$210+ Cheap flights from La Crosse to San Diego (LSE - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/7. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — SAN
May 28 — Jun 41
Round-trip
1 adult, Economy
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Find cheap flights from La Crosse to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from La Crosse to San Diego
Cheapest
Best
Last-minute
One-way
Cheapest flights from La Crosse to San DiegoExplore the most affordable flight options available from La Crosse to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.
Explore the most affordable flight options available from La Crosse to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:36 pm
LSE
- SAN
1 stop6h 57m
American Airlines
Sat 5/161:18 pm
SAN
- LSE
1 stop8h 36m
American Airlines
Deal found 4/23![American Airlines logo]()
$358
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:34 pm
LSE
- SAN
1 stop8h 05m
American Airlines
Tue 5/261:19 pm
SAN
- LSE
1 stop8h 47m
American Airlines
Deal found 4/23![American Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:36 pm
LSE
- SAN
1 stop6h 57m
American Airlines
Sun 5/1710:40 pm
SAN
- LSE
1 stop8h 44m
American Airlines
Deal found 4/27![American Airlines logo]()
$383
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:36 pm
LSE
- SAN
1 stop6h 57m
American Airlines
Sat 5/167:20 pm
SAN
- LSE
2 stops12h 04m
American Airlines
Deal found 4/23![American Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:53 pm
LSE
- SAN
1 stop7h 33m
American Airlines
Mon 8/310:28 pm
SAN
- LSE
2 stops10h 58m
American Airlines
Deal found 4/28![American Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/165:35 pm
LSE
- SAN
1 stop7h 53m
American Airlines
Mon 7/201:11 pm
SAN
- LSE
1 stop8h 48m
American Airlines
Deal found 4/25![American Airlines logo]()
$479
Best flights from La Crosse to San DiegoDiscover carefully curated flight deals from La Crosse to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 28, 2026.
Discover carefully curated flight deals from La Crosse to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 28, 2026.
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:36 pm
LSE
- SAN
1 stop6h 57m
American Airlines
Tue 5/193:09 pm
SAN
- LSE
1 stop6h 45m
American Airlines
Deal found 4/27![American Airlines logo]()
$383
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:36 pm
LSE
- SAN
1 stop6h 57m
American Airlines
Sun 5/1710:40 pm
SAN
- LSE
1 stop8h 44m
American Airlines
Deal found 4/26![American Airlines logo]()
$383
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/165:35 pm
LSE
- SAN
1 stop7h 53m
American Airlines
Mon 7/2010:28 pm
SAN
- LSE
2 stops10h 47m
American Airlines
Deal found 4/25![American Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:53 pm
LSE
- SAN
1 stop7h 33m
American Airlines
Mon 8/310:28 pm
SAN
- LSE
2 stops10h 58m
American Airlines
Deal found 4/28![American Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:53 pm
LSE
- SAN
1 stop7h 33m
American Airlines
Sun 8/27:15 pm
SAN
- LSE
2 stops14h 11m
American Airlines
Deal found 4/28![American Airlines logo]()
$481
Last-minute flights from La Crosse to San DiegoDiscover last-minute flight deals from La Crosse to San Diego. Data last updated April 28, 2026 and is based on user searches.
Discover last-minute flight deals from La Crosse to San Diego. Data last updated April 28, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:36 pm
LSE
- SAN
1 stop6h 57m
American Airlines
Sun 5/1710:40 pm
SAN
- LSE
1 stop8h 44m
American Airlines
Deal found 4/27![American Airlines logo]()
$383
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:36 pm
LSE
- SAN
1 stop6h 57m
American Airlines
Sat 5/167:20 pm
SAN
- LSE
2 stops12h 04m
American Airlines
Deal found 4/23![American Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:36 pm
LSE
- SAN
1 stop19h 52m
American Airlines
Wed 5/2010:40 pm
SAN
- LSE
1 stop16h 24m
American Airlines
Deal found 4/23![American Airlines logo]()
$510
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:36 pm
LSE
- SAN
1 stop6h 57m
American Airlines
Sat 5/161:18 pm
SAN
- LSE
1 stop8h 36m
American Airlines
Deal found 4/23![American Airlines logo]()
$358
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:34 pm
LSE
- SAN
1 stop8h 05m
American Airlines
Tue 5/261:19 pm
SAN
- LSE
1 stop8h 47m
American Airlines
Deal found 4/23![American Airlines logo]()
$379
One-way flights from La Crosse to San DiegoSearch for one-way flight options from La Crosse to San Diego. Find affordable one-way fares based on user searches. Data last updated April 28, 2026.
