$111+ Cheap flights from Des Moines to San Francisco (DSM - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/29. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Jun 9 — Jun 161
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to San FranciscoExplore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 10, 2026.
Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 10, 2026.
This Frontier deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/292:19 pm
DSM
- SFO
1 stop11h 59m
Frontier
Wed 8/56:00 am
SFO
- DSM
1 stop5h 34m
Frontier
Deal found 5/6![Frontier logo]()
$210
This Frontier deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/292:19 pm
DSM
- SFO
1 stop11h 59m
Frontier
Fri 8/76:00 am
SFO
- DSM
1 stop5h 34m
Frontier
Deal found 5/6![Frontier logo]()
$230
This Frontier deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- SFO
1 stop23h 27m
Frontier
Tue 6/1612:38 pm
SFO
- DSM
1 stop22h 53m
Frontier
Deal found 5/7![Frontier logo]()
$232
This Expedia deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Mon 6/16:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/6![Frontier logo]()
$244
This Frontier deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Wed 6/36:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/5![Frontier logo]()
$250
This Frontier deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/292:26 pm
DSM
- SFO
1 stop12h 01m
Frontier
Tue 7/712:33 pm
SFO
- DSM
1 stop23h 01m
Frontier
Deal found 5/6![Frontier logo]()
$251
This Frontier deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Mon 6/16:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/9![Frontier logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:16 pm
DSM
- SFO
2 stops31h 20m
Multiple Airlines
Tue 6/910:58 pm
SFO
- DSM
1 stop11h 57m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$257
This Expedia deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- SFO
1 stop23h 31m
Frontier
Mon 6/86:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/8![Frontier logo]()
$270
This Frontier deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Wed 6/106:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/5![Frontier logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:36 pm
DSM
- SFO
1 stop13h 13m
Multiple Airlines
Tue 6/910:58 pm
SFO
- DSM
1 stop11h 57m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$280
Best flights from Des Moines to San FranciscoDiscover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 10, 2026.
Discover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 10, 2026.
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:00 pm
DSM
- SFO
1 stop5h 25m
Southwest
Tue 6/1610:25 am
SFO
- DSM
2 stops9h 15m
Southwest
Deal found 5/8![Southwest logo]()
$400
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/282:45 pm
DSM
- SFO
1 stop8h 12m
Delta
Sun 8/212:12 am
SFO
- DSM
1 stop8h 06m
Delta
Deal found 5/5![Delta logo]()
$431
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:50 pm
DSM
- SFO
1 stop7h 55m
United Airlines
Thu 6/1110:35 pm
SFO
- DSM
1 stop9h 55m
United Airlines
Deal found 5/9![United Airlines logo]()
$531
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:55 pm
DSM
- SFO
2 stops7h 40m
Southwest
Mon 6/85:10 am
SFO
- DSM
1 stop5h 40m
Southwest
Deal found 5/8![Southwest logo]()
$404
This Southwest deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/243:45 pm
DSM
- SFO
2 stops9h 40m
Southwest
Wed 7/15:50 am
SFO
- DSM
2 stops10h 30m
Southwest
Deal found 5/9![Southwest logo]()
$405
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/210:54 am
DSM
- SFO
1 stop8h 21m
Delta
Sun 7/56:00 am
SFO
- DSM
1 stop6h 05m
Delta
Deal found 5/5![Delta logo]()
$467
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:00 pm
DSM
- SFO
1 stop5h 25m
Southwest
Fri 6/1211:40 pm
SFO
- DSM
1 stop9h 55m
Southwest
Deal found 5/5![Southwest logo]()
$436
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:10 am
DSM
- SFO
2 stops7h 10m
Southwest
Sun 7/195:30 am
SFO
- DSM
1 stop8h 05m
Southwest
Deal found 5/8![Southwest logo]()
$472
This Southwest deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:10 am
DSM
- SFO
2 stops8h 50m
Southwest
Mon 7/209:45 am
SFO
- DSM
2 stops10h 35m
Southwest
Deal found 5/9![Southwest logo]()
$477
This Southwest deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:10 am
DSM
- SFO
2 stops9h 00m
Southwest
Sat 6/277:05 am
SFO
- DSM
2 stops12h 50m
Southwest
Deal found 5/6![Southwest logo]()
$483
This Southwest deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:10 am
DSM
- SFO
2 stops7h 50m
Southwest
Fri 8/78:30 am
SFO
- DSM
2 stops10h 45m
Southwest
