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Key West

$134+ Cheap flights from Des Moines to Key West (DSM - EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Find flight deals from Des Moines to Key West

Cheapest flights from Des Moines to Key West
Explore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/271:10 pmDSM - EYW
1 stop5h 43mDelta
Tue 12/26:10 pmEYW - DSM
1 stop5h 24mDelta
Deal found 11/11$264
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/66:00 amDSM - EYW
1 stop8h 46mAmerican Airlines
Sat 12/138:00 amEYW - DSM
1 stop6h 19mAmerican Airlines
Deal found 11/11$269
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/66:17 amDSM - EYW
2 stops12h 49mDelta
Sat 12/136:10 pmEYW - DSM
1 stop5h 24mDelta
Deal found 11/12$274
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/11:06 pmDSM - EYW
2 stops9h 44mAmerican Airlines
Wed 12/171:45 pmEYW - DSM
2 stops9h 44mAmerican Airlines
Deal found 11/11$314
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2811:28 amDSM - EYW
1 stop4h 55mDelta
Tue 12/26:10 pmEYW - DSM
1 stop5h 24mDelta
Deal found 11/12$339
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2811:30 amDSM - EYW
2 stops11h 20mAmerican Airlines
Tue 12/27:00 amEYW - DSM
2 stops8h 31mAmerican Airlines
Deal found 11/12$349
This Mytrip deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/279:51 amDSM - EYW
1 stop4h 54mAllegiant Air
Mon 12/13:35 pmEYW - DSM
1 stop6h 26mAllegiant Air
Deal found 11/11$355
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:17 amDSM - EYW
2 stops12h 36mDelta
Mon 12/16:18 pmEYW - DSM
1 stop5h 15mDelta
Deal found 11/11$384

Cheap flight deals from Des Moines to Key West

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 13, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$264
(Delta)

One-way from

$134
(Kiwi.com)

Popular in

June

Cheapest in

April

Average price

$393
Provider with most accurate pricing for Des Moines-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Key West flights.
Search Deals
From Des Moines to Key West
Search Deals
One-way flight from Des Moines to Key West
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($75 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Des Moines

Fly to

Key West

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Thu 11/27

1:10 pm-7:53 pm

1 stop5h 43m

Key West

Tue 12/2

6:10 pm-10:34 pm

1 stop5h 24m

$264

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 1/17

11:42 am-11:56 pm

2 stops11h 14m

Key West

Wed 1/21

6:43 pm-11:08 pm

1 stop5h 25m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 12/10

2:16 pm-8:06 pm

1 stop4h 50m

Key West

Wed 12/17

6:10 pm-10:34 pm

1 stop5h 24m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 1/23

11:42 am-9:47 pm

2 stops9h 05m

Key West

Mon 1/26

4:37 pm-11:59 pm

1 stop8h 22m

$274

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 1/10

6:00 am-4:07 pm

1 stop9h 07m

Key West

Fri 1/16

1:22 pm-10:11 pm

2 stops9h 49m

$274

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/6

6:17 am-8:06 pm

2 stops12h 49m

Key West

Sat 12/13

6:10 pm-10:34 pm

1 stop5h 24m

$274

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 1/31

11:42 am-9:47 pm

2 stops9h 05m

Key West

Fri 2/6

4:01 pm-9:04 pm

1 stop6h 03m

$274

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 1/9

6:24 am-7:42 pm

2 stops12h 18m

Key West

Mon 1/12

6:08 pm-10:31 pm

1 stop5h 23m

$274

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 1/9

6:00 am-4:49 pm

2 stops9h 49m

Key West

Mon 1/12

4:37 pm-11:08 pm

2 stops7h 31m

$279

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Mon 12/1

2:28 pm-11:05 am

1 stop19h 37m

$134

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/11

Showing 1-10 of 15 results
1
2

Compare providers for flights from Des Moines to Key West

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Key West in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Key West flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Key West flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Key West flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Key West flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Key West

How far ahead should I book a flight from Des Moines to Key West?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Key West. Price data was last updated on November 7, 2025.

The price you pay for your flight from Des Moines to Key West may vary depending on when you book. For the best chance of a lower fare, look to book 35 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Key West?

Currently, July is the cheapest month in which you can book a flight from Des Moines to Key West (average of $82). Flying from Des Moines to Key West in August is currently the most expensive (average of $324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated November 13, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Key West to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Overall

7.9

Crew

8.5

Food

7.3

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Overall

7.9

Crew

8.5

Food

7.3

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,017 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Overall

7.9

Crew

8.5

Food

7.3

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,051 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Overall

7.9

Crew

8.5

Food

7.3

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.2
Good
698 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Overall

7.9

Crew

8.5

Food

7.3

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Key West?

    Departing from Des Moines to Key West will take you 5h 43m. The distance between Des Moines and Key West is about 1357 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Des Moines to Key West round-trip?

    Allegiant Air, at $76, was found to be the cheapest airline from Des Moines to Key West.Alternate airlines to your destination round-trip include American Airlines and Delta. Users have found that Allegiant Air is 83% cheaper than the other options available to this destination.

  • Can I find deals for flights from Des Moines to Key West that include hotel bookings?

    Yes. In addition to deals on Des Moines to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Key West.

  • Can I find deals for business class flights from Des Moines to Key West?

    Yes. Cheapflights offers flight deals from Des Moines to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Key West?

    Currently, July is the cheapest month in which you can book a flight from Des Moines to Key West (average of $82). Flying from Des Moines to Key West in August is currently the most expensive (average of $324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Des Moines to Key West

Discover the top 4 airlines that operate flights from Des Moines to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$157FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$268Average$517FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$475FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$281Average$502FlexibilityNo cancel feeOn-time69%

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