$95+ Cheap flights from Des Moines to San Diego (DSM - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAN
Apr 10 — Apr 171
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to San Diego are usually found in August or July, booked 36 days in advance, depart on a Monday or Wednesday and return on a Wednesday
Cheap flight deals from Des Moines to San Diego
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to San DiegoExplore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.
Explore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.
This Travelocity deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
- SAN
1 stop5h 36m
Frontier
Fri 5/86:25 am
SAN
- DSM
1 stop5h 04m
Frontier
Deal found 3/7![Frontier logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/410:00 am
DSM
- SAN
1 stop23h 21m
Multiple Airlines
Thu 4/1612:25 pm
SAN
- DSM
1 stop22h 44m
Multiple Airlines
Deal found 3/7![Multiple Airlines logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/182:20 pm
DSM
- SAN
1 stop11h 41m
Multiple Airlines
Tue 5/192:47 pm
SAN
- DSM
1 stop20h 12m
Multiple Airlines
Deal found 3/7![Multiple Airlines logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:04 pm
DSM
- SAN
1 stop11h 55m
Frontier
Mon 5/46:25 am
SAN
- DSM
1 stop11h 13m
Frontier
Deal found 3/10![Frontier logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/410:00 am
DSM
- SAN
1 stop23h 21m
Multiple Airlines
Wed 4/812:00 pm
SAN
- DSM
2 stops30h 13m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:01 pm
DSM
- SAN
1 stop22h 36m
Multiple Airlines
Fri 7/106:25 am
SAN
- DSM
1 stop11h 01m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$247
This Booking.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/108:14 pm
DSM
- SAN
1 stop5h 48m
Frontier
Sun 4/129:28 pm
SAN
- DSM
1 stop19h 46m
Frontier
Deal found 3/8![Frontier logo]()
$248
This Frontier deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/218:21 pm
DSM
- SAN
1 stop5h 47m
Frontier
Wed 3/256:25 am
SAN
- DSM
1 stop10h 51m
Frontier
Deal found 3/6![Frontier logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/182:20 pm
DSM
- SAN
1 stop11h 41m
Multiple Airlines
Thu 5/219:59 pm
SAN
- DSM
1 stop20h 53m
Multiple Airlines
Deal found 3/7![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/182:20 pm
DSM
- SAN
1 stop11h 41m
Multiple Airlines
Wed 5/202:47 pm
SAN
- DSM
1 stop27h 57m
Multiple Airlines
Deal found 3/7![Multiple Airlines logo]()
$257
This Frontier deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/258:21 pm
DSM
- SAN
1 stop5h 47m
Frontier
Mon 3/306:25 am
SAN
- DSM
1 stop10h 51m
Frontier
Deal found 3/6![Frontier logo]()
$260
This Travelocity deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/308:21 pm
DSM
- SAN
1 stop5h 47m
Frontier
Fri 4/36:25 am
SAN
- DSM
1 stop10h 49m
Frontier
Deal found 3/6![Frontier logo]()
$264
Best flights from Des Moines to San DiegoDiscover carefully curated flight deals from Des Moines to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 11, 2026.
Discover carefully curated flight deals from Des Moines to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 11, 2026.
