$91+ Cheap flights from Des Moines to San Francisco (DSM - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Aug 17 — Aug 241
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to San Francisco
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Cheapest flights from Des Moines to San FranciscoExplore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 18, 2026.
Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:31 pm
DSM
- SFO
1 stop15h 15m
Multiple Airlines
Tue 9/2911:42 am
SFO
- DSM
1 stop24h 10m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$183
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm
DSM
- SFO
1 stop15h 15m
Multiple Airlines
Tue 10/611:42 am
SFO
- DSM
1 stop24h 10m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$187
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:06 pm
DSM
- SFO
1 stop14h 19m
Multiple Airlines
Wed 8/198:56 pm
SFO
- DSM
1 stop22h 04m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$196
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SFO
1 stop23h 50m
Multiple Airlines
Mon 8/2411:00 am
SFO
- DSM
1 stop6h 48m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1410:06 pm
DSM
- SFO
1 stop12h 37m
Multiple Airlines
Wed 8/198:56 pm
SFO
- DSM
1 stop22h 04m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:06 pm
DSM
- SFO
1 stop19h 14m
Multiple Airlines
Thu 8/2011:00 am
SFO
- DSM
1 stop8h 00m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$202
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SFO
1 stop14h 19m
Multiple Airlines
Thu 8/2011:00 am
SFO
- DSM
1 stop8h 00m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm
DSM
- SFO
1 stop15h 15m
Multiple Airlines
Wed 10/711:42 am
SFO
- DSM
1 stop29h 00m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$209
Best flights from Des Moines to San FranciscoDiscover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 18, 2026.
Discover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 18, 2026.
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/294:50 pm
DSM
- SFO
1 stop6h 35m
Southwest
Sat 9/56:25 am
SFO
- DSM
2 stops12h 20m
Southwest
Deal found 7/15![Southwest logo]()
$324
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:11 pm
DSM
- SFO
1 stop9h 46m
Delta
Thu 10/18:59 pm
SFO
- DSM
2 stops11h 18m
Delta
Deal found 7/15![Delta logo]()
$392
This Frontier deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/312:19 pm
DSM
- SFO
1 stop12h 04m
Frontier
Mon 8/36:00 am
SFO
- DSM
1 stop5h 34m
Frontier
Deal found 7/12![Frontier logo]()
$427
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:50 pm
DSM
- SFO
1 stop7h 09m
American Airlines
Tue 8/411:20 pm
SFO
- DSM
1 stop7h 41m
American Airlines
Deal found 7/12![American Airlines logo]()
$444
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/143:50 pm
DSM
- SFO
1 stop9h 55m
Southwest
Tue 9/151:25 pm
SFO
- DSM
1 stop5h 35m
Southwest
Deal found 7/14![Southwest logo]()
$350
This Southwest deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/102:25 pm
DSM
- SFO
2 stops8h 05m
Southwest
Mon 9/1410:50 am
SFO
- DSM
2 stops8h 25m
Southwest
Deal found 7/16![Southwest logo]()
$379
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:30 pm
DSM
- SFO
1 stop6h 52m
Delta
Mon 11/236:00 am
SFO
- DSM
2 stops13h 24m
Delta
Deal found 7/14![Delta logo]()
$419
This Southwest deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:45 am
DSM
- SFO
2 stops9h 00m
Southwest
Tue 10/208:10 am
SFO
- DSM
2 stops7h 40m
Southwest
Deal found 7/12![Southwest logo]()
$394
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:10 pm
DSM
- SFO
1 stop6h 00m
Southwest
Mon 10/126:45 am
SFO
- DSM
1 stop9h 45m
Southwest
Deal found 7/17![Southwest logo]()
$407
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/42:25 pm
DSM
- SFO
2 stops9h 05m
Southwest
Tue 9/86:35 am
SFO
- DSM
1 stop5h 20m
Southwest
Deal found 7/17![Southwest logo]()
$407
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/222:00 pm
DSM
- SFO
2 stops9h 05m
Southwest
Mon 10/2610:55 am
SFO
- DSM
2 stops9h 00m
Southwest
Deal found 7/17![Southwest logo]()
$412
Last-minute flights from Des Moines to San FranciscoDiscover last-minute flight deals from Des Moines to San Francisco. Data last updated July 18, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Francisco. Data last updated July 18, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:06 pm
DSM
- SFO
1 stop14h 19m
Multiple Airlines
Wed 8/198:56 pm
SFO
- DSM
1 stop22h 04m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$196
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:06 pm
DSM
- SFO
1 stop19h 14m
Multiple Airlines
Thu 8/2011:00 am
SFO
- DSM
1 stop8h 00m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$202
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1410:06 pm
DSM
- SFO
1 stop12h 37m
Multiple Airlines
Wed 8/198:56 pm
SFO
- DSM
1 stop22h 04m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1410:06 pm
DSM
- SFO
1 stop12h 37m
Multiple Airlines
Thu 8/2011:00 am
SFO
- DSM
1 stop8h 00m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SFO
1 stop23h 50m
Multiple Airlines
Mon 8/2411:00 am
SFO
- DSM
1 stop6h 48m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SFO
1 stop14h 19m
Multiple Airlines
Thu 8/2011:00 am
SFO
- DSM
1 stop8h 00m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:54 pm
DSM
- SFO
2 stops25h 46m
Multiple Airlines
Thu 9/38:56 pm
SFO
- DSM
1 stop12h 14m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$216
One-way flights from Des Moines to San FranciscoSearch for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 18, 2026.
