$382+ Cheap flights from La Crosse to San Diego (LSE - SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — SAN
Oct 13 — Oct 201
Round-trip
1 adult, Economy
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Find cheap flights from La Crosse to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from La Crosse to San Diego
Cheapest
Best
Last-minute
One-way
Cheapest flights from La Crosse to San DiegoExplore the most affordable flight options available from La Crosse to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
Explore the most affordable flight options available from La Crosse to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/512:24 pm -
1 stop8h 51m
Thu 12/101:29 pm -
1 stop8h 49m
Deal found 9/9![American Airlines logo]()
$474
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:23 pm -
1 stop9h 05m
Tue 10/207:53 am -
1 stop8h 27m
Deal found 9/9![American Airlines logo]()
$480
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:04 am -
1 stop7h 30m
Sun 11/11:29 pm -
1 stop8h 49m
Deal found 9/12![American Airlines logo]()
$482
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2612:26 pm -
1 stop7h 03m
Tue 9/291:10 pm -
1 stop9h 10m
Deal found 9/8![American Airlines logo]()
$490
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:22 pm -
1 stop8h 03m
Wed 9/161:10 pm -
1 stop9h 10m
Deal found 9/12![American Airlines logo]()
$498
Best flights from La Crosse to San DiegoDiscover carefully curated flight deals from La Crosse to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
Discover carefully curated flight deals from La Crosse to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/712:17 pm -
1 stop9h 02m
Tue 1/1210:04 am -
1 stop7h 32m
Deal found 9/10![American Airlines logo]()
$474
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/512:24 pm -
1 stop8h 51m
Thu 12/101:29 pm -
1 stop8h 49m
Deal found 9/8![American Airlines logo]()
$474
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/35:57 am -
1 stop6h 59m
Sun 11/810:20 pm -
2 stops11h 33m
Deal found 9/10![American Airlines logo]()
$483
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2612:26 pm -
1 stop7h 03m
Tue 9/291:10 pm -
1 stop9h 10m
Deal found 9/8![American Airlines logo]()
$490
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:04 am -
2 stops10h 32m
Sun 11/19:25 pm -
2 stops12h 28m
Deal found 9/12![American Airlines logo]()
$492
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3012:23 pm -
2 stops11h 23m
Tue 11/31:05 pm -
2 stops9h 13m
Deal found 9/12![American Airlines logo]()
$492
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1812:49 pm -
1 stop6h 56m
Tue 12/223:33 pm -
1 stop6h 57m
Deal found 9/8![American Airlines logo]()
$494
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:00 am -
1 stop19h 36m
Tue 12/227:21 am -
1 stop15h 09m
Deal found 9/8![American Airlines logo]()
$524
Last-minute flights from La Crosse to San DiegoDiscover last-minute flight deals from La Crosse to San Diego. Data last updated September 13, 2026 and is based on user searches.
Discover last-minute flight deals from La Crosse to San Diego. Data last updated September 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:22 pm -
1 stop8h 03m
Wed 9/161:10 pm -
1 stop9h 10m
Deal found 9/12![American Airlines logo]()
$498
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2612:26 pm -
1 stop7h 03m
Tue 9/291:10 pm -
1 stop9h 10m
Deal found 9/8![American Airlines logo]()
$490
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:23 pm -
1 stop9h 05m
Tue 10/207:53 am -
1 stop8h 27m
Deal found 9/9![American Airlines logo]()
$480
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:04 am -
1 stop7h 30m
Sun 11/11:29 pm -
1 stop8h 49m
Deal found 9/12![American Airlines logo]()
$482
One-way flights from La Crosse to San DiegoSearch for one-way flight options from La Crosse to San Diego. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
Search for one-way flight options from La Crosse to San Diego. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:04 am -
1 stop16h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$382
Find flight deals from La Crosse to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from La Crosse (LSE) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $474 (American Airlines) |
One-way from | $382 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
Use the filters below to find and compare flights from La Crosse to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Mon 10/26
7:04 am-9:41 pm
1 stop16h 37m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$382
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Thu 1/7
12:17 pm-7:19 pm
1 stop9h 02m
San Diego
Tue 1/12
10:04 am-7:36 pm
1 stop7h 32m
$474
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Sat 12/5
12:24 pm-7:15 pm
1 stop8h 51m
San Diego
Thu 12/10
1:29 pm-12:18 am
1 stop8h 49m
$474
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Tue 11/3
5:57 am-10:56 am
1 stop6h 59m
San Diego
Sun 11/8
10:20 pm-11:53 am
2 stops11h 33m
$483
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Sat 9/26
12:26 pm-5:29 pm
1 stop7h 03m
San Diego
Tue 9/29
1:10 pm-12:20 am
1 stop9h 10m
$490
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Wed 10/28
7:04 am-3:36 pm
2 stops10h 32m
San Diego
Sun 11/1
9:25 pm-11:53 am
2 stops12h 28m
$492
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Fri 10/30
12:23 pm-9:46 pm
2 stops11h 23m
San Diego
Tue 11/3
1:05 pm-12:18 am
2 stops9h 13m
$492
Quickest round-trip
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Fri 12/18
12:49 pm-5:45 pm
1 stop6h 56m
San Diego
Tue 12/22
3:33 pm-12:30 am
1 stop6h 57m
$494
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Sat 12/19
6:00 am-11:36 pm
1 stop19h 36m
San Diego
Tue 12/22
7:21 am-12:30 am
1 stop15h 09m
$524
Sorted by cheapest first
Compare providers for flights from La Crosse to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from La Crosse to San Diego in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on La Crosse-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on La Crosse-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from La Crosse-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on La Crosse-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for La Crosse-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from La Crosse to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from La Crosse with our price prediction graph.
LSE-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated September 13, 2026.
Peruse reviews from past customers who have flown with American Airlines from La Crosse to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.2
Boarding
7.4
Crew
7.9
Entertainment
6.8
Overall
7.1
Food
6.4
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Comfort
7.2
Boarding
7.4
Crew
7.9
Entertainment
6.8
Overall
7.1
Food
6.4
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from La Crosse to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
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Coronado
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La Mesa
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Lemon Grove
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La Crosse and San Diego flights
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Top airline flying from La Crosse to San Diego
Discover the top airline that operate flights from La Crosse to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$358 | Average$528 | FlexibilityNo cancel fee | On-time71% |