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$211+ Cheap flights from Des Moines to Key West (DSM - EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Nov 19 — Nov 261
Wed 11/19
Wed 11/26
1 adult, Economy
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Find flight deals from Des Moines to Key West

Cheapest flights from Des Moines to Key West
Explore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2025.

This Mytrip deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/22:51 pmDSM - EYW
2 stops28h 30mAllegiant Air
Thu 11/68:36 pmEYW - DSM
1 stop12h 54mAllegiant Air
Deal found 10/18$264
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:35 amDSM - EYW
1 stop6h 08mAmerican Airlines
Sat 12/134:59 pmEYW - DSM
1 stop7h 00mAmerican Airlines
Deal found 10/19$269
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:08 pmDSM - EYW
1 stop6h 37mAmerican Airlines
Thu 12/118:00 amEYW - DSM
1 stop8h 37mAmerican Airlines
Deal found 10/19$270
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/612:15 pmDSM - EYW
2 stops9h 52mAmerican Airlines
Wed 12/107:30 amEYW - DSM
1 stop8h 03mAmerican Airlines
Deal found 10/19$274
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/159:02 amDSM - EYW
2 stops11h 47mAmerican Airlines
Wed 11/191:33 pmEYW - DSM
2 stops10h 57mAmerican Airlines
Deal found 10/18$279
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:57 pmDSM - EYW
2 stops9h 10mAmerican Airlines
Wed 12/107:30 amEYW - DSM
2 stops9h 55mAmerican Airlines
Deal found 10/19$280
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1410:08 amDSM - EYW
1 stop21h 53mAllegiant Air
Fri 11/214:12 pmEYW - DSM
1 stop6h 29mAllegiant Air
Deal found 10/20$293
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/143:18 pmDSM - EYW
1 stop6h 09mAmerican Airlines
Fri 11/217:00 amEYW - DSM
2 stops7h 22mAmerican Airlines
Deal found 10/20$304
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/43:18 pmDSM - EYW
1 stop5h 30mAmerican Airlines
Sat 11/84:59 pmEYW - DSM
1 stop7h 00mAmerican Airlines
Deal found 10/20$319

Cheap flight deals from Des Moines to Key West

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$264
(Mytrip)

One-way from

$211
(Kiwi.com)

Popular in

June

Cheapest in

April

Average price

$398
Provider with most accurate pricing for Des Moines-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Key West flights.
Search Deals
From Des Moines to Key West
Search Deals
One-way flight from Des Moines to Key West
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($83 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 20, 2025.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Des Moines

Fly to

Key West

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 11/15

11:28 am-7:53 pm

1 stop7h 25m

Key West

Wed 11/19

7:40 am-1:32 pm

1 stop6h 52m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/6

6:00 am-3:46 pm

1 stop8h 46m

Key West

Sat 12/13

4:59 pm-10:59 pm

1 stop7h 00m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 1/13

11:04 am-5:13 pm

1 stop5h 09m

Key West

Wed 1/21

1:30 pm-8:03 pm

1 stop7h 33m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 12/12

3:18 pm-10:18 pm

1 stop6h 00m

Key West

Mon 12/15

7:00 am-2:51 pm

2 stops8h 51m

$274

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/6

12:15 pm-11:07 pm

2 stops9h 52m

Key West

Wed 12/10

7:30 am-2:33 pm

1 stop8h 03m

$274

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 12/3

3:18 pm-9:46 pm

1 stop5h 28m

Key West

Wed 12/10

7:00 am-4:35 pm

2 stops10h 35m

$274

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Thu 12/4

2:08 pm-9:45 pm

1 stop6h 37m

Key West

Thu 12/11

7:00 am-3:37 pm

2 stops9h 37m

$275

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 11/21

5:30 pm-12:11 pm

1 stop17h 41m

$211

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 11/21

9:34 am-1:29 pm

2 stops26h 55m

$221

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 11/14

8:02 am-3:19 pm

1 stop6h 17m

$360

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/19

Compare providers for flights from Des Moines to Key West

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Key West in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Key West flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Key West flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Key West

How far ahead should I book a flight from Des Moines to Key West?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Key West. Price data was last updated on October 17, 2025.

The price you pay for your flight from Des Moines to Key West may vary depending on when you book. For the best chance of a lower fare, look to book 35 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Key West?

Currently, July is the cheapest month in which you can book a flight from Des Moines to Key West (average of $82). Flying from Des Moines to Key West in June is currently the most expensive (average of $326). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated October 20, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Key West to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,978 reviews

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,978 reviews
Delta
7.9
Good
7,978 reviews

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,991 reviews
Delta
7.9
Good
7,978 reviews

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,024 reviews
Delta
7.9
Good
7,978 reviews

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Allegiant Air
7.2
Good
694 reviews
Delta
7.9
Good
7,978 reviews

Comfort

7.9

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Key West?

    Departing from Des Moines to Key West will take you 6h 08m. The distance between Des Moines and Key West is about 1357 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Des Moines to Key West round-trip?

    Allegiant Air, at $76, was found to be the cheapest airline from Des Moines to Key West.Alternate airlines to your destination round-trip include American Airlines and Delta. Users have found that Allegiant Air is 82% cheaper than the other options available to this destination.

  • Can I find deals for flights from Des Moines to Key West that include hotel bookings?

    Yes. In addition to deals on Des Moines to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Key West.

  • Can I find deals for business class flights from Des Moines to Key West?

    Yes. Cheapflights offers flight deals from Des Moines to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Key West?

    Currently, July is the cheapest month in which you can book a flight from Des Moines to Key West (average of $82). Flying from Des Moines to Key West in June is currently the most expensive (average of $326). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Des Moines to Key West

Discover the top 4 airlines that operate flights from Des Moines to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$157FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$268Average$498FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$470FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$281Average$508FlexibilityNo cancel feeOn-time69%

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