$166+ Cheap flights from Des Moines to Key West (DSM - EYW)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Dec 23 — Dec 301
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Find flight deals from Des Moines to Key West
Cheapest flights from Des Moines to Key WestExplore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 23, 2025.
Explore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 23, 2025.
This Delta deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1311:23 amDSM - EYW
1 stop7h 43mDelta
Wed 12/176:10 pmEYW - DSM
1 stop5h 24mDelta
Deal found 11/20![Delta logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/610:38 amDSM - EYW
1 stop28h 06mMultiple Airlines
Wed 12/1010:47 amEYW - DSM
2 stops36h 34mMultiple Airlines
Deal found 11/21![Multiple Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:31 amDSM - EYW
2 stops25h 49mMultiple Airlines
Mon 12/2910:01 pmEYW - DSM
1 stop26h 00mMultiple Airlines
Deal found 11/21![Multiple Airlines logo]()
$301
This American Airlines deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/66:00 amDSM - EYW
1 stop8h 46mAmerican Airlines
Sat 12/134:59 pmEYW - DSM
1 stop7h 00mAmerican Airlines
Deal found 11/21![American Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/66:17 amDSM - EYW
2 stops12h 49mDelta
Sat 12/136:10 pmEYW - DSM
1 stop5h 24mDelta
Deal found 11/21![Delta logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:31 amDSM - EYW
2 stops25h 49mMultiple Airlines
Sun 12/2810:37 pmEYW - DSM
1 stop18h 03mMultiple Airlines
Deal found 11/21![Multiple Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:31 amDSM - EYW
2 stops25h 49mMultiple Airlines
Tue 12/3010:32 pmEYW - DSM
1 stop15h 23mMultiple Airlines
Deal found 11/21![Multiple Airlines logo]()
$338
This American Airlines deal was found by Cheapflights users on 11/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/66:00 amDSM - EYW
1 stop8h 46mAmerican Airlines
Wed 12/104:10 pmEYW - DSM
1 stop8h 19mAmerican Airlines
Deal found 11/21![American Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:28 pmDSM - EYW
2 stops37h 39mMultiple Airlines
Fri 12/123:54 pmEYW - DSM
1 stop8h 18mMultiple Airlines
Deal found 11/23![Multiple Airlines logo]()
$344
Cheap flight deals from Des Moines to Key West
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 23, 2025.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $264 (American Airlines) |
One-way from | $166 (Mytrip) |
Popular in | June |
Cheapest in | April |
Average price | $348 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 23, 2025.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.
Fly from
Des Moines
Fly to
Key West
Route
Depart
Return
Price
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Fri 1/9
7:00 am-3:25 pm
1 stop7h 25m
Key West
Mon 1/12
6:43 pm-11:08 pm
1 stop5h 25m
$269
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 12/13
11:23 am-8:06 pm
1 stop7h 43m
Key West
Wed 12/17
6:10 pm-10:34 pm
1 stop5h 24m
$269
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Wed 1/7
7:00 am-3:25 pm
1 stop7h 25m
Key West
Wed 1/14
6:43 pm-11:08 pm
1 stop5h 25m
$270
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Wed 1/7
6:14 pm-9:37 pm
1 stop26h 23m
Key West
Wed 1/14
10:49 am-10:46 pm
2 stops36h 57m
$271
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Fri 1/9
11:42 am-11:56 pm
2 stops11h 14m
Key West
Wed 1/14
4:04 pm-11:08 pm
1 stop8h 04m
$274
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Wed 1/7
6:24 am-7:40 pm
2 stops12h 16m
Key West
Wed 1/14
12:24 pm-8:54 pm
2 stops9h 30m
$279
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Fri 1/9
6:24 am-7:40 pm
2 stops12h 16m
Key West
Wed 1/14
12:24 pm-8:54 pm
2 stops9h 30m
$279
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Wed 12/24
8:31 am-11:20 am
2 stops25h 49m
Key West
Mon 12/29
10:01 pm-11:01 pm
1 stop26h 00m
$301
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 12/6
6:17 am-5:15 pm
2 stops9h 58m
Key West
Sat 12/13
6:10 pm-10:34 pm
1 stop5h 24m
$309
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Thu 1/15
4:30 pm-1:30 pm
2 stops20h 00m
$166
Compare providers for flights from Des Moines to Key West
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Key West in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*1 star | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Key West flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Key West flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Key West flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Key West flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Key West
How far ahead should I book a flight from Des Moines to Key West?
Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Key West. Price data was last updated on November 21, 2025.
The price you pay for your flight from Des Moines to Key West may vary depending on when you book. For the best chance of a lower fare, look to book 35 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to Key West?
Currently, July is the cheapest month in which you can book a flight from Des Moines to Key West (average of $82). Flying from Des Moines to Key West in August is currently the most expensive (average of $324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Key West
Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated November 23, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Key West to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Food
7.3
Overall
7.9
Comfort
7.9
Boarding
8.1
Entertainment
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Food
7.3
Overall
7.9
Comfort
7.9
Boarding
8.1
Entertainment
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Food
7.3
Overall
7.9
Comfort
7.9
Boarding
8.1
Entertainment
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Food
7.3
Overall
7.9
Comfort
7.9
Boarding
8.1
Entertainment
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Food
7.3
Overall
7.9
Comfort
7.9
Boarding
8.1
Entertainment
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Key West
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from Des Moines to Key West
Discover the top 4 airlines that operate flights from Des Moines to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 23, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$76 | Average$157 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$268 | Average$517 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$268 | Average$475 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$281 | Average$502 | FlexibilityNo cancel fee | On-time69% |