$130+ Cheap flights from Des Moines to San Francisco (DSM - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/18. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Sep 2 — Sep 91
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to San FranciscoExplore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 3, 2026.
Explore the most affordable flight options available from Des Moines to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:31 pm
DSM
- SFO
1 stop12h 43m
Multiple Airlines
Tue 9/293:15 pm
SFO
- DSM
1 stop20h 37m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:31 pm
DSM
- SFO
1 stop18h 58m
Multiple Airlines
Thu 10/110:24 pm
SFO
- DSM
1 stop10h 33m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$193
This Frontier deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:19 pm
DSM
- SFO
1 stop6h 26m
Frontier
Mon 8/316:00 am
SFO
- DSM
1 stop5h 34m
Frontier
Deal found 7/30![Frontier logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm
DSM
- SFO
1 stop18h 58m
Multiple Airlines
Tue 10/67:11 pm
SFO
- DSM
1 stop16h 41m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:50 pm
DSM
- SFO
1 stop12h 53m
Multiple Airlines
Thu 8/273:38 pm
SFO
- DSM
1 stop25h 10m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$206
This CheapOair deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:29 am
DSM
- SFO
1 stop14h 45m
Frontier
Mon 9/1411:42 am
SFO
- DSM
1 stop5h 51m
Frontier
Deal found 7/30![Frontier logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:38 pm
DSM
- SFO
1 stop15h 05m
Multiple Airlines
Thu 8/273:38 pm
SFO
- DSM
1 stop25h 10m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm
DSM
- SFO
1 stop18h 58m
Multiple Airlines
Fri 10/910:06 pm
SFO
- DSM
1 stop14h 31m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:31 pm
DSM
- SFO
1 stop18h 58m
Multiple Airlines
Thu 10/810:06 pm
SFO
- DSM
1 stop12h 31m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$220
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:42 pm
DSM
- SFO
1 stop19h 32m
Multiple Airlines
Wed 10/73:15 pm
SFO
- DSM
1 stop25h 27m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$221
Best flights from Des Moines to San FranciscoDiscover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 3, 2026.
Discover carefully curated flight deals from Des Moines to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 3, 2026.
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/123:05 pm
DSM
- SFO
1 stop7h 35m
Southwest
Sat 9/196:40 am
SFO
- DSM
1 stop5h 30m
Southwest
Deal found 7/29![Southwest logo]()
$301
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:00 am
DSM
- SFO
2 stops17h 21m
Delta
Tue 9/156:35 am
SFO
- DSM
1 stop5h 31m
Delta
Deal found 8/2![Delta logo]()
$385
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/66:55 am
DSM
- SFO
2 stops9h 00m
Southwest
Tue 1/1210:10 am
SFO
- DSM
2 stops8h 30m
Southwest
Deal found 7/29![Southwest logo]()
$311
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:40 pm
DSM
- SFO
1 stop6h 40m
Southwest
Wed 9/236:35 am
SFO
- DSM
1 stop5h 20m
Southwest
Deal found 8/2![Southwest logo]()
$325
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:55 am
DSM
- SFO
1 stop5h 57m
Delta
Wed 10/2112:10 am
SFO
- DSM
1 stop8h 01m
Delta
Deal found 8/1![Delta logo]()
$392
This Southwest deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:00 am
DSM
- SFO
1 stop8h 50m
Southwest
Wed 12/910:25 am
SFO
- DSM
2 stops8h 20m
Southwest
Deal found 8/1![Southwest logo]()
$330
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/242:25 pm
DSM
- SFO
2 stops8h 10m
Southwest
Tue 9/295:50 am
SFO
- DSM
2 stops9h 55m
Southwest
Deal found 7/30![Southwest logo]()
$361
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:25 pm
DSM
- SFO
2 stops9h 05m
Southwest
Thu 9/38:30 am
SFO
- DSM
2 stops10h 50m
Southwest
Deal found 7/30![Southwest logo]()
$361
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:25 pm
