$112+ Cheap flights from Des Moines to San Francisco (DSM - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Jul 29 — Aug 51
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to San Francisco
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Cheapest flights from Des Moines to San FranciscoExplore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 29, 2026.
Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:06 pm
DSM
- SFO
1 stop25h 06m
Multiple Airlines
Wed 8/268:56 pm
SFO
- DSM
1 stop22h 04m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:06 pm
DSM
- SFO
1 stop19h 14m
Multiple Airlines
Wed 8/198:56 pm
SFO
- DSM
1 stop22h 04m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1410:06 pm
DSM
- SFO
1 stop20h 30m
Multiple Airlines
Wed 8/198:56 pm
SFO
- DSM
1 stop22h 04m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:31 pm
DSM
- SFO
1 stop28h 14m
Multiple Airlines
Fri 9/186:30 am
SFO
- DSM
1 stop11h 18m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:31 pm
DSM
- SFO
1 stop15h 15m
Multiple Airlines
Tue 9/2911:42 am
SFO
- DSM
1 stop24h 10m
Multiple Airlines
Deal found 6/27![Multiple Airlines logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/119:31 pm
DSM
- SFO
1 stop15h 15m
Multiple Airlines
Fri 9/186:30 am
SFO
- DSM
1 stop11h 18m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:31 pm
DSM
- SFO
1 stop28h 14m
Multiple Airlines
Thu 9/1711:42 am
SFO
- DSM
1 stop7h 24m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$240
This Frontier deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:19 pm
DSM
- SFO
1 stop11h 59m
Frontier
Wed 8/126:00 am
SFO
- DSM
1 stop5h 34m
Frontier
Deal found 6/25![Frontier logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:38 pm
DSM
- SFO
1 stop15h 47m
Multiple Airlines
Wed 8/268:56 pm
SFO
- DSM
1 stop22h 04m
Multiple Airlines
Deal found 6/25![Multiple Airlines logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:06 pm
DSM
- SFO
1 stop19h 14m
Multiple Airlines
Mon 8/1711:20 am
SFO
- DSM
1 stop7h 56m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:06 pm
DSM
- SFO
1 stop19h 14m
Multiple Airlines
Thu 8/139:05 pm
SFO
- DSM
1 stop22h 11m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$253
Best flights from Des Moines to San FranciscoDiscover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 29, 2026.
Discover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 29, 2026.
This Southwest deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/123:05 pm
DSM
- SFO
1 stop7h 30m
Southwest
Sat 9/196:25 am
SFO
- DSM
2 stops7h 45m
Southwest
Deal found 6/28![Southwest logo]()
$306
This Delta deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:56 pm
DSM
- SFO
1 stop7h 51m
Delta
Sun 8/3012:12 am
SFO
- DSM
1 stop8h 06m
Delta
Deal found 6/25![Delta logo]()
$381
This Southwest deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:25 pm
DSM
- SFO
2 stops9h 05m
Southwest
Mon 9/148:30 am
SFO
- DSM
2 stops10h 45m
Southwest
Deal found 6/27![Southwest logo]()
$332
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:40 pm
DSM
- SFO
1 stop6h 35m
Southwest
Thu 8/278:30 am
SFO
- DSM
2 stops10h 45m
Southwest
Deal found 6/24![Southwest logo]()
$377
This Southwest deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/102:25 pm
DSM
- SFO
2 stops8h 05m
Southwest
Mon 8/1710:50 am
SFO
- DSM
2 stops8h 25m
Southwest
Deal found 6/28![Southwest logo]()
$407
This Southwest deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:50 pm
DSM
- SFO
1 stop9h 55m
Southwest
Sun 8/1611:05 am
SFO
- DSM
2 stops8h 25m
Southwest
Deal found 6/28![Southwest logo]()
$407
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:20 am
DSM
- SFO
2 stops9h 25m
Southwest
Sat 8/156:25 am
SFO
- DSM
2 stops7h 45m
Southwest
Deal found 6/24![Southwest logo]()
$412
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:25 pm
DSM
- SFO
1 stop6h 50m
Southwest
Sun 9/136:50 am
SFO
- DSM
1 stop6h 25m
Southwest
Deal found 6/25![Southwest logo]()
$424
This Southwest deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/142:25 pm
DSM
- SFO
2 stops9h 05m
Southwest
Mon 8/1711:05 am
SFO
- DSM
2 stops8h 10m
Southwest
Deal found 6/28![Southwest logo]()
$442