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:30 pm
DSM
- SAN
1 stop5h 15m
Southwest
Wed 4/296:35 am
SAN
- DSM
1 stop5h 30m
Southwest
Deal found 3/8![Southwest logo]()
$317
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/211:40 pm
DSM
- SAN
1 stop5h 20m
United Airlines
Tue 8/256:40 am
SAN
- DSM
1 stop8h 22m
United Airlines
Deal found 3/6![United Airlines logo]()
$392
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:55 am
DSM
- SAN
2 stops7h 45m
Southwest
Wed 4/226:35 am
SAN
- DSM
1 stop5h 30m
Southwest
Deal found 3/10![Southwest logo]()
$322
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:55 am
DSM
- SAN
2 stops7h 45m
Southwest
Fri 4/172:35 pm
SAN
- DSM
1 stop5h 20m
Southwest
Deal found 3/10![Southwest logo]()
$377
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/25:00 am
DSM
- SAN
1 stop8h 21m
United Airlines
Sun 7/56:30 am
SAN
- DSM
1 stop7h 45m
United Airlines
Deal found 3/8![United Airlines logo]()
$427
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:21 pm
DSM
- SAN
1 stop9h 38m
United Airlines
Fri 4/177:14 pm
SAN
- DSM
1 stop19h 01m
United Airlines
Deal found 3/8![United Airlines logo]()
$478
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/251:30 pm
DSM
- SAN
1 stop6h 50m
Southwest
Fri 7/36:35 am
SAN
- DSM
1 stop7h 25m
Southwest
Deal found 3/8![Southwest logo]()
$457
This Southwest deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:25 pm
DSM
- SAN
2 stops6h 55m
Southwest
Tue 8/2511:10 am
SAN
- DSM
2 stops7h 50m
Southwest
Deal found 3/6![Southwest logo]()
$457
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/41:45 pm
DSM
- SAN
2 stops7h 15m
Southwest
Fri 5/812:30 pm
SAN
- DSM
2 stops7h 25m
Southwest
Deal found 3/7![Southwest logo]()
$467
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/136:10 am
DSM
- SAN
2 stops7h 20m
Southwest
Wed 6/177:50 am
SAN
- DSM
2 stops8h 30m
Southwest
Deal found 3/10![Southwest logo]()
$477
Last-minute flights from Des Moines to San DiegoDiscover last-minute flight deals from Des Moines to San Diego. Data last updated March 11, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Diego. Data last updated March 11, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/188:21 pm
DSM
- SAN
1 stop5h 47m
Frontier
Mon 3/236:25 am
SAN
- DSM
1 stop10h 51m
Frontier
Deal found 3/7![Frontier logo]()
$291
This Frontier deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/218:21 pm
DSM
- SAN
1 stop5h 47m
Frontier
Wed 3/256:25 am
SAN
- DSM
1 stop10h 51m
Frontier
Deal found 3/6![Frontier logo]()
$251
This Frontier deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/258:21 pm
DSM
- SAN
1 stop5h 47m
Frontier
Mon 3/306:25 am
SAN
- DSM
1 stop10h 51m
Frontier
Deal found 3/6![Frontier logo]()
$260
This Travelocity deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/308:21 pm
DSM
- SAN
1 stop5h 47m
Frontier
Fri 4/36:25 am
SAN
- DSM
1 stop10h 49m
Frontier
Deal found 3/6![Frontier logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/410:00 am
DSM
- SAN
1 stop23h 21m
Multiple Airlines
Thu 4/1612:25 pm
SAN
- DSM
1 stop22h 44m
Multiple Airlines
Deal found 3/7![Multiple Airlines logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/410:00 am
DSM
- SAN
1 stop23h 21m
Multiple Airlines
Wed 4/812:00 pm
SAN
- DSM
2 stops30h 13m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/410:00 am
DSM
- SAN
1 stop23h 21m
Multiple Airlines
Mon 4/67:51 am
SAN
- DSM
2 stops9h 23m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$274
This Booking.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/108:14 pm
DSM
- SAN
1 stop5h 48m
Frontier
Sun 4/129:28 pm
SAN
- DSM
1 stop19h 46m
Frontier
Deal found 3/8![Frontier logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:04 pm
DSM
- SAN
1 stop11h 55m
Frontier
Mon 5/46:25 am
SAN
- DSM
1 stop11h 13m
Frontier
Deal found 3/10![Frontier logo]()
$236
One-way flights from Des Moines to San DiegoSearch for one-way flight options from Des Moines to San Diego. Find affordable one-way fares based on user searches. Data last updated March 11, 2026.
Search for one-way flight options from Des Moines to San Diego. Find affordable one-way fares based on user searches. Data last updated March 11, 2026.
