$266+ Cheap flights from Des Moines to Key West (DSM - EYW)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/4. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Jul 6 — Jul 131
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Key West with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Key West
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Best
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Cheapest flights from Des Moines to Key WestExplore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 6, 2026.
Explore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
- EYW
1 stop18h 04m
Multiple Airlines
Sat 7/112:44 pm
EYW
- DSM
1 stop7h 59m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/44:59 pm
DSM
- EYW
1 stop18h 49m
Allegiant Air
Sat 7/112:44 pm
EYW
- DSM
1 stop7h 59m
Allegiant Air
Deal found 6/4![Allegiant Air logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
- EYW
1 stop18h 04m
Multiple Airlines
Fri 7/104:41 pm
EYW
- DSM
1 stop6h 34m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/44:59 pm
DSM
- EYW
1 stop18h 49m
Allegiant Air
Fri 7/104:41 pm
EYW
- DSM
1 stop6h 34m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:30 pm
DSM
- EYW
2 stops42h 18m
Allegiant Air
Fri 7/104:41 pm
EYW
- DSM
1 stop6h 34m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$282
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:30 am
DSM
- EYW
1 stop7h 21m
Delta
Tue 7/217:50 am
EYW
- DSM
1 stop6h 44m
Delta
Deal found 6/3![Delta logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
- EYW
1 stop18h 04m
Multiple Airlines
Mon 7/131:11 pm
EYW
- DSM
1 stop10h 04m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:30 pm
DSM
- EYW
2 stops40h 55m
Multiple Airlines
Sat 7/112:44 pm
EYW
- DSM
1 stop7h 59m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
- EYW
1 stop18h 04m
Multiple Airlines
Wed 7/85:10 pm
EYW
- DSM
2 stops17h 57m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/13:20 pm
DSM
- EYW
1 stop26h 53m
Multiple Airlines
Thu 8/69:31 pm
EYW
- DSM
2 stops26h 43m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$301
Best flights from Des Moines to Key WestDiscover carefully curated flight deals from Des Moines to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 6, 2026.
Discover carefully curated flight deals from Des Moines to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 6, 2026.
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:30 am
DSM
- EYW
1 stop7h 21m
Delta
Tue 7/217:50 am
EYW
- DSM
1 stop6h 44m
Delta
Deal found 6/3![Delta logo]()
$289
This American Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/39:02 am
DSM
- EYW
1 stop5h 48m
American Airlines
Mon 7/67:33 pm
EYW
- DSM
1 stop5h 36m
American Airlines
Deal found 6/5![American Airlines logo]()
$426
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/311:42 am
DSM
- EYW
1 stop7h 11m
Delta
Thu 7/96:18 pm
EYW
- DSM
1 stop5h 11m
Delta
Deal found 6/1![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/411:40 am
DSM
- EYW
1 stop7h 13m
Delta
Thu 7/96:18 pm
EYW
- DSM
1 stop5h 11m
Delta
Deal found 6/1![Delta logo]()
$381
This American Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:04 am
DSM
- EYW
2 stops11h 25m
American Airlines
Sat 11/712:40 pm
EYW
- DSM
2 stops10h 29m
American Airlines
Deal found 6/4![American Airlines logo]()
$465
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/711:30 am
DSM
- EYW
1 stop4h 53m
Delta
Fri 7/106:18 pm
EYW
- DSM
1 stop17h 27m
Delta
Deal found 6/1![Delta logo]()
$508
This American Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am
DSM
- EYW
1 stop6h 42m
American Airlines
Mon 10/123:40 pm
EYW
- DSM
1 stop8h 27m
American Airlines
Deal found 6/4![American Airlines logo]()
$559
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/711:30 am
DSM
- EYW
1 stop7h 21m
Delta
Thu 7/911:56 am
EYW
- DSM
1 stop6h 56m
Delta
Deal found 6/1![Delta logo]()
$647
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/65:35 am
DSM
- EYW
1 stop6h 53m
Delta
Fri 7/106:18 pm
EYW
- DSM
1 stop5h 11m
Delta
Deal found 6/3![Delta logo]()
$647
Last-minute flights from Des Moines to Key WestDiscover last-minute flight deals from Des Moines to Key West. Data last updated June 6, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Key West. Data last updated June 6, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:30 pm
DSM
- EYW
2 stops42h 18m
Allegiant Air
Fri 7/104:41 pm
EYW
- DSM
1 stop6h 34m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:30 pm
DSM
- EYW
2 stops40h 55m
Multiple Airlines
Sat 7/112:44 pm
EYW
- DSM
1 stop7h 59m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
- EYW
1 stop18h 04m
Multiple Airlines
Sat 7/112:44 pm
EYW
- DSM
1 stop7h 59m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/44:59 pm
DSM
- EYW
1 stop18h 49m
Allegiant Air
Sat 7/112:44 pm
EYW
- DSM
1 stop7h 59m
Allegiant Air
Deal found 6/4![Allegiant Air logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
- EYW
1 stop18h 04m
Multiple Airlines
Fri 7/104:41 pm
EYW
- DSM
1 stop6h 34m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/44:59 pm
DSM
- EYW
1 stop18h 49m
Allegiant Air
Fri 7/104:41 pm
EYW
- DSM
1 stop6h 34m
Allegiant Air
Deal found 6/5![Allegiant Air logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
- EYW
1 stop18h 04m
Multiple Airlines
Mon 7/131:11 pm
EYW
- DSM
1 stop10h 04m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
- EYW
1 stop18h 04m
Multiple Airlines
Wed 7/85:10 pm
EYW
- DSM
2 stops17h 57m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:20 pm
DSM
- EYW
1 stop18h 04m
Multiple Airlines
Thu 7/98:48 pm
EYW
- DSM
2 stops20h 52m
Multiple Airlines
Deal found 6/1![Multiple Airlines logo]()
$302
This Delta deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1411:30 am
DSM
- EYW
1 stop7h 21m
Delta
Tue 7/217:50 am
EYW
- DSM
1 stop6h 44m
Delta
Deal found 6/3![Delta logo]()
$289
One-way flights from Des Moines to Key WestSearch for one-way flight options from Des Moines to Key West. Find affordable one-way fares based on user searches. Data last updated June 6, 2026.