Last-minute flights from Des Moines to San FranciscoDiscover last-minute flight deals from Des Moines to San Francisco. Data last updated June 29, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Francisco. Data last updated June 29, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/93:42 pm
DSM
- SFO
2 stops34h 41m
Multiple Airlines
Thu 7/1611:20 am
SFO
- DSM
1 stop7h 23m
Multiple Airlines
Deal found 6/27![Multiple Airlines logo]()
$490
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/99:33 pm
DSM
- SFO
1 stop21h 08m
Multiple Airlines
Mon 7/1310:23 pm
SFO
- DSM
2 stops36h 36m
Multiple Airlines
Deal found 6/26![Multiple Airlines logo]()
$578
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:37 am
DSM
- SFO
1 stop6h 01m
American Airlines
Sun 7/126:45 am
SFO
- DSM
1 stop7h 15m
American Airlines
Deal found 6/25![American Airlines logo]()
$587
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/92:25 pm
DSM
- SFO
1 stop9h 23m
Delta
Sun 7/1211:56 pm
SFO
- DSM
1 stop7h 49m
Delta
Deal found 6/29![Delta logo]()
$782
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/99:14 am
DSM
- SFO
2 stops12h 56m
United Airlines
Sun 7/126:15 am
SFO
- DSM
1 stop8h 00m
United Airlines
Deal found 6/28![United Airlines logo]()
$794
This Southwest deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/91:30 pm
DSM
- SFO
2 stops9h 15m
Southwest
Mon 7/139:45 am
SFO
- DSM
2 stops10h 40m
Southwest
Deal found 6/26![Southwest logo]()
$842
This Alaska Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/99:41 am
DSM
- SFO
2 stops12h 31m
Alaska Airlines
Sun 7/127:55 am
SFO
- DSM
2 stops14h 03m
Alaska Airlines
Deal found 6/29![Alaska Airlines logo]()
$1,287
One-way flights from Des Moines to San FranciscoSearch for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated June 29, 2026.
Search for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated June 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:31 pm
DSM
- SFO
1 stop15h 15m
Multiple Airlines
Deal found 6/24![Multiple Airlines logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/318:54 pm
DSM
- SFO
1 stop25h 02m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2710:01 pm
DSM
- SFO
1 stop14h 29m
Multiple Airlines
Deal found 6/27![Multiple Airlines logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3110:01 pm
DSM
- SFO
1 stop12h 47m
Multiple Airlines
Deal found 6/25![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/310:01 pm
DSM
- SFO
1 stop14h 29m
Multiple Airlines
Deal found 6/25![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1310:01 pm
DSM
- SFO
2 stops25h 37m
Multiple Airlines
Deal found 6/24![Multiple Airlines logo]()
$129
This Frontier deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/292:19 pm
DSM
- SFO
1 stop12h 04m
Frontier
Deal found 6/27![Frontier logo]()
$137
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/47:13 pm
DSM
- SFO
1 stop7h 30m
American Airlines
Deal found 6/27![American Airlines logo]()
$151
This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:35 pm
DSM
- SFO
1 stop6h 36m
American Airlines
Deal found 6/26![American Airlines logo]()
$154
Find flight deals from Des Moines to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $180 (Kiwi.com) |
One-way from | $112 (Kiwi.com) |
Popular in | June |
Cheapest in | September |
Average price | $566 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 29, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sat 9/12
3:05 pm-8:35 pm
1 stop7h 30m
San Francisco
Sat 9/19
6:25 am-4:10 pm
2 stops7h 45m
$306
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 9/10
2:25 pm-9:30 pm
2 stops9h 05m
San Francisco
Mon 9/14
8:30 am-9:15 pm
2 stops10h 45m
$332
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Tue 8/25
6:40 pm-11:15 pm
1 stop6h 35m
San Francisco
Thu 8/27
8:30 am-9:15 pm
2 stops10h 45m
$377
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 8/27
5:56 pm-11:47 pm
1 stop7h 51m
San Francisco
Sun 8/30
12:12 am-10:18 am
1 stop8h 06m
$381
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Mon 8/10
2:25 pm-8:30 pm
2 stops8h 05m
San Francisco
Mon 8/17
10:50 am-9:15 pm
2 stops8h 25m
$407
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 8/13
3:50 pm-11:45 pm
1 stop9h 55m
San Francisco
Sun 8/16
