What is the most punctual flight time for Des Moines to San Francisco flights?

Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.

How often are flights from Des Moines to San Francisco delayed?

About 0% of weekly flights between Des Moines and San Francisco have experienced delays in the past year, with the average delay time being 0 minutes.

What day of the week experiences the fewest flight delays on this route?

Tuesday tends to have the lowest number of delays on this route, whereas Wednesday has historically faced a higher average of delays compared to other days of the week.

How long is the flight from Des Moines to San Francisco?

Frontier and Delta can get you from Des Moines to San Francisco in just under 9h 03m. Your travel time can differ by up to 20h 52m. Airlines will cover a distance of 1545 mi. This flight may include one or multiple stops.

What are the cheapest airlines flying from Des Moines to San Francisco round-trip?

Our cheapest airline available from Des Moines to San Francisco is Frontier. Our recent data shows that you can find tickets from as low as $118 on this airline. Additional options worth looking into are Delta and American Airlines, starting at $265 and $336 round-trip. Frontier is currently priced 72% below the average price you’ll pay for this route.

What are the cheapest airlines to fly from Des Moines to San Francisco one-way?

The cheapest airline one-way is Southwest, with whom users have recently found tickets for as low as $123. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from Des Moines to San Francisco for a low price.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What are the most popular airlines that fly from Des Moines to San Francisco?

The most popular airlines flying from Des Moines to San Francisco are American Airlines, United Airlines and Southwest. Something to consider prior to booking your flight.

Most accurate provider : When it comes to deals on Des Moines-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to San Francisco that include hotel bookings?

Yes. In addition to deals on Des Moines to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to San Francisco.

Can I find deals for business class flights from Des Moines to San Francisco?

Yes. Cheapflights offers flight deals from Des Moines to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$123+ Flights from Des Moines to San Francisco

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Des Moines to San Francisco are usually found in August or September, booked 1 days in advance, depart on a Thursday or Wednesday and return on a Wednesday

Cheap flight deals from Des Moines to San Francisco

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$212 (Kiwi.com)
One-way from	$123 (Southwest)
Popular in	March
Cheapest in	August
Average price	$445

Provider with most accurate pricing for Des Moines-San Francisco flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-San Francisco flights.

Search Deals

From Des Moines to San Francisco

Search Deals

One-way flight from Des Moines to San Francisco

Search Deals

Highest demand for flights based on searches. 7% potential increase in price ($34 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in October 2025

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Find flight deals from Des Moines to San Francisco

Cheapest flights from Des Moines to San Francisco
Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on outubro 24, 2025.