Search for one-way flight options from La Crosse to San Diego. Find affordable one-way fares based on user searches. Data last updated April 28, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:20 pm
LSE
- SAN
3 stops45h 13m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$210
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:11 pm
LSE
- SAN
1 stop16h 17m
United Airlines
Deal found 4/25![United Airlines logo]()
$371
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:32 pm
LSE
- SAN
1 stop8h 16m
American Airlines
Deal found 4/25![American Airlines logo]()
$387
Find flight deals from La Crosse to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from La Crosse (LSE) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $358 (American Airlines) |
One-way from | $210 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
Use the filters below to find and compare flights from La Crosse to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
La CrosseSan Diego
LSE - SAN
LSESAN
La Crosse
Thu 5/14
6:36 pm-11:33 pm
1 stop6h 57m
San Diego
Tue 5/19
3:09 pm-11:54 pm
1 stop6h 45m
$383
La CrosseSan Diego
LSE - SAN
LSESAN
La Crosse
Wed 5/13
6:36 pm-11:33 pm
1 stop6h 57m
San Diego
Sun 5/17
10:40 pm-9:24 am
1 stop8h 44m
$383
La CrosseSan Diego
LSE - SAN
LSESAN
La Crosse
Thu 7/16
5:35 pm-11:28 pm
1 stop7h 53m
San Diego
Mon 7/20
10:28 pm-11:15 am
2 stops10h 47m
$439
La CrosseSan Diego
LSE - SAN
LSESAN
La Crosse
Thu 7/30
5:53 pm-11:26 pm
1 stop7h 33m
San Diego
Mon 8/3
10:28 pm-11:26 am
2 stops10h 58m
$439
La CrosseSan Diego
LSE - SAN
LSESAN
La Crosse
Thu 7/30
5:53 pm-11:26 pm
1 stop7h 33m
San Diego
Sun 8/2
7:15 pm-11:26 am
2 stops14h 11m
$481
Cheapest one-way
La CrosseSan Diego
LSE - SAN
LSESAN
La Crosse
Sun 6/7
5:20 pm-12:33 pm
3 stops45h 13m
$210
La CrosseSan Diego
LSE - SAN
LSESAN
La Crosse
Mon 6/8
7:11 pm-9:28 am
1 stop16h 17m
$371
Quickest one-way
La CrosseSan Diego
LSE - SAN
LSESAN
La Crosse
Sun 6/7
5:32 pm-11:48 pm
1 stop8h 16m
$387
Sorted by cheapest first
Compare providers for flights from La Crosse to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from La Crosse to San Diego in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on La Crosse-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on La Crosse-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from La Crosse-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on La Crosse-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for La Crosse-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from La Crosse to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from La Crosse with our price prediction graph.
LSE-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated April 28, 2026.
Peruse reviews from past customers who have flown with American Airlines from La Crosse to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Overall
7.1
Boarding
7.5
Food
6.4
Entertainment
6.9
Comfort
7.2
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Crew
7.9
Overall
7.1
Boarding
7.5
Food
6.4
Entertainment
6.9
Comfort
7.2
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from La Crosse to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
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La Crosse and San Diego flights
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Top airline flying from La Crosse to San Diego
Discover the top airline that operate flights from La Crosse to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$358 | Average$554 | FlexibilityNo cancel fee | On-time71% |