How popular is this Des Moines to San Diego flight route?

Flights from Des Moines to San Diego have been viewed 1 times in the past calendar month.

How long is the flight from Des Moines to San Diego?

Departing from Des Moines to San Diego will take you 8h 36m. Airlines will cover a distance of 1425 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines flying from Des Moines to San Diego round-trip?

Cheapflights users have booked flights from Des Moines to San Diego round-trip from $104. Other airlines that can offer you cheap pricing are Frontier, from $125, and Delta, from $270. You may be able to fly from Des Moines to San Diego for 72% less than the average price by searching for these airlines.

In terms of precipitation, rainfall in San Diego ranges from 0.0 - 2.3 inches per month. February is typically the wettest month, when rainfall can reach 2.3 in. July is typically the driest time to visit San Diego when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Diego, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 57.2 F).

What are the most popular airlines that fly from Des Moines to San Diego?

Before booking your flight from Des Moines to San Diego check out the most popular airlines for this route: American Airlines, Southwest or United Airlines.

Most accurate provider : When it comes to deals on Des Moines-San Diego flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-San Diego flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-San Diego flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-San Diego flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to San Diego that include hotel bookings?

Yes. In addition to deals on Des Moines to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to San Diego?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to San Diego.

Can I find deals for business class flights from Des Moines to San Diego?

Yes. Cheapflights offers flight deals from Des Moines to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$104+ Flights from Des Moines to San Diego

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Des Moines to San Diego with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Des Moines to San Diego are usually found in June or August, booked 22 days in advance, depart on a Monday or Wednesday and return on a Friday

Cheap flight deals from Des Moines to San Diego

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$122 (Kiwi.com)
One-way from	$104 (Booking.com)
Popular in	March
Cheapest in	June
Average price	$359

Provider with most accurate pricing for Des Moines-San Diego flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-San Diego flights.

Search Deals

From Des Moines to San Diego

Search Deals

One-way flight from Des Moines to San Diego

Search Deals

Highest demand for flights based on searches. 16% potential increase in price ($71 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in October 2025

Search Deals

Find flight deals from Des Moines to San Diego

Cheapest flights from Des Moines to San Diego
Explore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2025.

Mon 12/87:58 pmDSM - SAN

1 stop6h 01mFrontier

Fri 12/126:34 amSAN - DSM

1 stop10h 29mFrontier

Deal found 10/25

$122

Fri 12/198:29 pmDSM - SAN

1 stop24h 46mMultiple Airlines

Tue 12/231:06 pmSAN - DSM

1 stop23h 04mMultiple Airlines

Deal found 10/26

$185

Thu 11/62:41 pmDSM - SAN

1 stop27h 19mFrontier

Wed 11/121:37 pmSAN - DSM

1 stop22h 19mFrontier

Deal found 10/26

$208

Sat 12/208:29 pmDSM - SAN

1 stop24h 46mFrontier

Sun 12/284:47 pmSAN - DSM

1 stop24h 57mFrontier

Deal found 10/25

$223

Sun 11/92:32 pmDSM - SAN

1 stop11h 18mFrontier

Thu 11/136:00 pmSAN - DSM

1 stop17h 49mFrontier

Deal found 10/25

$231

Mon 11/102:32 pmDSM - SAN

2 stops31h 52mMultiple Airlines

Thu 11/133:59 pmSAN - DSM

1 stop28h 41mMultiple Airlines

Deal found 10/26

$236

Wed 12/38:00 amDSM - SAN

1 stop11h 53mMultiple Airlines

Sun 12/72:02 pmSAN - DSM

2 stops27h 01mMultiple Airlines

Deal found 10/25

$238

Sun 11/92:17 pmDSM - SAN

1 stop24h 18mMultiple Airlines

Thu 11/133:59 pmSAN - DSM

1 stop28h 41mMultiple Airlines

Deal found 10/26

$245

Sun 11/92:17 pmDSM - SAN

1 stop24h 18mMultiple Airlines

Wed 11/126:41 amSAN - DSM

2 stops38h 22mMultiple Airlines

Deal found 10/26

$259

Best flights from Des Moines to San Diego
Discover carefully curated flight deals from Des Moines to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 27, 2025.

