$113+ Cheap flights from Des Moines (DSM) to North Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/30. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CLT
Jul 8 — Jul 151
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to North Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to North Carolina
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to North CarolinaExplore the most affordable flight options available from Des Moines to North Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 8, 2026.
Explore the most affordable flight options available from Des Moines to North Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:12 pm
DSM
- TYS
1 stop28h 12m
Allegiant Air
Sun 8/92:56 pm
TYS
- DSM
1 stop7h 35m
Allegiant Air
Deal found 6/4![Allegiant Air logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:07 pm
DSM
- RDU
1 stop22h 08m
Multiple Airlines
Sun 8/166:35 pm
RDU
- DSM
1 stop5h 44m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/174:40 pm
DSM
- AVL
1 stop24h 09m
Allegiant Air
Thu 7/236:30 am
AVL
- DSM
2 stops35h 10m
Allegiant Air
Deal found 6/6![Allegiant Air logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/184:59 pm
DSM
- AVL
1 stop28h 34m
Allegiant Air
Thu 7/236:30 am
AVL
- DSM
2 stops35h 10m
Allegiant Air
Deal found 6/6![Allegiant Air logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/123:59 pm
DSM
- ORF
1 stop18h 20m
Multiple Airlines
Wed 7/157:06 pm
ORF
- DSM
1 stop29h 01m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:40 pm
DSM
- RDU
1 stop23h 29m
Multiple Airlines
Thu 7/167:05 am
RDU
- DSM
1 stop17h 02m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- TYS
1 stop5h 33m
Allegiant Air
Thu 6/254:05 pm
TYS
- DSM
1 stop6h 42m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/210:57 am
DSM
- TYS
1 stop24h 06m
Allegiant Air
Sun 8/92:56 pm
TYS
- DSM
1 stop7h 35m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
- TYS
1 stop6h 37m
Allegiant Air
Fri 7/108:30 am
TYS
- DSM
1 stop14h 45m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:40 pm
DSM
- RDU
1 stop23h 29m
Multiple Airlines
Sun 7/127:05 am
RDU
- DSM
1 stop15h 53m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:07 pm
DSM
- RDU
1 stop22h 08m
Multiple Airlines
Thu 8/206:15 am
RDU
- DSM
2 stops14h 39m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/204:40 pm
DSM
- AVL
1 stop16h 50m
Allegiant Air
Thu 7/235:46 pm
AVL
- DSM
1 stop23h 04m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$271
Best flights from Des Moines to North CarolinaDiscover carefully curated flight deals from Des Moines to North Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 8, 2026.
Discover carefully curated flight deals from Des Moines to North Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 8, 2026.
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:40 am
DSM
- RDU
1 stop4h 35m
Southwest
Tue 10/68:10 am
RDU
- DSM
1 stop4h 15m
Southwest
Deal found 6/8![Southwest logo]()
$274
This Delta deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/184:47 pm
DSM
- AVL
1 stop4h 45m
Delta
Wed 7/221:14 pm
AVL
- DSM
1 stop4h 38m
Delta
Deal found 6/6![Delta logo]()
$275
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/153:20 pm
DSM
- AVL
1 stop4h 54m
United Airlines
Wed 8/196:49 am
AVL
- DSM
1 stop4h 37m
United Airlines
Deal found 6/6![United Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:07 pm
DSM
- AVL
1 stop15h 24m
Allegiant Air
Fri 8/217:30 am
AVL
- DSM
1 stop7h 33m
Allegiant Air
Deal found 6/4![Allegiant Air logo]()
$303
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:32 am
DSM
- AVL
1 stop6h 12m
American Airlines
Tue 9/86:52 pm
AVL
- DSM
1 stop6h 28m
American Airlines
Deal found 6/3![American Airlines logo]()
$332
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/206:37 pm
DSM
- AVL
1 stop4h 09m
Delta
Sat 7/256:30 am
AVL
- DSM
1 stop5h 15m
Delta
Deal found 6/7![Delta logo]()
$300
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/13:45 pm
DSM
- RDU
1 stop4h 20m
Southwest
Fri 7/31:40 pm
RDU
- DSM
2 stops9h 40m
Southwest
Deal found 6/5![Southwest logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:00 am
DSM
- TYS
1 stop15h 40m
Allegiant Air
Thu 6/184:05 pm
TYS
- DSM
1 stop6h 42m
Allegiant Air
Deal found 6/4![Allegiant Air logo]()
$338
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/234:48 pm
DSM