This Frontier deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/108:14 pm
DSM
- SAN
1 stop5h 48m
Frontier
Deal found 3/9![Frontier logo]()
$95
This Flightnetwork deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:04 pm
DSM
- SAN
1 stop11h 55m
Frontier
Deal found 3/6![Frontier logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/69:45 pm
DSM
- SAN
2 stops42h 19m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$114
This Frontier deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/188:21 pm
DSM
- SAN
1 stop5h 47m
Frontier
Deal found 3/9![Frontier logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:56 pm
DSM
- SAN
1 stop21h 12m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$117
This Frontier deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:14 pm
DSM
- SAN
1 stop5h 48m
Frontier
Deal found 3/9![Frontier logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1211:00 am
DSM
- SAN
2 stops50h 34m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$131
This Priceline deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:21 pm
DSM
- SAN
1 stop5h 47m
Frontier
Deal found 3/9![Frontier logo]()
$135
This Booking.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/208:21 pm
DSM
- SAN
1 stop26h 12m
Frontier
Deal found 3/6![Frontier logo]()
$141
This Priceline deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:21 pm
DSM
- SAN
1 stop5h 34m
Frontier
Deal found 3/9![Frontier logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/38:21 pm
DSM
- SAN
2 stops24h 16m
Frontier
Deal found 3/9![Frontier logo]()
$154
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/222:02 pm
DSM
- SAN
1 stop8h 48m
American Airlines
Deal found 3/7![American Airlines logo]()
$159
Find flight deals from Des Moines to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $211 (Travelocity) |
One-way from | $95 (Frontier) |
Popular in | March |
Cheapest in | August |
Average price | $510 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Wed 4/22
6:30 pm-9:45 pm
1 stop5h 15m
San Diego
Wed 4/29
6:35 am-2:05 pm
1 stop5h 30m
$317
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Wed 4/15
6:55 am-12:40 pm
2 stops7h 45m
San Diego
Wed 4/22
6:35 am-2:05 pm
1 stop5h 30m
$322
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Wed 4/15
6:55 am-12:40 pm
2 stops7h 45m
San Diego
Fri 4/17
2:35 pm-9:55 pm
1 stop5h 20m
$377
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Fri 8/21
1:40 pm-5:00 pm
1 stop5h 20m
San Diego
Tue 8/25
6:40 am-5:02 pm
1 stop8h 22m
$392
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Thu 7/2
5:00 am-11:21 am
1 stop8h 21m
San Diego
Sun 7/5
6:30 am-4:15 pm
1 stop7h 45m
$427
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Thu 6/25
1:30 pm-6:20 pm
1 stop6h 50m
San Diego
Fri 7/3
6:35 am-4:00 pm
1 stop7h 25m
$457
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Fri 8/21
2:25 pm-7:20 pm
2 stops6h 55m
San Diego
Tue 8/25
11:10 am-9:00 pm
2 stops7h 50m
$457
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Mon 5/4
1:45 pm-7:00 pm
2 stops7h 15m
San Diego
Fri 5/8
12:30 pm-9:55 pm
2 stops7h 25m
$467
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Sat 6/13
6:10 am-11:30 am
2 stops7h 20m
San Diego
Wed 6/17
7:50 am-6:20 pm
2 stops8h 30m
$477
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Mon 4/13
3:21 pm-10:59 pm
1 stop9h 38m
San Diego
Fri 4/17
7:14 pm-4:15 pm
1 stop19h 01m
$478
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Diego in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Des Moines with our price prediction graph.
DSM-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Diego
How far ahead should I book a flight from Des Moines to San Diego?
Use this chart to determine the optimal time to book a round-trip flight from Des Moines to San Diego. Price data was last updated on March 6, 2026.
The price you pay for your flight from Des Moines to San Diego may vary depending on when you book. For the best chance of a lower fare, look to book 36 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to San Diego?
Currently, May is the cheapest month in which you can book a flight from Des Moines to San Diego (average of $95). Flying from Des Moines to San Diego in March is currently the most expensive (average of $157). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated March 11, 2026.
Read through reviews of airlines operating flights from Des Moines to San Diego, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentWalter,Aug 2025
OAK - SAN
Overall
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentWalter,Aug 2025
OAK - SAN
Overall
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentWalter,Aug 2025
OAK - SAN
Overall
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentWalter,Aug 2025
OAK - SAN
Overall
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentWalter,Aug 2025
OAK - SAN
Overall
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentWalter,Aug 2025
OAK - SAN
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove
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Des Moines and San Diego flights
Browse other Des Moines and San Diego flight options. Last updated on March 11, 2026.
Other flights from Des Moines
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Top 6 airlines flying from Des Moines to San Diego
Discover the top 6 airlines that operate flights from Des Moines to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$100 | Average$238 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$101 | Average$166 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$118 | Average$336 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$282 | Average$422 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$286 | Average$369 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$303 | Average$472 | FlexibilityNo cancel fee | On-time63% |