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$99+ Cheap flights from Des Moines (DSM) to North Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CLT
May 28 — Jun 41
Thu 5/28
Thu 6/4
1 adult, Economy
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Cheap flight deals from Des Moines to North Carolina

Cheapest flights from Des Moines to North Carolina
Explore the most affordable flight options available from Des Moines to North Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:00 am
DSM
-
TYS
1 stop6h 03m
Allegiant Air
Thu 5/211:03 pm
TYS
-
DSM
1 stop10h 28m
Allegiant Air
Deal found 4/23$216
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
-
RDU
1 stop20h 15m
Multiple Airlines
Fri 5/2911:47 am
RDU
-
DSM
1 stop12h 37m
Multiple Airlines
Deal found 4/26$219
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
-
RDU
1 stop20h 15m
Multiple Airlines
Thu 6/412:54 pm
RDU
-
DSM
2 stops11h 04m
Multiple Airlines
Deal found 4/26$222
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:45 am
DSM
-
RDU
1 stop26h 07m
Multiple Airlines
Wed 5/138:59 am
RDU
-
DSM
1 stop29h 47m
Multiple Airlines
Deal found 4/26$223
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:45 am
DSM
-
TYS
1 stop12h 05m
Allegiant Air
Thu 5/211:03 pm
TYS
-
DSM
1 stop10h 28m
Allegiant Air
Deal found 4/23$225
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:41 pm
DSM
-
TYS
1 stop4h 20m
Delta
Thu 6/45:40 am
TYS
-
DSM
1 stop6h 28m
Delta
Deal found 4/23$226
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/113:37 pm
DSM
-
CLT
1 stop25h 01m
Multiple Airlines
Thu 6/181:09 pm
CLT
-
DSM
1 stop9h 38m
Multiple Airlines
Deal found 4/26$230
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/84:07 pm
DSM
-
CLT
1 stop21h 04m
Multiple Airlines
Thu 6/119:37 am
CLT
-
DSM
1 stop12h 50m
Multiple Airlines
Deal found 4/23$231
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
-
RDU
1 stop20h 15m
Multiple Airlines
Wed 6/312:33 pm
RDU
-
DSM
2 stops26h 45m
Multiple Airlines
Deal found 4/27$237
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
-
RDU
1 stop20h 15m
Multiple Airlines
Mon 6/16:15 am
RDU
-
DSM
2 stops18h 09m
Multiple Airlines
Deal found 4/26$238
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
-
CLT
2 stops24h 44m
Multiple Airlines
Mon 6/112:29 pm
CLT
-
DSM
1 stop11h 55m
Multiple Airlines
Deal found 4/23$238
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:08 pm
DSM
-
TYS
1 stop27h 52m
Allegiant Air
Mon 7/137:20 pm
TYS
-
DSM
1 stop21h 04m
Allegiant Air
Deal found 4/23$240

Find flight deals from Des Moines to North Carolina

Keep the following information in mind while searching for Des Moines to North Carolina flight deals. Data was last updated April 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$216
(Kiwi.com)

One-way from

$99
(Trip.com)

Popular in

April

Cheapest in

September

Average price

$436

Good round-trip deal

$427 or less

Good one-way deal

$214 or less
Provider with most accurate pricing for Des Moines-Raleigh-Durham flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Raleigh-Durham flights.
Search Deals
From Des Moines to North Carolina
Search Deals
One-way flight from Des Moines to North Carolina
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($26 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals
Price to beat on a round-trip flight from Des Moines to North Carolina.
Search Deals
Price to beat on a one-way flight from Des Moines to North Carolina.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to North Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
Use the filters below to find and compare flights from Des Moines to North Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 5/27

