$86+ Cheap flights from Des Moines (DSM) to North Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — RDU
Apr 7 — Apr 141
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to North CarolinaExplore the most affordable flight options available from Des Moines to North Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 8, 2026.
Explore the most affordable flight options available from Des Moines to North Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 8, 2026.
This CheapOair deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:20 pm
DSM
- CLT
1 stop25h 32m
Frontier
Sun 5/107:49 pm
CLT
- DSM
1 stop18h 40m
Frontier
Deal found 3/6![Frontier logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2310:20 am
DSM
- RDU
1 stop21h 17m
Frontier
Wed 3/256:50 am
RDU
- DSM
2 stops13h 26m
Frontier
Deal found 3/6![Frontier logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/247:30 am
DSM
- MYR
1 stop26h 27m
Multiple Airlines
Fri 5/2911:52 am
MYR
- DSM
1 stop12h 32m
Multiple Airlines
Deal found 3/4![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CLT
1 stop15h 05m
Multiple Airlines
Mon 6/19:11 am
CLT
- DSM
1 stop15h 13m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:56 pm
DSM
- AVL
1 stop27h 35m
Multiple Airlines
Wed 3/253:25 pm
AVL
- DSM
1 stop23h 04m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/57:00 am
DSM
- MYR
1 stop12h 48m
Multiple Airlines
Wed 4/83:29 pm
MYR
- DSM
1 stop23h 17m
Multiple Airlines
Deal found 3/4![Multiple Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/192:59 pm
DSM
- RDU
2 stops47h 05m
Multiple Airlines
Sun 4/269:49 pm
RDU
- DSM
1 stop16h 20m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/37:00 am
DSM
- RDU
1 stop6h 43m
Multiple Airlines
Wed 5/134:07 pm
RDU
- DSM
2 stops24h 08m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:00 am
DSM
- AVL
1 stop15h 23m
Multiple Airlines
Wed 3/253:25 pm
AVL
- DSM
2 stops30h 18m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/182:03 pm
DSM
- TYS
1 stop23h 55m
Allegiant Air
Sun 5/243:46 pm
TYS
- DSM
1 stop7h 45m
Allegiant Air
Deal found 3/6![Allegiant Air logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/43:37 pm
DSM
- RDU
2 stops29h 16m
Multiple Airlines
Thu 6/118:30 am
RDU
- DSM
1 stop6h 48m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:00 am
DSM
- AVL
1 stop15h 23m
Allegiant Air
Wed 3/253:25 pm
AVL
- DSM
1 stop23h 04m
Allegiant Air
Deal found 3/8![Allegiant Air logo]()
$265
Best flights from Des Moines to North CarolinaDiscover carefully curated flight deals from Des Moines to North Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 8, 2026.
Discover carefully curated flight deals from Des Moines to North Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:00 am
DSM
- AVL
1 stop15h 23m
Multiple Airlines
Wed 3/253:25 pm
AVL
- DSM
2 stops30h 18m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$264
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:35 am
DSM
- TYS
1 stop4h 42m
Delta
Tue 4/75:40 am
TYS
- DSM
1 stop6h 08m
Delta
Deal found 3/5![Delta logo]()
$271
This United Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/252:59 pm
DSM
- TYS
1 stop7h 45m
United Airlines
Sat 3/287:00 am
TYS
- DSM
1 stop4h 28m
United Airlines
Deal found 3/3![United Airlines logo]()
$281
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:35 am
DSM
- RDU
1 stop4h 05m
Southwest
Tue 5/126:10 am
RDU
- DSM
2 stops8h 55m
Southwest
Deal found 3/4![Southwest logo]()
$284
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:09 am
DSM
- GSO
1 stop7h 36m
American Airlines
Sun 5/38:17 pm
GSO
- DSM
1 stop4h 32m
American Airlines
Deal found 3/3![American Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:45 am
DSM
- TYS
1 stop27h 40m
Allegiant Air
Fri 5/156:20 pm
TYS
- DSM
1 stop24h 20m
Allegiant Air
Deal found 3/3![Allegiant Air logo]()
$431
This Delta deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:44 pm
DSM
- RDU
1 stop5h 13m
Delta
Tue 5/126:00 am
RDU
- DSM
1 stop5h 16m
Delta
Deal found 3/6![Delta logo]()
$287
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:20 am
DSM
- GSO
1 stop4h 33m
United Airlines
Thu 4/96:15 am
GSO
- DSM
1 stop7h 14m
United Airlines
Deal found 3/5![United Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1911:09 am
DSM
- AVL
1 stop6h 21m
American Airlines
Sun 4/266:00 am
AVL
- DSM
1 stop5h 26m
American Airlines