Deal found 5/8![Southwest logo]()
$499
This Southwest deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:45 pm
DSM
- SFO
2 stops10h 25m
Southwest
Mon 6/812:00 pm
SFO
- DSM
2 stops8h 20m
Southwest
Deal found 5/10![Southwest logo]()
$550
Last-minute flights from Des Moines to San FranciscoDiscover last-minute flight deals from Des Moines to San Francisco. Data last updated May 10, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Francisco. Data last updated May 10, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Mon 6/16:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/9![Frontier logo]()
$254
This Frontier deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Wed 6/36:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/5![Frontier logo]()
$230
This Expedia deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Mon 6/16:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/6![Frontier logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/299:36 pm
DSM
- SFO
1 stop13h 13m
Multiple Airlines
Tue 6/910:58 pm
SFO
- DSM
1 stop11h 57m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$280
This Frontier deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Wed 6/36:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/5![Frontier logo]()
$250
This Expedia deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- SFO
1 stop23h 31m
Frontier
Mon 6/86:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/8![Frontier logo]()
$270
This Frontier deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Wed 6/106:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/5![Frontier logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:16 pm
DSM
- SFO
2 stops31h 20m
Multiple Airlines
Tue 6/910:58 pm
SFO
- DSM
1 stop11h 57m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$257
This Frontier deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- SFO
1 stop23h 27m
Frontier
Tue 6/1612:38 pm
SFO
- DSM
1 stop22h 53m
Frontier
Deal found 5/7![Frontier logo]()
$232
This Gotogate deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Fri 7/176:00 am
SFO
- DSM
1 stop5h 34m
Frontier
Deal found 5/8![Frontier logo]()
$281
This Frontier deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/292:26 pm
DSM
- SFO
1 stop12h 01m
Frontier
Tue 7/712:33 pm
SFO
- DSM
1 stop23h 01m
Frontier
Deal found 5/6![Frontier logo]()
$251
One-way flights from Des Moines to San FranciscoSearch for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 10, 2026.
Search for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 10, 2026.
This Frontier deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/292:19 pm
DSM
- SFO
1 stop11h 59m
Frontier
Deal found 5/6![Frontier logo]()
$111
This Expedia deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Deal found 5/7![Frontier logo]()
$131
This Expedia deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:16 pm
DSM
- SFO
1 stop23h 27m
Frontier
Deal found 5/7![Frontier logo]()
$134
This Kiwi.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/299:56 pm
DSM
- SFO
1 stop14h 32m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$137
This Frontier deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/312:19 pm
DSM
- SFO
1 stop8h 35m
Frontier
Deal found 5/6![Frontier logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:01 pm
DSM
- SFO
1 stop14h 53m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/812:56 pm
DSM
- SFO
2 stops37h 31m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$168
This Kiwi.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/82:19 pm
DSM
- SFO
2 stops20h 24m
Frontier
Deal found 5/6![Frontier logo]()
$178
This Kiwi.com deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/118:36 pm
DSM
- SFO
1 stop14h 15m
Multiple Airlines
Deal found 5/8![Multiple Airlines logo]()
$179
Find flight deals from Des Moines to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $210 (Frontier) |
One-way from | $111 (Frontier) |
Popular in | March |
Cheapest in | February |
Average price | $496 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 10, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Tue 6/9
7:00 pm-10:25 pm
1 stop5h 25m
San Francisco
Tue 6/16
10:25 am-9:40 pm
2 stops9h 15m
$400
Quickest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sat 6/6
6:55 pm-12:35 am
2 stops7h 40m
San Francisco
Mon 6/8
5:10 am-12:50 pm
1 stop5h 40m
$404
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 6/24
3:45 pm-11:25 pm
2 stops9h 40m
San Francisco
Wed 7/1
5:50 am-6:20 pm
2 stops10h 30m
$405
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Tue 7/28
2:45 pm-8:57 pm
