$110+ Cheap flights from Des Moines to San Francisco (DSM - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/20. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Aug 28 — Sep 41
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to San Francisco
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Cheapest flights from Des Moines to San FranciscoExplore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2026.
Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:50 pm
DSM
- SFO
1 stop20h 46m
Multiple Airlines
Thu 8/273:38 pm
SFO
- DSM
1 stop25h 10m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SFO
1 stop14h 19m
Multiple Airlines
Wed 8/268:56 pm
SFO
- DSM
1 stop22h 04m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:38 pm
DSM
- SFO
1 stop15h 47m
Multiple Airlines
Thu 9/310:59 pm
SFO
- DSM
1 stop10h 11m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:38 pm
DSM
- SFO
1 stop15h 47m
Multiple Airlines
Thu 8/273:38 pm
SFO
- DSM
1 stop25h 10m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SFO
1 stop14h 19m
Multiple Airlines
Thu 8/278:56 pm
SFO
- DSM
1 stop19h 52m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm
DSM
- SFO
1 stop18h 58m
Multiple Airlines
Thu 10/110:24 pm
SFO
- DSM
1 stop10h 33m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:50 pm
DSM
- SFO
1 stop24h 06m
Multiple Airlines
Thu 9/310:59 pm
SFO
- DSM
1 stop10h 11m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1410:06 pm
DSM
- SFO
1 stop20h 30m
Multiple Airlines
Thu 8/2711:00 am
SFO
- DSM
1 stop8h 00m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:42 pm
DSM
- SFO
1 stop19h 32m
Multiple Airlines
Tue 10/67:11 pm
SFO
- DSM
1 stop16h 41m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1410:06 pm
DSM
- SFO
1 stop20h 30m
Multiple Airlines
Mon 8/2411:00 am
SFO
- DSM
1 stop6h 48m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/279:56 pm
DSM
- SFO
1 stop14h 59m
Multiple Airlines
Thu 10/110:24 pm
SFO
- DSM
1 stop10h 33m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm
DSM
- SFO
1 stop18h 58m
Multiple Airlines
Tue 9/297:11 pm
SFO
- DSM
1 stop16h 41m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$217
Best flights from Des Moines to San FranciscoDiscover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2026.
Discover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2026.
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/261:21 pm
DSM
- SFO
1 stop7h 51m
United Airlines
Wed 9/212:35 pm
SFO
- DSM
1 stop5h 51m
United Airlines
Deal found 7/25![United Airlines logo]()
$301
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:59 am
DSM
- SFO
1 stop8h 19m
Delta
Wed 9/26:13 am
SFO
- DSM
1 stop5h 51m
Delta
Deal found 7/26![Delta logo]()
$301
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/123:05 pm
DSM
- SFO
1 stop7h 35m
Southwest
Sat 9/196:25 am
SFO
- DSM
2 stops7h 45m
Southwest
Deal found 7/28![Southwest logo]()
$306
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/267:15 am
DSM
- SFO
1 stop5h 35m
Southwest
Wed 9/210:40 am
SFO
- DSM
2 stops8h 20m
Southwest
Deal found 7/25![Southwest logo]()
$306
This Delta deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2912:30 pm
DSM
- SFO
1 stop7h 43m
Delta
Wed 9/26:13 am
SFO
- DSM
1 stop5h 51m
Delta
Deal found 7/25![Delta logo]()
$311
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/267:15 am
DSM
- SFO
2 stops8h 00m
Southwest
Mon 8/315:10 am
SFO
- DSM
1 stop8h 00m
Southwest
Deal found 7/26![Southwest logo]()
$306
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/167:15 am
DSM
- SFO
2 stops8h 00m
Southwest
Mon 9/2110:25 am
SFO
- DSM
2 stops8h 55m
Southwest
Deal found 7/28![Southwest logo]()
$311
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/292:46 pm
DSM
- SFO
1 stop7h 46m
Delta
Wed 10/74:50 pm
SFO
- DSM
2 stops15h 21m
Delta
Deal found 7/27![Delta logo]()
$356
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:15 am
DSM
- SFO
2 stops8h 00m
Southwest
Tue 9/110:40 am
SFO
- DSM
2 stops8h 20m
Southwest
Deal found 7/28![Southwest logo]()
$311
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/102:30 pm
DSM
- SFO
1 stop9h 05m
Southwest
Wed 10/1410:20 am
SFO
- DSM
2 stops8h 15m
Southwest
Deal found 7/26![Southwest logo]()
$312
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/194:50 pm
DSM
- SFO
1 stop6h 40m
Southwest
Sat 9/266:25 am
SFO
- DSM
2 stops7h 45m
Southwest
Deal found 7/24![Southwest logo]()
$318
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:25 pm
DSM
- SFO
2 stops8h 05m
