$135+ Cheap flights from Des Moines to San Francisco (DSM - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/30. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Jul 3 — Jul 101
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to San FranciscoExplore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on Juni 3, 2026.
Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on Juni 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 7/1310:01 pm
DSM
- SFO
1 stop14h 29m
Multiple Airlines
Di 7/219:00 pm
SFO
- DSM
1 stop13h 59m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 7/1310:01 pm
DSM
- SFO
1 stop14h 29m
Multiple Airlines
Mi 7/229:00 pm
SFO
- DSM
1 stop21h 43m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$264
This Frontier deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 8/52:19 pm
DSM
- SFO
1 stop11h 59m
Frontier
Mi 8/126:00 am
SFO
- DSM
1 stop5h 34m
Frontier
Deal found 6/2![Frontier logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 7/1710:01 pm
DSM
- SFO
1 stop12h 47m
Multiple Airlines
Di 7/219:00 pm
SFO
- DSM
1 stop13h 59m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 6/279:30 am
DSM
- SFO
1 stop7h 29m
Multiple Airlines
Di 6/3010:58 pm
SFO
- DSM
1 stop12h 01m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
So 9/279:56 pm
DSM
- SFO
2 stops25h 22m
Multiple Airlines
Do 10/19:00 pm
SFO
- DSM
1 stop11h 57m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 7/2710:01 pm
DSM
- SFO
1 stop14h 29m
Multiple Airlines
Di 7/289:00 pm
SFO
- DSM
1 stop13h 59m
Multiple Airlines
Deal found 5/31![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 7/169:33 pm
DSM
- SFO
1 stop13h 15m
Multiple Airlines
Di 7/219:00 pm
SFO
- DSM
1 stop13h 59m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 7/151:49 pm
DSM
- SFO
1 stop8h 03m
Multiple Airlines
Di 7/219:00 pm
SFO
- DSM
1 stop13h 59m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$288
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 9/26:55 am
DSM
- SFO
1 stop6h 07m
Delta
Mo 9/712:40 am
SFO
- DSM
1 stop7h 35m
Delta
Deal found 6/1![Delta logo]()
$291
This CheapOair deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 8/122:19 pm
DSM
- SFO
1 stop11h 59m
Frontier
So 8/169:39 pm
SFO
- DSM
1 stop13h 55m
Frontier
Deal found 6/2![Frontier logo]()
$292
Best flights from Des Moines to San FranciscoDiscover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated Juni 3, 2026.
Discover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated Juni 3, 2026.
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 9/102:25 pm
DSM
- SFO
2 stops8h 10m
Southwest
Mo 9/1411:15 am
SFO
- DSM
1 stop8h 00m
Southwest
Deal found 6/1![Southwest logo]()
$383
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 8/154:11 pm
DSM
- SFO
1 stop9h 43m
Delta
Fr 8/2110:10 pm
SFO
- DSM
1 stop10h 33m
Delta
Deal found 6/1![Delta logo]()
$397
This United Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 9/171:35 pm
DSM
- SFO
1 stop5h 59m
United Airlines
Sa 9/1912:35 am
SFO
- DSM
1 stop7h 51m
United Airlines
Deal found 5/30![United Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 9/126:20 am
DSM
- SFO
1 stop10h 09m
Delta
Fr 9/1810:10 pm
SFO
- DSM
1 stop10h 33m
Delta
Deal found 5/31![Delta logo]()
$397
This Southwest deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 8/1512:10 pm
DSM
- SFO
2 stops10h 25m
Southwest
Fr 8/2110:50 am
SFO
- DSM
2 stops8h 25m
Southwest
Deal found 6/1![Southwest logo]()