1 stop8h 12m
San Francisco
Sun 8/2
12:12 am-10:18 am
1 stop8h 06m
$431
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Tue 6/9
7:00 pm-10:25 pm
1 stop5h 25m
San Francisco
Fri 6/12
11:40 pm-11:35 am
1 stop9h 55m
$436
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 7/2
10:54 am-5:15 pm
1 stop8h 21m
San Francisco
Sun 7/5
6:00 am-2:05 pm
1 stop6h 05m
$467
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 7/16
6:10 am-11:20 am
2 stops7h 10m
San Francisco
Sun 7/19
5:30 am-3:35 pm
1 stop8h 05m
$472
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 7/16
6:10 am-1:00 pm
2 stops8h 50m
San Francisco
Mon 7/20
9:45 am-10:20 pm
2 stops10h 35m
$477
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sat 6/20
6:10 am-1:10 pm
2 stops9h 00m
San Francisco
Sat 6/27
7:05 am-9:55 pm
2 stops12h 50m
$483
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Mon 6/8
6:10 am-12:00 pm
2 stops7h 50m
San Francisco
Fri 8/7
8:30 am-9:15 pm
2 stops10h 45m
$499
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Francisco in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Des Moines with our price prediction graph.
DSM-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Francisco
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How far ahead should I book a flight from Des Moines to San Francisco?
Booking 57 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Des Moines to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Des Moines to San Francisco (average of $365). Flying from Des Moines to San Francisco in March is currently the most expensive (average of $496). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Francisco?
How often are flights from Des Moines to San Francisco delayed?
About 0% of weekly flights between Des Moines and San Francisco have experienced delays in the past year, with the average delay time being 0 minutes.
What is the most punctual flight time for Des Moines to San Francisco flights?
Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What’s the top layover airport for flights from Des Moines to San Francisco?
Share of 1-stop round-trip flights from Des Moines to San Francisco chosen by Cheapflights users in the past 12 months, using the same layover each way.
Dallas (DFW) – chosen by Cheapflights users on 50% of 1-stop itineraries from Des Moines to San Francisco on Cheapflights.
What’s the cheapest layover airport for flights from Des Moines to San Francisco?
Average round-trip fare for 1-stop flights from Des Moines to San Francisco, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $381.
What’s the fastest layover option from Des Moines to San Francisco?
Shortest average travel time for 1-stop one-way flights from Des Moines to San Francisco, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 5h 40m.
Which airport typically offers the quickest layover for flights from Des Moines to San Francisco?
Average layover duration for 1-stop one-way flights from Des Moines to San Francisco, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 05m.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated May 10, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
8.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Overall
8.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Overall
8.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Overall
8.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Overall
8.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Overall
8.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Fairfield
Rancho Cordova
San Bruno
Watsonville
San Ramon
Vacaville
Roseville
San Carlos
Redwood City
Sunnyvale
Turlock
Vallejo
San Lorenzo
Davis
Emeryville
Manteca
Elk Grove
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Des Moines and San Francisco flights
Browse other Des Moines and San Francisco flight options. Last updated on May 10, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on May 10, 2026.
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Other flights to San Francisco
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Top 5 airlines flying from Des Moines to San Francisco
Discover the top 5 airlines that operate flights from Des Moines to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$120 | Average$260 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$263 | Average$372 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$321 | Average$515 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$336 | Average$476 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$350 | Average$428 | FlexibilityNo cancel fee | On-time71% |