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South America

$161+ Cheap flights from Greenville (GSP) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/1. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — BOG
Feb 6 — Feb 131
Fri 2/6
Fri 2/13
1 adult, Economy
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Cheap flight deals from Greenville to South America

Keep the following information in mind while searching for Greenville to South America flight deals. Data was last updated January 7, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$418
(Kiwi.com)

One-way from

$161
(Kiwi.com)
Provider with most accurate pricing for Greenville-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Greenville-Sao Paulo (SAO) flights.
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From Greenville to South America
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One-way flight from Greenville to South America
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Find flight deals from Greenville to South America

Cheapest flights from Greenville to South America
Explore the most affordable flight options available from Greenville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 7, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:22 pmGSP - CTG
1 stop18h 48mMultiple Airlines
Fri 2/275:49 pmCTG - GSP
2 stops46h 34mMultiple Airlines
Deal found 1/6$418
This Kiwi.com deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/15:45 pmGSP - MDE
2 stops30h 09mMultiple Airlines
Sun 2/81:00 pmMDE - GSP
1 stop19h 58mMultiple Airlines
Deal found 1/5$424
This Kiwi.com deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/195:17 pmGSP - MDE
2 stops42h 59mMultiple Airlines
Thu 2/261:00 pmMDE - GSP
1 stop28h 59mMultiple Airlines
Deal found 1/5$428
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/166:22 pmGSP - MDE
1 stop19h 51mMultiple Airlines
Mon 2/236:55 amMDE - GSP
2 stops10h 37mMultiple Airlines
Deal found 1/6$453
This Kiwi.com deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/155:17 pmGSP - MDE
1 stop20h 56mMultiple Airlines
Sun 3/13:15 pmMDE - GSP
1 stop26h 44mMultiple Airlines
Deal found 1/5$458
This Delta deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/286:50 amGSP - BOG
1 stop12h 40mDelta
Wed 2/46:35 pmBOG - GSP
2 stops19h 28mDelta
Deal found 1/4$474
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:24 pmGSP - CTG
2 stops19h 06mAmerican Airlines
Fri 2/272:30 pmCTG - GSP
2 stops18h 08mAmerican Airlines
Deal found 1/6$479
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:26 pmGSP - BOG
1 stop16h 47mAmerican Airlines
Sat 3/287:05 amBOG - GSP
1 stop16h 16mAmerican Airlines
Deal found 1/6$484
This Kiwi.com deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/15:45 pmGSP - MDE
2 stops27h 06mMultiple Airlines
Sat 2/143:15 pmMDE - GSP
1 stop25h 12mMultiple Airlines
Deal found 1/5$484
This American Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/1312:06 pmGSP - BOG
1 stop11h 24mAmerican Airlines
Sun 2/228:00 amBOG - GSP
1 stop16h 22mAmerican Airlines
Deal found 1/5$494
This Kiwi.com deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/169:48 amGSP - MDE
1 stop28h 27mMultiple Airlines
Sat 1/3110:45 pmMDE - GSP
2 stops34h 13mMultiple Airlines
Deal found 1/5$498
This American Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:45 amGSP - CTG
1 stop6h 42mAmerican Airlines
Sun 3/153:15 pmCTG - GSP
1 stop26h 41mAmerican Airlines
Deal found 1/5$499

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
Use the filters below to find and compare flights from Greenville to South America that are best for you.