sex 12/198:29 pmDSM - SFO

1 stop29h 55mFrontier

qui 1/16:00 amSFO - DSM

2 stops35h 44mFrontier

Deal found 10/24

$212

ter 12/232:35 pmDSM - SFO

1 stop11h 49mFrontier

qui 1/16:00 amSFO - DSM

2 stops35h 44mFrontier

Deal found 10/24

$219

sex 10/312:32 pmDSM - SFO

1 stop11h 42mFrontier

seg 11/36:34 amSFO - DSM

1 stop5h 13mFrontier

Deal found 10/22

$228

sex 10/312:32 pmDSM - SFO

1 stop11h 42mFrontier

dom 11/28:09 pmSFO - DSM

1 stop15h 38mFrontier

Deal found 10/22

$234

sex 12/198:29 pmDSM - SFO

1 stop29h 55mFrontier

sex 1/24:06 pmSFO - DSM

2 stops25h 38mFrontier

Deal found 10/24

$235

sex 12/198:29 pmDSM - SFO

1 stop29h 55mFrontier

seg 1/56:00 amSFO - DSM

2 stops11h 44mFrontier

Deal found 10/24

$236

sáb 12/65:21 amDSM - SFO

1 stop15h 53mAmerican Airlines

sáb 12/138:20 amSFO - DSM

1 stop13h 39mAmerican Airlines

Deal found 10/22

$241

ter 12/232:35 pmDSM - SFO

1 stop11h 49mFrontier

sex 1/24:06 pmSFO - DSM

2 stops25h 38mFrontier

Deal found 10/24

$245

ter 12/232:35 pmDSM - SFO

1 stop11h 49mFrontier

seg 1/56:00 amSFO - DSM

2 stops11h 44mFrontier

Deal found 10/24

$246

sex 12/198:29 pmDSM - SFO

2 stops37h 19mMultiple Airlines

qua 12/316:00 amSFO - DSM

1 stop6h 10mMultiple Airlines

Deal found 10/24

$260

sex 12/198:29 pmDSM - SFO

2 stops37h 19mFrontier

sáb 1/36:24 amSFO - DSM

1 stop11h 20mFrontier

Deal found 10/24

$261

Best flights from Des Moines to San Francisco
Discover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated outubro 24, 2025.

sex 12/198:29 pmDSM - SFO

1 stop29h 55mFrontier

sex 1/24:06 pmSFO - DSM

2 stops25h 38mFrontier

Deal found 10/24

$235

dom 12/218:30 amDSM - SFO

1 stop15h 16mMultiple Airlines

sex 1/24:06 pmSFO - DSM

2 stops25h 38mMultiple Airlines

Deal found 10/24

$285

sáb 12/611:01 amDSM - SFO

1 stop9h 03mDelta

sex 12/1212:30 amSFO - DSM

1 stop7h 51mDelta

Deal found 10/24

$287

ter 12/232:35 pmDSM - SFO

1 stop11h 49mMultiple Airlines

qua 12/316:00 amSFO - DSM

1 stop6h 10mMultiple Airlines

Deal found 10/24

$287

dom 12/218:30 amDSM - SFO

1 stop15h 16mMultiple Airlines

seg 1/56:00 amSFO - DSM

2 stops11h 44mMultiple Airlines

Deal found 10/24

$291

sex 12/198:29 pmDSM - SFO

1 stop29h 55mMultiple Airlines

ter 12/306:00 amSFO - DSM

1 stop7h 31mMultiple Airlines

Deal found 10/24

$301

seg 3/25:15 pmDSM - SFO

1 stop8h 36mDelta

qua 3/46:00 amSFO - DSM

1 stop8h 56mDelta

Deal found 10/21

$367

Last-minute flights from Des Moines to San Francisco
Discover last-minute flight deals from Des Moines to San Francisco. Data last updated outubro 24, 2025 and is based on user searches.

seg 10/272:39 pmDSM - SFO

1 stop11h 35mFrontier

qui 10/3012:43 pmSFO - DSM

1 stop23h 04mFrontier

Deal found 10/22

$322

sex 10/312:32 pmDSM - SFO

1 stop11h 42mFrontier

seg 11/36:34 amSFO - DSM

1 stop5h 13mFrontier

Deal found 10/22

$228

sex 10/312:32 pmDSM - SFO

1 stop11h 42mFrontier

dom 11/28:09 pmSFO - DSM

1 stop15h 38mFrontier

Deal found 10/22

$234

qui 11/62:41 pmDSM - SFO

1 stop11h 33mFrontier

seg 11/106:34 amSFO - DSM

1 stop5h 13mFrontier

Deal found 10/23

$282

sex 11/72:32 pmDSM - SFO

1 stop11h 42mFrontier

ter 11/118:55 pmSFO - DSM

2 stops39h 01mFrontier

Deal found 10/22

$289

sáb 11/810:00 amDSM - SFO

2 stops15h 47mMultiple Airlines

ter 11/118:55 pmSFO - DSM

1 stop17h 13mMultiple Airlines

Deal found 10/22

$317

seg 11/102:32 pmDSM - SFO

2 stops28h 11mMultiple Airlines

sex 11/145:45 amSFO - DSM

1 stop14h 55mMultiple Airlines

Deal found 10/22

$308

seg 11/173:45 pmDSM - SFO

2 stops30h 25mMultiple Airlines

qui 11/206:00 amSFO - DSM

1 stop7h 27mMultiple Airlines

Deal found 10/23

$320

seg 11/246:17 amDSM - SFO

1 stop9h 58mDelta

qui 11/275:45 amSFO - DSM

1 stop6h 23mDelta

Deal found 10/23

$295

seg 11/243:48 pmDSM - SFO

1 stop7h 15mMultiple Airlines

qui 11/278:53 pmSFO - DSM

2 stops20h 08mMultiple Airlines

Deal found 10/23

$302

One-way flights from Des Moines to San Francisco
Search for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated outubro 24, 2025.

