$124+ Cheap flights from Des Moines to San Francisco (DSM - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Dec 12 — Dec 191
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to San Francisco
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Cheapest flights from Des Moines to San FranciscoExplore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2026.
Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/611:40 am -
1 stop27h 42m
Thu 12/106:30 pm -
1 stop23h 58m
Deal found 11/10![Multiple Airlines logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:18 pm -
1 stop18h 09m
Mon 12/149:16 pm -
2 stops37h 39m
Deal found 11/9![Multiple Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:35 pm -
1 stop15h 09m
Thu 12/106:30 am -
1 stop11h 12m
Deal found 11/9![Frontier logo]()
$321
This Frontier deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:39 pm -
1 stop6h 11m
Sun 12/136:30 am -
1 stop11h 12m
Deal found 11/10![Frontier logo]()
$346
This Expedia deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:35 pm -
1 stop24h 40m
Sun 12/610:34 am -
1 stop7h 16m
Deal found 11/11![Frontier logo]()
$347
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/309:39 pm -
2 stops48h 34m
Thu 12/179:46 pm -
1 stop20h 59m
Deal found 11/11![Multiple Airlines logo]()
$357
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:35 pm -
2 stops18h 40m
Wed 12/97:26 pm -
1 stop22h 16m
Deal found 11/9![Frontier logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/119:18 pm -
1 stop18h 09m
Sat 12/199:23 pm -
2 stops22h 00m
Deal found 11/10![Multiple Airlines logo]()
$368
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/119:18 pm -
1 stop18h 09m
Mon 12/216:00 pm -
1 stop14h 35m
Deal found 11/10![Multiple Airlines logo]()
$372
Best flights from Des Moines to San FranciscoDiscover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 12, 2026.
Discover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/309:39 pm -
1 stop21h 56m
Thu 12/179:46 pm -
1 stop20h 59m
Deal found 11/11![Multiple Airlines logo]()
$381
This Southwest deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/133:00 pm -
1 stop9h 40m
Wed 1/206:40 am -
2 stops9h 05m
Deal found 11/7![Southwest logo]()
$398
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/126:45 am -
1 stop6h 25m
Tue 1/1910:31 pm -
1 stop9h 28m
Deal found 11/11![Delta logo]()
$403
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/129:00 am -
1 stop8h 15m
Fri 1/14:29 pm -
1 stop5h 30m
Deal found 11/11![United Airlines logo]()
$438
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/206:45 am -
1 stop8h 05m
Tue 1/2611:58 am -
2 stops21h 03m
Deal found 11/11![Delta logo]()
$413
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/812:05 pm -
2 stops8h 15m
Fri 1/89:25 am -
2 stops10h 10m
Deal found 11/9![Southwest logo]()
$428
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/1211:46 am -
1 stop9h 07m
Mon 1/1811:53 pm -
1 stop9h 08m
Deal found 11/11![Delta logo]()
$423
This Southwest deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/194:15 pm -
2 stops10h 10m
Mon 1/46:00 am -
1 stop5h 10m
Deal found 11/8![Southwest logo]()
$438
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2010:40 am -
1 stop10h 22m
Mon 1/2511:59 pm -
1 stop8h 13m
Deal found 11/11![Delta logo]()
$423
This Southwest deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/127:00 am -
2 stops9h 30m
Fri 1/16:10 am -
1 stop6h 05m
Deal found 11/11![Southwest logo]()
$443
Last-minute flights from Des Moines to San FranciscoDiscover last-minute flight deals from Des Moines to San Francisco. Data last updated November 12, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Francisco. Data last updated November 12, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/309:39 pm -
2 stops48h 34m
Thu 12/179:46 pm -
1 stop20h 59m
Deal found 11/11![Multiple Airlines logo]()
$357
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:35 pm -
1 stop15h 09m
Thu 12/106:30 am -
1 stop11h 12m
Deal found 11/9![Frontier logo]()
$321
This Expedia deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:35 pm -
1 stop24h 40m
Sun 12/610:34 am -
1 stop7h 16m
Deal found 11/11![Frontier logo]()
$347
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:35 pm -
2 stops18h 40m
Wed 12/97:26 pm -
1 stop22h 16m
Deal found 11/9![Frontier logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/611:40 am -
1 stop27h 42m
Thu 12/106:30 pm -
1 stop23h 58m
Deal found 11/10![Multiple Airlines logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:18 pm -
1 stop18h 09m
Mon 12/149:16 pm -
2 stops37h 39m
Deal found 11/9![Multiple Airlines logo]()
$318
This Frontier deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:39 pm -
1 stop6h 11m
Sun 12/136:30 am -
1 stop11h 12m
Deal found 11/10![Frontier logo]()
$346
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/119:18 pm -
1 stop18h 09m
Sat 12/199:23 pm -
2 stops22h 00m
Deal found 11/10![Multiple Airlines logo]()
$368
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/119:18 pm -
1 stop18h 09m
Mon 12/216:00 pm -
1 stop14h 35m
Deal found 11/10![Multiple Airlines logo]()
$372
One-way flights from Des Moines to San FranciscoSearch for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated November 12, 2026.