Deal found 3/5![American Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/237:51 pm
DSM
- AVL
1 stop18h 37m
Multiple Airlines
Fri 3/276:00 am
AVL
- DSM
1 stop14h 16m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$310
This Delta deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:51 am
DSM
- RDU
1 stop4h 13m
Delta
Sat 5/166:28 am
RDU
- DSM
1 stop5h 40m
Delta
Deal found 3/6![Delta logo]()
$287
This United Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:20 am
DSM
- GSO
1 stop4h 33m
United Airlines
Sun 4/126:15 am
GSO
- DSM
1 stop5h 29m
United Airlines
Deal found 3/3![United Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/222:02 pm
DSM
- ILM
1 stop6h 53m
American Airlines
Wed 4/296:16 pm
ILM
- DSM
1 stop5h 02m
American Airlines
Deal found 3/7![American Airlines logo]()
$292
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/84:20 pm
DSM
- RDU
1 stop4h 25m
Southwest
Tue 5/125:40 am
RDU
- DSM
1 stop9h 25m
Southwest
Deal found 3/4![Southwest logo]()
$329
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/142:44 pm
DSM
- AVL
1 stop6h 49m
Delta
Sat 4/185:43 am
AVL
- DSM
1 stop6h 22m
Delta
Deal found 3/4![Delta logo]()
$289
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:00 am
DSM
- AVL
2 stops8h 03m
American Airlines
Sat 4/186:00 am
AVL
- DSM
1 stop5h 26m
American Airlines
Deal found 3/6![American Airlines logo]()
$294
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:40 am
DSM
- MYR
2 stops10h 35m
Southwest
Wed 4/224:05 pm
MYR
- DSM
2 stops7h 05m
Southwest
Deal found 3/5![Southwest logo]()
$336
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:14 pm
DSM
- CLT
1 stop21h 40m
Multiple Airlines
Mon 4/206:40 am
CLT
- DSM
2 stops17h 17m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:44 pm
DSM
- AVL
1 stop6h 49m
Delta
Wed 5/65:43 am
AVL
- DSM
1 stop6h 22m
Delta
Deal found 3/6![Delta logo]()
$289
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:16 pm
DSM
- TYS
1 stop5h 02m
American Airlines
Tue 5/55:00 am
TYS
- DSM
2 stops7h 30m
American Airlines
Deal found 3/3![American Airlines logo]()
$296
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:05 pm
DSM
- ORF
1 stop4h 54m
United Airlines
Sat 5/166:00 am
ORF
- DSM
1 stop5h 37m
United Airlines
Deal found 3/6![United Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:15 pm
DSM
- ORF
1 stop4h 55m
Southwest
Tue 4/284:25 pm
ORF
- DSM
2 stops6h 45m
Southwest
Deal found 3/7![Southwest logo]()
$342
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/24:23 pm
DSM
- TYS
1 stop5h 36m
Delta
Tue 5/512:30 pm
TYS
- DSM
1 stop7h 58m
Delta
Deal found 3/4![Delta logo]()
$291
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:00 pm
DSM
- RDU
1 stop6h 50m
United Airlines
Fri 5/297:59 pm
RDU
- DSM
1 stop5h 34m
United Airlines
Deal found 3/6![United Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:15 pm
DSM
- CLT
1 stop4h 40m
Southwest
Tue 4/286:40 am
CLT
- DSM
2 stops8h 25m
Southwest
Deal found 3/7![Southwest logo]()
$346
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:00 am
DSM
- ILM
1 stop6h 48m
American Airlines
Sat 5/24:50 pm
ILM
- DSM
1 stop8h 09m
American Airlines
Deal found 3/3![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/33:21 pm
DSM
- TYS
1 stop6h 13m
United Airlines
Fri 4/107:00 am
TYS
- DSM
1 stop6h 29m
United Airlines
Deal found 3/6![United Airlines logo]()
$343
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:30 am
DSM
- ORF
2 stops10h 00m
Southwest
Mon 4/275:25 pm
ORF
- DSM
2 stops6h 40m
Southwest
Deal found 3/4![Southwest logo]()
$347
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:00 am
DSM
- ILM
2 stops7h 13m
American Airlines
Tue 5/126:00 am
ILM
- DSM
1 stop5h 26m
American Airlines
Deal found 3/3![American Airlines logo]()
$330
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/305:20 pm
DSM
- MYR
1 stop5h 44m
Delta
Tue 3/316:00 am
MYR
- DSM
1 stop5h 48m
Delta
Deal found 3/7![Delta logo]()
$335
Last-minute flights from Des Moines to North CarolinaDiscover last-minute flight deals from Des Moines to North Carolina. Data last updated March 8, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to North Carolina. Data last updated March 8, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:56 pm
DSM
- AVL
1 stop27h 35m
Multiple Airlines
Wed 3/253:25 pm
AVL
- DSM
1 stop23h 04m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:00 am
DSM
- AVL
1 stop15h 23m
Multiple Airlines
Wed 3/253:25 pm
AVL
