$122+ Cheap flights from Des Moines to San Francisco (DSM - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/17. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Nov 25 — Dec 21
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to San Francisco
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Cheapest flights from Des Moines to San FranciscoExplore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/168:04 pm -
1 stop14h 15m
Thu 12/310:35 am -
1 stop9h 51m
Deal found 10/25![Multiple Airlines logo]()
$188
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1310:25 pm -
1 stop21h 54m
Mon 11/166:02 am -
1 stop11h 33m
Deal found 10/21![Multiple Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/149:18 pm -
1 stop14h 16m
Thu 12/245:20 pm -
2 stops20h 45m
Deal found 10/23![Multiple Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/149:18 pm -
1 stop14h 16m
Tue 12/155:00 pm -
2 stops17h 55m
Deal found 10/21![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:04 pm -
1 stop14h 15m
Thu 11/122:21 pm -
1 stop29h 14m
Deal found 10/22![Multiple Airlines logo]()
$253
Best flights from Des Moines to San FranciscoDiscover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
Discover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/114:25 pm -
1 stop10h 00m
Mon 12/146:10 am -
1 stop6h 05m
Deal found 10/21![Southwest logo]()
$303
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/92:58 pm -
1 stop10h 57m
Fri 12/116:00 am -
1 stop8h 11m
Deal found 10/22![Delta logo]()
$352
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/129:50 am -
1 stop8h 30m
Mon 11/166:16 am -
1 stop7h 51m
Deal found 10/21![United Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/27:38 pm -
1 stop6h 59m
Tue 1/57:00 am -
1 stop11h 45m
Deal found 10/25![American Airlines logo]()
$477
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/147:00 am -
1 stop6h 10m
Tue 12/1510:15 am -
1 stop5h 35m
Deal found 10/21![Southwest logo]()
$303
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/77:00 am -
1 stop6h 10m
Fri 12/116:00 am -
1 stop5h 10m
Deal found 10/23![Southwest logo]()
$303
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/146:41 am -
1 stop6h 26m
Mon 12/1411:59 pm -
1 stop8h 50m
Deal found 10/22![Delta logo]()
$417
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:53 pm -
2 stops16h 11m
Sat 12/2610:55 pm -
1 stop9h 00m
Deal found 10/24![Delta logo]()
$480
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/157:15 pm -
1 stop6h 10m
Tue 11/1710:25 am -
2 stops8h 25m
Deal found 10/25![Southwest logo]()
$441
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:55 am -
1 stop5h 57m
Sat 11/146:00 am -
1 stop6h 08m
Deal found 10/23![Delta logo]()
$487
Last-minute flights from Des Moines to San FranciscoDiscover last-minute flight deals from Des Moines to San Francisco. Data last updated October 26, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Francisco. Data last updated October 26, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/610:25 pm -
1 stop11h 54m
Mon 11/96:02 am -
1 stop11h 33m
Deal found 10/23![Multiple Airlines logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:04 pm -
1 stop14h 15m
Thu 11/122:21 pm -
1 stop29h 14m
Deal found 10/22![Multiple Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:30 pm -
1 stop5h 50m
Tue 11/109:14 am -
1 stop26h 41m
Deal found 10/22![Multiple Airlines logo]()
$267
This Frontier deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:30 pm -
1 stop5h 50m
Fri 11/1312:20 pm -
1 stop5h 15m
Deal found 10/22![Frontier logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/112:45 pm -
1 stop19h 34m
Thu 11/1212:20 pm -
1 stop29h 15m
Deal found 10/22![Multiple Airlines logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1310:25 pm -
1 stop21h 54m
Mon 11/166:02 am -
1 stop11h 33m
Deal found 10/21![Multiple Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/168:04 pm -
1 stop14h 15m
Thu 12/310:35 am -
1 stop9h 51m
Deal found 10/25![Multiple Airlines logo]()
$188
One-way flights from Des Moines to San FranciscoSearch for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 26, 2026.