Southwest
Mon 8/3110:50 am
SFO
- DSM
2 stops8h 25m
Southwest
Deal found 7/27![Southwest logo]()
$361
Last-minute flights from Des Moines to San FranciscoDiscover last-minute flight deals from Des Moines to San Francisco. Data last updated July 29, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Francisco. Data last updated July 29, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1410:06 pm
DSM
- SFO
1 stop20h 30m
Multiple Airlines
Thu 8/2711:00 am
SFO
- DSM
1 stop8h 00m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1410:06 pm
DSM
- SFO
1 stop20h 30m
Multiple Airlines
Mon 8/2411:00 am
SFO
- DSM
1 stop6h 48m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SFO
1 stop14h 19m
Multiple Airlines
Wed 8/268:56 pm
SFO
- DSM
1 stop22h 04m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SFO
1 stop14h 19m
Multiple Airlines
Thu 8/278:56 pm
SFO
- DSM
1 stop19h 52m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SFO
1 stop14h 19m
Multiple Airlines
Mon 8/2411:00 am
SFO
- DSM
1 stop6h 48m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SFO
1 stop14h 19m
Multiple Airlines
Thu 8/2011:00 am
SFO
- DSM
1 stop8h 00m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SFO
1 stop14h 19m
Multiple Airlines
Wed 8/198:56 pm
SFO
- DSM
1 stop22h 04m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:50 pm
DSM
- SFO
1 stop20h 46m
Multiple Airlines
Thu 8/273:38 pm
SFO
- DSM
1 stop25h 10m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$193
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:50 pm
DSM
- SFO
1 stop24h 06m
Multiple Airlines
Thu 9/310:59 pm
SFO
- DSM
1 stop10h 11m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:38 pm
DSM
- SFO
1 stop15h 47m
Multiple Airlines
Thu 9/310:59 pm
SFO
- DSM
1 stop10h 11m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:38 pm
DSM
- SFO
1 stop15h 47m
Multiple Airlines
Thu 8/273:38 pm
SFO
- DSM
1 stop25h 10m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:38 pm
DSM
- SFO
1 stop26h 18m
Multiple Airlines
Thu 9/310:59 pm
SFO
- DSM
1 stop10h 11m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$225
One-way flights from Des Moines to San FranciscoSearch for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 29, 2026.
Search for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/209:56 pm
DSM
- SFO
1 stop14h 59m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:38 pm
DSM
- SFO
1 stop15h 05m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$124
This Priceline deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:19 pm
DSM
- SFO
1 stop6h 26m
Frontier
Deal found 7/27![Frontier logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:16 pm
DSM
- SFO
1 stop23h 01m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$133
This Frontier deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/42:19 pm
DSM
- SFO
1 stop11h 59m
Frontier
Deal found 7/26![Frontier logo]()
$137
This CheapOair deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:29 am
DSM
- SFO
1 stop25h 18m
Frontier
Deal found 7/27![Frontier logo]()
$142
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:55 am
DSM
- SFO
1 stop6h 07m
Delta
Deal found 7/26![Delta logo]()
$151
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/12:00 pm
DSM
- SFO
2 stops9h 05m
Southwest
Deal found 7/28![Southwest logo]()
$156
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/139:44 pm
DSM
- SFO
1 stop24h 26m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$181
This Orbitz deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:19 pm
DSM
- SFO
1 stop11h 59m
Frontier
Deal found 7/24![Frontier logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/189:00 am
DSM
- SFO
2 stops17h 18m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$187
Find flight deals from Des Moines to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $193 (Kiwi.com) |
One-way from | $110 (Kiwi.com) |
Popular in | June |
Cheapest in | February |
Average price | $506 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 8/26
1:21 pm-7:12 pm
1 stop7h 51m
San Francisco
Wed 9/2
12:35 pm-8:26 pm
1 stop5h 51m
$301
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 8/26
10:59 am-5:18 pm
1 stop8h 19m
San Francisco
Wed 9/2
6:13 am-2:04 pm
1 stop5h 51m
$301
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sat 9/12
3:05 pm-8:40 pm
1 stop7h 35m
San Francisco
Sat 9/19
6:25 am-4:10 pm
2 stops7h 45m
$306
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 8/26
7:15 am-10:50 am
1 stop5h 35m