DSM
- SFO
2 stops9h 05m
Southwest
Sun 9/1310:50 am
SFO
- DSM
2 stops8h 45m
Southwest
Deal found 7/31![Southwest logo]()
$399
Last-minute flights from Des Moines to San FranciscoDiscover last-minute flight deals from Des Moines to San Francisco. Data last updated August 3, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Francisco. Data last updated August 3, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:38 pm
DSM
- SFO
1 stop15h 05m
Multiple Airlines
Thu 8/273:38 pm
SFO
- DSM
1 stop25h 10m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:50 pm
DSM
- SFO
1 stop12h 53m
Multiple Airlines
Thu 8/273:38 pm
SFO
- DSM
1 stop25h 10m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:50 pm
DSM
- SFO
1 stop12h 53m
Multiple Airlines
Fri 8/286:00 am
SFO
- DSM
1 stop5h 34m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:50 pm
DSM
- SFO
1 stop12h 53m
Multiple Airlines
Wed 9/28:56 pm
SFO
- DSM
1 stop22h 15m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:50 pm
DSM
- SFO
1 stop12h 53m
Multiple Airlines
Sun 8/307:30 pm
SFO
- DSM
1 stop16h 04m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$260
This Frontier deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:19 pm
DSM
- SFO
1 stop6h 26m
Frontier
Mon 8/316:00 am
SFO
- DSM
1 stop5h 34m
Frontier
Deal found 7/30![Frontier logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:38 pm
DSM
- SFO
1 stop25h 18m
Multiple Airlines
Thu 8/278:56 pm
SFO
- DSM
1 stop19h 52m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:38 pm
DSM
- SFO
1 stop25h 18m
Multiple Airlines
Fri 8/286:00 am
SFO
- DSM
1 stop5h 34m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:38 pm
DSM
- SFO
1 stop25h 18m
Multiple Airlines
Wed 9/28:56 pm
SFO
- DSM
1 stop22h 15m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:00 am
DSM
- SFO
2 stops18h 18m
Multiple Airlines
Thu 9/310:59 pm
SFO
- DSM
1 stop10h 11m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$246
One-way flights from Des Moines to San FranciscoSearch for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated August 3, 2026.
Search for one-way flight options from Des Moines to San Francisco. Find affordable one-way fares based on user searches. Data last updated August 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:38 pm
DSM
- SFO
1 stop13h 36m
Multiple Airlines
Deal found 8/1![Multiple Airlines logo]()
$130
This Priceline deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:30 pm
DSM
- SFO
1 stop5h 44m
Frontier
Deal found 7/30![Frontier logo]()
$131
This CheapOair deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:29 am
DSM
- SFO
1 stop14h 45m
Frontier
Deal found 8/1![Frontier logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1810:09 pm
DSM
- SFO
2 stops46h 13m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$143
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2711:29 am
DSM
- SFO
1 stop14h 45m
Frontier
Deal found 8/2![Frontier logo]()
$144
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1812:53 pm
DSM
- SFO
2 stops45h 19m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$148
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/129:51 am
DSM
- SFO
1 stop7h 10m
American Airlines
Deal found 7/29![American Airlines logo]()
$151
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1212:10 pm
DSM
- SFO
2 stops10h 30m
Southwest
Deal found 7/29![Southwest logo]()
$156
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1710:06 pm
DSM
- SFO
1 stop23h 50m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:00 am
DSM
- SFO
2 stops18h 18m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$163
Find flight deals from Des Moines to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $190 (Kiwi.com) |
One-way from | $130 (Kiwi.com) |
Popular in | June |
Cheapest in | February |
Average price | $456 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 3, 2026.