5:27 am-11:09 am

1 stop4h 42m

Knoxville McGhee Tyson

Thu 6/4

1:59 pm-5:53 pm

1 stop4h 54m

$226

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 5/27

6:00 am-2:27 pm

2 stops7h 27m

Knoxville McGhee Tyson

Thu 6/4

6:30 am-10:27 am

1 stop4h 57m

$260

Des MoinesAsheville

DSM - AVL

DSMAVL

Des Moines

Mon 5/18

2:03 pm-11:15 pm

1 stop8h 12m

Asheville Regional

Fri 5/22

12:40 pm-11:24 pm

1 stop11h 44m

$292

Des MoinesAsheville

DSM - AVL

DSMAVL

Des Moines

Mon 5/18

2:03 pm-11:15 pm

1 stop8h 12m

Asheville Regional

Thu 5/21

6:30 am-10:31 pm

2 stops17h 01m

$301

Des MoinesGreensboro

DSM - GSO

DSMGSO

Des Moines

Wed 5/27

1:37 pm-7:08 pm

1 stop4h 31m

Greensboro/H. Point

Sat 5/30

8:08 pm-12:17 am

1 stop5h 09m

$311

Des MoinesGreensboro

DSM - GSO

DSMGSO

Des Moines

Wed 6/24

6:39 pm-11:59 pm

1 stop4h 20m

Greensboro/H. Point

Tue 6/30

9:30 am-3:57 pm

1 stop7h 27m

$311

Des MoinesGreensboro

DSM - GSO

DSMGSO

Des Moines

Tue 6/23

1:37 pm-7:08 pm

1 stop4h 31m

Greensboro/H. Point

Tue 6/30

7:48 pm-12:10 am

1 stop5h 22m

$311

Des MoinesGreensboro

DSM - GSO

DSMGSO

Des Moines

Tue 6/23

11:28 am-7:11 pm

1 stop6h 43m

Greensboro/H. Point

Tue 6/30

5:25 am-10:57 am

1 stop6h 32m

$311

Des MoinesWilmington

DSM - ILM

DSMILM

Des Moines

Sat 6/6

1:37 pm-7:23 pm

1 stop4h 46m

Wilmington New Hanover County

Wed 6/17

1:07 pm-8:43 pm

1 stop8h 36m

$311

Des MoinesWilmington

DSM - ILM

DSMILM

Des Moines

Sat 9/5

6:11 pm-11:58 pm

1 stop4h 47m

Wilmington New Hanover County

Sat 9/12

5:00 pm-11:07 pm

1 stop7h 07m

$311

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/23

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Des Moines to North Carolina

Have a flexible travel schedule? Discover the best time to fly to North Carolina from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to North Carolina

How far ahead should I book a flight from Des Moines to North Carolina?

The best time to book flights from Des Moines to North Carolina is 39 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Des Moines to North Carolina?

Currently, March is the cheapest month in which you can book a flight from Des Moines to North Carolina (average of $155). Flying from Des Moines to North Carolina in December is currently the most expensive (average of $309). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to NC?

Find hourly flight availability from Des Moines to North Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 28, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to North Carolina as you normally would.

How much does it cost to fly round-trip from Des Moines to North Carolina?

Reviews of airlines servicing North Carolina

Get insights into the airlines that provide service to North Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to North Carolina. Reviews last updated April 28, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to North Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,314 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,314 reviews
Southwest
8.0
Very good
4,314 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Delta
7.9
Good
8,467 reviews
Southwest
8.0
Very good
4,314 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
United Airlines
7.4
Good
9,672 reviews
Southwest
8.0
Very good
4,314 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,677 reviews
Southwest
8.0
Very good
4,314 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to North Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to North Carolina?

    Most people fly from Des Moines (DSM) if they book a flight from Des Moines to North Carolina. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.

  • How popular is this Des Moines to North Carolina flight route?

    The Des Moines to North Carolina flight path was viewed by 7 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Des Moines to North Carolina?

    Departing from Des Moines to North Carolina will take you 4h 42m. Airlines will cover a distance of 654 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Des Moines to North Carolina one-way?

    The cheapest airline one-way is Southwest, with whom users have recently found tickets for as low as $135. However, be on the lookout for offers from United Airlines and American Airlines, as they are both options that can get you from Des Moines to North Carolina for a low price.

  • What are the most popular routes from Des Moines to North Carolina?

    Most travelers choose Des Moines - Charlotte Douglas, Des Moines - Myrtle Beach Intl or Des Moines - Raleigh-Durham when deciding on the best route from Des Moines to North Carolina.

  • What are the cheapest flights from Des Moines to North Carolina?

    On average you can expect to pay $404 for a flight from Des Moines to North Carolina. The cheapest flight overall is $131 while the most popular route, (Des Moines - Charlotte Douglas) is currently priced at $230.

  • Can I find deals for flights from Des Moines to North Carolina that include hotel bookings?

    Yes. In addition to deals on Des Moines to North Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to North Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to North Carolina.

  • Can I find deals for business class flights from Des Moines to North Carolina?

    Yes. Cheapflights offers flight deals from Des Moines to North Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to North Carolina?

    Currently, March is the cheapest month in which you can book a flight from Des Moines to North Carolina (average of $155). Flying from Des Moines to North Carolina in December is currently the most expensive (average of $309). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Des Moines to North Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Moline to LaGuardia flights
Omaha to Boston flights
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Des Moines to Baltimore flights
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Des Moines to Atlanta flights

Top 4 airlines flying from Des Moines to North Carolina

Discover the top 4 airlines that operate flights from Des Moines to North Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$216Average$423FlexibilityNo cancel feeOn-time63%
DeltaCheapest$236Average$388FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$236Average$366FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$268Average$390FlexibilityNo cancel feeOn-time69%

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