$106+ Cheap flights from Des Moines to San Francisco (DSM - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/17. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
May 6 — May 131
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to San FranciscoExplore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 6, 2026.
Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 6, 2026.
This Frontier deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Mon 6/16:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 4/3![Frontier logo]()
$210
This CheapOair deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- SFO
1 stop19h 45m
Frontier
Tue 6/212:52 pm
SFO
- DSM
1 stop22h 39m
Frontier
Deal found 4/1![Frontier logo]()
$221
This Expedia deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- SFO
1 stop12h 23m
Frontier
Mon 5/46:00 am
SFO
- DSM
1 stop11h 38m
Frontier
Deal found 4/3![Frontier logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SFO
1 stop14h 21m
Multiple Airlines
Thu 8/2010:50 pm
SFO
- DSM
1 stop17h 58m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:16 pm
DSM
- SFO
2 stops20h 33m
Multiple Airlines
Tue 6/910:50 pm
SFO
- DSM
1 stop12h 05m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$238
This CheapOair deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- SFO
1 stop12h 23m
Frontier
Thu 5/712:52 pm
SFO
- DSM
1 stop22h 39m
Frontier
Deal found 4/1![Frontier logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/59:56 pm
DSM
- SFO
1 stop12h 53m
Multiple Airlines
Tue 6/910:50 pm
SFO
- DSM
1 stop12h 05m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SFO
1 stop14h 21m
Multiple Airlines
Sat 8/225:26 pm
SFO
- DSM
1 stop22h 17m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SFO
1 stop14h 21m
Multiple Airlines
Sun 8/233:11 pm
SFO
- DSM
1 stop26h 37m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1010:13 pm
DSM
- SFO
1 stop12h 33m
Multiple Airlines
Tue 7/1410:50 pm
SFO
- DSM
1 stop12h 09m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$274
Best flights from Des Moines to San FranciscoDiscover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 6, 2026.
Discover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 6, 2026.
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/92:45 pm
DSM
- SFO
1 stop7h 57m
Delta
Tue 6/164:48 pm
SFO
- DSM
2 stops15h 26m
Delta
Deal found 4/1![Delta logo]()
$392
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:50 am
DSM
- SFO
2 stops7h 45m
Southwest
Thu 5/76:20 am
SFO
- DSM
2 stops10h 15m
Southwest
Deal found 4/2![Southwest logo]()
$409
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/12:35 pm
DSM
- SFO
1 stop9h 00m
Delta
Mon 9/76:15 am
SFO
- DSM
1 stop5h 52m
Delta
Deal found 4/1![Delta logo]()
$425
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/22:40 pm
DSM
- SFO
2 stops8h 40m
Southwest
Wed 9/95:50 am
SFO
- DSM
2 stops9h 55m
Southwest
Deal found 4/1![Southwest logo]()
$435
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/12:35 pm
DSM
- SFO
1 stop9h 00m
Delta
Fri 9/1112:40 am
SFO
- DSM
1 stop7h 35m
Delta
Deal found 4/5![Delta logo]()
$425
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/142:25 pm
DSM
- SFO
1 stop7h 05m
Southwest
Sat 8/228:00 am
SFO
- DSM
1 stop9h 25m
Southwest
Deal found 4/5![Southwest logo]()
$467
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/284:23 pm
DSM
- SFO
2 stops9h 14m
Delta
Tue 5/56:20 am
SFO
- DSM
1 stop7h 21m
Delta
Deal found 4/5![Delta logo]()
$453
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/126:10 am
DSM
- SFO
2 stops8h 50m
Southwest
Mon 6/1511:00 am
SFO
- DSM
2 stops9h 20m
Southwest
Deal found 4/5![Southwest logo]()
$477
This Delta deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:00 am
DSM
- SFO
2 stops10h 59m
Delta
Wed 5/611:59 pm
SFO
- DSM
1 stop8h 17m
Delta
Deal found 4/3![Delta logo]()
$453
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:35 pm
DSM
- SFO
1 stop6h 00m
Delta
Mon 9/74:15 pm
SFO
- DSM
2 stops16h 00m
Delta
Deal found 4/5![Delta logo]()
$468
Last-minute flights from Des Moines to San FranciscoDiscover last-minute flight deals from Des Moines to San Francisco. Data last updated April 6, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Francisco. Data last updated April 6, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:14 pm
DSM
- SFO
1 stop6h 14m
Frontier
Thu 4/1611:56 am
SFO
- DSM
1 stop23h 13m
Frontier
Deal found 4/2![Frontier logo]()
$291
This CheapOair deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:04 pm
DSM
- SFO
1 stop12h 23m
Frontier
Thu 4/2311:56 am
SFO
- DSM
1 stop23h 13m
Frontier
Deal found 4/2![Frontier logo]()
$311
This Expedia deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- SFO
1 stop12h 23m
Frontier
Mon 5/46:00 am
SFO
- DSM
1 stop11h 38m
Frontier
Deal found 4/3![Frontier logo]()
$230
This CheapOair deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- SFO
1 stop12h 23m
Frontier
Thu 5/712:52 pm
SFO
- DSM
1 stop22h 39m
Frontier
Deal found 4/1![Frontier logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/19:45 am
DSM
- SFO
2 stops39h 40m
Multiple Airlines
Mon 5/46:00 am
SFO
- DSM
1 stop11h 38m
Multiple Airlines
Deal found 4/3![Multiple Airlines logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
- SFO
1 stop30h 00m
Multiple Airlines
Mon 5/116:00 am
SFO
- DSM
2 stops14h 57m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$277
This Frontier deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Mon 6/16:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 4/3![Frontier logo]()
$210
This CheapOair deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- SFO
1 stop19h 45m
Frontier
Tue 6/212:52 pm
SFO
- DSM
1 stop22h 39m
Frontier
Deal found 4/1![Frontier logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- SFO
2 stops22h 22m
Multiple Airlines
Tue 6/210:40 pm
SFO
- DSM
1 stop12h 15m
Multiple Airlines
Deal found 4/1![Multiple Airlines logo]()
$305
One-way flights from Des Moines to San FranciscoSearch for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated April 6, 2026.