- TRI
1 stop5h 38m
American Airlines
Sat 6/275:23 pm
TRI
- DSM
1 stop7h 35m
American Airlines
Deal found 6/8![American Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:54 pm
DSM
- TRI
1 stop6h 29m
Delta
Mon 8/315:00 pm
TRI
- DSM
1 stop6h 37m
Delta
Deal found 6/8![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:50 am
DSM
- TYS
1 stop9h 03m
United Airlines
Fri 7/1010:00 am
TYS
- DSM
2 stops12h 22m
United Airlines
Deal found 6/7![United Airlines logo]()
$353
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/295:20 am
DSM
- TYS
2 stops10h 40m
Southwest
Sun 8/27:00 pm
TYS
- DSM
2 stops5h 50m
Southwest
Deal found 6/5![Southwest logo]()
$352
This American Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/155:00 am
DSM
- AVL
1 stop5h 09m
American Airlines
Mon 7/208:15 pm
AVL
- DSM
1 stop4h 54m
American Airlines
Deal found 6/4![American Airlines logo]()
$353
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:39 pm
DSM
- GSO
1 stop4h 20m
Delta
Tue 6/306:00 am
GSO
- DSM
1 stop4h 44m
Delta
Deal found 6/8![Delta logo]()
$334
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:33 pm
DSM
- AVL
1 stop4h 50m
American Airlines
Sun 7/268:15 pm
AVL
- DSM
1 stop4h 54m
American Airlines
Deal found 6/6![American Airlines logo]()
$353
This United Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/293:20 pm
DSM
- GSO
1 stop5h 00m
United Airlines
Tue 9/16:00 am
GSO
- DSM
2 stops11h 19m
United Airlines
Deal found 6/4![United Airlines logo]()
$394
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:10 am
DSM
- TYS
2 stops5h 40m
Southwest
Fri 7/106:40 am
TYS
- DSM
2 stops16h 45m
Southwest
Deal found 6/5![Southwest logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/265:45 pm
DSM
- TYS
1 stop13h 50m
Allegiant Air
Sun 6/284:05 pm
TYS
- DSM
1 stop7h 47m
Allegiant Air
Deal found 6/3![Allegiant Air logo]()
$427
This Delta deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:00 pm
DSM
- RDU
1 stop6h 42m
Delta
Wed 7/156:00 am
RDU
- DSM
1 stop5h 13m
Delta
Deal found 6/6![Delta logo]()
$356
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/94:48 pm
DSM
- TYS
1 stop6h 03m
American Airlines
Mon 7/138:05 pm
TYS
- DSM
1 stop5h 04m
American Airlines
Deal found 6/3![American Airlines logo]()
$357
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/298:00 am
DSM
- ILM
1 stop6h 48m
United Airlines
Tue 9/14:44 pm
ILM
- DSM
1 stop5h 39m
United Airlines
Deal found 6/6![United Airlines logo]()
$400
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:20 am
DSM
- CLT
1 stop4h 50m
Southwest
Wed 8/126:35 pm
CLT
- DSM
1 stop4h 20m
Southwest
Deal found 6/6![Southwest logo]()
$381
This Delta deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:34 pm
DSM
- RDU
1 stop4h 54m
Delta
Wed 7/155:33 am
RDU
- DSM
1 stop5h 12m
Delta
Deal found 6/6![Delta logo]()
$356
This United Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/3111:32 am
DSM
- RDU
1 stop5h 09m
United Airlines
Wed 9/210:05 am
RDU
- DSM
1 stop5h 11m
United Airlines
Deal found 6/3![United Airlines logo]()
$406
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:10 am
DSM
- MYR
2 stops10h 35m
Southwest
Fri 7/107:15 pm
MYR
- DSM
1 stop5h 20m
Southwest
Deal found 6/5![Southwest logo]()
$384
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/274:13 pm
DSM
- TRI
1 stop5h 37m
American Airlines
Mon 8/315:23 pm
TRI
- DSM
1 stop7h 02m
American Airlines
Deal found 6/7![American Airlines logo]()
$388
This Delta deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:41 am
DSM
- AVL
1 stop4h 27m
Delta
Sun 7/2610:05 am
AVL
- DSM
1 stop4h 29m
Delta
Deal found 6/6![Delta logo]()
$357
This United Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:00 am
DSM
- ILM
1 stop6h 37m
United Airlines
Sat 9/54:44 pm
ILM
- DSM
1 stop5h 39m
United Airlines
Deal found 6/3![United Airlines logo]()
$415
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:05 am
DSM
- ORF
1 stop4h 50m
Southwest
Fri 9/116:45 pm
ORF
- DSM
1 stop4h 25m
Southwest
Deal found 6/7![Southwest logo]()
$386
This American Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/284:13 pm
DSM
- TRI
1 stop5h 37m
American Airlines
Mon 8/315:23 pm
TRI
- DSM
1 stop7h 02m
American Airlines
Deal found 6/5![American Airlines logo]()
$388
