$128+ Cheap flights from Des Moines to San Francisco (DSM - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Jun 17 — Jun 241
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to San FranciscoExplore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 18, 2026.
Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/59:56 pm
DSM
- SFO
1 stop18h 30m
Multiple Airlines
Tue 6/910:58 pm
SFO
- DSM
1 stop11h 57m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1710:01 pm
DSM
- SFO
1 stop12h 42m
Multiple Airlines
Tue 7/2111:10 am
SFO
- DSM
2 stops23h 49m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3110:01 pm
DSM
- SFO
1 stop12h 42m
Multiple Airlines
Tue 8/2510:06 pm
SFO
- DSM
2 stops44h 54m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:38 pm
DSM
- SFO
1 stop15h 08m
Multiple Airlines
Tue 8/2510:06 pm
SFO
- DSM
2 stops44h 54m
Multiple Airlines
Deal found 5/17![Multiple Airlines logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/179:56 pm
DSM
- SFO
1 stop17h 21m
Multiple Airlines
Sun 9/207:30 pm
SFO
- DSM
2 stops16h 26m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$285
This Expedia deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/52:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Mon 6/86:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/13![Frontier logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3110:01 pm
DSM
- SFO
1 stop12h 42m
Multiple Airlines
Sun 8/2310:50 pm
SFO
- DSM
1 stop18h 58m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:17 pm
DSM
- SFO
2 stops24h 19m
Multiple Airlines
Thu 6/410:50 pm
SFO
- DSM
1 stop20h 16m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/169:33 pm
DSM
- SFO
1 stop24h 20m
Multiple Airlines
Tue 7/2111:10 am
SFO
- DSM
2 stops23h 49m
Multiple Airlines
Deal found 5/14![Multiple Airlines logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/279:30 am
DSM
- SFO
1 stop7h 29m
Multiple Airlines
Tue 7/710:56 pm
SFO
- DSM
1 stop12h 03m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/59:56 pm
DSM
- SFO
1 stop18h 30m
Multiple Airlines
Wed 6/1011:13 am
SFO
- DSM
2 stops30h 33m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$300
Best flights from Des Moines to San FranciscoDiscover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 18, 2026.
Discover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 18, 2026.
This Southwest deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/13:45 pm
DSM
- SFO
2 stops8h 40m
Southwest
Wed 7/88:55 am
SFO
- DSM
2 stops10h 45m
Southwest
Deal found 5/17![Southwest logo]()
$405
This Delta deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1210:55 am
DSM
- SFO
1 stop9h 13m
Delta
Fri 9/1810:30 pm
SFO
- DSM
1 stop9h 44m
Delta
Deal found 5/17![Delta logo]()
$444
This Southwest deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2112:05 pm
DSM
- SFO
2 stops9h 40m
Southwest
Mon 10/266:05 am
SFO
- DSM
2 stops7h 45m
Southwest
Deal found 5/14![Southwest logo]()
$418
This Southwest deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:10 am
DSM
- SFO
2 stops7h 10m
Southwest
Thu 7/29:25 am
SFO
- DSM
2 stops10h 55m
Southwest
Deal found 5/13![Southwest logo]()
$431
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/11:50 pm
DSM
- SFO
2 stops8h 30m
Southwest
Mon 10/56:05 am
SFO
- DSM
2 stops7h 45m
Southwest
Deal found 5/15![Southwest logo]()
$431
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/172:25 pm
DSM
- SFO
2 stops8h 05m
Southwest
Mon 9/219:55 am
SFO
- DSM
2 stops9h 20m
Southwest
Deal found 5/15![Southwest logo]()
$431
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3012:10 pm
DSM
- SFO
1 stop8h 30m
Southwest
Tue 7/710:25 am
SFO
- DSM
2 stops9h 15m
Southwest
Deal found 5/15![Southwest logo]()
$436
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/276:10 am
DSM
- SFO
2 stops9h 00m
Southwest
Tue 7/78:55 am
SFO
- DSM
2 stops10h 45m
Southwest
Deal found 5/15![Southwest logo]()
$441
This Southwest deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:10 am
DSM
- SFO
2 stops8h 50m
Southwest
Tue 7/215:50 am
SFO
- DSM
2 stops10h 30m
Southwest
Deal found 5/15![Southwest logo]()
$441
This Southwest deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/102:25 pm
DSM
- SFO
2 stops8h 05m
Southwest
Fri 8/148:30 am
SFO
- DSM
2 stops10h 45m
Southwest
Deal found 5/16![Southwest logo]()
$454
This Southwest deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/216:10 am
DSM
- SFO
2 stops7h 50m
