest month in which you can book a flight from Greenville to South America (average of $359). Flying from Greenville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to SA?

Find hourly flight availability from Greenville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

When flying from Greenville to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated September 17, 2025.
Read through reviews of airlines operating flights from Greenville to South America, such as Delta, LATAM Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Overall

8.0

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Overall

8.0

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,847 reviews
Delta
8.0
Very good
7,957 reviews

Overall

8.0

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Overall

8.0

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Greenville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to South America?

    For a flight from Greenville to South America, you will be flying from Greenville. Greenville (GSP) is just 10.4 mi from the center of the city.

  • How long is the flight from Greenville to South America?

    American Airlines, United Airlines, and LATAM Airlines can get you from Greenville to South America in just under 9h 37m. Your travel time can differ by up to 19h 32m. The distance from Greenville to South America is about 2030 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Greenville to South America one-way?

    To fly one-way, consider booking your trip with Copa Airlines, which is currently one of the cheapest options available, starting at $244. American Airlines flights start at $297 while deals on Delta start at $314 one-way.

  • What are the most popular routes from Greenville to South America?

    The most popular route from Greenville to South America is Greenville - Medellín Jose Maria Cordova Intl. You may also consider Greenville - Bogotá El Dorado or Greenville - Quito Mariscal Sucr.

  • Can I find deals for flights from Greenville to South America that include hotel bookings?

    Yes. In addition to deals on Greenville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to South America.

  • Can I find deals for business class flights from Greenville to South America?

    Yes. Cheapflights offers flight deals from Greenville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to South America?

    Currently, May is the cheapest month in which you can book a flight from Greenville to South America (average of $359). Flying from Greenville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Greenville to South America

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Top 3 airlines flying from Greenville to South America

Discover the top 3 airlines that operate flights from Greenville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$490Average$751FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$502Average$871FlexibilityNo cancel feeOn-time81%
DeltaCheapest$532Average$939FlexibilityNo cancel feeOn-timeN/A

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