qua 1/78:35 amDSM - SFO

1 stop8h 20mSouthwest

Deal found 10/23

$123

sáb 12/62:08 pmDSM - SFO

1 stop10h 17mAmerican Airlines

Deal found 10/22

$144

qua 1/76:14 pmDSM - SFO

3 stops39h 59mMultiple Airlines

Deal found 10/23

$180

sáb 12/611:01 amDSM - SFO

2 stops13h 30mDelta

Deal found 10/22

$186

qui 12/255:30 amDSM - SFO

1 stop6h 13mUnited Airlines

Deal found 10/22

$203

dom 12/711:29 amDSM - SFO

1 stop7h 51mAmerican Airlines

Deal found 10/23

$204

sáb 11/295:45 amDSM - SFO

1 stop5h 50mUnited Airlines

Deal found 10/23

$224

qui 12/2512:05 pmDSM - SFO

2 stops10h 05mSouthwest

Deal found 10/22

$265

seg 12/2911:40 amDSM - SFO

2 stops11h 35mSouthwest

Deal found 10/22

$279

dom 12/75:15 pmDSM - SFO

2 stops16h 13mUnited Airlines

Deal found 10/23

$304

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

sex 12/19

8:29 pm-12:24 am

1 stop29h 55m

San Francisco

sex 1/2

4:06 pm-7:44 pm

2 stops25h 38m

$235

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

dom 12/21

8:30 am-9:46 pm

1 stop15h 16m

San Francisco

sex 1/2

4:06 pm-7:44 pm

2 stops25h 38m

$285

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

sáb 12/6

11:01 am-6:04 pm

1 stop9h 03m

San Francisco

sex 12/12

12:30 am-10:21 am

1 stop7h 51m

$287

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

ter 12/23

2:35 pm-12:24 am

1 stop11h 49m

San Francisco

qua 12/31

6:00 am-2:10 pm

1 stop6h 10m

$287

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

dom 12/21

8:30 am-9:46 pm

1 stop15h 16m

San Francisco

seg 1/5

6:00 am-7:44 pm

2 stops11h 44m

$291

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

sex 12/19

8:29 pm-12:24 am

1 stop29h 55m

San Francisco

ter 12/30

6:00 am-3:31 pm

1 stop7h 31m

$301

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

seg 3/2

5:15 pm-11:51 pm

1 stop8h 36m

San Francisco

qua 3/4

6:00 am-4:56 pm

1 stop8h 56m

$367

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

qua 1/7

8:35 am-2:55 pm

1 stop8h 20m

$123

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

sáb 12/6

2:08 pm-10:25 pm

1 stop10h 17m

$144

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

qua 1/7

6:14 pm-8:13 am

3 stops39h 59m

$180

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/23

Showing 1-10 of 18 results

Compare providers for flights from Des Moines to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Francisco in October.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to San Francisco

Prices

Delays

What is the cheapest month to book a flight from Des Moines to San Francisco?

Currently, December is the cheapest month in which you can book a flight from Des Moines to San Francisco (average of $144). Flying from Des Moines to San Francisco in May is currently the most expensive (average of $304). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SFO?

A simple way to save on the total cost of your ticket is to fly from Des Moines to San Francisco in the evening. If you’re flexible enough to do this you can expect to save up to 74% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Des Moines to San Francisco?