Search for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:31 pm
DSM
- SFO
1 stop15h 15m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$91
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:38 pm
DSM
- SFO
1 stop15h 47m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$93
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:42 pm
DSM
- SFO
1 stop11h 03m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/309:50 pm
DSM
- SFO
1 stop20h 46m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/119:31 pm
DSM
- SFO
1 stop15h 15m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/209:56 pm
DSM
- SFO
1 stop12h 27m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$120
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:00 am
DSM
- SFO
2 stops17h 45m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/79:21 pm
DSM
- SFO
2 stops22h 57m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:00 am
DSM
- SFO
2 stops36h 22m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:19 pm
DSM
- SFO
2 stops20h 24m
Frontier
Deal found 7/12![Frontier logo]()
$128
Find flight deals from Des Moines to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $183 (Kiwi.com) |
One-way from | $91 (Kiwi.com) |
Popular in | June |
Cheapest in | February |
Average price | $506 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 18, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sat 8/29
4:50 pm-9:25 pm
1 stop6h 35m
San Francisco
Sat 9/5
6:25 am-8:45 pm
2 stops12h 20m
$324
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Mon 9/14
3:50 pm-11:45 pm
1 stop9h 55m
San Francisco
Tue 9/15
1:25 pm-9:00 pm
1 stop5h 35m
$350
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Mon 8/10
2:25 pm-8:30 pm
2 stops8h 05m
San Francisco
Mon 9/14
10:50 am-9:15 pm
2 stops8h 25m
$379
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 9/9
4:11 pm-11:57 pm
1 stop9h 46m
San Francisco
Thu 10/1
8:59 pm-10:17 am
2 stops11h 18m
$392
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sun 10/18
6:45 am-1:45 pm
2 stops9h 00m
San Francisco
Tue 10/20
8:10 am-5:50 pm
2 stops7h 40m
$394
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 10/8
7:10 pm-11:10 pm
1 stop6h 00m
San Francisco
Mon 10/12
6:45 am-6:30 pm
1 stop9h 45m
$407
Quickest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Fri 9/4
2:25 pm-9:30 pm
2 stops9h 05m
San Francisco
Tue 9/8
6:35 am-1:55 pm
1 stop5h 20m
$407
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 10/22
2:00 pm-9:05 pm
2 stops9h 05m
San Francisco
Mon 10/26
10:55 am-9:55 pm
2 stops9h 00m
$412
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 11/18
3:30 pm-8:22 pm
1 stop6h 52m
San Francisco
Mon 11/23
6:00 am-9:24 pm
2 stops13h 24m
$419
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Fri 7/31
2:19 pm-12:23 am
1 stop12h 04m
San Francisco
Mon 8/3
6:00 am-1:34 pm
1 stop5h 34m
$427
Showing 1-10 of 23 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Francisco in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Des Moines with our price prediction graph.
DSM-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Francisco
Prices
Delays
More
How far ahead should I book a flight from Des Moines to San Francisco?
Booking 57 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Des Moines to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Des Moines to San Francisco (average of $367). Flying from Des Moines to San Francisco in June is currently the most expensive (average of $566). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Francisco?
How often are flights from Des Moines to San Francisco delayed?
About 33% of weekly flights between Des Moines and San Francisco have experienced delays in the past year, with the average delay time being 40 minutes.
What is the most punctual flight time for Des Moines to San Francisco flights?
Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What’s the top layover airport for flights from Des Moines to San Francisco?
Share of 1-stop round-trip flights from Des Moines to San Francisco chosen by Cheapflights users in the past 12 months, using the same layover each way.
Denver (DEN) – chosen by Cheapflights users on 75% of 1-stop itineraries from Des Moines to San Francisco on Cheapflights.
What’s the cheapest layover airport for flights from Des Moines to San Francisco?
Average round-trip fare for 1-stop flights from Des Moines to San Francisco, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Denver (DEN) is the most affordable 1-stop option, with an average round-trip price of $298.
What’s the fastest layover option from Des Moines to San Francisco?
Shortest average travel time for 1-stop one-way flights from Des Moines to San Francisco, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 5h 41m.
Which airport typically offers the quickest layover for flights from Des Moines to San Francisco?
Average layover duration for 1-stop one-way flights from Des Moines to San Francisco, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 03m.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated July 18, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
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San Bruno
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Des Moines and San Francisco flights
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Top 5 airlines flying from Des Moines to San Francisco
Discover the top 5 airlines that operate flights from Des Moines to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$120 | Average$297 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$274 | Average$502 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$321 | Average$511 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$344 | Average$493 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$346 | Average$463 | FlexibilityNo cancel fee | On-time71% |