$452+ Cheap flights from La Crosse to San Diego (LSE - SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/6. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — SAN
Nov 25 — Dec 21
Round-trip
1 adult, Economy
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Find cheap flights from La Crosse to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from La Crosse to San Diego
Cheapest
Best
Last-minute
Cheapest flights from La Crosse to San DiegoExplore the most affordable flight options available from La Crosse to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
Explore the most affordable flight options available from La Crosse to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:52 pm -
1 stop7h 07m
Thu 12/107:44 am -
1 stop8h 37m
Deal found 10/21![American Airlines logo]()
$497
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:01 pm -
1 stop16h 10m
Wed 11/46:25 am -
2 stops25h 06m
Deal found 10/22![Multiple Airlines logo]()
$513
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:52 pm -
1 stop7h 02m
Wed 11/117:41 am -
1 stop8h 35m
Deal found 10/22![American Airlines logo]()
$516
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/105:55 am -
1 stop6h 49m
Mon 12/147:44 am -
1 stop8h 37m
Deal found 10/25![American Airlines logo]()
$542
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:50 pm -
1 stop16h 44m
Mon 11/301:36 pm -
1 stop8h 44m
Deal found 10/26![American Airlines logo]()
$550
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:52 pm -
1 stop19h 47m
Mon 11/1610:40 pm -
1 stop11h 13m
Deal found 10/22![American Airlines logo]()
$560
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:57 am -
1 stop8h 42m
Tue 11/1011:08 am -
2 stops11h 10m
Deal found 10/22![American Airlines logo]()
$580
Best flights from La Crosse to San DiegoDiscover carefully curated flight deals from La Crosse to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
Discover carefully curated flight deals from La Crosse to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/65:40 am -
1 stop8h 33m
Sat 4/103:09 pm -
1 stop6h 45m
Deal found 10/26![American Airlines logo]()
$452
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:52 pm -
1 stop7h 07m
Thu 12/107:44 am -
1 stop8h 37m
Deal found 10/23![American Airlines logo]()
$497
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:52 pm -
1 stop7h 02m
Wed 11/117:41 am -
1 stop8h 35m
Deal found 10/25![American Airlines logo]()
$516
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/105:55 am -
1 stop6h 49m
Mon 12/147:44 am -
1 stop8h 37m
Deal found 10/25![American Airlines logo]()
$542
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:50 pm -
1 stop16h 44m
Mon 11/301:36 pm -
1 stop8h 44m
Deal found 10/26![American Airlines logo]()
$550
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:52 pm -
1 stop19h 47m
Mon 11/1610:40 pm -
1 stop11h 13m
Deal found 10/23![American Airlines logo]()
$560
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/275:34 am -
2 stops14h 50m
Sun 1/3110:13 am -
1 stop7h 44m
Deal found 10/22![American Airlines logo]()
$570
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:57 am -
1 stop6h 59m
Tue 11/101:29 pm -
1 stop8h 49m
Deal found 10/22![American Airlines logo]()
$570
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/275:34 am -
2 stops14h 50m
Sat 1/309:28 am -
2 stops12h 26m
Deal found 10/22![American Airlines logo]()
$597
Last-minute flights from La Crosse to San DiegoDiscover last-minute flight deals from La Crosse to San Diego. Data last updated October 26, 2026 and is based on user searches.
Discover last-minute flight deals from La Crosse to San Diego. Data last updated October 26, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:01 pm -
1 stop16h 10m
Wed 11/46:25 am -
2 stops25h 06m
Deal found 10/22![Multiple Airlines logo]()
$513
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:04 am -
1 stop7h 30m
Wed 11/47:41 am -
1 stop8h 35m
Deal found 10/22![American Airlines logo]()
$570
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/312:24 pm -
2 stops10h 11m
Tue 11/1012:28 pm -
2 stops9h 50m
Deal found 10/24![American Airlines logo]()
$591
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:57 am -
1 stop8h 42m
Tue 11/1011:08 am -
2 stops11h 10m
Deal found 10/22![American Airlines logo]()
$580
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:52 pm -
1 stop7h 02m
Wed 11/117:41 am -
1 stop8h 35m
Deal found 10/22![American Airlines logo]()
$516
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:52 pm -
1 stop19h 47m
Mon 11/1610:40 pm -
1 stop11h 13m
Deal found 10/22![American Airlines logo]()
$560
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:50 pm -
1 stop16h 44m
Mon 11/301:36 pm -
1 stop8h 44m
Deal found 10/26![American Airlines logo]()
$550
Find flight deals from La Crosse to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from La Crosse (LSE) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $331 (Kiwi.com) |
Popular in | October |
Cheapest in | April |
Average price | $879 |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
Use the filters below to find and compare flights from La Crosse to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Tue 4/6
5:40 am-12:13 pm
1 stop8h 33m
San Diego
Sat 4/10
3:09 pm-11:54 pm
1 stop6h 45m
$452
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Sat 12/5
6:52 pm-11:59 pm
1 stop7h 07m
San Diego
Thu 12/10
7:44 am-6:21 pm
1 stop8h 37m
$497
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Sat 11/7
6:52 pm-11:54 pm
1 stop7h 02m
San Diego
Wed 11/11
7:41 am-6:16 pm
1 stop8h 35m
$516
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Thu 12/10
5:55 am-10:44 am
1 stop6h 49m
San Diego
Mon 12/14
7:44 am-6:21 pm
1 stop8h 37m
$542
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Wed 11/25
6:50 pm-9:34 am
1 stop16h 44m
San Diego
Mon 11/30
1:36 pm-12:20 am
1 stop8h 44m
$550
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Fri 11/13
6:52 pm-12:39 pm
1 stop19h 47m
San Diego
Mon 11/16
10:40 pm-11:53 am
1 stop11h 13m
$560
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Wed 1/27
5:34 am-6:24 pm
2 stops14h 50m
San Diego
Sun 1/31
10:13 am-7:57 pm
1 stop7h 44m
$570
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Fri 11/6
5:57 am-10:56 am
1 stop6h 59m
San Diego
Tue 11/10
1:29 pm-12:18 am
1 stop8h 49m
$570
La CrosseSan Diego
LSE La Crosse - SAN San Diego
LSESAN
La Crosse
Wed 1/27
5:34 am-6:24 pm
2 stops14h 50m
San Diego
Sat 1/30
9:28 am-11:54 pm
2 stops12h 26m
$597
Sorted by cheapest first
Compare providers for flights from La Crosse to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from La Crosse to San Diego in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on La Crosse-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on La Crosse-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from La Crosse-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on La Crosse-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for La Crosse-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from La Crosse to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from La Crosse with our price prediction graph.
LSE-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated October 26, 2026.
Peruse reviews from past customers who have flown with American Airlines from La Crosse to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Crew
7.9
Comfort
7.1
Boarding
7.4
Food
6.4
Overall
7.0
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Entertainment
6.8
Crew
7.9
Comfort
7.1
Boarding
7.4
Food
6.4
Overall
7.0
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from La Crosse to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
San Ysidro
Poway
Coronado
La Mesa
Julian
Santee
Lemon Grove
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La Crosse and San Diego flights
Browse other La Crosse and San Diego flight options. Last updated on October 26, 2026.
Other flights from La Crosse
Browse through other flights departing from La Crosse. Flights are based on user searches made on Cheapflights and were last updated on October 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 26, 2026.
Top airline flying from La Crosse to San Diego
Discover the top airline that operate flights from La Crosse to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$358 | Average$528 | FlexibilityNo cancel fee | On-time71% |