$181+ Cheap flights from Des Moines to Key West (DSM - EYW)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/30. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Apr 7 — Apr 141
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Key West with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Key West
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to Key WestExplore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 8, 2026.
Explore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- EYW
1 stop21h 50m
Allegiant Air
Sat 6/272:48 pm
EYW
- DSM
1 stop9h 04m
Allegiant Air
Deal found 3/7![Allegiant Air logo]()
$288
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:56 pm
DSM
- EYW
1 stop13h 10m
Multiple Airlines
Wed 3/2512:25 pm
EYW
- DSM
1 stop26h 04m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/32:36 pm
DSM
- EYW
1 stop21h 59m
Multiple Airlines
Wed 5/611:46 am
EYW
- DSM
2 stops28h 29m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1710:40 am
DSM
- EYW
1 stop23h 31m
Multiple Airlines
Wed 3/2512:25 pm
EYW
- DSM
1 stop26h 04m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/207:51 pm
DSM
- EYW
1 stop17h 51m
Multiple Airlines
Wed 3/2512:25 pm
EYW
- DSM
1 stop26h 04m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$307
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/173:00 pm
DSM
- EYW
1 stop6h 36m
American Airlines
Fri 4/246:46 pm
EYW
- DSM
1 stop6h 03m
American Airlines
Deal found 3/3![American Airlines logo]()
$308
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:09 am
DSM
- EYW
1 stop6h 07m
American Airlines
Mon 4/276:46 pm
EYW
- DSM
1 stop6h 03m
American Airlines
Deal found 3/3![American Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:09 am
DSM
- EYW
2 stops10h 27m
American Airlines
Tue 4/286:49 pm
EYW
- DSM
1 stop6h 00m
American Airlines
Deal found 3/3![American Airlines logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:56 pm
DSM
- EYW
1 stop13h 10m
Multiple Airlines
Tue 3/241:01 pm
EYW
- DSM
2 stops31h 15m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$317
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1111:09 am
DSM
- EYW
2 stops10h 27m
American Airlines
Wed 4/1511:24 am
EYW
- DSM
2 stops11h 54m
American Airlines
Deal found 3/7![American Airlines logo]()
$319
Best flights from Des Moines to Key WestDiscover carefully curated flight deals from Des Moines to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 8, 2026.
Discover carefully curated flight deals from Des Moines to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 8, 2026.
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/11:52 pm
DSM
- EYW
1 stop7h 45m
American Airlines
Wed 4/86:46 pm
EYW
- DSM
1 stop6h 03m
American Airlines
Deal found 3/4![American Airlines logo]()
$309
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:20 am
DSM
- EYW
2 stops9h 22m
United Airlines
Wed 4/153:52 pm
EYW
- DSM
1 stop8h 25m
United Airlines
Deal found 3/7![United Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:15 am
DSM
- EYW
2 stops12h 26m
Delta
Wed 4/157:33 am
EYW
- DSM
1 stop7h 22m
Delta
Deal found 3/7![Delta logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/207:51 pm
DSM
- EYW
1 stop17h 51m
Multiple Airlines
Tue 3/241:01 pm
EYW
- DSM
2 stops31h 15m
Multiple Airlines
Deal found 3/4![Multiple Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2512:00 pm
DSM
- EYW
2 stops9h 58m
American Airlines
Wed 4/296:46 pm
EYW
- DSM
1 stop6h 03m
American Airlines
Deal found 3/8![American Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2511:09 am
DSM
- EYW
1 stop6h 07m
American Airlines
Tue 4/286:49 pm
EYW
- DSM
1 stop6h 00m
American Airlines
Deal found 3/8![American Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:19 am
DSM
- EYW
2 stops12h 21m
Delta
Sat 5/27:33 am
EYW
- DSM
1 stop7h 22m
Delta
Deal found 3/5![Delta logo]()
$399
This United Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:20 am
DSM
- EYW
1 stop7h 31m
United Airlines
Wed 4/293:52 pm
EYW
- DSM
1 stop8h 25m
United Airlines
Deal found 3/4![United Airlines logo]()
$409
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2011:33 am
DSM
- EYW
1 stop4h 57m
Delta
Tue 3/241:22 pm
EYW
- DSM
1 stop7h 05m
Delta
Deal found 3/8![Delta logo]()
$474
Last-minute flights from Des Moines to Key WestDiscover last-minute flight deals from Des Moines to Key West. Data last updated March 8, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Key West. Data last updated March 8, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1710:40 am
DSM
- EYW
1 stop23h 31m
Multiple Airlines
Wed 3/2512:25 pm
EYW
- DSM
1 stop26h 04m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1710:40 am
DSM
- EYW
1 stop23h 31m
Multiple Airlines
Tue 3/241:01 pm
EYW
- DSM
2 stops31h 15m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/197:53 pm
DSM
- EYW
1 stop17h 16m
Multiple Airlines
Wed 3/2512:25 pm
EYW
- DSM
1 stop26h 04m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$320
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/207:51 pm
DSM
- EYW
1 stop17h 51m
Multiple Airlines
Wed 3/2512:25 pm
EYW
- DSM
1 stop26h 04m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:56 pm
DSM
- EYW
1 stop13h 10m
Multiple Airlines
Wed 3/2512:25 pm
EYW
- DSM
1 stop26h 04m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/216:56 pm
DSM
- EYW
1 stop13h 10m
Multiple Airlines
Tue 3/241:01 pm
EYW
- DSM
2 stops31h 15m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$317
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1111:09 am
DSM
- EYW
2 stops10h 27m
American Airlines
Wed 4/154:20 pm
EYW
- DSM
2 stops8h 39m
American Airlines
Deal found 3/7![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/173:00 pm
DSM
- EYW
1 stop6h 36m
American Airlines
Fri 4/246:46 pm
EYW
- DSM
1 stop6h 03m
American Airlines
Deal found 3/3![American Airlines logo]()
$308
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:09 am
DSM
- EYW
1 stop6h 07m
American Airlines
Mon 4/276:46 pm
EYW
- DSM
1 stop6h 03m
American Airlines
Deal found 3/3![American Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2511:09 am
DSM
- EYW
1 stop6h 07m
American Airlines
Tue 4/286:49 pm
EYW
- DSM
1 stop6h 00m
American Airlines
Deal found 3/8![American Airlines logo]()
$329
One-way flights from Des Moines to Key WestSearch for one-way flight options from Des Moines to Key West. Find affordable one-way fares based on user searches. Data last updated March 8, 2026.