San Francisco
Wed 9/2
10:40 am-9:00 pm
2 stops8h 20m
$306
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 8/26
7:15 am-1:15 pm
2 stops8h 00m
San Francisco
Mon 8/31
5:10 am-3:10 pm
1 stop8h 00m
$306
Quickest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sat 8/29
12:30 pm-6:13 pm
1 stop7h 43m
San Francisco
Wed 9/2
6:13 am-2:04 pm
1 stop5h 51m
$311
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 9/16
7:15 am-1:15 pm
2 stops8h 00m
San Francisco
Mon 9/21
10:25 am-9:20 pm
2 stops8h 55m
$311
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Tue 8/25
7:15 am-1:15 pm
2 stops8h 00m
San Francisco
Tue 9/1
10:40 am-9:00 pm
2 stops8h 20m
$311
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sat 10/10
2:30 pm-9:35 pm
1 stop9h 05m
San Francisco
Wed 10/14
10:20 am-8:35 pm
2 stops8h 15m
$312
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sat 9/19
4:50 pm-9:30 pm
1 stop6h 40m
San Francisco
Sat 9/26
6:25 am-4:10 pm
2 stops7h 45m
$318
Showing 1-10 of 23 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Francisco in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Des Moines with our price prediction graph.
DSM-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Francisco
Prices
Delays
More
How far ahead should I book a flight from Des Moines to San Francisco?
Booking 26 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Des Moines to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Des Moines to San Francisco (average of $367). Flying from Des Moines to San Francisco in June is currently the most expensive (average of $566). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Francisco?
Airfare is below average for this route at the moment.
Des Moines to San Francisco flights typically cost between $365 and $553 in August.The cheapest round-trip price found within the last 5 days was $193 on Multiple Airlines (Aug 23-Aug 27).
How often are flights from Des Moines to San Francisco delayed?
About 33% of weekly flights between Des Moines and San Francisco have experienced delays in the past year, with the average delay time being 40 minutes.
What is the most punctual flight time for Des Moines to San Francisco flights?
Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What’s the top layover airport for flights from Des Moines to San Francisco?
Share of 1-stop round-trip flights from Des Moines to San Francisco chosen by Cheapflights users in the past 12 months, using the same layover each way.
Denver (DEN) – chosen by Cheapflights users on 75% of 1-stop itineraries from Des Moines to San Francisco on Cheapflights.
What’s the cheapest layover airport for flights from Des Moines to San Francisco?
Average round-trip fare for 1-stop flights from Des Moines to San Francisco, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Denver (DEN) is the most affordable 1-stop option, with an average round-trip price of $298.
What’s the fastest layover option from Des Moines to San Francisco?
Shortest average travel time for 1-stop one-way flights from Des Moines to San Francisco, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 5h 41m.
Which airport typically offers the quickest layover for flights from Des Moines to San Francisco?
Average layover duration for 1-stop one-way flights from Des Moines to San Francisco, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 03m.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated July 29, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Fairfield
Emeryville
Roseville
Burlingame
Rancho Cordova
San Bruno
Cupertino
Newark
Hayward
San Ramon
Redwood City
San Carlos
Turlock
Vallejo
San Lorenzo
Davis
Vacaville
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Des Moines and San Francisco flights
Browse other Des Moines and San Francisco flight options. Last updated on July 29, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on July 29, 2026.
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Top 5 airlines flying from Des Moines to San Francisco
Discover the top 5 airlines that operate flights from Des Moines to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$120 | Average$297 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$253 | Average$502 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$274 | Average$502 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$336 | Average$465 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$344 | Average$489 | FlexibilityNo cancel fee | On-time63% |