Search for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated November 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/149:18 pm -
2 stops25h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/83:40 pm -
2 stops23h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$132
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:18 pm -
1 stop14h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$135
This Frontier deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/248:26 pm -
1 stop6h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/10![Frontier logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/312:21 pm -
1 stop18h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Multiple Airlines logo]()
$167
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/238:13 pm -
1 stop13h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/10![Multiple Airlines logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/32:21 pm -
1 stop18h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/7![Multiple Airlines logo]()
$181
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:30 pm -
1 stop5h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Southwest logo]()
$197
Find flight deals from Des Moines to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $213 (Kiwi.com) |
One-way from | $124 (Kiwi.com) |
Popular in | November |
Cheapest in | February |
Average price | $683 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 12, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Thu 12/24
8:26 pm-12:35 am
1 stop6h 09m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$162
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Sat 12/19
7:38 pm-12:37 am
1 stop6h 59m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$197
Quickest round-trip
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Tue 12/8
6:30 pm-10:15 pm
1 stop5h 45m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$197
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Wed 12/9
2:58 pm-11:55 pm
1 stop10h 57m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$197
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Fri 1/1
4:55 pm-7:39 am
1 stop16h 44m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$205
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Wed 12/23
5:40 pm-12:30 am
2 stops8h 50m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$207
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Thu 12/31
2:21 pm-9:33 am
2 stops21h 12m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$222
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Thu 12/24
4:00 pm-11:58 pm
1 stop9h 58m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$222
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Wed 12/30
8:13 pm-9:26 pm
2 stops27h 13m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$225
Des MoinesSan Francisco
DSM Des Moines - SFO San Francisco
DSMSFO
Des Moines
Fri 1/1
7:00 am-12:50 pm
2 stops7h 50m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$227
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Francisco in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Des Moines with our price prediction graph.
DSM-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Francisco
Prices
More
How far ahead should I book a flight from Des Moines to San Francisco?
Booking 26 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Des Moines to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Des Moines to San Francisco (average of $367). Flying from Des Moines to San Francisco in November is currently the most expensive (average of $683). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Francisco?
Airfare is below average for this route at the moment.
Des Moines to San Francisco flights typically cost between $405 and $774 in February.The cheapest round-trip price found within the last 5 days was $213 on Multiple Airlines (Feb 8-Feb 18).
What’s the top layover airport for flights from Des Moines to San Francisco?
Share of 1-stop round-trip flights from Des Moines to San Francisco chosen by Cheapflights users in the past 12 months, using the same layover each way.
Denver (DEN) – chosen by Cheapflights users on 88% of 1-stop itineraries from Des Moines to San Francisco on Cheapflights.
What’s the cheapest layover airport for flights from Des Moines to San Francisco?
Average round-trip fare for 1-stop flights from Des Moines to San Francisco, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $381.
What’s the fastest layover option from Des Moines to San Francisco?
Shortest average travel time for 1-stop one-way flights from Des Moines to San Francisco, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 5h 45m.
Which airport typically offers the quickest layover for flights from Des Moines to San Francisco?
Average layover duration for 1-stop one-way flights from Des Moines to San Francisco, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 06m.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated November 12, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Comfort
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Comfort
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Comfort
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Comfort
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Comfort
8.0
Boarding
8.1
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Top 5 airlines flying from Des Moines to San Francisco
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$120 | Average$315 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$253 | Average$479 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$302 | Average$371 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$330 | Average$480 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$346 | Average$506 | FlexibilityNo cancel fee | On-time63% |