Fly from

Greenville

Fly to

South America

Route

Depart

Return

Price

GreenvilleCartagena

GSP - CTG

GSPCTG

Greenville

Fri 2/20

6:22 pm-1:10 pm

1 stop18h 48m

Cartagena Rafael Nunez

Fri 2/27

5:49 pm-4:23 pm

2 stops46h 34m

$418

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Sun 2/1

5:45 pm-11:54 pm

2 stops30h 09m

Medellín Jose Maria Cordova Intl

Sun 2/8

1:00 pm-8:58 am

1 stop19h 58m

$424

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Thu 2/19

5:17 pm-12:16 pm

2 stops42h 59m

Medellín Jose Maria Cordova Intl

Thu 2/26

1:00 pm-5:59 pm

1 stop28h 59m

$428

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Wed 1/28

5:40 am-7:30 pm

1 stop13h 50m

Bogotá El Dorado

Wed 2/4

9:00 am-4:17 pm

1 stop7h 17m

$474

GreenvilleCartagena

GSP - CTG

GSPCTG

Greenville

Fri 2/20

6:24 pm-1:30 pm

2 stops19h 06m

Cartagena Rafael Nunez

Fri 2/27

2:30 pm-8:38 am

2 stops18h 08m

$479

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Sun 3/22

7:26 pm-11:13 am

1 stop16h 47m

Bogotá El Dorado

Sat 3/28

7:05 am-12:21 am

1 stop16h 16m

$484

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Sun 2/1

5:45 pm-8:51 pm

2 stops27h 06m

Medellín Jose Maria Cordova Intl

Sat 2/14

3:15 pm-4:27 pm

1 stop25h 12m

$484

GreenvilleCartagena

GSP - CTG

GSPCTG

Greenville

Wed 3/11

6:45 am-12:27 pm

1 stop6h 42m

Cartagena Rafael Nunez

Sun 3/15

3:15 pm-6:56 pm

1 stop26h 41m

$499

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Sun 3/1

5:13 pm-1:55 pm

2 stops20h 42m

Medellín Jose Maria Cordova Intl

Sun 3/15

1:00 pm-5:15 pm

1 stop27h 15m

$507

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Sun 1/25

7:46 pm-2:25 pm

1 stop18h 39m

Bogotá El Dorado

Thu 1/29

9:00 am-11:50 pm

1 stop14h 50m

$520

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/4

Showing 1-10 of 59 results
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Best time to book a flight from Greenville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to South America

What is the cheapest month to book a flight from Greenville to South America?

Currently, October is the cheapest month in which you can book a flight from Greenville to South America (average of $96). Flying from Greenville to South America in June is currently the most expensive (average of $426). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated January 7, 2026.
Read through reviews of airlines operating flights from Greenville to South America, such as Delta, LATAM Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,021 reviews

Overall

7.9

Food

7.2

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,021 reviews
Delta
7.9
Good
8,021 reviews

Overall

7.9

Food

7.2

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,897 reviews
Delta
7.9
Good
8,021 reviews

Overall

7.9

Food

7.2

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,090 reviews
Delta
7.9
Good
8,021 reviews

Overall

7.9

Food

7.2

Comfort

7.9

Entertainment

7.8

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to South America?

    For a flight from Greenville to South America, you will be flying from Greenville. Greenville (GSP) is just 10.4 mi from the center of the city.

  • How long is the flight from Greenville to South America?

    Delta, American Airlines, and LATAM Airlines can get you from Greenville to South America in just under 12h 40m. Your travel time can differ by up to 6h 26m. The distance from Greenville to South America is about 2148 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Greenville to South America?

    The most popular route from Greenville to South America is Greenville - Lima J Chavez Intl. You may also consider Greenville - Quito Mariscal Sucr or Greenville - Medellín Jose Maria Cordova Intl.

  • Can I find deals for flights from Greenville to South America that include hotel bookings?

    Yes. In addition to deals on Greenville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to South America.

  • Can I find deals for business class flights from Greenville to South America?

    Yes. Cheapflights offers flight deals from Greenville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to South America?

    Currently, October is the cheapest month in which you can book a flight from Greenville to South America (average of $96). Flying from Greenville to South America in June is currently the most expensive (average of $426). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Greenville to South America

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Top 3 airlines flying from Greenville to South America

Discover the top 3 airlines that operate flights from Greenville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$502Average$801FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$502Average$858FlexibilityNo cancel feeOn-time71%
DeltaCheapest$532Average$900FlexibilityNo cancel feeOn-timeN/A

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