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South America

$185+ Cheap flights from Greenville (GSP) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/2. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — BOG
Dec 5 — Dec 121
Fri 12/5
Fri 12/12
1 adult, Economy
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Find flight deals from Greenville to South America

Cheapest flights from Greenville to South America
Explore the most affordable flight options available from Greenville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/234:43 pmGSP - MDE
2 stops32h 45mMultiple Airlines
Thu 1/223:11 pmMDE - GSP
1 stop17h 47mMultiple Airlines
Deal found 11/5$437
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/244:40 pmGSP - MDE
1 stop8h 48mMultiple Airlines
Thu 1/151:00 pmMDE - GSP
1 stop19h 58mMultiple Airlines
Deal found 11/4$449
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/309:33 amGSP - MDE
2 stops52h 41mMultiple Airlines
Wed 1/283:11 pmMDE - GSP
1 stop25h 44mMultiple Airlines
Deal found 11/3$459
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/178:03 pmGSP - MDE
2 stops18h 12mMultiple Airlines
Thu 11/203:14 pmMDE - GSP
1 stop21h 23mMultiple Airlines
Deal found 11/3$466
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/229:34 pmGSP - MDE
2 stops35h 37mMultiple Airlines
Sun 11/301:51 amMDE - GSP
1 stop12h 52mMultiple Airlines
Deal found 11/3$492
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:35 amGSP - BOG
2 stops14h 45mDelta
Fri 12/195:00 amBOG - GSP
2 stops18h 42mDelta
Deal found 11/3$573
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/153:00 pmGSP - BOG
1 stop10h 12mMultiple Airlines
Thu 1/13:05 pmBOG - GSP
1 stop29h 03mMultiple Airlines
Deal found 11/3$588
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/155:10 amGSP - BOG
1 stop7h 30mAmerican Airlines
Wed 3/1112:50 pmBOG - GSP
1 stop9h 49mAmerican Airlines
Deal found 11/3$593
This FlightHub deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/77:52 amGSP - BOG
1 stop6h 33mLATAM Airlines
Mon 11/103:55 pmBOG - GSP
1 stop7h 50mLATAM Airlines
Deal found 11/3$633
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1310:16 amGSP - CTG
1 stop11h 14mAmerican Airlines
Sat 12/204:30 pmCTG - GSP
1 stop7h 57mAmerican Airlines
Deal found 11/4$634
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:30 amGSP - BOG
2 stops11h 15mDelta
Mon 11/1010:55 amBOG - GSP
2 stops11h 39mDelta
Deal found 11/3$638
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/54:56 pmGSP - CTG
2 stops30h 04mUnited Airlines
Sun 11/99:42 amCTG - GSP
2 stops36h 17mUnited Airlines
Deal found 11/5$660

Cheap flight deals from Greenville to South America

Keep the following information in mind while searching for Greenville to South America flight deals. Data was last updated November 5, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$437
(Kiwi.com)

One-way from

$185
(Kiwi.com)
Provider with most accurate pricing for Greenville-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Sao Paulo (SAO) flights.
Search Deals
From Greenville to South America
Search Deals
One-way flight from Greenville to South America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from Greenville to South America that are best for you.

Fly from

Greenville

Fly to

South America

Route

Depart

Return

Price

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Tue 12/23

4:43 pm-1:28 am

2 stops32h 45m

Medellín Jose Maria Cordova Intl

Thu 1/22

3:11 pm-8:58 am

1 stop17h 47m

$437

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Mon 11/17

8:03 pm-2:15 pm

2 stops18h 12m

Medellín Jose Maria Cordova Intl

Thu 11/20

3:14 pm-12:37 pm

1 stop21h 23m

$466

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Fri 1/23

4:39 pm-2:16 pm

2 stops45h 37m

Medellín Jose Maria Cordova Intl

Mon 1/26

6:35 am-3:59 pm

1 stop9h 24m

$495

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Sat 11/22

9:34 pm-6:35 am

3 stops33h 01m

Medellín Jose Maria Cordova Intl

Sun 11/30

1:51 am-2:43 pm

1 stop12h 52m

$504

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Sat 5/2

6:45 am-7:25 pm

1 stop13h 40m

Bogotá El Dorado

Wed 5/6

9:00 am-9:25 pm

1 stop11h 25m

$520

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Sat 2/7

6:30 am-10:05 pm

2 stops15h 35m

Medellín Jose Maria Cordova Intl

Sat 2/21

10:45 am-10:06 am

2 stops23h 21m

$531

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Fri 1/23

5:34 pm-10:05 pm

2 stops28h 31m

Medellín Jose Maria Cordova Intl

Sun 2/8

10:45 am-2:19 pm

2 stops27h 34m

$547

GreenvilleCartagena

GSP - CTG

GSPCTG

Greenville

Tue 3/10

6:50 am-11:00 pm

2 stops17h 10m

Cartagena Rafael Nunez

Fri 3/13

9:42 am-11:11 am

2 stops24h 29m

$569

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Fri 12/5

5:35 am-8:20 pm

2 stops14h 45m

Bogotá El Dorado

Fri 12/19

5:00 am-11:42 pm

2 stops18h 42m

$573

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Mon 12/15

5:10 am-12:40 pm

1 stop7h 30m

Bogotá El Dorado

Wed 3/11

12:50 pm-11:39 pm

1 stop9h 49m

$593

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Showing 1-10 of 52 results
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Best time to book a flight from Greenville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to South America

What is the cheapest month to book a flight from Greenville to South America?

Currently, October is the cheapest month in which you can book a flight from Greenville to South America (average of $96). Flying from Greenville to South America in June is currently the most expensive (average of $426). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to SA?

Find hourly flight availability from Greenville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 5, 2025.

One of the essential ways to save on airfare from Greenville to South America is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 23% on airfare.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated November 5, 2025.
Read through reviews of airlines operating flights from Greenville to South America, such as Delta, LATAM Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,004 reviews

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,004 reviews
Delta
7.9
Good
8,004 reviews

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,874 reviews
Delta
7.9
Good
8,004 reviews

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,039 reviews
Delta
7.9
Good
8,004 reviews

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to South America?

    For a flight from Greenville to South America, you will be flying from Greenville. Greenville (GSP) is just 10.4 mi from the center of the city.

  • How long is the flight from Greenville to South America?

    Delta, United Airlines, and LATAM Airlines can get you from Greenville to South America in just under 13h 40m. Your travel time can differ by up to 4h 20m. The distance from Greenville to South America is about 2148 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Greenville to South America?

    The most popular route from Greenville to South America is Greenville - Medellín Jose Maria Cordova Intl. You may also consider Greenville - Lima J Chavez Intl or Greenville - Bogotá El Dorado.

  • Can I find deals for flights from Greenville to South America that include hotel bookings?

    Yes. In addition to deals on Greenville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to South America.

  • Can I find deals for business class flights from Greenville to South America?

    Yes. Cheapflights offers flight deals from Greenville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to South America?

    Currently, October is the cheapest month in which you can book a flight from Greenville to South America (average of $96). Flying from Greenville to South America in June is currently the most expensive (average of $426). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Greenville to South America

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Top 3 airlines flying from Greenville to South America

Discover the top 3 airlines that operate flights from Greenville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$502Average$876FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$502Average$899FlexibilityNo cancel feeOn-time71%
DeltaCheapest$532Average$923FlexibilityNo cancel feeOn-timeN/A

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