$111+ Cheap flights from Des Moines to San Francisco (DSM - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Apr 22 — Apr 291
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to San Francisco
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Best
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Cheapest flights from Des Moines to San FranciscoExplore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 23, 2026.
Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 23, 2026.
This Expedia deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:14 pm
DSM
- SFO
1 stop6h 14m
Frontier
Mon 4/136:00 am
SFO
- DSM
1 stop11h 14m
Frontier
Deal found 3/20![Frontier logo]()
$180
This Expedia deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:14 pm
DSM
- SFO
1 stop25h 51m
Frontier
Fri 4/106:00 am
SFO
- DSM
1 stop11h 14m
Frontier
Deal found 3/22![Frontier logo]()
$200
This Frontier deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Wed 5/136:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 3/22![Frontier logo]()
$209
This Frontier deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
- SFO
1 stop6h 04m
Frontier
Mon 5/116:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 3/20![Frontier logo]()
$250
This Expedia deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/38:14 pm
DSM
- SFO
1 stop6h 09m
Frontier
Mon 4/66:00 am
SFO
- DSM
1 stop11h 14m
Frontier
Deal found 3/20![Frontier logo]()
$255
This CheapOair deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/172:16 pm
DSM
- SFO
1 stop12h 06m
Frontier
Tue 6/2312:33 pm
SFO
- DSM
1 stop22h 58m
Frontier
Deal found 3/22![Frontier logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/153:32 pm
DSM
- SFO
1 stop18h 58m
Multiple Airlines
Tue 5/1910:40 pm
SFO
- DSM
1 stop12h 19m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$269
Best flights from Des Moines to San FranciscoDiscover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 23, 2026.
Discover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 23, 2026.
This United Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:35 pm
DSM
- SFO
1 stop5h 55m
United Airlines
Wed 5/275:00 am
SFO
- DSM
1 stop5h 36m
United Airlines
Deal found 3/18![United Airlines logo]()
$391
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:35 am
DSM
- SFO
1 stop9h 00m
Southwest
Sat 5/910:00 am
SFO
- DSM
1 stop6h 00m
Southwest
Deal found 3/18![Southwest logo]()
$399
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:35 pm
DSM
- SFO
1 stop8h 10m
Delta
Fri 7/3112:40 am
SFO
- DSM
1 stop7h 35m
Delta
Deal found 3/18![Delta logo]()
$467
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:10 pm
DSM
- SFO
1 stop5h 55m
Southwest
Thu 4/236:20 am
SFO
- DSM
2 stops10h 15m
Southwest
Deal found 3/18![Southwest logo]()
$414
This Southwest deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:50 am
DSM
- SFO
2 stops8h 35m
Southwest
Mon 4/2711:10 am
SFO
- DSM
2 stops9h 55m
Southwest
Deal found 3/19![Southwest logo]()
$419
This Southwest deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/612:00 pm
DSM
- SFO
2 stops9h 55m
Southwest
Wed 5/1310:05 am
SFO
- DSM
2 stops9h 10m
Southwest
Deal found 3/21![Southwest logo]()
$427
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/175:25 am
DSM
- SFO
1 stop9h 20m
Southwest
Mon 4/205:25 am
SFO
- DSM
1 stop5h 45m
Southwest
Deal found 3/18![Southwest logo]()
$433
This Southwest deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/42:25 pm
DSM
- SFO
1 stop7h 05m
Southwest
Tue 9/81:25 pm
SFO
- DSM
1 stop5h 35m
Southwest
Deal found 3/21![Southwest logo]()
$467
This Southwest deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:10 pm
DSM
- SFO
1 stop5h 55m
Southwest
Sun 5/2410:10 am
SFO
- DSM
2 stops9h 05m
Southwest
Deal found 3/19![Southwest logo]()
$472
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:10 am
DSM
- SFO
2 stops9h 00m
Southwest
Sun 6/145:30 am
SFO
- DSM
1 stop8h 05m
Southwest
Deal found 3/18![Southwest logo]()
$482
Last-minute flights from Des Moines to San FranciscoDiscover last-minute flight deals from Des Moines to San Francisco. Data last updated March 23, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Francisco. Data last updated March 23, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/258:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Sat 3/286:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Deal found 3/22![Frontier logo]()
$325
This Expedia deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/38:14 pm
DSM
- SFO
1 stop6h 09m
Frontier
Mon 4/66:00 am
SFO
- DSM
1 stop11h 14m
Frontier
Deal found 3/20![Frontier logo]()
$255
This CheapOair deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/38:14 pm
DSM
- SFO
1 stop6h 09m
Frontier
Sun 4/59:00 pm
SFO
- DSM
1 stop20h 14m
Frontier
Deal found 3/22![Frontier logo]()
$291
This Expedia deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:14 pm
DSM
- SFO
1 stop6h 14m
Frontier
Mon 4/136:00 am
SFO
- DSM
1 stop11h 14m
Frontier
Deal found 3/20![Frontier logo]()
$180
This Expedia deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:14 pm
DSM
- SFO
1 stop25h 51m
Frontier
Fri 4/106:00 am
SFO
- DSM
1 stop11h 14m
Frontier
Deal found 3/22![Frontier logo]()
$200
This CheapOair deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:14 pm
DSM
- SFO
1 stop25h 51m
Frontier
Thu 4/99:05 pm
SFO
- DSM
1 stop20h 09m
Frontier
Deal found 3/21![Frontier logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/69:45 pm
DSM
- SFO
2 stops24h 20m
Multiple Airlines
Thu 4/910:57 pm
SFO
- DSM
1 stop20h 24m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$378
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/69:45 pm
DSM
- SFO
2 stops25h 23m
Multiple Airlines
Fri 4/1011:20 am
SFO
- DSM
1 stop8h 01m
Multiple Airlines
Deal found 3/22![Multiple Airlines logo]()
$388
This United Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/88:04 am
DSM
- SFO
1 stop7h 23m
United Airlines
Sat 4/118:20 am
SFO
- DSM
1 stop5h 55m
United Airlines
Deal found 3/18![United Airlines logo]()
$391
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:30 pm
DSM
- SFO
1 stop5h 40m
Southwest
Sat 4/117:45 am
SFO
- DSM
2 stops8h 15m
Southwest
Deal found 3/18![Southwest logo]()
$396
This Expedia deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:04 pm
DSM
- SFO
1 stop12h 23m
Multiple Airlines
Sat 5/28:45 am
SFO
- DSM
2 stops13h 04m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$395
One-way flights from Des Moines to San FranciscoSearch for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated March 23, 2026.