$435
This Southwest deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 8/1312:05 pm
DSM
- SFO
2 stops9h 00m
Southwest
Do 8/209:55 am
SFO
- DSM
2 stops9h 20m
Southwest
Deal found 5/30![Southwest logo]()
$435
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 9/264:10 pm
DSM
- SFO
1 stop9h 47m
Delta
Di 9/296:00 am
SFO
- DSM
2 stops13h 02m
Delta
Deal found 6/2![Delta logo]()
$443
This Southwest deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 7/155:20 am
DSM
- SFO
1 stop9h 15m
Southwest
So 7/196:25 am
SFO
- DSM
2 stops9h 05m
Southwest
Deal found 5/29![Southwest logo]()
$436
This Delta deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 7/114:47 pm
DSM
- SFO
2 stops17h 34m
Delta
Mo 7/1311:59 pm
SFO
- DSM
1 stop8h 46m
Delta
Deal found 5/30![Delta logo]()
$462
This Southwest deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 10/226:50 am
DSM
- SFO
1 stop5h 25m
Southwest
So 11/81:45 pm
SFO
- DSM
1 stop6h 15m
Southwest
Deal found 5/31![Southwest logo]()
$446
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 9/265:44 am
DSM
- SFO
1 stop8h 16m
Delta
So 9/276:10 am
SFO
- DSM
1 stop8h 31m
Delta
Deal found 6/2![Delta logo]()
$465
Last-minute flights from Des Moines to San FranciscoDiscover last-minute flight deals from Des Moines to San Francisco. Data last updated Juni 3, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Francisco. Data last updated Juni 3, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 6/82:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Mo 6/156:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/30![Frontier logo]()
$450
This Kiwi.com deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 6/89:56 pm
DSM
- SFO
1 stop14h 32m
Multiple Airlines
Do 6/1110:58 pm
SFO
- DSM
1 stop20h 08m
Multiple Airlines
Deal found 5/30![Multiple Airlines logo]()
$451
This CheapOair deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 6/102:16 pm
DSM
- SFO
1 stop23h 27m
Frontier
So 6/149:43 pm
SFO
- DSM
1 stop13h 48m
Frontier
Deal found 5/30![Frontier logo]()
$430
This Frontier deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 6/102:16 pm
DSM
- SFO
1 stop12h 11m
Frontier
Fr 6/126:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 6/1![Frontier logo]()
$504
This CheapOair deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 6/102:16 pm
DSM
- SFO
1 stop12h 11m
Frontier
Do 6/1812:38 pm
SFO
- DSM
1 stop22h 53m
Frontier
Deal found 6/2![Frontier logo]()
$511
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 6/101:45 pm
DSM
- SFO
1 stop21h 06m
Multiple Airlines
So 6/1410:58 pm
SFO
- DSM
1 stop20h 08m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$540
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 6/129:56 pm
DSM
- SFO
1 stop20h 40m
Multiple Airlines
So 6/1410:58 pm
SFO
- DSM
1 stop20h 08m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$529
This American Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 6/131:37 pm
DSM
- SFO
1 stop10h 30m
American Airlines
Mo 7/69:08 am
SFO
- DSM
1 stop7h 12m
American Airlines
Deal found 5/29![American Airlines logo]()
$527
This Southwest deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 6/135:10 am
DSM
- SFO
1 stop9h 35m
Southwest
Mo 7/612:00 pm
SFO
- DSM
2 stops8h 25m
Southwest
Deal found 5/29![Southwest logo]()
$532
One-way flights from Des Moines to San FranciscoSearch for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated Juni 3, 2026.