Search for one-way flight options from Des Moines to Key West. Find affordable one-way fares based on user searches. Data last updated March 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:16 pm
DSM
- EYW
1 stop17h 09m
Multiple Airlines
Deal found 3/7![Multiple Airlines logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:40 pm
DSM
- EYW
2 stops18h 54m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$218
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/198:56 am
DSM
- EYW
1 stop8h 20m
American Airlines
Deal found 3/5![American Airlines logo]()
$313
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:10 am
DSM
- EYW
2 stops12h 30m
Delta
Deal found 3/5![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/67:00 am
DSM
- EYW
1 stop8h 12m
American Airlines
Deal found 3/5![American Airlines logo]()
$344
Find flight deals from Des Moines to Key West
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $288 (Kiwi.com) |
One-way from | $181 (Kiwi.com) |
Popular in | February |
Cheapest in | September |
Average price | $446 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 8, 2026.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Wed 4/1
1:52 pm-10:37 pm
1 stop7h 45m
Key West
Wed 4/8
6:46 pm-11:49 pm
1 stop6h 03m
$309
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 4/11
6:20 am-4:42 pm
2 stops9h 22m
Key West
Wed 4/15
3:52 pm-11:17 pm
1 stop8h 25m
$314
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 4/11
6:15 am-7:41 pm
2 stops12h 26m
Key West
Wed 4/15
7:33 am-1:55 pm
1 stop7h 22m
$314
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 4/25
12:00 pm-10:58 pm
2 stops9h 58m
Key West
Wed 4/29
6:46 pm-11:49 pm
1 stop6h 03m
$314
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 4/25
11:09 am-6:16 pm
1 stop6h 07m
Key West
Tue 4/28
6:49 pm-11:49 pm
1 stop6h 00m
$329
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Fri 3/20
7:51 pm-2:42 pm
1 stop17h 51m
Key West
Tue 3/24
1:01 pm-7:16 pm
2 stops31h 15m
$335
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 4/25
6:19 am-7:40 pm
2 stops12h 21m
Key West
Sat 5/2
7:33 am-1:55 pm
1 stop7h 22m
$399
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 4/25
6:20 am-2:51 pm
1 stop7h 31m
Key West
Wed 4/29
3:52 pm-11:17 pm
1 stop8h 25m
$409
Quickest round-trip
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Fri 3/20
11:33 am-5:30 pm
1 stop4h 57m
Key West
Tue 3/24
1:22 pm-7:27 pm
1 stop7h 05m
$474
Cheapest one-way
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Mon 7/6
4:40 pm-12:34 pm
2 stops18h 54m
$218
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Key West
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Key West in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Key West flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Key West flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Des Moines with our price prediction graph.
DSM-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Key West
Reviews of airlines servicing Key West
Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated March 8, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and Allegiant Air from Des Moines to Key West to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Crew
8.5
Comfort
7.9
Overall
7.9
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Crew
8.5
Comfort
7.9
Overall
7.9
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Crew
8.5
Comfort
7.9
Overall
7.9
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Crew
8.5
Comfort
7.9
Overall
7.9
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Crew
8.5
Comfort
7.9
Overall
7.9
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Other flights to Key West
Explore flights to Key West departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 8, 2026.
Des Moines and Key West flights
Browse other Des Moines and Key West flight options. Last updated on March 8, 2026.
Other flights from Des Moines
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Top 4 airlines flying from Des Moines to Key West
Discover the top 4 airlines that operate flights from Des Moines to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$76 | Average$174 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$268 | Average$465 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$268 | Average$488 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$288 | Average$447 | FlexibilityNo cancel fee | On-time69% |