Search for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated April 6, 2026.
This Expedia deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:04 pm
DSM
- SFO
1 stop12h 23m
Frontier
Deal found 4/1![Frontier logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:17 pm
DSM
- SFO
1 stop24h 32m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$112
This Frontier deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Deal found 4/2![Frontier logo]()
$131
This Frontier deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/152:16 pm
DSM
- SFO
1 stop12h 06m
Frontier
Deal found 4/4![Frontier logo]()
$132
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/299:56 pm
DSM
- SFO
2 stops22h 31m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$135
This Priceline deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/292:16 pm
DSM
- SFO
1 stop8h 34m
Frontier
Deal found 4/5![Frontier logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3110:26 pm
DSM
- SFO
2 stops25h 29m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/239:33 pm
DSM
- SFO
1 stop13h 13m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$179
Find flight deals from Des Moines to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $210 (Frontier) |
One-way from | $106 (Expedia) |
Popular in | March |
Cheapest in | February |
Average price | $427 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 6, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Tue 6/9
2:45 pm-8:42 pm
1 stop7h 57m
San Francisco
Tue 6/16
4:48 pm-10:14 am
2 stops15h 26m
$392
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 4/30
6:50 am-12:35 pm
2 stops7h 45m
San Francisco
Thu 5/7
6:20 am-6:35 pm
2 stops10h 15m
$409
Quickest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Tue 9/1
2:35 pm-9:35 pm
1 stop9h 00m
San Francisco
Mon 9/7
6:15 am-2:07 pm
1 stop5h 52m
$425
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Tue 9/1
2:35 pm-9:35 pm
1 stop9h 00m
San Francisco
Fri 9/11
12:40 am-10:15 am
1 stop7h 35m
$425
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 9/2
2:40 pm-9:20 pm
2 stops8h 40m
San Francisco
Wed 9/9
5:50 am-5:45 pm
2 stops9h 55m
$435
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Tue 4/28
4:23 pm-11:37 pm
2 stops9h 14m
San Francisco
Tue 5/5
6:20 am-3:41 pm
1 stop7h 21m
$453
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Tue 4/28
7:00 am-3:59 pm
2 stops10h 59m
San Francisco
Wed 5/6
11:59 pm-10:16 am
1 stop8h 17m
$453
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Fri 8/14
2:25 pm-7:30 pm
1 stop7h 05m
San Francisco
Sat 8/22
8:00 am-7:25 pm
1 stop9h 25m
$467
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 8/26
5:35 pm-9:35 pm
1 stop6h 00m
San Francisco
Mon 9/7
4:15 pm-10:15 am
2 stops16h 00m
$468
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Fri 6/12
6:10 am-1:00 pm
2 stops8h 50m
San Francisco
Mon 6/15
11:00 am-10:20 pm
2 stops9h 20m
$477
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Francisco in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Des Moines with our price prediction graph.
DSM-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Francisco
Prices
Delays
More
How far ahead should I book a flight from Des Moines to San Francisco?
Use this chart to determine the optimal time to book a round-trip flight from Des Moines to San Francisco. Price data was last updated on April 3, 2026.
Booking 58 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Des Moines to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Des Moines to San Francisco (average of $150). Flying from Des Moines to San Francisco in March is currently the most expensive (average of $322). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Francisco?
How often are flights from Des Moines to San Francisco delayed?
About 0% of weekly flights between Des Moines and San Francisco have experienced delays in the past year, with the average delay time being 0 minutes.
What is the most punctual flight time for Des Moines to San Francisco flights?
Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What’s the top layover airport for flights from Des Moines to San Francisco?
Share of 1-stop round-trip flights from Des Moines to San Francisco chosen by Cheapflights users in the past 12 months, using the same layover each way.
Dallas (DFW) – chosen by Cheapflights users on 50% of 1-stop itineraries from Des Moines to San Francisco on Cheapflights.
What’s the cheapest layover airport for flights from Des Moines to San Francisco?
Average round-trip fare for 1-stop flights from Des Moines to San Francisco, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $381.
What’s the fastest layover option from Des Moines to San Francisco?
Shortest average travel time for 1-stop one-way flights from Des Moines to San Francisco, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 5h 40m.
Which airport typically offers the quickest layover for flights from Des Moines to San Francisco?
Average layover duration for 1-stop one-way flights from Des Moines to San Francisco, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 05m.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated April 6, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Top 5 airlines flying from Des Moines to San Francisco
Discover the top 5 airlines that operate flights from Des Moines to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$158 | Average$258 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$265 | Average$369 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$321 | Average$499 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$334 | Average$414 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$336 | Average$466 | FlexibilityNo cancel fee | On-time63% |