Search for one-way flight options from Des Moines to Key West. Find affordable one-way fares based on user searches. Data last updated June 6, 2026.
This Delta deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/155:44 am
DSM
- EYW
1 stop6h 14m
Delta
Deal found 6/1![Delta logo]()
$324
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:00 am
DSM
- EYW
2 stops10h 55m
American Airlines
Deal found 6/1![American Airlines logo]()
$358
Find flight deals from Des Moines to Key West
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $266 (Kiwi.com) |
Popular in | February |
Cheapest in | July |
Average price | $557 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 6, 2026.
Use the filters below to find and compare flights from Des Moines to Key West that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Tue 7/14
11:30 am-7:51 pm
1 stop7h 21m
Key West
Tue 7/21
7:50 am-1:34 pm
1 stop6h 44m
$289
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Fri 7/3
11:42 am-7:53 pm
1 stop7h 11m
Key West
Thu 7/9
6:18 pm-10:29 pm
1 stop5h 11m
$329
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 7/4
11:40 am-7:53 pm
1 stop7h 13m
Key West
Thu 7/9
6:18 pm-10:29 pm
1 stop5h 11m
$381
Quickest round-trip
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Fri 7/3
9:02 am-3:50 pm
1 stop5h 48m
Key West
Mon 7/6
7:33 pm-12:09 am
1 stop5h 36m
$426
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Wed 11/4
7:04 am-7:29 pm
2 stops11h 25m
Key West
Sat 11/7
12:40 pm-10:09 pm
2 stops10h 29m
$465
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Tue 7/7
11:30 am-5:23 pm
1 stop4h 53m
Key West
Fri 7/10
6:18 pm-10:45 am
1 stop17h 27m
$508
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Wed 10/7
6:00 am-1:42 pm
1 stop6h 42m
Key West
Mon 10/12
3:40 pm-11:07 pm
1 stop8h 27m
$559
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Tue 7/7
11:30 am-7:51 pm
1 stop7h 21m
Key West
Thu 7/9
11:56 am-5:52 pm
1 stop6h 56m
$647
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Mon 7/6
5:35 am-1:28 pm
1 stop6h 53m
Key West
Fri 7/10
6:18 pm-10:29 pm
1 stop5h 11m
$647
Cheapest one-way
Quickest one-way
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Tue 9/15
5:44 am-12:58 pm
1 stop6h 14m
$324
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Key West
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Key West in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Key West flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Key West flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Des Moines with our price prediction graph.
DSM-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Key West
What is the cheapest month to book a flight from Des Moines to Key West?
Currently, July is the cheapest month in which you can book a flight from Des Moines to Key West (average of $289). Flying from Des Moines to Key West in February is currently the most expensive (average of $609). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Key West?
Reviews of airlines servicing Key West
Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated June 6, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAllegiant Air from Des Moines to Key West to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
7.9
Food
7.2
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.9
Food
7.2
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.9
Food
7.2
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.9
Food
7.2
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.9
Food
7.2
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Other flights to Key West
Explore flights to Key West departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 6, 2026.
Des Moines and Key West flights
Browse other Des Moines and Key West flight options. Last updated on June 6, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on June 6, 2026.
Popular flight searches
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Top 4 airlines flying from Des Moines to Key West
Discover the top 4 airlines that operate flights from Des Moines to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$76 | Average$102 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$268 | Average$483 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$268 | Average$434 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$288 | Average$447 | FlexibilityNo cancel fee | On-time69% |