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$156+ Cheap flights from Des Moines to Key West (DSM - EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Feb 6 — Feb 131
Fri 2/6
Fri 2/13
1 adult, Economy
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Cheap flight deals from Des Moines to Key West

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 7, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$268
(American Airlines)

One-way from

$156
(Kiwi.com)

Popular in

June

Cheapest in

April

Average price

$543
Provider with most accurate pricing for Des Moines-Key West flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Key West flights.
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From Des Moines to Key West
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One-way flight from Des Moines to Key West
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Highest demand for flights based on searches. 10% potential increase in price ($54 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Des Moines to Key West

Cheapest flights from Des Moines to Key West
Explore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 7, 2026.

This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:32 amDSM - EYW
1 stop10h 47mAmerican Airlines
Wed 2/256:53 pmEYW - DSM
1 stop5h 47mAmerican Airlines
Deal found 1/6$268
This Kiwi.com deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/216:14 pmDSM - EYW
1 stop19h 05mMultiple Airlines
Thu 2/262:25 pmEYW - DSM
1 stop9h 41mMultiple Airlines
Deal found 1/5$271
This Kiwi.com deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/207:17 pmDSM - EYW
2 stops36h 49mMultiple Airlines
Thu 2/262:25 pmEYW - DSM
1 stop9h 41mMultiple Airlines
Deal found 1/4$280
This Delta deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:19 amDSM - EYW
2 stops12h 23mDelta
Thu 2/261:28 pmEYW - DSM
1 stop7h 08mDelta
Deal found 1/4$284
This United Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/48:00 amDSM - EYW
1 stop6h 17mUnited Airlines
Wed 2/114:15 pmEYW - DSM
1 stop6h 35mUnited Airlines
Deal found 1/7$289
This American Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:00 amDSM - EYW
1 stop6h 42mAmerican Airlines
Tue 8/47:33 pmEYW - DSM
1 stop5h 18mAmerican Airlines
Deal found 1/7$309

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Des Moines

Fly to

Key West

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 2/17

12:02 pm-7:42 pm

1 stop6h 40m

Key West

Thu 2/26

1:28 pm-7:36 pm

1 stop7h 08m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Thu 3/5

2:02 pm-10:37 pm

1 stop7h 35m

Key West

Mon 3/9

6:49 pm-11:40 pm

1 stop5h 51m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 2/4

8:00 am-3:17 pm

1 stop6h 17m

Key West

Wed 2/11

4:15 pm-9:50 pm

1 stop6h 35m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 2/21

2:02 pm-10:37 pm

1 stop7h 35m

Key West

Thu 2/26

6:53 pm-11:40 pm

1 stop5h 47m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 3/4

5:00 am-3:57 pm

2 stops9h 57m

Key West

Mon 3/9

6:49 pm-11:40 pm

1 stop5h 51m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 2/18

5:00 am-3:57 pm

2 stops9h 57m

Key West

Wed 2/25

1:55 pm-11:40 pm

2 stops10h 45m

$300

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 1/27

8:00 am-3:17 pm

1 stop6h 17m

Key West

Sat 1/31

4:15 pm-9:50 pm

1 stop6h 35m

$314

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 1/26

8:00 am-3:17 pm

1 stop6h 17m

Key West

Sat 1/31

4:15 pm-9:50 pm

1 stop6h 35m

$319

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 1/27

7:00 am-3:25 pm

1 stop7h 25m

Key West

Sat 1/31

7:15 am-4:24 pm

2 stops10h 09m

$324

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 2/4

6:24 am-7:40 pm

2 stops12h 16m

Key West

Wed 2/11

6:06 pm-10:29 pm

1 stop5h 23m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/7

Showing 1-10 of 16 results
1
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Compare providers for flights from Des Moines to Key West

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Key West in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Key West flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Key West flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Key West flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Key West flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Key West

How far ahead should I book a flight from Des Moines to Key West?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Key West. Price data was last updated on January 2, 2026.

The price you pay for your flight from Des Moines to Key West may vary depending on when you book. For the best chance of a lower fare, look to book 35 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Key West?

Currently, July is the cheapest month in which you can book a flight from Des Moines to Key West (average of $77). Flying from Des Moines to Key West in December is currently the most expensive (average of $371). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated January 7, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Key West to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,022 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,022 reviews
Delta
7.9
Good
8,022 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,138 reviews
Delta
7.9
Good
8,022 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,088 reviews
Delta
7.9
Good
8,022 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.2
Good
702 reviews
Delta
7.9
Good
8,022 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Key West?

    Departing from Des Moines to Key West will take you 6h 17m. The distance between Des Moines and Key West is about 1357 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Des Moines to Key West round-trip?

    Allegiant Air, at $76, was found to be the cheapest airline from Des Moines to Key West.Alternate airlines to your destination round-trip include American Airlines and Delta. Users have found that Allegiant Air is 83% cheaper than the other options available to this destination.

  • Can I find deals for flights from Des Moines to Key West that include hotel bookings?

    Yes. In addition to deals on Des Moines to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Key West.

  • Can I find deals for business class flights from Des Moines to Key West?

    Yes. Cheapflights offers flight deals from Des Moines to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Key West?

    Currently, July is the cheapest month in which you can book a flight from Des Moines to Key West (average of $77). Flying from Des Moines to Key West in December is currently the most expensive (average of $371). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Des Moines to Key West

Discover the top 4 airlines that operate flights from Des Moines to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$174FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$268Average$542FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$498FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$281Average$498FlexibilityNo cancel feeOn-time69%

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