Last-minute flights from Des Moines to North CarolinaDiscover last-minute flight deals from Des Moines to North Carolina. Data last updated June 8, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to North Carolina. Data last updated June 8, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- TYS
1 stop5h 33m
Allegiant Air
Thu 6/254:05 pm
TYS
- DSM
1 stop6h 42m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
- TYS
1 stop6h 37m
Allegiant Air
Fri 7/108:30 am
TYS
- DSM
1 stop14h 45m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:40 pm
DSM
- RDU
1 stop23h 29m
Multiple Airlines
Thu 7/167:05 am
RDU
- DSM
1 stop17h 02m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:40 pm
DSM
- RDU
1 stop23h 29m
Multiple Airlines
Sun 7/127:05 am
RDU
- DSM
1 stop15h 53m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/123:59 pm
DSM
- ORF
1 stop18h 20m
Multiple Airlines
Wed 7/157:06 pm
ORF
- DSM
1 stop29h 01m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/169:23 am
DSM
- AVL
1 stop12h 10m
Allegiant Air
Thu 7/234:45 pm
AVL
- DSM
1 stop27h 19m
Allegiant Air
Deal found 6/3![Allegiant Air logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/165:08 pm
DSM
- AVL
2 stops28h 51m
Multiple Airlines
Thu 7/235:46 pm
AVL
- DSM
1 stop23h 04m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/174:40 pm
DSM
- AVL
1 stop24h 09m
Allegiant Air
Thu 7/236:30 am
AVL
- DSM
2 stops35h 10m
Allegiant Air
Deal found 6/6![Allegiant Air logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/174:40 pm
DSM
- AVL
1 stop24h 09m
Multiple Airlines
Thu 7/236:30 am
AVL
- DSM
2 stops17h 37m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/184:59 pm
DSM
- AVL
1 stop28h 34m
Allegiant Air
Thu 7/236:30 am
AVL
- DSM
2 stops35h 10m
Allegiant Air
Deal found 6/6![Allegiant Air logo]()
$254
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/184:47 pm
DSM
- AVL
1 stop4h 45m
Delta
Sat 7/256:30 am
AVL
- DSM
1 stop5h 15m
Delta
Deal found 6/7![Delta logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/205:30 pm
DSM
- AVL
2 stops15h 05m
Allegiant Air
Thu 7/235:46 pm
AVL
- DSM
1 stop23h 04m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$279
One-way flights from Des Moines to North CarolinaSearch for one-way flight options from Des Moines to North Carolina. Find affordable one-way fares based on user searches. Data last updated June 8, 2026.
Search for one-way flight options from Des Moines to North Carolina. Find affordable one-way fares based on user searches. Data last updated June 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:08 pm
DSM
- ORF
1 stop17h 11m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$113
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/144:01 pm
DSM
- TYS
1 stop28h 49m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/95:12 pm
DSM
- ORF
1 stop17h 07m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$120
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:10 am
DSM
- ORF
1 stop4h 55m
Southwest
Deal found 6/7![Southwest logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2110:05 am
DSM
- RDU
1 stop22h 03m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$125
This Booking.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/152:19 pm
DSM
- RDU
1 stop20h 12m
Frontier
Deal found 6/5![Frontier logo]()
$126
This CheapOair deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- CLT
1 stop27h 03m
Frontier
Deal found 6/5![Frontier logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/34:40 pm
DSM
- CLT
1 stop27h 27m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/314:40 pm
DSM
- CLT
1 stop27h 27m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/193:59 pm
DSM
- ORF
1 stop18h 20m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/26:00 am
DSM
- CLT
2 stops38h 07m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- TYS
1 stop5h 33m
Allegiant Air
Deal found 6/7![Allegiant Air logo]()
$141
Find flight deals from Des Moines to North Carolina
Keep the following information in mind while searching for Des Moines to North Carolina flight deals. Data was last updated June 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $212 (Kiwi.com) |
One-way from | $113 (Kiwi.com) |
Popular in | April |
Cheapest in | September |
Average price | $350 |
Good round-trip deal | $426 or less |
Good one-way deal | $241 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to North Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 8, 2026.