Search for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated Juni 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
So 8/309:50 pm
DSM
- SFO
2 stops25h 10m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 6/299:56 pm
DSM
- SFO
2 stops26h 17m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 8/310:01 pm
DSM
- SFO
2 stops25h 37m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 7/610:01 pm
DSM
- SFO
2 stops24h 44m
Multiple Airlines
Deal found 5/30![Multiple Airlines logo]()
$156
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 11/29:11 pm
DSM
- SFO
2 stops26h 07m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$158
This Frontier deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 6/242:16 pm
DSM
- SFO
1 stop12h 11m
Frontier
Deal found 6/1![Frontier logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 7/169:33 pm
DSM
- SFO
1 stop13h 15m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$168
This Frontier deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 6/192:16 pm
DSM
- SFO
1 stop8h 42m
Frontier
Deal found 6/2![Frontier logo]()
$174
Find flight deals from Des Moines to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated Juni 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $237 (Kiwi.com) |
One-way from | $135 (Kiwi.com) |
Popular in | March |
Cheapest in | February |
Average price | $484 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Juni 3, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Do 9/10
2:25 pm-8:35 pm
2 stops8h 10m
San Francisco
Mo 9/14
11:15 am-9:15 pm
1 stop8h 00m
$383
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sa 8/15
4:11 pm-11:54 pm
1 stop9h 43m
San Francisco
Fr 8/21
10:10 pm-10:43 am
1 stop10h 33m
$397
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sa 9/12
6:20 am-2:29 pm
1 stop10h 09m
San Francisco
Fr 9/18
10:10 pm-10:43 am
1 stop10h 33m
$397
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Do 9/17
1:35 pm-5:34 pm
1 stop5h 59m
San Francisco
Sa 9/19
12:35 am-10:26 am
1 stop7h 51m
$399
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sa 8/15
12:10 pm-8:35 pm
2 stops10h 25m
San Francisco
Fr 8/21
10:50 am-9:15 pm
2 stops8h 25m
$435
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Do 8/13
12:05 pm-7:05 pm
2 stops9h 00m
San Francisco
Do 8/20
9:55 am-9:15 pm
2 stops9h 20m
$435
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Mi 7/15
5:20 am-12:35 pm
1 stop9h 15m
San Francisco
So 7/19
6:25 am-5:30 pm
2 stops9h 05m
$436
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sa 9/26
4:10 pm-11:57 pm
1 stop9h 47m
San Francisco
Di 9/29
6:00 am-9:02 pm
2 stops13h 02m
$443
Quickest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Do 10/22
6:50 am-10:15 am
1 stop5h 25m
San Francisco
So 11/8
1:45 pm-10:00 pm
1 stop6h 15m
$446
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sa 7/11
4:47 pm-8:21 am
2 stops17h 34m
San Francisco
Mo 7/13
11:59 pm-10:45 am
1 stop8h 46m
$462
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Francisco in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Des Moines with our price prediction graph.
DSM-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Francisco
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How far ahead should I book a flight from Des Moines to San Francisco?
Booking 57 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Des Moines to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Des Moines to San Francisco (average of $365). Flying from Des Moines to San Francisco in March is currently the most expensive (average of $496). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Francisco?
How often are flights from Des Moines to San Francisco delayed?
About 0% of weekly flights between Des Moines and San Francisco have experienced delays in the past year, with the average delay time being 0 minutes.
What is the most punctual flight time for Des Moines to San Francisco flights?
Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What’s the top layover airport for flights from Des Moines to San Francisco?
Share of 1-stop round-trip flights from Des Moines to San Francisco chosen by Cheapflights users in the past 12 months, using the same layover each way.
Dallas (DFW) – chosen by Cheapflights users on 50% of 1-stop itineraries from Des Moines to San Francisco on Cheapflights.
What’s the cheapest layover airport for flights from Des Moines to San Francisco?
Average round-trip fare for 1-stop flights from Des Moines to San Francisco, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $381.
What’s the fastest layover option from Des Moines to San Francisco?
Shortest average travel time for 1-stop one-way flights from Des Moines to San Francisco, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 5h 40m.
Which airport typically offers the quickest layover for flights from Des Moines to San Francisco?
Average layover duration for 1-stop one-way flights from Des Moines to San Francisco, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 05m.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated Juni 3, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Fairfield
Rancho Cordova
Cupertino
San Bruno
Watsonville
San Ramon
Vacaville
Roseville
San Carlos
Redwood City
Daly City
Sunnyvale
Turlock
Vallejo
San Lorenzo
Davis
Emeryville
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Des Moines and San Francisco flights
Browse other Des Moines and San Francisco flight options. Last updated on Juni 3, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on Juni 3, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on Juni 3, 2026.
Top 5 airlines flying from Des Moines to San Francisco
Discover the top 5 airlines that operate flights from Des Moines to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Juni 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$158 | Average$270 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$263 | Average$372 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$321 | Average$502 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$336 | Average$486 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$346 | Average$444 | FlexibilityNo cancel fee | On-time71% |