11:05 am-9:30 pm
2 stops8h 25m
$407
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sat 8/8
7:20 am-2:45 pm
2 stops9h 25m
San Francisco
Sat 8/15
6:25 am-4:10 pm
2 stops7h 45m
$412
Quickest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 9/10
2:25 pm-7:15 pm
1 stop6h 50m
San Francisco
Sun 9/13
6:50 am-3:15 pm
1 stop6h 25m
$424
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Fri 8/14
2:25 pm-9:30 pm
2 stops9h 05m
San Francisco
Mon 8/17
11:05 am-9:15 pm
2 stops8h 10m
$442
Cheapest one-way
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Mon 8/31
8:54 pm-7:56 pm
1 stop25h 02m
$122
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Francisco in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Des Moines with our price prediction graph.
DSM-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Francisco
Prices
Delays
More
How far ahead should I book a flight from Des Moines to San Francisco?
Booking 57 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Des Moines to San Francisco?
Currently, September is the cheapest month in which you can book a flight from Des Moines to San Francisco (average of $366). Flying from Des Moines to San Francisco in June is currently the most expensive (average of $566). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Francisco?
How often are flights from Des Moines to San Francisco delayed?
About 25% of weekly flights between Des Moines and San Francisco have experienced delays in the past year, with the average delay time being 40 minutes.
What is the most punctual flight time for Des Moines to San Francisco flights?
Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What’s the top layover airport for flights from Des Moines to San Francisco?
Share of 1-stop round-trip flights from Des Moines to San Francisco chosen by Cheapflights users in the past 12 months, using the same layover each way.
Dallas (DFW) – chosen by Cheapflights users on 50% of 1-stop itineraries from Des Moines to San Francisco on Cheapflights.
What’s the cheapest layover airport for flights from Des Moines to San Francisco?
Average round-trip fare for 1-stop flights from Des Moines to San Francisco, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $381.
What’s the fastest layover option from Des Moines to San Francisco?
Shortest average travel time for 1-stop one-way flights from Des Moines to San Francisco, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 5h 40m.
Which airport typically offers the quickest layover for flights from Des Moines to San Francisco?
Average layover duration for 1-stop one-way flights from Des Moines to San Francisco, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 05m.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated June 29, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.0
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Food
7.0
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Food
7.0
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Food
7.0
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Food
7.0
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Boarding
8.1
Food
7.0
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
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Fairfield
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Rancho Cordova
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Emeryville
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San Bruno
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San Ramon
San Carlos
Daly City
Turlock
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Des Moines and San Francisco flights
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Top 5 airlines flying from Des Moines to San Francisco
Discover the top 5 airlines that operate flights from Des Moines to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$120 | Average$290 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$263 | Average$466 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$321 | Average$511 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$336 | Average$466 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$371 | Average$492 | FlexibilityNo cancel fee | On-time63% |