Sun 12/74:21 pmDSM - SAN

2 stops28h 54mMultiple Airlines

Sun 12/144:47 pmSAN - DSM

1 stop24h 16mMultiple Airlines

Deal found 10/25

$292

Mon 11/2411:28 amDSM - SAN

1 stop10h 45mDelta

Thu 11/276:30 amSAN - DSM

1 stop5h 38mDelta

Deal found 10/25

$293

Wed 12/105:21 amDSM - SAN

1 stop8h 36mAmerican Airlines

Wed 12/174:25 pmSAN - DSM

1 stop5h 34mAmerican Airlines

Deal found 10/26

$296

Thu 11/62:41 pmDSM - SAN

1 stop11h 09mFrontier

Mon 11/106:41 amSAN - DSM

1 stop5h 06mFrontier

Deal found 10/25

$305

Tue 12/98:20 amDSM - SAN

1 stop7h 55mSouthwest

Thu 12/117:10 amSAN - DSM

1 stop6h 25mSouthwest

Deal found 10/27

$320

Tue 12/91:31 pmDSM - SAN

2 stops8h 21mUnited Airlines

Thu 12/1111:02 amSAN - DSM

2 stops7h 46mUnited Airlines

Deal found 10/27

$330

Tue 12/92:59 pmDSM - SAN

1 stop7h 43mDelta

Tue 12/166:20 amSAN - DSM

1 stop8h 43mDelta

Deal found 10/25

$297

Tue 12/24:59 pmDSM - SAN

1 stop8h 45mDelta

Sat 12/136:20 amSAN - DSM

1 stop6h 06mDelta

Deal found 10/25

$297

Fri 11/72:32 pmDSM - SAN

1 stop11h 18mFrontier

Sun 11/96:41 amSAN - DSM

1 stop5h 06mFrontier

Deal found 10/27

$328

Thu 12/46:17 amDSM - SAN

1 stop9h 55mDelta

Sat 12/1310:30 pmSAN - DSM

1 stop10h 08mDelta

Deal found 10/26

$320

Last-minute flights from Des Moines to San Diego
Discover last-minute flight deals from Des Moines to San Diego. Data last updated October 27, 2025 and is based on user searches.