Search for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated March 23, 2026.
This Frontier deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Deal found 3/22![Frontier logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:15 pm
DSM
- SFO
1 stop16h 26m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$118
This Frontier deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Deal found 3/22![Frontier logo]()
$131
This Priceline deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/38:14 pm
DSM
- SFO
1 stop6h 09m
Frontier
Deal found 3/18![Frontier logo]()
$135
This Frontier deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Deal found 3/19![Frontier logo]()
$151
This Frontier deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/288:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Deal found 3/19![Frontier logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3110:26 pm
DSM
- SFO
1 stop12h 23m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$164
This American Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/53:20 pm
DSM
- SFO
1 stop8h 44m
American Airlines
Deal found 3/18![American Airlines logo]()
$191
This United Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:32 pm
DSM
- SFO
1 stop6h 14m
United Airlines
Deal found 3/19![United Airlines logo]()
$192
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/512:00 pm
DSM
- SFO
2 stops8h 30m
Southwest
Deal found 3/18![Southwest logo]()
$197
Find flight deals from Des Moines to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $180 (Expedia) |
One-way from | $111 (Frontier) |
Popular in | March |
Cheapest in | February |
Average price | $516 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sat 5/23
1:35 pm-5:30 pm
1 stop5h 55m
San Francisco
Wed 5/27
5:00 am-12:36 pm
1 stop5h 36m
$391
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sat 5/2
5:35 am-12:35 pm
1 stop9h 00m
San Francisco
Sat 5/9
10:00 am-6:00 pm
1 stop6h 00m
$399
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 4/16
7:10 pm-11:05 pm
1 stop5h 55m
San Francisco
Thu 4/23
6:20 am-6:35 pm
2 stops10h 15m
$414
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 4/23
6:50 am-1:25 pm
2 stops8h 35m
San Francisco
Mon 4/27
11:10 am-11:05 pm
2 stops9h 55m
$419
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 5/6
12:00 pm-7:55 pm
2 stops9h 55m
San Francisco
Wed 5/13
10:05 am-9:15 pm
2 stops9h 10m
$427
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Fri 4/17
5:25 am-12:45 pm
1 stop9h 20m
San Francisco
Mon 4/20
5:25 am-1:10 pm
1 stop5h 45m
$433
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Tue 7/28
5:35 pm-11:45 pm
1 stop8h 10m
San Francisco
Fri 7/31
12:40 am-10:15 am
1 stop7h 35m
$467
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Fri 9/4
2:25 pm-7:30 pm
1 stop7h 05m
San Francisco
Tue 9/8
1:25 pm-9:00 pm
1 stop5h 35m
$467
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Fri 5/22
7:10 pm-11:05 pm
1 stop5h 55m
San Francisco
Sun 5/24
10:10 am-9:15 pm
2 stops9h 05m
$472
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sat 6/6
6:10 am-1:10 pm
2 stops9h 00m
San Francisco
Sun 6/14
5:30 am-3:35 pm
1 stop8h 05m
$482
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Francisco in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Des Moines with our price prediction graph.
DSM-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Francisco
Prices
Delays
More
How far ahead should I book a flight from Des Moines to San Francisco?
Use this chart to determine the optimal time to book a round-trip flight from Des Moines to San Francisco. Price data was last updated on March 13, 2026.
Booking 44 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Des Moines to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Des Moines to San Francisco (average of $150). Flying from Des Moines to San Francisco in May is currently the most expensive (average of $331). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How often are flights from Des Moines to San Francisco delayed?
About 0% of weekly flights between Des Moines and San Francisco have experienced delays in the past year, with the average delay time being 0 minutes.
What is the most punctual flight time for Des Moines to San Francisco flights?
Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What’s the top layover airport for flights from Des Moines to San Francisco?
Share of 1-stop round-trip flights from Des Moines to San Francisco chosen by Cheapflights users in the past 12 months, using the same layover each way.
Dallas (DFW) – chosen by Cheapflights users on 50% of 1-stop itineraries from Des Moines to San Francisco on Cheapflights.
What’s the cheapest layover airport for flights from Des Moines to San Francisco?
Average round-trip fare for 1-stop flights from Des Moines to San Francisco, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $381.
What’s the fastest layover option from Des Moines to San Francisco?
Shortest average travel time for 1-stop one-way flights from Des Moines to San Francisco, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 5h 40m.
Which airport typically offers the quickest layover for flights from Des Moines to San Francisco?
Average layover duration for 1-stop one-way flights from Des Moines to San Francisco, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 05m.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated March 23, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
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Des Moines and San Francisco flights
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Top 5 airlines flying from Des Moines to San Francisco
Discover the top 5 airlines that operate flights from Des Moines to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$158 | Average$258 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$243 | Average$365 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$334 | Average$412 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$336 | Average$447 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$342 | Average$508 | FlexibilityNo cancel fee | On-time69% |