Southwest
Wed 6/245:50 am
SFO
- DSM
2 stops10h 30m
Southwest
Deal found 5/13![Southwest logo]()
$463
Last-minute flights from Des Moines to San FranciscoDiscover last-minute flight deals from Des Moines to San Francisco. Data last updated May 18, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Francisco. Data last updated May 18, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:17 pm
DSM
- SFO
2 stops24h 19m
Multiple Airlines
Thu 6/410:50 pm
SFO
- DSM
1 stop20h 16m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:17 pm
DSM
- SFO
1 stop15h 13m
Multiple Airlines
Tue 8/411:10 am
SFO
- DSM
2 stops23h 49m
Multiple Airlines
Deal found 5/14![Multiple Airlines logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:17 pm
DSM
- SFO
1 stop15h 13m
Multiple Airlines
Tue 6/910:58 pm
SFO
- DSM
1 stop11h 57m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$315
This Expedia deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Mon 6/86:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/14![Frontier logo]()
$304
This Frontier deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Wed 6/106:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/16![Frontier logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/59:56 pm
DSM
- SFO
1 stop18h 30m
Multiple Airlines
Tue 6/910:58 pm
SFO
- DSM
1 stop11h 57m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$271
This Expedia deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/52:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Mon 6/86:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 5/13![Frontier logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/59:56 pm
DSM
- SFO
1 stop18h 30m
Multiple Airlines
Wed 6/1011:13 am
SFO
- DSM
2 stops30h 33m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$300
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/279:30 am
DSM
- SFO
1 stop7h 29m
Multiple Airlines
Tue 7/710:56 pm
SFO
- DSM
1 stop12h 03m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/299:56 pm
DSM
- SFO
1 stop14h 32m
Multiple Airlines
Wed 7/810:56 pm
SFO
- DSM
2 stops15h 11m
Multiple Airlines
Deal found 5/14![Multiple Airlines logo]()
$305
One-way flights from Des Moines to San FranciscoSearch for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 18, 2026.
Search for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:56 pm
DSM
- SFO
1 stop18h 20m
Multiple Airlines
Deal found 5/16![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/610:01 pm
DSM
- SFO
2 stops26h 08m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$139
This Frontier deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/102:16 pm
DSM
- SFO
1 stop12h 11m
Frontier
Deal found 5/13![Frontier logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:01 pm
DSM
- SFO
1 stop14h 53m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$148
This Expedia deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/122:16 pm
DSM
- SFO
1 stop12h 11m
Frontier
Deal found 5/13![Frontier logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/59:56 pm
DSM
- SFO
1 stop18h 30m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$152
This Kiwi.com deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:00 am
DSM
- SFO
2 stops38h 35m
Multiple Airlines
Deal found 5/13![Multiple Airlines logo]()
$159
This Expedia deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Deal found 5/13![Frontier logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/289:34 pm
DSM
- SFO
1 stop13h 15m
Multiple Airlines
Deal found 5/14![Multiple Airlines logo]()
$171
Find flight deals from Des Moines to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $271 (Kiwi.com) |
One-way from | $128 (Kiwi.com) |
Popular in | March |
Cheapest in | February |
Average price | $496 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 18, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 7/1
3:45 pm-10:25 pm
2 stops8h 40m
San Francisco
Wed 7/8
8:55 am-9:40 pm
2 stops10h 45m
$405
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 10/21
12:05 pm-7:45 pm
2 stops9h 40m
San Francisco
Mon 10/26
6:05 am-3:50 pm
2 stops7h 45m
$418
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 6/11
6:10 am-11:20 am
2 stops7h 10m
San Francisco
Thu 7/2
9:25 am-10:20 pm
2 stops10h 55m
$431
Quickest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 10/1
1:50 pm-8:20 pm
2 stops8h 30m
San Francisco
Mon 10/5
6:05 am-3:50 pm
2 stops7h 45m