- DSM
2 stops30h 18m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:00 am
DSM
- AVL
1 stop15h 23m
Allegiant Air
Wed 3/253:25 pm
AVL
- DSM
1 stop23h 04m
Allegiant Air
Deal found 3/8![Allegiant Air logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2310:20 am
DSM
- RDU
1 stop21h 17m
Frontier
Wed 3/256:50 am
RDU
- DSM
2 stops13h 26m
Frontier
Deal found 3/6![Frontier logo]()
$236
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/13:21 pm
DSM
- TYS
1 stop6h 47m
United Airlines
Tue 4/74:30 pm
TYS
- DSM
1 stop8h 12m
United Airlines
Deal found 3/5![United Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/37:40 pm
DSM
- TYS
1 stop17h 29m
Allegiant Air
Sun 4/57:30 am
TYS
- DSM
1 stop7h 16m
Allegiant Air
Deal found 3/7![Allegiant Air logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/57:00 am
DSM
- MYR
1 stop12h 48m
Multiple Airlines
Wed 4/83:29 pm
MYR
- DSM
1 stop23h 17m
Multiple Airlines
Deal found 3/4![Multiple Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:48 pm
DSM
- CLT
2 stops26h 29m
Multiple Airlines
Thu 4/99:25 am
CLT
- DSM
1 stop13h 41m
Multiple Airlines
Deal found 3/4![Multiple Airlines logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/192:59 pm
DSM
- RDU
2 stops47h 05m
Multiple Airlines
Sun 4/269:49 pm
RDU
- DSM
1 stop16h 20m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$252
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/218:04 am
DSM
- RDU
1 stop4h 54m
United Airlines
Wed 4/293:00 pm
RDU
- DSM
1 stop7h 32m
United Airlines
Deal found 3/5![United Airlines logo]()
$271
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/222:02 pm
DSM
- RDU
1 stop6h 53m
American Airlines
Mon 4/276:00 pm
RDU
- DSM
1 stop6h 49m
American Airlines
Deal found 3/5![American Airlines logo]()
$277
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:04 pm
DSM
- RDU
1 stop30h 00m
Multiple Airlines
Wed 4/294:00 pm
RDU
- DSM
2 stops31h 06m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$278
One-way flights from Des Moines to North CarolinaSearch for one-way flight options from Des Moines to North Carolina. Find affordable one-way fares based on user searches. Data last updated March 8, 2026.
Search for one-way flight options from Des Moines to North Carolina. Find affordable one-way fares based on user searches. Data last updated March 8, 2026.
This Expedia deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/258:21 pm
DSM
- RDU
1 stop20h 27m
Frontier
Deal found 3/3![Frontier logo]()
$86
This Trip.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
- RDU
1 stop19h 42m
Frontier
Deal found 3/6![Frontier logo]()
$89
This CheapOair deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
- CLT
1 stop21h 31m
Frontier
Deal found 3/4![Frontier logo]()
$92
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:00 am
DSM
- RDU
1 stop7h 08m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/1611:00 am
DSM
- CLT
1 stop20h 03m
Frontier
Deal found 3/3![Frontier logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/37:00 am
DSM
- RDU
1 stop6h 43m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2210:55 am
DSM
- CLT
1 stop20h 03m
Frontier
Deal found 3/6![Frontier logo]()
$104
This Expedia deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1710:40 am
DSM
- RDU
1 stop20h 12m
Frontier
Deal found 3/4![Frontier logo]()
$107
This Trip.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1910:40 am
DSM
- RDU
1 stop10h 13m
Frontier
Deal found 3/7![Frontier logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2010:15 am
DSM
- RDU
1 stop21h 45m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/911:00 am
DSM
- RDU
1 stop21h 59m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$113
This CheapOair deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:04 pm
DSM
- CLT
1 stop27h 50m
Frontier
Deal found 3/6![Frontier logo]()
$113
Find flight deals from Des Moines to North Carolina
Keep the following information in mind while searching for Des Moines to North Carolina flight deals. Data was last updated March 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $171 (CheapOair) |
One-way from | $86 (Expedia) |
Popular in | December |
Cheapest in | September |
Average price | $383 |
Good round-trip deal | $386 or less |
Good one-way deal | $243 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to North Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 8, 2026.