Search for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/178:26 pm -
2 stops44h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Frontier logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/309:39 pm -
1 stop14h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Multiple Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/119:18 pm -
1 stop16h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/24![Multiple Airlines logo]()
$135
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:30 pm -
1 stop5h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Southwest logo]()
$152
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/157:49 pm -
1 stop15h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![American Airlines logo]()
$163
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:40 am -
2 stops8h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Southwest logo]()
$165
Find flight deals from Des Moines to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $188 (Kiwi.com) |
One-way from | $122 (Kiwi.com) |
Popular in | June |
Cheapest in | February |
Average price | $470 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Thu 12/17
8:26 pm-3:11 pm
2 stops44h 45m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$122
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Fri 12/11
9:18 pm-11:26 am
1 stop16h 08m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$135
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Mon 11/30
9:39 pm-9:43 pm
2 stops26h 04m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$148
Quickest round-trip
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Wed 11/18
6:30 pm-10:15 pm
1 stop5h 45m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$152
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Tue 11/17
6:30 pm-10:15 pm
1 stop5h 45m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$152
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Thu 12/17
6:40 am-1:05 pm
2 stops8h 25m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$165
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Fri 12/11
4:25 pm-12:25 am
1 stop10h 00m
San Francisco
Mon 12/14
6:10 am-2:15 pm
1 stop6h 05m
$303
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Mon 12/14
7:00 am-11:10 am
1 stop6h 10m
San Francisco
Tue 12/15
10:15 am-5:50 pm
1 stop5h 35m
$303
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Mon 12/7
7:00 am-11:10 am
1 stop6h 10m
San Francisco
Fri 12/11
6:00 am-1:10 pm
1 stop5h 10m
$303
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Wed 12/9
2:58 pm-11:55 pm
1 stop10h 57m
San Francisco
Fri 12/11
6:00 am-4:11 pm
1 stop8h 11m
$352
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Francisco in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Des Moines with our price prediction graph.
DSM-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Francisco
Prices
More
How far ahead should I book a flight from Des Moines to San Francisco?
Booking 26 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Des Moines to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Des Moines to San Francisco (average of $367). Flying from Des Moines to San Francisco in June is currently the most expensive (average of $562). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Francisco?
Airfare is below average for this route at the moment.
Des Moines to San Francisco flights typically cost between $415 and $666 in November.The cheapest round-trip price found within the last 5 days was $188 on Multiple Airlines (Nov 16-Dec 3).
What’s the top layover airport for flights from Des Moines to San Francisco?
Share of 1-stop round-trip flights from Des Moines to San Francisco chosen by Cheapflights users in the past 12 months, using the same layover each way.
Denver (DEN) – chosen by Cheapflights users on 88% of 1-stop itineraries from Des Moines to San Francisco on Cheapflights.
What’s the cheapest layover airport for flights from Des Moines to San Francisco?
Average round-trip fare for 1-stop flights from Des Moines to San Francisco, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $381.
What’s the fastest layover option from Des Moines to San Francisco?
Shortest average travel time for 1-stop one-way flights from Des Moines to San Francisco, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 5h 45m.
Which airport typically offers the quickest layover for flights from Des Moines to San Francisco?
Average layover duration for 1-stop one-way flights from Des Moines to San Francisco, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 06m.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated October 26, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.4
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
7.9
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.4
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
7.9
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.4
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
7.9
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.4
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
7.9
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.4
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
7.9
Boarding
8.1
Comfort
8.0
Crew
8.6
Entertainment
7.4
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Hayward
Emeryville
Newark
Burlingame
Rancho Cordova
Vallejo
Cupertino
Fairfield
Redwood City
Manteca
San Bruno
San Carlos
San Ramon
Turlock
Davis
Morgan Hill
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Des Moines and San Francisco flights
Browse other Des Moines and San Francisco flight options. Last updated on October 26, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on October 26, 2026.
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Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 26, 2026.
Top 5 airlines flying from Des Moines to San Francisco
Discover the top 5 airlines that operate flights from Des Moines to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$120 | Average$315 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$253 | Average$479 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$302 | Average$371 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$330 | Average$480 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$371 | Average$508 | FlexibilityNo cancel fee | On-time63% |