$431
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 9/17
2:25 pm-8:30 pm
2 stops8h 05m
San Francisco
Mon 9/21
9:55 am-9:15 pm
2 stops9h 20m
$431
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Tue 6/30
12:10 pm-6:40 pm
1 stop8h 30m
San Francisco
Tue 7/7
10:25 am-9:40 pm
2 stops9h 15m
$436
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sat 6/27
6:10 am-1:10 pm
2 stops9h 00m
San Francisco
Tue 7/7
8:55 am-9:40 pm
2 stops10h 45m
$441
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Fri 7/17
6:10 am-1:00 pm
2 stops8h 50m
San Francisco
Tue 7/21
5:50 am-6:20 pm
2 stops10h 30m
$441
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sat 9/12
10:55 am-6:08 pm
1 stop9h 13m
San Francisco
Fri 9/18
10:30 pm-10:14 am
1 stop9h 44m
$444
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Mon 8/10
2:25 pm-8:30 pm
2 stops8h 05m
San Francisco
Fri 8/14
8:30 am-9:15 pm
2 stops10h 45m
$454
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Francisco in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Des Moines with our price prediction graph.
DSM-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Francisco
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How far ahead should I book a flight from Des Moines to San Francisco?
Booking 57 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Des Moines to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Des Moines to San Francisco (average of $365). Flying from Des Moines to San Francisco in March is currently the most expensive (average of $496). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Francisco?
How often are flights from Des Moines to San Francisco delayed?
About 0% of weekly flights between Des Moines and San Francisco have experienced delays in the past year, with the average delay time being 0 minutes.
What is the most punctual flight time for Des Moines to San Francisco flights?
Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What’s the top layover airport for flights from Des Moines to San Francisco?
Share of 1-stop round-trip flights from Des Moines to San Francisco chosen by Cheapflights users in the past 12 months, using the same layover each way.
Dallas (DFW) – chosen by Cheapflights users on 50% of 1-stop itineraries from Des Moines to San Francisco on Cheapflights.
What’s the cheapest layover airport for flights from Des Moines to San Francisco?
Average round-trip fare for 1-stop flights from Des Moines to San Francisco, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $381.
What’s the fastest layover option from Des Moines to San Francisco?
Shortest average travel time for 1-stop one-way flights from Des Moines to San Francisco, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 5h 40m.
Which airport typically offers the quickest layover for flights from Des Moines to San Francisco?
Average layover duration for 1-stop one-way flights from Des Moines to San Francisco, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 05m.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated May 18, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
7.9
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
7.9
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
7.9
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
7.9
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
7.9
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Entertainment
7.5
Crew
8.6
Overall
7.9
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Fairfield
Rancho Cordova
San Bruno
Watsonville
San Ramon
Vacaville
Roseville
San Carlos
Redwood City
Sunnyvale
Turlock
Vallejo
San Lorenzo
Davis
Emeryville
Manteca
Elk Grove
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Des Moines and San Francisco flights
Browse other Des Moines and San Francisco flight options. Last updated on May 18, 2026.
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Top 5 airlines flying from Des Moines to San Francisco
Discover the top 5 airlines that operate flights from Des Moines to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$120 | Average$260 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$263 | Average$372 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$321 | Average$515 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$336 | Average$476 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$350 | Average$428 | FlexibilityNo cancel fee | On-time71% |