Use the filters below to find and compare flights from Des Moines to North Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesAsheville
DSM - AVL
DSMAVL
Des Moines
Sun 3/22
7:00 am-11:23 pm
1 stop15h 23m
Asheville Regional
Wed 3/25
3:25 pm-8:43 pm
2 stops30h 18m
$264
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Wed 4/1
5:35 am-11:17 am
1 stop4h 42m
Knoxville McGhee Tyson
Tue 4/7
5:40 am-10:48 am
1 stop6h 08m
$271
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Wed 3/25
2:59 pm-11:44 pm
1 stop7h 45m
Knoxville McGhee Tyson
Sat 3/28
7:00 am-10:28 am
1 stop4h 28m
$281
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Sat 5/9
5:35 am-10:40 am
1 stop4h 05m
Raleigh-Durham
Tue 5/12
6:10 am-2:05 pm
2 stops8h 55m
$284
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Sat 5/2
2:44 pm-8:57 pm
1 stop5h 13m
Raleigh-Durham
Tue 5/12
6:00 am-10:16 am
1 stop5h 16m
$287
Quickest round-trip
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Sat 5/2
11:51 am-5:04 pm
1 stop4h 13m
Raleigh-Durham
Sat 5/16
6:28 am-11:08 am
1 stop5h 40m
$287
Des MoinesGreensboro
DSM - GSO
DSMGSO
Des Moines
Fri 5/1
11:09 am-7:45 pm
1 stop7h 36m
Greensboro/H. Point
Sun 5/3
8:17 pm-11:49 pm
1 stop4h 32m
$289
Des MoinesGreensboro
DSM - GSO
DSMGSO
Des Moines
Thu 4/2
6:20 am-11:53 am
1 stop4h 33m
Greensboro/H. Point
Thu 4/9
6:15 am-12:29 pm
1 stop7h 14m
$289
Des MoinesAsheville
DSM - AVL
DSMAVL
Des Moines
Sun 4/19
11:09 am-6:30 pm
1 stop6h 21m
Asheville Regional
Sun 4/26
6:00 am-10:26 am
1 stop5h 26m
$289
Des MoinesGreensboro
DSM - GSO
DSMGSO
Des Moines
Thu 4/9
6:20 am-11:53 am
1 stop4h 33m
Greensboro/H. Point
Sun 4/12
6:15 am-10:44 am
1 stop5h 29m
$289
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to North Carolina
Have a flexible travel schedule? Discover the best time to fly to North Carolina from Des Moines with our price prediction graph.
DSM-TYS
DSM-RDU
DSM-ORF
DSM-CLT
DSM-ILM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to North Carolina
DSM-USNC
DSM-TYS
DSM-RDU
DSM-ORF
DSM-CLT
What is the cheapest month to book a flight from Des Moines to North Carolina?
Currently, August is the cheapest month in which you can book a flight from Des Moines to North Carolina (average of $184). Flying from Des Moines to North Carolina in December is currently the most expensive (average of $334). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DSM to NC?
Find hourly flight availability from Des Moines to North Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 8, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to North Carolina as you normally would.
Reviews of airlines servicing North Carolina
Get insights into the airlines that provide service to North Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to North Carolina. Reviews last updated March 8, 2026.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Des Moines to North Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to North Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to North Carolina
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Complete your trip
Complete your trip to North Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and North Carolina flights
Browse other Des Moines and North Carolina flight options. Last updated on March 8, 2026.
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Des Moines to North Carolina flights
Consider these flights traveling from Des Moines to North Carolina.
Top 4 airlines flying from Des Moines to North Carolina
Discover the top 4 airlines that operate flights from Des Moines to North Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$216 | Average$386 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$228 | Average$396 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$357 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$276 | Average$349 | FlexibilityNo cancel fee | On-time69% |