Travelers seeking maximum savings on their Des Moines to San Francisco flight should consider departing on Tuesday evenings when fares are most often at their lowest. Wednesday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing San Francisco

Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,236 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Southwest

8.0

Very good

4,236 reviews

Southwest

8.0

Very good

4,236 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Delta

7.9

Good

7,982 reviews

Southwest

8.0

Very good

4,236 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

United Airlines

7.4

Good

8,995 reviews

Southwest

8.0

Very good

4,236 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

American Airlines

7.2

Good

11,033 reviews

Southwest

8.0

Very good

4,236 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Frontier

5.8

Fair

3,128 reviews

Southwest

8.0

Very good

4,236 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Related info for your journey

How long is the flight from Des Moines to San Francisco?
Frontier and Delta can get you from Des Moines to San Francisco in just under 9h 03m. Your travel time can differ by up to 20h 52m. Airlines will cover a distance of 1545 mi. This flight may include one or multiple stops.
What are the cheapest airlines flying from Des Moines to San Francisco round-trip?
Our cheapest airline available from Des Moines to San Francisco is Frontier. Our recent data shows that you can find tickets from as low as $118 on this airline. Additional options worth looking into are Delta and American Airlines, starting at $265 and $336 round-trip. Frontier is currently priced 72% below the average price you’ll pay for this route.
What are the cheapest airlines to fly from Des Moines to San Francisco one-way?
The cheapest airline one-way is Southwest, with whom users have recently found tickets for as low as $123. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from Des Moines to San Francisco for a low price.
Can I find deals for flights from Des Moines to San Francisco that include hotel bookings?
Yes. In addition to deals on Des Moines to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to San Francisco.
Can I find deals for business class flights from Des Moines to San Francisco?
Yes. Cheapflights offers flight deals from Des Moines to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to San Francisco?
Currently, December is the cheapest month in which you can book a flight from Des Moines to San Francisco (average of $144). Flying from Des Moines to San Francisco in May is currently the most expensive (average of $304). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

Santa Cruz

Livermore

South San Francisco

Turlock

Antioch

Watsonville

Santa Clara

Manteca

Sunnyvale

Vacaville

Vallejo

Hollister

Foster City

Union City

Fairfield

Burlingame

Redwood City

Lodi

San Mateo

Browse thousands of different options on Cheapflights for your next trip

Top 5 airlines flying from Des Moines to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$118	Average$247	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$265	Average$419	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$336	Average$417	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$344	Average$425	FlexibilityNo cancel fee	On-time63%
United Airlines	Cheapest$353	Average$511	FlexibilityNo cancel fee	On-time69%

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$123+ Cheap flights from Des Moines to San Francisco (DSM - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/7. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Des Moines to San Francisco are usually found in August or September, booked 1 days in advance, depart on a Thursday or Wednesday and return on a Wednesday

Cheap flight deals from Des Moines to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to San Francisco

Cheapest flights from Des Moines to San FranciscoExplore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on outubro 24, 2025.

Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on outubro 24, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.

Compare providers for flights from Des Moines to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Francisco in October.

Best time to book a flight from Des Moines to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to San Francisco

What is the cheapest month to book a flight from Des Moines to San Francisco?

What is the cheapest time of day to fly from DSM to SFO?

What is the cheapest day to fly from Des Moines to San Francisco?

How often are flights from Des Moines to San Francisco delayed?

What is the most punctual flight time for Des Moines to San Francisco flights?

What day of the week experiences the fewest flight delays on this route?

Reviews of airlines servicing San Francisco

Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Des Moines to San Francisco?

What are the cheapest airlines flying from Des Moines to San Francisco round-trip?

What are the cheapest airlines to fly from Des Moines to San Francisco one-way?

Can I find deals for flights from Des Moines to San Francisco that include hotel bookings?

How can I find direct flights from Des Moines to San Francisco?

Can I find deals for business class flights from Des Moines to San Francisco?

What is the cheapest month to book a flight from Des Moines to San Francisco?

Traveling to a place near San Francisco?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Des Moines to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top 5 airlines flying from Des Moines to San Francisco

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Cheapest flights from Des Moines to San Francisco
Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on outubro 24, 2025.