Thu 11/62:41 pmDSM - SAN

1 stop27h 19mFrontier

Wed 11/121:37 pmSAN - DSM

1 stop22h 19mFrontier

Deal found 10/26

$208

Sun 11/92:32 pmDSM - SAN

1 stop11h 18mFrontier

Thu 11/136:00 pmSAN - DSM

1 stop17h 49mFrontier

Deal found 10/25

$231

Sun 11/92:17 pmDSM - SAN

1 stop24h 18mMultiple Airlines

Thu 11/133:59 pmSAN - DSM

1 stop28h 41mMultiple Airlines

Deal found 10/26

$245

Sun 11/92:17 pmDSM - SAN

1 stop24h 18mMultiple Airlines

Wed 11/126:41 amSAN - DSM

2 stops38h 22mMultiple Airlines

Deal found 10/26

$259

Sun 11/92:17 pmDSM - SAN

1 stop24h 18mMultiple Airlines

Fri 11/148:30 amSAN - DSM

1 stop12h 10mMultiple Airlines

Deal found 10/26

$269

Mon 11/102:32 pmDSM - SAN

2 stops31h 52mMultiple Airlines

Thu 11/133:59 pmSAN - DSM

1 stop28h 41mMultiple Airlines

Deal found 10/26

$236

Mon 11/102:32 pmDSM - SAN

2 stops31h 52mMultiple Airlines

Fri 11/148:30 amSAN - DSM

1 stop12h 10mMultiple Airlines

Deal found 10/26

$260

Mon 11/102:32 pmDSM - SAN

1 stop11h 18mFrontier

Fri 11/146:41 amSAN - DSM

1 stop5h 08mFrontier

Deal found 10/26

$275

Mon 11/102:32 pmDSM - SAN

1 stop23h 35mFrontier

Wed 11/128:00 amSAN - DSM

2 stops27h 56mFrontier

Deal found 10/26

$281

One-way flights from Des Moines to San Diego
Search for one-way flight options from Des Moines to San Diego. Find affordable one-way fares based on user searches. Data last updated October 27, 2025.

Mon 11/32:32 pmDSM - SAN

1 stop23h 35mFrontier

Deal found 10/25

$104

Mon 12/298:29 pmDSM - SAN

1 stop29h 30mFrontier

Deal found 10/26

$112

Sat 11/1510:00 amDSM - SAN

1 stop12h 24mMultiple Airlines

Deal found 10/25

$118

Sat 11/158:02 amDSM - SAN

2 stops11h 26mUnited Airlines

Deal found 10/25

$154

Sat 12/208:29 pmDSM - SAN

1 stop5h 30mFrontier

Deal found 10/26

$171

Tue 12/95:01 pmDSM - SAN

1 stop8h 26mAlaska Airlines

Deal found 10/25

$189

Tue 12/98:00 amDSM - SAN

2 stops13h 52mUnited Airlines

Deal found 10/25

$194

Tue 12/302:35 pmDSM - SAN

1 stop6h 40mFrontier

Deal found 10/26

$211

Mon 11/31:43 pmDSM - SAN

3 stops32h 41mMultiple Airlines

Deal found 10/25

$239

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Sun 12/7

4:21 pm-7:15 pm

2 stops28h 54m

San Diego

Sun 12/14

4:47 pm-7:03 pm

1 stop24h 16m

$292

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Mon 11/24

11:28 am-8:13 pm

1 stop10h 45m

San Diego

Thu 11/27

6:30 am-2:08 pm

1 stop5h 38m

$293

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Wed 12/10

5:21 am-11:57 am

1 stop8h 36m

San Diego

Wed 12/17

4:25 pm-11:59 pm

1 stop5h 34m

$296

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 12/9

2:59 pm-8:42 pm

1 stop7h 43m

San Diego

Tue 12/16

6:20 am-5:03 pm

1 stop8h 43m

$297

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 12/2

4:59 pm-11:44 pm

1 stop8h 45m

San Diego

Sat 12/13

6:20 am-2:26 pm

1 stop6h 06m

$297

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Thu 11/6

2:41 pm-11:50 pm

1 stop11h 09m

San Diego

Mon 11/10

6:41 am-1:47 pm

1 stop5h 06m

$305

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 12/9

8:20 am-2:15 pm

1 stop7h 55m

San Diego

Thu 12/11

7:10 am-3:35 pm

1 stop6h 25m

$320

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Thu 12/4

6:17 am-2:12 pm

1 stop9h 55m

San Diego

Sat 12/13

10:30 pm-10:38 am

1 stop10h 08m

$320

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Fri 11/7

2:32 pm-11:50 pm

1 stop11h 18m

San Diego

Sun 11/9

6:41 am-1:47 pm

1 stop5h 06m

$328

Des MoinesSan Diego

DSM - SAN

DSMSAN

Des Moines

Tue 12/9

1:31 pm-7:52 pm

2 stops8h 21m

San Diego

Thu 12/11

11:02 am-8:48 pm

2 stops7h 46m

$330

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/25

Showing 1-10 of 18 results

Compare providers for flights from Des Moines to San Diego

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Diego in October.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Priceline	Price Accuracy1 star	Trust Score*3 stars
JustAirTicket	Price Accuracy-	Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-San Diego flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-San Diego flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-San Diego flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-San Diego flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to San Diego

How far ahead should I book a flight from Des Moines to San Diego?