Use the filters below to find and compare flights from Des Moines to North Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Sat 10/3
5:40 am-11:15 am
1 stop4h 35m
Raleigh-Durham
Tue 10/6
8:10 am-11:25 am
1 stop4h 15m
$274
Des MoinesAsheville
DSM - AVL
DSMAVL
Des Moines
Sat 7/18
4:47 pm-10:32 pm
1 stop4h 45m
Asheville Regional
Wed 7/22
1:14 pm-4:52 pm
1 stop4h 38m
$275
Des MoinesAsheville
DSM - AVL
DSMAVL
Des Moines
Sat 8/15
3:20 pm-9:14 pm
1 stop4h 54m
Asheville Regional
Wed 8/19
6:49 am-10:26 am
1 stop4h 37m
$275
Des MoinesAsheville
DSM - AVL
DSMAVL
Des Moines
Mon 7/20
6:37 pm-11:46 pm
1 stop4h 09m
Asheville Regional
Sat 7/25
6:30 am-10:45 am
1 stop5h 15m
$300
Des MoinesAsheville
DSM - AVL
DSMAVL
Des Moines
Mon 8/17
6:07 pm-10:31 am
1 stop15h 24m
Asheville Regional
Fri 8/21
7:30 am-2:03 pm
1 stop7h 33m
$303
Des MoinesBlountville
DSM - TRI
DSMTRI
Des Moines
Fri 8/28
2:54 pm-10:23 pm
1 stop6h 29m
Blountville Tri Cities TN/VA
Mon 8/31
5:00 pm-10:37 pm
1 stop6h 37m
$319
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Wed 7/1
3:45 pm-9:05 pm
1 stop4h 20m
Raleigh-Durham
Fri 7/3
1:40 pm-10:20 pm
2 stops9h 40m
$321
Des MoinesAsheville
DSM - AVL
DSMAVL
Des Moines
Sat 9/5
9:32 am-4:44 pm
1 stop6h 12m
Asheville Regional
Tue 9/8
6:52 pm-12:20 am
1 stop6h 28m
$332
Des MoinesGreensboro
DSM - GSO
DSMGSO
Des Moines
Wed 6/24
6:39 pm-11:59 pm
1 stop4h 20m
Greensboro/H. Point
Tue 6/30
6:00 am-9:44 am
1 stop4h 44m
$334
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Mon 6/15
6:00 am-10:40 pm
1 stop15h 40m
Knoxville McGhee Tyson
Thu 6/18
4:05 pm-9:47 pm
1 stop6h 42m
$338
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to North Carolina
Have a flexible travel schedule? Discover the best time to fly to North Carolina from Des Moines with our price prediction graph.
DSM-RDU
DSM-AVL
DSM-TYS
DSM-TRI
DSM-GSO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to North Carolina
DSM-USNC
DSM-RDU
DSM-AVL
DSM-TYS
DSM-TRI
What is the cheapest month to book a flight from Des Moines to North Carolina?
Currently, March is the cheapest month in which you can book a flight from Des Moines to North Carolina (average of $155). Flying from Des Moines to North Carolina in December is currently the most expensive (average of $309). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DSM to NC?
Find hourly flight availability from Des Moines to North Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 8, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to North Carolina as you normally would.
Weekly flight availability from Des Moines to North Carolina
Explore weekly flight availability from Des Moines to North Carolina. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 8, 2026.
The most flights from DSM to USNC are scheduled on a Monday (2 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).
How much does it cost to fly round-trip from Des Moines to North Carolina?
How far ahead should I book a flight from Des Moines to North Carolina?
The best time to book flights from Des Moines to North Carolina is 40 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
Reviews of airlines servicing North Carolina
Get insights into the airlines that provide service to North Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to North Carolina. Reviews last updated June 8, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to North Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Overall
7.9
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Des Moines to North Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Des Moines to North Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to North Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to North Carolina by cabin class
Find flights from Des Moines to North Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and North Carolina flights
Browse other Des Moines and North Carolina flight options. Last updated on June 8, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to North Carolina flights
Consider these flights traveling from Des Moines to North Carolina.
Top 4 airlines flying from Des Moines to North Carolina
Discover the top 4 airlines that operate flights from Des Moines to North Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$216 | Average$377 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$236 | Average$381 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$376 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$268 | Average$383 | FlexibilityNo cancel fee | On-time69% |