Use the filters below to find and compare flights from Des Moines to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Sat 9/12
3:05 pm-8:40 pm
1 stop7h 35m
San Francisco
Sat 9/19
6:40 am-2:10 pm
1 stop5h 30m
$301
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 1/6
6:55 am-1:55 pm
2 stops9h 00m
San Francisco
Tue 1/12
10:10 am-8:40 pm
2 stops8h 30m
$311
Quickest round-trip
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 9/16
6:40 pm-11:20 pm
1 stop6h 40m
San Francisco
Wed 9/23
6:35 am-1:55 pm
1 stop5h 20m
$325
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Mon 12/7
6:00 am-12:50 pm
1 stop8h 50m
San Francisco
Wed 12/9
10:25 am-8:45 pm
2 stops8h 20m
$330
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 9/24
2:25 pm-8:35 pm
2 stops8h 10m
San Francisco
Tue 9/29
5:50 am-5:45 pm
2 stops9h 55m
$361
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 8/27
2:25 pm-9:30 pm
2 stops9h 05m
San Francisco
Thu 9/3
8:30 am-9:20 pm
2 stops10h 50m
$361
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 9/9
7:00 am-10:21 pm
2 stops17h 21m
San Francisco
Tue 9/15
6:35 am-2:06 pm
1 stop5h 31m
$385
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Tue 10/20
6:55 am-10:52 am
1 stop5h 57m
San Francisco
Wed 10/21
12:10 am-10:11 am
1 stop8h 01m
$392
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Fri 9/11
2:25 pm-9:30 pm
2 stops9h 05m
San Francisco
Sun 9/13
10:50 am-9:35 pm
2 stops8h 45m
$399
Cheapest one-way
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Thu 9/17
11:29 am-12:14 am
1 stop14h 45m
$142
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Francisco in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Des Moines with our price prediction graph.
DSM-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Francisco
Prices
Delays
More
How far ahead should I book a flight from Des Moines to San Francisco?
Booking 26 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Des Moines to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Des Moines to San Francisco (average of $367). Flying from Des Moines to San Francisco in June is currently the most expensive (average of $566). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Francisco?
Airfare is below average for this route at the moment.
Des Moines to San Francisco flights typically cost between $365 and $553 in September.The cheapest round-trip price found within the last 5 days was $190 on Multiple Airlines (Sep 21-Sep 29).
How often are flights from Des Moines to San Francisco delayed?
About 33% of weekly flights between Des Moines and San Francisco have experienced delays in the past year, with the average delay time being 40 minutes.
What is the most punctual flight time for Des Moines to San Francisco flights?
Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What’s the top layover airport for flights from Des Moines to San Francisco?
Share of 1-stop round-trip flights from Des Moines to San Francisco chosen by Cheapflights users in the past 12 months, using the same layover each way.
Denver (DEN) – chosen by Cheapflights users on 75% of 1-stop itineraries from Des Moines to San Francisco on Cheapflights.
What’s the cheapest layover airport for flights from Des Moines to San Francisco?
Average round-trip fare for 1-stop flights from Des Moines to San Francisco, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Denver (DEN) is the most affordable 1-stop option, with an average round-trip price of $298.
What’s the fastest layover option from Des Moines to San Francisco?
Shortest average travel time for 1-stop one-way flights from Des Moines to San Francisco, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 5h 41m.
Which airport typically offers the quickest layover for flights from Des Moines to San Francisco?
Average layover duration for 1-stop one-way flights from Des Moines to San Francisco, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 1h 03m.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated August 3, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Entertainment
7.5
Boarding
8.1
Crew
8.6
Overall
8.0
Comfort
8.0
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
San Bruno
Fairfield
Emeryville
Roseville
Burlingame
Rancho Cordova
Vallejo
Cupertino
Newark
Hayward
San Ramon
Redwood City
San Carlos
Milpitas
Turlock
San Lorenzo
Davis
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Top 5 airlines flying from Des Moines to San Francisco
Discover the top 5 airlines that operate flights from Des Moines to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$120 | Average$295 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$253 | Average$499 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$274 | Average$532 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$346 | Average$466 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$349 | Average$490 | FlexibilityNo cancel fee | On-time63% |