The price you pay for your flight from Des Moines to San Diego may vary depending on when you book. For the best chance of a lower fare, look to book 22 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to San Diego?

Currently, August is the cheapest month in which you can book a flight from Des Moines to San Diego (average of $100). Flying from Des Moines to San Diego in December is currently the most expensive (average of $150). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SAN?

One of the essential ways to save on airfare from Des Moines to San Diego is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 60% on airfare.

What is the cheapest day to fly from Des Moines to San Diego?

Travelers seeking maximum savings on their Des Moines to San Diego flight should consider departing on Thursday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing San Diego

Read through reviews of airlines operating flights from Des Moines to San Diego, such as Southwest, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Southwest

8.0

Very good

4,238 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

United Airlines

7.4

Good

8,999 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

American Airlines

7.2

Good

11,031 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Allegiant Air

7.2

Good

695 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Frontier

5.8

Fair

3,123 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Related info for your journey

How popular is this Des Moines to San Diego flight route?
Flights from Des Moines to San Diego have been viewed 1 times in the past calendar month.
How long is the flight from Des Moines to San Diego?
Departing from Des Moines to San Diego will take you 8h 36m. Airlines will cover a distance of 1425 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines flying from Des Moines to San Diego round-trip?
Cheapflights users have booked flights from Des Moines to San Diego round-trip from $104. Other airlines that can offer you cheap pricing are Frontier, from $125, and Delta, from $270. You may be able to fly from Des Moines to San Diego for 72% less than the average price by searching for these airlines.
Can I find deals for flights from Des Moines to San Diego that include hotel bookings?
Yes. In addition to deals on Des Moines to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to San Diego?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to San Diego.
Can I find deals for business class flights from Des Moines to San Diego?
Yes. Cheapflights offers flight deals from Des Moines to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to San Diego?
Currently, August is the cheapest month in which you can book a flight from Des Moines to San Diego (average of $100). Flying from Des Moines to San Diego in December is currently the most expensive (average of $150). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Other flights to San Diego

Top 6 airlines flying from Des Moines to San Diego

Airline	Cheapest	Average	Flexibility	On-time
Allegiant Air	Cheapest$104	Average$170	FlexibilityNo cancel fee	On-time88%
Frontier	Cheapest$125	Average$228	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$270	Average$361	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$286	Average$444	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$286	Average$384	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$333	Average$485	FlexibilityNo cancel fee	On-time63%

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$104+ Cheap flights from Des Moines to San Diego (DSM - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/3. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to San Diego with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Des Moines to San Diego are usually found in June or August, booked 22 days in advance, depart on a Monday or Wednesday and return on a Friday

Cheap flight deals from Des Moines to San Diego

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to San Diego

Cheapest flights from Des Moines to San DiegoExplore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2025.

Explore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.

Compare providers for flights from Des Moines to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Diego in October.

Best time to book a flight from Des Moines to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to San Diego

How far ahead should I book a flight from Des Moines to San Diego?

What is the cheapest month to book a flight from Des Moines to San Diego?

What is the cheapest time of day to fly from DSM to SAN?

What is the cheapest day to fly from Des Moines to San Diego?

Reviews of airlines servicing San Diego

Read through reviews of airlines operating flights from Des Moines to San Diego, such as Southwest, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How popular is this Des Moines to San Diego flight route?

How long is the flight from Des Moines to San Diego?

What are the cheapest airlines flying from Des Moines to San Diego round-trip?

Can I find deals for flights from Des Moines to San Diego that include hotel bookings?

How can I find direct flights from Des Moines to San Diego?

Can I find deals for business class flights from Des Moines to San Diego?

What is the cheapest month to book a flight from Des Moines to San Diego?

Traveling to a place near San Diego?

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Top 6 airlines flying from Des Moines to San Diego

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Cheapest flights from Des Moines to San Diego
Explore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 27, 2025.